                         SEQUENCE LISTING

<110>  The Broad Institute, Inc.
       President and Fellows of Harvard College
 
<120>  AAV DELIVERY OF NUCLEOBASE EDITORS

<130>  B1195.70080WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/850,523
<151>  2019-05-20

<150>  US 62/949,275
<151>  2019-12-17

<160>  743   

<170>  PatentIn version 3.5

<210>  1
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  1

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  2
<211>  1360
<212>  PRT
<213>  S. pyogenes

<400>  2

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  
    1355                 1360 


<210>  3
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  3

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  4
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  4

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Val  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Arg 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Glu  Tyr Arg Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  5
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  5

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Val  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Gln  Tyr Arg Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  6
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  6

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Glu  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Gln  Tyr Arg Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  7
<211>  1053
<212>  PRT
<213>  S. aureus

<400>  7

Met Lys Arg Asn Tyr Ile Leu Gly Leu Ala Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Lys Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro His  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210>  8
<211>  1121
<212>  PRT
<213>  Streptococcus thermophilus

<400>  8

Met Ser Asp Leu Val Leu Gly Leu Ala Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Ile Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Ala Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Gln Ile Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln 
945                 950                 955                 960 


Ser Val Ser Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr Gly 
                965                 970                 975     


Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Thr Tyr Lys Ile Ser  Gln Glu Lys Tyr Asn  Asp Ile Lys 
        995                 1000                 1005             


Lys Lys  Glu Gly Val Asp Ser  Asp Ser Glu Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Asn Asp Leu Leu Leu  Val Lys Asp Thr Glu  Thr Lys Glu 
    1025                 1030                 1035             


Gln Gln  Leu Phe Arg Phe Leu  Ser Arg Thr Met Pro  Lys Gln Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Asp Lys Gln Lys  Phe Glu Gly 
    1055                 1060                 1065             


Gly Glu  Ala Leu Ile Lys Val  Leu Gly Asn Val Ala  Asn Ser Gly 
    1070                 1075                 1080             


Gln Cys  Lys Lys Gly Leu Gly  Lys Ser Asn Ile Ser  Ile Tyr Lys 
    1085                 1090                 1095             


Val Arg  Thr Asp Val Leu Gly  Asn Gln His Ile Ile  Lys Asn Glu 
    1100                 1105                 1110             


Gly Asp  Lys Pro Lys Leu Asp  Phe 
    1115                 1120     


<210>  9
<211>  1388
<212>  PRT
<213>  Streptococcus thermophilus

<400>  9

Met Thr Lys Pro Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asn Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Val Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Cys Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Asn Leu Leu Ala Glu Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Glu Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp Glu Asp Lys Gly Asn 
705                 710                 715                 720 


Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg 
    770                 775                 780                 


Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 
785                 790                 795                 800 


Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Phe Pro Ser Leu 
865                 870                 875                 880 


Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gln Leu Leu Lys Ser 
                885                 890                 895     


Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Leu Pro Glu Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 
    930                 935                 940                 


Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg Ala Val Arg Thr Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Phe His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Ile  Ala Ser Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Phe Arg Glu Arg Lys  Ser Ala Thr Glu Lys  Val Tyr Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Ile  Phe Lys Lys Ser Ile  Ser Leu Ala 
    1040                 1045                 1050             


Asp Gly  Arg Val Ile Glu Arg  Pro Leu Ile Glu Val  Asn Glu Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ser Val Trp Asn  Lys Glu Ser Asp Leu  Ala Thr Val 
    1070                 1075                 1080             


Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Glu  Gln Asn His Gly Leu  Asp Arg Gly Lys Pro  Lys Gly Leu 
    1100                 1105                 1110             


Phe Asn  Ala Asn Leu Ser Ser  Lys Pro Lys Pro Asn  Ser Asn Glu 
    1115                 1120                 1125             


Asn Leu  Val Gly Ala Lys Glu  Tyr Leu Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Gly Ile Ser Asn  Ser Phe Ala Val Leu  Val Lys Gly 
    1145                 1150                 1155             


Thr Ile  Glu Lys Gly Ala Lys  Lys Lys Ile Thr Asn  Val Leu Glu 
    1160                 1165                 1170             


Phe Gln  Gly Ile Ser Ile Leu  Asp Arg Ile Asn Tyr  Arg Lys Asp 
    1175                 1180                 1185             


Lys Leu  Asn Phe Leu Leu Glu  Lys Gly Tyr Lys Asp  Ile Glu Leu 
    1190                 1195                 1200             


Ile Ile  Glu Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Ser Asp Gly 
    1205                 1210                 1215             


Ser Arg  Arg Met Leu Ala Ser  Ile Leu Ser Thr Asn  Asn Lys Arg 
    1220                 1225                 1230             


Gly Glu  Ile His Lys Gly Asn  Gln Ile Phe Leu Ser  Gln Lys Phe 
    1235                 1240                 1245             


Val Lys  Leu Leu Tyr His Ala  Lys Arg Ile Ser Asn  Thr Ile Asn 
    1250                 1255                 1260             


Glu Asn  His Arg Lys Tyr Val  Glu Asn His Lys Lys  Glu Phe Glu 
    1265                 1270                 1275             


Glu Leu  Phe Tyr Tyr Ile Leu  Glu Phe Asn Glu Asn  Tyr Val Gly 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Lys Leu  Leu Asn Ser Ala Phe  Gln Ser Trp 
    1295                 1300                 1305             


Gln Asn  His Ser Ile Asp Glu  Leu Cys Ser Ser Phe  Ile Gly Pro 
    1310                 1315                 1320             


Thr Gly  Ser Glu Arg Lys Gly  Leu Phe Glu Leu Thr  Ser Arg Gly 
    1325                 1330                 1335             


Ser Ala  Ala Asp Phe Glu Phe  Leu Gly Val Lys Ile  Pro Arg Tyr 
    1340                 1345                 1350             


Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Lys Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ala 
    1370                 1375                 1380             


Lys Leu  Gly Glu Gly 
    1385             


<210>  10
<211>  1053
<212>  PRT
<213>  S. aureus

<400>  10

Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210>  11
<211>  1054
<212>  PRT
<213>  S. aureus

<400>  11

Met Lys Arg Asn Tyr Ile Leu Gly Leu Ala Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Ile Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu 
    690                 695                 700                 


Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys 
705                 710                 715                 720 


Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu 
                725                 730                 735     


Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys 
            740                 745                 750         


Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys 
        755                 760                 765             


Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu 
    770                 775                 780                 


Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr 
785                 790                 795                 800 


Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys 
                805                 810                 815     


Leu Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His 
            820                 825                 830         


His Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr 
        835                 840                 845             


Gly Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn 
    850                 855                 860                 


Tyr Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys 
865                 870                 875                 880 


Ile Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp 
                885                 890                 895     


Asp Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro 
            900                 905                 910         


Tyr Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr 
        915                 920                 925             


Val Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn 
    930                 935                 940                 


Ser Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln 
945                 950                 955                 960 


Ala Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn 
                965                 970                 975     


Gly Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg 
            980                 985                 990         


Ile Glu Val Asn Met Ile Asp Ile  Thr Tyr Arg Glu Tyr  Leu Glu Asn 
        995                 1000                 1005             


Met Asn  Asp Lys Arg Pro Pro  Arg Ile Ile Lys Thr  Ile Ala Ser 
    1010                 1015                 1020             


Lys Thr  Gln Ser Ile Lys Lys  Tyr Ser Thr Asp Ile  Leu Gly Asn 
    1025                 1030                 1035             


Leu Tyr  Glu Val Lys Ser Lys  Lys His Pro Gln Ile  Ile Lys Lys 
    1040                 1045                 1050             


Gly 
    


<210>  12
<211>  1388
<212>  PRT
<213>  Streptococcus thermophilus

<400>  12

Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asn Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Val Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Cys Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Asn Leu Leu Ala Glu Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Glu Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp Glu Asp Lys Gly Asn 
705                 710                 715                 720 


Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg 
    770                 775                 780                 


Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 
785                 790                 795                 800 


Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Phe Pro Ser Leu 
865                 870                 875                 880 


Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gln Leu Leu Lys Ser 
                885                 890                 895     


Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Leu Pro Glu Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 
    930                 935                 940                 


Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg Ala Val Arg Thr Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Phe His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Ile  Ala Ser Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Phe Arg Glu Arg Lys  Ser Ala Thr Glu Lys  Val Tyr Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Ile  Phe Lys Lys Ser Ile  Ser Leu Ala 
    1040                 1045                 1050             


Asp Gly  Arg Val Ile Glu Arg  Pro Leu Ile Glu Val  Asn Glu Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ser Val Trp Asn  Lys Glu Ser Asp Leu  Ala Thr Val 
    1070                 1075                 1080             


Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Glu  Gln Asn His Gly Leu  Asp Arg Gly Lys Pro  Lys Gly Leu 
    1100                 1105                 1110             


Phe Asn  Ala Asn Leu Ser Ser  Lys Pro Lys Pro Asn  Ser Asn Glu 
    1115                 1120                 1125             


Asn Leu  Val Gly Ala Lys Glu  Tyr Leu Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Gly Ile Ser Asn  Ser Phe Ala Val Leu  Val Lys Gly 
    1145                 1150                 1155             


Thr Ile  Glu Lys Gly Ala Lys  Lys Lys Ile Thr Asn  Val Leu Glu 
    1160                 1165                 1170             


Phe Gln  Gly Ile Ser Ile Leu  Asp Arg Ile Asn Tyr  Arg Lys Asp 
    1175                 1180                 1185             


Lys Leu  Asn Phe Leu Leu Glu  Lys Gly Tyr Lys Asp  Ile Glu Leu 
    1190                 1195                 1200             


Ile Ile  Glu Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Ser Asp Gly 
    1205                 1210                 1215             


Ser Arg  Arg Met Leu Ala Ser  Ile Leu Ser Thr Asn  Asn Lys Arg 
    1220                 1225                 1230             


Gly Glu  Ile His Lys Gly Asn  Gln Ile Phe Leu Ser  Gln Lys Phe 
    1235                 1240                 1245             


Val Lys  Leu Leu Tyr His Ala  Lys Arg Ile Ser Asn  Thr Ile Asn 
    1250                 1255                 1260             


Glu Asn  His Arg Lys Tyr Val  Glu Asn His Lys Lys  Glu Phe Glu 
    1265                 1270                 1275             


Glu Leu  Phe Tyr Tyr Ile Leu  Glu Phe Asn Glu Asn  Tyr Val Gly 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Lys Leu  Leu Asn Ser Ala Phe  Gln Ser Trp 
    1295                 1300                 1305             


Gln Asn  His Ser Ile Asp Glu  Leu Cys Ser Ser Phe  Ile Gly Pro 
    1310                 1315                 1320             


Thr Gly  Ser Glu Arg Lys Gly  Leu Phe Glu Leu Thr  Ser Arg Gly 
    1325                 1330                 1335             


Ser Ala  Ala Asp Phe Glu Phe  Leu Gly Val Lys Ile  Pro Arg Tyr 
    1340                 1345                 1350             


Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Lys Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ala 
    1370                 1375                 1380             


Lys Leu  Gly Glu Gly 
    1385             


<210>  13
<211>  1121
<212>  PRT
<213>  Streptococcus thermophilus

<400>  13

Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Ile Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Ala Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Gln Ile Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln 
945                 950                 955                 960 


Ser Val Ser Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr Gly 
                965                 970                 975     


Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Thr Tyr Lys Ile Ser  Gln Glu Lys Tyr Asn  Asp Ile Lys 
        995                 1000                 1005             


Lys Lys  Glu Gly Val Asp Ser  Asp Ser Glu Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Asn Asp Leu Leu Leu  Val Lys Asp Thr Glu  Thr Lys Glu 
    1025                 1030                 1035             


Gln Gln  Leu Phe Arg Phe Leu  Ser Arg Thr Met Pro  Lys Gln Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Asp Lys Gln Lys  Phe Glu Gly 
    1055                 1060                 1065             


Gly Glu  Ala Leu Ile Lys Val  Leu Gly Asn Val Ala  Asn Ser Gly 
    1070                 1075                 1080             


Gln Cys  Lys Lys Gly Leu Gly  Lys Ser Asn Ile Ser  Ile Tyr Lys 
    1085                 1090                 1095             


Val Arg  Thr Asp Val Leu Gly  Asn Gln His Ile Ile  Lys Asn Glu 
    1100                 1105                 1110             


Gly Asp  Lys Pro Lys Leu Asp  Phe 
    1115                 1120     


<210>  14
<211>  345
<212>  PRT
<213>  Sulfolobus islandicus

<400>  14

Met Glu Val Pro Leu Tyr Asn Ile Phe Gly Asp Asn Tyr Ile Ile Gln 
1               5                   10                  15      


Val Ala Thr Glu Ala Glu Asn Ser Thr Ile Tyr Asn Asn Lys Val Glu 
            20                  25                  30          


Ile Asp Asp Glu Glu Leu Arg Asn Val Leu Asn Leu Ala Tyr Lys Ile 
        35                  40                  45              


Ala Lys Asn Asn Glu Asp Ala Ala Ala Glu Arg Arg Gly Lys Ala Lys 
    50                  55                  60                  


Lys Lys Lys Gly Glu Glu Gly Glu Thr Thr Thr Ser Asn Ile Ile Leu 
65                  70                  75                  80  


Pro Leu Ser Gly Asn Asp Lys Asn Pro Trp Thr Glu Thr Leu Lys Cys 
                85                  90                  95      


Tyr Asn Phe Pro Thr Thr Val Ala Leu Ser Glu Val Phe Lys Asn Phe 
            100                 105                 110         


Ser Gln Val Lys Glu Cys Glu Glu Val Ser Ala Pro Ser Phe Val Lys 
        115                 120                 125             


Pro Glu Phe Tyr Lys Phe Gly Arg Ser Pro Gly Met Val Glu Arg Thr 
    130                 135                 140                 


Arg Arg Val Lys Leu Glu Val Glu Pro His Tyr Leu Ile Met Ala Ala 
145                 150                 155                 160 


Ala Gly Trp Val Leu Thr Arg Leu Gly Lys Ala Lys Val Ser Glu Gly 
                165                 170                 175     


Asp Tyr Val Gly Val Asn Val Phe Thr Pro Thr Arg Gly Ile Leu Tyr 
            180                 185                 190         


Ser Leu Ile Gln Asn Val Asn Gly Ile Val Pro Gly Ile Lys Pro Glu 
        195                 200                 205             


Thr Ala Phe Gly Leu Trp Ile Ala Arg Lys Val Val Ser Ser Val Thr 
    210                 215                 220                 


Asn Pro Asn Val Ser Val Val Ser Ile Tyr Thr Ile Ser Asp Ala Val 
225                 230                 235                 240 


Gly Gln Asn Pro Thr Thr Ile Asn Gly Gly Phe Ser Ile Asp Leu Thr 
                245                 250                 255     


Lys Leu Leu Glu Lys Arg Asp Leu Leu Ser Glu Arg Leu Glu Ala Ile 
            260                 265                 270         


Ala Arg Asn Ala Leu Ser Ile Ser Ser Asn Met Arg Glu Arg Tyr Ile 
        275                 280                 285             


Val Leu Ala Asn Tyr Ile Tyr Glu Tyr Leu Thr Gly Ser Lys Arg Leu 
    290                 295                 300                 


Glu Asp Leu Leu Tyr Phe Ala Asn Arg Asp Leu Ile Met Asn Leu Asn 
305                 310                 315                 320 


Ser Asp Asp Gly Lys Val Arg Asp Leu Lys Leu Ile Ser Ala Tyr Val 
                325                 330                 335     


Asn Gly Glu Leu Ile Arg Gly Glu Gly 
            340                 345 


<210>  15
<211>  345
<212>  PRT
<213>  Sulfolobus islandicus

<400>  15

Met Glu Val Pro Leu Tyr Asn Ile Phe Gly Asp Asn Tyr Ile Ile Gln 
1               5                   10                  15      


Val Ala Thr Glu Ala Glu Asn Ser Thr Ile Tyr Asn Asn Lys Val Glu 
            20                  25                  30          


Ile Asp Asp Glu Glu Leu Arg Asn Val Leu Asn Leu Ala Tyr Lys Ile 
        35                  40                  45              


Ala Lys Asn Asn Glu Asp Ala Ala Ala Glu Arg Arg Gly Lys Ala Lys 
    50                  55                  60                  


Lys Lys Lys Gly Glu Glu Gly Glu Thr Thr Thr Ser Asn Ile Ile Leu 
65                  70                  75                  80  


Pro Leu Ser Gly Asn Asp Lys Asn Pro Trp Thr Glu Thr Leu Lys Cys 
                85                  90                  95      


Tyr Asn Phe Pro Thr Thr Val Ala Leu Ser Glu Val Phe Lys Asn Phe 
            100                 105                 110         


Ser Gln Val Lys Glu Cys Glu Glu Val Ser Ala Pro Ser Phe Val Lys 
        115                 120                 125             


Pro Glu Phe Tyr Glu Phe Gly Arg Ser Pro Gly Met Val Glu Arg Thr 
    130                 135                 140                 


Arg Arg Val Lys Leu Glu Val Glu Pro His Tyr Leu Ile Ile Ala Ala 
145                 150                 155                 160 


Ala Gly Trp Val Leu Thr Arg Leu Gly Lys Ala Lys Val Ser Glu Gly 
                165                 170                 175     


Asp Tyr Val Gly Val Asn Val Phe Thr Pro Thr Arg Gly Ile Leu Tyr 
            180                 185                 190         


Ser Leu Ile Gln Asn Val Asn Gly Ile Val Pro Gly Ile Lys Pro Glu 
        195                 200                 205             


Thr Ala Phe Gly Leu Trp Ile Ala Arg Lys Val Val Ser Ser Val Thr 
    210                 215                 220                 


Asn Pro Asn Val Ser Val Val Arg Ile Tyr Thr Ile Ser Asp Ala Val 
225                 230                 235                 240 


Gly Gln Asn Pro Thr Thr Ile Asn Gly Gly Phe Ser Ile Asp Leu Thr 
                245                 250                 255     


Lys Leu Leu Glu Lys Arg Tyr Leu Leu Ser Glu Arg Leu Glu Ala Ile 
            260                 265                 270         


Ala Arg Asn Ala Leu Ser Ile Ser Ser Asn Met Arg Glu Arg Tyr Ile 
        275                 280                 285             


Val Leu Ala Asn Tyr Ile Tyr Glu Tyr Leu Thr Gly Ser Lys Arg Leu 
    290                 295                 300                 


Glu Asp Leu Leu Tyr Phe Ala Asn Arg Asp Leu Ile Met Asn Leu Asn 
305                 310                 315                 320 


Ser Asp Asp Gly Lys Val Arg Asp Leu Lys Leu Ile Ser Ala Tyr Val 
                325                 330                 335     


Asn Gly Glu Leu Ile Arg Gly Glu Gly 
            340                 345 


<210>  16
<211>  1300
<212>  PRT
<213>  Francisella novicida

<400>  16

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  17
<211>  1300
<212>  PRT
<213>  Francisella novicida

<400>  17

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Ala Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  18
<211>  1300
<212>  PRT
<213>  Francisella novicida

<400>  18

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Ala Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  19
<211>  1300
<212>  PRT
<213>  Francisella novicida

<400>  19

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Ala  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  20
<211>  1300
<212>  PRT
<213>  Francisella novicida

<400>  20

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Ala Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Ala Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  21
<211>  1300
<212>  PRT
<213>  Francisella novicida

<400>  21

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Ala Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Ala  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  22
<211>  1300
<212>  PRT
<213>  Francisella novicida

<400>  22

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Ala Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Ala  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  23
<211>  1300
<212>  PRT
<213>  Francisella novicida

<400>  23

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Ala Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Ala Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Ala  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  24
<211>  887
<212>  PRT
<213>  Natronobacterium gregoryi

<400>  24

Met Thr Val Ile Asp Leu Asp Ser Thr Thr Thr Ala Asp Glu Leu Thr 
1               5                   10                  15      


Ser Gly His Thr Tyr Asp Ile Ser Val Thr Leu Thr Gly Val Tyr Asp 
            20                  25                  30          


Asn Thr Asp Glu Gln His Pro Arg Met Ser Leu Ala Phe Glu Gln Asp 
        35                  40                  45              


Asn Gly Glu Arg Arg Tyr Ile Thr Leu Trp Lys Asn Thr Thr Pro Lys 
    50                  55                  60                  


Asp Val Phe Thr Tyr Asp Tyr Ala Thr Gly Ser Thr Tyr Ile Phe Thr 
65                  70                  75                  80  


Asn Ile Asp Tyr Glu Val Lys Asp Gly Tyr Glu Asn Leu Thr Ala Thr 
                85                  90                  95      


Tyr Gln Thr Thr Val Glu Asn Ala Thr Ala Gln Glu Val Gly Thr Thr 
            100                 105                 110         


Asp Glu Asp Glu Thr Phe Ala Gly Gly Glu Pro Leu Asp His His Leu 
        115                 120                 125             


Asp Asp Ala Leu Asn Glu Thr Pro Asp Asp Ala Glu Thr Glu Ser Asp 
    130                 135                 140                 


Ser Gly His Val Met Thr Ser Phe Ala Ser Arg Asp Gln Leu Pro Glu 
145                 150                 155                 160 


Trp Thr Leu His Thr Tyr Thr Leu Thr Ala Thr Asp Gly Ala Lys Thr 
                165                 170                 175     


Asp Thr Glu Tyr Ala Arg Arg Thr Leu Ala Tyr Thr Val Arg Gln Glu 
            180                 185                 190         


Leu Tyr Thr Asp His Asp Ala Ala Pro Val Ala Thr Asp Gly Leu Met 
        195                 200                 205             


Leu Leu Thr Pro Glu Pro Leu Gly Glu Thr Pro Leu Asp Leu Asp Cys 
    210                 215                 220                 


Gly Val Arg Val Glu Ala Asp Glu Thr Arg Thr Leu Asp Tyr Thr Thr 
225                 230                 235                 240 


Ala Lys Asp Arg Leu Leu Ala Arg Glu Leu Val Glu Glu Gly Leu Lys 
                245                 250                 255     


Arg Ser Leu Trp Asp Asp Tyr Leu Val Arg Gly Ile Asp Glu Val Leu 
            260                 265                 270         


Ser Lys Glu Pro Val Leu Thr Cys Asp Glu Phe Asp Leu His Glu Arg 
        275                 280                 285             


Tyr Asp Leu Ser Val Glu Val Gly His Ser Gly Arg Ala Tyr Leu His 
    290                 295                 300                 


Ile Asn Phe Arg His Arg Phe Val Pro Lys Leu Thr Leu Ala Asp Ile 
305                 310                 315                 320 


Asp Asp Asp Asn Ile Tyr Pro Gly Leu Arg Val Lys Thr Thr Tyr Arg 
                325                 330                 335     


Pro Arg Arg Gly His Ile Val Trp Gly Leu Arg Asp Glu Cys Ala Thr 
            340                 345                 350         


Asp Ser Leu Asn Thr Leu Gly Asn Gln Ser Val Val Ala Tyr His Arg 
        355                 360                 365             


Asn Asn Gln Thr Pro Ile Asn Thr Asp Leu Leu Asp Ala Ile Glu Ala 
    370                 375                 380                 


Ala Asp Arg Arg Val Val Glu Thr Arg Arg Gln Gly His Gly Asp Asp 
385                 390                 395                 400 


Ala Val Ser Phe Pro Gln Glu Leu Leu Ala Val Glu Pro Asn Thr His 
                405                 410                 415     


Gln Ile Lys Gln Phe Ala Ser Asp Gly Phe His Gln Gln Ala Arg Ser 
            420                 425                 430         


Lys Thr Arg Leu Ser Ala Ser Arg Cys Ser Glu Lys Ala Gln Ala Phe 
        435                 440                 445             


Ala Glu Arg Leu Asp Pro Val Arg Leu Asn Gly Ser Thr Val Glu Phe 
    450                 455                 460                 


Ser Ser Glu Phe Phe Thr Gly Asn Asn Glu Gln Gln Leu Arg Leu Leu 
465                 470                 475                 480 


Tyr Glu Asn Gly Glu Ser Val Leu Thr Phe Arg Asp Gly Ala Arg Gly 
                485                 490                 495     


Ala His Pro Asp Glu Thr Phe Ser Lys Gly Ile Val Asn Pro Pro Glu 
            500                 505                 510         


Ser Phe Glu Val Ala Val Val Leu Pro Glu Gln Gln Ala Asp Thr Cys 
        515                 520                 525             


Lys Ala Gln Trp Asp Thr Met Ala Asp Leu Leu Asn Gln Ala Gly Ala 
    530                 535                 540                 


Pro Pro Thr Arg Ser Glu Thr Val Gln Tyr Asp Ala Phe Ser Ser Pro 
545                 550                 555                 560 


Glu Ser Ile Ser Leu Asn Val Ala Gly Ala Ile Asp Pro Ser Glu Val 
                565                 570                 575     


Asp Ala Ala Phe Val Val Leu Pro Pro Asp Gln Glu Gly Phe Ala Asp 
            580                 585                 590         


Leu Ala Ser Pro Thr Glu Thr Tyr Asp Glu Leu Lys Lys Ala Leu Ala 
        595                 600                 605             


Asn Met Gly Ile Tyr Ser Gln Met Ala Tyr Phe Asp Arg Phe Arg Asp 
    610                 615                 620                 


Ala Lys Ile Phe Tyr Thr Arg Asn Val Ala Leu Gly Leu Leu Ala Ala 
625                 630                 635                 640 


Ala Gly Gly Val Ala Phe Thr Thr Glu His Ala Met Pro Gly Asp Ala 
                645                 650                 655     


Asp Met Phe Ile Gly Ile Asp Val Ser Arg Ser Tyr Pro Glu Asp Gly 
            660                 665                 670         


Ala Ser Gly Gln Ile Asn Ile Ala Ala Thr Ala Thr Ala Val Tyr Lys 
        675                 680                 685             


Asp Gly Thr Ile Leu Gly His Ser Ser Thr Arg Pro Gln Leu Gly Glu 
    690                 695                 700                 


Lys Leu Gln Ser Thr Asp Val Arg Asp Ile Met Lys Asn Ala Ile Leu 
705                 710                 715                 720 


Gly Tyr Gln Gln Val Thr Gly Glu Ser Pro Thr His Ile Val Ile His 
                725                 730                 735     


Arg Asp Gly Phe Met Asn Glu Asp Leu Asp Pro Ala Thr Glu Phe Leu 
            740                 745                 750         


Asn Glu Gln Gly Val Glu Tyr Asp Ile Val Glu Ile Arg Lys Gln Pro 
        755                 760                 765             


Gln Thr Arg Leu Leu Ala Val Ser Asp Val Gln Tyr Asp Thr Pro Val 
    770                 775                 780                 


Lys Ser Ile Ala Ala Ile Asn Gln Asn Glu Pro Arg Ala Thr Val Ala 
785                 790                 795                 800 


Thr Phe Gly Ala Pro Glu Tyr Leu Ala Thr Arg Asp Gly Gly Gly Leu 
                805                 810                 815     


Pro Arg Pro Ile Gln Ile Glu Arg Val Ala Gly Glu Thr Asp Ile Glu 
            820                 825                 830         


Thr Leu Thr Arg Gln Val Tyr Leu Leu Ser Gln Ser His Ile Gln Val 
        835                 840                 845             


His Asn Ser Thr Ala Arg Leu Pro Ile Thr Thr Ala Tyr Ala Asp Gln 
    850                 855                 860                 


Ala Ser Thr His Ala Thr Lys Gly Tyr Leu Val Gln Thr Gly Ala Phe 
865                 870                 875                 880 


Glu Ser Asn Val Gly Phe Leu 
                885         


<210>  25
<211>  1367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Ala 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Ala Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Ala Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Ala Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  26
<211>  1210
<212>  PRT
<213>  Unknown

<220>
<223>  Uncultured Parcubacteria Group Bacterium

<400>  26

Met Ser Lys Arg His Pro Arg Ile Ser Gly Val Lys Gly Tyr Arg Leu 
1               5                   10                  15      


His Ala Gln Arg Leu Glu Tyr Thr Gly Lys Ser Gly Ala Met Arg Thr 
            20                  25                  30          


Ile Lys Tyr Pro Leu Tyr Ser Ser Pro Ser Gly Gly Arg Thr Val Pro 
        35                  40                  45              


Arg Glu Ile Val Ser Ala Ile Asn Asp Asp Tyr Val Gly Leu Tyr Gly 
    50                  55                  60                  


Leu Ser Asn Phe Asp Asp Leu Tyr Asn Ala Glu Lys Arg Asn Glu Glu 
65                  70                  75                  80  


Lys Val Tyr Ser Val Leu Asp Phe Trp Tyr Asp Cys Val Gln Tyr Gly 
                85                  90                  95      


Ala Val Phe Ser Tyr Thr Ala Pro Gly Leu Leu Lys Asn Val Ala Glu 
            100                 105                 110         


Val Arg Gly Gly Ser Tyr Glu Leu Thr Lys Thr Leu Lys Gly Ser His 
        115                 120                 125             


Leu Tyr Asp Glu Leu Gln Ile Asp Lys Val Ile Lys Phe Leu Asn Lys 
    130                 135                 140                 


Lys Glu Ile Ser Arg Ala Asn Gly Ser Leu Asp Lys Leu Lys Lys Asp 
145                 150                 155                 160 


Ile Ile Asp Cys Phe Lys Ala Glu Tyr Arg Glu Arg His Lys Asp Gln 
                165                 170                 175     


Cys Asn Lys Leu Ala Asp Asp Ile Lys Asn Ala Lys Lys Asp Ala Gly 
            180                 185                 190         


Ala Ser Leu Gly Glu Arg Gln Lys Lys Leu Phe Arg Asp Phe Phe Gly 
        195                 200                 205             


Ile Ser Glu Gln Ser Glu Asn Asp Lys Pro Ser Phe Thr Asn Pro Leu 
    210                 215                 220                 


Asn Leu Thr Cys Cys Leu Leu Pro Phe Asp Thr Val Asn Asn Asn Arg 
225                 230                 235                 240 


Asn Arg Gly Glu Val Leu Phe Asn Lys Leu Lys Glu Tyr Ala Gln Lys 
                245                 250                 255     


Leu Asp Lys Asn Glu Gly Ser Leu Glu Met Trp Glu Tyr Ile Gly Ile 
            260                 265                 270         


Gly Asn Ser Gly Thr Ala Phe Ser Asn Phe Leu Gly Glu Gly Phe Leu 
        275                 280                 285             


Gly Arg Leu Arg Glu Asn Lys Ile Thr Glu Leu Lys Lys Ala Met Met 
    290                 295                 300                 


Asp Ile Thr Asp Ala Trp Arg Gly Gln Glu Gln Glu Glu Glu Leu Glu 
305                 310                 315                 320 


Lys Arg Leu Arg Ile Leu Ala Ala Leu Thr Ile Lys Leu Arg Glu Pro 
                325                 330                 335     


Lys Phe Asp Asn His Trp Gly Gly Tyr Arg Ser Asp Ile Asn Gly Lys 
            340                 345                 350         


Leu Ser Ser Trp Leu Gln Asn Tyr Ile Asn Gln Thr Val Lys Ile Lys 
        355                 360                 365             


Glu Asp Leu Lys Gly His Lys Lys Asp Leu Lys Lys Ala Lys Glu Met 
    370                 375                 380                 


Ile Asn Arg Phe Gly Glu Ser Asp Thr Lys Glu Glu Ala Val Val Ser 
385                 390                 395                 400 


Ser Leu Leu Glu Ser Ile Glu Lys Ile Val Pro Asp Asp Ser Ala Asp 
                405                 410                 415     


Asp Glu Lys Pro Asp Ile Pro Ala Ile Ala Ile Tyr Arg Arg Phe Leu 
            420                 425                 430         


Ser Asp Gly Arg Leu Thr Leu Asn Arg Phe Val Gln Arg Glu Asp Val 
        435                 440                 445             


Gln Glu Ala Leu Ile Lys Glu Arg Leu Glu Ala Glu Lys Lys Lys Lys 
    450                 455                 460                 


Pro Lys Lys Arg Lys Lys Lys Ser Asp Ala Glu Asp Glu Lys Glu Thr 
465                 470                 475                 480 


Ile Asp Phe Lys Glu Leu Phe Pro His Leu Ala Lys Pro Leu Lys Leu 
                485                 490                 495     


Val Pro Asn Phe Tyr Gly Asp Ser Lys Arg Glu Leu Tyr Lys Lys Tyr 
            500                 505                 510         


Lys Asn Ala Ala Ile Tyr Thr Asp Ala Leu Trp Lys Ala Val Glu Lys 
        515                 520                 525             


Ile Tyr Lys Ser Ala Phe Ser Ser Ser Leu Lys Asn Ser Phe Phe Asp 
    530                 535                 540                 


Thr Asp Phe Asp Lys Asp Phe Phe Ile Lys Arg Leu Gln Lys Ile Phe 
545                 550                 555                 560 


Ser Val Tyr Arg Arg Phe Asn Thr Asp Lys Trp Lys Pro Ile Val Lys 
                565                 570                 575     


Asn Ser Phe Ala Pro Tyr Cys Asp Ile Val Ser Leu Ala Glu Asn Glu 
            580                 585                 590         


Val Leu Tyr Lys Pro Lys Gln Ser Arg Ser Arg Lys Ser Ala Ala Ile 
        595                 600                 605             


Asp Lys Asn Arg Val Arg Leu Pro Ser Thr Glu Asn Ile Ala Lys Ala 
    610                 615                 620                 


Gly Ile Ala Leu Ala Arg Glu Leu Ser Val Ala Gly Phe Asp Trp Lys 
625                 630                 635                 640 


Asp Leu Leu Lys Lys Glu Glu His Glu Glu Tyr Ile Asp Leu Ile Glu 
                645                 650                 655     


Leu His Lys Thr Ala Leu Ala Leu Leu Leu Ala Val Thr Glu Thr Gln 
            660                 665                 670         


Leu Asp Ile Ser Ala Leu Asp Phe Val Glu Asn Gly Thr Val Lys Asp 
        675                 680                 685             


Phe Met Lys Thr Arg Asp Gly Asn Leu Val Leu Glu Gly Arg Phe Leu 
    690                 695                 700                 


Glu Met Phe Ser Gln Ser Ile Val Phe Ser Glu Leu Arg Gly Leu Ala 
705                 710                 715                 720 


Gly Leu Met Ser Arg Lys Glu Phe Ile Thr Arg Ser Ala Ile Gln Thr 
                725                 730                 735     


Met Asn Gly Lys Gln Ala Glu Leu Leu Tyr Ile Pro His Glu Phe Gln 
            740                 745                 750         


Ser Ala Lys Ile Thr Thr Pro Lys Glu Met Ser Arg Ala Phe Leu Asp 
        755                 760                 765             


Leu Ala Pro Ala Glu Phe Ala Thr Ser Leu Glu Pro Glu Ser Leu Ser 
    770                 775                 780                 


Glu Lys Ser Leu Leu Lys Leu Lys Gln Met Arg Tyr Tyr Pro His Tyr 
785                 790                 795                 800 


Phe Gly Tyr Glu Leu Thr Arg Thr Gly Gln Gly Ile Asp Gly Gly Val 
                805                 810                 815     


Ala Glu Asn Ala Leu Arg Leu Glu Lys Ser Pro Val Lys Lys Arg Glu 
            820                 825                 830         


Ile Lys Cys Lys Gln Tyr Lys Thr Leu Gly Arg Gly Gln Asn Lys Ile 
        835                 840                 845             


Val Leu Tyr Val Arg Ser Ser Tyr Tyr Gln Thr Gln Phe Leu Glu Trp 
    850                 855                 860                 


Phe Leu His Arg Pro Lys Asn Val Gln Thr Asp Val Ala Val Ser Gly 
865                 870                 875                 880 


Ser Phe Leu Ile Asp Glu Lys Lys Val Lys Thr Arg Trp Asn Tyr Asp 
                885                 890                 895     


Ala Leu Thr Val Ala Leu Glu Pro Val Ser Gly Ser Glu Arg Val Phe 
            900                 905                 910         


Val Ser Gln Pro Phe Thr Ile Phe Pro Glu Lys Ser Ala Glu Glu Glu 
        915                 920                 925             


Gly Gln Arg Tyr Leu Gly Ile Asp Ile Gly Glu Tyr Gly Ile Ala Tyr 
    930                 935                 940                 


Thr Ala Leu Glu Ile Thr Gly Asp Ser Ala Lys Ile Leu Asp Gln Asn 
945                 950                 955                 960 


Phe Ile Ser Asp Pro Gln Leu Lys Thr Leu Arg Glu Glu Val Lys Gly 
                965                 970                 975     


Leu Lys Leu Asp Gln Arg Arg Gly Thr Phe Ala Met Pro Ser Thr Lys 
            980                 985                 990         


Ile Ala Arg Ile Arg Glu Ser Leu  Val His Ser Leu Arg  Asn Arg Ile 
        995                 1000                 1005             


His His  Leu Ala Leu Lys His  Lys Ala Lys Ile Val  Tyr Glu Leu 
    1010                 1015                 1020             


Glu Val  Ser Arg Phe Glu Glu  Gly Lys Gln Lys Ile  Lys Lys Val 
    1025                 1030                 1035             


Tyr Ala  Thr Leu Lys Lys Ala  Asp Val Tyr Ser Glu  Ile Asp Ala 
    1040                 1045                 1050             


Asp Lys  Asn Leu Gln Thr Thr  Val Trp Gly Lys Leu  Ala Val Ala 
    1055                 1060                 1065             


Ser Glu  Ile Ser Ala Ser Tyr  Thr Ser Gln Phe Cys  Gly Ala Cys 
    1070                 1075                 1080             


Lys Lys  Leu Trp Arg Ala Glu  Met Gln Val Asp Glu  Thr Ile Thr 
    1085                 1090                 1095             


Thr Gln  Glu Leu Ile Gly Thr  Val Arg Val Ile Lys  Gly Gly Thr 
    1100                 1105                 1110             


Leu Ile  Asp Ala Ile Lys Asp  Phe Met Arg Pro Pro  Ile Phe Asp 
    1115                 1120                 1125             


Glu Asn  Asp Thr Pro Phe Pro  Lys Tyr Arg Asp Phe  Cys Asp Lys 
    1130                 1135                 1140             


His His  Ile Ser Lys Lys Met  Arg Gly Asn Ser Cys  Leu Phe Ile 
    1145                 1150                 1155             


Cys Pro  Phe Cys Arg Ala Asn  Ala Asp Ala Asp Ile  Gln Ala Ser 
    1160                 1165                 1170             


Gln Thr  Ile Ala Leu Leu Arg  Tyr Val Lys Glu Glu  Lys Lys Val 
    1175                 1180                 1185             


Glu Asp  Tyr Phe Glu Arg Phe  Arg Lys Leu Lys Asn  Ile Lys Val 
    1190                 1195                 1200             


Leu Gly  Gln Met Lys Lys Ile  
    1205                 1210 


<210>  27
<211>  1372
<212>  PRT
<213>  Streptococcus gallolyticus

<400>  27

Met Thr Lys Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Asn Glu Ile Ala Lys Val Asp Glu 
                85                  90                  95      


Ser Phe Phe Gln Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys 
            100                 105                 110         


Thr Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala 
        115                 120                 125             


Tyr His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn 
                165                 170                 175     


Ala Glu Asn Thr Asp Val Gln Lys Ile Phe Ala Asp Phe Val Gly Val 
            180                 185                 190         


Tyr Asn Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp 
        195                 200                 205             


Val Ala Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Leu Ile Lys Tyr Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn 
                245                 250                 255     


Phe Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala 
        275                 280                 285             


Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Lys Arg Tyr Val Glu His His Glu Asp Leu Glu Lys Leu 
                325                 330                 335     


Lys Glu Phe Ile Lys Ala Asn Lys Ser Glu Leu Tyr His Asp Ile Phe 
            340                 345                 350         


Lys Asp Lys Asn Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val 
        355                 360                 365             


Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Ile Leu Ser Lys Ile 
    370                 375                 380                 


Lys Ile Asp Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp 
385                 390                 395                 400 


Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
                405                 410                 415     


Ile His Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr 
            420                 425                 430         


Tyr Pro Phe Leu Lys Glu Lys Gln Asp Arg Ile Glu Lys Ile Leu Thr 
        435                 440                 445             


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Arg Lys Asp Ser Arg 
    450                 455                 460                 


Phe Ala Trp Ala Glu Tyr Arg Ser Asp Glu Lys Ile Thr Pro Trp Asn 
465                 470                 475                 480 


Phe Asp Lys Val Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr 
                485                 490                 495     


Arg Met Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro 
            500                 505                 510         


Lys His Ser His Val Tyr Glu Thr Tyr Ala Val Tyr Asn Glu Leu Thr 
        515                 520                 525             


Lys Ile Lys Tyr Val Asn Glu Gln Gly Lys Glu Ser Phe Phe Asp Ser 
    530                 535                 540                 


Asn Met Lys Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys 
545                 550                 555                 560 


Val Thr Lys Glu Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu 
                565                 570                 575     


Tyr Arg Ile Lys Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe 
            580                 585                 590         


Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys 
        595                 600                 605             


Ala Phe Leu Asp Asp Lys Val Asn Glu Glu Val Ile Glu Asp Ile Ile 
    610                 615                 620                 


Lys Thr Leu Thr Leu Phe Glu Asp Lys Asp Met Ile His Glu Arg Leu 
625                 630                 635                 640 


Gln Lys Tyr Ser Asp Ile Phe Thr Ala Asn Gln Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn 
            660                 665                 670         


Gly Ile Arg Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Tyr Leu Ile 
        675                 680                 685             


Asp Asp Gly Ser Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp 
    690                 695                 700                 


Thr Leu Pro Phe Lys Gln Ile Ile Gln Lys Ser Gln Val Val Gly Asp 
705                 710                 715                 720 


Val Asp Asp Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Lys Val Met Gly Gly Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Asn Arg Gly Arg Ser Gln Ser Gln Gln Arg Leu 
    770                 775                 780                 


Lys Lys Leu Gln Asn Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn 
785                 790                 795                 800 


Glu Glu Lys Pro Ser Tyr Ile Glu Asp Lys Val Glu Asn Ser His Leu 
                805                 810                 815     


Gln Asn Asp Gln Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met 
            820                 825                 830         


Tyr Thr Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile 
        835                 840                 845             


Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn 
    850                 855                 860                 


Arg Val Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val 
865                 870                 875                 880 


Pro Ser Leu Asp Ile Val Arg Ala Arg Lys Ala Glu Trp Val Arg Leu 
                885                 890                 895     


Tyr Lys Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys 
            900                 905                 910         


Ala Glu Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys 
        915                 920                 925             


Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile 
    930                 935                 940                 


Leu Asp Ala Arg Phe Asn Thr Glu His Asp Glu Asn Asp Lys Val Ile 
945                 950                 955                 960 


Arg Asp Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe 
                965                 970                 975     


Arg Lys Asp Phe Glu Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His 
            980                 985                 990         


His Ala His Asp Ala Tyr Leu Asn  Ala Val Val Gly Thr  Ala Leu Leu 
        995                 1000                 1005             


Lys Lys  Tyr Pro Lys Leu Ala  Ser Glu Phe Val Tyr  Gly Glu Tyr 
    1010                 1015                 1020             


Lys Lys  Tyr Asp Ile Arg Lys  Phe Ile Thr Asn Ser  Ser Asp Lys 
    1025                 1030                 1035             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Leu Met  Asn Phe Phe 
    1040                 1045                 1050             


Lys Thr  Lys Val Lys Tyr Ala  Asp Gly Thr Val Phe  Glu Arg Pro 
    1055                 1060                 1065             


Ile Ile  Glu Thr Asn Ala Asp  Gly Glu Ile Ala Trp  Asn Lys Gln 
    1070                 1075                 1080             


Ile Asp  Phe Glu Lys Val Arg  Lys Val Leu Ser Tyr  Pro Gln Val 
    1085                 1090                 1095             


Asn Ile  Val Lys Lys Val Glu  Thr Gln Thr Gly Gly  Phe Ser Lys 
    1100                 1105                 1110             


Glu Ser  Ile Leu Pro Lys Gly  Asp Ser Asp Lys Leu  Ile Pro Arg 
    1115                 1120                 1125             


Lys Thr  Lys Lys Val Tyr Trp  Asp Thr Lys Lys Tyr  Gly Gly Phe 
    1130                 1135                 1140             


Asp Ser  Pro Thr Val Ala Tyr  Ser Val Phe Val Val  Ala Asp Val 
    1145                 1150                 1155             


Glu Lys  Gly Lys Ala Lys Lys  Leu Lys Thr Val Lys  Glu Leu Val 
    1160                 1165                 1170             


Gly Ile  Ser Ile Met Glu Arg  Ser Phe Phe Glu Glu  Asn Pro Val 
    1175                 1180                 1185             


Glu Phe  Leu Glu Asn Lys Gly  Tyr His Asn Ile Arg  Glu Asp Lys 
    1190                 1195                 1200             


Leu Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Phe  Glu Gly Gly 
    1205                 1210                 1215             


Arg Arg  Arg Leu Leu Ala Ser  Ala Ser Glu Leu Gln  Lys Gly Asn 
    1220                 1225                 1230             


Glu Met  Val Leu Pro Gly Tyr  Leu Val Glu Leu Leu  Tyr His Ala 
    1235                 1240                 1245             


His Arg  Ala Asp Asn Phe Asn  Ser Thr Glu Tyr Leu  Asn Tyr Val 
    1250                 1255                 1260             


Ser Glu  His Lys Lys Glu Phe  Glu Lys Val Leu Ser  Cys Val Glu 
    1265                 1270                 1275             


Asp Phe  Ala Asn Leu Tyr Val  Asp Val Glu Lys Asn  Leu Ser Lys 
    1280                 1285                 1290             


Ile Arg  Ala Val Ala Asp Ser  Met Asp Asn Phe Ser  Ile Glu Glu 
    1295                 1300                 1305             


Ile Ser  Asn Ser Phe Ile Asn  Leu Leu Thr Leu Thr  Ala Leu Gly 
    1310                 1315                 1320             


Ala Pro  Ala Asp Phe Asn Phe  Leu Gly Glu Lys Ile  Pro Arg Lys 
    1325                 1330                 1335             


Arg Tyr  Thr Ser Thr Lys Glu  Cys Leu Asn Ala Thr  Leu Ile His 
    1340                 1345                 1350             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Lys 
    1355                 1360                 1365             


Leu Gly  Glu Glu 
    1370         


<210>  28
<211>  1370
<212>  PRT
<213>  Streptococcus mitis

<400>  28

Met Lys Lys Gly Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Phe Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Arg Phe Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Ala Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Ser Lys Val Asp Ser Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Asp Ser Phe Leu Ile Pro Glu Asp Lys Arg 
            100                 105                 110         


Glu Ser Lys Tyr Pro Ile Phe Ala Thr Leu Thr Glu Glu Lys Glu Tyr 
        115                 120                 125             


His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala Asp 
    130                 135                 140                 


Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ala Phe Asp Ile 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln Val 
        195                 200                 205             


Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Asp Leu Glu Asp Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Thr Asp 
        275                 280                 285             


Leu Phe Val Ser Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Glu Arg Tyr Glu Asn His Gln Asn Asp Leu Ala Ala Leu Lys 
                325                 330                 335     


Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe Ser 
            340                 345                 350         


Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Thr 
        355                 360                 365             


Gln Glu Thr Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe Glu 
    370                 375                 380                 


Gly Thr Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala Trp 
    450                 455                 460                 


Leu Thr Arg Asn Ser Asp Glu Ala Ile Arg Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Ile Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly Gln 
    530                 535                 540                 


Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Glu Asn Arg Lys Val Thr 
545                 550                 555                 560 


Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp Asp 
        595                 600                 605             


Ala Lys Asn Glu Ala Ile Leu Glu Asn Ile Val His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp Ser 
625                 630                 635                 640 


Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Cys Asp Lys 
            660                 665                 670         


Gln Thr Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Lys Ile 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe Lys 
    690                 695                 700                 


Glu Ile Ile Gln Lys Ala Gln Val Ile Gly Lys Thr Asp Asp Val Lys 
705                 710                 715                 720 


Gln Val Val Gln Glu Leu Ser Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His 
            740                 745                 750         


Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu Asp 
    770                 775                 780                 


Ser Leu Lys Ile Leu Ala Ser Gly Leu Asp Ser Asn Ile Leu Lys Glu 
785                 790                 795                 800 


Asn Pro Thr Asp Asn Asn Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr 
                805                 810                 815     


Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp Ile 
            820                 825                 830         


Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe 
        835                 840                 845             


Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys Asp 
    850                 855                 860                 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Glu Val Val Gln Lys 
865                 870                 875                 880 


Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser Glu 
                885                 890                 895     


Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp Glu 
            900                 905                 910         


Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Tyr Asn Thr Glu 
    930                 935                 940                 


Val Asn Glu Lys Asp Lys Lys Asn Arg Thr Val Lys Ile Ile Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Arg Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Ala Lys Ala Ile Leu  Lys Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Glu Tyr  Gln Lys Tyr Asp Leu  Lys Arg Tyr 
    1010                 1015                 1020             


Ile Ser  Arg Ser Lys Asp Pro  Lys Glu Val Glu Lys  Ala Thr Glu 
    1025                 1030                 1035             


Lys Tyr  Phe Phe Tyr Ser Asn  Leu Leu Asn Phe Phe  Lys Glu Glu 
    1040                 1045                 1050             


Val His  Tyr Ala Asp Gly Thr  Ile Val Lys Arg Glu  Asn Ile Glu 
    1055                 1060                 1065             


Tyr Ser  Lys Asp Thr Gly Glu  Ile Ala Trp Asn Lys  Glu Lys Asp 
    1070                 1075                 1080             


Phe Ala  Ile Ile Lys Lys Val  Leu Ser Leu Pro Gln  Val Asn Ile 
    1085                 1090                 1095             


Val Lys  Lys Arg Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1100                 1105                 1110             


Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu Ile Pro  Arg Lys Thr 
    1115                 1120                 1125             


Lys Asp  Ile Leu Leu Asp Thr  Thr Lys Tyr Gly Gly  Phe Asp Ser 
    1130                 1135                 1140             


Pro Val  Ile Ala Tyr Ser Ile  Leu Leu Ile Ala Asp  Ile Glu Lys 
    1145                 1150                 1155             


Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys Thr Leu  Val Gly Ile 
    1160                 1165                 1170             


Thr Ile  Met Glu Lys Ala Ala  Phe Glu Glu Asn Pro  Ile Thr Phe 
    1175                 1180                 1185             


Leu Glu  Asn Lys Gly Tyr His  Asn Val Arg Lys Glu  Asn Ile Leu 
    1190                 1195                 1200             


Cys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Arg 
    1205                 1210                 1215             


Arg Leu  Leu Ala Ser Ala Lys  Glu Leu Gln Lys Gly  Asn Glu Ile 
    1220                 1225                 1230             


Val Leu  Pro Val Tyr Leu Thr  Thr Leu Leu Tyr His  Ser Lys Asn 
    1235                 1240                 1245             


Val His  Lys Leu Asp Glu Pro  Gly His Leu Glu Tyr  Ile Gln Lys 
    1250                 1255                 1260             


His Arg  Asn Glu Phe Lys Asp  Leu Leu Asn Leu Val  Ser Glu Phe 
    1265                 1270                 1275             


Ser Gln  Lys Tyr Val Leu Ala  Asp Ala Asn Leu Glu  Lys Ile Lys 
    1280                 1285                 1290             


Ser Leu  Tyr Ala Asp Asn Glu  Gln Ala Asp Ile Glu  Ile Leu Ala 
    1295                 1300                 1305             


Asn Ser  Phe Ile Asn Leu Leu  Thr Phe Thr Ala Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Gly  Lys Asp Ile Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Thr  Val Ser Glu Ile Leu  Asn Ala Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Trp Ile Asp Leu Ser  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  29
<211>  1056
<212>  PRT
<213>  Staphylococcus aureus

<400>  29

Gly Ser His Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile 
1               5                   10                  15      


Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile 
            20                  25                  30          


Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu 
        35                  40                  45              


Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg 
    50                  55                  60                  


His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu 
65                  70                  75                  80  


Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val 
                85                  90                  95      


Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu 
            100                 105                 110         


Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu 
        115                 120                 125             


Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn 
    130                 135                 140                 


Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg 
145                 150                 155                 160 


Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr 
                165                 170                 175     


Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala 
            180                 185                 190         


Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu 
        195                 200                 205             


Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe 
    210                 215                 220                 


Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys 
225                 230                 235                 240 


Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala 
                245                 250                 255     


Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg 
            260                 265                 270         


Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu 
        275                 280                 285             


Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys 
    290                 295                 300                 


Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser 
305                 310                 315                 320 


Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys 
                325                 330                 335     


Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp 
            340                 345                 350         


Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln 
        355                 360                 365             


Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu 
    370                 375                 380                 


Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu 
385                 390                 395                 400 


Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn 
                405                 410                 415     


Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp 
            420                 425                 430         


Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile 
        435                 440                 445             


Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile 
    450                 455                 460                 


Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu 
465                 470                 475                 480 


Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu 
                485                 490                 495     


Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile 
            500                 505                 510         


Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys 
        515                 520                 525             


Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile 
    530                 535                 540                 


Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His 
545                 550                 555                 560 


Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val 
                565                 570                 575     


Leu Val Lys Gln Glu Glu Ala Ser Lys Lys Gly Asn Arg Thr Pro Phe 
            580                 585                 590         


Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys 
        595                 600                 605             


Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr 
    610                 615                 620                 


Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val 
625                 630                 635                 640 


Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr 
                645                 650                 655     


Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu 
            660                 665                 670         


Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg 
        675                 680                 685             


Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His 
    690                 695                 700                 


Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu 
705                 710                 715                 720 


Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe 
                725                 730                 735     


Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu 
            740                 745                 750         


Tyr Lys Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp 
        755                 760                 765             


Phe Lys Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
    770                 775                 780                 


Glu Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly 
785                 790                 795                 800 


Asn Thr Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn 
                805                 810                 815     


Asp Lys Leu Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met 
            820                 825                 830         


Tyr His His Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu 
        835                 840                 845             


Gln Tyr Gly Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr 
    850                 855                 860                 


Gly Asn Tyr Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile 
865                 870                 875                 880 


Lys Lys Ile Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile 
                885                 890                 895     


Thr Asp Asp Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu 
            900                 905                 910         


Lys Pro Tyr Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe 
        915                 920                 925             


Val Thr Val Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu 
    930                 935                 940                 


Val Asn Ser Lys Ala Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser 
945                 950                 955                 960 


Asn Gln Ala Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys 
                965                 970                 975     


Ile Asn Gly Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu 
            980                 985                 990         


Asn Arg Ile Glu Val Asn Met Ile  Asp Ile Thr Tyr Arg  Glu Tyr Leu 
        995                 1000                 1005             


Glu Asn  Met Asn Asp Lys Arg  Pro Pro Arg Ile Ile  Lys Thr Ile 
    1010                 1015                 1020             


Ala Ser  Lys Thr Gln Ser Ile  Lys Lys Tyr Ser Thr  Asp Ile Leu 
    1025                 1030                 1035             


Gly Asn  Leu Tyr Glu Val Lys  Ser Lys Lys His Pro  Gln Ile Ile 
    1040                 1045                 1050             


Lys Lys  Gly 
    1055     


<210>  30
<211>  1052
<212>  PRT
<213>  S. pyogenes

<400>  30

Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
1               5                   10                  15      


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            20                  25                  30          


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        35                  40                  45              


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    50                  55                  60                  


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu 
65                  70                  75                  80  


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                85                  90                  95      


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            100                 105                 110         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        115                 120                 125             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    130                 135                 140                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
145                 150                 155                 160 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                165                 170                 175     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            180                 185                 190         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        195                 200                 205             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    210                 215                 220                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
225                 230                 235                 240 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                245                 250                 255     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            260                 265                 270         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        275                 280                 285             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    290                 295                 300                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
305                 310                 315                 320 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                325                 330                 335     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            340                 345                 350         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        355                 360                 365             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    370                 375                 380                 


Ser Leu Thr Phe Lys Glu Asp Leu Gln Lys Ala Gln Val Ser Gly Gln 
385                 390                 395                 400 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                405                 410                 415     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            420                 425                 430         


Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala 
        435                 440                 445             


Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg 
    450                 455                 460                 


Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu 
465                 470                 475                 480 


Lys Glu Tyr Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr 
                485                 490                 495     


Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu 
            500                 505                 510         


Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln 
        515                 520                 525             


Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser 
    530                 535                 540                 


Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val 
545                 550                 555                 560 


Lys Lys Met Lys Asn Tyr Trp Lys Gln Leu Leu Asn Ala Lys Leu Ile 
                565                 570                 575     


Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu 
            580                 585                 590         


Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr 
        595                 600                 605             


Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn 
    610                 615                 620                 


Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile 
625                 630                 635                 640 


Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe 
                645                 650                 655     


Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr 
            660                 665                 670         


Leu Asn Ala Val Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu 
        675                 680                 685             


Glu Ser Glu Phe Val Tyr Gly Asp Tyr Lys Val Tyr Asp Ile Arg Lys 
    690                 695                 700                 


Met Ile Ala Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr 
705                 710                 715                 720 


Phe Phe Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu 
                725                 730                 735     


Ala Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 
            740                 745                 750         


Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg 
        755                 760                 765             


Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val 
    770                 775                 780                 


Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser 
785                 790                 795                 800 


Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly 
                805                 810                 815     


Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys 
            820                 825                 830         


Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Val 
        835                 840                 845             


Gly Ile Thr Ile Met Glu Arg Ser Ser Phe Glu Lys Asp Pro Val Asp 
    850                 855                 860                 


Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val Arg Lys Asp Leu Ile Ile 
865                 870                 875                 880 


Lys Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg 
                885                 890                 895     


Met Leu Ala Ser Ala Gly Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu 
            900                 905                 910         


Pro Ser Lys Tyr Val Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys 
        915                 920                 925             


Leu Lys Gly Ser Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu 
    930                 935                 940                 


Gln His Lys His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe 
945                 950                 955                 960 


Ser Lys Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser 
                965                 970                 975     


Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn 
            980                 985                 990         


Ile Ile His Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
        995                 1000                 1005             


Lys Cys  Phe Asp Thr Thr Ile  Gly Arg Asn Arg Tyr  Lys Ser Ile 
    1010                 1015                 1020             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1025                 1030                 1035             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1040                 1045                 1050         


<210>  31
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  31

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  32
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  32

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Leu 
            20                  25                  30          


Lys Gly Leu Gly Asn Thr Asp Arg His Gly Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Val Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  33
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  33

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asn Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Val Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Phe Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  34
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  34

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  35
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  35

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Ile Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Val Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Leu Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Thr Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Phe Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  36
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  36

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Ile Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Leu Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Thr Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Lys Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Ile Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Val Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Val Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Cys Phe Asp Thr Thr  Ile Gly Arg Asn Arg  Tyr Lys Ser 
    1325                 1330                 1335             


Ile Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  37
<211>  1367
<212>  PRT
<213>  S. pyogenes

<400>  37

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Gly Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Ile Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Ala Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Gly Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  38
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  38

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Leu Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  39
<211>  1367
<212>  PRT
<213>  S. pyogenes

<400>  39

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Leu 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Gly Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Val Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Thr Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Lys Tyr Ala 
625                 630                 635                 640 


Asn Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Arg  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Lys Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Glu Arg Asn Arg Tyr  Lys Ser Ile 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  40
<211>  1367
<212>  PRT
<213>  S. pyogenes

<400>  40

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Leu 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Gly Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Val Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Thr Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Lys Tyr Ala 
625                 630                 635                 640 


Asn Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Arg  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Lys Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Glu Arg Asn Arg Tyr  Lys Ser Ile 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Ile Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  41
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  41

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Ser Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Leu Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Gly Arg Asn Arg  Tyr Lys Ser 
    1325                 1330                 1335             


Ile Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  42
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  42

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Gly Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Val Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  43
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  43

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Lys Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Phe Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Ile  Tyr Phe Asp Thr Thr  Ile Gly Arg Asn Arg  Tyr Lys Ser 
    1325                 1330                 1335             


Ile Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  44
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  44

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Ile Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Leu Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Lys Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Ile Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Val Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Val Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Gly Arg Asn Arg  Tyr Lys Ser 
    1325                 1330                 1335             


Ile Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  45
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  45

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Ile Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gly Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Leu Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Lys Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Ile Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Val Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Val Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Gly Arg Asn Arg  Tyr Lys Ser 
    1325                 1330                 1335             


Ile Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  46
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  46

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Asn Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  47
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  47

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Leu Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Lys Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Lys Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  48
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  48

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Ile Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Lys Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Leu Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Thr Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Phe Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  49
<211>  1193
<212>  PRT
<213>  S. pyogenes

<400>  49

Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr 
1               5                   10                  15      


Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp 
            20                  25                  30          


Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu 
        35                  40                  45              


Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly 
    50                  55                  60                  


Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn 
65                  70                  75                  80  


Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr 
                85                  90                  95      


Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala 
            100                 105                 110         


Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser 
        115                 120                 125             


Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala 
    130                 135                 140                 


Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu 
145                 150                 155                 160 


Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe 
                165                 170                 175     


Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala 
            180                 185                 190         


Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met 
        195                 200                 205             


Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu 
    210                 215                 220                 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
225                 230                 235                 240 


Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro 
                245                 250                 255     


Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
            260                 265                 270         


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala 
        275                 280                 285             


Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu 
    290                 295                 300                 


Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met 
305                 310                 315                 320 


Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His 
                325                 330                 335     


Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
            340                 345                 350         


Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu 
        355                 360                 365             


Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val 
    370                 375                 380                 


Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe 
385                 390                 395                 400 


Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu 
                405                 410                 415     


Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu 
            420                 425                 430         


Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu 
        435                 440                 445             


Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr 
    450                 455                 460                 


Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg 
465                 470                 475                 480 


Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg 
                485                 490                 495     


Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly 
            500                 505                 510         


Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr 
        515                 520                 525             


Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser 
    530                 535                 540                 


Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys 
545                 550                 555                 560 


Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met 
                565                 570                 575     


Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
            580                 585                 590         


Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg 
        595                 600                 605             


Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His 
    610                 615                 620                 


Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr 
625                 630                 635                 640 


Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn 
                645                 650                 655     


Arg Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu 
            660                 665                 670         


Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn 
        675                 680                 685             


Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met 
    690                 695                 700                 


Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg 
705                 710                 715                 720 


Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu 
                725                 730                 735     


Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile 
            740                 745                 750         


Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr 
        755                 760                 765             


Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys 
    770                 775                 780                 


Ser Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val 
785                 790                 795                 800 


Arg Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala 
                805                 810                 815     


Val Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu 
            820                 825                 830         


Phe Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala 
        835                 840                 845             


Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr 
    850                 855                 860                 


Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly 
865                 870                 875                 880 


Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu 
                885                 890                 895     


Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu 
            900                 905                 910         


Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly 
        915                 920                 925             


Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu 
    930                 935                 940                 


Ile Ala Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp 
945                 950                 955                 960 


Ser Pro Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys 
                965                 970                 975     


Gly Lys Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr 
            980                 985                 990         


Ile Met Glu Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
        995                 1000                 1005             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1010                 1015                 1020             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1025                 1030                 1035             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1040                 1045                 1050             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1055                 1060                 1065             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1070                 1075                 1080             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1085                 1090                 1095             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1100                 1105                 1110             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1115                 1120                 1125             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1130                 1135                 1140             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1145                 1150                 1155             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1160                 1165                 1170             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1175                 1180                 1185             


Gln Leu  Gly Gly Asp 
    1190             


<210>  50
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  50

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  51
<211>  1367
<212>  PRT
<213>  S. pyogenes

<400>  51

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Val Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Thr Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Thr Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Lys Tyr Ala 
625                 630                 635                 640 


Asn Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Arg  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Lys Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Glu Arg Asn Arg Tyr  Lys Ser Ile 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  52
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  52

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Leu Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Lys Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Gly Arg Asn Arg  Tyr Lys Ser 
    1325                 1330                 1335             


Ile Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  53
<211>  1279
<212>  PRT
<213>  S. pyogenes

<400>  53

Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
1               5                   10                  15      


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
            20                  25                  30          


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
        35                  40                  45              


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
65                  70                  75                  80  


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
                85                  90                  95      


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
            100                 105                 110         


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
        115                 120                 125             


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
    130                 135                 140                 


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
145                 150                 155                 160 


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
                165                 170                 175     


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
            180                 185                 190         


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
        195                 200                 205             


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
    210                 215                 220                 


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
225                 230                 235                 240 


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
                245                 250                 255     


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
            260                 265                 270         


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
        275                 280                 285             


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
    290                 295                 300                 


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
305                 310                 315                 320 


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
                325                 330                 335     


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
            340                 345                 350         


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
        355                 360                 365             


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
    370                 375                 380                 


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
385                 390                 395                 400 


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
                405                 410                 415     


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
            420                 425                 430         


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
        435                 440                 445             


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
    450                 455                 460                 


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
465                 470                 475                 480 


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
                485                 490                 495     


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
            500                 505                 510         


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
        515                 520                 525             


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
    530                 535                 540                 


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
545                 550                 555                 560 


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
                565                 570                 575     


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
            580                 585                 590         


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
        595                 600                 605             


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
    610                 615                 620                 


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
625                 630                 635                 640 


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
                645                 650                 655     


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
            660                 665                 670         


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
        675                 680                 685             


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
    690                 695                 700                 


Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu 
705                 710                 715                 720 


Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp 
                725                 730                 735     


Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile 
            740                 745                 750         


Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu 
        755                 760                 765             


Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu 
    770                 775                 780                 


Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala 
785                 790                 795                 800 


Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
                805                 810                 815     


Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu 
            820                 825                 830         


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser 
        835                 840                 845             


Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val 
    850                 855                 860                 


Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp 
865                 870                 875                 880 


Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala His 
                885                 890                 895     


Asp Ala Tyr Leu Asn Ala Val Val Gly Thr Ala Leu Ile Lys Lys Tyr 
            900                 905                 910         


Pro Lys Leu Glu Ser Glu Phe Val Tyr Gly Asp Tyr Lys Val Tyr Asp 
        915                 920                 925             


Val Arg Lys Met Ile Ala Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr 
    930                 935                 940                 


Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu 
945                 950                 955                 960 


Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr 
                965                 970                 975     


Asn Gly Glu Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala 
            980                 985                 990         


Thr Val Arg Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
        995                 1000                 1005             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1010                 1015                 1020             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1025                 1030                 1035             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1040                 1045                 1050             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1055                 1060                 1065             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1070                 1075                 1080             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1085                 1090                 1095             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1100                 1105                 1110             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1115                 1120                 1125             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1130                 1135                 1140             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1145                 1150                 1155             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1160                 1165                 1170             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1175                 1180                 1185             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1190                 1195                 1200             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1205                 1210                 1215             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1220                 1225                 1230             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1235                 1240                 1245             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1250                 1255                 1260             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1265                 1270                 1275             


Asp 
    


<210>  54
<211>  543
<212>  PRT
<213>  S. pyogenes

<400>  54

Gln Glu Leu Asp Ile Asn Arg Leu Ser Gly Tyr Asp Val Asp His Ile 
1               5                   10                  15      


Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu 
            20                  25                  30          


Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu 
        35                  40                  45              


Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala 
    50                  55                  60                  


Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
65                  70                  75                  80  


Gly Gly Leu Ser Glu Leu Asp Lys Val Gly Phe Ile Lys Arg Gln Leu 
                85                  90                  95      


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser 
            100                 105                 110         


Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val 
        115                 120                 125             


Arg Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp 
    130                 135                 140                 


Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala His 
145                 150                 155                 160 


Asp Ala Tyr Leu Asn Ala Val Val Gly Thr Ala Leu Ile Lys Lys Tyr 
                165                 170                 175     


Pro Lys Leu Glu Ser Glu Phe Val Tyr Gly Asp Tyr Lys Val Tyr Asp 
            180                 185                 190         


Val Arg Lys Met Ile Ala Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr 
        195                 200                 205             


Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu 
    210                 215                 220                 


Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr 
225                 230                 235                 240 


Asn Gly Glu Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala 
                245                 250                 255     


Thr Val Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys 
            260                 265                 270         


Thr Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys 
        275                 280                 285             


Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro Lys 
    290                 295                 300                 


Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu Val 
305                 310                 315                 320 


Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser Val Lys 
                325                 330                 335     


Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser Phe Glu Lys Asp 
            340                 345                 350         


Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val Arg Lys Asp 
        355                 360                 365             


Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu Asn Gly 
    370                 375                 380                 


Arg Lys Arg Met Leu Ala Ser Ala Gly Glu Leu Gln Lys Gly Asn Glu 
385                 390                 395                 400 


Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu Tyr Leu Ala Ser His 
                405                 410                 415     


Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn Glu Gln Lys Gln Leu 
            420                 425                 430         


Phe Val Glu Gln His Lys His Tyr Leu Asp Glu Ile Ile Glu Gln Ile 
        435                 440                 445             


Ser Glu Phe Ser Lys Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys 
    450                 455                 460                 


Val Leu Ser Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln 
465                 470                 475                 480 


Ala Glu Asn Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro 
                485                 490                 495     


Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr 
            500                 505                 510         


Ser Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr 
        515                 520                 525             


Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp 
    530                 535                 540             


<210>  55
<211>  306
<212>  PRT
<213>  S. pyogenes

<400>  55

Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp Lys Gly Arg 
1               5                   10                  15      


Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile 
            20                  25                  30          


Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile 
        35                  40                  45              


Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp 
    50                  55                  60                  


Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser 
65                  70                  75                  80  


Val Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys 
                85                  90                  95      


Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser Phe 
            100                 105                 110         


Glu Lys Asp Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val 
        115                 120                 125             


Arg Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Glu Leu 
    130                 135                 140                 


Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu Leu Gln Lys 
145                 150                 155                 160 


Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu Tyr Leu 
                165                 170                 175     


Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn Glu Gln 
            180                 185                 190         


Lys Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp Glu Ile Ile 
        195                 200                 205             


Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala Asp Ala Asn 
    210                 215                 220                 


Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His Arg Asp Lys Pro Ile 
225                 230                 235                 240 


Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu Thr Asn Leu 
                245                 250                 255     


Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys 
            260                 265                 270         


Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln 
        275                 280                 285             


Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly 
    290                 295                 300                 


Gly Asp 
305     


<210>  56
<211>  1368
<212>  PRT
<213>  Unknown

<220>
<223>  MULTISPECIES: type II CRISPR RNA-guided endonuclease Cas9 
       [Streptococcus]

<400>  56

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Ile Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Leu Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Thr Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Phe Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  57
<211>  1345
<212>  PRT
<213>  Unknown

<220>
<223>  MULTISPECIES: type II CRISPR RNA-guided endonuclease Cas9 
       [Streptococcus]

<400>  57

Met Asp Gln Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Asn Lys Val Asp Glu Asn 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Asp Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Ile Ala Ala Glu Val Lys Tyr 
        115                 120                 125             


His Asp Asp Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ile Ser Gln Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asn Val Gln Ala Leu Phe Lys Asp Phe Val Glu Val Tyr 
            180                 185                 190         


Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Met Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala His Tyr Pro Ala Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Leu Leu Gly Glu Ile Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Leu Lys 
                325                 330                 335     


Asp Phe Ile Lys Val Asn Ala Pro Asp Gln Tyr Asn Ala Ile Phe Lys 
            340                 345                 350         


Asp Lys Asn Lys Lys Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Gln Ile Asn 
    370                 375                 380                 


Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Glu Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp 
465                 470                 475                 480 


Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Val Asn Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ser Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asp Lys Ala Asn Glu Lys Thr Ile Glu Asp Ile Ile Gln Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Lys Ala Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Arg Ala Gln Ile Ile Gly Asp Val Asp Asp 
705                 710                 715                 720 


Ile Ala Asn Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly His Asn Pro Ala Asn Ile Ile Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Met Thr Asp Lys Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Asn Leu Asp Asn Pro Val Asn Ile Lys Asn Val 
785                 790                 795                 800 


Glu Asn Gln Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu 
            820                 825                 830         


Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp 
        835                 840                 845             


Asn Ser Leu Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Ile Glu Val Val His Glu Met Lys Ser 
865                 870                 875                 880 


Phe Trp Ser Lys Leu Leu Ser Val Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Glu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Glu Arg Phe Asn Thr Glu Phe Asp Gly 
    930                 935                 940                 


Asn Lys Arg Arg Ile Arg Asn Val Lys Ile Ile Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Asn Ala Leu Leu Leu Lys Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Glu Tyr Pro Lys Tyr  Asn Ser Tyr Arg Ser  Arg Lys Ser 
    1010                 1015                 1020             


Ala Thr  Glu Lys Phe Leu Phe  Tyr Ser Asn Ile Leu  Arg Phe Phe 
    1025                 1030                 1035             


Lys Lys  Glu Asp Ile Gln Thr  Asn Glu Asp Gly Glu  Ile Ala Trp 
    1040                 1045                 1050             


Asn Lys  Glu Lys His Ile Lys  Ile Leu Arg Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Glu Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Asn  Ser Tyr Trp Asn Pro  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Val  Val Ala Tyr Ser Ile  Leu Val Phe 
    1115                 1120                 1125             


Ala Asp  Val Glu Lys Gly Lys  Ser Lys Lys Leu Arg  Lys Val Gln 
    1130                 1135                 1140             


Asp Met  Val Gly Ile Thr Ile  Met Glu Lys Lys Arg  Phe Glu Lys 
    1145                 1150                 1155             


His Pro  Val Asp Phe Leu Glu  Gln Arg Gly Tyr Arg  Asn Val Arg 
    1160                 1165                 1170             


Leu Glu  Lys Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1175                 1180                 1185             


Glu Asn  Lys Arg Arg Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Leu Val Ile  Pro Gln Arg Phe Thr  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ser Tyr Gln Ile Glu  Lys Asn Tyr Glu Pro  Glu His Arg 
    1220                 1225                 1230             


Glu Tyr  Val Glu Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Glu 
    1235                 1240                 1245             


Tyr Ile  Ser Val Phe Ser Arg  Lys Tyr Val Leu Ala  Asp Asn Asn 
    1250                 1255                 1260             


Leu Thr  Lys Ile Glu Met Leu  Phe Ser Lys Asn Lys  Asp Ala Glu 
    1265                 1270                 1275             


Val Ser  Ser Leu Ala Lys Ser  Phe Ile Ser Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Phe  Gly Ala Pro Ala Ala  Phe Asn Phe Phe Gly  Glu Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Val Thr Glu Cys Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Glu Asp  
    1340                 1345 


<210>  58
<211>  1373
<212>  PRT
<213>  Unknown

<220>
<223>  MULTISPECIES: type II CRISPR RNA-guided endonuclease Cas9 
       [Streptococcus]

<400>  58

Met Thr Lys Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Thr Lys Val Asp Glu 
                85                  90                  95      


Ser Phe Phe Gln Arg Leu Asp Glu Ser Phe Leu Arg Trp Asp Asp Asp 
            100                 105                 110         


Asn Lys Lys Leu Gly Arg Tyr Pro Ile Phe Gly Asn Lys Ala Asp Val 
        115                 120                 125             


Val Lys Tyr His Gln Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His 
    130                 135                 140                 


Leu Ala Asp Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala 
145                 150                 155                 160 


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu 
                165                 170                 175     


Leu Asn Ala Glu Asn Thr Asp Val Gln Lys Ile Phe Ala Asp Phe Val 
            180                 185                 190         


Gly Val Tyr Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr 
        195                 200                 205             


Val Asp Ala Ala Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg 
    210                 215                 220                 


Leu Glu Asn Leu Ile Lys Tyr Tyr Pro Thr Glu Lys Lys Asn Thr Leu 
225                 230                 235                 240 


Phe Gly Asn Leu Ile Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys 
                245                 250                 255     


Met Asn Phe Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp 
            260                 265                 270         


Ser Tyr Glu Glu Asp Leu Gly Glu Leu Leu Gly Lys Ile Gly Asp Asp 
        275                 280                 285             


Tyr Ala Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu 
    290                 295                 300                 


Leu Ser Gly Ile Leu Ile Val Asp Asp Asn Ser Thr Lys Ala Pro Leu 
305                 310                 315                 320 


Ser Ala Ser Met Ile Lys Arg Tyr Val Glu His Gln Glu Asp Leu Glu 
                325                 330                 335     


Lys Leu Lys Glu Phe Ile Lys Ala Asn Lys Ser Glu Leu Tyr His Asp 
            340                 345                 350         


Ile Phe Lys Asp Lys Asn Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn 
        355                 360                 365             


Gly Val Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser 
    370                 375                 380                 


Lys Ile Ala Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp 
385                 390                 395                 400 


Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
                405                 410                 415     


Ile His Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr 
            420                 425                 430         


Tyr Pro Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr 
        435                 440                 445             


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asp Ser Arg 
    450                 455                 460                 


Phe Ser Trp Ala Glu Tyr His Ser Asp Glu Lys Ile Thr Pro Trp Asn 
465                 470                 475                 480 


Phe Asp Lys Val Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr 
                485                 490                 495     


Arg Met Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro 
            500                 505                 510         


Lys His Ser His Val Tyr Glu Thr Tyr Ala Val Tyr Asn Glu Leu Thr 
        515                 520                 525             


Lys Ile Lys Tyr Val Asn Glu Gln Gly Lys Asp Ser Phe Phe Asp Ser 
    530                 535                 540                 


Asn Met Lys Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys 
545                 550                 555                 560 


Val Thr Lys Glu Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu 
                565                 570                 575     


Tyr Arg Ile Lys Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe 
            580                 585                 590         


Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys 
        595                 600                 605             


Ala Phe Leu Asp Asp Lys Val Asn Glu Glu Val Ile Glu Asp Ile Ile 
    610                 615                 620                 


Lys Thr Leu Thr Leu Phe Glu Asp Lys Asp Met Ile His Glu Arg Leu 
625                 630                 635                 640 


Gln Lys Tyr Ser Asp Ile Phe Thr Ala Asp Gln Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn 
            660                 665                 670         


Gly Ile Arg Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Tyr Leu Ile 
        675                 680                 685             


Asp Asp Gly Ser Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp 
    690                 695                 700                 


Thr Leu Pro Phe Lys Gln Ile Ile Gln Lys Ser Gln Val Val Gly Asp 
705                 710                 715                 720 


Val Asp Asp Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Lys Val Met Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Asn Arg Gly Arg Ser Gln Ser Gln Gln Arg Leu 
    770                 775                 780                 


Lys Lys Leu Gln Asn Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn 
785                 790                 795                 800 


Glu Glu Lys Pro Ser Tyr Ile Glu Asp Lys Val Glu Asn Ser His Leu 
                805                 810                 815     


Gln Asn Asp Gln Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met 
            820                 825                 830         


Tyr Thr Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile 
        835                 840                 845             


Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn 
    850                 855                 860                 


Arg Val Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val 
865                 870                 875                 880 


Pro Ser Leu Asp Ile Val Arg Ala Arg Lys Ala Glu Trp Val Arg Leu 
                885                 890                 895     


Tyr Lys Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys 
            900                 905                 910         


Ala Glu Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys 
        915                 920                 925             


Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile 
    930                 935                 940                 


Leu Asp Ala Arg Phe Asn Thr Glu Ser Asp Glu Asn Asp Lys Val Ile 
945                 950                 955                 960 


Arg Asp Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe 
                965                 970                 975     


Arg Lys Asp Phe Glu Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His 
            980                 985                 990         


His Ala His Asp Ala Tyr Leu Asn  Ala Val Val Gly Thr  Ala Leu Leu 
        995                 1000                 1005             


Lys Lys  Tyr Pro Lys Leu Ala  Ser Glu Phe Val Tyr  Gly Glu Tyr 
    1010                 1015                 1020             


Lys Lys  Tyr Asp Ile Arg Lys  Phe Ile Thr Asn Ser  Ser Asp Lys 
    1025                 1030                 1035             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Leu Met  Asn Phe Phe 
    1040                 1045                 1050             


Lys Arg  Val Ile Arg Tyr Ser  Asn Gly Lys Val Ile  Val Arg Pro 
    1055                 1060                 1065             


Val Val  Glu Tyr Ser Lys Asp  Thr Glu Asp Ile Ala  Trp Asp Lys 
    1070                 1075                 1080             


Lys Ser  Asn Phe Arg Thr Ile  Cys Lys Val Leu Ser  Tyr Pro Gln 
    1085                 1090                 1095             


Val Asn  Ile Val Lys Lys Val  Glu Thr Gln Thr Gly  Gly Phe Ser 
    1100                 1105                 1110             


Lys Glu  Ser Ile Leu Pro Lys  Gly Asp Ser Asp Lys  Leu Ile Pro 
    1115                 1120                 1125             


Arg Lys  Thr Lys Lys Ala Tyr  Trp Asp Thr Lys Lys  Tyr Gly Gly 
    1130                 1135                 1140             


Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val Phe Val  Val Ala Asp 
    1145                 1150                 1155             


Val Glu  Lys Gly Lys Ala Lys  Lys Leu Lys Thr Val  Lys Glu Leu 
    1160                 1165                 1170             


Val Gly  Ile Ser Ile Met Glu  Arg Ser Phe Phe Glu  Glu Asn Pro 
    1175                 1180                 1185             


Val Glu  Phe Leu Glu Asn Lys  Gly Tyr His Asn Ile  Arg Glu Asp 
    1190                 1195                 1200             


Lys Leu  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Phe Glu Gly 
    1205                 1210                 1215             


Gly Lys  Arg Arg Leu Leu Ala  Ser Ala Ser Glu Leu  Gln Lys Gly 
    1220                 1225                 1230             


Asn Glu  Met Val Ile Pro Gly  His Leu Val Lys Leu  Leu Tyr His 
    1235                 1240                 1245             


Ala Gln  Arg Ile Asn Ser Phe  Asn Ser Thr Lys Tyr  Leu Asp Tyr 
    1250                 1255                 1260             


Val Ser  Ala His Lys Lys Glu  Phe Glu Lys Val Leu  Ser Cys Val 
    1265                 1270                 1275             


Glu Asp  Phe Ala Asn Leu Tyr  Val Asp Val Glu Lys  Asn Leu Ser 
    1280                 1285                 1290             


Lys Ile  Arg Ala Val Ala Asp  Ser Met Asp Asn Phe  Ser Ile Glu 
    1295                 1300                 1305             


Glu Ile  Ser Asn Ser Phe Ile  Asn Leu Leu Thr Leu  Thr Ala Leu 
    1310                 1315                 1320             


Gly Ala  Pro Ala Asp Phe Asn  Phe Leu Gly Glu Lys  Ile Pro Arg 
    1325                 1330                 1335             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Cys Leu Asn Ala  Thr Leu Ile 
    1340                 1345                 1350             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1355                 1360                 1365             


Lys Ile  Gly Glu Glu 
    1370             


<210>  59
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  59

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Ile 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asp Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Val 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Ala Gly Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Ile Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Ser Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Asp Glu 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Val 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Thr Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Phe Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Arg 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  60
<211>  1378
<212>  PRT
<213>  Streptococcus agalactiae

<400>  60

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Gln Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Leu Tyr Arg Arg  Lys Lys Leu 
    1010                 1015                 1020             


Ser Lys  Ile Val Arg Glu Asp  Lys Glu Glu Lys Tyr  Ser Glu Ala 
    1025                 1030                 1035             


Thr Arg  Lys Met Phe Phe Tyr  Ser Asn Leu Met Asn  Met Phe Lys 
    1040                 1045                 1050             


Arg Val  Val Arg Leu Ala Asp  Gly Ser Ile Val Val  Arg Pro Val 
    1055                 1060                 1065             


Ile Glu  Thr Gly Arg Tyr Met  Gly Lys Thr Ala Trp  Asp Lys Lys 
    1070                 1075                 1080             


Lys His  Phe Ala Thr Val Arg  Lys Val Leu Ser Tyr  Pro Gln Val 
    1085                 1090                 1095             


Asn Ile  Val Lys Lys Thr Glu  Ile Gln Thr Gly Gly  Phe Ser Lys 
    1100                 1105                 1110             


Glu Ser  Ile Leu Ala His Gly  Asn Ser Asp Lys Leu  Ile Pro Arg 
    1115                 1120                 1125             


Lys Thr  Lys Asp Ile Tyr Leu  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1130                 1135                 1140             


Asp Ser  Pro Ile Val Ala Tyr  Ser Val Leu Val Val  Ala Asp Ile 
    1145                 1150                 1155             


Lys Lys  Gly Lys Ala Gln Lys  Leu Lys Thr Val Thr  Glu Leu Leu 
    1160                 1165                 1170             


Gly Ile  Thr Ile Met Glu Arg  Ser Lys Phe Glu Lys  Asn Pro Ser 
    1175                 1180                 1185             


Ala Phe  Leu Glu Ser Lys Gly  Tyr Leu Asn Ile Arg  Asp Asp Lys 
    1190                 1195                 1200             


Leu Met  Ile Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1205                 1210                 1215             


Arg Arg  Arg Leu Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1220                 1225                 1230             


Glu Leu  Ala Leu Pro Thr Gln  Phe Met Lys Phe Leu  Tyr Leu Ala 
    1235                 1240                 1245             


Ser Arg  Tyr Asn Glu Ser Lys  Gly Lys Pro Glu Glu  Ile Glu Lys 
    1250                 1255                 1260             


Lys Gln  Glu Phe Val Asn Gln  His Val Ser Tyr Phe  Asp Asp Ile 
    1265                 1270                 1275             


Leu Gln  Leu Ile Asn Asp Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1280                 1285                 1290             


Ala Asn  Leu Glu Lys Ile Asn  Lys Leu Tyr Gln Asp  Asn Lys Glu 
    1295                 1300                 1305             


Asn Ile  Ser Val Asp Glu Leu  Ala Asn Asn Ile Ile  Asn Leu Phe 
    1310                 1315                 1320             


Thr Phe  Thr Ser Leu Gly Ala  Pro Ala Ala Phe Lys  Phe Phe Asp 
    1325                 1330                 1335             


Lys Ile  Val Asp Arg Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu 
    1340                 1345                 1350             


Asn Ser  Thr Leu Ile His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr 
    1355                 1360                 1365             


Arg Ile  Asp Leu Ser Lys Leu  Gly Glu Asp 
    1370                 1375             


<210>  61
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  61

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Ile Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  62
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  62

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Ile Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  63
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  63

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Ile Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  64
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  64

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asp Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  65
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  65

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  66
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  66

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Gly Asp  
    1370 


<210>  67
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  67

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  68
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  68

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Val Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  69
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  69

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Arg Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  70
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  70

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Ser Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Tyr Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Val 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Gln Leu Leu Asp Phe Leu Ala Lys Glu Phe Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Ile Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Arg Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ser Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asp Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Pro Asp Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Lys Val Asp Asp Asn Asn Lys Pro Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Glu 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Glu Thr Gly 
    1055                 1060                 1065             


Glu Ile  Ala Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Ser Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Leu Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Lys Glu Leu Ile  Gly Ile Thr Ile Met  Glu Arg Glu 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Thr Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Ile Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Ser Asp Asn Lys Asp  Asn Thr Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Lys Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ser Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asp Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  71
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  71

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Arg Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln His Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Leu Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Ala Gly Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Ser Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Asp Glu 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Val Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  72
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  72

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Arg Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Leu Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Glu Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Ala Gly Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Leu Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Ser Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Asp Glu 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Thr Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Gly  
    1370 


<210>  73
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  73

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Arg Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Leu Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Ala Gly Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Leu Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Ser Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Asp Glu 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Thr Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Gly  
    1370 


<210>  74
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  74

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Arg Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Leu Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Ala Gly Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Leu Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Asp Glu 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Val Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Asp Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  75
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  75

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Arg Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Leu Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Ala Gly Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Ser Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Asp Glu 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Val Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  76
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  76

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Arg Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Leu Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Ala Gly Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Ser Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Asp Glu 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Val Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Lys Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Lys Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  77
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  77

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Arg Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Leu Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Leu Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Ala Gly Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Ser Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Asp Glu 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Val Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asp  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  78
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae


<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  Xaa can be any naturally occurring amino acid

<400>  78

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Xaa Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  79
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  79

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ser Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  80
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  80

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ser Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Cys Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Asp Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asn Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Arg Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Ile Asp 
        195                 200                 205             


Val Glu Gly Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Thr Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Gly Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Leu Val Asp Lys Glu Ala Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Pro Ile Ile Asp Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Val Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Thr Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Glu Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Phe 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  81
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  81

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ser Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Asp Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Arg Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Ile Asp 
        195                 200                 205             


Val Glu Gly Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Thr Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Gly Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Leu Val Asp Lys Glu Ala Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Pro Ile Ile Asp Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Val Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Thr Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Glu Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Phe 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  82
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  82

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ser Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Asp Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Arg Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Ile Asp 
        195                 200                 205             


Val Glu Gly Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Thr Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Gly Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Leu Val Asp Lys Glu Ala Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Pro Ile Ile Asp Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Val Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Thr Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Glu Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Thr 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Arg Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Phe 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  83
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  83

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ser Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Asp Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asn Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Arg Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Ile Asp 
        195                 200                 205             


Val Glu Gly Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Thr Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Gly Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Leu Val Asp Lys Glu Ala Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Pro Ile Ile Asp Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Val Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Thr Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Glu Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Phe 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Phe 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  84
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  84

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ser Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Asp Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asn Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Arg Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Ile Asp 
        195                 200                 205             


Val Glu Gly Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Thr Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Gly Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Leu Val Asp Lys Glu Ala Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Pro Ile Ile Asp Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Val Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Thr Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Glu Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Phe 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  85
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  85

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Ser Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Val 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Gln Leu Leu Asp Phe Leu Ala Lys Glu Phe Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Ile Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Arg Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ser Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asp Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Pro Asp Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Lys Val Asp Asp Asn Asn Lys Pro Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Glu 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Glu Thr Gly 
    1055                 1060                 1065             


Glu Ile  Ala Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Ser Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Leu Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Lys Glu Leu Ile  Gly Ile Thr Ile Met  Glu Arg Glu 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Thr Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Ser Asp Asn Lys Asp  Asn Thr Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Lys Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ser Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asp Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  86
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  86

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Arg Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Leu Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Ala Gly Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Leu Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Asp Glu 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp Leu Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Val Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Asp Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  87
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  87

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ser Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Asp Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Phe Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Arg Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Ile Asp 
        195                 200                 205             


Ile Glu Gly Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Thr Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Gly Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Leu Val Asp Lys Glu Ala Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Lys Ser Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Lys Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  88
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  88

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ser Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Asp Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Phe Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Arg Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Ile Asp 
        195                 200                 205             


Val Glu Gly Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Thr Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Gly Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Leu Val Asp Lys Glu Ala Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Lys Ser Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Lys Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  89
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  89

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  90
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  90

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ser Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Asp Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Arg Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Ile Asp 
        195                 200                 205             


Val Glu Gly Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Ala Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Thr Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Gly Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Leu Val Asp Lys Glu Ala Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Pro Ile Ile Asp Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Val Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Thr Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Glu Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Phe 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  91
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  91

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Ala Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  92
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  92

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Ser Leu Ser Asp 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  93
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  93

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Ile Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  94
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  94

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Val Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  95
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  95

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Leu Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Gly Asp  
    1370 


<210>  96
<211>  1384
<212>  PRT
<213>  Streptococcus agalactiae

<400>  96

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Arg 
    690                 695                 700                 


Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
705                 710                 715                 720 


Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp Asn Leu 
                725                 730                 735     


Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr 
    770                 775                 780                 


Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu Leu Asp 
785                 790                 795                 800 


Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile Leu Lys 
                805                 810                 815     


Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu Phe Leu 
            820                 825                 830         


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala Leu Asp 
        835                 840                 845             


Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala 
    850                 855                 860                 


Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser Ser Ala 
865                 870                 875                 880 


Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile Val Lys 
                885                 890                 895     


Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu Met Ser 
            900                 905                 910         


Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
        915                 920                 925             


Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu Thr Arg 
    930                 935                 940                 


Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Asn 
945                 950                 955                 960 


Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile Val Thr 
                965                 970                 975     


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly Phe Tyr 
            980                 985                 990         


Lys Ile Arg Glu Val Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
        995                 1000                 1005             


Asn Ala  Val Val Ala Lys Ala  Ile Leu Thr Lys Tyr  Pro Gln Leu 
    1010                 1015                 1020             


Glu Pro  Glu Phe Val Tyr Gly  Asp Tyr Pro Lys Tyr  Asn Ser Tyr 
    1025                 1030                 1035             


Lys Thr  Arg Lys Ser Ala Thr  Glu Lys Leu Phe Phe  Tyr Ser Asn 
    1040                 1045                 1050             


Ile Met  Asn Phe Phe Lys Thr  Lys Val Thr Leu Ala  Asp Gly Thr 
    1055                 1060                 1065             


Val Val  Val Lys Asp Asp Ile  Glu Val Asn Asn Asp  Thr Gly Glu 
    1070                 1075                 1080             


Ile Val  Trp Asp Lys Lys Lys  His Phe Ala Thr Val  Arg Lys Val 
    1085                 1090                 1095             


Leu Ser  Tyr Pro Gln Asn Asn  Ile Val Lys Lys Thr  Glu Ile Gln 
    1100                 1105                 1110             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Ala His  Gly Asn Ser 
    1115                 1120                 1125             


Asp Lys  Leu Ile Pro Arg Lys  Thr Lys Asp Ile Tyr  Leu Asp Pro 
    1130                 1135                 1140             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Ile Val Ala  Tyr Ser Val 
    1145                 1150                 1155             


Leu Val  Val Ala Asp Ile Lys  Lys Gly Lys Ala Gln  Lys Leu Lys 
    1160                 1165                 1170             


Thr Val  Thr Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Arg 
    1175                 1180                 1185             


Phe Glu  Lys Asn Pro Ser Ala  Phe Leu Glu Ser Lys  Gly Tyr Leu 
    1190                 1195                 1200             


Asn Ile  Arg Ala Asp Lys Leu  Ile Ile Leu Pro Lys  Tyr Ser Leu 
    1205                 1210                 1215             


Phe Glu  Leu Glu Asn Gly Arg  Arg Arg Leu Leu Ala  Ser Ala Gly 
    1220                 1225                 1230             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Thr  Gln Phe Met 
    1235                 1240                 1245             


Lys Phe  Leu Tyr Leu Ala Ser  Arg Tyr Asn Glu Ser  Lys Gly Lys 
    1250                 1255                 1260             


Pro Glu  Glu Ile Glu Lys Lys  Gln Glu Phe Val Asn  Gln His Val 
    1265                 1270                 1275             


Ser Tyr  Phe Asp Asp Ile Leu  Gln Leu Ile Asn Asp  Phe Ser Lys 
    1280                 1285                 1290             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Glu Lys Ile  Asn Lys Leu 
    1295                 1300                 1305             


Tyr Gln  Asp Asn Lys Glu Asn  Ile Ser Val Asp Glu  Leu Ala Asn 
    1310                 1315                 1320             


Asn Ile  Ile Asn Leu Phe Thr  Phe Thr Ser Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Phe Phe Asp Lys  Ile Val Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asn  Ser Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Gly Lys  Leu Gly Glu 
    1370                 1375                 1380             


Asp 
    


<210>  97
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  97

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ser Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Asp Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asn Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Arg Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Ile Asp 
        195                 200                 205             


Val Glu Gly Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Thr Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Gly Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Leu Val Asp Lys Glu Ala Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Pro Ile Ile Asp Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Val Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Lys Gly Arg Arg Asn Thr Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Glu Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Phe 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  98
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  98

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Arg Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  99
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  99

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Arg Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Leu Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Ala Gly Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Ser Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Asp Glu 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Val Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Lys Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  100
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  100

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Ile Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  101
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  101

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Ser Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  102
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  102

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ser Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Asp Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asn Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Arg Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Ile Asp 
        195                 200                 205             


Val Glu Gly Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Thr Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Ser Lys Thr 
        355                 360                 365             


Asn Gln Gly Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Leu Val Asp Lys Glu Ala Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Pro Ile Ile Asp Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Val Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Thr Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Glu Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Phe 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  103
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  103

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Leu Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Ile Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  104
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  104

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Asp Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  105
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  105

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Ser Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Val 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Gln Leu Leu Asp Phe Leu Ala Lys Glu Phe Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Ile Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Arg Glu Ser Gln Lys Ile Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ser Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asp Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Ser Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Pro Asp Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Lys Val Asp Asp Asn Asn Lys Pro Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Glu 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Glu Thr Gly 
    1055                 1060                 1065             


Glu Ile  Ala Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Ser Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Leu Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Lys Glu Leu Ile  Gly Ile Thr Ile Met  Glu Arg Glu 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Thr Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Ser Asp Asn Lys Asp  Asn Thr Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Lys Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ser Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asp Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  106
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  106

Met Asn Lys Pro Tyr Ser Ile Gly Xaa Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  107
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae

<400>  107

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Ile Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Lys Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asp Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Leu Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Leu Val Asp Lys Glu Ala Ser Ala Glu Ala Phe Ile His Cys Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu Tyr Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Gln Leu Leu Asp Phe Leu Ala Lys Glu Phe Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Gly Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Asp Ile 
625                 630                 635                 640 


Tyr Lys Asp Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asn Lys Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Ser Ala Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Ala Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ser Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Ser Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Lys Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Arg Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Glu Lys Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Thr Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  108
<211>  1386
<212>  PRT
<213>  Streptococcus anginosus

<400>  108

Met Asn Gln Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Met Gln Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Asp Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Ile Ala Ala Glu Val Lys Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ile Ser Gln Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asn Val Gln Ala Leu Phe Lys Asp Phe Val Glu Val Tyr 
            180                 185                 190         


Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala His Tyr Pro Ala Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Phe Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Leu Leu Gly Glu Val Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Phe Glu 
                325                 330                 335     


Asp Phe Ile Lys Val Asn Ala Leu Asp Gln Tyr Asn Ala Ile Phe Lys 
            340                 345                 350         


Asp Lys Asn Lys Lys Gly Tyr Ala Gly Tyr Ile Glu Ser Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Gln Ile Asn 
    370                 375                 380                 


Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp 
465                 470                 475                 480 


Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Val Asn Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ser Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asn Lys Ser Phe Leu 
        595                 600                 605             


Asp Asn Lys Glu Asn Ala Gln Ile Ile Glu Asp Ile Ile Gln Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Lys Ala Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Ile Ile Gly Asp Val Asp Asp 
705                 710                 715                 720 


Ile Ala Asn Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly His Asn Pro Ala Asn Ile Ile Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Asp Arg Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Asn Leu Asp Asn Pro Val Asn Ile Lys Asn Val 
785                 790                 795                 800 


Glu Asn Gln Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu 
            820                 825                 830         


Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Tyr Ile Lys Asp 
        835                 840                 845             


Asp Ser Phe Asp Asn Arg Val Leu Thr Ser Ser Ser Glu Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Ile Glu Val Val Cys Ala Arg Lys Ala 
865                 870                 875                 880 


Asp Trp Met Arg Leu Arg Lys Ala Gly Leu Ile Ser Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Asn Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Val Leu Asp Ala Arg Phe Asn Ala Lys His Asp Glu 
    930                 935                 940                 


Asn Lys Lys Val Ile Arg Asp Val Lys Ile Ile Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Gln Phe Arg Lys Asp Phe Lys Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Ile 
            980                 985                 990         


Gly Thr Ala Leu Leu Lys Lys Tyr  Pro Lys Leu Ala Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Glu Phe Lys Lys Tyr  Asp Val Arg Lys Phe  Ile Ala Lys 
    1010                 1015                 1020             


Ser Asp  Lys Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Leu Met Asn Phe Phe  Lys Lys Glu Val Lys  Phe Ala Asp 
    1040                 1045                 1050             


Gly Thr  Val Val Glu Arg Pro  Asp Ile Glu Thr Ser  Glu Asp Gly 
    1055                 1060                 1065             


Glu Ile  Ala Trp Asn Lys Gln  Thr Asp Phe Lys Ile  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1085                 1090                 1095             


Gln Thr  His Gly Leu Asp Arg  Gly Lys Pro Arg Gly  Leu Phe Asn 
    1100                 1105                 1110             


Ala Asn  Pro Ser Pro Lys Pro  Lys Pro Asp Ser Ser  Glu Asn Leu 
    1115                 1120                 1125             


Val Gly  Val Lys Arg Asn Leu  Asp Pro Lys Lys Tyr  Gly Gly Tyr 
    1130                 1135                 1140             


Ala Gly  Ile Ser Asn Ser Tyr  Ala Val Leu Val Lys  Ala Ile Ile 
    1145                 1150                 1155             


Glu Lys  Gly Val Lys Lys Lys  Glu Thr Met Val Leu  Glu Phe Gln 
    1160                 1165                 1170             


Gly Ile  Ser Ile Leu Asp Arg  Ile Thr Phe Glu Lys  Asp Lys Arg 
    1175                 1180                 1185             


Ala Phe  Leu Leu Gly Lys Gly  Tyr Lys Asp Ile Lys  Lys Ile Ile 
    1190                 1195                 1200             


Glu Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Lys Asp  Gly Ser Arg 
    1205                 1210                 1215             


Arg Met  Leu Ala Ser Ile Leu  Ser Thr Asn Asn Lys  Arg Gly Glu 
    1220                 1225                 1230             


Ile His  Lys Gly Asn Glu Leu  Phe Val Pro Gln Lys  Phe Thr Thr 
    1235                 1240                 1245             


Leu Leu  Tyr His Ala Lys Arg  Ile Asn Asn Pro Ile  Asn Lys Asp 
    1250                 1255                 1260             


His Ile  Glu Tyr Val Lys Lys  His Arg Asp Asp Phe  Lys Glu Leu 
    1265                 1270                 1275             


Leu Asn  Tyr Val Leu Glu Phe  Asn Glu Lys Tyr Val  Gly Ala Thr 
    1280                 1285                 1290             


Lys Asn  Gly Glu Arg Leu Lys  Glu Ala Val Ala Asp  Phe Asp Ser 
    1295                 1300                 1305             


Lys Ser  Asn Glu Glu Ile Cys  Thr Ser Phe Leu Gly  Ala Val Asn 
    1310                 1315                 1320             


Ser Lys  Asn Ala Gly Leu Phe  Glu Leu Thr Ser Leu  Gly Ser Ala 
    1325                 1330                 1335             


Ser Asp  Phe Glu Phe Leu Gly  Val Lys Ile Pro Arg  Tyr Arg Asp 
    1340                 1345                 1350             


Tyr Thr  Pro Ser Ser Leu Leu  Lys Asp Ser Thr Leu  Ile His Gln 
    1355                 1360                 1365             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1370                 1375                 1380             


Gly Glu  Asp 
    1385     


<210>  109
<211>  1346
<212>  PRT
<213>  Streptococcus anginosus

<400>  109

Met Met Lys Lys Glu Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Thr Glu Glu Met Asn Lys Val Asp Glu 
                85                  90                  95      


Asn Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Glu Glu Asp Lys 
            100                 105                 110         


Gln Gly Ser Lys Tyr Pro Ile Phe Gly Thr Leu Lys Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Lys Phe Lys Thr Ile Tyr His Leu Arg Glu Glu Leu Ala 
    130                 135                 140                 


Asn Ser Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Phe Arg Gly His Phe Leu Tyr Glu Gly Asp Leu Lys 
                165                 170                 175     


Ala Glu Asn Thr Asp Val Gln Ala Leu Phe Lys Asp Phe Val Glu Glu 
            180                 185                 190         


Tyr Asp Lys Thr Ile Glu Glu Ser His Leu Ser Glu Ile Thr Val Asp 
        195                 200                 205             


Ala Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Ser Arg Leu Glu 
    210                 215                 220                 


Asn Leu Ile Ala His Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn 
                245                 250                 255     


Phe Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Glu Leu Leu Gly Glu Ile Gly Asp Glu Tyr Ala 
        275                 280                 285             


Asp Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Ala Val Asp Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Val Lys Arg Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Leu 
                325                 330                 335     


Lys Asp Phe Ile Lys Val Asn Ala Pro Asp Gln Tyr Asn Ala Ile Phe 
            340                 345                 350         


Lys Asp Lys Asn Lys Lys Gly Tyr Ala Gly Tyr Ile Glu Ser Gly Val 
        355                 360                 365             


Glu Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Lys Ile 
    370                 375                 380                 


Asn Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp Cys Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala 
    450                 455                 460                 


Trp Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp 
465                 470                 475                 480 


Asp Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met 
                485                 490                 495     


Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Pro Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe Phe Asp Thr Asn Met 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr 
545                 550                 555                 560 


Lys Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asn Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ser 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe 
        595                 600                 605             


Leu Asp Asp Lys Ala Asn Glu Lys Thr Ile Glu Asp Ile Ile Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys 
625                 630                 635                 640 


Tyr Ser Asp Ile Phe Thr Lys Ala Gln Leu Lys Lys Leu Glu Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu 
    690                 695                 700                 


Ser Phe Lys Glu Glu Ile Ala Arg Ala Gln Ile Ile Gly Asp Val Asp 
705                 710                 715                 720 


Asp Ile Ala Asn Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly His Asn Pro Ala Asn Ile Ile Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asp Lys Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Leu 
    770                 775                 780                 


Leu Gln Asp Ser Leu Lys Asn Leu Asp Asn Pro Val Asn Ile Lys Asn 
785                 790                 795                 800 


Val Glu Asn Gln Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Ile 
                805                 810                 815     


Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Thr Leu Asp Ile Asn Asn 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Leu Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Ile Glu Val Val His Glu Met Lys 
865                 870                 875                 880 


Ser Phe Trp Ser Lys Leu Leu Ser Val Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Glu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Glu Arg Phe Asn Thr Glu Phe Asp 
    930                 935                 940                 


Gly Ala Gln Arg Arg Ile Arg Asn Val Lys Ile Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Asn Ala Leu Leu Leu Lys  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Glu Tyr Pro Lys  Tyr Asn Ser Tyr Arg  Ser Arg Lys 
    1010                 1015                 1020             


Ser Ala  Thr Glu Lys Phe Leu  Phe Tyr Ser Asn Ile  Leu Arg Phe 
    1025                 1030                 1035             


Phe Lys  Lys Glu Asp Ile Gln  Thr Asn Glu Asp Gly  Glu Ile Ala 
    1040                 1045                 1050             


Trp Asn  Lys Glu Lys His Ile  Lys Ile Leu Arg Lys  Val Leu Ser 
    1055                 1060                 1065             


Tyr Pro  Gln Val Asn Ile Val  Lys Lys Thr Glu Glu  Gln Thr Gly 
    1070                 1075                 1080             


Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys Gly Glu  Ser Asp Lys 
    1085                 1090                 1095             


Leu Ile  Pro Arg Lys Thr Lys  Asn Ser Tyr Trp Asn  Pro Lys Lys 
    1100                 1105                 1110             


Tyr Gly  Gly Phe Asp Ser Pro  Val Val Ala Tyr Ser  Ile Leu Val 
    1115                 1120                 1125             


Phe Ala  Asp Val Glu Lys Gly  Lys Ser Lys Lys Leu  Arg Lys Val 
    1130                 1135                 1140             


Gln Asp  Met Val Gly Ile Thr  Ile Met Glu Lys Lys  Arg Phe Glu 
    1145                 1150                 1155             


Lys Asn  Pro Val Asp Phe Leu  Glu Gln Arg Gly Tyr  Arg Asn Val 
    1160                 1165                 1170             


Arg Leu  Glu Lys Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1175                 1180                 1185             


Leu Glu  Asn Lys Arg Arg Arg  Leu Leu Ala Ser Ala  Arg Glu Leu 
    1190                 1195                 1200             


Gln Lys  Gly Asn Glu Leu Val  Ile Pro Gln Arg Phe  Thr Thr Leu 
    1205                 1210                 1215             


Leu Tyr  His Ser Tyr Gln Ile  Glu Lys Asn Tyr Glu  Pro Glu His 
    1220                 1225                 1230             


Arg Glu  Tyr Val Glu Lys His  Lys Asp Glu Phe Lys  Glu Leu Leu 
    1235                 1240                 1245             


Glu Tyr  Ile Ser Val Phe Ser  Arg Lys Tyr Val Leu  Ala Asp Asn 
    1250                 1255                 1260             


Asn Leu  Thr Lys Ile Glu Met  Leu Phe Ser Lys Asn  Lys Asp Ala 
    1265                 1270                 1275             


Glu Val  Ser Ser Leu Ala Lys  Ser Phe Ile Ser Leu  Leu Thr Phe 
    1280                 1285                 1290             


Thr Ala  Phe Gly Ala Pro Ala  Ala Phe Asn Phe Phe  Gly Glu Asn 
    1295                 1300                 1305             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Val Thr Glu Cys  Leu Asn Ala 
    1310                 1315                 1320             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1325                 1330                 1335             


Asp Leu  Ser Lys Leu Gly Glu  Asp 
    1340                 1345     


<210>  110
<211>  1346
<212>  PRT
<213>  Streptococcus anginosus

<400>  110

Met Met Lys Lys Glu Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Met Gln Val Asp Glu 
                85                  90                  95      


Ser Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Glu Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Arg Tyr Pro Ile Phe Gly Asn Ile Ala Ala Glu Val Lys 
        115                 120                 125             


Tyr His Asp Asp Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Val 
    130                 135                 140                 


Asp Ile Ser Gln Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys 
                165                 170                 175     


Ala Glu Asn Thr Asn Val Gln Ala Leu Phe Lys Asp Phe Val Glu Val 
            180                 185                 190         


Tyr Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Met Thr Val Asp 
        195                 200                 205             


Ala Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Leu Val Glu Cys Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn 
                245                 250                 255     


Phe Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Gly Leu Leu Gly Glu Ile Gly Asp Glu Tyr Ala 
        275                 280                 285             


Asp Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Ala Val Asp Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Val Lys Arg Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Leu 
                325                 330                 335     


Lys Asp Phe Ile Lys Val Asn Ala Pro Ala Gln Tyr Asp Asp Ile Phe 
            340                 345                 350         


Lys Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val 
        355                 360                 365             


Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile 
    370                 375                 380                 


Asp Gly Ser Asp Tyr Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala 
    450                 455                 460                 


Trp Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp 
465                 470                 475                 480 


Asp Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met 
                485                 490                 495     


Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Pro Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe Phe Asp Thr Asn Met 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr 
545                 550                 555                 560 


Lys Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asn Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe 
        595                 600                 605             


Leu Asp Asp Lys Val Asn Glu Lys Ile Ile Glu Asp Ile Ile Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys 
625                 630                 635                 640 


Tyr Ser Asp Ile Phe Thr Thr Gln Gln Leu Lys Lys Leu Glu Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu 
    690                 695                 700                 


Ser Phe Lys Glu Glu Ile Ala Arg Ala Gln Ile Ile Gly Asp Val Asp 
705                 710                 715                 720 


Asp Ile Ala Asn Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly His Asn Pro Ala Asn Ile Ile Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asp Lys Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Leu 
    770                 775                 780                 


Leu Gln Asp Ser Leu Lys Asn Leu Asp Asn Pro Val Asn Ile Lys Asn 
785                 790                 795                 800 


Val Glu Asn Gln Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Ile 
                805                 810                 815     


Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Thr Leu Asp Ile Asn Asn 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Leu Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Ile Glu Val Val His Glu Met Lys 
865                 870                 875                 880 


Ser Phe Trp Ser Lys Leu Leu Ser Val Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Glu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Glu Arg Phe Asn Thr Glu Phe Asp 
    930                 935                 940                 


Gly Ala Gln Arg Arg Ile Arg Asn Val Lys Ile Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Asn Ala Leu Leu Leu Lys  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Glu Tyr Pro Lys  Tyr Asn Ser Tyr Arg  Ser Arg Lys 
    1010                 1015                 1020             


Ser Ala  Thr Glu Lys Phe Leu  Phe Tyr Ser Asn Ile  Leu Arg Phe 
    1025                 1030                 1035             


Phe Lys  Lys Glu Asp Ile Gln  Thr Asn Glu Asp Gly  Glu Ile Ala 
    1040                 1045                 1050             


Trp Asn  Lys Glu Lys His Ile  Lys Ile Leu Arg Lys  Val Leu Ser 
    1055                 1060                 1065             


Tyr Pro  Gln Val Asn Ile Val  Lys Lys Thr Glu Glu  Gln Thr Gly 
    1070                 1075                 1080             


Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys Gly Glu  Ser Asp Lys 
    1085                 1090                 1095             


Leu Ile  Pro Arg Lys Thr Lys  Asn Ser Tyr Trp Asn  Pro Lys Lys 
    1100                 1105                 1110             


Tyr Gly  Gly Phe Asp Ser Pro  Val Val Ala Tyr Ser  Ile Leu Val 
    1115                 1120                 1125             


Phe Ala  Asp Val Glu Lys Gly  Lys Ser Lys Lys Leu  Arg Lys Val 
    1130                 1135                 1140             


Gln Asp  Met Val Gly Ile Thr  Ile Met Glu Lys Lys  Arg Phe Glu 
    1145                 1150                 1155             


Lys His  Pro Val Asp Phe Leu  Glu Gln Arg Gly Tyr  Arg Asn Val 
    1160                 1165                 1170             


Arg Leu  Glu Lys Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1175                 1180                 1185             


Leu Glu  Asn Lys Arg Arg Arg  Leu Leu Ala Ser Ala  Arg Glu Leu 
    1190                 1195                 1200             


Gln Lys  Gly Asn Glu Leu Val  Ile Pro Gln Arg Phe  Thr Thr Leu 
    1205                 1210                 1215             


Leu Tyr  His Ser Tyr Arg Ile  Glu Lys Asp Tyr Glu  Pro Glu His 
    1220                 1225                 1230             


Arg Glu  Tyr Val Glu Lys His  Lys Asp Glu Phe Lys  Glu Leu Leu 
    1235                 1240                 1245             


Glu Tyr  Ile Ser Val Phe Ser  Arg Lys Tyr Val Leu  Ala Asp Asn 
    1250                 1255                 1260             


Asn Leu  Thr Lys Ile Glu Met  Leu Phe Ser Lys Asn  Lys Asp Ala 
    1265                 1270                 1275             


Glu Val  Ser Ser Leu Ala Lys  Ser Phe Ile Ser Leu  Leu Thr Phe 
    1280                 1285                 1290             


Thr Ala  Phe Gly Ala Pro Ala  Ala Phe Asn Phe Phe  Gly Glu Asn 
    1295                 1300                 1305             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Val Thr Glu Cys  Leu Asn Ala 
    1310                 1315                 1320             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1325                 1330                 1335             


Asp Leu  Ser Lys Leu Gly Glu  Asp 
    1340                 1345     


<210>  111
<211>  1345
<212>  PRT
<213>  Streptococcus anginosus

<400>  111

Met Lys Lys Glu Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Thr Glu Glu Met Asn Lys Val Asp Glu Asn 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Glu Glu Asp Lys Gln 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Gly Thr Leu Lys Glu Glu Lys Glu Tyr 
        115                 120                 125             


His Lys Lys Phe Lys Thr Ile Tyr His Leu Arg Glu Glu Leu Ala Asn 
    130                 135                 140                 


Ser Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Tyr Glu Gly Asp Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Ala Leu Phe Lys Asp Phe Val Glu Glu Tyr 
            180                 185                 190         


Asp Lys Thr Ile Glu Glu Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Ser Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala His Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Glu Ile Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Ala Val Asp Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Leu Lys 
                325                 330                 335     


Asp Phe Ile Lys Val Asn Ala Pro Asp Gln Tyr Asn Ala Ile Phe Lys 
            340                 345                 350         


Asp Lys Asn Lys Lys Gly Tyr Ala Gly Tyr Ile Glu Ser Gly Val Glu 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Lys Ile Asn 
    370                 375                 380                 


Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp Cys Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp 
465                 470                 475                 480 


Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe Phe Asp Thr Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Val Asn Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ser Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asp Lys Ala Asn Glu Lys Thr Ile Glu Asp Ile Ile Gln Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Lys Ala Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Arg Ala Gln Ile Ile Gly Asp Val Asp Asp 
705                 710                 715                 720 


Ile Ala Asn Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly His Asn Pro Ala Asn Ile Ile Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Asp Lys Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Asn Leu Asp Asn Pro Val Asn Ile Lys Asn Val 
785                 790                 795                 800 


Glu Asn Gln Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu 
            820                 825                 830         


Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp 
        835                 840                 845             


Asn Ser Leu Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Ile Glu Val Val His Glu Met Lys Ser 
865                 870                 875                 880 


Phe Trp Ser Lys Leu Leu Ser Val Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Glu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Glu Arg Phe Asn Thr Glu Phe Asp Gly 
    930                 935                 940                 


Ala Gln Arg Arg Ile Arg Asn Val Lys Ile Ile Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Asn Ala Leu Leu Leu Lys Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Glu Tyr Pro Lys Tyr  Asn Ser Tyr Arg Ser  Arg Lys Ser 
    1010                 1015                 1020             


Ala Thr  Glu Lys Phe Leu Phe  Tyr Ser Asn Ile Leu  Arg Phe Phe 
    1025                 1030                 1035             


Lys Lys  Glu Asp Ile Gln Thr  Asn Glu Asp Gly Glu  Ile Ala Trp 
    1040                 1045                 1050             


Asn Lys  Glu Lys His Ile Lys  Ile Leu Arg Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Glu Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Asn  Ser Tyr Trp Asn Pro  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Val  Val Ala Tyr Ser Ile  Leu Val Phe 
    1115                 1120                 1125             


Ala Asp  Val Glu Lys Gly Lys  Ser Lys Lys Leu Arg  Lys Val Gln 
    1130                 1135                 1140             


Asp Met  Val Gly Ile Thr Ile  Met Glu Lys Lys Arg  Phe Glu Lys 
    1145                 1150                 1155             


Asn Pro  Val Asp Phe Leu Glu  Gln Arg Gly Tyr Arg  Asn Val Arg 
    1160                 1165                 1170             


Leu Glu  Lys Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1175                 1180                 1185             


Glu Asn  Lys Arg Arg Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Leu Val Ile  Pro Gln Arg Phe Thr  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ser Tyr Gln Ile Glu  Lys Asn Tyr Glu Pro  Glu His Arg 
    1220                 1225                 1230             


Glu Tyr  Val Glu Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Glu 
    1235                 1240                 1245             


Tyr Ile  Ser Val Phe Ser Arg  Lys Tyr Val Leu Ala  Asp Asn Asn 
    1250                 1255                 1260             


Leu Thr  Lys Ile Glu Met Leu  Phe Ser Lys Asn Lys  Asp Ala Glu 
    1265                 1270                 1275             


Val Ser  Ser Leu Ala Lys Ser  Phe Ile Ser Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Phe  Gly Ala Pro Ala Ala  Phe Asn Phe Phe Gly  Glu Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Val Thr Glu Cys Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Glu Asp  
    1340                 1345 


<210>  112
<211>  1377
<212>  PRT
<213>  Streptococcus caballi

<400>  112

Met Thr Lys Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Asp Ile Phe Thr Glu Glu Met Ala Lys Val Asp Asp 
                85                  90                  95      


Ser Phe Phe Gln Arg Leu Asp Glu Ser Phe Leu Thr Asp Asn Asp Lys 
            100                 105                 110         


Asn Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala 
        115                 120                 125             


Tyr His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn 
                165                 170                 175     


Ala Glu Asn Thr Asp Val Gln Lys Leu Phe Thr Asp Phe Val Gly Val 
            180                 185                 190         


Tyr Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp 
        195                 200                 205             


Ala Ala Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn 
                245                 250                 255     


Phe Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala 
        275                 280                 285             


Asp Leu Phe Thr Ser Ser Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Lys Arg Tyr Val Glu His His Glu Asp Leu Glu Lys Leu 
                325                 330                 335     


Lys Glu Phe Ile Lys Ala Asn Lys Ser Glu Leu Tyr His Asp Ile Phe 
            340                 345                 350         


Lys Asp Lys Thr Gln Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val 
        355                 360                 365             


Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Thr Lys Ile 
    370                 375                 380                 


Asn Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Glu Glu Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asp Ser Arg Phe Ala 
    450                 455                 460                 


Trp Ala Glu Tyr Arg Ser Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp 
465                 470                 475                 480 


Lys Val Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met 
                485                 490                 495     


Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser His Val Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Tyr Val Asn Glu Gln Gly Lys Asp Ser Phe Phe Asp Ser Asn Met 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr 
545                 550                 555                 560 


Lys Glu Lys Leu Leu Asn Tyr Leu Asp Lys Glu Phe Pro Glu Tyr Arg 
                565                 570                 575     


Ile Gln Asp Leu Val Gly Leu Asp Lys Glu Asn Lys Ser Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ser Phe 
        595                 600                 605             


Leu Asp Asp Lys Val Asn Glu Glu Val Ile Glu Asp Ile Ile Lys Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Gln Gln Arg Leu Gln Lys 
625                 630                 635                 640 


Tyr Ser Asp Ile Phe Thr Lys Gln Gln Leu Lys Lys Leu Glu Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Ser Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu 
    690                 695                 700                 


Ser Phe Lys Gln Ile Ile Gln Glu Ala Gln Val Val Gly Asp Val Asp 
705                 710                 715                 720 


Asp Ile Glu Thr Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Ile Lys Val 
            740                 745                 750         


Met Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Arg Gly Arg Ser Gln Ser Gln Gln Arg Leu Lys Lys 
    770                 775                 780                 


Leu Gln Asn Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn Glu Glu 
785                 790                 795                 800 


Lys Pro Ser Tyr Ile Glu Asp Lys Val Glu Asn Ser His Leu Gln Asn 
                805                 810                 815     


Asp Gln Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr 
            820                 825                 830         


Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val 
    850                 855                 860                 


Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser 
865                 870                 875                 880 


Leu Gly Ile Val Arg Ala Arg Lys Ala Glu Trp Val Arg Leu Tyr Lys 
                885                 890                 895     


Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ala Arg Phe Asn Thr Glu Arg Asp Glu Asn Asp Lys Val Ile Arg Asp 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys 
                965                 970                 975     


Glu Phe Lys Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Lys Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Lys Lys 
    1010                 1015                 1020             


Tyr Asp  Val Arg Lys Leu Val  Ala Lys Ser Ser Asp  Asp His Ser 
    1025                 1030                 1035             


Glu Met  Gly Lys Ala Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Leu 
    1040                 1045                 1050             


Met Asn  Phe Phe Lys Arg Val  Ile Arg Tyr Ser Asn  Gly Lys Val 
    1055                 1060                 1065             


Ile Val  Arg Pro Val Val Glu  Tyr Ser Lys Asp Thr  Gly Glu Ile 
    1070                 1075                 1080             


Ala Trp  Asn Lys Arg Thr Asp  Phe Glu Lys Val Arg  Lys Val Leu 
    1085                 1090                 1095             


Ser Tyr  Pro Gln Val Asn Ile  Val Lys Lys Val Glu  Thr Gln Thr 
    1100                 1105                 1110             


Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro Lys Gly  Asp Ser Asp 
    1115                 1120                 1125             


Lys Leu  Ile Pro Arg Lys Thr  Lys Lys Val Leu Trp  Glu Pro Lys 
    1130                 1135                 1140             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1145                 1150                 1155             


Val Val  Ala Asp Val Glu Lys  Gly Lys Thr Lys Lys  Leu Lys Thr 
    1160                 1165                 1170             


Val Lys  Glu Leu Val Gly Ile  Ser Ile Met Glu Arg  Ser Phe Phe 
    1175                 1180                 1185             


Glu Lys  Asn Pro Val Glu Phe  Leu Lys Asn Lys Gly  Tyr Gln Asn 
    1190                 1195                 1200             


Val Gln  Glu Asp Lys Leu Met  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1205                 1210                 1215             


Glu Phe  Glu Gly Gly Arg Arg  Arg Leu Leu Ala Ser  Ala Thr Glu 
    1220                 1225                 1230             


Leu Gln  Lys Gly Asn Glu Ile  Met Leu Ser Ala His  Leu Val Ala 
    1235                 1240                 1245             


Leu Leu  Tyr His Ala His Arg  Ile Gly Asn Phe Asn  Ser Ala Glu 
    1250                 1255                 1260             


His Leu  Lys Tyr Val Ser Glu  His Lys Lys Glu Phe  Glu Glu Val 
    1265                 1270                 1275             


Leu Ser  Cys Val Glu Asn Phe  Ala Asn Val Tyr Val  Asp Val Glu 
    1280                 1285                 1290             


Lys Asn  Leu Ser Lys Ile Arg  Ala Ala Ala Asp Ser  Met Asp Asn 
    1295                 1300                 1305             


Phe Ser  Ile Glu Glu Ile Ser  Asp Ser Phe Ile Asn  Leu Leu Thr 
    1310                 1315                 1320             


Leu Thr  Ala Leu Gly Ala Pro  Ala Asp Phe Asn Phe  Leu Gly Glu 
    1325                 1330                 1335             


Lys Ile  Pro Arg Lys Arg Tyr  Asn Ser Thr Lys Glu  Cys Leu Asn 
    1340                 1345                 1350             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Ser Lys Leu Gly  Glu Glu 
    1370                 1375         


<210>  113
<211>  1375
<212>  PRT
<213>  Streptococcus canis

<400>  113

Met Glu Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asn Arg Lys Ser Ile Lys Lys Asn Leu Met 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Asn Glu Met Ala Lys Leu Asp Asp Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


Asn Glu Arg His Pro Ile Phe Gly Asn Leu Ala Asp Glu Val Ala Tyr 
        115                 120                 125             


His Arg Asn Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Pro Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asn Ala 
                165                 170                 175     


Glu Asn Ser Asp Val Ala Lys Leu Phe Tyr Gln Leu Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Ser Pro Leu Asp Glu Ile Glu Val Asp Ala 
        195                 200                 205             


Lys Gly Ile Leu Ser Ala Arg Leu Ser Lys Ser Lys Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Ala Val Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Ile Ile Ala Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Thr Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Glu Leu Leu Gly Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ser Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Ser Asn Ser Glu Val Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Asp Glu His His Gln Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Thr Leu Val Arg Gln Gln Phe Pro Glu Lys Tyr Ala Glu Ile Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ile Gly Ile Lys 
        355                 360                 365             


His Arg Lys Arg Thr Thr Lys Leu Ala Thr Gln Glu Glu Phe Tyr Lys 
    370                 375                 380                 


Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Ala Glu Glu Leu Leu 
385                 390                 395                 400 


Ala Lys Leu Asn Arg Asp Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Ser Ile Pro His Gln Ile His Leu Lys Glu Leu His Ala Ile 
            420                 425                 430         


Leu Arg Arg Gln Glu Glu Phe Tyr Pro Phe Leu Lys Glu Asn Arg Glu 
        435                 440                 445             


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Leu Thr Arg Lys Ser Glu 
465                 470                 475                 480 


Glu Ala Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala 
                485                 490                 495     


Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Glu Gln Leu 
            500                 505                 510         


Pro Asn Lys Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe 
        515                 520                 525             


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Arg Met 
    530                 535                 540                 


Arg Lys Pro Glu Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp 
545                 550                 555                 560 


Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu 
                565                 570                 575     


Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ile Gly 
            580                 585                 590         


Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu 
        595                 600                 605             


Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp 
    610                 615                 620                 


Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 
625                 630                 635                 640 


Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys 
                645                 650                 655     


Val Met Lys Gln Leu Lys Arg Arg His Tyr Thr Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Arg Lys Met Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr 
        675                 680                 685             


Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ser Asn Arg Asn Phe Met 
    690                 695                 700                 


Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Glu Ile Glu Lys 
705                 710                 715                 720 


Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu Gln Ile Ala Asp 
                725                 730                 735     


Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys 
            740                 745                 750         


Ile Val Asp Glu Leu Val Lys Val Met Gly His Lys Pro Glu Asn Ile 
        755                 760                 765             


Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Thr Lys Gly Leu Gln 
    770                 775                 780                 


Gln Ser Arg Glu Arg Lys Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu 
785                 790                 795                 800 


Glu Ser Gln Ile Leu Lys Glu Asn Pro Val Glu Asn Thr Gln Leu Gln 
                805                 810                 815     


Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr 
            820                 825                 830         


Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp 
        835                 840                 845             


His Ile Val Pro Gln Ser Phe Ile Lys Asp Asp Ser Ile Asp Asn Lys 
    850                 855                 860                 


Val Leu Thr Arg Ser Val Glu Asn Arg Gly Lys Ser Asp Asn Val Pro 
865                 870                 875                 880 


Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu 
                885                 890                 895     


Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
            900                 905                 910         


Glu Arg Gly Gly Leu Ser Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu 
    930                 935                 940                 


Asp Ser Arg Met Asn Thr Lys Arg Asp Lys Asn Asp Lys Pro Ile Arg 
945                 950                 955                 960 


Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg 
                965                 970                 975     


Lys Asp Phe Gln Leu Tyr Lys Val Arg Asp Ile Asn Asn Tyr His His 
            980                 985                 990         


Ala His Asp Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
        995                 1000                 1005             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1010                 1015                 1020             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1025                 1030                 1035             


Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1040                 1045                 1050             


Phe Phe  Lys Thr Glu Val Lys  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1055                 1060                 1065             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Val Val Trp 
    1070                 1075                 1080             


Asn Lys  Glu Lys Asp Phe Ala  Thr Val Arg Lys Val  Leu Ala Met 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Ser Lys Arg Glu Ser  Ala Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Lys Gly Trp  Asp Thr Arg Lys Tyr  Gly Gly Phe 
    1130                 1135                 1140             


Gly Ser  Pro Thr Val Ala Tyr  Ser Ile Leu Val Val  Ala Lys Val 
    1145                 1150                 1155             


Glu Lys  Gly Lys Ala Lys Lys  Leu Lys Ser Val Lys  Val Leu Val 
    1160                 1165                 1170             


Gly Ile  Thr Ile Met Glu Lys  Gly Ser Tyr Glu Lys  Asp Pro Ile 
    1175                 1180                 1185             


Gly Phe  Leu Glu Ala Lys Gly  Tyr Lys Asp Ile Lys  Lys Glu Leu 
    1190                 1195                 1200             


Ile Phe  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1205                 1210                 1215             


Arg Arg  Arg Met Leu Ala Ser  Ala Thr Glu Leu Gln  Lys Ala Asn 
    1220                 1225                 1230             


Glu Leu  Val Leu Pro Gln His  Leu Val Arg Leu Leu  Tyr Tyr Thr 
    1235                 1240                 1245             


Gln Asn  Ile Ser Ala Thr Thr  Gly Ser Asn Asn Leu  Gly Tyr Ile 
    1250                 1255                 1260             


Glu Gln  His Arg Glu Glu Phe  Lys Glu Ile Phe Glu  Lys Ile Ile 
    1265                 1270                 1275             


Asp Phe  Ser Glu Lys Tyr Ile  Leu Lys Asn Lys Val  Asn Ser Asn 
    1280                 1285                 1290             


Leu Lys  Ser Ser Phe Asp Glu  Gln Phe Ala Val Ser  Asp Ser Ile 
    1295                 1300                 1305             


Leu Leu  Ser Asn Ser Phe Val  Ser Leu Leu Lys Tyr  Thr Ser Phe 
    1310                 1315                 1320             


Gly Ala  Ser Gly Gly Phe Thr  Phe Leu Asp Leu Asp  Val Lys Gln 
    1325                 1330                 1335             


Gly Arg  Leu Arg Tyr Gln Thr  Val Thr Glu Val Leu  Asp Ala Thr 
    1340                 1345                 1350             


Leu Ile  Tyr Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Thr Asp 
    1355                 1360                 1365             


Leu Ser  Gln Leu Gly Gly Asp  
    1370                 1375 


<210>  114
<211>  1345
<212>  PRT
<213>  Streptococcus constellatus

<400>  114

Met Gly Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Thr Gly Glu Met Asn Lys Val Asp Glu Asn 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Asp Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu His His Pro Ile Phe Gly Asn Ile Ala Ala Glu Val Lys Tyr 
        115                 120                 125             


His Asp Asp Phe Pro Thr Ile Tyr His Leu Arg Arg His Leu Ala Asp 
    130                 135                 140                 


Thr Ser Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Tyr Glu Gly Asp Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Ala Leu Phe Lys Asp Phe Val Glu Glu Tyr 
            180                 185                 190         


Asp Lys Thr Ile Glu Glu Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Ser Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala His Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Asp Leu His Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Phe Leu Gly Glu Val Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Leu Lys 
                325                 330                 335     


Asp Phe Ile Lys Val Asn Ala Pro Asp Gln Tyr Asn Ala Ile Phe Lys 
            340                 345                 350         


Asp Lys Asn Lys Lys Gly Tyr Ala Ser Tyr Ile Glu Ser Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Lys Ile Asn 
    370                 375                 380                 


Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp 
465                 470                 475                 480 


Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Ala Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe Phe Asp Thr Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Val Asn Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ser Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asp Lys Ala Asn Glu Lys Thr Ile Glu Asp Ile Ile Gln Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Lys Ala Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Arg Ala Gln Ile Ile Asp Asp Val Asp Asp 
705                 710                 715                 720 


Ile Ala Asn Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly His Asn Pro Ala Asn Ile Ile Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Asp Lys Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Asn Leu Asp Asn Pro Val Asn Ile Lys Asn Val 
785                 790                 795                 800 


Glu Asn Gln Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu 
            820                 825                 830         


Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp 
        835                 840                 845             


Asn Ser Leu Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Ile Glu Val Val His Glu Met Lys Ser 
865                 870                 875                 880 


Phe Trp Ser Lys Leu Leu Ser Val Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Glu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Glu Arg Phe Asn Thr Glu Phe Asp Gly 
    930                 935                 940                 


Asn Lys Arg Arg Ile Arg Asn Val Lys Ile Ile Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Asn Ala Leu Leu Leu Lys Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Glu Tyr Pro Lys Tyr  Asn Ser Tyr Arg Ser  Arg Lys Ser 
    1010                 1015                 1020             


Ala Thr  Glu Lys Phe Leu Phe  Tyr Ser Asn Ile Leu  Arg Phe Phe 
    1025                 1030                 1035             


Lys Lys  Glu Asp Ile Gln Thr  Asn Glu Asp Gly Glu  Ile Ala Trp 
    1040                 1045                 1050             


Asn Lys  Glu Lys His Ile Lys  Ile Leu Arg Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Glu Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Asn  Ser Tyr Trp Asp Pro  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Val  Val Ala Tyr Ser Ile  Leu Val Phe 
    1115                 1120                 1125             


Ala Asp  Val Glu Lys Gly Lys  Ser Lys Lys Leu Arg  Lys Val Gln 
    1130                 1135                 1140             


Asp Met  Val Gly Ile Thr Ile  Met Glu Lys Lys Arg  Phe Glu Lys 
    1145                 1150                 1155             


Asn Pro  Val Asp Phe Leu Glu  Gln Arg Gly Tyr Arg  Asn Val Arg 
    1160                 1165                 1170             


Leu Glu  Lys Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1175                 1180                 1185             


Glu Asn  Lys Arg Arg Arg Leu  Leu Ala Ser Ala Lys  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Leu Val Ile  Pro Gln Arg Phe Thr  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ser Tyr Arg Ile Glu  Lys Asp Tyr Glu Pro  Glu His Arg 
    1220                 1225                 1230             


Glu Tyr  Val Glu Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Glu 
    1235                 1240                 1245             


Tyr Ile  Ser Val Phe Ser Arg  Lys Tyr Val Leu Ala  Asp Asn Asn 
    1250                 1255                 1260             


Leu Thr  Lys Ile Glu Met Leu  Phe Ser Lys Asn Lys  Asp Ala Glu 
    1265                 1270                 1275             


Val Ser  Ser Leu Ala Lys Ser  Phe Ile Ser Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Phe  Gly Ala Pro Ala Ala  Phe Asn Phe Phe Gly  Glu Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Val Thr Glu Cys Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Glu Asp  
    1340                 1345 


<210>  115
<211>  1365
<212>  PRT
<213>  Streptococcus constellatus

<400>  115

Met Thr Gln Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Ile Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Ile Leu Gly Asn Thr Asn Lys Gln Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Lys Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ile Glu Glu Met Asn Lys Val Asp Glu Asn 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Gly Thr Leu Lys Glu Glu Lys Glu Tyr 
        115                 120                 125             


Tyr Lys Glu Phe Glu Thr Ile Tyr His Leu Arg Lys Arg Leu Ala Asp 
    130                 135                 140                 


Ser Thr Gly Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Thr Leu Phe Asn Asp Phe Val Glu Val Tyr 
            180                 185                 190         


Asp Lys Thr Ile Glu Glu Ser His Leu Ala Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Val Lys Cys Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Thr Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Ala Val Asp Asp Asn Ser Thr Lys Ala Leu Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Leu Lys 
                325                 330                 335     


Asp Phe Ile Lys Val Asn Ala Pro Ala Gln Tyr Asp Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Asp 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Val Arg Lys Gly Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp 
465                 470                 475                 480 


Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Ile Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Pro Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Leu Asn Tyr Leu Asp Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asp Lys Ala Asn Glu Lys Thr Ile Glu Asp Ile Ile Gln Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Lys Ala Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Asn Lys Thr Ile Leu Glu Tyr Leu Val Asp Asp Gly 
        675                 680                 685             


Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Thr Leu Pro 
    690                 695                 700                 


Phe Lys Gln Ile Ile Lys Asp Ala Gln Ala Ile Asp Asp Val Asp Asp 
705                 710                 715                 720 


Ile Glu Leu Ile Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Tyr Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Thr Lys Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu 
    770                 775                 780                 


Gln Asp Ser Leu Thr Asn Leu Asp Asn Pro Val Ser Ile Lys Asn Val 
785                 790                 795                 800 


Glu Asn Gln Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile His His Leu 
            820                 825                 830         


Ser Asp Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Ala Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Asn Leu Glu Val Val Cys Asp Arg Lys Ala 
865                 870                 875                 880 


Asp Trp Ile Arg Leu Arg Glu Ala Gly Leu Ile Ser Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Asn Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile His Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Pro Lys Arg Asp Asp 
    930                 935                 940                 


Asn Lys Lys Val Ile Arg Asp Val Lys Ile Ile Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Gln Phe Arg Arg Asp Phe Lys Leu Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Leu Lys Lys Tyr  Pro Lys Leu Thr Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Glu Tyr Lys Lys Tyr  Asp Val Arg Lys Phe  Ile Ala Lys 
    1010                 1015                 1020             


Ser Asp  Asn Asp Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Thr Glu Val  Lys Phe Ala 
    1040                 1045                 1050             


Asp Gly  Thr Val Val Glu Arg  Pro Asp Ile Glu Thr  Ser Glu Asp 
    1055                 1060                 1065             


Gly Glu  Ile Ala Trp Asn Lys  Gln Thr Asp Phe Lys  Ile Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Tyr Pro Gln  Val Asn Ile Val Lys  Lys Val Glu 
    1085                 1090                 1095             


Lys Gln  Thr Gly Arg Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly 
    1100                 1105                 1110             


Asp Ser  Asp Lys Leu Ile Ala  Arg Lys Thr Lys Glu  Asn Tyr Trp 
    1115                 1120                 1125             


Asp Thr  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1130                 1135                 1140             


Ser Val  Leu Val Val Ala Asp  Ile Lys Lys Gly Lys  Ala Lys Lys 
    1145                 1150                 1155             


Leu Lys  Thr Val Lys Glu Leu  Val Gly Ile Ser Ile  Met Glu Arg 
    1160                 1165                 1170             


Pro Phe  Phe Glu Lys Asn Pro  Ile Met Phe Leu Glu  Ser Lys Gly 
    1175                 1180                 1185             


Tyr Arg  Asn Ile Gln Lys Asp  Lys Leu Ile Lys Leu  Pro Lys Tyr 
    1190                 1195                 1200             


Ser Leu  Phe Glu Phe Glu Gly  Gly Arg Arg Arg Leu  Leu Ala Ser 
    1205                 1210                 1215             


Ala Val  Glu Leu Gln Lys Gly  Asn Glu Met Val Leu  Pro Gln Tyr 
    1220                 1225                 1230             


Leu Asn  Asn Leu Leu Tyr His  Ala His Arg Ile Asp  Asn Ser Asp 
    1235                 1240                 1245             


Asn Ser  Glu His Leu Lys Tyr  Ile Thr Glu His Lys  Glu Glu Phe 
    1250                 1255                 1260             


Gly Lys  Leu Leu Ser Tyr Ile  Glu Asn Phe Ala Lys  Ser Tyr Val 
    1265                 1270                 1275             


Asp Val  Asp Lys Asn Leu Glu  Lys Ile Gln Leu Ala  Val Glu Lys 
    1280                 1285                 1290             


Ile Asp  Ser Phe Ser Val Lys  Glu Ile Ser Asn Ser  Phe Ile His 
    1295                 1300                 1305             


Leu Leu  Thr Leu Thr Ala Leu  Gly Ala Pro Ala Asp  Phe Asn Phe 
    1310                 1315                 1320             


Leu Gly  Glu Lys Ile Pro Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu 
    1325                 1330                 1335             


Cys Leu  Asn Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1340                 1345                 1350             


Glu Thr  Gln Thr Asp Leu Ser  Lys Leu Gly Glu Asp  
    1355                 1360                 1365 


<210>  116
<211>  1371
<212>  PRT
<213>  Streptococcus dysgalactiae

<400>  116

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Met Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gln 
    530                 535                 540                 


Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Lys Tyr Ala 
625                 630                 635                 640 


Asn Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Ile Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Thr Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Met Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Gly  Asp 
    1370     


<210>  117
<211>  1371
<212>  PRT
<213>  Streptococcus dysgalactiae

<400>  117

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Lys Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Lys Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asn Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gln 
    530                 535                 540                 


Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Lys Tyr Ala 
625                 630                 635                 640 


Asn Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Ile Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Gly  Asp 
    1370     


<210>  118
<211>  1371
<212>  PRT
<213>  Streptococcus dysgalactiae

<400>  118

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Met Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gln 
    530                 535                 540                 


Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Ile Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asn Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Ile Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Gly  Asp 
    1370     


<210>  119
<211>  1371
<212>  PRT
<213>  Streptococcus dysgalactiae

<400>  119

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Met Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gln 
    530                 535                 540                 


Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Lys Tyr Ala 
625                 630                 635                 640 


Asn Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Ile Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Gly  Asp 
    1370     


<210>  120
<211>  1308
<212>  PRT
<213>  Unknown

<220>
<223>  Acidaminococcus sp. (strain BV3L6)

<400>  120

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Arg Gln Arg Ser Leu Lys His 
                405                 410                 415     


Glu Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu 
            420                 425                 430         


Ser Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His 
        435                 440                 445             


Ala Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu 
    450                 455                 460                 


Lys Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His 
465                 470                 475                 480 


Leu Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu 
                485                 490                 495     


Phe Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu 
            500                 505                 510         


Ser Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser 
        515                 520                 525             


Val Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly 
    530                 535                 540                 


Trp Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys 
545                 550                 555                 560 


Asn Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr 
                565                 570                 575     


Lys Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp 
            580                 585                 590         


Lys Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys 
        595                 600                 605             


Cys Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr 
    610                 615                 620                 


Thr Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr 
625                 630                 635                 640 


Lys Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe 
                645                 650                 655     


Gln Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu 
            660                 665                 670         


Ala Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr 
        675                 680                 685             


Thr Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln 
    690                 695                 700                 


Tyr Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr 
705                 710                 715                 720 


His Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val 
                725                 730                 735     


Glu Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala 
            740                 745                 750         


Lys Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly 
        755                 760                 765             


Leu Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly 
    770                 775                 780                 


Gln Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala 
785                 790                 795                 800 


His Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys 
                805                 810                 815     


Thr Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn 
            820                 825                 830         


His Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro 
        835                 840                 845             


Asn Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg 
    850                 855                 860                 


Phe Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr 
865                 870                 875                 880 


Gln Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr 
                885                 890                 895     


Leu Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu 
            900                 905                 910         


Arg Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu 
        915                 920                 925             


Glu Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys 
    930                 935                 940                 


Leu Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser 
945                 950                 955                 960 


Val Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val 
                965                 970                 975     


Ile His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val 
            980                 985                 990         


Leu Glu Asn Leu Asn Phe Gly Phe  Lys Ser Lys Arg Thr  Gly Ile Ala 
        995                 1000                 1005             


Glu Lys  Ala Val Tyr Gln Gln  Phe Glu Lys Met Leu  Ile Asp Lys 
    1010                 1015                 1020             


Leu Asn  Cys Leu Val Leu Lys  Asp Tyr Pro Ala Glu  Lys Val Gly 
    1025                 1030                 1035             


Gly Val  Leu Asn Pro Tyr Gln  Leu Thr Asp Gln Phe  Thr Ser Phe 
    1040                 1045                 1050             


Ala Lys  Met Gly Thr Gln Ser  Gly Phe Leu Phe Tyr  Val Pro Ala 
    1055                 1060                 1065             


Pro Tyr  Thr Ser Lys Ile Asp  Pro Leu Thr Gly Phe  Val Asp Pro 
    1070                 1075                 1080             


Phe Val  Trp Lys Thr Ile Lys  Asn His Glu Ser Arg  Lys His Phe 
    1085                 1090                 1095             


Leu Glu  Gly Phe Asp Phe Leu  His Tyr Asp Val Lys  Thr Gly Asp 
    1100                 1105                 1110             


Phe Ile  Leu His Phe Lys Met  Asn Arg Asn Leu Ser  Phe Gln Arg 
    1115                 1120                 1125             


Gly Leu  Pro Gly Phe Met Pro  Ala Trp Asp Ile Val  Phe Glu Lys 
    1130                 1135                 1140             


Asn Glu  Thr Gln Phe Asp Ala  Lys Gly Thr Pro Phe  Ile Ala Gly 
    1145                 1150                 1155             


Lys Arg  Ile Val Pro Val Ile  Glu Asn His Arg Phe  Thr Gly Arg 
    1160                 1165                 1170             


Tyr Arg  Asp Leu Tyr Pro Ala  Asn Glu Leu Ile Ala  Leu Leu Glu 
    1175                 1180                 1185             


Glu Lys  Gly Ile Val Phe Arg  Asp Gly Ser Asn Ile  Leu Pro Lys 
    1190                 1195                 1200             


Leu Leu  Glu Asn Asp Asp Ser  His Ala Ile Asp Thr  Met Val Ala 
    1205                 1210                 1215             


Leu Ile  Arg Ser Val Leu Gln  Met Arg Asn Ser Asn  Ala Ala Thr 
    1220                 1225                 1230             


Gly Glu  Asp Tyr Ile Asn Ser  Pro Val Arg Asp Leu  Asn Gly Val 
    1235                 1240                 1245             


Cys Phe  Asp Ser Arg Phe Gln  Asn Pro Glu Trp Pro  Met Asp Ala 
    1250                 1255                 1260             


Asp Ala  Asn Gly Ala Tyr His  Ile Ala Leu Lys Gly  Gln Leu Leu 
    1265                 1270                 1275             


Leu Asn  His Leu Lys Glu Ser  Lys Asp Leu Lys Leu  Gln Asn Gly 
    1280                 1285                 1290             


Ile Ser  Asn Gln Asp Trp Leu  Ala Tyr Ile Gln Glu  Leu Arg Asn 
    1295                 1300                 1305             


<210>  121
<211>  1308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  121

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Arg Gln Arg Ser Leu Lys His 
                405                 410                 415     


Glu Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu 
            420                 425                 430         


Ser Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His 
        435                 440                 445             


Ala Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu 
    450                 455                 460                 


Lys Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His 
465                 470                 475                 480 


Leu Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu 
                485                 490                 495     


Phe Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu 
            500                 505                 510         


Ser Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser 
        515                 520                 525             


Val Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly 
    530                 535                 540                 


Trp Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys 
545                 550                 555                 560 


Asn Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr 
                565                 570                 575     


Lys Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp 
            580                 585                 590         


Lys Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys 
        595                 600                 605             


Cys Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr 
    610                 615                 620                 


Thr Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr 
625                 630                 635                 640 


Lys Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe 
                645                 650                 655     


Gln Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu 
            660                 665                 670         


Ala Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr 
        675                 680                 685             


Thr Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln 
    690                 695                 700                 


Tyr Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr 
705                 710                 715                 720 


His Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val 
                725                 730                 735     


Glu Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala 
            740                 745                 750         


Lys Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly 
        755                 760                 765             


Leu Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly 
    770                 775                 780                 


Gln Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala 
785                 790                 795                 800 


His Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys 
                805                 810                 815     


Thr Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn 
            820                 825                 830         


His Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro 
        835                 840                 845             


Asn Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg 
    850                 855                 860                 


Phe Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr 
865                 870                 875                 880 


Gln Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr 
                885                 890                 895     


Leu Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu 
            900                 905                 910         


Arg Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu 
        915                 920                 925             


Glu Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys 
    930                 935                 940                 


Leu Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser 
945                 950                 955                 960 


Val Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val 
                965                 970                 975     


Ile His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val 
            980                 985                 990         


Leu Glu Asn Leu Asn Phe Gly Phe  Lys Ser Lys Arg Thr  Gly Ile Ala 
        995                 1000                 1005             


Glu Lys  Ala Val Tyr Gln Gln  Phe Glu Lys Met Leu  Ile Asp Lys 
    1010                 1015                 1020             


Leu Asn  Cys Leu Val Leu Lys  Asp Tyr Pro Ala Glu  Lys Val Gly 
    1025                 1030                 1035             


Gly Val  Leu Asn Pro Tyr Gln  Leu Thr Asp Gln Phe  Thr Ser Phe 
    1040                 1045                 1050             


Ala Lys  Met Gly Thr Gln Ser  Gly Phe Leu Phe Tyr  Val Pro Ala 
    1055                 1060                 1065             


Pro Tyr  Thr Ser Lys Ile Asp  Pro Leu Thr Gly Phe  Val Asp Pro 
    1070                 1075                 1080             


Phe Val  Trp Lys Thr Ile Lys  Asn His Glu Ser Arg  Lys His Phe 
    1085                 1090                 1095             


Leu Glu  Gly Phe Asp Phe Leu  His Tyr Asp Val Lys  Thr Gly Asp 
    1100                 1105                 1110             


Phe Ile  Leu His Phe Lys Met  Asn Arg Asn Leu Ser  Phe Gln Arg 
    1115                 1120                 1125             


Gly Leu  Pro Gly Phe Met Pro  Ala Trp Asp Ile Val  Phe Glu Lys 
    1130                 1135                 1140             


Asn Glu  Thr Gln Phe Asp Ala  Lys Gly Thr Pro Phe  Ile Ala Gly 
    1145                 1150                 1155             


Lys Arg  Ile Val Pro Val Ile  Glu Asn His Arg Phe  Thr Gly Arg 
    1160                 1165                 1170             


Tyr Arg  Asp Leu Tyr Pro Ala  Asn Glu Leu Ile Ala  Leu Leu Glu 
    1175                 1180                 1185             


Glu Lys  Gly Ile Val Phe Arg  Asp Gly Ser Asn Ile  Leu Pro Lys 
    1190                 1195                 1200             


Leu Leu  Glu Asn Asp Asp Ser  His Ala Ile Asp Thr  Met Val Ala 
    1205                 1210                 1215             


Leu Ile  Arg Ser Val Leu Gln  Met Ala Asn Ser Asn  Ala Ala Thr 
    1220                 1225                 1230             


Gly Glu  Asp Tyr Ile Asn Ser  Pro Val Arg Asp Leu  Asn Gly Val 
    1235                 1240                 1245             


Cys Phe  Asp Ser Arg Phe Gln  Asn Pro Glu Trp Pro  Met Asp Ala 
    1250                 1255                 1260             


Asp Ala  Asn Gly Ala Tyr His  Ile Ala Leu Lys Gly  Gln Leu Leu 
    1265                 1270                 1275             


Leu Asn  His Leu Lys Glu Ser  Lys Asp Leu Lys Leu  Gln Asn Gly 
    1280                 1285                 1290             


Ile Ser  Asn Gln Asp Trp Leu  Ala Tyr Ile Gln Glu  Leu Arg Asn 
    1295                 1300                 1305             


<210>  122
<211>  1259
<212>  PRT
<213>  Unknown

<220>
<223>  Lachnospiraceae bacterium GAM79

<400>  122

Met Asn Tyr Lys Thr Gly Leu Glu Asp Phe Ile Gly Lys Glu Ser Leu 
1               5                   10                  15      


Ser Lys Thr Leu Arg Asn Ala Leu Ile Pro Thr Glu Ser Thr Lys Ile 
            20                  25                  30          


His Met Glu Glu Met Gly Val Ile Arg Asp Asp Glu Leu Arg Ala Glu 
        35                  40                  45              


Lys Gln Gln Glu Leu Lys Glu Ile Met Asp Asp Tyr Tyr Arg Thr Phe 
    50                  55                  60                  


Ile Glu Glu Lys Leu Gly Gln Ile Gln Gly Ile Gln Trp Asn Ser Leu 
65                  70                  75                  80  


Phe Gln Lys Met Glu Glu Thr Met Glu Asp Ile Ser Val Arg Lys Asp 
                85                  90                  95      


Leu Asp Lys Ile Gln Asn Glu Lys Arg Lys Glu Ile Cys Cys Tyr Phe 
            100                 105                 110         


Thr Ser Asp Lys Arg Phe Lys Asp Leu Phe Asn Ala Lys Leu Ile Thr 
        115                 120                 125             


Asp Ile Leu Pro Asn Phe Ile Lys Asp Asn Lys Glu Tyr Thr Glu Glu 
    130                 135                 140                 


Glu Lys Ala Glu Lys Glu Gln Thr Arg Val Leu Phe Gln Arg Phe Ala 
145                 150                 155                 160 


Thr Ala Phe Thr Asn Tyr Phe Asn Gln Arg Arg Asn Asn Phe Ser Glu 
                165                 170                 175     


Asp Asn Ile Ser Thr Ala Ile Ser Phe Arg Ile Val Asn Glu Asn Ser 
            180                 185                 190         


Glu Ile His Leu Gln Asn Met Arg Ala Phe Gln Arg Ile Glu Gln Gln 
        195                 200                 205             


Tyr Pro Glu Glu Val Cys Gly Met Glu Glu Glu Tyr Lys Asp Met Leu 
    210                 215                 220                 


Gln Glu Trp Gln Met Lys His Ile Tyr Ser Val Asp Phe Tyr Asp Arg 
225                 230                 235                 240 


Glu Leu Thr Gln Pro Gly Ile Glu Tyr Tyr Asn Gly Ile Cys Gly Lys 
                245                 250                 255     


Ile Asn Glu His Met Asn Gln Phe Cys Gln Lys Asn Arg Ile Asn Lys 
            260                 265                 270         


Asn Asp Phe Arg Met Lys Lys Leu His Lys Gln Ile Leu Cys Lys Lys 
        275                 280                 285             


Ser Ser Tyr Tyr Glu Ile Pro Phe Arg Phe Glu Ser Asp Gln Glu Val 
    290                 295                 300                 


Tyr Asp Ala Leu Asn Glu Phe Ile Lys Thr Met Lys Lys Lys Glu Ile 
305                 310                 315                 320 


Ile Arg Arg Cys Val His Leu Gly Gln Glu Cys Asp Asp Tyr Asp Leu 
                325                 330                 335     


Gly Lys Ile Tyr Ile Ser Ser Asn Lys Tyr Glu Gln Ile Ser Asn Ala 
            340                 345                 350         


Leu Tyr Gly Ser Trp Asp Thr Ile Arg Lys Cys Ile Lys Glu Glu Tyr 
        355                 360                 365             


Met Asp Ala Leu Pro Gly Lys Gly Glu Lys Lys Glu Glu Lys Ala Glu 
    370                 375                 380                 


Ala Ala Ala Lys Lys Glu Glu Tyr Arg Ser Ile Ala Asp Ile Asp Lys 
385                 390                 395                 400 


Ile Ile Ser Leu Tyr Gly Ser Glu Met Asp Arg Thr Ile Ser Ala Lys 
                405                 410                 415     


Lys Cys Ile Thr Glu Ile Cys Asp Met Ala Gly Gln Ile Ser Ile Asp 
            420                 425                 430         


Pro Leu Val Cys Asn Ser Asp Ile Lys Leu Leu Gln Asn Lys Glu Lys 
        435                 440                 445             


Thr Thr Glu Ile Lys Thr Ile Leu Asp Ser Phe Leu His Val Tyr Gln 
    450                 455                 460                 


Trp Gly Gln Thr Phe Ile Val Ser Asp Ile Ile Glu Lys Asp Ser Tyr 
465                 470                 475                 480 


Phe Tyr Ser Glu Leu Glu Asp Val Leu Glu Asp Phe Glu Gly Ile Thr 
                485                 490                 495     


Thr Leu Tyr Asn His Val Arg Ser Tyr Val Thr Gln Lys Pro Tyr Ser 
            500                 505                 510         


Thr Val Lys Phe Lys Leu His Phe Gly Ser Pro Thr Leu Ala Asn Gly 
        515                 520                 525             


Trp Ser Gln Ser Lys Glu Tyr Asp Asn Asn Ala Ile Leu Leu Met Arg 
    530                 535                 540                 


Asp Gln Lys Phe Tyr Leu Gly Ile Phe Asn Val Arg Asn Lys Pro Asp 
545                 550                 555                 560 


Lys Gln Ile Ile Lys Gly His Glu Lys Glu Glu Lys Gly Asp Tyr Lys 
                565                 570                 575     


Lys Met Ile Tyr Asn Leu Leu Pro Gly Pro Ser Lys Met Leu Pro Lys 
            580                 585                 590         


Val Phe Ile Thr Ser Arg Ser Gly Gln Glu Thr Tyr Lys Pro Ser Lys 
        595                 600                 605             


His Ile Leu Asp Gly Tyr Asn Glu Lys Arg His Ile Lys Ser Ser Pro 
    610                 615                 620                 


Lys Phe Asp Leu Gly Tyr Cys Trp Asp Leu Ile Asp Tyr Tyr Lys Glu 
625                 630                 635                 640 


Cys Ile His Lys His Pro Asp Trp Lys Asn Tyr Asp Phe His Phe Ser 
                645                 650                 655     


Asp Thr Lys Asp Tyr Glu Asp Ile Ser Gly Phe Tyr Arg Glu Val Glu 
            660                 665                 670         


Met Gln Gly Tyr Gln Ile Lys Trp Thr Tyr Ile Ser Ala Asp Glu Ile 
        675                 680                 685             


Gln Lys Leu Asp Glu Lys Gly Gln Ile Phe Leu Phe Gln Ile Tyr Asn 
    690                 695                 700                 


Lys Asp Phe Ser Val His Ser Thr Gly Lys Asp Asn Leu His Thr Met 
705                 710                 715                 720 


Tyr Leu Lys Asn Leu Phe Ser Glu Glu Asn Leu Lys Asp Ile Val Leu 
                725                 730                 735     


Lys Leu Asn Gly Glu Ala Glu Leu Phe Phe Arg Lys Ala Ser Ile Lys 
            740                 745                 750         


Thr Pro Ile Val His Lys Lys Gly Ser Val Leu Val Asn Arg Ser Tyr 
        755                 760                 765             


Thr Gln Thr Val Gly Asn Lys Glu Ile Arg Val Ser Ile Pro Glu Glu 
    770                 775                 780                 


Tyr Tyr Thr Glu Ile Tyr Asn Tyr Leu Asn His Ile Gly Lys Gly Lys 
785                 790                 795                 800 


Leu Ser Ser Glu Ala Gln Arg Tyr Leu Asp Glu Gly Lys Ile Lys Ser 
                805                 810                 815     


Phe Thr Ala Thr Lys Asp Ile Val Lys Asn Tyr Arg Tyr Cys Cys Asp 
            820                 825                 830         


His Tyr Phe Leu His Leu Pro Ile Thr Ile Asn Phe Lys Ala Lys Ser 
        835                 840                 845             


Asp Val Ala Val Asn Glu Arg Thr Leu Ala Tyr Ile Ala Lys Lys Glu 
    850                 855                 860                 


Asp Ile His Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr 
865                 870                 875                 880 


Ile Ser Val Val Asp Val His Gly Asn Ile Arg Glu Gln Arg Ser Phe 
                885                 890                 895     


Asn Ile Val Asn Gly Tyr Asp Tyr Gln Gln Lys Leu Lys Asp Arg Glu 
            900                 905                 910         


Lys Ser Arg Asp Ala Ala Arg Lys Asn Trp Glu Glu Ile Glu Lys Ile 
        915                 920                 925             


Lys Glu Leu Lys Glu Gly Tyr Leu Ser Met Val Ile His Tyr Ile Ala 
    930                 935                 940                 


Gln Leu Val Val Lys Tyr Asn Ala Val Val Ala Met Glu Asp Leu Asn 
945                 950                 955                 960 


Tyr Gly Phe Lys Thr Gly Arg Phe Lys Val Glu Arg Gln Val Tyr Gln 
                965                 970                 975     


Lys Phe Glu Thr Met Leu Ile Glu Lys Leu His Tyr Leu Val Phe Lys 
            980                 985                 990         


Asp Arg Glu Val Cys Glu Glu Gly  Gly Val Leu Arg Gly  Tyr Gln Leu 
        995                 1000                 1005             


Thr Tyr  Ile Pro Glu Ser Leu  Lys Lys Val Gly Lys  Gln Cys Gly 
    1010                 1015                 1020             


Phe Ile  Phe Tyr Val Pro Ala  Gly Tyr Thr Ser Lys  Ile Asp Pro 
    1025                 1030                 1035             


Thr Thr  Gly Phe Val Asn Leu  Phe Ser Phe Lys Asn  Leu Thr Asn 
    1040                 1045                 1050             


Arg Glu  Ser Arg Gln Asp Phe  Val Gly Lys Phe Asp  Glu Ile Arg 
    1055                 1060                 1065             


Tyr Asp  Arg Asp Lys Lys Met  Phe Glu Phe Ser Phe  Asp Tyr Asn 
    1070                 1075                 1080             


Asn Tyr  Ile Lys Lys Gly Thr  Ile Leu Ala Ser Thr  Lys Trp Lys 
    1085                 1090                 1095             


Val Tyr  Thr Asn Gly Thr Arg  Leu Lys Arg Ile Val  Val Asn Gly 
    1100                 1105                 1110             


Lys Tyr  Thr Ser Gln Ser Met  Glu Val Glu Leu Thr  Asp Ala Met 
    1115                 1120                 1125             


Glu Lys  Met Leu Gln Arg Ala  Gly Ile Glu Tyr His  Asp Gly Lys 
    1130                 1135                 1140             


Asp Leu  Lys Gly Gln Ile Val  Glu Lys Gly Ile Glu  Ala Glu Ile 
    1145                 1150                 1155             


Ile Asp  Ile Phe Arg Leu Thr  Val Gln Met Arg Asn  Ser Arg Ser 
    1160                 1165                 1170             


Glu Ser  Glu Asp Arg Glu Tyr  Asp Arg Leu Ile Ser  Pro Val Leu 
    1175                 1180                 1185             


Asn Asp  Lys Gly Glu Phe Phe  Asp Thr Ala Thr Ala  Asp Lys Thr 
    1190                 1195                 1200             


Leu Pro  Gln Asp Ala Asp Ala  Asn Gly Ala Tyr Cys  Ile Ala Leu 
    1205                 1210                 1215             


Lys Gly  Leu Tyr Glu Val Lys  Gln Ile Lys Glu Asn  Trp Lys Glu 
    1220                 1225                 1230             


Asn Glu  Gln Phe Pro Arg Asn  Lys Leu Val Gln Asp  Asn Lys Thr 
    1235                 1240                 1245             


Trp Phe  Asp Phe Met Gln Lys  Lys Arg Tyr Leu 
    1250                 1255                 


<210>  123
<211>  1306
<212>  PRT
<213>  Prevotella copri

<400>  123

Met Ala Lys Asn Phe Glu Asp Phe Lys Arg Leu Tyr Ser Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Ala Lys Pro Ile Gly Ala Thr Leu Asp Asn Ile 
            20                  25                  30          


Val Lys Ser Gly Leu Leu Asp Glu Asp Glu His Arg Ala Ala Ser Tyr 
        35                  40                  45              


Val Lys Val Lys Lys Leu Ile Asp Glu Tyr His Lys Val Phe Ile Asp 
    50                  55                  60                  


Arg Val Leu Asp Asp Gly Cys Leu Pro Leu Glu Asn Lys Gly Asn Asn 
65                  70                  75                  80  


Asn Ser Leu Ala Glu Tyr Tyr Glu Ser Tyr Val Ser Arg Ala Gln Asp 
                85                  90                  95      


Glu Asp Ala Lys Lys Lys Phe Lys Glu Ile Gln Gln Asn Leu Arg Ser 
            100                 105                 110         


Val Ile Ala Lys Lys Leu Thr Glu Asp Lys Ala Tyr Ala Asn Leu Phe 
        115                 120                 125             


Gly Asn Lys Leu Ile Glu Ser Tyr Lys Asp Lys Glu Asp Lys Lys Lys 
    130                 135                 140                 


Ile Ile Asp Ser Asp Leu Ile Gln Phe Ile Asn Thr Ala Glu Ser Thr 
145                 150                 155                 160 


Gln Leu Asp Ser Met Ser Gln Asp Glu Ala Lys Glu Leu Val Lys Glu 
                165                 170                 175     


Phe Trp Gly Phe Val Thr Tyr Phe Tyr Gly Phe Phe Asp Asn Arg Lys 
            180                 185                 190         


Asn Met Tyr Thr Ala Glu Glu Lys Ser Thr Gly Ile Ala Tyr Arg Leu 
        195                 200                 205             


Val Asn Glu Asn Leu Pro Lys Phe Ile Asp Asn Ile Glu Ala Phe Asn 
    210                 215                 220                 


Arg Ala Ile Thr Arg Pro Glu Ile Gln Glu Asn Met Gly Val Leu Tyr 
225                 230                 235                 240 


Ser Asp Phe Ser Glu Tyr Leu Asn Val Glu Ser Ile Gln Glu Met Phe 
                245                 250                 255     


Gln Leu Asp Tyr Tyr Asn Met Leu Leu Thr Gln Lys Gln Ile Asp Val 
            260                 265                 270         


Tyr Asn Ala Ile Ile Gly Gly Lys Thr Asp Asp Glu His Asp Val Lys 
        275                 280                 285             


Ile Lys Gly Ile Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Gln His Lys 
    290                 295                 300                 


Asp Asp Lys Leu Pro Lys Leu Lys Ala Leu Phe Lys Gln Ile Leu Ser 
305                 310                 315                 320 


Asp Arg Asn Ala Ile Ser Trp Leu Pro Glu Glu Phe Asn Ser Asp Gln 
                325                 330                 335     


Glu Val Leu Asn Ala Ile Lys Asp Cys Tyr Glu Arg Leu Ala Glu Asn 
            340                 345                 350         


Val Leu Gly Asp Lys Val Leu Lys Ser Leu Leu Gly Ser Leu Ala Asp 
        355                 360                 365             


Tyr Ser Leu Asp Gly Ile Phe Ile Arg Asn Asp Leu Gln Leu Thr Asp 
    370                 375                 380                 


Ile Ser Gln Lys Met Phe Gly Asn Trp Gly Val Ile Gln Asn Ala Ile 
385                 390                 395                 400 


Met Gln Asn Ile Lys Arg Val Ala Pro Ala Arg Lys His Lys Glu Ser 
                405                 410                 415     


Glu Glu Asp Tyr Glu Lys Arg Ile Ala Gly Ile Phe Lys Lys Ala Asp 
            420                 425                 430         


Ser Phe Ser Ile Ser Tyr Ile Asn Asp Cys Leu Asn Glu Ala Asp Pro 
        435                 440                 445             


Asn Asn Ala Tyr Phe Val Glu Asn Tyr Phe Ala Thr Phe Gly Ala Val 
    450                 455                 460                 


Asn Thr Pro Thr Met Gln Arg Glu Asn Leu Phe Ala Leu Val Gln Asn 
465                 470                 475                 480 


Ala Tyr Thr Glu Val Ala Ala Leu Leu His Ser Asp Tyr Pro Thr Val 
                485                 490                 495     


Lys His Leu Ala Gln Asp Lys Ala Asn Val Ser Lys Ile Lys Ala Leu 
            500                 505                 510         


Leu Asp Ala Ile Lys Ser Leu Gln His Phe Val Lys Pro Leu Leu Gly 
        515                 520                 525             


Lys Gly Asp Glu Ser Asp Lys Asp Glu Arg Phe Tyr Gly Glu Leu Ala 
    530                 535                 540                 


Ser Leu Trp Ala Glu Leu Asp Thr Val Thr Pro Leu Tyr Asn Met Ile 
545                 550                 555                 560 


Arg Asn Tyr Met Thr Arg Lys Pro Tyr Ser Gln Lys Lys Ile Lys Leu 
                565                 570                 575     


Asn Phe Glu Asn Pro Gln Leu Leu Gly Gly Trp Asp Ala Asn Lys Glu 
            580                 585                 590         


Lys Asp Tyr Ala Thr Ile Ile Leu Arg Arg Asn Gly Leu Tyr Tyr Leu 
        595                 600                 605             


Ala Ile Met Asp Lys Asp Ser Arg Lys Leu Leu Gly Lys Ala Met Pro 
    610                 615                 620                 


Ser Asp Gly Glu Cys Tyr Glu Lys Met Val Tyr Lys Phe Phe Lys Asp 
625                 630                 635                 640 


Val Thr Thr Met Ile Pro Lys Cys Ser Thr Gln Leu Lys Asp Val Gln 
                645                 650                 655     


Ala Tyr Phe Lys Val Asn Thr Asp Asp Tyr Val Leu Asn Ser Lys Ala 
            660                 665                 670         


Phe Asn Lys Pro Leu Thr Ile Thr Lys Glu Val Phe Asp Leu Asn Asn 
        675                 680                 685             


Val Leu Tyr Gly Lys Tyr Lys Lys Phe Gln Lys Gly Tyr Leu Thr Ala 
    690                 695                 700                 


Thr Gly Asp Asn Val Gly Tyr Thr His Ala Val Asn Val Trp Ile Lys 
705                 710                 715                 720 


Phe Cys Met Asp Phe Leu Asn Ser Tyr Asp Ser Thr Cys Ile Tyr Asp 
                725                 730                 735     


Phe Ser Ser Leu Lys Pro Glu Ser Tyr Leu Ser Leu Asp Ala Phe Tyr 
            740                 745                 750         


Gln Asp Ala Asn Leu Leu Leu Tyr Lys Leu Ser Phe Ala Arg Ala Ser 
        755                 760                 765             


Val Ser Tyr Ile Asn Gln Leu Val Glu Glu Gly Lys Met Tyr Leu Phe 
    770                 775                 780                 


Gln Ile Tyr Asn Lys Asp Phe Ser Glu Tyr Ser Lys Gly Thr Pro Asn 
785                 790                 795                 800 


Met His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn Leu Ala 
                805                 810                 815     


Asp Val Val Tyr Lys Leu Asn Gly Gln Ala Glu Met Phe Tyr Arg Lys 
            820                 825                 830         


Lys Ser Ile Glu Asn Thr His Pro Thr His Pro Ala Asn His Pro Ile 
        835                 840                 845             


Leu Asn Lys Asn Lys Asp Asn Lys Lys Lys Glu Ser Leu Phe Asp Tyr 
    850                 855                 860                 


Asp Leu Ile Lys Asp Arg Arg Tyr Thr Val Asp Lys Phe Met Phe His 
865                 870                 875                 880 


Val Pro Ile Thr Met Asn Phe Lys Ser Val Gly Ser Glu Asn Ile Asn 
                885                 890                 895     


Gln Asp Val Lys Ala Tyr Leu Arg His Ala Asp Asp Met His Ile Ile 
            900                 905                 910         


Gly Ile Asp Arg Gly Glu Arg His Leu Leu Tyr Leu Val Val Ile Asp 
        915                 920                 925             


Leu Gln Gly Asn Ile Lys Glu Gln Tyr Ser Leu Asn Glu Ile Val Asn 
    930                 935                 940                 


Glu Tyr Asn Gly Asn Thr Tyr His Thr Asn Tyr His Asp Leu Leu Asp 
945                 950                 955                 960 


Val Arg Glu Glu Glu Arg Leu Lys Ala Arg Gln Ser Trp Gln Thr Ile 
                965                 970                 975     


Glu Asn Ile Lys Glu Leu Lys Glu Gly Tyr Leu Ser Gln Val Ile His 
            980                 985                 990         


Lys Ile Thr Gln Leu Met Val Arg  Tyr His Ala Ile Val  Val Leu Glu 
        995                 1000                 1005             


Asp Leu  Ser Lys Gly Phe Met  Arg Ser Arg Gln Lys  Val Glu Lys 
    1010                 1015                 1020             


Gln Val  Tyr Gln Lys Phe Glu  Lys Met Leu Ile Asp  Lys Leu Asn 
    1025                 1030                 1035             


Tyr Leu  Val Asp Lys Lys Thr  Asp Val Ser Thr Pro  Gly Gly Leu 
    1040                 1045                 1050             


Leu Asn  Ala Tyr Gln Leu Thr  Cys Lys Ser Asp Ser  Ser Gln Lys 
    1055                 1060                 1065             


Leu Gly  Lys Gln Ser Gly Phe  Leu Phe Tyr Ile Pro  Ala Trp Asn 
    1070                 1075                 1080             


Thr Ser  Lys Ile Asp Pro Val  Thr Gly Phe Val Asn  Leu Leu Asp 
    1085                 1090                 1095             


Thr His  Ser Leu Asn Ser Lys  Glu Lys Ile Lys Ala  Phe Phe Ser 
    1100                 1105                 1110             


Lys Phe  Asp Ala Ile Arg Tyr  Asn Lys Asp Lys Lys  Trp Phe Glu 
    1115                 1120                 1125             


Phe Asn  Leu Asp Tyr Asp Lys  Phe Gly Lys Lys Ala  Glu Asp Thr 
    1130                 1135                 1140             


Arg Thr  Lys Trp Thr Leu Cys  Thr Arg Gly Met Arg  Ile Asp Thr 
    1145                 1150                 1155             


Phe Arg  Asn Lys Glu Lys Asn  Ser Gln Trp Asp Asn  Gln Glu Val 
    1160                 1165                 1170             


Asp Leu  Thr Thr Glu Met Lys  Ser Leu Leu Glu His  Tyr Tyr Ile 
    1175                 1180                 1185             


Asp Ile  His Gly Asn Leu Lys  Asp Ala Ile Ser Ala  Gln Thr Asp 
    1190                 1195                 1200             


Lys Ala  Phe Phe Thr Gly Leu  Leu His Ile Leu Lys  Leu Thr Leu 
    1205                 1210                 1215             


Gln Met  Arg Asn Ser Ile Thr  Gly Thr Glu Thr Asp  Tyr Leu Val 
    1220                 1225                 1230             


Ser Pro  Val Ala Asp Glu Asn  Gly Ile Phe Tyr Asp  Ser Arg Ser 
    1235                 1240                 1245             


Cys Gly  Asn Gln Leu Pro Glu  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1250                 1255                 1260             


Asn Ile  Ala Arg Lys Gly Leu  Met Leu Ile Glu Gln  Ile Lys Asn 
    1265                 1270                 1275             


Ala Glu  Asp Leu Asn Asn Val  Lys Phe Asp Ile Ser  Asn Lys Ala 
    1280                 1285                 1290             


Trp Leu  Asn Phe Ala Gln Gln  Lys Pro Tyr Lys Asn  Gly 
    1295                 1300                 1305     


<210>  124
<211>  1142
<212>  PRT
<213>  Eubacterium rectale

<400>  124

Met Phe Ser Ala Lys Leu Ile Ser Asp Ile Leu Pro Glu Phe Val Ile 
1               5                   10                  15      


His Asn Asn Asn Tyr Ser Ala Ser Glu Lys Glu Glu Lys Thr Gln Val 
            20                  25                  30          


Ile Lys Leu Phe Ser Arg Phe Ala Thr Ser Phe Lys Asp Tyr Phe Lys 
        35                  40                  45              


Asn Arg Ala Asn Cys Phe Ser Ala Asn Asp Ile Ser Ser Ser Ser Cys 
    50                  55                  60                  


His Arg Ile Val Asn Asp Asn Ala Glu Ile Phe Phe Ser Asn Ala Leu 
65                  70                  75                  80  


Val Tyr Arg Arg Ile Val Lys Asn Leu Ser Asn Asp Asp Ile Asn Lys 
                85                  90                  95      


Ile Ser Gly Asp Met Lys Asp Ser Leu Lys Glu Met Ser Leu Glu Glu 
            100                 105                 110         


Ile Tyr Ser Tyr Glu Lys Tyr Gly Glu Phe Ile Thr Gln Glu Gly Ile 
        115                 120                 125             


Ser Phe Tyr Asn Asp Ile Cys Gly Lys Val Asn Leu Phe Met Asn Leu 
    130                 135                 140                 


Tyr Cys Gln Lys Asn Lys Glu Asn Lys Asn Leu Tyr Lys Leu Arg Lys 
145                 150                 155                 160 


Leu His Lys Gln Ile Leu Cys Ile Ala Asp Thr Ser Tyr Glu Val Pro 
                165                 170                 175     


Tyr Lys Phe Glu Ser Asp Glu Glu Val Tyr Gln Ser Val Asn Gly Phe 
            180                 185                 190         


Leu Asp Asn Ile Ser Ser Lys His Ile Val Glu Arg Leu Arg Lys Ile 
        195                 200                 205             


Gly Glu Asn Tyr Asn Gly Tyr Asn Leu Asp Lys Ile Tyr Ile Val Ser 
    210                 215                 220                 


Lys Phe Tyr Glu Ser Val Ser Gln Lys Thr Tyr Arg Asp Trp Glu Thr 
225                 230                 235                 240 


Ile Asn Thr Ala Leu Glu Ile His Tyr Asn Asn Ile Leu Pro Gly Asn 
                245                 250                 255     


Gly Lys Ser Lys Ala Asp Lys Val Lys Lys Ala Val Lys Asn Asp Leu 
            260                 265                 270         


Gln Lys Ser Ile Thr Glu Ile Asn Glu Leu Val Ser Asn Tyr Lys Leu 
        275                 280                 285             


Cys Pro Asp Asp Asn Ile Lys Ala Glu Thr Tyr Ile His Glu Ile Ser 
    290                 295                 300                 


His Ile Leu Asn Asn Phe Glu Ala Gln Glu Leu Lys Tyr Asn Pro Glu 
305                 310                 315                 320 


Ile His Leu Val Glu Ser Glu Leu Lys Ala Ser Glu Leu Lys Asn Val 
                325                 330                 335     


Leu Asp Val Ile Met Asn Ala Phe His Trp Cys Ser Val Phe Met Thr 
            340                 345                 350         


Glu Glu Leu Val Asp Lys Asp Asn Asn Phe Tyr Ala Glu Leu Glu Glu 
        355                 360                 365             


Ile Tyr Asp Glu Ile Tyr Pro Val Ile Ser Leu Tyr Asn Leu Val Arg 
    370                 375                 380                 


Asn Tyr Val Thr Gln Lys Pro Tyr Ser Thr Lys Lys Ile Lys Leu Asn 
385                 390                 395                 400 


Phe Gly Ile Pro Thr Leu Ala Asp Gly Trp Ser Lys Ser Lys Glu Tyr 
                405                 410                 415     


Ser Asn Asn Ala Ile Ile Leu Met Arg Asp Asn Leu Tyr Tyr Leu Gly 
            420                 425                 430         


Ile Phe Asn Ala Lys Asn Lys Pro Asp Lys Lys Ile Ile Glu Gly Asn 
        435                 440                 445             


Thr Ser Glu Asn Lys Gly Asp Tyr Lys Lys Met Ile Tyr Asn Leu Leu 
    450                 455                 460                 


Pro Gly Pro Asn Lys Met Ile Pro Lys Val Phe Leu Ser Ser Lys Thr 
465                 470                 475                 480 


Gly Val Glu Thr Tyr Lys Pro Ser Ala Tyr Ile Leu Glu Gly Tyr Lys 
                485                 490                 495     


Gln Asn Lys His Leu Lys Ser Ser Lys Asp Phe Asp Ile Thr Phe Cys 
            500                 505                 510         


His Asp Leu Ile Asp Tyr Phe Lys Asn Cys Ile Ala Ile His Pro Glu 
        515                 520                 525             


Trp Lys Asn Phe Gly Phe Asp Phe Ser Asp Thr Ser Thr Tyr Glu Asp 
    530                 535                 540                 


Ile Ser Gly Phe Tyr Arg Glu Val Glu Leu Gln Gly Tyr Lys Ile Asp 
545                 550                 555                 560 


Trp Thr Tyr Ile Ser Glu Lys Asp Ile Asp Leu Leu Gln Glu Lys Gly 
                565                 570                 575     


Gln Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Lys Lys Ser 
            580                 585                 590         


Ser Gly Asn Asp Asn Leu His Thr Met Tyr Leu Lys Asn Leu Phe Ser 
        595                 600                 605             


Glu Glu Asn Leu Lys Asp Ile Val Leu Lys Leu Asn Gly Glu Ala Glu 
    610                 615                 620                 


Ile Phe Phe Arg Lys Ser Ser Ile Lys Asn Pro Ile Ile His Lys Lys 
625                 630                 635                 640 


Gly Ser Ile Leu Val Asn Arg Thr Tyr Glu Ala Glu Glu Lys Asp Gln 
                645                 650                 655     


Phe Gly Asn Ile Gln Ile Val Arg Lys Thr Ile Pro Glu Asn Ile Tyr 
            660                 665                 670         


Gln Glu Leu Tyr Lys Tyr Phe Asn Asp Lys Ser Asp Lys Glu Leu Ser 
        675                 680                 685             


Asp Glu Ala Ala Lys Leu Lys Asn Val Val Gly His His Glu Ala Ala 
    690                 695                 700                 


Thr Asn Ile Val Lys Asp Tyr Arg Tyr Thr Tyr Asp Lys Tyr Phe Leu 
705                 710                 715                 720 


His Met Pro Ile Thr Ile Asn Phe Lys Ala Asn Lys Thr Ser Phe Ile 
                725                 730                 735     


Asn Asp Arg Ile Leu Gln Tyr Ile Ala Lys Glu Lys Asp Leu His Val 
            740                 745                 750         


Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Ile Tyr Val Ser Val Ile 
        755                 760                 765             


Asp Thr Cys Gly Asn Ile Val Glu Gln Lys Ser Phe Asn Ile Val Asn 
    770                 775                 780                 


Gly Tyr Asp Tyr Gln Ile Lys Leu Lys Gln Gln Glu Gly Ala Arg Gln 
785                 790                 795                 800 


Ile Ala Arg Lys Glu Trp Lys Glu Ile Gly Lys Ile Lys Glu Ile Lys 
                805                 810                 815     


Glu Gly Tyr Leu Ser Leu Val Ile His Glu Ile Ser Lys Met Val Ile 
            820                 825                 830         


Lys Tyr Asn Ala Ile Ile Ala Met Glu Asp Leu Ser Tyr Gly Phe Lys 
        835                 840                 845             


Lys Gly Arg Phe Lys Val Glu Arg Gln Val Tyr Gln Lys Phe Glu Thr 
    850                 855                 860                 


Met Leu Ile Asn Lys Leu Asn Tyr Leu Val Phe Lys Asp Ile Ser Ile 
865                 870                 875                 880 


Thr Glu Asn Gly Gly Leu Leu Lys Gly Tyr Gln Leu Thr Tyr Ile Pro 
                885                 890                 895     


Asp Lys Leu Lys Asn Val Gly His Gln Cys Gly Cys Ile Phe Tyr Val 
            900                 905                 910         


Pro Ala Ala Tyr Thr Ser Lys Ile Asp Pro Thr Thr Gly Phe Val Asn 
        915                 920                 925             


Ile Phe Lys Phe Lys Asp Leu Thr Val Asp Ala Lys Arg Glu Phe Ile 
    930                 935                 940                 


Lys Lys Phe Asp Ser Ile Arg Tyr Asp Ser Asp Lys Asn Leu Phe Cys 
945                 950                 955                 960 


Phe Thr Phe Asp Tyr Asn Asn Phe Ile Thr Gln Asn Thr Val Met Ser 
                965                 970                 975     


Lys Ser Ser Trp Ser Val Tyr Thr Tyr Gly Val Arg Ile Lys Arg Arg 
            980                 985                 990         


Phe Val Asn Gly Arg Phe Ser Asn  Glu Ser Asp Thr Ile  Asp Ile Thr 
        995                 1000                 1005             


Lys Asp  Met Glu Lys Thr Leu  Glu Met Thr Asp Ile  Asn Trp Arg 
    1010                 1015                 1020             


Asp Gly  His Asp Leu Arg Gln  Asp Ile Ile Asp Tyr  Glu Ile Val 
    1025                 1030                 1035             


Gln His  Ile Phe Glu Ile Phe  Lys Leu Thr Val Gln  Met Arg Asn 
    1040                 1045                 1050             


Ser Leu  Ser Glu Leu Glu Asp  Arg Asp Tyr Asp Arg  Leu Ile Ser 
    1055                 1060                 1065             


Pro Val  Leu Asn Glu Asn Asn  Ile Phe Tyr Asp Ser  Ala Lys Ala 
    1070                 1075                 1080             


Gly Asp  Ala Leu Pro Lys Asp  Ala Asp Ala Asn Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Ile Ala  Leu Lys Gly Leu Tyr  Glu Ile Lys Gln Ile  Thr Glu Asn 
    1100                 1105                 1110             


Trp Lys  Glu Asp Gly Lys Phe  Ser Arg Asp Lys Leu  Lys Ile Ser 
    1115                 1120                 1125             


Asn Lys  Asp Trp Phe Asp Phe  Ile Gln Asn Lys Arg  Tyr Leu 
    1130                 1135                 1140         


<210>  125
<211>  1259
<212>  PRT
<213>  Unknown

<220>
<223>  Clostridium sp. AF34-10BH

<400>  125

Met Asn Tyr Lys Thr Gly Leu Glu Asp Phe Ile Gly Lys Glu Ser Leu 
1               5                   10                  15      


Ser Lys Thr Leu Arg Asn Ala Leu Ile Pro Thr Glu Ser Thr Lys Ile 
            20                  25                  30          


His Met Glu Glu Met Gly Val Ile Arg Asp Asp Glu Leu Arg Ala Glu 
        35                  40                  45              


Lys Gln Gln Glu Leu Lys Glu Ile Met Asp Asp Tyr Tyr Arg Ala Phe 
    50                  55                  60                  


Ile Glu Glu Lys Leu Gly Gln Ile Gln Gly Ile Gln Trp Asn Ser Leu 
65                  70                  75                  80  


Phe Gln Lys Met Glu Glu Thr Met Glu Asp Ile Ser Val Arg Lys Asp 
                85                  90                  95      


Leu Asp Lys Ile Gln Asn Glu Lys Arg Lys Glu Ile Cys Cys Tyr Phe 
            100                 105                 110         


Thr Ser Asp Lys Arg Phe Lys Asp Leu Phe Asn Ala Lys Leu Ile Thr 
        115                 120                 125             


Asp Ile Leu Pro Asn Phe Ile Lys Asp Asn Lys Glu Tyr Thr Glu Glu 
    130                 135                 140                 


Glu Lys Ala Glu Lys Glu Gln Thr Arg Val Leu Phe Gln Arg Phe Ala 
145                 150                 155                 160 


Thr Ala Phe Thr Asn Tyr Phe Asn Gln Arg Arg Asn Asn Phe Ser Glu 
                165                 170                 175     


Asp Asn Ile Ser Thr Ala Ile Ser Phe Arg Ile Val Asn Glu Asn Ser 
            180                 185                 190         


Glu Ile His Leu Gln Asn Met Arg Ala Phe Gln Arg Ile Glu Gln Gln 
        195                 200                 205             


Tyr Pro Glu Glu Val Cys Gly Met Glu Glu Glu Tyr Lys Asp Met Leu 
    210                 215                 220                 


Gln Glu Trp Gln Met Lys His Ile Tyr Leu Val Asp Phe Tyr Asp Arg 
225                 230                 235                 240 


Val Leu Thr Gln Pro Gly Ile Glu Tyr Tyr Asn Gly Ile Cys Gly Lys 
                245                 250                 255     


Ile Asn Glu His Met Asn Gln Phe Cys Gln Lys Asn Arg Ile Asn Lys 
            260                 265                 270         


Asn Asp Phe Arg Met Lys Lys Leu His Lys Gln Ile Leu Cys Lys Lys 
        275                 280                 285             


Ser Ser Tyr Tyr Glu Ile Pro Phe Arg Phe Glu Ser Asp Gln Glu Val 
    290                 295                 300                 


Tyr Asp Ala Leu Asn Glu Phe Ile Lys Thr Met Lys Glu Lys Glu Ile 
305                 310                 315                 320 


Ile Cys Arg Cys Val His Leu Gly Gln Lys Cys Asp Asp Tyr Asp Leu 
                325                 330                 335     


Gly Lys Ile Tyr Ile Ser Ser Asn Lys Tyr Glu Gln Ile Ser Asn Ala 
            340                 345                 350         


Leu Tyr Gly Ser Trp Asp Thr Ile Arg Lys Cys Ile Lys Glu Glu Tyr 
        355                 360                 365             


Met Asp Ala Leu Pro Gly Lys Gly Glu Lys Lys Glu Glu Lys Ala Glu 
    370                 375                 380                 


Ala Ala Ala Lys Lys Glu Glu Tyr Arg Ser Ile Ala Asp Ile Asp Lys 
385                 390                 395                 400 


Ile Ile Ser Leu Tyr Gly Ser Glu Met Asp Arg Thr Ile Ser Ala Lys 
                405                 410                 415     


Lys Cys Ile Thr Glu Ile Cys Asp Met Ala Gly Gln Ile Ser Thr Asp 
            420                 425                 430         


Pro Leu Val Cys Asn Ser Asp Ile Lys Leu Leu Gln Asn Lys Glu Lys 
        435                 440                 445             


Thr Thr Glu Ile Lys Thr Ile Leu Asp Ser Phe Leu His Val Tyr Gln 
    450                 455                 460                 


Trp Gly Gln Thr Phe Ile Val Ser Asp Ile Ile Glu Lys Asp Ser Tyr 
465                 470                 475                 480 


Phe Tyr Ser Glu Leu Glu Asp Val Leu Glu Asp Phe Glu Gly Ile Thr 
                485                 490                 495     


Thr Leu Tyr Asn His Val Arg Ser Tyr Val Thr Gln Lys Pro Tyr Ser 
            500                 505                 510         


Thr Val Lys Phe Lys Leu His Phe Gly Ser Pro Thr Leu Ala Asn Gly 
        515                 520                 525             


Trp Ser Gln Ser Lys Glu Tyr Asp Asn Asn Ala Ile Leu Leu Met Arg 
    530                 535                 540                 


Asp Gln Lys Phe Tyr Leu Gly Ile Phe Asn Val Arg Asn Lys Pro Asp 
545                 550                 555                 560 


Lys Gln Ile Ile Lys Gly His Glu Lys Glu Glu Lys Gly Asp Tyr Lys 
                565                 570                 575     


Lys Met Ile Tyr Asn Leu Leu Pro Gly Pro Ser Lys Met Leu Pro Lys 
            580                 585                 590         


Val Phe Ile Thr Ser Arg Ser Gly Gln Glu Thr Tyr Lys Pro Ser Lys 
        595                 600                 605             


His Ile Leu Asp Gly Tyr Asn Glu Lys Arg His Ile Lys Ser Ser Pro 
    610                 615                 620                 


Lys Phe Asp Leu Gly Tyr Cys Trp Asp Leu Ile Asp Tyr Tyr Lys Glu 
625                 630                 635                 640 


Cys Ile His Lys His Pro Asp Trp Lys Asn Tyr Asp Phe His Phe Ser 
                645                 650                 655     


Asp Thr Lys Asp Tyr Glu Asp Ile Ser Gly Phe Tyr Arg Glu Val Glu 
            660                 665                 670         


Met Gln Gly Tyr Gln Ile Lys Trp Thr Tyr Ile Ser Ala Asp Glu Ile 
        675                 680                 685             


Gln Lys Leu Asp Glu Lys Gly Gln Ile Phe Leu Phe Gln Ile Tyr Asn 
    690                 695                 700                 


Lys Asp Phe Ser Val His Ser Thr Gly Lys Asp Asn Leu His Thr Met 
705                 710                 715                 720 


Tyr Leu Lys Asn Leu Phe Ser Glu Glu Asn Leu Lys Asp Ile Val Leu 
                725                 730                 735     


Lys Leu Asn Gly Glu Ala Glu Leu Phe Phe Arg Lys Ala Ser Ile Lys 
            740                 745                 750         


Thr Pro Val Val His Lys Lys Gly Ser Val Leu Val Asn Arg Ser Tyr 
        755                 760                 765             


Thr Gln Thr Val Gly Asp Lys Glu Ile Arg Val Ser Ile Pro Glu Glu 
    770                 775                 780                 


Tyr Tyr Thr Glu Ile Tyr Asn Tyr Leu Asn His Ile Gly Arg Gly Lys 
785                 790                 795                 800 


Leu Ser Thr Glu Ala Gln Arg Tyr Leu Glu Glu Arg Lys Ile Lys Ser 
                805                 810                 815     


Phe Thr Ala Thr Lys Asp Ile Val Lys Asn Tyr Arg Tyr Cys Cys Asp 
            820                 825                 830         


His Tyr Phe Leu His Leu Pro Ile Thr Ile Asn Phe Lys Ala Lys Ser 
        835                 840                 845             


Asp Ile Ala Val Asn Glu Arg Thr Leu Ala Tyr Ile Ala Lys Lys Glu 
    850                 855                 860                 


Asp Ile His Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr 
865                 870                 875                 880 


Ile Ser Val Val Asp Val His Gly Asn Ile Arg Glu Gln Arg Ser Phe 
                885                 890                 895     


Asn Ile Val Asn Gly Tyr Asp Tyr Gln Gln Lys Leu Lys Asp Arg Glu 
            900                 905                 910         


Lys Ser Arg Asp Ala Ala Arg Lys Asn Trp Glu Glu Ile Glu Lys Ile 
        915                 920                 925             


Lys Glu Leu Lys Glu Gly Tyr Leu Ser Met Val Ile His Tyr Ile Ala 
    930                 935                 940                 


Gln Leu Val Val Lys Tyr Asn Ala Val Val Ala Met Glu Asp Leu Asn 
945                 950                 955                 960 


Tyr Gly Phe Lys Thr Gly Arg Phe Lys Val Glu Arg Gln Val Tyr Gln 
                965                 970                 975     


Lys Phe Glu Thr Met Leu Ile Glu Lys Leu His Tyr Leu Val Phe Lys 
            980                 985                 990         


Asp Arg Glu Val Cys Glu Glu Gly  Gly Val Leu Arg Gly  Tyr Gln Leu 
        995                 1000                 1005             


Thr Tyr  Ile Pro Glu Ser Leu  Lys Lys Val Gly Lys  Gln Cys Gly 
    1010                 1015                 1020             


Phe Ile  Phe Tyr Val Pro Ala  Gly Tyr Thr Ser Lys  Ile Asp Pro 
    1025                 1030                 1035             


Thr Thr  Gly Phe Val Asn Leu  Phe Ser Phe Lys Asn  Leu Thr Asn 
    1040                 1045                 1050             


Arg Glu  Ser Arg Gln Asp Phe  Val Gly Lys Phe Asp  Glu Ile Arg 
    1055                 1060                 1065             


Tyr Asp  Arg Asp Lys Lys Met  Phe Glu Phe Ser Phe  Asp Tyr Asn 
    1070                 1075                 1080             


Asn Tyr  Ile Lys Lys Gly Thr  Met Leu Ala Ser Thr  Lys Trp Lys 
    1085                 1090                 1095             


Val Tyr  Thr Asn Gly Thr Arg  Leu Lys Arg Ile Val  Val Asn Gly 
    1100                 1105                 1110             


Lys Tyr  Thr Ser Gln Ser Met  Glu Val Glu Leu Thr  Asp Ala Met 
    1115                 1120                 1125             


Glu Lys  Met Leu Gln Arg Ala  Gly Ile Glu Tyr His  Asp Gly Lys 
    1130                 1135                 1140             


Asp Leu  Lys Gly Gln Ile Val  Glu Lys Gly Ile Glu  Ala Glu Ile 
    1145                 1150                 1155             


Ile Asp  Ile Phe Arg Leu Thr  Val Gln Met Arg Asn  Ser Arg Ser 
    1160                 1165                 1170             


Glu Ser  Glu Asp Arg Glu Tyr  Asp Arg Leu Ile Ser  Pro Val Leu 
    1175                 1180                 1185             


Asn Asp  Lys Gly Glu Phe Phe  Asp Thr Ala Thr Ala  Asp Lys Thr 
    1190                 1195                 1200             


Leu Pro  Gln Asp Ala Asp Ala  Asn Gly Ala Tyr Cys  Ile Ala Leu 
    1205                 1210                 1215             


Lys Gly  Leu Tyr Glu Val Lys  Gln Ile Lys Glu Asn  Trp Lys Glu 
    1220                 1225                 1230             


Asn Glu  Gln Phe Pro Arg Asn  Lys Leu Val Gln Asp  Asn Lys Thr 
    1235                 1240                 1245             


Trp Phe  Asp Phe Met Gln Lys  Lys Arg Tyr Leu 
    1250                 1255                 


<210>  126
<211>  1108
<212>  PRT
<213>  Bacillus hisashii

<400>  126

Met Ala Thr Arg Ser Phe Ile Leu Lys Ile Glu Pro Asn Glu Glu Val 
1               5                   10                  15      


Lys Lys Gly Leu Trp Lys Thr His Glu Val Leu Asn His Gly Ile Ala 
            20                  25                  30          


Tyr Tyr Met Asn Ile Leu Lys Leu Ile Arg Gln Glu Ala Ile Tyr Glu 
        35                  40                  45              


His His Glu Gln Asp Pro Lys Asn Pro Lys Lys Val Ser Lys Ala Glu 
    50                  55                  60                  


Ile Gln Ala Glu Leu Trp Asp Phe Val Leu Lys Met Gln Lys Cys Asn 
65                  70                  75                  80  


Ser Phe Thr His Glu Val Asp Lys Asp Glu Val Phe Asn Ile Leu Arg 
                85                  90                  95      


Glu Leu Tyr Glu Glu Leu Val Pro Ser Ser Val Glu Lys Lys Gly Glu 
            100                 105                 110         


Ala Asn Gln Leu Ser Asn Lys Phe Leu Tyr Pro Leu Val Asp Pro Asn 
        115                 120                 125             


Ser Gln Ser Gly Lys Gly Thr Ala Ser Ser Gly Arg Lys Pro Arg Trp 
    130                 135                 140                 


Tyr Asn Leu Lys Ile Ala Gly Asp Pro Ser Trp Glu Glu Glu Lys Lys 
145                 150                 155                 160 


Lys Trp Glu Glu Asp Lys Lys Lys Asp Pro Leu Ala Lys Ile Leu Gly 
                165                 170                 175     


Lys Leu Ala Glu Tyr Gly Leu Ile Pro Leu Phe Ile Pro Tyr Thr Asp 
            180                 185                 190         


Ser Asn Glu Pro Ile Val Lys Glu Ile Lys Trp Met Glu Lys Ser Arg 
        195                 200                 205             


Asn Gln Ser Val Arg Arg Leu Asp Lys Asp Met Phe Ile Gln Ala Leu 
    210                 215                 220                 


Glu Arg Phe Leu Ser Trp Glu Ser Trp Asn Leu Lys Val Lys Glu Glu 
225                 230                 235                 240 


Tyr Glu Lys Val Glu Lys Glu Tyr Lys Thr Leu Glu Glu Arg Ile Lys 
                245                 250                 255     


Glu Asp Ile Gln Ala Leu Lys Ala Leu Glu Gln Tyr Glu Lys Glu Arg 
            260                 265                 270         


Gln Glu Gln Leu Leu Arg Asp Thr Leu Asn Thr Asn Glu Tyr Arg Leu 
        275                 280                 285             


Ser Lys Arg Gly Leu Arg Gly Trp Arg Glu Ile Ile Gln Lys Trp Leu 
    290                 295                 300                 


Lys Met Asp Glu Asn Glu Pro Ser Glu Lys Tyr Leu Glu Val Phe Lys 
305                 310                 315                 320 


Asp Tyr Gln Arg Lys His Pro Arg Glu Ala Gly Asp Tyr Ser Val Tyr 
                325                 330                 335     


Glu Phe Leu Ser Lys Lys Glu Asn His Phe Ile Trp Arg Asn His Pro 
            340                 345                 350         


Glu Tyr Pro Tyr Leu Tyr Ala Thr Phe Cys Glu Ile Asp Lys Lys Lys 
        355                 360                 365             


Lys Asp Ala Lys Gln Gln Ala Thr Phe Thr Leu Ala Asp Pro Ile Asn 
    370                 375                 380                 


His Pro Leu Trp Val Arg Phe Glu Glu Arg Ser Gly Ser Asn Leu Asn 
385                 390                 395                 400 


Lys Tyr Arg Ile Leu Thr Glu Gln Leu His Thr Glu Lys Leu Lys Lys 
                405                 410                 415     


Lys Leu Thr Val Gln Leu Asp Arg Leu Ile Tyr Pro Thr Glu Ser Gly 
            420                 425                 430         


Gly Trp Glu Glu Lys Gly Lys Val Asp Ile Val Leu Leu Pro Ser Arg 
        435                 440                 445             


Gln Phe Tyr Asn Gln Ile Phe Leu Asp Ile Glu Glu Lys Gly Lys His 
    450                 455                 460                 


Ala Phe Thr Tyr Lys Asp Glu Ser Ile Lys Phe Pro Leu Lys Gly Thr 
465                 470                 475                 480 


Leu Gly Gly Ala Arg Val Gln Phe Asp Arg Asp His Leu Arg Arg Tyr 
                485                 490                 495     


Pro His Lys Val Glu Ser Gly Asn Val Gly Arg Ile Tyr Phe Asn Met 
            500                 505                 510         


Thr Val Asn Ile Glu Pro Thr Glu Ser Pro Val Ser Lys Ser Leu Lys 
        515                 520                 525             


Ile His Arg Asp Asp Phe Pro Lys Val Val Asn Phe Lys Pro Lys Glu 
    530                 535                 540                 


Leu Thr Glu Trp Ile Lys Asp Ser Lys Gly Lys Lys Leu Lys Ser Gly 
545                 550                 555                 560 


Ile Glu Ser Leu Glu Ile Gly Leu Arg Val Met Ser Ile Asp Leu Gly 
                565                 570                 575     


Gln Arg Gln Ala Ala Ala Ala Ser Ile Phe Glu Val Val Asp Gln Lys 
            580                 585                 590         


Pro Asp Ile Glu Gly Lys Leu Phe Phe Pro Ile Lys Gly Thr Glu Leu 
        595                 600                 605             


Tyr Ala Val His Arg Ala Ser Phe Asn Ile Lys Leu Pro Gly Glu Thr 
    610                 615                 620                 


Leu Val Lys Ser Arg Glu Val Leu Arg Lys Ala Arg Glu Asp Asn Leu 
625                 630                 635                 640 


Lys Leu Met Asn Gln Lys Leu Asn Phe Leu Arg Asn Val Leu His Phe 
                645                 650                 655     


Gln Gln Phe Glu Asp Ile Thr Glu Arg Glu Lys Arg Val Thr Lys Trp 
            660                 665                 670         


Ile Ser Arg Gln Glu Asn Ser Asp Val Pro Leu Val Tyr Gln Asp Glu 
        675                 680                 685             


Leu Ile Gln Ile Arg Glu Leu Met Tyr Lys Pro Tyr Lys Asp Trp Val 
    690                 695                 700                 


Ala Phe Leu Lys Gln Leu His Lys Arg Leu Glu Val Glu Ile Gly Lys 
705                 710                 715                 720 


Glu Val Lys His Trp Arg Lys Ser Leu Ser Asp Gly Arg Lys Gly Leu 
                725                 730                 735     


Tyr Gly Ile Ser Leu Lys Asn Ile Asp Glu Ile Asp Arg Thr Arg Lys 
            740                 745                 750         


Phe Leu Leu Arg Trp Ser Leu Arg Pro Thr Glu Pro Gly Glu Val Arg 
        755                 760                 765             


Arg Leu Glu Pro Gly Gln Arg Phe Ala Ile Asp Gln Leu Asn His Leu 
    770                 775                 780                 


Asn Ala Leu Lys Glu Asp Arg Leu Lys Lys Met Ala Asn Thr Ile Ile 
785                 790                 795                 800 


Met His Ala Leu Gly Tyr Cys Tyr Asp Val Arg Lys Lys Lys Trp Gln 
                805                 810                 815     


Ala Lys Asn Pro Ala Cys Gln Ile Ile Leu Phe Glu Asp Leu Ser Asn 
            820                 825                 830         


Tyr Asn Pro Tyr Glu Glu Arg Ser Arg Phe Glu Asn Ser Lys Leu Met 
        835                 840                 845             


Lys Trp Ser Arg Arg Glu Ile Pro Arg Gln Val Ala Leu Gln Gly Glu 
    850                 855                 860                 


Ile Tyr Gly Leu Gln Val Gly Glu Val Gly Ala Gln Phe Ser Ser Arg 
865                 870                 875                 880 


Phe His Ala Lys Thr Gly Ser Pro Gly Ile Arg Cys Ser Val Val Thr 
                885                 890                 895     


Lys Glu Lys Leu Gln Asp Asn Arg Phe Phe Lys Asn Leu Gln Arg Glu 
            900                 905                 910         


Gly Arg Leu Thr Leu Asp Lys Ile Ala Val Leu Lys Glu Gly Asp Leu 
        915                 920                 925             


Tyr Pro Asp Lys Gly Gly Glu Lys Phe Ile Ser Leu Ser Lys Asp Arg 
    930                 935                 940                 


Lys Cys Val Thr Thr His Ala Asp Ile Asn Ala Ala Gln Asn Leu Gln 
945                 950                 955                 960 


Lys Arg Phe Trp Thr Arg Thr His Gly Phe Tyr Lys Val Tyr Cys Lys 
                965                 970                 975     


Ala Tyr Gln Val Asp Gly Gln Thr Val Tyr Ile Pro Glu Ser Lys Asp 
            980                 985                 990         


Gln Lys Gln Lys Ile Ile Glu Glu  Phe Gly Glu Gly Tyr  Phe Ile Leu 
        995                 1000                 1005             


Lys Asp  Gly Val Tyr Glu Trp  Val Asn Ala Gly Lys  Leu Lys Ile 
    1010                 1015                 1020             


Lys Lys  Gly Ser Ser Lys Gln  Ser Ser Ser Glu Leu  Val Asp Ser 
    1025                 1030                 1035             


Asp Ile  Leu Lys Asp Ser Phe  Asp Leu Ala Ser Glu  Leu Lys Gly 
    1040                 1045                 1050             


Glu Lys  Leu Met Leu Tyr Arg  Asp Pro Ser Gly Asn  Val Phe Pro 
    1055                 1060                 1065             


Ser Asp  Lys Trp Met Ala Ala  Gly Val Phe Phe Gly  Lys Leu Glu 
    1070                 1075                 1080             


Arg Ile  Leu Ile Ser Lys Leu  Thr Asn Gln Tyr Ser  Ile Ser Thr 
    1085                 1090                 1095             


Ile Glu  Asp Asp Ser Ser Lys  Gln Ser Met 
    1100                 1105             


<210>  127
<211>  1465
<212>  PRT
<213>  Thermomonas hydrothermalis

<400>  127

Met Ser Glu Lys Thr Thr Gln Arg Ala Tyr Thr Leu Arg Leu Asn Arg 
1               5                   10                  15      


Ala Ser Gly Glu Cys Ala Val Cys Gln Asn Asn Ser Cys Asp Cys Trp 
            20                  25                  30          


His Asp Ala Leu Trp Ala Thr His Lys Ala Val Asn Arg Gly Ala Lys 
        35                  40                  45              


Ala Phe Gly Asp Trp Leu Leu Thr Leu Arg Gly Gly Leu Cys His Thr 
    50                  55                  60                  


Leu Val Glu Met Glu Val Pro Ala Lys Gly Asn Asn Pro Pro Gln Arg 
65                  70                  75                  80  


Pro Thr Asp Gln Glu Arg Arg Asp Arg Arg Val Leu Leu Ala Leu Ser 
                85                  90                  95      


Trp Leu Ser Val Glu Asp Glu His Gly Ala Pro Lys Glu Phe Ile Val 
            100                 105                 110         


Ala Thr Gly Arg Asp Ser Ala Asp Asp Arg Ala Lys Lys Val Glu Glu 
        115                 120                 125             


Lys Leu Arg Glu Ile Leu Glu Lys Arg Asp Phe Gln Glu His Glu Ile 
    130                 135                 140                 


Asp Ala Trp Leu Gln Asp Cys Gly Pro Ser Leu Lys Ala His Ile Arg 
145                 150                 155                 160 


Glu Asp Ala Val Trp Val Asn Arg Arg Ala Leu Phe Asp Ala Ala Val 
                165                 170                 175     


Glu Arg Ile Lys Thr Leu Thr Trp Glu Glu Ala Trp Asp Phe Leu Glu 
            180                 185                 190         


Pro Phe Phe Gly Thr Gln Tyr Phe Ala Gly Ile Gly Asp Gly Lys Asp 
        195                 200                 205             


Lys Asp Asp Ala Glu Gly Pro Ala Arg Gln Gly Glu Lys Ala Lys Asp 
    210                 215                 220                 


Leu Val Gln Lys Ala Gly Gln Trp Leu Ser Ala Arg Phe Gly Ile Gly 
225                 230                 235                 240 


Thr Gly Ala Asp Phe Met Ser Met Ala Glu Ala Tyr Glu Lys Ile Ala 
                245                 250                 255     


Lys Trp Ala Ser Gln Ala Gln Asn Gly Asp Asn Gly Lys Ala Thr Ile 
            260                 265                 270         


Glu Lys Leu Ala Cys Ala Leu Arg Pro Ser Glu Pro Pro Thr Leu Asp 
        275                 280                 285             


Thr Val Leu Lys Cys Ile Ser Gly Pro Gly His Lys Ser Ala Thr Arg 
    290                 295                 300                 


Glu Tyr Leu Lys Thr Leu Asp Lys Lys Ser Thr Val Thr Gln Glu Asp 
305                 310                 315                 320 


Leu Asn Gln Leu Arg Lys Leu Ala Asp Glu Asp Ala Arg Asn Cys Arg 
                325                 330                 335     


Lys Lys Val Gly Lys Lys Gly Lys Lys Pro Trp Ala Asp Glu Val Leu 
            340                 345                 350         


Lys Asp Val Glu Asn Ser Cys Glu Leu Thr Tyr Leu Gln Asp Asn Ser 
        355                 360                 365             


Pro Ala Arg His Arg Glu Phe Ser Val Met Leu Asp His Ala Ala Arg 
    370                 375                 380                 


Arg Val Ser Met Ala His Ser Trp Ile Lys Lys Ala Glu Gln Arg Arg 
385                 390                 395                 400 


Arg Gln Phe Glu Ser Asp Ala Gln Lys Leu Lys Asn Leu Gln Glu Arg 
                405                 410                 415     


Ala Pro Ser Ala Val Glu Trp Leu Asp Arg Phe Cys Glu Ser Arg Ser 
            420                 425                 430         


Met Thr Thr Gly Ala Asn Thr Gly Ser Gly Tyr Arg Ile Arg Lys Arg 
        435                 440                 445             


Ala Ile Glu Gly Trp Ser Tyr Val Val Gln Ala Trp Ala Glu Ala Ser 
    450                 455                 460                 


Cys Asp Thr Glu Asp Lys Arg Ile Ala Ala Ala Arg Lys Val Gln Ala 
465                 470                 475                 480 


Asp Pro Glu Ile Glu Lys Phe Gly Asp Ile Gln Leu Phe Glu Ala Leu 
                485                 490                 495     


Ala Ala Asp Glu Ala Ile Cys Val Trp Arg Asp Gln Glu Gly Thr Gln 
            500                 505                 510         


Asn Pro Ser Ile Leu Ile Asp Tyr Val Thr Gly Lys Thr Ala Glu His 
        515                 520                 525             


Asn Gln Lys Arg Phe Lys Val Pro Ala Tyr Arg His Pro Asp Glu Leu 
    530                 535                 540                 


Arg His Pro Val Phe Cys Asp Phe Gly Asn Ser Arg Trp Ser Ile Gln 
545                 550                 555                 560 


Phe Ala Ile His Lys Glu Ile Arg Asp Arg Asp Lys Gly Ala Lys Gln 
                565                 570                 575     


Asp Thr Arg Gln Leu Gln Asn Arg His Gly Leu Lys Met Arg Leu Trp 
            580                 585                 590         


Asn Gly Arg Ser Met Thr Asp Val Asn Leu His Trp Ser Ser Lys Arg 
        595                 600                 605             


Leu Thr Ala Asp Leu Ala Leu Asp Gln Asn Pro Asn Pro Asn Pro Thr 
    610                 615                 620                 


Glu Val Thr Arg Ala Asp Arg Leu Gly Arg Ala Ala Ser Ser Ala Phe 
625                 630                 635                 640 


Asp His Val Lys Ile Lys Asn Val Phe Asn Glu Lys Glu Trp Asn Gly 
                645                 650                 655     


Arg Leu Gln Ala Pro Arg Ala Glu Leu Asp Arg Ile Ala Lys Leu Glu 
            660                 665                 670         


Glu Gln Gly Lys Thr Glu Gln Ala Glu Lys Leu Arg Lys Arg Leu Arg 
        675                 680                 685             


Trp Tyr Val Ser Phe Ser Pro Cys Leu Ser Pro Ser Gly Pro Phe Ile 
    690                 695                 700                 


Val Tyr Ala Gly Gln His Asn Ile Gln Pro Lys Arg Ser Gly Gln Tyr 
705                 710                 715                 720 


Ala Pro His Ala Gln Ala Asn Lys Gly Arg Ala Arg Leu Ala Gln Leu 
                725                 730                 735     


Ile Leu Ser Arg Leu Pro Asp Leu Arg Ile Leu Ser Val Asp Leu Gly 
            740                 745                 750         


His Arg Phe Ala Ala Ala Cys Ala Val Trp Glu Thr Leu Ser Ser Asp 
        755                 760                 765             


Ala Phe Arg Arg Glu Ile Gln Gly Leu Asn Val Leu Ala Gly Gly Ser 
    770                 775                 780                 


Gly Glu Gly Asp Leu Phe Leu His Val Glu Met Thr Gly Asp Asp Gly 
785                 790                 795                 800 


Lys Arg Arg Thr Val Val Tyr Arg Arg Ile Gly Pro Asp Gln Leu Leu 
                805                 810                 815     


Asp Asn Thr Pro His Pro Ala Pro Trp Ala Arg Leu Asp Arg Gln Phe 
            820                 825                 830         


Leu Ile Lys Leu Gln Gly Glu Asp Glu Gly Val Arg Glu Ala Ser Asn 
        835                 840                 845             


Glu Glu Leu Trp Thr Val His Lys Leu Glu Val Glu Val Gly Arg Thr 
    850                 855                 860                 


Val Pro Leu Ile Asp Arg Met Val Arg Ser Gly Phe Gly Lys Thr Glu 
865                 870                 875                 880 


Lys Gln Lys Glu Arg Leu Lys Lys Leu Arg Glu Leu Gly Trp Ile Ser 
                885                 890                 895     


Ala Met Pro Asn Glu Pro Ser Ala Glu Thr Asp Glu Lys Glu Gly Glu 
            900                 905                 910         


Ile Arg Ser Ile Ser Arg Ser Val Asp Glu Leu Met Ser Ser Ala Leu 
        915                 920                 925             


Gly Thr Leu Arg Leu Ala Leu Lys Arg His Gly Asn Arg Ala Arg Ile 
    930                 935                 940                 


Ala Phe Ala Met Thr Ala Asp Tyr Lys Pro Met Pro Gly Gly Gln Lys 
945                 950                 955                 960 


Tyr Tyr Phe His Glu Ala Lys Glu Ala Ser Lys Asn Asp Asp Glu Thr 
                965                 970                 975     


Lys Arg Arg Asp Asn Gln Ile Glu Phe Leu Gln Asp Ala Leu Ser Leu 
            980                 985                 990         


Trp His Asp Leu Phe Ser Ser Pro  Asp Trp Glu Asp Asn  Glu Ala Lys 
        995                 1000                 1005             


Lys Leu  Trp Gln Asn His Ile  Ala Thr Leu Pro Asn  Tyr Gln Thr 
    1010                 1015                 1020             


Pro Glu  Glu Ile Ser Ala Glu  Leu Lys Arg Val Glu  Arg Asn Lys 
    1025                 1030                 1035             


Lys Arg  Lys Glu Asn Arg Asp  Lys Leu Arg Thr Ala  Ala Lys Ala 
    1040                 1045                 1050             


Leu Ala  Glu Asn Asp Gln Leu  Arg Gln His Leu His  Asp Thr Trp 
    1055                 1060                 1065             


Lys Glu  Arg Trp Glu Ser Asp  Asp Gln Gln Trp Lys  Glu Arg Leu 
    1070                 1075                 1080             


Arg Ser  Leu Lys Asp Trp Ile  Phe Pro Arg Gly Lys  Ala Glu Asp 
    1085                 1090                 1095             


Asn Pro  Ser Ile Arg His Val  Gly Gly Leu Ser Ile  Thr Arg Ile 
    1100                 1105                 1110             


Asn Thr  Ile Ser Gly Leu Tyr  Gln Ile Leu Lys Ala  Phe Lys Met 
    1115                 1120                 1125             


Arg Pro  Glu Pro Asp Asp Leu  Arg Lys Asn Ile Pro  Gln Lys Gly 
    1130                 1135                 1140             


Asp Asp  Glu Leu Glu Asn Phe  Asn Arg Arg Leu Leu  Glu Ala Arg 
    1145                 1150                 1155             


Asp Arg  Leu Arg Glu Gln Arg  Val Lys Gln Leu Ala  Ser Arg Ile 
    1160                 1165                 1170             


Ile Glu  Ala Ala Leu Gly Val  Gly Arg Ile Lys Ile  Pro Lys Asn 
    1175                 1180                 1185             


Gly Lys  Leu Pro Lys Arg Pro  Arg Thr Thr Val Asp  Thr Pro Cys 
    1190                 1195                 1200             


His Ala  Val Val Ile Glu Ser  Leu Lys Thr Tyr Arg  Pro Asp Asp 
    1205                 1210                 1215             


Leu Arg  Thr Arg Arg Glu Asn  Arg Gln Leu Met Gln  Trp Ser Ser 
    1220                 1225                 1230             


Ala Lys  Val Arg Lys Tyr Leu  Lys Glu Gly Cys Glu  Leu Tyr Gly 
    1235                 1240                 1245             


Leu His  Phe Leu Glu Val Pro  Ala Asn Tyr Thr Ser  Arg Gln Cys 
    1250                 1255                 1260             


Ser Arg  Thr Gly Leu Pro Gly  Ile Arg Cys Asp Asp  Val Pro Thr 
    1265                 1270                 1275             


Gly Asp  Phe Leu Lys Ala Pro  Trp Trp Arg Arg Ala  Ile Asn Thr 
    1280                 1285                 1290             


Ala Arg  Glu Lys Asn Gly Gly  Asp Ala Lys Asp Arg  Phe Leu Val 
    1295                 1300                 1305             


Asp Leu  Tyr Asp His Leu Asn  Asn Leu Gln Ser Lys  Gly Glu Ala 
    1310                 1315                 1320             


Leu Pro  Ala Thr Val Arg Val  Pro Arg Gln Gly Gly  Asn Leu Phe 
    1325                 1330                 1335             


Ile Ala  Gly Ala Gln Leu Asp  Asp Thr Asn Lys Glu  Arg Arg Ala 
    1340                 1345                 1350             


Ile Gln  Ala Asp Leu Asn Ala  Ala Ala Asn Ile Gly  Leu Arg Ala 
    1355                 1360                 1365             


Leu Leu  Asp Pro Asp Trp Arg  Gly Arg Trp Trp Tyr  Val Pro Cys 
    1370                 1375                 1380             


Lys Asp  Gly Thr Ser Glu Pro  Ala Leu Asp Arg Ile  Glu Gly Ser 
    1385                 1390                 1395             


Thr Ala  Phe Asn Asp Val Arg  Ser Leu Pro Thr Gly  Asp Asn Ser 
    1400                 1405                 1410             


Ser Arg  Arg Ala Pro Arg Glu  Ile Glu Asn Leu Trp  Arg Asp Pro 
    1415                 1420                 1425             


Ser Gly  Asp Ser Leu Glu Ser  Gly Thr Trp Ser Pro  Thr Arg Ala 
    1430                 1435                 1440             


Tyr Trp  Asp Thr Val Gln Ser  Arg Val Ile Glu Leu  Leu Arg Arg 
    1445                 1450                 1455             


His Ala  Gly Leu Pro Thr Ser  
    1460                 1465 


<210>  128
<211>  1091
<212>  PRT
<213>  Laceyella sacchari

<400>  128

Met Ser Ile Arg Ser Phe Lys Leu Lys Leu Lys Thr Lys Ser Gly Val 
1               5                   10                  15      


Asn Ala Glu Gln Leu Arg Arg Gly Leu Trp Arg Thr His Gln Leu Ile 
            20                  25                  30          


Asn Asp Gly Ile Ala Tyr Tyr Met Asn Trp Leu Val Leu Leu Arg Gln 
        35                  40                  45              


Glu Asp Leu Phe Ile Arg Asn Lys Glu Thr Asn Glu Ile Glu Lys Arg 
    50                  55                  60                  


Ser Lys Glu Glu Ile Gln Ala Val Leu Leu Glu Arg Val His Lys Gln 
65                  70                  75                  80  


Gln Gln Arg Asn Gln Trp Ser Gly Glu Val Asp Glu Gln Thr Leu Leu 
                85                  90                  95      


Gln Ala Leu Arg Gln Leu Tyr Glu Glu Ile Val Pro Ser Val Ile Gly 
            100                 105                 110         


Lys Ser Gly Asn Ala Ser Leu Lys Ala Arg Phe Phe Leu Gly Pro Leu 
        115                 120                 125             


Val Asp Pro Asn Asn Lys Thr Thr Lys Asp Val Ser Lys Ser Gly Pro 
    130                 135                 140                 


Thr Pro Lys Trp Lys Lys Met Lys Asp Ala Gly Asp Pro Asn Trp Val 
145                 150                 155                 160 


Gln Glu Tyr Glu Lys Tyr Met Ala Glu Arg Gln Thr Leu Val Arg Leu 
                165                 170                 175     


Glu Glu Met Gly Leu Ile Pro Leu Phe Pro Met Tyr Thr Asp Glu Val 
            180                 185                 190         


Gly Asp Ile His Trp Leu Pro Gln Ala Ser Gly Tyr Thr Arg Thr Trp 
        195                 200                 205             


Asp Arg Asp Met Phe Gln Gln Ala Ile Glu Arg Leu Leu Ser Trp Glu 
    210                 215                 220                 


Ser Trp Asn Arg Arg Val Arg Glu Arg Arg Ala Gln Phe Glu Lys Lys 
225                 230                 235                 240 


Thr His Asp Phe Ala Ser Arg Phe Ser Glu Ser Asp Val Gln Trp Met 
                245                 250                 255     


Asn Lys Leu Arg Glu Tyr Glu Ala Gln Gln Glu Lys Ser Leu Glu Glu 
            260                 265                 270         


Asn Ala Phe Ala Pro Asn Glu Pro Tyr Ala Leu Thr Lys Lys Ala Leu 
        275                 280                 285             


Arg Gly Trp Glu Arg Val Tyr His Ser Trp Met Arg Leu Asp Ser Ala 
    290                 295                 300                 


Ala Ser Glu Glu Ala Tyr Trp Gln Glu Val Ala Thr Cys Gln Thr Ala 
305                 310                 315                 320 


Met Arg Gly Glu Phe Gly Asp Pro Ala Ile Tyr Gln Phe Leu Ala Gln 
                325                 330                 335     


Lys Glu Asn His Asp Ile Trp Arg Gly Tyr Pro Glu Arg Val Ile Asp 
            340                 345                 350         


Phe Ala Glu Leu Asn His Leu Gln Arg Glu Leu Arg Arg Ala Lys Glu 
        355                 360                 365             


Asp Ala Thr Phe Thr Leu Pro Asp Ser Val Asp His Pro Leu Trp Val 
    370                 375                 380                 


Arg Tyr Glu Ala Pro Gly Gly Thr Asn Ile His Gly Tyr Asp Leu Val 
385                 390                 395                 400 


Gln Asp Thr Lys Arg Asn Leu Thr Leu Ile Leu Asp Lys Phe Ile Leu 
                405                 410                 415     


Pro Asp Glu Asn Gly Ser Trp His Glu Val Lys Lys Val Pro Phe Ser 
            420                 425                 430         


Leu Ala Lys Ser Lys Gln Phe His Arg Gln Val Trp Leu Gln Glu Glu 
        435                 440                 445             


Gln Lys Gln Lys Lys Arg Glu Val Val Phe Tyr Asp Tyr Ser Thr Asn 
    450                 455                 460                 


Leu Pro His Leu Gly Thr Leu Ala Gly Ala Lys Leu Gln Trp Asp Arg 
465                 470                 475                 480 


Asn Phe Leu Asn Lys Arg Thr Gln Gln Gln Ile Glu Glu Thr Gly Glu 
                485                 490                 495     


Ile Gly Lys Val Phe Phe Asn Ile Ser Val Asp Val Arg Pro Ala Val 
            500                 505                 510         


Glu Val Lys Asn Gly Arg Leu Gln Asn Gly Leu Gly Lys Ala Leu Thr 
        515                 520                 525             


Val Leu Thr His Pro Asp Gly Thr Lys Ile Val Thr Gly Trp Lys Ala 
    530                 535                 540                 


Glu Gln Leu Glu Lys Trp Val Gly Glu Ser Gly Arg Val Ser Ser Leu 
545                 550                 555                 560 


Gly Leu Asp Ser Leu Ser Glu Gly Leu Arg Val Met Ser Ile Asp Leu 
                565                 570                 575     


Gly Gln Arg Thr Ser Ala Thr Val Ser Val Phe Glu Ile Thr Lys Glu 
            580                 585                 590         


Ala Pro Asp Asn Pro Tyr Lys Phe Phe Tyr Gln Leu Glu Gly Thr Glu 
        595                 600                 605             


Met Phe Ala Val His Gln Arg Ser Phe Leu Leu Ala Leu Pro Gly Glu 
    610                 615                 620                 


Asn Pro Pro Gln Lys Ile Lys Gln Met Arg Glu Ile Arg Trp Lys Glu 
625                 630                 635                 640 


Arg Asn Arg Ile Lys Gln Gln Val Asp Gln Leu Ser Ala Ile Leu Arg 
                645                 650                 655     


Leu His Lys Lys Val Asn Glu Asp Glu Arg Ile Gln Ala Ile Asp Lys 
            660                 665                 670         


Leu Leu Gln Lys Val Ala Ser Trp Gln Leu Asn Glu Glu Ile Ala Thr 
        675                 680                 685             


Ala Trp Asn Gln Ala Leu Ser Gln Leu Tyr Ser Lys Ala Lys Glu Asn 
    690                 695                 700                 


Asp Leu Gln Trp Asn Gln Ala Ile Lys Asn Ala His His Gln Leu Glu 
705                 710                 715                 720 


Pro Val Val Gly Lys Gln Ile Ser Leu Trp Arg Lys Asp Leu Ser Thr 
                725                 730                 735     


Gly Arg Gln Gly Ile Ala Gly Leu Ser Leu Trp Ser Ile Glu Glu Leu 
            740                 745                 750         


Glu Ala Thr Lys Lys Leu Leu Thr Arg Trp Ser Lys Arg Ser Arg Glu 
        755                 760                 765             


Pro Gly Val Val Lys Arg Ile Glu Arg Phe Glu Thr Phe Ala Lys Gln 
    770                 775                 780                 


Ile Gln His His Ile Asn Gln Val Lys Glu Asn Arg Leu Lys Gln Leu 
785                 790                 795                 800 


Ala Asn Leu Ile Val Met Thr Ala Leu Gly Tyr Lys Tyr Asp Gln Glu 
                805                 810                 815     


Gln Lys Lys Trp Ile Glu Val Tyr Pro Ala Cys Gln Val Val Leu Phe 
            820                 825                 830         


Glu Asn Leu Arg Ser Tyr Arg Phe Ser Phe Glu Arg Ser Arg Arg Glu 
        835                 840                 845             


Asn Lys Lys Leu Met Glu Trp Ser His Arg Ser Ile Pro Lys Leu Val 
    850                 855                 860                 


Gln Met Gln Gly Glu Leu Phe Gly Leu Gln Val Ala Asp Val Tyr Ala 
865                 870                 875                 880 


Ala Tyr Ser Ser Arg Tyr His Gly Arg Thr Gly Ala Pro Gly Ile Arg 
                885                 890                 895     


Cys His Ala Leu Thr Glu Ala Asp Leu Arg Asn Glu Thr Asn Ile Ile 
            900                 905                 910         


His Glu Leu Ile Glu Ala Gly Phe Ile Lys Glu Glu His Arg Pro Tyr 
        915                 920                 925             


Leu Gln Gln Gly Asp Leu Val Pro Trp Ser Gly Gly Glu Leu Phe Ala 
    930                 935                 940                 


Thr Leu Gln Lys Pro Tyr Asp Asn Pro Arg Ile Leu Thr Leu His Ala 
945                 950                 955                 960 


Asp Ile Asn Ala Ala Gln Asn Ile Gln Lys Arg Phe Trp His Pro Ser 
                965                 970                 975     


Met Trp Phe Arg Val Asn Cys Glu Ser Val Met Glu Gly Glu Ile Val 
            980                 985                 990         


Thr Tyr Val Pro Lys Asn Lys Thr  Val His Lys Lys Gln  Gly Lys Thr 
        995                 1000                 1005             


Phe Arg  Phe Val Lys Val Glu  Gly Ser Asp Val Tyr  Glu Trp Ala 
    1010                 1015                 1020             


Lys Trp  Ser Lys Asn Arg Asn  Lys Asn Thr Phe Ser  Ser Ile Thr 
    1025                 1030                 1035             


Glu Arg  Lys Pro Pro Ser Ser  Met Ile Leu Phe Arg  Asp Pro Ser 
    1040                 1045                 1050             


Gly Thr  Phe Phe Lys Glu Gln  Glu Trp Val Glu Gln  Lys Thr Phe 
    1055                 1060                 1065             


Trp Gly  Lys Val Gln Ser Met  Ile Gln Ala Tyr Met  Lys Lys Thr 
    1070                 1075                 1080             


Ile Val  Arg Gln Arg Met Glu  Glu 
    1085                 1090     


<210>  129
<211>  1194
<212>  PRT
<213>  Dsulfonatronum thiodismutans

<400>  129

Met Val Leu Gly Arg Lys Asp Asp Thr Ala Glu Leu Arg Arg Ala Leu 
1               5                   10                  15      


Trp Thr Thr His Glu His Val Asn Leu Ala Val Ala Glu Val Glu Arg 
            20                  25                  30          


Val Leu Leu Arg Cys Arg Gly Arg Ser Tyr Trp Thr Leu Asp Arg Arg 
        35                  40                  45              


Gly Asp Pro Val His Val Pro Glu Ser Gln Val Ala Glu Asp Ala Leu 
    50                  55                  60                  


Ala Met Ala Arg Glu Ala Gln Arg Arg Asn Gly Trp Pro Val Val Gly 
65                  70                  75                  80  


Glu Asp Glu Glu Ile Leu Leu Ala Leu Arg Tyr Leu Tyr Glu Gln Ile 
                85                  90                  95      


Val Pro Ser Cys Leu Leu Asp Asp Leu Gly Lys Pro Leu Lys Gly Asp 
            100                 105                 110         


Ala Gln Lys Ile Gly Thr Asn Tyr Ala Gly Pro Leu Phe Asp Ser Asp 
        115                 120                 125             


Thr Cys Arg Arg Asp Glu Gly Lys Asp Val Ala Cys Cys Gly Pro Phe 
    130                 135                 140                 


His Glu Val Ala Gly Lys Tyr Leu Gly Ala Leu Pro Glu Trp Ala Thr 
145                 150                 155                 160 


Pro Ile Ser Lys Gln Glu Phe Asp Gly Lys Asp Ala Ser His Leu Arg 
                165                 170                 175     


Phe Lys Ala Thr Gly Gly Asp Asp Ala Phe Phe Arg Val Ser Ile Glu 
            180                 185                 190         


Lys Ala Asn Ala Trp Tyr Glu Asp Pro Ala Asn Gln Asp Ala Leu Lys 
        195                 200                 205             


Asn Lys Ala Tyr Asn Lys Asp Asp Trp Lys Lys Glu Lys Asp Lys Gly 
    210                 215                 220                 


Ile Ser Ser Trp Ala Val Lys Tyr Ile Gln Lys Gln Leu Gln Leu Gly 
225                 230                 235                 240 


Gln Asp Pro Arg Thr Glu Val Arg Arg Lys Leu Trp Leu Glu Leu Gly 
                245                 250                 255     


Leu Leu Pro Leu Phe Ile Pro Val Phe Asp Lys Thr Met Val Gly Asn 
            260                 265                 270         


Leu Trp Asn Arg Leu Ala Val Arg Leu Ala Leu Ala His Leu Leu Ser 
        275                 280                 285             


Trp Glu Ser Trp Asn His Arg Ala Val Gln Asp Gln Ala Leu Ala Arg 
    290                 295                 300                 


Ala Lys Arg Asp Glu Leu Ala Ala Leu Phe Leu Gly Met Glu Asp Gly 
305                 310                 315                 320 


Phe Ala Gly Leu Arg Glu Tyr Glu Leu Arg Arg Asn Glu Ser Ile Lys 
                325                 330                 335     


Gln His Ala Phe Glu Pro Val Asp Arg Pro Tyr Val Val Ser Gly Arg 
            340                 345                 350         


Ala Leu Arg Ser Trp Thr Arg Val Arg Glu Glu Trp Leu Arg His Gly 
        355                 360                 365             


Asp Thr Gln Glu Ser Arg Lys Asn Ile Cys Asn Arg Leu Gln Asp Arg 
    370                 375                 380                 


Leu Arg Gly Lys Phe Gly Asp Pro Asp Val Phe His Trp Leu Ala Glu 
385                 390                 395                 400 


Asp Gly Gln Glu Ala Leu Trp Lys Glu Arg Asp Cys Val Thr Ser Phe 
                405                 410                 415     


Ser Leu Leu Asn Asp Ala Asp Gly Leu Leu Glu Lys Arg Lys Gly Tyr 
            420                 425                 430         


Ala Leu Met Thr Phe Ala Asp Ala Arg Leu His Pro Arg Trp Ala Met 
        435                 440                 445             


Tyr Glu Ala Pro Gly Gly Ser Asn Leu Arg Thr Tyr Gln Ile Arg Lys 
    450                 455                 460                 


Thr Glu Asn Gly Leu Trp Ala Asp Val Val Leu Leu Ser Pro Arg Asn 
465                 470                 475                 480 


Glu Ser Ala Ala Val Glu Glu Lys Thr Phe Asn Val Arg Leu Ala Pro 
                485                 490                 495     


Ser Gly Gln Leu Ser Asn Val Ser Phe Asp Gln Ile Gln Lys Gly Ser 
            500                 505                 510         


Lys Met Val Gly Arg Cys Arg Tyr Gln Ser Ala Asn Gln Gln Phe Glu 
        515                 520                 525             


Gly Leu Leu Gly Gly Ala Glu Ile Leu Phe Asp Arg Lys Arg Ile Ala 
    530                 535                 540                 


Asn Glu Gln His Gly Ala Thr Asp Leu Ala Ser Lys Pro Gly His Val 
545                 550                 555                 560 


Trp Phe Lys Leu Thr Leu Asp Val Arg Pro Gln Ala Pro Gln Gly Trp 
                565                 570                 575     


Leu Asp Gly Lys Gly Arg Pro Ala Leu Pro Pro Glu Ala Lys His Phe 
            580                 585                 590         


Lys Thr Ala Leu Ser Asn Lys Ser Lys Phe Ala Asp Gln Val Arg Pro 
        595                 600                 605             


Gly Leu Arg Val Leu Ser Val Asp Leu Gly Val Arg Ser Phe Ala Ala 
    610                 615                 620                 


Cys Ser Val Phe Glu Leu Val Arg Gly Gly Pro Asp Gln Gly Thr Tyr 
625                 630                 635                 640 


Phe Pro Ala Ala Asp Gly Arg Thr Val Asp Asp Pro Glu Lys Leu Trp 
                645                 650                 655     


Ala Lys His Glu Arg Ser Phe Lys Ile Thr Leu Pro Gly Glu Asn Pro 
            660                 665                 670         


Ser Arg Lys Glu Glu Ile Ala Arg Arg Ala Ala Met Glu Glu Leu Arg 
        675                 680                 685             


Ser Leu Asn Gly Asp Ile Arg Arg Leu Lys Ala Ile Leu Arg Leu Ser 
    690                 695                 700                 


Val Leu Gln Glu Asp Asp Pro Arg Thr Glu His Leu Arg Leu Phe Met 
705                 710                 715                 720 


Glu Ala Ile Val Asp Asp Pro Ala Lys Ser Ala Leu Asn Ala Glu Leu 
                725                 730                 735     


Phe Lys Gly Phe Gly Asp Asp Arg Phe Arg Ser Thr Pro Asp Leu Trp 
            740                 745                 750         


Lys Gln His Cys His Phe Phe His Asp Lys Ala Glu Lys Val Val Ala 
        755                 760                 765             


Glu Arg Phe Ser Arg Trp Arg Thr Glu Thr Arg Pro Lys Ser Ser Ser 
    770                 775                 780                 


Trp Gln Asp Trp Arg Glu Arg Arg Gly Tyr Ala Gly Gly Lys Ser Tyr 
785                 790                 795                 800 


Trp Ala Val Thr Tyr Leu Glu Ala Val Arg Gly Leu Ile Leu Arg Trp 
                805                 810                 815     


Asn Met Arg Gly Arg Thr Tyr Gly Glu Val Asn Arg Gln Asp Lys Lys 
            820                 825                 830         


Gln Phe Gly Thr Val Ala Ser Ala Leu Leu His His Ile Asn Gln Leu 
        835                 840                 845             


Lys Glu Asp Arg Ile Lys Thr Gly Ala Asp Met Ile Ile Gln Ala Ala 
    850                 855                 860                 


Arg Gly Phe Val Pro Arg Lys Asn Gly Ala Gly Trp Val Gln Val His 
865                 870                 875                 880 


Glu Pro Cys Arg Leu Ile Leu Phe Glu Asp Leu Ala Arg Tyr Arg Phe 
                885                 890                 895     


Arg Thr Asp Arg Ser Arg Arg Glu Asn Ser Arg Leu Met Arg Trp Ser 
            900                 905                 910         


His Arg Glu Ile Val Asn Glu Val Gly Met Gln Gly Glu Leu Tyr Gly 
        915                 920                 925             


Leu His Val Asp Thr Thr Glu Ala Gly Phe Ser Ser Arg Tyr Leu Ala 
    930                 935                 940                 


Ser Ser Gly Ala Pro Gly Val Arg Cys Arg His Leu Val Glu Glu Asp 
945                 950                 955                 960 


Phe His Asp Gly Leu Pro Gly Met His Leu Val Gly Glu Leu Asp Trp 
                965                 970                 975     


Leu Leu Pro Lys Asp Lys Asp Arg Thr Ala Asn Glu Ala Arg Arg Leu 
            980                 985                 990         


Leu Gly Gly Met Val Arg Pro Gly  Met Leu Val Pro Trp  Asp Gly Gly 
        995                 1000                 1005             


Glu Leu  Phe Ala Thr Leu Asn  Ala Ala Ser Gln Leu  His Val Ile 
    1010                 1015                 1020             


His Ala  Asp Ile Asn Ala Ala  Gln Asn Leu Gln Arg  Arg Phe Trp 
    1025                 1030                 1035             


Gly Arg  Cys Gly Glu Ala Ile  Arg Ile Val Cys Asn  Gln Leu Ser 
    1040                 1045                 1050             


Val Asp  Gly Ser Thr Arg Tyr  Glu Met Ala Lys Ala  Pro Lys Ala 
    1055                 1060                 1065             


Arg Leu  Leu Gly Ala Leu Gln  Gln Leu Lys Asn Gly  Asp Ala Pro 
    1070                 1075                 1080             


Phe His  Leu Thr Ser Ile Pro  Asn Ser Gln Lys Pro  Glu Asn Ser 
    1085                 1090                 1095             


Tyr Val  Met Thr Pro Thr Asn  Ala Gly Lys Lys Tyr  Arg Ala Gly 
    1100                 1105                 1110             


Pro Gly  Glu Lys Ser Ser Gly  Glu Glu Asp Glu Leu  Ala Leu Asp 
    1115                 1120                 1125             


Ile Val  Glu Gln Ala Glu Glu  Leu Ala Gln Gly Arg  Lys Thr Phe 
    1130                 1135                 1140             


Phe Arg  Asp Pro Ser Gly Val  Phe Phe Ala Pro Asp  Arg Trp Leu 
    1145                 1150                 1155             


Pro Ser  Glu Ile Tyr Trp Ser  Arg Ile Arg Arg Arg  Ile Trp Gln 
    1160                 1165                 1170             


Val Thr  Leu Glu Arg Asn Ser  Ser Gly Arg Gln Glu  Arg Ala Glu 
    1175                 1180                 1185             


Met Asp  Glu Met Pro Tyr 
    1190                 


<210>  130
<211>  370
<212>  PRT
<213>  Macaca mulatta

<400>  130

Met Val Glu Pro Met Asp Pro Arg Thr Phe Val Ser Asn Phe Asn Asn 
1               5                   10                  15      


Arg Pro Ile Leu Ser Gly Leu Asn Thr Val Trp Leu Cys Cys Glu Val 
            20                  25                  30          


Lys Thr Lys Asp Pro Ser Gly Pro Pro Leu Asp Ala Lys Ile Phe Gln 
        35                  40                  45              


Gly Lys Val Tyr Ser Lys Ala Lys Tyr His Pro Glu Met Arg Phe Leu 
    50                  55                  60                  


Arg Trp Phe His Lys Trp Arg Gln Leu His His Asp Gln Glu Tyr Lys 
65                  70                  75                  80  


Val Thr Trp Tyr Val Ser Trp Ser Pro Cys Thr Arg Cys Ala Asn Ser 
                85                  90                  95      


Val Ala Thr Phe Leu Ala Lys Asp Pro Lys Val Thr Leu Thr Ile Phe 
            100                 105                 110         


Val Ala Arg Leu Tyr Tyr Phe Trp Lys Pro Asp Tyr Gln Gln Ala Leu 
        115                 120                 125             


Arg Ile Leu Cys Gln Lys Arg Gly Gly Pro His Ala Thr Met Lys Ile 
    130                 135                 140                 


Met Asn Tyr Asn Glu Phe Gln Asp Cys Trp Asn Lys Phe Val Asp Gly 
145                 150                 155                 160 


Arg Gly Lys Pro Phe Lys Pro Arg Asn Asn Leu Pro Lys His Tyr Thr 
                165                 170                 175     


Leu Leu Gln Ala Thr Leu Gly Glu Leu Leu Arg His Leu Met Asp Pro 
            180                 185                 190         


Gly Thr Phe Thr Ser Asn Phe Asn Asn Lys Pro Trp Val Ser Gly Gln 
        195                 200                 205             


His Glu Thr Tyr Leu Cys Tyr Lys Val Glu Arg Leu His Asn Asp Thr 
    210                 215                 220                 


Trp Val Pro Leu Asn Gln His Arg Gly Phe Leu Arg Asn Gln Ala Pro 
225                 230                 235                 240 


Asn Ile His Gly Phe Pro Lys Gly Arg His Ala Glu Leu Cys Phe Leu 
                245                 250                 255     


Asp Leu Ile Pro Phe Trp Lys Leu Asp Gly Gln Gln Tyr Arg Val Thr 
            260                 265                 270         


Cys Phe Thr Ser Trp Ser Pro Cys Phe Ser Cys Ala Gln Glu Met Ala 
        275                 280                 285             


Lys Phe Ile Ser Asn Asn Glu His Val Ser Leu Cys Ile Phe Ala Ala 
    290                 295                 300                 


Arg Ile Tyr Asp Asp Gln Gly Arg Tyr Gln Glu Gly Leu Arg Ala Leu 
305                 310                 315                 320 


His Arg Asp Gly Ala Lys Ile Ala Met Met Asn Tyr Ser Glu Phe Glu 
                325                 330                 335     


Tyr Cys Trp Asp Thr Phe Val Asp Arg Gln Gly Arg Pro Phe Gln Pro 
            340                 345                 350         


Trp Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg 
        355                 360                 365             


Ala Ile 
    370 


<210>  131
<211>  384
<212>  PRT
<213>  Pan troglodytes

<400>  131

Met Lys Pro His Phe Arg Asn Pro Val Glu Arg Met Tyr Gln Asp Thr 
1               5                   10                  15      


Phe Ser Asp Asn Phe Tyr Asn Arg Pro Ile Leu Ser His Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Pro 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Lys Leu Lys Tyr 
    50                  55                  60                  


His Pro Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys Leu 
65                  70                  75                  80  


His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser Trp Ser Pro 
                85                  90                  95      


Cys Thr Lys Cys Thr Arg Asp Val Ala Thr Phe Leu Ala Glu Asp Pro 
            100                 105                 110         


Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Asp 
        115                 120                 125             


Pro Asp Tyr Gln Glu Ala Leu Arg Ser Leu Cys Gln Lys Arg Asp Gly 
    130                 135                 140                 


Pro Arg Ala Thr Met Lys Ile Met Asn Tyr Asp Glu Phe Gln His Cys 
145                 150                 155                 160 


Trp Ser Lys Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn 
                165                 170                 175     


Asn Leu Pro Lys Tyr Tyr Ile Leu Leu His Ile Met Leu Gly Glu Ile 
            180                 185                 190         


Leu Arg His Ser Met Asp Pro Pro Thr Phe Thr Ser Asn Phe Asn Asn 
        195                 200                 205             


Glu Leu Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val 
    210                 215                 220                 


Glu Arg Leu His Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly 
225                 230                 235                 240 


Phe Leu Cys Asn Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg 
                245                 250                 255     


His Ala Glu Leu Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp 
            260                 265                 270         


Leu His Gln Asp Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys 
        275                 280                 285             


Phe Ser Cys Ala Gln Glu Met Ala Lys Phe Ile Ser Asn Asn Lys His 
    290                 295                 300                 


Val Ser Leu Cys Ile Phe Ala Ala Arg Ile Tyr Asp Asp Gln Gly Arg 
305                 310                 315                 320 


Cys Gln Glu Gly Leu Arg Thr Leu Ala Lys Ala Gly Ala Lys Ile Ser 
                325                 330                 335     


Ile Met Thr Tyr Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp 
            340                 345                 350         


His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Glu Glu His Ser 
        355                 360                 365             


Gln Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn 
    370                 375                 380                 


<210>  132
<211>  377
<212>  PRT
<213>  Chlorocebus sabaeus

<400>  132

Met Asn Pro Gln Ile Arg Asn Met Val Glu Gln Met Glu Pro Asp Ile 
1               5                   10                  15      


Phe Val Tyr Tyr Phe Asn Asn Arg Pro Ile Leu Ser Gly Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Asp Pro Ser Gly Pro Pro 
        35                  40                  45              


Leu Asp Ala Asn Ile Phe Gln Gly Lys Leu Tyr Pro Glu Ala Lys Asp 
    50                  55                  60                  


His Pro Glu Met Lys Phe Leu His Trp Phe Arg Lys Trp Arg Gln Leu 
65                  70                  75                  80  


His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Val Ser Trp Ser Pro 
                85                  90                  95      


Cys Thr Arg Cys Ala Asn Ser Val Ala Thr Phe Leu Ala Glu Asp Pro 
            100                 105                 110         


Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Lys 
        115                 120                 125             


Pro Asp Tyr Gln Gln Ala Leu Arg Ile Leu Cys Gln Glu Arg Gly Gly 
    130                 135                 140                 


Pro His Ala Thr Met Lys Ile Met Asn Tyr Asn Glu Phe Gln His Cys 
145                 150                 155                 160 


Trp Asn Glu Phe Val Asp Gly Gln Gly Lys Pro Phe Lys Pro Arg Lys 
                165                 170                 175     


Asn Leu Pro Lys His Tyr Thr Leu Leu His Ala Thr Leu Gly Glu Leu 
            180                 185                 190         


Leu Arg His Val Met Asp Pro Gly Thr Phe Thr Ser Asn Phe Asn Asn 
        195                 200                 205             


Lys Pro Trp Val Ser Gly Gln Arg Glu Thr Tyr Leu Cys Tyr Lys Val 
    210                 215                 220                 


Glu Arg Ser His Asn Asp Thr Trp Val Leu Leu Asn Gln His Arg Gly 
225                 230                 235                 240 


Phe Leu Arg Asn Gln Ala Pro Asp Arg His Gly Phe Pro Lys Gly Arg 
                245                 250                 255     


His Ala Glu Leu Cys Phe Leu Asp Leu Ile Pro Phe Trp Lys Leu Asp 
            260                 265                 270         


Asp Gln Gln Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys Phe 
        275                 280                 285             


Ser Cys Ala Gln Lys Met Ala Lys Phe Ile Ser Asn Asn Lys His Val 
    290                 295                 300                 


Ser Leu Cys Ile Phe Ala Ala Arg Ile Tyr Asp Asp Gln Gly Arg Cys 
305                 310                 315                 320 


Gln Glu Gly Leu Arg Thr Leu His Arg Asp Gly Ala Lys Ile Ala Val 
                325                 330                 335     


Met Asn Tyr Ser Glu Phe Glu Tyr Cys Trp Asp Thr Phe Val Asp Arg 
            340                 345                 350         


Gln Gly Arg Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln 
        355                 360                 365             


Ala Leu Ser Gly Arg Leu Arg Ala Ile 
    370                 375         


<210>  133
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Lys Pro His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Pro 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Glu Leu Lys Tyr 
    50                  55                  60                  


His Pro Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys Leu 
65                  70                  75                  80  


His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser Trp Ser Pro 
                85                  90                  95      


Cys Thr Lys Cys Thr Arg Asp Met Ala Thr Phe Leu Ala Glu Asp Pro 
            100                 105                 110         


Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Asp 
        115                 120                 125             


Pro Asp Tyr Gln Glu Ala Leu Arg Ser Leu Cys Gln Lys Arg Asp Gly 
    130                 135                 140                 


Pro Arg Ala Thr Met Lys Ile Met Asn Tyr Asp Glu Phe Gln His Cys 
145                 150                 155                 160 


Trp Ser Lys Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn 
                165                 170                 175     


Asn Leu Pro Lys Tyr Tyr Ile Leu Leu His Ile Met Leu Gly Glu Ile 
            180                 185                 190         


Leu Arg His Ser Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn 
        195                 200                 205             


Glu Pro Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val 
    210                 215                 220                 


Glu Arg Met His Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly 
225                 230                 235                 240 


Phe Leu Cys Asn Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg 
                245                 250                 255     


His Ala Glu Leu Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp 
            260                 265                 270         


Leu Asp Gln Asp Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys 
        275                 280                 285             


Phe Ser Cys Ala Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His 
    290                 295                 300                 


Val Ser Leu Cys Ile Phe Thr Ala Arg Ile Tyr Asp Asp Gln Gly Arg 
305                 310                 315                 320 


Cys Gln Glu Gly Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser 
                325                 330                 335     


Ile Met Thr Tyr Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp 
            340                 345                 350         


His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser 
        355                 360                 365             


Gln Asp Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Glu Asn 
    370                 375                 380                 


<210>  134
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Lys Pro His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Arg 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Gln Pro Glu His 
    50                  55                  60                  


His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu Pro 
65                  70                  75                  80  


Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro Cys 
                85                  90                  95      


Pro Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ala Glu His Pro Asn 
            100                 105                 110         


Val Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu Arg 
        115                 120                 125             


Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg Val 
    130                 135                 140                 


Lys Ile Met Asp Asp Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe Val 
145                 150                 155                 160 


Tyr Ser Glu Gly Gln Pro Phe Met Pro Trp Tyr Lys Phe Asp Asp Asn 
                165                 170                 175     


Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Asn Pro Met 
            180                 185                 190         


Glu Ala Met Tyr Pro His Ile Phe Tyr Phe His Phe Lys Asn Leu Arg 
        195                 200                 205             


Lys Ala Tyr Gly Arg Asn Glu Ser Trp Leu Cys Phe Thr Met Glu Val 
    210                 215                 220                 


Val Lys His His Ser Pro Val Ser Trp Lys Arg Gly Val Phe Arg Asn 
225                 230                 235                 240 


Gln Val Asp Pro Glu Thr His Cys His Ala Glu Arg Cys Phe Leu Ser 
                245                 250                 255     


Trp Phe Cys Asp Asp Ile Leu Ser Pro Asn Thr Asn Tyr Glu Val Thr 
            260                 265                 270         


Trp Tyr Thr Ser Trp Ser Pro Cys Pro Glu Cys Ala Gly Glu Val Ala 
        275                 280                 285             


Glu Phe Leu Ala Arg His Ser Asn Val Asn Leu Thr Ile Phe Thr Ala 
    290                 295                 300                 


Arg Leu Tyr Tyr Phe Trp Asp Thr Asp Tyr Gln Glu Gly Leu Arg Ser 
305                 310                 315                 320 


Leu Ser Gln Glu Gly Ala Ser Val Glu Ile Met Gly Tyr Lys Asp Phe 
                325                 330                 335     


Lys Tyr Cys Trp Glu Asn Phe Val Tyr Asn Asp Asp Glu Pro Phe Lys 
            340                 345                 350         


Pro Trp Lys Gly Leu Lys Tyr Asn Phe Leu Phe Leu Asp Ser Lys Leu 
        355                 360                 365             


Gln Glu Ile Leu Glu 
    370             


<210>  135
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Asn Pro Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Tyr Asp Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr 
            20                  25                  30          


Thr Trp Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn Leu 
        35                  40                  45              


Leu Trp Asp Thr Gly Val Phe Arg Gly Gln Val Tyr Phe Lys Pro Gln 
    50                  55                  60                  


Tyr His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu 
65                  70                  75                  80  


Pro Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro 
                85                  90                  95      


Cys Pro Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ser Glu His Pro 
            100                 105                 110         


Asn Val Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu 
        115                 120                 125             


Arg Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg 
    130                 135                 140                 


Val Thr Ile Met Asp Tyr Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe 
145                 150                 155                 160 


Val Tyr Asn Glu Gly Gln Gln Phe Met Pro Trp Tyr Lys Phe Asp Glu 
                165                 170                 175     


Asn Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Tyr Leu 
            180                 185                 190         


Met Asp Pro Asp Thr Phe Thr Phe Asn Phe Asn Asn Asp Pro Leu Val 
        195                 200                 205             


Leu Arg Arg Arg Gln Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp 
    210                 215                 220                 


Asn Gly Thr Trp Val Leu Met Asp Gln His Met Gly Phe Leu Cys Asn 
225                 230                 235                 240 


Glu Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu 
                245                 250                 255     


Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile 
            260                 265                 270         


Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly 
        275                 280                 285             


Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg 
    290                 295                 300                 


Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys 
305                 310                 315                 320 


Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met 
                325                 330                 335     


Thr Tyr Asp Glu Phe Glu Tyr Cys Trp Asp Thr Phe Val Tyr Arg Gln 
            340                 345                 350         


Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Glu Glu His Ser Gln Ala 
        355                 360                 365             


Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn 
    370                 375                 380         


<210>  136
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  136

Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 
1               5                   10                  15      


Thr Pro Glu Ser Ser Gly Gly Ser 
            20                  


<210>  137
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Asn Pro Gln Ile Arg Asn Pro Met Lys Ala Met Tyr Pro Gly Thr 
1               5                   10                  15      


Phe Tyr Phe Gln Phe Lys Asn Leu Trp Glu Ala Asn Asp Arg Asn Glu 
            20                  25                  30          


Thr Trp Leu Cys Phe Thr Val Glu Gly Ile Lys Arg Arg Ser Val Val 
        35                  40                  45              


Ser Trp Lys Thr Gly Val Phe Arg Asn Gln Val Asp Ser Glu Thr His 
    50                  55                  60                  


Cys His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys Asp Asp Ile Leu 
65                  70                  75                  80  


Ser Pro Asn Thr Lys Tyr Gln Val Thr Trp Tyr Thr Ser Trp Ser Pro 
                85                  90                  95      


Cys Pro Asp Cys Ala Gly Glu Val Ala Glu Phe Leu Ala Arg His Ser 
            100                 105                 110         


Asn Val Asn Leu Thr Ile Phe Thr Ala Arg Leu Tyr Tyr Phe Gln Tyr 
        115                 120                 125             


Pro Cys Tyr Gln Glu Gly Leu Arg Ser Leu Ser Gln Glu Gly Val Ala 
    130                 135                 140                 


Val Glu Ile Met Asp Tyr Glu Asp Phe Lys Tyr Cys Trp Glu Asn Phe 
145                 150                 155                 160 


Val Tyr Asn Asp Asn Glu Pro Phe Lys Pro Trp Lys Gly Leu Lys Thr 
                165                 170                 175     


Asn Phe Arg Leu Leu Lys Arg Arg Leu Arg Glu Ser Leu Gln 
            180                 185                 190 


<210>  138
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  139
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Ala Leu Leu Thr Ala Glu Thr Phe Arg Leu Gln Phe Asn Asn Lys 
1               5                   10                  15      


Arg Arg Leu Arg Arg Pro Tyr Tyr Pro Arg Lys Ala Leu Leu Cys Tyr 
            20                  25                  30          


Gln Leu Thr Pro Gln Asn Gly Ser Thr Pro Thr Arg Gly Tyr Phe Glu 
        35                  40                  45              


Asn Lys Lys Lys Cys His Ala Glu Ile Cys Phe Ile Asn Glu Ile Lys 
    50                  55                  60                  


Ser Met Gly Leu Asp Glu Thr Gln Cys Tyr Gln Val Thr Cys Tyr Leu 
65                  70                  75                  80  


Thr Trp Ser Pro Cys Ser Ser Cys Ala Trp Glu Leu Val Asp Phe Ile 
                85                  90                  95      


Lys Ala His Asp His Leu Asn Leu Gly Ile Phe Ala Ser Arg Leu Tyr 
            100                 105                 110         


Tyr His Trp Cys Lys Pro Gln Gln Lys Gly Leu Arg Leu Leu Cys Gly 
        115                 120                 125             


Ser Gln Val Pro Val Glu Val Met Gly Phe Pro Lys Phe Ala Asp Cys 
    130                 135                 140                 


Trp Glu Asn Phe Val Asp His Glu Lys Pro Leu Ser Phe Asn Pro Tyr 
145                 150                 155                 160 


Lys Met Leu Glu Glu Leu Asp Lys Asn Ser Arg Ala Ile Lys Arg Arg 
                165                 170                 175     


Leu Glu Arg Ile Lys Ile Pro Gly Val Arg Ala Gln Gly Arg Tyr Met 
            180                 185                 190         


Asp Ile Leu Cys Asp Ala Glu Val 
        195                 200 


<210>  140
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Asn Pro Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Tyr Asp Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr 
            20                  25                  30          


Thr Trp Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn Leu 
        35                  40                  45              


Leu Trp Asp Thr Gly Val Phe Arg Gly Pro Val Leu Pro Lys Arg Gln 
    50                  55                  60                  


Ser Asn His Arg Gln Glu Val Tyr Phe Arg Phe Glu Asn His Ala Glu 
65                  70                  75                  80  


Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Arg Leu Pro Ala Asn Arg 
                85                  90                  95      


Arg Phe Gln Ile Thr Trp Phe Val Ser Trp Asn Pro Cys Leu Pro Cys 
            100                 105                 110         


Val Val Lys Val Thr Lys Phe Leu Ala Glu His Pro Asn Val Thr Leu 
        115                 120                 125             


Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Arg Asp Arg Asp Trp Arg 
    130                 135                 140                 


Trp Val Leu Leu Arg Leu His Lys Ala Gly Ala Arg Val Lys Ile Met 
145                 150                 155                 160 


Asp Tyr Glu Asp Phe Ala Tyr Cys Trp Glu Asn Phe Val Cys Asn Glu 
                165                 170                 175     


Gly Gln Pro Phe Met Pro Trp Tyr Lys Phe Asp Asp Asn Tyr Ala Ser 
            180                 185                 190         


Leu His Arg Thr Leu Lys Glu Ile Leu Arg Asn Pro Met Glu Ala Met 
        195                 200                 205             


Tyr Pro His Ile Phe Tyr Phe His Phe Lys Asn Leu Leu Lys Ala Cys 
    210                 215                 220                 


Gly Arg Asn Glu Ser Trp Leu Cys Phe Thr Met Glu Val Thr Lys His 
225                 230                 235                 240 


His Ser Ala Val Phe Arg Lys Arg Gly Val Phe Arg Asn Gln Val Asp 
                245                 250                 255     


Pro Glu Thr His Cys His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys 
            260                 265                 270         


Asp Asp Ile Leu Ser Pro Asn Thr Asn Tyr Glu Val Thr Trp Tyr Thr 
        275                 280                 285             


Ser Trp Ser Pro Cys Pro Glu Cys Ala Gly Glu Val Ala Glu Phe Leu 
    290                 295                 300                 


Ala Arg His Ser Asn Val Asn Leu Thr Ile Phe Thr Ala Arg Leu Cys 
305                 310                 315                 320 


Tyr Phe Trp Asp Thr Asp Tyr Gln Glu Gly Leu Cys Ser Leu Ser Gln 
                325                 330                 335     


Glu Gly Ala Ser Val Lys Ile Met Gly Tyr Lys Asp Phe Val Ser Cys 
            340                 345                 350         


Trp Lys Asn Phe Val Tyr Ser Asp Asp Glu Pro Phe Lys Pro Trp Lys 
        355                 360                 365             


Gly Leu Gln Thr Asn Phe Arg Leu Leu Lys Arg Arg Leu Arg Glu Ile 
    370                 375                 380                 


Leu Gln 
385     


<210>  141
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  141

Gly Ser His Met Thr Asn Asp Ile Tyr Phe Met Thr Leu Ala Ile Glu 
1               5                   10                  15      


Glu Ala Lys Lys Ala Ala Gln Leu Pro Glu Val Pro Ile Gly Ala Ile 
            20                  25                  30          


Ile Thr Lys Asp Asp Glu Val Ile Ala Arg Ala His Asn Leu Arg Glu 
        35                  40                  45              


Thr Leu Gln Gln Pro Thr Ala His Ala Glu His Ile Ala Ile Glu Arg 
    50                  55                  60                  


Ala Ala Lys Val Leu Gly Ser Trp Arg Leu Glu Gly Cys Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Thr Ile Val Met Ser 
                85                  90                  95      


Arg Ile Pro Arg Val Val Tyr Gly Ala Ala Asn Pro Lys Gly Gly Cys 
            100                 105                 110         


Ser Gly Ser Leu Met Asn Leu Leu Gln Gln Ser Asn Phe Asn His Arg 
        115                 120                 125             


Ala Ile Val Asp Lys Gly Val Leu Lys Glu Ala Cys Ser Thr Leu Leu 
    130                 135                 140                 


Thr Thr Phe Phe Lys Asn Leu Arg Ala Asn Lys Lys Ser Thr Asn 
145                 150                 155                 


<210>  142
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  142

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
1               5                   10                  15      


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
        35                  40                  45              


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
    50                  55                  60                  


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
65                  70                  75                  80  


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
                85                  90                  95      


<210>  143
<211>  1371
<212>  PRT
<213>  Streptococcus dysgalactiae

<400>  143

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Met Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gln 
    530                 535                 540                 


Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Ile Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Cys Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Ile Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Gly  Asp 
    1370     


<210>  144
<211>  1371
<212>  PRT
<213>  Streptococcus dysgalactiae

<400>  144

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Ile Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Ile Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Gly  Asp 
    1370     


<210>  145
<211>  1348
<212>  PRT
<213>  Streptococcus equi

<400>  145

Met Lys Lys Pro Tyr Thr Ile Ala Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Val Val Val Thr Asp Asp Tyr Arg Val Pro Thr Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Glu Arg Lys Thr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asp Thr Ala Glu Gly Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Lys Glu Ile Phe Thr Glu Glu Met Ala Lys Val Asp Asp Gly 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Asp Ser Phe Tyr Val Leu Glu Asp Lys Glu 
            100                 105                 110         


Gly Asn Lys His Pro Ile Phe Ala Asn Leu Ala Asp Glu Val Ala Tyr 
        115                 120                 125             


His Lys Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Val Asp 
    130                 135                 140                 


Asn Pro Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Val Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Thr Leu Ser Ser 
                165                 170                 175     


Lys Asn Asn Asn Leu Gln Lys Ser Phe Asp His Leu Val Asp Thr Tyr 
            180                 185                 190         


Asn Leu Leu Phe Glu Glu Gln Arg Leu Leu Thr Glu Gly Ile Asn Ala 
        195                 200                 205             


Lys Glu Leu Leu Ser Ala Ala Leu Ser Lys Ser Lys Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ser Leu Ile Pro Gly Gln Lys Lys Thr Gly Ile Phe Gly Asn 
225                 230                 235                 240 


Ile Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ala Asn Phe 
                245                 250                 255     


Gly Leu Ser Lys Asp Val Lys Leu Gln Leu Ala Lys Asp Thr Tyr Ala 
            260                 265                 270         


Asp Asp Leu Asp Ser Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Thr Glu Ser Asp Glu Ile Thr Arg Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Arg Glu His His Lys Asp Leu Val Thr Leu Lys 
                325                 330                 335     


Thr Leu Ile Lys Asp Gln Leu Pro Glu Lys Tyr Gln Glu Ile Phe Leu 
            340                 345                 350         


Asp Lys Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Gly Gln Val Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Tyr Leu Lys Pro Ile Leu Ala Arg Leu Asp 
    370                 375                 380                 


Gly Ser Glu Pro Leu Leu Leu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Glu Glu Leu His Ala Ile Leu Arg Arg Gln Glu Val Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Lys Lys Ile Glu Ser Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly His Ser Arg Phe Ala Trp 
    450                 455                 460                 


Val Lys Arg Lys Phe Asp Gly Ala Ile Arg Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Ile Val Asp Glu Glu Ala Ser Ala Gln Ile Phe Ile Glu Lys Met Thr 
                485                 490                 495     


Lys Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Ala Thr Glu Gly Met Thr Arg Pro Gln Phe Leu Ser Ala Asp Gln 
    530                 535                 540                 


Lys Gln Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asn Tyr Phe Lys Lys Ile Glu Cys Trp Asp 
                565                 570                 575     


Ser Val Glu Ile Thr Gly Val Glu Asp Ser Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Gln Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Pro Asp Asn Gln Lys Ile Ile Glu Asp Ile Ile Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Lys Met Ile Ser Lys Arg Leu Asp Gln Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Lys Val Val Leu Asn Lys Leu Glu Arg His His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Gly Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ala Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Ser Glu Leu Ser Phe 
    690                 695                 700                 


Ile Asp Glu Ile Ala Lys Ala Gln Val Ile Gly Lys Thr Glu Tyr Ser 
705                 710                 715                 720 


Lys Asp Leu Val Gly Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Ser Gln Thr Ile Lys Ile Val Asp Glu Leu Val Lys Ile Met Gly 
            740                 745                 750         


Tyr Leu Pro Gln Gln Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Gln Gly Ile Lys Asn Ala Arg Gln Arg Met Arg Lys Leu Glu 
    770                 775                 780                 


Glu Thr Ala Lys Lys Leu Gly Ser Asn Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Asp Asn Ser Gln Leu Gln Asn Asp Lys Arg Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Asp Asp Leu Asp Ile Asp Tyr Leu 
            820                 825                 830         


Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe Ile Lys Asn 
        835                 840                 845             


Asn Ser Ile Asp Asn Lys Val Leu Thr Ser Gln Gly Ala Asn Arg Gly 
    850                 855                 860                 


Lys Leu Asp Asn Val Pro Ser Glu Ala Ile Val Arg Lys Met Lys Gly 
865                 870                 875                 880 


Tyr Trp Gln Ser Leu Leu Arg Ala Gly Ala Ile Ser Lys Gln Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Gln Val Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Phe Asn Thr Glu Phe Asp Asp 
    930                 935                 940                 


His Asn Lys Arg Ile Arg Lys Val His Ile Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Glu Phe Gly Leu Tyr Lys Ile Arg Asp 
                965                 970                 975     


Ile Asn His Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Ala Lys Ala Ile Leu Gly Lys Tyr  Pro Gln Leu Ala Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Pro Lys Tyr  Asn Ser Phe Lys Glu  Arg Gln Lys 
    1010                 1015                 1020             


Ala Thr  Gln Lys Met Leu Phe  Tyr Ser Asn Ile Leu  Lys Phe Phe 
    1025                 1030                 1035             


Lys Asp  Gln Glu Ser Leu His  Val Asn Ser Asp Gly  Glu Glu Ile 
    1040                 1045                 1050             


Trp Asn  Ala Asn Lys His Leu  Pro Ile Ile Lys Asn  Val Leu Ser 
    1055                 1060                 1065             


Ile Pro  Gln Val Asn Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly 
    1070                 1075                 1080             


Gly Phe  Tyr Lys Glu Ser Ile  Leu Ser Lys Gly Asn  Ser Asp Lys 
    1085                 1090                 1095             


Leu Ile  Pro Arg Lys Asn Asn  Trp Asp Thr Arg Lys  Tyr Gly Gly 
    1100                 1105                 1110             


Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val Leu Val  Ile Ala Lys 
    1115                 1120                 1125             


Met Glu  Lys Gly Lys Ala Lys  Val Leu Lys Pro Val  Lys Glu Met 
    1130                 1135                 1140             


Val Gly  Ile Thr Ile Met Glu  Arg Thr Ala Phe Glu  Glu Asn Pro 
    1145                 1150                 1155             


Val Val  Phe Leu Glu Ala Arg  Gly Tyr Arg Glu Ile  Gln Glu His 
    1160                 1165                 1170             


Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn 
    1175                 1180                 1185             


Gly Arg  Arg Arg Leu Leu Ala  Ser Ala Ser Glu Leu  Gln Lys Gly 
    1190                 1195                 1200             


Asn Glu  Leu Phe Leu Pro Val  Asp Tyr Met Thr Phe  Leu Tyr Leu 
    1205                 1210                 1215             


Ala Ala  His Tyr His Glu Leu  Thr Gly Ser Ser Glu  Asp Val Leu 
    1220                 1225                 1230             


Arg Lys  Lys Tyr Phe Val Asp  Arg His Leu His Tyr  Phe Asp Asp 
    1235                 1240                 1245             


Ile Ile  Gln Met Ile Asn Asp  Phe Ala Glu Arg His  Ile Leu Ala 
    1250                 1255                 1260             


Ser Ser  Asn Leu Glu Lys Ile  Asn His Thr Tyr His  Asn Asn Ser 
    1265                 1270                 1275             


Asp Leu  Pro Val Asn Glu Arg  Ala Glu Asn Ile Ile  Asn Val Phe 
    1280                 1285                 1290             


Thr Phe  Val Ala Leu Gly Ala  Pro Ala Ala Phe Lys  Phe Phe Asp 
    1295                 1300                 1305             


Ala Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu 
    1310                 1315                 1320             


Asn Ala  Thr Leu Ile His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr 
    1325                 1330                 1335             


Arg Ile  Asp Leu Ser Gln Leu  Gly Glu Asn 
    1340                 1345             


<210>  146
<211>  1348
<212>  PRT
<213>  Streptococcus equi

<400>  146

Met Lys Lys Pro Tyr Thr Ile Ala Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Val Val Val Thr Asp Asp Tyr Arg Val Pro Thr Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Glu Arg Lys Thr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asp Thr Ala Glu Gly Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Lys Glu Ile Phe Thr Glu Glu Met Ala Lys Val Asp Asp Gly 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Asp Ser Phe Tyr Val Leu Glu Asp Lys Glu 
            100                 105                 110         


Gly Asn Lys His Pro Ile Phe Ala Asn Leu Ala Asp Glu Val Ala Tyr 
        115                 120                 125             


His Lys Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Val Asp 
    130                 135                 140                 


Asn Pro Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Val Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Thr Leu Ser Ser 
                165                 170                 175     


Lys Asn Asn Asn Leu Gln Lys Ser Phe Asp His Leu Val Asp Thr Tyr 
            180                 185                 190         


Asn Leu Leu Phe Glu Glu Gln Arg Leu Leu Thr Glu Gly Ile Asn Ala 
        195                 200                 205             


Lys Glu Leu Leu Ser Ala Ala Leu Ser Lys Ser Lys Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ser Leu Ile Pro Gly Gln Lys Lys Thr Gly Ile Phe Gly Asn 
225                 230                 235                 240 


Ile Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ala Asn Phe 
                245                 250                 255     


Gly Leu Ser Lys Asp Val Lys Leu Gln Leu Ala Lys Asp Thr Tyr Ala 
            260                 265                 270         


Asp Asp Leu Asp Ser Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Thr Glu Ser Asp Glu Ile Thr Arg Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Arg Glu His His Lys Asp Leu Val Thr Leu Lys 
                325                 330                 335     


Thr Leu Ile Lys Asp Gln Leu Pro Glu Lys Tyr Gln Glu Ile Phe Leu 
            340                 345                 350         


Asp Lys Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Gly Gln Val Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Tyr Leu Lys Pro Ile Leu Ala Arg Leu Asp 
    370                 375                 380                 


Gly Ser Glu Pro Leu Leu Leu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Glu Glu Leu His Ala Ile Leu Arg Arg Gln Glu Val Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Lys Lys Ile Glu Ser Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly His Ser Arg Phe Ala Trp 
    450                 455                 460                 


Val Lys Arg Lys Phe Asp Gly Ala Ile Arg Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Ile Val Asp Glu Glu Ala Ser Ala Gln Ile Phe Ile Glu Lys Met Thr 
                485                 490                 495     


Lys Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Ala Thr Glu Gly Met Thr Arg Pro Gln Phe Leu Ser Ala Asp Gln 
    530                 535                 540                 


Lys Gln Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asn Tyr Phe Lys Lys Ile Glu Cys Trp Asp 
                565                 570                 575     


Ser Val Glu Ile Thr Gly Val Glu Asp Ser Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Gln Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Pro Asp Asn Gln Lys Ile Ile Glu Asp Ile Ile Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Lys Met Ile Ser Lys Arg Leu Asp Gln Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Lys Val Val Leu Asn Lys Leu Glu Arg His His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Gly Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ala Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Ser Glu Leu Ser Phe 
    690                 695                 700                 


Ile Asp Glu Ile Ala Lys Ala Gln Val Ile Gly Lys Thr Glu Tyr Ser 
705                 710                 715                 720 


Lys Asp Leu Val Gly Asn Leu Ala Ser Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Ser Gln Thr Ile Lys Ile Val Asp Glu Leu Val Lys Ile Met Gly 
            740                 745                 750         


Tyr Leu Pro Gln Gln Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Gln Gly Ile Lys Asn Ala Arg Gln Arg Met Arg Lys Leu Glu 
    770                 775                 780                 


Glu Thr Ala Lys Lys Leu Gly Ser Asn Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Asp Asn Ser Gln Leu Gln Asn Asp Lys Arg Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Asp Asp Leu Asp Ile Asp Tyr Leu 
            820                 825                 830         


Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe Ile Lys Asn 
        835                 840                 845             


Asn Ser Ile Asp Asn Lys Val Leu Thr Ser Gln Gly Ala Asn Arg Gly 
    850                 855                 860                 


Lys Leu Asp Asn Val Pro Ser Glu Ala Ile Val Arg Lys Met Lys Gly 
865                 870                 875                 880 


Tyr Trp Gln Ser Leu Leu Arg Ala Gly Ala Ile Ser Lys Gln Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Gln Val Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Phe Asn Thr Glu Phe Asp Asp 
    930                 935                 940                 


His Asn Lys Arg Ile Arg Lys Val His Ile Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Glu Phe Gly Leu Tyr Lys Ile Arg Asp 
                965                 970                 975     


Ile Asn His Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Ala Lys Ala Ile Leu Gly Lys Tyr  Pro Gln Leu Ala Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Pro Lys Tyr  Asn Ser Phe Lys Glu  Arg Gln Lys 
    1010                 1015                 1020             


Ala Thr  Gln Lys Thr Leu Phe  Tyr Ser Asn Ile Leu  Lys Phe Phe 
    1025                 1030                 1035             


Lys Asp  Gln Glu Ser Leu His  Val Asn Ser Asp Gly  Glu Glu Ile 
    1040                 1045                 1050             


Trp Asn  Ala Asn Lys His Leu  Pro Ile Ile Lys Asn  Val Leu Ser 
    1055                 1060                 1065             


Ile Pro  Gln Val Asn Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly 
    1070                 1075                 1080             


Gly Phe  Tyr Lys Glu Ser Ile  Leu Ser Lys Gly Asn  Ser Asp Lys 
    1085                 1090                 1095             


Leu Ile  Pro Arg Lys Asn Asn  Trp Asp Thr Arg Lys  Tyr Gly Gly 
    1100                 1105                 1110             


Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val Leu Val  Ile Ala Lys 
    1115                 1120                 1125             


Met Glu  Lys Gly Lys Ala Lys  Val Leu Lys Pro Val  Lys Glu Met 
    1130                 1135                 1140             


Val Gly  Ile Thr Ile Met Glu  Arg Ile Ala Phe Glu  Glu Asn Pro 
    1145                 1150                 1155             


Val Val  Phe Leu Glu Ala Lys  Gly Tyr Arg Glu Ile  Gln Glu His 
    1160                 1165                 1170             


Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn 
    1175                 1180                 1185             


Gly Arg  Arg Arg Leu Leu Ala  Ser Ala Ser Glu Leu  Gln Lys Gly 
    1190                 1195                 1200             


Asn Glu  Leu Phe Leu Pro Val  Asp Tyr Met Thr Phe  Leu Tyr Leu 
    1205                 1210                 1215             


Ala Ala  His Tyr His Glu Leu  Thr Gly Ser Ser Glu  Asp Val Leu 
    1220                 1225                 1230             


Arg Lys  Lys Tyr Phe Val Glu  Arg His Leu His Tyr  Phe Asp Asp 
    1235                 1240                 1245             


Ile Ile  Gln Met Ile Asn Asp  Phe Ala Glu Arg His  Ile Leu Ala 
    1250                 1255                 1260             


Ser Ser  Asn Leu Glu Lys Ile  Asn His Thr Tyr His  Asn Asn Ser 
    1265                 1270                 1275             


Asp Leu  Pro Ile Asn Glu Arg  Ala Glu Asn Ile Ile  Asn Val Phe 
    1280                 1285                 1290             


Thr Phe  Val Ala Leu Gly Ala  Pro Ala Ala Phe Lys  Phe Phe Asp 
    1295                 1300                 1305             


Ala Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu 
    1310                 1315                 1320             


Asn Ala  Thr Leu Ile His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr 
    1325                 1330                 1335             


Arg Ile  Asp Leu Ser Gln Leu  Gly Glu Asn 
    1340                 1345             


<210>  147
<211>  1348
<212>  PRT
<213>  Streptococcus equi

<400>  147

Met Lys Lys Pro Tyr Thr Ile Ala Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Val Val Val Thr Asp Asp Tyr Arg Val Pro Thr Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Glu Arg Lys Thr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asp Thr Ala Glu Gly Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Pro Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Phe Leu Lys Glu Ile Phe Thr Glu Glu Met Ala Lys Val Asp Asp Gly 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Asp Ser Phe Tyr Val Leu Glu Asp Lys Glu 
            100                 105                 110         


Gly Asn Lys His Pro Ile Phe Ala Asn Leu Ala Asp Glu Val Ala Tyr 
        115                 120                 125             


His Lys Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Val Asp 
    130                 135                 140                 


Asn Pro Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Val Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Thr Leu Ser Ser 
                165                 170                 175     


Lys Asn Asn Asn Leu Gln Lys Ser Phe Asp His Leu Val Asp Thr Tyr 
            180                 185                 190         


Asn Leu Leu Phe Glu Glu Gln Arg Leu Leu Thr Glu Gly Ile Asn Ala 
        195                 200                 205             


Lys Glu Leu Leu Ser Ala Ala Leu Ser Lys Ser Lys Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ser Leu Ile Pro Gly Gln Lys Lys Thr Gly Ile Phe Gly Asn 
225                 230                 235                 240 


Ile Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ala Asn Phe 
                245                 250                 255     


Gly Leu Ser Lys Asp Val Lys Leu Gln Leu Ala Lys Asp Thr Tyr Ala 
            260                 265                 270         


Asp Asp Leu Asp Ser Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Thr Glu Ser Asp Glu Ile Thr Arg Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Arg Glu His His Lys Asp Leu Val Thr Leu Lys 
                325                 330                 335     


Thr Leu Ile Lys Asp Gln Leu Pro Glu Lys Tyr Gln Glu Ile Phe Leu 
            340                 345                 350         


Asp Lys Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Gly Gln Val Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Tyr Leu Lys Pro Ile Leu Ala Arg Leu Asp 
    370                 375                 380                 


Gly Ser Glu Pro Leu Leu Leu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Glu Glu Leu His Ala Ile Leu Arg Arg Gln Glu Val Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Lys Lys Ile Glu Ser Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly His Ser Arg Phe Ala Trp 
    450                 455                 460                 


Val Lys Arg Lys Phe Asp Gly Ala Ile Arg Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Ile Val Asp Glu Glu Ala Ser Ala Gln Ile Phe Ile Glu Lys Met Thr 
                485                 490                 495     


Lys Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Ala Thr Glu Gly Met Thr Arg Pro Gln Phe Leu Ser Ala Asp Gln 
    530                 535                 540                 


Lys Gln Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asn Tyr Phe Lys Lys Ile Glu Cys Trp Asp 
                565                 570                 575     


Ser Val Glu Ile Thr Gly Val Glu Asp Ser Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Gln Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Pro Asp Asn Gln Lys Ile Ile Glu Asp Ile Ile Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Lys Met Ile Ser Lys Arg Leu Asp Gln Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Lys Val Val Leu Asn Lys Leu Glu Arg His His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Gly Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ala Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Ser Glu Leu Ser Phe 
    690                 695                 700                 


Ile Asp Glu Ile Ala Lys Ala Gln Val Ile Gly Lys Thr Glu Tyr Ser 
705                 710                 715                 720 


Lys Asp Leu Val Gly Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Ser Gln Thr Ile Lys Ile Val Asp Glu Leu Val Lys Ile Met Gly 
            740                 745                 750         


Tyr Leu Pro Gln Gln Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Gln Gly Ile Lys Asn Ala Arg Gln Arg Met Arg Lys Leu Glu 
    770                 775                 780                 


Glu Thr Ala Lys Lys Leu Gly Ser Asn Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Asp Asn Ser Gln Leu Gln Asn Asp Lys Arg Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Asp Asp Leu Asp Ile Asp Tyr Leu 
            820                 825                 830         


Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe Ile Lys Asn 
        835                 840                 845             


Asn Ser Ile Asp Asn Lys Val Leu Thr Ser Gln Gly Ala Asn Arg Gly 
    850                 855                 860                 


Lys Leu Asp Asn Val Pro Ser Glu Ala Ile Val Arg Lys Met Lys Gly 
865                 870                 875                 880 


Tyr Trp Gln Ser Leu Leu Arg Ala Gly Ala Ile Ser Lys Gln Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Gln Val Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Gln Leu Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Phe Asn Thr Glu Phe Asp Asp 
    930                 935                 940                 


His Asn Lys Arg Ile Arg Lys Val His Ile Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Glu Phe Gly Leu Tyr Lys Ile Arg Asp 
                965                 970                 975     


Ile Asn His Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Ala Lys Ala Ile Leu Gly Lys Tyr  Pro Gln Leu Ala Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Pro Lys Tyr  Asn Ser Phe Lys Glu  Arg Gln Lys 
    1010                 1015                 1020             


Ala Thr  Gln Lys Thr Leu Phe  Tyr Ser Asn Ile Leu  Lys Phe Phe 
    1025                 1030                 1035             


Lys Asp  Gln Glu Ser Leu His  Val Asn Ser Asp Gly  Glu Glu Ile 
    1040                 1045                 1050             


Trp Asn  Ala Asn Lys His Leu  Pro Ile Ile Lys Asn  Val Leu Ser 
    1055                 1060                 1065             


Ile Pro  Gln Val Asn Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly 
    1070                 1075                 1080             


Gly Phe  Tyr Lys Glu Ser Ile  Leu Ser Lys Gly Asn  Ser Asp Lys 
    1085                 1090                 1095             


Leu Ile  Pro Arg Lys Asn Asn  Trp Asp Thr Arg Lys  Tyr Gly Gly 
    1100                 1105                 1110             


Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val Leu Val  Ile Ala Lys 
    1115                 1120                 1125             


Met Glu  Lys Gly Lys Ala Lys  Val Leu Lys Pro Val  Lys Glu Met 
    1130                 1135                 1140             


Val Gly  Ile Thr Ile Met Glu  Arg Ile Ala Phe Glu  Glu Asn Pro 
    1145                 1150                 1155             


Val Val  Phe Leu Glu Ala Lys  Gly Tyr Arg Glu Ile  Gln Glu His 
    1160                 1165                 1170             


Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn 
    1175                 1180                 1185             


Gly Arg  Arg Arg Leu Leu Ala  Ser Ala Ser Glu Leu  Gln Lys Gly 
    1190                 1195                 1200             


Asn Glu  Leu Phe Leu Pro Val  Asp Tyr Met Thr Phe  Leu Tyr Leu 
    1205                 1210                 1215             


Ala Ala  His Tyr His Glu Leu  Thr Gly Ser Ser Glu  Asp Val Leu 
    1220                 1225                 1230             


Arg Lys  Lys Tyr Phe Val Glu  Arg His Leu His Tyr  Phe Asp Asp 
    1235                 1240                 1245             


Ile Ile  Gln Met Ile Asn Asp  Phe Ala Glu Arg His  Ile Leu Ala 
    1250                 1255                 1260             


Ser Ser  Asn Leu Glu Lys Ile  Asn His Thr Tyr His  Asn Asn Ser 
    1265                 1270                 1275             


Asp Leu  Pro Val Asn Glu Arg  Ala Glu Asn Ile Ile  Asn Val Phe 
    1280                 1285                 1290             


Thr Phe  Val Ala Leu Gly Ala  Pro Ala Ala Phe Lys  Phe Phe Asp 
    1295                 1300                 1305             


Ala Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu 
    1310                 1315                 1320             


Asn Ala  Thr Leu Ile His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr 
    1325                 1330                 1335             


Arg Ile  Asp Leu Ser Gln Leu  Gly Glu Asn 
    1340                 1345             


<210>  148
<211>  1377
<212>  PRT
<213>  Streptococcus equinus

<400>  148

Met Glu Lys Thr Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Ala Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Lys Glu Met Ala Lys Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Glu Ser Phe Leu Thr Asp Asp Asp Lys Thr 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Thr Tyr 
        115                 120                 125             


His Gln Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Ile Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ala Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Lys Gln Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Val Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Ala Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Glu Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Thr Phe Ile Lys Val Asn Asn Phe Asp Lys Tyr His Glu Ile Phe Lys 
            340                 345                 350         


Asp Lys Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Ile Phe Tyr Lys His Leu Lys Ser Ile Ile Ser Glu Lys Asn 
    370                 375                 380                 


Gly Gly Gln Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Thr Ile Leu Arg Arg Gln Gly Glu Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Ala Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Lys Tyr His Ser Asp Glu Pro Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Val Val Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Tyr Val Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Lys Ser Phe Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Ala Lys Leu Leu Ser Tyr Leu Asn Asn Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Asn Asp Leu Ile Gly Leu Asp Lys Asp Ser Lys Ser Phe Asn Ala Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asp Lys Thr Asn Glu Gln Ile Ile Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Asp Met Ile His Glu Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Ser Gln Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Phe Leu Ile Asp Asp Gly 
        675                 680                 685             


Asp Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser 
    690                 695                 700                 


Phe Lys Thr Thr Ile Gln Glu Ala Gln Val Val Gly Asp Val Asp Asp 
705                 710                 715                 720 


Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly His Asn Pro Gln Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Ile Thr Gly Tyr Gly Arg Asn Arg Ser Asn Gln Arg Leu Lys Arg Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Glu Phe Gly Ser Asp Ile Leu Ser Lys Lys Lys 
785                 790                 795                 800 


Pro Ser Tyr Val Asp Ser Lys Val Glu Asn Ser His Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Glu Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu 
    850                 855                 860                 


Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile 
865                 870                 875                 880 


Glu Ile Val Arg Asn Arg Lys Ser Tyr Trp Tyr Lys Leu Tyr Lys Ser 
                885                 890                 895     


Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Thr Glu Thr Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala 
    930                 935                 940                 


Arg Phe Asn Thr Lys Cys Asp Glu Asn Asp Lys Val Ile Arg Asp Val 
945                 950                 955                 960 


Lys Val Ile Thr Leu Lys Ser Ser Leu Val Ser Gln Phe Arg Lys Glu 
                965                 970                 975     


Phe Lys Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Gly Thr Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Ala Pro Glu Phe  Val Tyr Gly Glu Tyr  Lys Lys Tyr 
    1010                 1015                 1020             


Asp Val  Arg Lys Leu Val Ala  Lys Ser Ser Asp Asn  His Ser Glu 
    1025                 1030                 1035             


Leu Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met 
    1040                 1045                 1050             


Asn Phe  Phe Lys Thr Glu Val  Lys Tyr Ala Asp Gly  Arg Val Phe 
    1055                 1060                 1065             


Glu Arg  Pro Asp Ile Glu Thr  Asn Ala Asp Gly Glu  Val Val Trp 
    1070                 1075                 1080             


Asn Lys  Gln Arg Asp Phe Asn  Ile Val Arg Lys Val  Leu Ser Tyr 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Val Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Thr Lys Lys  Leu Gln Trp Glu Thr  Gln Lys Tyr 
    1130                 1135                 1140             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1145                 1150                 1155             


Ala Asp  Val Glu Lys Gly Lys  Thr Arg Lys Leu Lys  Thr Val Lys 
    1160                 1165                 1170             


Glu Leu  Val Gly Ile Ser Ile  Met Glu Arg Ser Ser  Phe Glu Glu 
    1175                 1180                 1185             


Asn Pro  Val Ser Phe Leu Glu  Lys Lys Gly Tyr His  Asn Val Gln 
    1190                 1195                 1200             


Glu Asp  Lys Leu Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Phe 
    1205                 1210                 1215             


Glu Gly  Gly Arg Arg Arg Leu  Leu Ala Ser Ala Thr  Glu Leu Gln 
    1220                 1225                 1230             


Lys Gly  Asn Glu Val Val Leu  Pro Gln Tyr Met Val  Asn Leu Leu 
    1235                 1240                 1245             


Tyr His  Ser Gln His Val Asn  Asn Ser His Lys Pro  Glu His Leu 
    1250                 1255                 1260             


Asn Tyr  Val Lys Gln His Lys  Asp Glu Phe Lys Asp  Ile Phe Asn 
    1265                 1270                 1275             


Leu Ile  Ile Ser Ile Ala Arg  Ile Asn Ile Leu Lys  Pro Lys Val 
    1280                 1285                 1290             


Val Asp  Asn Leu Ile Asn Glu  Phe Thr Glu Tyr Gly  Gln Glu Asp 
    1295                 1300                 1305             


Ile Ser  Ser Leu Ser Glu Ser  Phe Ile Asn Leu Leu  Lys Phe Ile 
    1310                 1315                 1320             


Ser Phe  Gly Ala Pro Gly Ala  Phe Lys Phe Leu Lys  Leu Asp Val 
    1325                 1330                 1335             


Lys Gln  Ser Asn Leu Arg Tyr  Lys Ser Thr Thr Glu  Ala Leu Ser 
    1340                 1345                 1350             


Ala Thr  Leu Ile His Gln Ser  Val Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Ser Lys Leu Gly  Glu Glu 
    1370                 1375         


<210>  149
<211>  1370
<212>  PRT
<213>  Streptococcus gallolyticus

<400>  149

Met Thr Lys Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Thr Lys Val Asp Glu 
                85                  90                  95      


Ser Phe Phe Tyr Arg Leu Asp Glu Ser Phe Leu Thr Thr Asp Glu Lys 
            100                 105                 110         


Asp Phe Glu Arg His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala 
        115                 120                 125             


Tyr His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Asn Tyr Leu Ala 
    130                 135                 140                 


Asp Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asn 
                165                 170                 175     


Ala Glu Asn Thr Asp Val Gln Lys Leu Phe Thr Asp Phe Val Gly Val 
            180                 185                 190         


Tyr Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp 
        195                 200                 205             


Val Ala Ser Thr Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Leu Ile Lys Tyr Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Met Asn 
                245                 250                 255     


Phe Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala 
        275                 280                 285             


Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Lys Arg Tyr Val Glu His His Glu Asp Leu Glu Lys Leu 
                325                 330                 335     


Lys Glu Phe Ile Lys Ala Asn Lys Ser Glu Leu Tyr His Asp Ile Phe 
            340                 345                 350         


Lys Asp Lys Asn Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val 
        355                 360                 365             


Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile 
    370                 375                 380                 


Asp Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Lys Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Val Arg Lys Asp Ser Arg Phe Ala 
    450                 455                 460                 


Trp Ala Glu Tyr Arg Ser Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp 
465                 470                 475                 480 


Lys Val Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met 
                485                 490                 495     


Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser His Val Tyr Glu Thr Tyr Ala Val Tyr Asn Glu Leu Thr Lys Ile 
        515                 520                 525             


Lys Tyr Val Asn Glu Gln Gly Lys Glu Ser Phe Phe Asp Ser Asn Met 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr 
545                 550                 555                 560 


Lys Glu Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu Tyr Arg 
                565                 570                 575     


Ile Lys Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ala Phe 
        595                 600                 605             


Leu Asp Asp Lys Val Asn Glu Glu Val Ile Glu Asp Ile Ile Lys Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Lys Asp Met Ile His Glu Arg Leu Gln Lys 
625                 630                 635                 640 


Tyr Ser Asp Ile Phe Thr Ala Asn Gln Leu Lys Lys Leu Glu Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Ser Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Thr Leu 
    690                 695                 700                 


Pro Phe Lys Gln Ile Ile Gln Lys Ser Gln Val Val Gly Asp Val Asp 
705                 710                 715                 720 


Asp Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Arg Gly Arg Ser Gln Ser Gln Gln Arg Leu Lys Lys 
    770                 775                 780                 


Leu Gln Ser Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn Glu Glu 
785                 790                 795                 800 


Lys Pro Ser Tyr Ile Glu Asp Lys Val Glu Asn Ser His Leu Gln Asn 
                805                 810                 815     


Asp Gln Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr 
            820                 825                 830         


Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val 
    850                 855                 860                 


Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser 
865                 870                 875                 880 


Leu Asp Ile Val Arg Ala Arg Lys Ala Glu Trp Val Arg Leu Tyr Lys 
                885                 890                 895     


Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ala Arg Phe Asn Thr Glu His Asp Glu Asn Asp Lys Val Ile Arg Asp 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys 
                965                 970                 975     


Asp Phe Glu Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Lys Leu Ala Ser Glu  Phe Val Tyr Gly Glu  Tyr Lys Lys 
    1010                 1015                 1020             


Tyr Asp  Ile Arg Lys Phe Ile  Thr Asn Ser Ser Asp  Lys Ala Thr 
    1025                 1030                 1035             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Thr 
    1040                 1045                 1050             


Lys Val  Lys Tyr Ala Asp Gly  Thr Val Phe Glu Arg  Pro Ile Ile 
    1055                 1060                 1065             


Glu Thr  Asn Ala Asp Gly Glu  Ile Ala Trp Asn Lys  Gln Ile Asp 
    1070                 1075                 1080             


Phe Glu  Lys Val Arg Lys Val  Leu Ser Tyr Pro Gln  Val Asn Ile 
    1085                 1090                 1095             


Val Lys  Lys Val Glu Thr Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1100                 1105                 1110             


Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu Ile Pro  Arg Lys Thr 
    1115                 1120                 1125             


Lys Lys  Val Tyr Trp Asp Thr  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1130                 1135                 1140             


Pro Thr  Val Ala Tyr Ser Val  Phe Val Val Ala Asp  Val Glu Lys 
    1145                 1150                 1155             


Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys Glu Leu  Val Gly Ile 
    1160                 1165                 1170             


Ser Ile  Met Glu Arg Ser Phe  Phe Glu Glu Asn Pro  Val Glu Phe 
    1175                 1180                 1185             


Leu Glu  Asn Lys Gly Tyr His  Asn Ile Arg Glu Asp  Lys Leu Ile 
    1190                 1195                 1200             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Phe Glu Gly  Gly Arg Arg 
    1205                 1210                 1215             


Arg Leu  Leu Ala Ser Ala Ser  Glu Leu Gln Lys Gly  Asn Glu Met 
    1220                 1225                 1230             


Val Leu  Pro Gly Tyr Leu Val  Glu Leu Leu Tyr His  Ala His Arg 
    1235                 1240                 1245             


Ala Asp  Asn Phe Asn Ser Thr  Glu Tyr Leu Asn Tyr  Val Ser Glu 
    1250                 1255                 1260             


His Lys  Lys Glu Phe Glu Lys  Val Leu Ser Cys Val  Glu Asp Phe 
    1265                 1270                 1275             


Ala Asn  Leu Tyr Val Asp Val  Glu Lys Asn Leu Ser  Lys Ile Arg 
    1280                 1285                 1290             


Ala Val  Ala Asp Ser Met Asp  Asn Phe Ser Ile Glu  Glu Ile Ser 
    1295                 1300                 1305             


Asn Ser  Phe Ile Asn Leu Leu  Thr Leu Thr Ala Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Asp  Phe Asn Phe Leu Gly  Glu Lys Ile Pro Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Cys Leu  Thr Ala Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1355                 1360                 1365             


Glu Glu  
    1370 


<210>  150
<211>  1371
<212>  PRT
<213>  Streptococcus gallolyticus

<400>  150

Met Thr Glu Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Asn Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ala Lys Val Asp Glu 
                85                  90                  95      


Ser Phe Phe Tyr Arg Leu Asp Glu Ser Phe Leu Thr Thr Asp Asp Lys 
            100                 105                 110         


Asp Phe Glu Arg His Pro Ile Phe Gly Asn Lys Ala Asp Glu Ile Lys 
        115                 120                 125             


Tyr His Gln Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser His Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn 
                165                 170                 175     


Ala Glu Asn Thr Asp Val Gln Lys Leu Phe Glu Ala Phe Val Glu Val 
            180                 185                 190         


Tyr Asp Arg Thr Phe Asp Asp Ser Asn Leu Ser Glu Ile Thr Val Asp 
        195                 200                 205             


Ala Ser Ser Ile Leu Thr Glu Lys Phe Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Leu Ile Lys His Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly 
225                 230                 235                 240 


Asn Leu Val Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Ser 
                245                 250                 255     


Phe Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Glu Leu Ile Gly Lys Ile Gly Asp Glu Tyr Ala 
        275                 280                 285             


Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ala Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Lys Arg Tyr Asn Glu His Gln Val Asp Leu Lys Lys Leu 
                325                 330                 335     


Lys Glu Phe Ile Lys Asn Asn Ala Ser Asp Lys Tyr Asp Glu Ile Phe 
            340                 345                 350         


Asn Asp Lys Asp Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val 
        355                 360                 365             


Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Thr Thr Leu Ser Lys Ile 
    370                 375                 380                 


Asp Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Ala 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Ala Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala 
    450                 455                 460                 


Trp Ala Glu Tyr His Ser Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp 
465                 470                 475                 480 


Glu Ile Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met 
                485                 490                 495     


Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Val Tyr Glu Thr Tyr Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Tyr Val Asn Glu Gln Gly Lys Ser Asn Phe Phe Asp Ala Asn Met 
    530                 535                 540                 


Lys Gln Glu Ile Phe Glu His Val Phe Lys Glu Asn Arg Lys Val Thr 
545                 550                 555                 560 


Lys Asp Lys Phe Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu Tyr Arg 
                565                 570                 575     


Ile Gln Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ser Phe 
        595                 600                 605             


Leu Asp Asp Lys Thr Asn Glu Thr Ile Ile Glu Asp Ile Ile Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Asp Met Ile Arg Gln Arg Leu Gln Lys 
625                 630                 635                 640 


Tyr Ser Asp Ile Phe Thr Pro Gln Gln Leu Lys Lys Leu Glu Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asn Lys Glu Asn Gly Lys Ser Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Ser Asp Asp Thr Leu 
    690                 695                 700                 


Pro Phe Lys Gln Ile Ile Lys Asp Ala Gln Ile Ile Gly Asp Ile Asp 
705                 710                 715                 720 


Asp Val Thr Ser Val Val Arg Glu Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly His Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Arg Gly Arg Asn Gln Ser Gln Gln Arg Leu Lys Lys 
    770                 775                 780                 


Leu Gln Asp Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn Glu Glu 
785                 790                 795                 800 


Lys Pro Ser Tyr Ile Glu Gly Lys Val Glu Asn Asn His Leu Gln Asp 
                805                 810                 815     


Asp Arg Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr 
            820                 825                 830         


Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val 
    850                 855                 860                 


Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser 
865                 870                 875                 880 


Leu Asp Ile Val His Asp Arg Lys Ala Asp Trp Ile Arg Leu Tyr Lys 
                885                 890                 895     


Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Thr Glu Asn Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ser Arg Phe Asn Thr Glu Arg Asp Glu Asn Asp Lys Val Ile Arg Asn 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys 
                965                 970                 975     


Asp Phe Lys Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Lys Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Lys Lys 
    1010                 1015                 1020             


Tyr Asp  Ile Arg Lys Phe Ile  Thr Ser Ser Gly Asp  Lys Ala Thr 
    1025                 1030                 1035             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Arg 
    1040                 1045                 1050             


Val Ile  Arg Tyr Ser Asn Gly  Lys Val Val Val Arg  Pro Val Ile 
    1055                 1060                 1065             


Glu Cys  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Gln Thr 
    1070                 1075                 1080             


Asp Phe  Glu Lys Val Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Val Glu Thr  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Pro Lys Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Lys Phe Arg Trp Asp  Thr Pro Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Asn Ile Ala Tyr Ser  Val Phe Val Ile Ala  Asp Val Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ala Lys Lys Leu  Lys Thr Val Lys Glu  Leu Val Gly 
    1160                 1165                 1170             


Ile Ser  Ile Met Glu Arg Ser  Ser Phe Glu Glu Asn  Pro Val Val 
    1175                 1180                 1185             


Phe Leu  Glu Lys Lys Gly Tyr  Gln Asn Val Gln Glu  Asp Asn Leu 
    1190                 1195                 1200             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Phe Glu  Gly Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Ser Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Val Val  Leu Ser Arg His Leu  Val Glu Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Arg Val  Asn Ser Phe Asn Asn  Ser Glu His Leu Lys  Tyr Val Ser 
    1250                 1255                 1260             


Glu His  Lys Lys Glu Phe Gly  Glu Val Leu Ser Cys  Val Glu Asn 
    1265                 1270                 1275             


Phe Ala  Lys Ser Tyr Val Asp  Val Glu Lys Asn Leu  Gly Lys Ile 
    1280                 1285                 1290             


Arg Ala  Val Ala Asp Lys Ile  Asp Thr Phe Ser Ile  Glu Asp Ile 
    1295                 1300                 1305             


Ser Ile  Ser Phe Val Asn Leu  Leu Thr Leu Thr Ala  Leu Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Asn Phe Leu  Gly Glu Lys Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Thr  Ser Thr Lys Glu Cys  Leu Asn Ala Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1355                 1360                 1365             


Gly Glu  Glu 
    1370     


<210>  151
<211>  1372
<212>  PRT
<213>  Streptococcus gallolyticus

<400>  151

Met Thr Lys Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Asn Glu Ile Ala Lys Val Asp Glu 
                85                  90                  95      


Ser Phe Phe Gln Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys 
            100                 105                 110         


Thr Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala 
        115                 120                 125             


Tyr His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn 
                165                 170                 175     


Ala Glu Asn Thr Asp Val Gln Lys Ile Phe Ala Asp Phe Val Gly Val 
            180                 185                 190         


Tyr Asn Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp 
        195                 200                 205             


Val Ala Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Leu Ile Lys Tyr Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn 
                245                 250                 255     


Phe Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala 
        275                 280                 285             


Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Lys Arg Tyr Val Glu His His Glu Asp Leu Glu Lys Leu 
                325                 330                 335     


Lys Glu Phe Ile Lys Ala Asn Lys Ser Glu Leu Tyr His Asp Ile Phe 
            340                 345                 350         


Lys Asp Lys Asn Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val 
        355                 360                 365             


Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Ile Leu Ser Lys Ile 
    370                 375                 380                 


Lys Ile Asp Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp 
385                 390                 395                 400 


Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
                405                 410                 415     


Ile His Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr 
            420                 425                 430         


Tyr Pro Phe Leu Lys Glu Lys Gln Asp Arg Ile Glu Lys Ile Leu Thr 
        435                 440                 445             


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Arg Lys Asp Ser Arg 
    450                 455                 460                 


Phe Ala Trp Ala Glu Tyr Arg Ser Asp Glu Lys Ile Thr Pro Trp Asn 
465                 470                 475                 480 


Phe Asp Lys Val Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr 
                485                 490                 495     


Arg Met Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro 
            500                 505                 510         


Lys His Ser His Val Tyr Glu Thr Tyr Ala Val Tyr Asn Glu Leu Thr 
        515                 520                 525             


Lys Ile Lys Tyr Val Asn Glu Gln Gly Lys Glu Ser Phe Phe Asp Ser 
    530                 535                 540                 


Asn Met Lys Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys 
545                 550                 555                 560 


Val Thr Lys Glu Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu 
                565                 570                 575     


Tyr Arg Ile Lys Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe 
            580                 585                 590         


Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys 
        595                 600                 605             


Ala Phe Leu Asp Asp Lys Val Asn Glu Glu Val Ile Glu Asp Ile Ile 
    610                 615                 620                 


Lys Thr Leu Thr Leu Phe Glu Asp Lys Asp Met Ile His Glu Arg Leu 
625                 630                 635                 640 


Gln Lys Tyr Ser Asp Ile Phe Thr Ala Asn Gln Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn 
            660                 665                 670         


Gly Ile Arg Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Tyr Leu Ile 
        675                 680                 685             


Asp Asp Gly Ser Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp 
    690                 695                 700                 


Thr Leu Pro Phe Lys Gln Ile Ile Gln Lys Ser Gln Val Val Gly Asp 
705                 710                 715                 720 


Val Asp Asp Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Lys Val Met Gly Gly Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Asn Arg Gly Arg Ser Gln Ser Gln Gln Arg Leu 
    770                 775                 780                 


Lys Lys Leu Gln Asn Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn 
785                 790                 795                 800 


Glu Glu Lys Pro Ser Tyr Ile Glu Asp Lys Val Glu Asn Ser His Leu 
                805                 810                 815     


Gln Asn Asp Gln Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met 
            820                 825                 830         


Tyr Thr Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile 
        835                 840                 845             


Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn 
    850                 855                 860                 


Arg Val Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val 
865                 870                 875                 880 


Pro Ser Leu Asp Ile Val Arg Ala Arg Lys Ala Glu Trp Val Arg Leu 
                885                 890                 895     


Tyr Lys Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys 
            900                 905                 910         


Ala Glu Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys 
        915                 920                 925             


Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile 
    930                 935                 940                 


Leu Asp Ala Arg Phe Asn Thr Glu His Asp Glu Asn Asp Lys Val Ile 
945                 950                 955                 960 


Arg Asp Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe 
                965                 970                 975     


Arg Lys Asp Phe Glu Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His 
            980                 985                 990         


His Ala His Asp Ala Tyr Leu Asn  Ala Val Val Gly Thr  Ala Leu Leu 
        995                 1000                 1005             


Lys Lys  Tyr Pro Lys Leu Ala  Ser Glu Phe Val Tyr  Gly Glu Tyr 
    1010                 1015                 1020             


Lys Lys  Tyr Asp Ile Arg Lys  Phe Ile Thr Asn Ser  Ser Asp Lys 
    1025                 1030                 1035             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Leu Met  Asn Phe Phe 
    1040                 1045                 1050             


Lys Thr  Lys Val Lys Tyr Ala  Asp Gly Thr Val Phe  Glu Arg Pro 
    1055                 1060                 1065             


Ile Ile  Glu Thr Asn Ala Asp  Gly Glu Ile Ala Trp  Asn Lys Gln 
    1070                 1075                 1080             


Ile Asp  Phe Glu Lys Val Arg  Lys Val Leu Ser Tyr  Pro Gln Val 
    1085                 1090                 1095             


Asn Ile  Val Lys Lys Val Glu  Thr Gln Thr Gly Gly  Phe Ser Lys 
    1100                 1105                 1110             


Glu Ser  Ile Leu Pro Lys Gly  Asp Ser Asp Lys Leu  Ile Pro Arg 
    1115                 1120                 1125             


Lys Thr  Lys Lys Val Tyr Trp  Asp Thr Lys Lys Tyr  Gly Gly Phe 
    1130                 1135                 1140             


Asp Ser  Pro Thr Val Ala Tyr  Ser Val Phe Val Val  Ala Asp Val 
    1145                 1150                 1155             


Glu Lys  Gly Lys Ala Lys Lys  Leu Lys Thr Val Lys  Glu Leu Val 
    1160                 1165                 1170             


Gly Ile  Ser Ile Met Glu Arg  Ser Phe Phe Glu Glu  Asn Pro Val 
    1175                 1180                 1185             


Glu Phe  Leu Glu Asn Lys Gly  Tyr His Asn Ile Arg  Glu Asp Lys 
    1190                 1195                 1200             


Leu Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Phe  Glu Gly Gly 
    1205                 1210                 1215             


Arg Arg  Arg Leu Leu Ala Ser  Ala Ser Glu Leu Gln  Lys Gly Asn 
    1220                 1225                 1230             


Glu Met  Val Leu Pro Gly Tyr  Leu Val Glu Leu Leu  Tyr His Ala 
    1235                 1240                 1245             


His Arg  Ala Asp Asn Phe Asn  Ser Thr Glu Tyr Leu  Asn Tyr Val 
    1250                 1255                 1260             


Ser Glu  His Lys Lys Glu Phe  Glu Lys Val Leu Ser  Cys Val Glu 
    1265                 1270                 1275             


Asp Phe  Ala Asn Leu Tyr Val  Asp Val Glu Lys Asn  Leu Ser Lys 
    1280                 1285                 1290             


Ile Arg  Ala Val Ala Asp Ser  Met Asp Asn Phe Ser  Ile Glu Glu 
    1295                 1300                 1305             


Ile Ser  Asn Ser Phe Ile Asn  Leu Leu Thr Leu Thr  Ala Leu Gly 
    1310                 1315                 1320             


Ala Pro  Ala Asp Phe Asn Phe  Leu Gly Glu Lys Ile  Pro Arg Lys 
    1325                 1330                 1335             


Arg Tyr  Thr Ser Thr Lys Glu  Cys Leu Asn Ala Thr  Leu Ile His 
    1340                 1345                 1350             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Lys 
    1355                 1360                 1365             


Leu Gly  Glu Glu 
    1370         


<210>  152
<211>  1375
<212>  PRT
<213>  Streptococcus infantarius

<400>  152

Met Glu Lys Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Val Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Lys Glu Met Thr Lys Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Glu Ser Phe Leu Thr Asp Asp Asp Lys Thr 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Gln Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Asn Val Phe Val Glu Thr Tyr 
            180                 185                 190         


Asp Lys Ile Val Asp Glu Ser His Leu Ser Glu Ile Glu Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Lys Gln Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Val Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ile Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Val Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ile Asn Lys Leu Lys Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Lys Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Thr Ile Leu Thr Lys Ile Asp 
    370                 375                 380                 


Asp Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Asp Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ser Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Ala Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asp Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Asn Tyr His Ser Asp Glu Pro Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Val Val Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


His Val Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ser Phe Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Ala Lys Leu Leu Ser Tyr Leu Asn Asn Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Asn Asp Leu Ile Gly Leu Asp Lys Asp Ser Lys Ser Phe Asn Ala Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asp Lys Thr Asn Gly Gln Ile Ile Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Asp Met Ile His Glu Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Phe Phe Thr Ser Gln Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Phe Leu Ile Asp Asp Gly 
        675                 680                 685             


His Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Glu Ser Leu Ser 
    690                 695                 700                 


Phe Lys Thr Ile Ile Gln Glu Ala Gln Val Val Gly Asp Val Asp Asp 
705                 710                 715                 720 


Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gly Tyr Gly Arg Asn Lys Ser Asn Gln Arg Leu Lys Arg Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Glu Phe Gly Ser Asp Ile Leu Ser Lys Lys Lys 
785                 790                 795                 800 


Pro Ser Tyr Val Asp Ser Lys Val Glu Asn Ser His Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Glu Glu Leu Asp Ile Asp Arg Leu Ser Asp Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile 
865                 870                 875                 880 


Glu Ile Val Arg Asn Arg Arg Ser Tyr Trp Tyr Lys Leu Tyr Lys Ser 
                885                 890                 895     


Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala 
    930                 935                 940                 


Arg Phe Asn Thr Lys Arg Asp Glu Asn Asp Lys Val Ile Arg Asp Val 
945                 950                 955                 960 


Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys Glu 
                965                 970                 975     


Phe Lys Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Gly Thr Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Thr Pro Glu Phe  Val Tyr Gly Glu Tyr  Lys Lys Tyr 
    1010                 1015                 1020             


Asp Val  Arg Lys Leu Ile Ala  Lys Ser Ser Asp Asp  Tyr Ser Glu 
    1025                 1030                 1035             


Met Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met 
    1040                 1045                 1050             


Asn Phe  Phe Lys Thr Glu Val  Lys Tyr Ala Asp Gly  Arg Val Phe 
    1055                 1060                 1065             


Glu Arg  Pro Asp Ile Glu Thr  Asn Ala Asp Gly Glu  Val Val Trp 
    1070                 1075                 1080             


Asn Lys  Gln Lys Asp Phe Asp  Ile Val Arg Lys Val  Leu Ser Tyr 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Ala Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Ser Lys Gly Asp Ser  Asp Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Thr Lys Lys  Val Tyr Trp Asn Thr  Lys Lys Tyr 
    1130                 1135                 1140             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1145                 1150                 1155             


Ala Asp  Ile Glu Lys Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys 
    1160                 1165                 1170             


Glu Leu  Val Gly Ile Ser Ile  Met Glu Arg Ser Phe  Phe Glu Glu 
    1175                 1180                 1185             


Asn Pro  Val Ser Phe Leu Glu  Lys Lys Gly Tyr His  Asn Val Gln 
    1190                 1195                 1200             


Glu Asp  Lys Leu Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Phe 
    1205                 1210                 1215             


Glu Gly  Gly Arg Arg Arg Leu  Leu Ala Ser Ala Thr  Glu Leu Gln 
    1220                 1225                 1230             


Lys Gly  Asn Glu Val Met Leu  Pro Ala His Leu Val  Glu Leu Leu 
    1235                 1240                 1245             


Tyr His  Ala His Arg Ile Asp  Ser Phe Asn Ser Thr  Glu His Leu 
    1250                 1255                 1260             


Lys Tyr  Val Ser Glu His Lys  Lys Glu Phe Glu Lys  Val Leu Ser 
    1265                 1270                 1275             


Cys Val  Glu Asn Phe Ser Asn  Leu Tyr Val Asp Val  Glu Lys Asn 
    1280                 1285                 1290             


Leu Ser  Lys Val Arg Ala Ala  Ala Glu Ser Met Thr  Asn Phe Ser 
    1295                 1300                 1305             


Leu Glu  Glu Ile Ser Ala Ser  Phe Ile Asn Leu Leu  Thr Leu Thr 
    1310                 1315                 1320             


Ala Leu  Gly Ala Pro Ala Asp  Phe Asn Phe Leu Gly  Glu Lys Ile 
    1325                 1330                 1335             


Pro Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Cys Leu  Ser Ala Thr 
    1340                 1345                 1350             


Leu Ile  His Gln Ser Val Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1355                 1360                 1365             


Leu Ser  Lys Leu Gly Glu Glu  
    1370                 1375 


<210>  153
<211>  1368
<212>  PRT
<213>  Streptococcus iniae

<400>  153

Met Arg Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Arg Ile Gln Gly Thr Thr Asp Arg Thr Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Asn Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Thr Arg Arg Arg Tyr Thr Arg Arg Lys Tyr Arg Ile Lys 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ser Ser Glu Met Asn Glu Leu Asp Ile Ala 
                85                  90                  95      


Phe Phe Pro Arg Leu Ser Glu Ser Phe Leu Val Ser Asp Asp Lys Glu 
            100                 105                 110         


Phe Glu Asn His Pro Ile Phe Gly Asn Leu Lys Asp Glu Ile Thr Tyr 
        115                 120                 125             


His Asn Asp Tyr Pro Thr Ile Tyr His Leu Arg Gln Thr Leu Ala Asp 
    130                 135                 140                 


Ser Asp Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asn Leu Asp Ser 
                165                 170                 175     


Glu Asn Thr Asp Val His Val Leu Phe Leu Asn Leu Val Asn Ile Tyr 
            180                 185                 190         


Asn Asn Leu Phe Glu Glu Asp Ile Val Glu Thr Ala Ser Ile Asp Ala 
        195                 200                 205             


Glu Lys Ile Leu Thr Ser Lys Thr Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Glu Ile Pro Asn Gln Lys Arg Asn Met Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Val Ser Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Glu Leu Leu Glu Asp Ala Lys Leu Gln Ile Ser Lys Asp Ser Tyr Glu 
            260                 265                 270         


Glu Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ile Ala Ala Lys Lys Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Ile Thr Val Lys Gly Ala Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Gln Arg Tyr Glu Glu His Gln Gln Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Asn Leu Val Lys Lys Gln Ile Pro Glu Lys Tyr Lys Glu Ile Phe Asp 
            340                 345                 350         


Asn Lys Glu Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Tyr Ile Lys Pro Ile Leu Leu Lys Leu Asp 
    370                 375                 380                 


Gly Thr Glu Lys Leu Ile Ser Lys Leu Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Asn Glu Leu Lys Ala Ile Ile Arg Arg Gln Glu Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Lys Lys Ile Glu Lys Leu Phe Thr Phe Lys Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Asn Gly Gln Ser Ser Phe Ala Trp 
    450                 455                 460                 


Leu Lys Arg Gln Ser Asn Glu Ser Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Gln Glu Ala Ser Ala Arg Ala Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Thr Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Met Phe Met Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Gln Thr Glu Gly Met Lys Arg Pro Val Phe Leu Ser Ser Glu Asp 
    530                 535                 540                 


Lys Glu Glu Ile Val Asn Leu Leu Phe Lys Lys Glu Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Glu Tyr Phe Ser Lys Met Lys Cys Phe His 
                565                 570                 575     


Thr Val Thr Ile Leu Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Phe Lys Asp Lys Ala Phe Leu Asp 
        595                 600                 605             


Asp Glu Ala Asn Gln Asp Ile Leu Glu Glu Ile Val Trp Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Gln Ala Met Ile Glu Arg Arg Leu Val Lys Tyr Ala 
625                 630                 635                 640 


Asp Val Phe Glu Lys Ser Val Leu Lys Lys Leu Lys Lys Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Gln Lys Leu Ile Asn Gly Ile Lys Asp 
            660                 665                 670         


Lys Gln Thr Gly Lys Thr Ile Leu Gly Phe Leu Lys Asp Asp Gly Val 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Ser Ser Leu Asp Phe 
    690                 695                 700                 


Ala Lys Ile Ile Lys Asn Glu Gln Glu Lys Thr Ile Lys Asn Glu Ser 
705                 710                 715                 720 


Leu Glu Glu Thr Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Ile Val Lys Ile Met 
            740                 745                 750         


Gly Gln Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Ser Thr Met Gln Gly Ile Lys Asn Ser Arg Gln Arg Leu Arg Lys Leu 
    770                 775                 780                 


Glu Glu Val His Lys Asn Thr Gly Ser Lys Ile Leu Lys Glu Tyr Asn 
785                 790                 795                 800 


Val Ser Asn Thr Gln Leu Gln Ser Asp Arg Leu Tyr Leu Tyr Leu Leu 
                805                 810                 815     


Gln Asp Gly Lys Asp Met Tyr Thr Gly Lys Glu Leu Asp Tyr Asp Asn 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Thr Val Leu Thr Thr Gln Ala Ser Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Asn Ile Glu Thr Val Asn Lys Met Lys 
865                 870                 875                 880 


Ser Phe Trp Tyr Lys Gln Leu Lys Ser Gly Ala Ile Ser Gln Arg Lys 
                885                 890                 895     


Phe Asp His Leu Thr Lys Ala Glu Arg Gly Ala Leu Ser Asp Phe Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Phe Asn Ser Asn Leu Thr 
    930                 935                 940                 


Glu Asp Ser Lys Ser Asn Arg Asn Val Lys Ile Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Met Val Ser Asp Phe Arg Lys Asp Phe Gly Phe Tyr Lys Leu Arg 
                965                 970                 975     


Glu Val Asn Asp Tyr His His Ala Gln Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Leu Lys Lys  Tyr Pro Lys Leu Glu  Ala Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys His  Tyr Asp Leu Ala Lys  Leu Met Ile 
    1010                 1015                 1020             


Gln Pro  Asp Ser Ser Leu Gly  Lys Ala Thr Thr Arg  Met Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Lys Glu Ile  Lys Leu Ala 
    1040                 1045                 1050             


Asp Asp  Thr Ile Phe Thr Arg  Pro Gln Ile Glu Val  Asn Thr Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Val Lys Asp Met  Gln Thr Ile 
    1070                 1075                 1080             


Arg Lys  Val Met Ser Tyr Pro  Gln Val Asn Ile Val  Met Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Trp Pro Lys 
    1100                 1105                 1110             


Gly Asp  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Ser  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Ile Ile Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Ile Ala  Lys Gly Lys Thr Gln  Lys Leu Lys 
    1145                 1150                 1155             


Thr Ile  Lys Glu Leu Val Gly  Ile Lys Ile Met Glu  Gln Asp Glu 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Ile Ala  Phe Leu Glu Lys Lys  Gly Tyr Gln 
    1175                 1180                 1185             


Asp Ile  Gln Thr Ser Ser Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Leu Leu Ala  Ser Ala Lys 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Asn  Lys Tyr Val 
    1220                 1225                 1230             


Lys Phe  Leu Tyr Leu Ala Ser  His Tyr Thr Lys Phe  Thr Gly Lys 
    1235                 1240                 1245             


Glu Glu  Asp Arg Glu Lys Lys  Arg Ser Tyr Val Glu  Ser His Leu 
    1250                 1255                 1260             


Tyr Tyr  Phe Asp Glu Ile Met  Gln Ile Ile Val Glu  Tyr Ser Asn 
    1265                 1270                 1275             


Arg Tyr  Ile Leu Ala Asp Ser  Asn Leu Ile Lys Ile  Gln Asn Leu 
    1280                 1285                 1290             


Tyr Lys  Glu Lys Asp Asn Phe  Ser Ile Glu Glu Gln  Ala Ile Asn 
    1295                 1300                 1305             


Met Leu  Asn Leu Phe Thr Phe  Thr Asp Leu Gly Ala  Pro Ser Ala 
    1310                 1315                 1320             


Phe Lys  Phe Phe Asn Gly Asp  Ile Asp Arg Lys Arg  Tyr Ser Ser 
    1325                 1330                 1335             


Thr Asn  Glu Ile Ile Asn Ser  Thr Leu Ile Tyr Gln  Ser Pro Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Lys Leu  Gly Gly Lys 
    1355                 1360                 1365             


<210>  154
<211>  1273
<212>  PRT
<213>  Streptococcus iniae


<220>
<221>  misc_feature
<222>  (1267)..(1267)
<223>  Xaa can be any naturally occurring amino acid

<400>  154

Met Arg Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Arg Ile Gln Gly Thr Thr Asp Arg Thr Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Asn Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Thr Arg Arg Arg Tyr Thr Arg Arg Lys Tyr Arg Ile Lys 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ser Ser Glu Met Asn Glu Leu Asp Ile Ala 
                85                  90                  95      


Phe Phe Pro Arg Leu Ser Glu Ser Phe Leu Val Ser Asp Asp Lys Glu 
            100                 105                 110         


Phe Glu Asn His Pro Ile Phe Gly Asn Leu Lys Asp Glu Ile Thr Tyr 
        115                 120                 125             


His Asn Asp Tyr Pro Thr Ile Tyr His Leu Arg Gln Thr Leu Ala Asp 
    130                 135                 140                 


Ser Asp Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asn Leu Asp Ser 
                165                 170                 175     


Glu Asn Thr Asp Val His Val Leu Phe Leu Asn Leu Val Asn Ile Tyr 
            180                 185                 190         


Asn Asn Leu Phe Glu Glu Asp Ile Val Glu Thr Ala Ser Ile Asp Ala 
        195                 200                 205             


Glu Lys Ile Leu Thr Ser Lys Thr Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Glu Ile Pro Asn Gln Lys Arg Asn Met Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Val Ser Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Glu Leu Leu Glu Asp Ala Lys Leu Gln Ile Ser Lys Asp Ser Tyr Glu 
            260                 265                 270         


Glu Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ile Ala Ala Lys Lys Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Ile Thr Val Lys Gly Ala Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Gln Arg Tyr Glu Glu His Gln Gln Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Asn Leu Val Lys Lys Gln Ile Pro Glu Lys Tyr Lys Glu Ile Phe Asp 
            340                 345                 350         


Asn Lys Glu Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Tyr Ile Lys Pro Ile Leu Leu Lys Leu Asp 
    370                 375                 380                 


Gly Thr Glu Lys Leu Ile Ser Lys Leu Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Asn Glu Leu Lys Ala Ile Ile Arg Arg Gln Glu Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Lys Lys Ile Glu Lys Leu Phe Thr Phe Lys Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Asn Gly Gln Ser Ser Phe Ala Trp 
    450                 455                 460                 


Leu Lys Arg Gln Ser Asn Glu Ser Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Gln Glu Ala Ser Ala Arg Ala Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Thr Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Met Phe Met Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Gln Thr Glu Gly Met Lys Arg Pro Val Phe Leu Ser Ser Glu Asp 
    530                 535                 540                 


Lys Glu Glu Ile Val Asn Leu Leu Phe Lys Lys Glu Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Glu Tyr Phe Ser Lys Met Lys Cys Phe His 
                565                 570                 575     


Thr Val Thr Ile Leu Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Phe Lys Asp Lys Ala Phe Leu Asp 
        595                 600                 605             


Asp Glu Ala Asn Gln Asp Ile Leu Glu Glu Ile Val Trp Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Gln Ala Met Ile Glu Arg Arg Leu Val Lys Tyr Ala 
625                 630                 635                 640 


Asp Val Phe Glu Lys Ser Val Leu Lys Lys Leu Lys Lys Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Gln Lys Leu Ile Asn Gly Ile Lys Asp 
            660                 665                 670         


Lys Gln Thr Gly Lys Thr Ile Leu Gly Phe Leu Lys Asp Asp Gly Val 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Ser Ser Leu Asp Phe 
    690                 695                 700                 


Ala Lys Ile Ile Lys Asn Glu Gln Glu Lys Thr Ile Lys Asn Glu Ser 
705                 710                 715                 720 


Leu Glu Glu Thr Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Ile Val Lys Ile Met 
            740                 745                 750         


Gly Gln Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Ser Thr Met Gln Gly Ile Lys Asn Ser Arg Gln Arg Leu Arg Lys Leu 
    770                 775                 780                 


Glu Glu Val His Lys Asn Thr Gly Ser Lys Ile Leu Lys Glu Tyr Asn 
785                 790                 795                 800 


Val Ser Asn Thr Gln Leu Gln Ser Asp Arg Leu Tyr Leu Tyr Leu Leu 
                805                 810                 815     


Gln Asp Gly Lys Asp Met Tyr Thr Gly Lys Glu Leu Asp Tyr Asp Asn 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Thr Val Leu Thr Thr Gln Ala Ser Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Asn Ile Glu Thr Val Asn Lys Met Lys 
865                 870                 875                 880 


Ser Phe Trp Tyr Lys Gln Leu Lys Ser Gly Ala Ile Ser Gln Arg Lys 
                885                 890                 895     


Phe Asp His Leu Thr Lys Ala Glu Arg Gly Ala Leu Ser Asp Phe Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Phe Asn Ser Asn Leu Thr 
    930                 935                 940                 


Glu Asp Ser Lys Ser Asn Arg Asn Val Lys Ile Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Met Val Ser Asp Phe Arg Lys Asp Phe Gly Phe Tyr Lys Leu Arg 
                965                 970                 975     


Glu Val Asn Asp Tyr His His Ala Gln Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Leu Lys Lys  Tyr Pro Lys Leu Glu  Ala Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys His  Tyr Asp Leu Ala Lys  Leu Met Ile 
    1010                 1015                 1020             


Gln Pro  Asp Ser Ser Leu Gly  Lys Ala Thr Thr Arg  Met Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Lys Glu Ile  Lys Leu Ala 
    1040                 1045                 1050             


Asp Asp  Thr Ile Phe Thr Arg  Pro Gln Ile Glu Val  Asn Thr Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Val Lys Asp Met  Gln Thr Ile 
    1070                 1075                 1080             


Arg Lys  Val Met Ser Tyr Pro  Gln Val Asn Ile Val  Met Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Trp Pro Lys 
    1100                 1105                 1110             


Gly Asp  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Ser  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Ile Ile Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Ile Ala  Lys Gly Lys Thr Gln  Lys Leu Lys 
    1145                 1150                 1155             


Thr Ile  Lys Glu Leu Val Gly  Ile Lys Ile Met Glu  Gln Asp Glu 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Ile Ala  Phe Leu Glu Lys Lys  Gly Tyr Gln 
    1175                 1180                 1185             


Asp Ile  Gln Thr Ser Ser Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Leu Leu Ala  Ser Ala Lys 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Asn  Lys Tyr Val 
    1220                 1225                 1230             


Lys Phe  Leu Tyr Leu Ala Ser  His Tyr Thr Lys Phe  Thr Gly Lys 
    1235                 1240                 1245             


Glu Glu  Asp Arg Glu Lys Lys  Arg Ser Tyr Val Glu  Ser His Leu 
    1250                 1255                 1260             


Tyr Tyr  Phe Xaa Glu Val Lys  Ser Ser Phe 
    1265                 1270             


<210>  155
<211>  1267
<212>  PRT
<213>  Streptococcus iniae


<220>
<221>  misc_feature
<222>  (1265)..(1265)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1267)..(1267)
<223>  Xaa can be any naturally occurring amino acid

<400>  155

Met Arg Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Arg Ile Gln Gly Thr Thr Asp Arg Thr Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Asn Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Thr Arg Arg Arg Tyr Thr Arg Arg Lys Tyr Arg Ile Lys 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ser Ser Glu Met Asn Glu Leu Asp Ile Ala 
                85                  90                  95      


Phe Phe Pro Arg Leu Ser Glu Ser Phe Leu Val Ser Asp Asp Lys Glu 
            100                 105                 110         


Phe Glu Asn His Pro Ile Phe Gly Asn Leu Lys Asp Glu Ile Thr Tyr 
        115                 120                 125             


His Asn Asp Tyr Pro Thr Ile Tyr His Leu Arg Gln Thr Leu Ala Asp 
    130                 135                 140                 


Ser Asp Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asn Leu Asp Ser 
                165                 170                 175     


Glu Asn Thr Asp Val His Val Leu Phe Leu Asn Leu Val Asn Ile Tyr 
            180                 185                 190         


Asn Asn Leu Phe Glu Glu Asp Ile Val Glu Thr Ala Ser Ile Asp Ala 
        195                 200                 205             


Glu Lys Ile Leu Thr Ser Lys Thr Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Glu Ile Pro Asn Gln Lys Arg Asn Met Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Val Ser Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Glu Leu Leu Glu Asp Ala Lys Leu Gln Ile Ser Lys Asp Ser Tyr Glu 
            260                 265                 270         


Glu Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ile Ala Ala Lys Lys Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Ile Thr Val Lys Gly Ala Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Gln Arg Tyr Glu Glu His Gln Gln Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Asn Leu Val Lys Lys Gln Ile Pro Glu Lys Tyr Lys Glu Ile Phe Asp 
            340                 345                 350         


Asn Lys Glu Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Tyr Ile Lys Pro Ile Leu Leu Lys Leu Asp 
    370                 375                 380                 


Gly Thr Glu Lys Leu Ile Ser Lys Leu Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Asn Glu Leu Lys Ala Ile Ile Arg Arg Gln Glu Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Lys Lys Ile Glu Lys Leu Phe Thr Phe Lys Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Asn Gly Gln Ser Ser Phe Ala Trp 
    450                 455                 460                 


Leu Lys Arg Gln Ser Asn Glu Ser Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Gln Glu Ala Ser Ala Arg Ala Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Thr Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Met Phe Met Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Gln Thr Glu Gly Met Lys Arg Pro Val Phe Leu Ser Ser Glu Asp 
    530                 535                 540                 


Lys Glu Glu Ile Val Asn Leu Leu Phe Lys Lys Glu Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Glu Tyr Phe Ser Lys Met Lys Cys Phe His 
                565                 570                 575     


Thr Val Thr Ile Leu Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Phe Lys Asp Lys Ala Phe Leu Asp 
        595                 600                 605             


Asp Glu Ala Asn Gln Asp Ile Leu Glu Glu Ile Val Trp Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Gln Ala Met Ile Glu Arg Arg Leu Val Lys Tyr Ala 
625                 630                 635                 640 


Asp Val Phe Glu Lys Ser Val Leu Lys Lys Leu Lys Lys Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Gln Lys Leu Ile Asn Gly Ile Lys Asp 
            660                 665                 670         


Lys Gln Thr Gly Lys Thr Ile Leu Gly Phe Leu Lys Asp Asp Gly Val 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Ser Ser Leu Asp Phe 
    690                 695                 700                 


Ala Lys Ile Ile Lys Asn Glu Gln Glu Lys Thr Ile Lys Asn Glu Ser 
705                 710                 715                 720 


Leu Glu Glu Thr Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Ile Val Lys Ile Met 
            740                 745                 750         


Gly Gln Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Ser Thr Met Gln Gly Ile Lys Asn Ser Arg Gln Arg Leu Arg Lys Leu 
    770                 775                 780                 


Glu Glu Val His Lys Asn Thr Gly Ser Lys Ile Leu Lys Glu Tyr Asn 
785                 790                 795                 800 


Val Ser Asn Thr Gln Leu Gln Ser Asp Arg Leu Tyr Leu Tyr Leu Leu 
                805                 810                 815     


Gln Asp Gly Lys Asp Met Tyr Thr Gly Lys Glu Leu Asp Tyr Asp Asn 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Thr Val Leu Thr Thr Gln Ala Ser Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Asn Ile Glu Thr Val Asn Lys Met Lys 
865                 870                 875                 880 


Ser Phe Trp Tyr Lys Gln Leu Lys Ser Gly Ala Ile Ser Gln Arg Lys 
                885                 890                 895     


Phe Asp His Leu Thr Lys Ala Glu Arg Gly Ala Leu Ser Asp Phe Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Phe Asn Ser Asn Leu Thr 
    930                 935                 940                 


Glu Asp Ser Lys Ser Asn Arg Asn Val Lys Ile Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Met Val Ser Asp Phe Arg Lys Asp Phe Gly Phe Tyr Lys Leu Arg 
                965                 970                 975     


Glu Val Asn Asp Tyr His His Ala Gln Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Leu Lys Lys  Tyr Pro Lys Leu Glu  Ala Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys His  Tyr Asp Leu Ala Lys  Leu Met Ile 
    1010                 1015                 1020             


Gln Pro  Asp Ser Ser Leu Gly  Lys Ala Thr Thr Arg  Met Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Lys Glu Ile  Lys Leu Ala 
    1040                 1045                 1050             


Asp Asp  Thr Ile Phe Thr Arg  Pro Gln Ile Glu Val  Asn Thr Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Val Lys Asp Met  Gln Thr Ile 
    1070                 1075                 1080             


Arg Lys  Val Met Ser Tyr Pro  Gln Val Asn Ile Val  Met Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Trp Pro Lys 
    1100                 1105                 1110             


Gly Asp  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Ser  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Ile Ile Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Ile Ala  Lys Gly Lys Thr Gln  Lys Leu Lys 
    1145                 1150                 1155             


Thr Ile  Lys Glu Leu Val Gly  Ile Lys Ile Met Glu  Gln Asp Glu 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Ile Ala  Phe Leu Glu Lys Lys  Gly Tyr Gln 
    1175                 1180                 1185             


Asp Ile  Gln Thr Ser Ser Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Leu Leu Ala  Ser Ala Lys 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Asn  Lys Tyr Val 
    1220                 1225                 1230             


Lys Phe  Leu Tyr Leu Ala Ser  His Tyr Thr Lys Phe  Thr Gly Lys 
    1235                 1240                 1245             


Glu Glu  Asp Arg Glu Lys Lys  Arg Ser Tyr Val Glu  Ser His Leu 
    1250                 1255                 1260             


Tyr Xaa  Phe Xaa 
    1265         


<210>  156
<211>  200
<212>  PRT
<213>  Streptococcus iniae

<400>  156

Met Glu Gln Asp Glu Phe Glu Lys Asp Pro Ile Ala Phe Leu Glu Lys 
1               5                   10                  15      


Lys Gly Tyr Gln Asp Ile Gln Thr Ser Ser Ile Ile Lys Leu Pro Lys 
            20                  25                  30          


Tyr Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg Leu Leu Ala Ser 
        35                  40                  45              


Ala Lys Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Asn Lys Tyr 
    50                  55                  60                  


Val Lys Phe Leu Tyr Leu Ala Ser His Tyr Thr Lys Phe Thr Gly Lys 
65                  70                  75                  80  


Glu Glu Asp Arg Glu Lys Lys Arg Ser Tyr Val Glu Ser His Leu Tyr 
                85                  90                  95      


Tyr Phe Asp Glu Ile Met Gln Ile Ile Val Glu Tyr Ser Asn Arg Tyr 
            100                 105                 110         


Ile Leu Ala Asp Ser Asn Leu Ile Lys Ile Gln Asn Leu Tyr Lys Glu 
        115                 120                 125             


Lys Asp Asn Phe Ser Ile Glu Glu Gln Ala Ile Asn Met Leu Asn Leu 
    130                 135                 140                 


Phe Thr Phe Thr Asp Leu Gly Ala Pro Ser Ala Phe Lys Phe Phe Asn 
145                 150                 155                 160 


Gly Asp Ile Asp Arg Lys Arg Tyr Ser Ser Thr Asn Glu Ile Ile Asn 
                165                 170                 175     


Ser Thr Leu Ile Tyr Gln Ser Pro Thr Gly Leu Tyr Glu Thr Arg Ile 
            180                 185                 190         


Asp Leu Ser Lys Leu Gly Gly Lys 
        195                 200 


<210>  157
<211>  1281
<212>  PRT
<213>  Streptococcus iniae

<400>  157

Met Arg Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Arg Ile Gln Gly Thr Thr Asp Arg Thr Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Asn Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Thr Arg Arg Arg Tyr Thr Arg Arg Lys Tyr Arg Ile Lys 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ser Ser Glu Met Asn Glu Leu Asp Ile Ala 
                85                  90                  95      


Phe Phe Pro Arg Leu Ser Glu Ser Phe Leu Val Ser Asp Asp Lys Glu 
            100                 105                 110         


Phe Glu Asn His Pro Ile Phe Gly Asn Leu Lys Asp Glu Ile Thr Tyr 
        115                 120                 125             


His Asn Asp Tyr Pro Thr Ile Tyr His Leu Arg Gln Thr Leu Ala Asp 
    130                 135                 140                 


Ser Asp Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asn Leu Asp Ser 
                165                 170                 175     


Glu Asn Thr Asp Val His Val Leu Phe Leu Asn Leu Val Asn Ile Tyr 
            180                 185                 190         


Asn Asn Leu Phe Glu Glu Asp Ile Val Glu Thr Ala Ser Ile Asp Ala 
        195                 200                 205             


Glu Lys Ile Leu Thr Ser Lys Thr Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Glu Ile Pro Asn Gln Lys Arg Asn Met Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Val Ser Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Glu Leu Leu Glu Asp Ala Lys Leu Gln Ile Ser Lys Asp Ser Tyr Glu 
            260                 265                 270         


Glu Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ile Ala Ala Lys Lys Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Ile Thr Val Lys Gly Ala Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Gln Arg Tyr Glu Glu His Gln Gln Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Asn Leu Val Lys Lys Gln Ile Pro Glu Lys Tyr Lys Glu Ile Phe Asp 
            340                 345                 350         


Asn Lys Glu Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Tyr Ile Lys Pro Ile Leu Leu Lys Leu Asp 
    370                 375                 380                 


Gly Thr Glu Lys Leu Ile Ser Lys Leu Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Asn Glu Leu Lys Ala Ile Ile Arg Arg Gln Glu Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Lys Lys Ile Glu Lys Leu Phe Thr Phe Lys Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Asn Gly Gln Ser Ser Phe Ala Trp 
    450                 455                 460                 


Leu Lys Arg Gln Ser Asn Glu Ser Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Gln Glu Ala Ser Ala Arg Ala Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Thr Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Met Phe Met Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Gln Thr Glu Gly Met Lys Arg Pro Val Phe Leu Ser Ser Glu Asp 
    530                 535                 540                 


Lys Glu Glu Ile Val Asn Leu Leu Phe Lys Lys Glu Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Glu Tyr Phe Ser Lys Met Lys Cys Phe His 
                565                 570                 575     


Thr Val Thr Ile Leu Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Phe Lys Asp Lys Ala Phe Leu Asp 
        595                 600                 605             


Asp Glu Ala Asn Gln Asp Ile Leu Glu Glu Ile Val Trp Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Gln Ala Met Ile Glu Arg Arg Leu Val Lys Tyr Ala 
625                 630                 635                 640 


Asp Val Phe Glu Lys Ser Val Leu Lys Lys Leu Lys Lys Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Gln Lys Leu Ile Asn Gly Ile Lys Asp 
            660                 665                 670         


Lys Gln Thr Gly Lys Thr Ile Leu Gly Phe Leu Lys Asp Asp Gly Val 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Ser Ser Leu Asp Phe 
    690                 695                 700                 


Ala Lys Ile Ile Lys Asn Glu Gln Glu Lys Thr Ile Lys Asn Glu Ser 
705                 710                 715                 720 


Leu Glu Glu Thr Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Ile Val Lys Ile Met 
            740                 745                 750         


Gly Gln Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Ser Thr Met Gln Gly Ile Lys Asn Ser Arg Gln Arg Leu Arg Lys Leu 
    770                 775                 780                 


Glu Glu Val His Lys Asn Thr Gly Ser Lys Ile Leu Lys Glu Tyr Asn 
785                 790                 795                 800 


Val Ser Asn Thr Gln Leu Gln Ser Asp Arg Leu Tyr Leu Tyr Leu Leu 
                805                 810                 815     


Gln Asp Gly Lys Asp Met Tyr Thr Gly Lys Glu Leu Asp Tyr Asp Asn 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Thr Val Leu Thr Thr Gln Ala Ser Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Asn Ile Glu Thr Val Asn Lys Met Lys 
865                 870                 875                 880 


Ser Phe Trp Tyr Lys Gln Leu Lys Ser Gly Ala Ile Ser Gln Arg Lys 
                885                 890                 895     


Phe Asp His Leu Thr Lys Ala Glu Arg Gly Ala Leu Ser Asp Phe Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Phe Asn Ser Asn Leu Thr 
    930                 935                 940                 


Glu Asp Ser Lys Ser Asn Arg Asn Val Lys Ile Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Met Val Ser Asp Phe Arg Lys Asp Phe Gly Phe Tyr Lys Leu Arg 
                965                 970                 975     


Glu Val Asn Asp Tyr His His Ala Gln Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Leu Lys Lys  Tyr Pro Lys Leu Glu  Ala Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys His  Tyr Asp Leu Ala Lys  Leu Met Ile 
    1010                 1015                 1020             


Gln Pro  Asp Ser Ser Leu Gly  Lys Ala Thr Thr Arg  Met Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Lys Glu Ile  Lys Leu Ala 
    1040                 1045                 1050             


Asp Asp  Thr Ile Phe Thr Arg  Pro Gln Ile Glu Val  Asn Thr Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Val Lys Asp Met  Gln Thr Ile 
    1070                 1075                 1080             


Arg Lys  Val Met Ser Tyr Pro  Gln Val Asn Ile Val  Met Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Trp Pro Lys 
    1100                 1105                 1110             


Gly Asp  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Ser  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Ile Ile Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Ile Ala  Lys Gly Lys Thr Gln  Lys Leu Lys 
    1145                 1150                 1155             


Thr Ile  Lys Glu Leu Val Gly  Ile Lys Ile Met Glu  Gln Asp Glu 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Ile Ala  Phe Leu Glu Lys Lys  Gly Tyr Gln 
    1175                 1180                 1185             


Asp Ile  Gln Thr Ser Ser Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Leu Leu Ala  Ser Ala Lys 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Asn  Lys Tyr Val 
    1220                 1225                 1230             


Lys Phe  Leu Tyr Leu Ala Ser  His Tyr Thr Lys Phe  Thr Gly Lys 
    1235                 1240                 1245             


Glu Glu  Asp Arg Glu Lys Lys  Arg Ser Tyr Val Glu  Ser His Leu 
    1250                 1255                 1260             


Tyr Tyr  Phe Asp Val Arg Leu  Ser Gln Val Phe Arg  Val Thr Asn 
    1265                 1270                 1275             


Val Glu  Phe 
    1280     


<210>  158
<211>  1345
<212>  PRT
<213>  Streptococcus intermedius

<400>  158

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Glu Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ser Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Arg His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Asn Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asn  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Leu Val Lys 
    1130                 1135                 1140             


Asp Leu  Val Gly Ile Thr Ile  Met Glu Arg Thr Ile  Phe Glu Lys 
    1145                 1150                 1155             


Asn Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Val Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Arg Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Met Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Lys Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Asn Ile Leu Ala  Glu Ser Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Glu Glu Leu  Tyr Ala Gln Asn Asn  Asn Lys Asp 
    1265                 1270                 1275             


Ile Thr  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Asn Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Arg Leu Gly Gly Asp  
    1340                 1345 


<210>  159
<211>  1353
<212>  PRT
<213>  Streptococcus massiliensis

<400>  159

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Met Glu Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Val Glu Arg Arg Leu 
    50                  55                  60                  


Asn Arg Thr Thr Ser Arg Arg Tyr Asp Arg Arg Arg Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln His Ile Phe Ala Glu Glu Met Asn Arg Ala Asp Glu Asn 
                85                  90                  95      


Phe Phe His Arg Leu Lys Glu Ser Phe Phe Val Glu Glu Asp Lys Thr 
            100                 105                 110         


Tyr Ser Lys Tyr Pro Ile Phe Gly Thr Leu Glu Glu Glu Lys Asn Tyr 
        115                 120                 125             


His Lys Asn Tyr Pro Thr Ile Tyr His Leu Arg Lys Thr Leu Ala Asp 
    130                 135                 140                 


Thr Pro Asp Lys Met Asp Ile Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asp Ile 
                165                 170                 175     


Glu Asn Ile Gly Ile Gln Asp Ser Phe Lys Ser Phe Ile Glu Glu Tyr 
            180                 185                 190         


Asn Thr Gln Phe Gly Thr Lys Leu Asp Ser Thr Thr Lys Val Glu Ala 
        195                 200                 205             


Ile Phe Thr Glu Asn Ser Ser Lys Ala Lys Arg Val Glu Thr Ile Leu 
    210                 215                 220                 


Gly Leu Phe Pro Asp Glu Thr Ala Ala Gly Asn Leu Asp Lys Phe Leu 
225                 230                 235                 240 


Lys Leu Met Leu Gly Asn Gln Ala Asp Phe Lys Lys Val Phe Asp Leu 
                245                 250                 255     


Glu Glu Lys Ile Thr Leu Gln Phe Ser Lys Asp Ser Tyr Glu Glu Asp 
            260                 265                 270         


Leu Glu Leu Leu Leu Ser Lys Ile Asp Glu Glu Tyr Ala Ala Leu Phe 
        275                 280                 285             


Asp Leu Ala Lys Lys Val Tyr Asp Ala Val Leu Leu Ser Asn Ile Leu 
    290                 295                 300                 


Thr Val Lys Glu Lys Asn Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
305                 310                 315                 320 


Lys Arg Tyr Glu Glu His Lys Asp Asp Leu Lys Ala Phe Lys Arg Phe 
                325                 330                 335     


Phe Arg Glu Arg Leu Pro Glu Lys Tyr Glu Thr Met Phe Lys Asp Leu 
            340                 345                 350         


Thr Lys Pro Ser Tyr Ala Ala Tyr Val Ser Gly Leu Tyr Lys Lys Asp 
        355                 360                 365             


Ala Lys Arg Gly Leu Val Pro Thr Ser Lys Arg Val Thr Glu Asp Asp 
    370                 375                 380                 


Phe Tyr Lys Phe Ser Lys Gly Leu Leu Ile Asp Val Glu Gly Ala Glu 
385                 390                 395                 400 


Tyr Phe Leu Glu Lys Ile Glu Arg Glu Asp Phe Leu Arg Lys Gln Arg 
                405                 410                 415     


Thr Phe Asp Asn Gly Ala Ile Pro Asn Gln Val His Val Lys Glu Leu 
            420                 425                 430         


Gln Ala Ile Ile Leu Asn Gln Ser Lys Tyr Tyr Pro Phe Leu Ala Glu 
        435                 440                 445             


Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr 
    450                 455                 460                 


Val Gly Pro Leu Ala Arg Gly Asn Ser Ser Phe Ala Trp Leu Gln Arg 
465                 470                 475                 480 


Lys Ser Asp Glu Ala Ile Arg Pro Trp Asn Phe Glu Gln Val Val Asp 
                485                 490                 495     


Met Glu Thr Ser Ala Ser Arg Phe Ile Glu Arg Met Thr Leu His Asp 
            500                 505                 510         


Leu Tyr Leu Pro Asp Glu Lys Val Leu Pro Arg His Ser Leu Ile Tyr 
        515                 520                 525             


Glu Lys Tyr Thr Val Phe Asn Glu Leu Thr Lys Val Arg Phe Thr Pro 
    530                 535                 540                 


Glu Gly Gly Lys Glu Val Tyr Phe Ser Lys Thr Asp Lys Glu Asn Ile 
545                 550                 555                 560 


Phe Asp Ser Leu Phe Lys Arg Tyr Arg Lys Val Thr Lys Arg Lys Leu 
                565                 570                 575     


Lys Asp Phe Ile Glu Lys Glu Leu Gly Tyr Gly Tyr Ile Asp Ile Asp 
            580                 585                 590         


Asn Ile Lys Gly Val Glu Glu Gln Phe Asn Ala Ser Tyr Thr Thr Tyr 
        595                 600                 605             


Gln Asp Leu Leu Lys Ile Ile Gly Asp Lys Glu Phe Leu Asp Asn Glu 
    610                 615                 620                 


Glu Asn Lys Asp Leu Leu Glu Glu Ile Ile Tyr Ile Leu Thr Val Phe 
625                 630                 635                 640 


Glu Asp Arg Lys Met Ile Glu Lys Arg Leu Ser Glu Leu Asn Ile Pro 
                645                 650                 655     


Phe Glu Asn Lys Ile Ile Lys Lys Leu Ala Arg Lys Lys Tyr Thr Gly 
            660                 665                 670         


Trp Gly Asn Leu Ser Arg Lys Leu Ile Asp Gly Ile Arg Asn Arg Glu 
        675                 680                 685             


Thr Asn Arg Thr Ile Leu Gly His Leu Ile Asp Asp Gly Phe Ser Asn 
    690                 695                 700                 


Arg Asn Leu Met Gln Leu Ile Asn Asp Asp Gly Leu Asp Phe Lys Glu 
705                 710                 715                 720 


Ile Ile Arg Lys Ala Gln Thr Ile Glu Asn Ile Asp Thr Asn Gln Ala 
                725                 730                 735     


Leu Val Ser Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu 
            740                 745                 750         


Gln Ser Leu Asn Ile Val Asp Glu Ile Ile Ala Ile Met Gly Tyr Ala 
        755                 760                 765             


Pro Thr Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln 
    770                 775                 780                 


Lys Gly Arg Asp Asn Ser Ala Gln Arg Leu Lys Lys Ile Glu Asp Gly 
785                 790                 795                 800 


Ile Lys Leu Leu Gly Ser Asp Leu Leu Lys Gln Asn Pro Ile Gln Asp 
                805                 810                 815     


Asn Lys Asp Leu Gln Lys Glu Lys Leu Phe Leu Tyr Tyr Met Gln Asn 
            820                 825                 830         


Gly Ile Asp Leu Tyr Thr Gly Gln Pro Leu Asn Cys Asp Pro Asp Ser 
        835                 840                 845             


Leu Ala Phe Tyr Asp Val Asp His Ile Val Pro Arg Ser Tyr Ile Lys 
    850                 855                 860                 


Asn Asp Ser Phe Asp Asn Lys Val Leu Thr Thr Ser Lys Gly Asn Arg 
865                 870                 875                 880 


Lys Lys Leu Asp Asp Val Pro Ala Lys Glu Val Val Glu Lys Met Glu 
                885                 890                 895     


Asn Thr Trp Arg Arg Leu His Ala Ala Gly Leu Ile Ser Asp Ile Lys 
            900                 905                 910         


Leu Ser Tyr Leu Met Lys Gly Glu Leu Thr Glu Glu Asp Lys Ala Gly 
        915                 920                 925             


Phe Ile Arg Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
    930                 935                 940                 


Ala Arg Leu Leu Asp Glu Lys Leu Asn Arg Lys Lys Asn Glu Asn Gly 
945                 950                 955                 960 


Glu Lys Leu Arg Thr Thr Lys Ile Ile Thr Leu Lys Ser Val Phe Ala 
                965                 970                 975     


Ser Arg Phe Arg Ala Asn Phe Asp Leu Tyr Lys Leu Arg Glu Leu Asn 
            980                 985                 990         


His Tyr His His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Ala Gln 
        995                 1000                 1005             


Ala Leu  Leu Lys Val Tyr Pro  Lys Phe Glu Arg Glu  Leu Val Tyr 
    1010                 1015                 1020             


Gly Ser  Tyr Val Lys Glu Ser  Ile Phe Ser Arg Lys  Ile Ser Ala 
    1025                 1030                 1035             


Thr Glu  Arg Met Arg Met Tyr  Asn Asn Ile Leu Lys  Phe Ile Ser 
    1040                 1045                 1050             


Lys Asp  Lys Lys Val Asp Gln  Glu Thr Gly Glu Ile  Val Trp Asp 
    1055                 1060                 1065             


Lys Lys  Glu Ile Glu Asn Ile  Val Lys Lys Val Ile  Tyr Ser Ser 
    1070                 1075                 1080             


Pro Val  Asn Ile Val Lys Lys  Arg Glu Glu Gln Ser  Gly Ala Leu 
    1085                 1090                 1095             


Phe Lys  Gln Ser Asn Met Ala  Val Gly Tyr Asn Asn  Lys Leu Ile 
    1100                 1105                 1110             


Pro Arg  Lys Lys Asp Trp Ser  Val Asp Lys Tyr Gly  Gly Phe Ile 
    1115                 1120                 1125             


Glu Pro  Ala Glu Ser Tyr Ser  Leu Ala Ile Phe Tyr  Thr Asp Ile 
    1130                 1135                 1140             


Asn Gly  Lys Lys Pro Lys Lys  Lys Ser Thr Ile Ile  Ala Ile Ser 
    1145                 1150                 1155             


Arg Met  Glu Lys Lys Asp Tyr  Glu Lys Glu Pro Glu  Arg Phe Leu 
    1160                 1165                 1170             


Ala Gln  Lys Gly Phe Glu Arg  Val Glu Lys Thr Ile  Lys Leu Pro 
    1175                 1180                 1185             


Lys Tyr  Ser Leu Phe Glu Met  Glu Lys Gly Arg Arg  Arg Leu Leu 
    1190                 1195                 1200             


Ala Ser  Ser Gly Glu Leu Gln  Lys Gly Asn Gln Val  Leu Leu Pro 
    1205                 1210                 1215             


Glu His  Leu Ile Arg Leu Leu  Ser Tyr Ala Lys Lys  Val Asp Val 
    1220                 1225                 1230             


Leu Val  Lys Ser Lys Asp Asp  Asp Tyr Asp Leu Glu  Glu His Arg 
    1235                 1240                 1245             


Ala Glu  Phe Ala Glu Leu Leu  Asp Cys Ile Lys Lys  Phe Asn Asp 
    1250                 1255                 1260             


Met Tyr  Ile Leu Ala Ser Ser  Asn Met Ser Lys Ile  Glu Glu Ile 
    1265                 1270                 1275             


Tyr Gln  Lys Asn Ile Asp Ala  Pro Ile Glu Glu Val  Ala Arg Ser 
    1280                 1285                 1290             


Phe Val  Ala Leu Leu Asn Phe  Thr Met Met Gly Ala  Ala Thr Asp 
    1295                 1300                 1305             


Phe Lys  Phe Phe Gly Gln Ile  Ile Pro Arg Lys Arg  Tyr Pro Ser 
    1310                 1315                 1320             


Thr Thr  Glu Cys Leu Lys Ser  Thr Leu Ile His Gln  Ser Val Thr 
    1325                 1330                 1335             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Lys Leu  Gly Glu Asn 
    1340                 1345                 1350             


<210>  160
<211>  1376
<212>  PRT
<213>  Streptococcus mitis

<400>  160

Met Asn Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Asp Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Thr Glu Glu Met Ser Lys Val Asp Ile 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Glu Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Asn Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Ala Asp Phe Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Ile Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Asn Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Val Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Asp Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Ala Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Thr Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Leu 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Ile Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Gln Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Arg Ser Ala Glu Asp Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Gln Gln Ile Val Thr Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Gln Tyr Leu His Asn Val Asp Ser Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asp Ser Lys Asn Glu Ala Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala His Tyr Ala 
625                 630                 635                 640 


Ser Ile Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Tyr Asp 
            660                 665                 670         


Lys Gln Ser Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Glu 
        675                 680                 685             


Ile Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asn Asp Val 
705                 710                 715                 720 


Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Leu Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ala Leu Lys Asn Leu Ala His Gly Leu Asp Ser Asn Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Lys Ser Leu Asp 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Cys Asp Ile Asp His Ile Ile Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Ile Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 
            900                 905                 910         


Glu Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Thr 
    930                 935                 940                 


Glu Val Thr Glu Lys Asp Lys Lys Asp Arg Ser Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Arg Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Pro Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Arg Thr Lys Asp  Pro Lys Glu Val Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Thr Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Ala Thr Ile Lys Lys  Val Leu Ser Leu Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Thr Glu Glu  Gln Thr Val Gly Gln  Asn Gly Gly 
    1100                 1105                 1110             


Leu Phe  Asp Asn Asn Ile Val  Ser Lys Lys Lys Val  Val Asp Ala 
    1115                 1120                 1125             


Ser Lys  Leu Thr Pro Ile Lys  Ser Gly Leu Ser Pro  Glu Lys Tyr 
    1130                 1135                 1140             


Gly Gly  Tyr Ala Arg Pro Thr  Ile Ala Tyr Ser Val  Leu Val Ile 
    1145                 1150                 1155             


Ala Asp  Ile Glu Lys Gly Lys  Ala Lys Lys Leu Lys  Arg Ile Lys 
    1160                 1165                 1170             


Glu Met  Val Gly Ile Thr Val  Gln Asp Lys Lys Lys  Phe Glu Ala 
    1175                 1180                 1185             


Asn Pro  Ile Ala Tyr Leu Glu  Glu Cys Gly Tyr Lys  Asn Ile Asn 
    1190                 1195                 1200             


Pro Asn  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Phe 
    1205                 1210                 1215             


Asn Asn  Gly Gln Arg Arg Leu  Leu Ala Ser Ser Ile  Glu Leu Gln 
    1220                 1225                 1230             


Lys Gly  Asn Glu Leu Ile Val  Pro Tyr His Phe Thr  Ala Leu Leu 
    1235                 1240                 1245             


Tyr His  Ala Gln Arg Ile Asn  Lys Ile Ser Glu Pro  Ile His Lys 
    1250                 1255                 1260             


Gln Tyr  Val Glu Thr His Gln  Ser Glu Phe Lys Glu  Leu Leu Thr 
    1265                 1270                 1275             


Ala Ile  Ile Ser Leu Ser Lys  Lys Tyr Ile Gln Lys  Pro Asn Val 
    1280                 1285                 1290             


Glu Ser  Leu Leu Gln Gln Ala  Phe Asp Gln Ser Asp  Lys Asp Ile 
    1295                 1300                 1305             


Tyr Gln  Leu Ser Glu Ser Phe  Ile Ser Leu Leu Lys  Leu Ile Ser 
    1310                 1315                 1320             


Phe Gly  Ala Pro Gly Thr Phe  Lys Phe Leu Gly Val  Glu Ile Ser 
    1325                 1330                 1335             


Gln Ser  Asn Val Arg Tyr Gln  Ser Val Ser Ser Cys  Phe Asn Ala 
    1340                 1345                 1350             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1355                 1360                 1365             


Asp Leu  Ser Lys Leu Gly Glu  Asp 
    1370                 1375     


<210>  161
<211>  1370
<212>  PRT
<213>  Streptococcus mitis

<400>  161

Met Lys Lys Gly Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Phe Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Arg Phe Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Ala Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Ser Lys Val Asp Ser Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Asp Ser Phe Leu Ile Pro Glu Asp Lys Arg 
            100                 105                 110         


Glu Ser Lys Tyr Pro Ile Phe Ala Thr Leu Thr Glu Glu Lys Glu Tyr 
        115                 120                 125             


His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala Asp 
    130                 135                 140                 


Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ala Phe Asp Ile 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln Val 
        195                 200                 205             


Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Asp Leu Glu Asp Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Thr Asp 
        275                 280                 285             


Leu Phe Val Ser Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Glu Arg Tyr Glu Asn His Gln Asn Asp Leu Ala Ala Leu Lys 
                325                 330                 335     


Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe Ser 
            340                 345                 350         


Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Thr 
        355                 360                 365             


Gln Glu Thr Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe Glu 
    370                 375                 380                 


Gly Thr Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala Trp 
    450                 455                 460                 


Leu Thr Arg Asn Ser Asp Glu Ala Ile Arg Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Ile Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly Gln 
    530                 535                 540                 


Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Glu Asn Arg Lys Val Thr 
545                 550                 555                 560 


Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp Asp 
        595                 600                 605             


Ala Lys Asn Glu Ala Ile Leu Glu Asn Ile Val His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp Ser 
625                 630                 635                 640 


Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Cys Asp Lys 
            660                 665                 670         


Gln Thr Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Lys Ile 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe Lys 
    690                 695                 700                 


Glu Ile Ile Gln Lys Ala Gln Val Ile Gly Lys Thr Asp Asp Val Lys 
705                 710                 715                 720 


Gln Val Val Gln Glu Leu Ser Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His 
            740                 745                 750         


Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu Asp 
    770                 775                 780                 


Ser Leu Lys Ile Leu Ala Ser Gly Leu Asp Ser Asn Ile Leu Lys Glu 
785                 790                 795                 800 


Asn Pro Thr Asp Asn Asn Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr 
                805                 810                 815     


Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp Ile 
            820                 825                 830         


Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe 
        835                 840                 845             


Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys Asp 
    850                 855                 860                 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Glu Val Val Gln Lys 
865                 870                 875                 880 


Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser Glu 
                885                 890                 895     


Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp Glu 
            900                 905                 910         


Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Tyr Asn Thr Glu 
    930                 935                 940                 


Val Asn Glu Lys Asp Lys Lys Asn Arg Thr Val Lys Ile Ile Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Arg Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Ala Lys Ala Ile Leu  Lys Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Glu Tyr  Gln Lys Tyr Asp Leu  Lys Arg Tyr 
    1010                 1015                 1020             


Ile Ser  Arg Ser Lys Asp Pro  Lys Glu Val Glu Lys  Ala Thr Glu 
    1025                 1030                 1035             


Lys Tyr  Phe Phe Tyr Ser Asn  Leu Leu Asn Phe Phe  Lys Glu Glu 
    1040                 1045                 1050             


Val His  Tyr Ala Asp Gly Thr  Ile Val Lys Arg Glu  Asn Ile Glu 
    1055                 1060                 1065             


Tyr Ser  Lys Asp Thr Gly Glu  Ile Ala Trp Asn Lys  Glu Lys Asp 
    1070                 1075                 1080             


Phe Ala  Ile Ile Lys Lys Val  Leu Ser Leu Pro Gln  Val Asn Ile 
    1085                 1090                 1095             


Val Lys  Lys Arg Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1100                 1105                 1110             


Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu Ile Pro  Arg Lys Thr 
    1115                 1120                 1125             


Lys Asp  Ile Leu Leu Asp Thr  Thr Lys Tyr Gly Gly  Phe Asp Ser 
    1130                 1135                 1140             


Pro Val  Ile Ala Tyr Ser Ile  Leu Leu Ile Ala Asp  Ile Glu Lys 
    1145                 1150                 1155             


Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys Thr Leu  Val Gly Ile 
    1160                 1165                 1170             


Thr Ile  Met Glu Lys Ala Ala  Phe Glu Glu Asn Pro  Ile Thr Phe 
    1175                 1180                 1185             


Leu Glu  Asn Lys Gly Tyr His  Asn Val Arg Lys Glu  Asn Ile Leu 
    1190                 1195                 1200             


Cys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Arg 
    1205                 1210                 1215             


Arg Leu  Leu Ala Ser Ala Lys  Glu Leu Gln Lys Gly  Asn Glu Ile 
    1220                 1225                 1230             


Val Leu  Pro Val Tyr Leu Thr  Thr Leu Leu Tyr His  Ser Lys Asn 
    1235                 1240                 1245             


Val His  Lys Leu Asp Glu Pro  Gly His Leu Glu Tyr  Ile Gln Lys 
    1250                 1255                 1260             


His Arg  Asn Glu Phe Lys Asp  Leu Leu Asn Leu Val  Ser Glu Phe 
    1265                 1270                 1275             


Ser Gln  Lys Tyr Val Leu Ala  Asp Ala Asn Leu Glu  Lys Ile Lys 
    1280                 1285                 1290             


Ser Leu  Tyr Ala Asp Asn Glu  Gln Ala Asp Ile Glu  Ile Leu Ala 
    1295                 1300                 1305             


Asn Ser  Phe Ile Asn Leu Leu  Thr Phe Thr Ala Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Gly  Lys Asp Ile Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Thr  Val Ser Glu Ile Leu  Asn Ala Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Trp Ile Asp Leu Ser  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  162
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  162

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  163
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  163

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Ile Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  164
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  164

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser Tyr Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Arg Asn 
225                 230                 235                 240 


Leu Val Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Ala 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  165
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  165

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  166
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  166

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Gln Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  167
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  167

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  168
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  168

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  169
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  169

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  170
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  170

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Thr Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ser Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  171
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  171

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Arg Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  172
<211>  1355
<212>  PRT
<213>  Streptococcus mutans

<400>  172

Met Lys Lys Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Ala 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr His Ser Asp Glu Ala Val Met Pro Trp Asn Phe Asp Gln 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Gln Ala Phe Ile Glu His Met Thr 
                485                 490                 495     


Asn Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Thr Glu Ile Gly Glu Ala Lys Phe Phe Asp Ala Asn Leu Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Leu Phe Lys His Glu Arg Lys Val Thr Lys 
545                 550                 555                 560 


Lys Lys Leu Arg Thr Phe Leu Asp Lys Asn Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Ile Gln Gly Leu Asp Lys Glu Thr Glu Thr Phe Asn Ala Ser 
            580                 585                 590         


Tyr Ala Thr Tyr Gln Asp Leu Leu Lys Val Ile Lys Asp Lys Val Phe 
        595                 600                 605             


Met Asp Asn Pro Glu Asn Ala Glu Ile Leu Glu Asn Ile Val Leu Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Lys 
625                 630                 635                 640 


Tyr Ala Asp Val Phe Asp Lys Lys Val Ile Asp Gln Leu Ala Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Gln Ser Cys Lys Thr Ile Met Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Ala Gln Ser Asn Arg Asn Leu Met Gln Leu Ile Thr Asp Asp Asn Leu 
    690                 695                 700                 


Thr Phe Lys Asp Asp Ile Val Lys Ala Gln Tyr Val Asp Asn Ser Asp 
705                 710                 715                 720 


Asp Leu His Gln Val Val Gln Ser Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Lys Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Lys Gly Arg Arg Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Leu Lys Glu Ala Ile Lys Ser Leu Asp Arg Asp Leu Asn His Lys Ile 
785                 790                 795                 800 


Leu Lys Glu His Pro Thr Asp Asn Gln Ala Leu Gln Asn Asn Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ser 
            820                 825                 830         


Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Val Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Ser Lys Ala Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val 
865                 870                 875                 880 


Val Asn Arg Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Pro 
            900                 905                 910         


Asp Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu 
    930                 935                 940                 


Phe Asp Asp Asn Asn Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Val Lys Ala Leu Leu  Val Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu 
    1010                 1015                 1020             


Arg Lys  Thr Ala Thr Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met 
    1025                 1030                 1035             


Asn Met  Phe Lys Ser Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val 
    1040                 1045                 1050             


Glu Arg  Pro Met Ile Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala 
    1055                 1060                 1065             


Trp Asp  Lys Thr Lys His Ile  Thr Thr Val Lys Lys  Val Leu Ser 
    1070                 1075                 1080             


Tyr Pro  Gln Val Asn Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile 
    1085                 1090                 1095             


Gly Gln  Asn Gly Gly Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu 
    1100                 1105                 1110             


Glu Val  Ile Pro Ser Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn 
    1115                 1120                 1125             


Pro Glu  Lys Tyr Gly Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro 
    1130                 1135                 1140             


Ile Leu  Leu Ile Val Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val 
    1145                 1150                 1155             


Met Asp  Lys Lys Arg Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys 
    1160                 1165                 1170             


Asp Lys  Gly Tyr Gln Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu 
    1175                 1180                 1185             


Pro Lys  Tyr Thr Leu Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu 
    1190                 1195                 1200             


Trp Ala  Ser Ser Lys Glu Val  His Lys Gly Asn Gln  Leu Val Val 
    1205                 1210                 1215             


Ser Lys  Lys Ser Gln Asp Leu  Leu Tyr His Ala His  His Leu Asp 
    1220                 1225                 1230             


Asn Asp  Tyr Ser Asn Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe 
    1235                 1240                 1245             


Asp Ile  Leu Phe Asn Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys 
    1250                 1255                 1260             


Leu Gly  Lys Glu His Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys 
    1265                 1270                 1275             


Glu Arg  Asp Ser Ala Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile 
    1280                 1285                 1290             


Lys Leu  Leu Gly Phe Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser 
    1295                 1300                 1305             


Phe Leu  Gly Ile Lys Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys 
    1310                 1315                 1320             


Asp Tyr  Leu Leu Pro Cys Met  Glu Ala Thr Leu Ile  His Gln Ser 
    1325                 1330                 1335             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Asn  Lys Leu Gly 
    1340                 1345                 1350             


Gly Asp  
    1355 


<210>  173
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  173

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  174
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  174

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Phe Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ser Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Glu Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  175
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  175

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  176
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  176

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  177
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  177

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ser Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  178
<211>  1355
<212>  PRT
<213>  Streptococcus mutans

<400>  178

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Thr 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Gln Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr His Ser Asp Glu Ala Val Thr Pro Trp Asn Phe Asp Gln 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Gln Ala Phe Ile Glu His Met Thr 
                485                 490                 495     


Asn Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Thr Glu Ile Gly Glu Ala Lys Phe Phe Asp Ala Asn Leu Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Leu Phe Lys His Glu Arg Lys Val Thr Lys 
545                 550                 555                 560 


Lys Lys Leu Arg Thr Phe Leu Asp Lys Asn Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Ile Gln Gly Leu Asp Lys Glu Thr Glu Thr Phe Asn Ala Ser 
            580                 585                 590         


Tyr Ala Thr Tyr Gln Asp Leu Leu Lys Val Ile Lys Asp Lys Val Phe 
        595                 600                 605             


Met Asp Asn Pro Glu Asn Ala Glu Ile Leu Glu Asn Ile Val Leu Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Lys 
625                 630                 635                 640 


Tyr Ala Asp Val Phe Asp Lys Lys Val Ile Asp Gln Leu Ala Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Gln Ser Cys Lys Thr Ile Met Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Ala Gln Ser Asn Arg Asn Leu Met Gln Leu Ile Thr Asp Asp Asn Leu 
    690                 695                 700                 


Thr Phe Lys Asp Asp Ile Val Lys Ala Gln Tyr Val Asp Asn Ser Asp 
705                 710                 715                 720 


Asp Leu His Gln Val Val Gln Ser Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Lys Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Lys Gly Arg Arg Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Leu Lys Glu Ala Ile Lys Ser Leu Asp Arg Asp Leu Asn His Lys Ile 
785                 790                 795                 800 


Leu Lys Glu His Pro Thr Asp Asn Gln Ala Leu Gln Asn Asn Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ser 
            820                 825                 830         


Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Val Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Ser Lys Ala Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val 
865                 870                 875                 880 


Val Asn Arg Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu 
            900                 905                 910         


Asp Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu 
    930                 935                 940                 


Phe Asp Asp Asn Asn Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Val Lys Ala Leu Leu  Val Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu 
    1010                 1015                 1020             


Arg Lys  Thr Ala Thr Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met 
    1025                 1030                 1035             


Asn Met  Phe Lys Ser Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val 
    1040                 1045                 1050             


Glu Arg  Pro Met Ile Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala 
    1055                 1060                 1065             


Trp Asp  Lys Thr Lys His Ile  Thr Thr Val Lys Lys  Val Leu Ser 
    1070                 1075                 1080             


Tyr Pro  Gln Val Asn Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile 
    1085                 1090                 1095             


Gly Gln  Asn Gly Gly Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu 
    1100                 1105                 1110             


Glu Val  Ile Pro Ser Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn 
    1115                 1120                 1125             


Pro Glu  Lys Tyr Gly Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro 
    1130                 1135                 1140             


Ile Leu  Leu Ile Val Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val 
    1145                 1150                 1155             


Met Asp  Lys Lys Arg Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys 
    1160                 1165                 1170             


Asp Lys  Gly Tyr Gln Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu 
    1175                 1180                 1185             


Pro Lys  Tyr Thr Leu Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu 
    1190                 1195                 1200             


Trp Ala  Ser Ser Lys Glu Val  His Lys Gly Asn Gln  Leu Val Val 
    1205                 1210                 1215             


Ser Lys  Lys Ser Gln Asp Leu  Leu Tyr His Ala His  His Leu Asp 
    1220                 1225                 1230             


Asn Asp  Tyr Ser Asn Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe 
    1235                 1240                 1245             


Asp Ile  Leu Phe Asn Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys 
    1250                 1255                 1260             


Leu Gly  Lys Glu His Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys 
    1265                 1270                 1275             


Glu Arg  Asp Phe Ala Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile 
    1280                 1285                 1290             


Lys Leu  Leu Gly Phe Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser 
    1295                 1300                 1305             


Phe Leu  Gly Ile Lys Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys 
    1310                 1315                 1320             


Asp Tyr  Leu Leu Pro Cys Met  Glu Ala Thr Leu Ile  His Gln Ser 
    1325                 1330                 1335             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1340                 1345                 1350             


Gly Asp  
    1355 


<210>  179
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  179

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Ile  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  180
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  180

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  181
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  181

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Ser Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Thr His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  182
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  182

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Tyr Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  183
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  183

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Thr Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Cys Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Ser Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  184
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  184

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Leu Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Phe  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  185
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  185

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asn Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Ile Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  186
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  186

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Gly Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  187
<211>  1359
<212>  PRT
<213>  Streptococcus mutans

<400>  187

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Met Gln Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Arg Tyr Pro Ile Phe Gly Thr Leu Lys Glu Glu Lys Lys Tyr 
        115                 120                 125             


His Lys Glu Phe Lys Thr Ile Tyr His Leu Arg Glu Lys Leu Ala Asn 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ser Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asn Val Gln Ala Leu Phe Lys Asp Phe Val Glu Val Tyr 
            180                 185                 190         


Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Met Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Val Glu Cys Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Leu Leu Gly Glu Ile Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Ala Val Asp Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Lys Glu His Lys Glu Glu Leu Ala Ala Phe Lys 
                325                 330                 335     


Arg Phe Ile Lys Glu Lys Leu Pro Lys Lys Tyr Glu Glu Ile Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ala Asp Lys Lys 
        355                 360                 365             


Leu Arg Lys Arg Ser Gly Lys Leu Ala Thr Glu Glu Glu Phe Tyr Lys 
    370                 375                 380                 


Tyr Val Lys Gly Ile Leu Asn Lys Val Glu Gly Ala Asp Val Trp Leu 
385                 390                 395                 400 


Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Ser Ile Pro His Gln Ile His Leu Gln Glu Met His Ala Ile 
            420                 425                 430         


Leu Arg Arg Gln Gly Glu His Tyr Pro Phe Leu Lys Glu Asn Gln Asp 
        435                 440                 445             


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Val Arg Lys Gly Ser Arg Phe Ala Trp Ala Glu Tyr Lys Ala Asp 
465                 470                 475                 480 


Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp Ile Leu Asp Lys Glu Lys 
                485                 490                 495     


Ser Ala Glu Lys Phe Ile Thr Arg Met Thr Leu Asn Asp Leu Tyr Leu 
            500                 505                 510         


Pro Glu Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Thr Phe 
        515                 520                 525             


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Asn Glu Gln Gly 
    530                 535                 540                 


Glu Ala Lys Phe Phe Asp Ala Asn Met Lys Gln Glu Ile Phe Asp His 
545                 550                 555                 560 


Val Phe Lys Glu Asn Arg Lys Val Thr Lys Asp Lys Leu Leu Asn Tyr 
                565                 570                 575     


Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile Val Asn Leu Thr Gly Leu 
            580                 585                 590         


Asp Lys Glu Asn Lys Val Phe Asn Ser Ser Leu Gly Thr Tyr His Asp 
        595                 600                 605             


Leu Arg Lys Ile Leu Asn Lys Ser Phe Leu Asp Asn Lys Glu Asn Glu 
    610                 615                 620                 


Gln Ile Ile Glu Asp Ile Ile Gln Thr Leu Thr Leu Phe Glu Asp Arg 
625                 630                 635                 640 


Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr Ser Asp Ile Phe Thr Lys 
                645                 650                 655     


Ala Gln Leu Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg 
            660                 665                 670         


Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Asn Lys 
        675                 680                 685             


Thr Ile Leu Gly Tyr Leu Ile Asp Asp Gly Tyr Ser Asn Arg Asn Phe 
    690                 695                 700                 


Met Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala 
705                 710                 715                 720 


Lys Ala Gln Val Ile Gly Glu Met Asp Gly Leu Asn Gln Val Val Ser 
                725                 730                 735     


Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu 
            740                 745                 750         


Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His Asn Pro Ala Asn 
        755                 760                 765             


Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Ala Lys Gly Arg 
    770                 775                 780                 


Arg Ser Ser Gln Lys Arg Tyr Lys Arg Leu Glu Glu Ala Ile Lys Asn 
785                 790                 795                 800 


Leu Asp His Asp Leu Asn His Lys Ile Leu Lys Glu His Pro Thr Asp 
                805                 810                 815     


Asn Gln Ala Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu Gln Asn 
            820                 825                 830         


Gly Arg Asp Met Tyr Thr Glu Asp Pro Leu Asp Ile Asn Arg Leu Ser 
        835                 840                 845             


Asp Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn 
    850                 855                 860                 


Ser Ile Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys 
865                 870                 875                 880 


Ser Asp Asp Val Pro Ser Glu Glu Val Val His Lys Met Lys Pro Phe 
                885                 890                 895     


Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp 
            900                 905                 910         


Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp Lys Ala 
        915                 920                 925             


Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His 
    930                 935                 940                 


Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp Glu Asn 
945                 950                 955                 960 


Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser Asn Leu 
                965                 970                 975     


Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile 
            980                 985                 990         


Asn Asp Tyr His His Ala His Asp  Ala Tyr Leu Asn Ala  Val Ile Gly 
        995                 1000                 1005             


Lys Ala  Leu Leu Gly Val Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
    1010                 1015                 1020             


Tyr Gly  Asp Tyr Pro His Phe  His Gly His Lys Glu  Asn Lys Ala 
    1025                 1030                 1035             


Thr Ala  Lys Lys Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1040                 1045                 1050             


Lys Gly  Asp Val Arg Thr Asp  Lys Asn Gly Glu Ile  Ile Trp Lys 
    1055                 1060                 1065             


Lys Asp  Glu His Ile Ser Asn  Ile Lys Lys Val Leu  Ser Tyr Pro 
    1070                 1075                 1080             


Gln Val  Asn Ile Val Lys Lys  Val Glu Glu Gln Thr  Gly Gly Phe 
    1085                 1090                 1095             


Ser Lys  Glu Ser Ile Leu Pro  Lys Gly Asn Ser Asp  Lys Leu Ile 
    1100                 1105                 1110             


Pro Arg  Lys Thr Lys Lys Phe  Tyr Trp Asp Thr Lys  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser Ile Leu  Val Ile Ala 
    1130                 1135                 1140             


Asp Ile  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Thr  Val Lys Ala 
    1145                 1150                 1155             


Leu Val  Gly Val Thr Ile Met  Glu Lys Met Thr Phe  Glu Arg Asp 
    1160                 1165                 1170             


Pro Val  Ala Phe Leu Glu Arg  Lys Gly Tyr Arg Asn  Val Gln Glu 
    1175                 1180                 1185             


Glu Asn  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Lys Leu Glu 
    1190                 1195                 1200             


Asn Gly  Arg Lys Arg Leu Leu  Ala Ser Ala Arg Glu  Leu Gln Lys 
    1205                 1210                 1215             


Gly Asn  Glu Ile Val Leu Pro  Asn His Leu Glu Thr  Leu Leu Tyr 
    1220                 1225                 1230             


His Ala  Lys Asn Ile His Lys  Val Asp Glu Pro Lys  His Leu Asp 
    1235                 1240                 1245             


Tyr Val  Asp Lys His Lys Asp  Glu Phe Lys Glu Leu  Leu Asp Val 
    1250                 1255                 1260             


Val Ser  Asn Phe Ser Lys Lys  Tyr Thr Leu Ala Glu  Gly Asn Leu 
    1265                 1270                 1275             


Glu Lys  Ile Lys Glu Leu Tyr  Ala Gln Asn Asn Gly  Glu Asp Leu 
    1280                 1285                 1290             


Lys Glu  Leu Ala Ser Ser Phe  Ile Asn Leu Leu Thr  Phe Thr Ala 
    1295                 1300                 1305             


Ile Gly  Ala Pro Ala Ala Phe  Lys Phe Phe Asp Lys  Asn Ile Asp 
    1310                 1315                 1320             


Arg Lys  Arg Tyr Thr Ser Thr  Thr Glu Ile Leu Asn  Ala Thr Leu 
    1325                 1330                 1335             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1340                 1345                 1350             


Asn Lys  Leu Gly Gly Asp 
    1355                 


<210>  188
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  188

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Asp Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  189
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  189

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Lys Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Leu Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Ile Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  190
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  190

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Leu Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys His Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Phe  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  191
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  191

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Gln Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asp His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  192
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  192

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Lys His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  193
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  193

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Asp Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  194
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  194

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  195
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  195

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Ile Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Gln Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  196
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  196

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Lys Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Leu Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Ile Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  197
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  197

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Cys His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Asn Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ser Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  198
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  198

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Val Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  199
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  199

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Leu Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Asn Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Phe  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  200
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  200

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Ser Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  201
<211>  125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  n is a, c, g, or t

<400>  201
nnnnnnnngt ttttgtactc tcaagattta gaaataaatc ttgcagaagc tacaaagata       60

aggcttcatg ccgaaatcaa caccctgtca ttttatggca gggtgttttc gttatttaat      120

ttttt                                                                  125


<210>  202
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  n is a, c, g, or t

<400>  202
nnnnnnnnnn nnnnnnnngt ttttgtactc tcagaaatgc agaagctaca aagataaggc       60

ttcatgccga aatcaacacc ctgtcatttt atggcagggt gttttcgtta tttaattttt      120

t                                                                      121


<210>  203
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or t

<400>  203
nnnnnnnnnn nnnnnnnnnn gtttttgtac tctcagaaat gcagaagcta caaagataag       60

gcttcatgcc gaaatcaaca ccctgtcatt ttatggcagg gtgtttttt                  109


<210>  204
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or t

<400>  204
nnnnnnnnnn nnnnnnnnnn gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  205
<211>  88
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or t

<400>  205
nnnnnnnnnn nnnnnnnnnn gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt gttttttt                                          88


<210>  206
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or t

<400>  206
nnnnnnnnnn nnnnnnnnnn gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcatt tttttt                                                       76


<210>  207
<211>  1355
<212>  PRT
<213>  Streptococcus mutans

<400>  207

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Thr 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Gln Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr His Ser Asp Glu Ala Val Thr Pro Trp Asn Phe Asp Gln 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Gln Ala Phe Ile Glu His Met Thr 
                485                 490                 495     


Asn Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Thr Glu Ile Gly Glu Ala Lys Phe Phe Asp Ala Asn Leu Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Leu Phe Lys His Glu Arg Lys Val Thr Lys 
545                 550                 555                 560 


Lys Lys Leu Arg Thr Phe Leu Asp Lys Asn Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Ile Gln Gly Leu Asp Lys Glu Thr Glu Thr Phe Asn Ala Ser 
            580                 585                 590         


Tyr Ala Thr Tyr Gln Asp Leu Leu Lys Val Ile Lys Asp Lys Val Phe 
        595                 600                 605             


Met Asp Asn Pro Glu Asn Ala Glu Ile Leu Glu Asn Ile Val Leu Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Lys 
625                 630                 635                 640 


Tyr Ala Asp Val Phe Asp Lys Lys Val Ile Asp Gln Leu Ala Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Gln Ser Cys Lys Thr Ile Met Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Ala Gln Ser Asn Arg Asn Leu Met Gln Leu Ile Thr Asp Asp Asn Leu 
    690                 695                 700                 


Thr Phe Lys Asp Asp Ile Val Lys Ala Gln Tyr Val Asp Asn Ser Asp 
705                 710                 715                 720 


Asp Leu His Gln Val Val Gln Ser Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Lys Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Lys Gly Arg Arg Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Leu Lys Glu Ala Ile Lys Ser Leu Asp Arg Asp Leu Asn His Lys Ile 
785                 790                 795                 800 


Leu Lys Glu His Pro Thr Asp Asn Gln Ala Leu Gln Asn Asn Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ser 
            820                 825                 830         


Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Val Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Ser Lys Ala Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val 
865                 870                 875                 880 


Val Asn Arg Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu 
            900                 905                 910         


Asp Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu 
    930                 935                 940                 


Phe Asp Asp Asn Asn Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Val Lys Ala Leu Leu  Val Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Glu Tyr  Leu Lys Tyr Asn Ser  Tyr Arg Glu 
    1010                 1015                 1020             


Arg Lys  Thr Ala Thr Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met 
    1025                 1030                 1035             


Asn Met  Phe Lys Ser Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val 
    1040                 1045                 1050             


Glu Arg  Pro Met Ile Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala 
    1055                 1060                 1065             


Trp Asp  Lys Thr Lys His Ile  Thr Thr Val Lys Lys  Val Leu Ser 
    1070                 1075                 1080             


Tyr Pro  Gln Val Asn Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile 
    1085                 1090                 1095             


Gly Gln  Asn Gly Gly Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu 
    1100                 1105                 1110             


Glu Val  Ile Pro Ser Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn 
    1115                 1120                 1125             


Pro Glu  Lys Tyr Gly Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro 
    1130                 1135                 1140             


Ile Leu  Leu Ile Val Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val 
    1145                 1150                 1155             


Met Asp  Lys Lys Arg Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys 
    1160                 1165                 1170             


Asp Lys  Gly Tyr Gln Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu 
    1175                 1180                 1185             


Pro Lys  Tyr Thr Leu Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu 
    1190                 1195                 1200             


Trp Ala  Ser Ser Lys Glu Val  His Lys Gly Asn Gln  Leu Val Val 
    1205                 1210                 1215             


Ser Lys  Lys Ser Gln Asp Leu  Leu Tyr His Ala His  His Leu Asp 
    1220                 1225                 1230             


Asn Asp  Tyr Ser Asn Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe 
    1235                 1240                 1245             


Asp Ile  Leu Phe Asn Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys 
    1250                 1255                 1260             


Leu Gly  Lys Glu His Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys 
    1265                 1270                 1275             


Glu Arg  Asp Phe Ala Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile 
    1280                 1285                 1290             


Lys Leu  Leu Gly Phe Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser 
    1295                 1300                 1305             


Phe Leu  Gly Ile Lys Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys 
    1310                 1315                 1320             


Asp Tyr  Leu Leu Pro Cys Met  Glu Ala Thr Leu Ile  His Gln Ser 
    1325                 1330                 1335             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1340                 1345                 1350             


Gly Asp  
    1355 


<210>  208
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  208

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Val Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  209
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  209

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Thr Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Ser Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  210
<211>  1355
<212>  PRT
<213>  Streptococcus mutans

<400>  210

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Asn Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Ala 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr His Ser Asp Glu Ala Val Thr Pro Trp Asn Phe Asp Gln 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Gln Ala Phe Ile Glu His Met Thr 
                485                 490                 495     


Asn Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Thr Glu Ile Gly Glu Ala Lys Phe Phe Asp Ala Asn Leu Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Leu Phe Lys His Glu Arg Lys Val Thr Lys 
545                 550                 555                 560 


Lys Lys Leu Arg Thr Phe Leu Asp Lys Asn Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Ile Gln Gly Leu Asp Lys Glu Thr Glu Thr Phe Asn Ala Ser 
            580                 585                 590         


Tyr Ala Thr Tyr Gln Asp Leu Leu Lys Val Ile Lys Asp Lys Val Phe 
        595                 600                 605             


Met Asp Asn Pro Glu Asn Ala Glu Ile Leu Glu Asn Ile Val Leu Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Lys 
625                 630                 635                 640 


Tyr Ala Asp Val Phe Asp Lys Lys Val Ile Asp Gln Leu Ala Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Gln Ser Cys Lys Thr Ile Met Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Ala Gln Ser Asn Arg Asn Leu Met Gln Leu Ile Thr Asp Asp Asn Leu 
    690                 695                 700                 


Thr Phe Lys Asp Asp Ile Val Lys Ala Gln Tyr Val Asp Asn Ser Asp 
705                 710                 715                 720 


Asp Leu His Gln Val Val Gln Ser Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Lys Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Lys Gly Arg Arg Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Leu Lys Glu Ala Ile Lys Ser Leu Asp Arg Asp Leu Asn His Lys Ile 
785                 790                 795                 800 


Leu Lys Glu His Pro Thr Asp Asn Gln Ala Leu Gln Asn Asn Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ser 
            820                 825                 830         


Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Val Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Ser Lys Ala Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val 
865                 870                 875                 880 


Val Asn Arg Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu 
            900                 905                 910         


Asp Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu 
    930                 935                 940                 


Phe Asp Asp Asn Asn Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Val Lys Ala Leu Leu  Val Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu 
    1010                 1015                 1020             


Arg Lys  Thr Ala Thr Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met 
    1025                 1030                 1035             


Asn Met  Phe Lys Ser Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val 
    1040                 1045                 1050             


Glu Arg  Pro Met Ile Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala 
    1055                 1060                 1065             


Trp Asp  Lys Thr Lys His Ile  Thr Thr Val Lys Lys  Val Leu Ser 
    1070                 1075                 1080             


Tyr Pro  Gln Val Asn Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile 
    1085                 1090                 1095             


Gly Gln  Asn Gly Gly Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu 
    1100                 1105                 1110             


Glu Val  Ile Pro Ser Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn 
    1115                 1120                 1125             


Pro Glu  Lys Tyr Gly Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro 
    1130                 1135                 1140             


Ile Leu  Leu Ile Val Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val 
    1145                 1150                 1155             


Met Asp  Lys Lys Arg Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys 
    1160                 1165                 1170             


Asp Lys  Gly Tyr Gln Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu 
    1175                 1180                 1185             


Pro Lys  Tyr Thr Leu Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu 
    1190                 1195                 1200             


Trp Ala  Ser Ser Lys Glu Val  His Lys Gly Asn Gln  Leu Val Val 
    1205                 1210                 1215             


Ser Lys  Lys Ser Gln Asp Leu  Leu Tyr His Ala His  His Leu Asp 
    1220                 1225                 1230             


Asn Asp  Tyr Ser Asn Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe 
    1235                 1240                 1245             


Asp Ile  Leu Phe Asn Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys 
    1250                 1255                 1260             


Leu Gly  Lys Glu His Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys 
    1265                 1270                 1275             


Glu Arg  Asp Ser Ala Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile 
    1280                 1285                 1290             


Lys Leu  Leu Gly Phe Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser 
    1295                 1300                 1305             


Phe Leu  Gly Ile Lys Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys 
    1310                 1315                 1320             


Asp Tyr  Leu Leu Pro Cys Met  Glu Ala Thr Leu Ile  His Gln Ser 
    1325                 1330                 1335             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1340                 1345                 1350             


Gly Asp  
    1355 


<210>  211
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  211

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


Tyr Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  212
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  212

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Thr Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Ser Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Lys Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  213
<211>  1338
<212>  PRT
<213>  Streptococcus mutans

<400>  213

Met Asp Leu Ile Gly Thr Asn Ser Val Gly Trp Ala Val Val Thr Asp 
1               5                   10                  15      


Asp Tyr Lys Val Pro Ala Lys Lys Met Lys Val Leu Gly Asn Thr Asp 
            20                  25                  30          


Lys Ser His Ile Lys Lys Asn Leu Leu Gly Ala Leu Leu Phe Asp Ser 
        35                  40                  45              


Gly Asn Thr Ala Ala Asp Arg Arg Leu Lys Arg Thr Ala Arg Arg Arg 
    50                  55                  60                  


Tyr Thr Arg Arg Arg Asn Arg Ile Leu Tyr Leu Gln Glu Ile Phe Ala 
65                  70                  75                  80  


Glu Glu Met Ser Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Asp 
                85                  90                  95      


Ser Phe Leu Val Thr Glu Asp Lys Arg Gly Glu Arg His Pro Ile Phe 
            100                 105                 110         


Gly Asn Leu Glu Glu Glu Val Lys Tyr His Glu Asn Phe Pro Thr Ile 
        115                 120                 125             


Tyr His Leu Arg Gln Tyr Leu Ala Asp Asn Pro Glu Lys Val Asp Leu 
    130                 135                 140                 


Arg Leu Val Tyr Leu Ala Leu Ala His Ile Ile Lys Phe Arg Gly His 
145                 150                 155                 160 


Phe Leu Ile Glu Gly Lys Phe Asp Thr Arg Asn Asn Asp Val Gln Arg 
                165                 170                 175     


Leu Phe Gln Glu Phe Leu Ala Val Tyr Asp Asn Thr Phe Glu Asn Ser 
            180                 185                 190         


Ser Leu Gln Glu Gln Asn Val Gln Val Glu Glu Ile Leu Thr Asp Lys 
        195                 200                 205             


Ile Ser Lys Ser Ala Lys Lys Asp Arg Val Leu Lys Leu Phe Pro Asn 
    210                 215                 220                 


Glu Lys Ser Asn Gly Arg Phe Ala Glu Phe Leu Lys Leu Ile Val Gly 
225                 230                 235                 240 


Asn Gln Ala Asp Phe Lys Lys His Phe Glu Leu Glu Glu Lys Ala Pro 
                245                 250                 255     


Leu Gln Phe Ser Lys Asp Thr Tyr Glu Glu Glu Leu Glu Val Leu Leu 
            260                 265                 270         


Ala Gln Ile Gly Asp Asn Tyr Ala Glu Leu Phe Leu Ser Ala Lys Lys 
        275                 280                 285             


Leu Tyr Asp Ser Ile Leu Leu Ser Gly Ile Leu Thr Val Thr Asp Val 
    290                 295                 300                 


Ser Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Gln Arg Tyr Asn Glu 
305                 310                 315                 320 


His Gln Met Asp Leu Ala Gln Leu Lys Gln Phe Ile Arg Gln Lys Leu 
                325                 330                 335     


Ser Asp Lys Tyr Asn Glu Val Phe Ser Asp Val Ser Lys Asp Gly Tyr 
            340                 345                 350         


Ala Gly Tyr Ile Asp Gly Lys Thr Asn Gln Glu Ala Phe Tyr Lys Tyr 
        355                 360                 365             


Leu Lys Gly Leu Leu Asn Lys Ile Glu Gly Ser Gly Tyr Phe Leu Asp 
    370                 375                 380                 


Lys Ile Glu Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn 
385                 390                 395                 400 


Gly Ser Ile Pro His Gln Ile His Leu Gln Glu Met Arg Ala Ile Ile 
                405                 410                 415     


Arg Arg Gln Ala Glu Phe Tyr Pro Phe Leu Ala Asp Asn Gln Asp Arg 
            420                 425                 430         


Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
        435                 440                 445             


Ala Arg Gly Lys Ser Asp Phe Ala Trp Leu Ser Arg Lys Ser Ala Asp 
    450                 455                 460                 


Lys Ile Thr Pro Trp Asn Phe Asp Glu Ile Val Asp Lys Glu Ser Ser 
465                 470                 475                 480 


Ala Glu Ala Phe Ile Asn Arg Met Thr Asn Tyr Asp Leu Tyr Leu Pro 
                485                 490                 495     


Asn Gln Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Thr 
            500                 505                 510         


Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Lys Thr Glu Gln Gly Lys 
        515                 520                 525             


Thr Ala Phe Phe Asp Ala Asn Met Lys Gln Glu Ile Phe Asp Gly Val 
    530                 535                 540                 


Phe Lys Val Tyr Arg Lys Val Thr Lys Asp Lys Leu Met Asp Phe Leu 
545                 550                 555                 560 


Glu Lys Glu Phe Asp Glu Phe Arg Ile Val Asp Leu Thr Gly Leu Asp 
                565                 570                 575     


Lys Glu Asn Lys Ala Phe Asn Ala Ser Tyr Gly Thr Tyr His Asp Leu 
            580                 585                 590         


Arg Lys Ile Leu Asp Lys Asp Phe Leu Asp Asn Ser Lys Asn Glu Lys 
        595                 600                 605             


Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 
    610                 615                 620                 


Met Ile Arg Lys Arg Leu Glu Asn Tyr Ser Asp Leu Leu Thr Lys Glu 
625                 630                 635                 640 


Gln Val Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu 
                645                 650                 655     


Ser Ala Glu Leu Ile His Gly Ile Arg Asn Lys Glu Ser Arg Lys Thr 
            660                 665                 670         


Ile Leu Asp Tyr Leu Ile Asp Asp Gly Asn Ser Asn Arg Asn Phe Met 
        675                 680                 685             


Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala Lys 
    690                 695                 700                 


Ala Gln Val Ile Gly Glu Thr Asp Asn Leu Asn Gln Val Val Ser Asp 
705                 710                 715                 720 


Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys 
                725                 730                 735     


Ile Val Asp Glu Leu Val Lys Ile Met Gly His Gln Pro Glu Asn Ile 
            740                 745                 750         


Val Val Glu Met Ala Arg Glu Asn Gln Phe Thr Asn Gln Gly Arg Arg 
        755                 760                 765             


Asn Ser Gln Gln Arg Leu Lys Gly Leu Thr Asp Ser Ile Lys Glu Phe 
    770                 775                 780                 


Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu His Ser Gln Leu Gln 
785                 790                 795                 800 


Asn Asp Arg Leu Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr 
                805                 810                 815     


Thr Gly Glu Glu Leu Asp Ile Asp Tyr Leu Ser Gln Tyr Asp Ile Asp 
            820                 825                 830         


His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg 
        835                 840                 845             


Val Leu Thr Ser Ser Lys Glu Asn Arg Gly Lys Ser Asp Asp Val Pro 
    850                 855                 860                 


Ser Lys Asn Val Val Arg Lys Met Lys Ser Tyr Trp Ser Lys Leu Leu 
865                 870                 875                 880 


Ser Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
                885                 890                 895     


Glu Arg Gly Gly Leu Thr Asp Asp Asp Lys Ala Gly Phe Ile Lys Arg 
            900                 905                 910         


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu 
        915                 920                 925             


Asp Glu Arg Phe His Thr Glu Thr Asp Glu Asn Asn Lys Lys Ile Arg 
    930                 935                 940                 


Gln Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg 
945                 950                 955                 960 


Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His 
                965                 970                 975     


Ala His Asp Ala Tyr Leu Asn Ala Val Ile Gly Lys Ala Leu Leu Gly 
            980                 985                 990         


Val Tyr Pro Gln Leu Glu Pro Glu  Phe Val Tyr Gly Asp  Tyr Pro His 
        995                 1000                 1005             


Phe His  Gly His Lys Glu Asn  Lys Ala Thr Ala Lys  Lys Phe Phe 
    1010                 1015                 1020             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Lys Asp Asp  Val Arg Thr 
    1025                 1030                 1035             


Asp Lys  Asn Gly Glu Ile Ile  Trp Lys Lys Asp Glu  His Ile Ser 
    1040                 1045                 1050             


Asn Ile  Lys Lys Val Leu Ser  Tyr Pro Gln Val Asn  Ile Val Lys 
    1055                 1060                 1065             


Lys Val  Glu Glu Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1070                 1075                 1080             


Pro Lys  Gly Asn Ser Asp Lys  Leu Ile Pro Arg Lys  Thr Lys Lys 
    1085                 1090                 1095             


Phe Tyr  Trp Asp Thr Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Ile 
    1100                 1105                 1110             


Val Ala  Tyr Ser Ile Leu Val  Ile Ala Asp Ile Glu  Lys Gly Lys 
    1115                 1120                 1125             


Ser Lys  Lys Leu Lys Thr Val  Lys Ala Leu Val Gly  Val Thr Ile 
    1130                 1135                 1140             


Met Glu  Lys Met Thr Phe Glu  Arg Asp Pro Val Ala  Phe Leu Glu 
    1145                 1150                 1155             


Arg Lys  Gly Tyr Arg Asn Val  Gln Glu Glu Asn Ile  Ile Lys Leu 
    1160                 1165                 1170             


Pro Lys  Tyr Ser Leu Phe Lys  Leu Glu Asn Gly Arg  Lys Arg Leu 
    1175                 1180                 1185             


Leu Ala  Ser Ala Arg Glu Leu  Gln Lys Gly Asn Glu  Ile Val Leu 
    1190                 1195                 1200             


Pro Asn  His Leu Gly Thr Leu  Leu Tyr His Ala Lys  Asn Ile His 
    1205                 1210                 1215             


Lys Val  Asp Glu Pro Lys His  Leu Asp Tyr Val Asp  Lys His Lys 
    1220                 1225                 1230             


Asp Glu  Phe Lys Glu Leu Leu  Asp Val Val Ser Asn  Phe Ser Lys 
    1235                 1240                 1245             


Lys Tyr  Thr Leu Ala Glu Gly  Asn Leu Glu Lys Ile  Lys Glu Leu 
    1250                 1255                 1260             


Tyr Ala  Gln Asn Asn Gly Glu  Asp Leu Lys Glu Leu  Ala Ser Ser 
    1265                 1270                 1275             


Phe Ile  Asn Leu Leu Thr Phe  Thr Ala Ile Gly Ala  Pro Ala Thr 
    1280                 1285                 1290             


Phe Lys  Phe Phe Asp Lys Asn  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1295                 1300                 1305             


Thr Thr  Glu Ile Leu Asn Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Lys Leu  Gly Gly Asp 
    1325                 1330                 1335             


<210>  214
<211>  1373
<212>  PRT
<213>  Streptococcus oralis

<400>  214

Met Glu Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Arg Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Ala Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Ile Pro Glu Asp Lys 
            100                 105                 110         


Lys Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ile Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Asp Thr Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asn Asn Thr Phe Glu Gly Asn Ser Leu Ser Gly Gln Asn Val Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Arg Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Val Ala Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Thr Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Thr Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ser Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Glu Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Ser Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Arg 
    530                 535                 540                 


Gln Lys Lys Asp Ile Phe Tyr Thr Leu Phe Lys Ala Glu Asp Lys Arg 
545                 550                 555                 560 


Lys Val Thr Glu Lys Asp Ile Ile Gln Tyr Leu His Thr Val Asp Gly 
                565                 570                 575     


Tyr Asp Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser 
            580                 585                 590         


Leu Ser Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe 
        595                 600                 605             


Met Asp Asp Pro Asn Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr 
    610                 615                 620                 


Leu Thr Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln 
625                 630                 635                 640 


Tyr Asp Ser Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Lys Leu Ser Ser Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Gln Thr Gly Lys Thr Ile Leu Asp Tyr Leu Met Asp Asp 
        675                 680                 685             


Gly Tyr Asn Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Glu Leu 
    690                 695                 700                 


Ser Phe Lys Glu Ile Ile Lys Lys Ala Gln Val Val Gly Lys Thr Asp 
705                 710                 715                 720 


Asp Val Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Ile Lys Leu Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly His Glu Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Ile Glu Asp Ser Leu Lys Ile Leu Ala Ser Gly Leu Asn Ala Lys Ile 
785                 790                 795                 800 


Leu Lys Glu His Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Lys Pro 
            820                 825                 830         


Leu Asp Ile Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Leu Lys Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val 
865                 870                 875                 880 


Val Glu Lys Met Lys Thr Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu 
                885                 890                 895     


Ile Ser Tyr Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Asp Glu Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Tyr 
    930                 935                 940                 


Asn Thr Glu Val Asn Glu Lys Asp Lys Lys Asn Arg Thr Val Lys Ile 
945                 950                 955                 960 


Ile Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Arg 
                965                 970                 975     


Leu Tyr Lys Ile Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Lys Lys  Tyr Pro Lys 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Gln Lys  Tyr Asp Leu 
    1010                 1015                 1020             


Lys Arg  Tyr Ile Ser Arg Ser  Lys Asp Pro Lys Glu  Ile Glu Lys 
    1025                 1030                 1035             


Ala Thr  Glu Lys Tyr Phe Phe  Tyr Ser Asn Leu Leu  Asn Phe Phe 
    1040                 1045                 1050             


Lys Glu  Glu Val His Tyr Ala  Asp Gly Thr Ile Val  Lys Arg Glu 
    1055                 1060                 1065             


Asn Ile  Glu Tyr Ser Lys Asp  Thr Gly Glu Ile Ala  Trp Asn Lys 
    1070                 1075                 1080             


Glu Lys  Asp Phe Ala Thr Ile  Lys Lys Val Leu Ser  Leu Pro Gln 
    1085                 1090                 1095             


Val Asn  Ile Val Lys Lys Arg  Glu Val Gln Thr Gly  Gly Phe Ser 
    1100                 1105                 1110             


Lys Glu  Ser Ile Leu Pro Lys  Gly Asn Ser Asp Lys  Leu Ile Pro 
    1115                 1120                 1125             


Arg Lys  Thr Lys Asp Ile Leu  Trp Asp Thr Thr Lys  Tyr Gly Gly 
    1130                 1135                 1140             


Phe Asp  Ser Pro Val Ile Ala  Tyr Ser Ile Leu Leu  Ile Ala Asp 
    1145                 1150                 1155             


Ile Glu  Lys Gly Lys Ala Lys  Arg Leu Lys Thr Val  Lys Thr Leu 
    1160                 1165                 1170             


Val Gly  Ile Thr Ile Met Glu  Lys Ala Thr Phe Glu  Lys Ser Pro 
    1175                 1180                 1185             


Ile Ala  Phe Leu Glu Asn Lys  Gly Tyr His Asn Val  Arg Lys Glu 
    1190                 1195                 1200             


Asn Ile  Leu Cys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Lys Asn 
    1205                 1210                 1215             


Gly Arg  Arg Arg Met Leu Ala  Ser Ala Lys Glu Leu  Gln Lys Gly 
    1220                 1225                 1230             


Asn Glu  Ile Val Leu Pro Val  His Leu Thr Thr Leu  Leu Tyr His 
    1235                 1240                 1245             


Ala Lys  Asn Ile His Arg Leu  Asp Glu Pro Glu His  Leu Glu Tyr 
    1250                 1255                 1260             


Ile Gln  Lys His Arg Asn Glu  Phe Lys Gly Leu Leu  Asn Leu Val 
    1265                 1270                 1275             


Ser Glu  Phe Ser Gln Lys Tyr  Val Leu Ala Asp Ala  Asn Leu Glu 
    1280                 1285                 1290             


Lys Ile  Lys Asn Leu Tyr Ala  Asp Asn Glu Gln Ala  Asp Ile Glu 
    1295                 1300                 1305             


Ile Leu  Ala Asn Ser Phe Ile  Asn Leu Leu Thr Phe  Thr Ala Leu 
    1310                 1315                 1320             


Gly Ala  Pro Ala Ala Phe Lys  Phe Phe Gly Lys Asp  Val Asp Arg 
    1325                 1330                 1335             


Lys Arg  Tyr Thr Thr Val Ser  Glu Ile Leu Asn Ala  Thr Leu Ile 
    1340                 1345                 1350             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1355                 1360                 1365             


Lys Leu  Gly Glu Asp 
    1370             


<210>  215
<211>  1371
<212>  PRT
<213>  Streptococcus oralis

<400>  215

Met Glu Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ser Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Arg Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Ala Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Ile Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ala Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Asp Thr Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Ser Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Gly Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Val Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Thr Asp Tyr Phe Leu Glu Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Asp Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Glu Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Thr Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Gln Phe Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asp Ser Lys Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp 
625                 630                 635                 640 


Ser Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Ile Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asp Gly Ile Cys Asp 
            660                 665                 670         


Lys Gln Thr Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Lys 
        675                 680                 685             


Asn Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Glu Ile Thr Gln Lys Ala Gln Val Val Gly Lys Thr Asp Asp Val 
705                 710                 715                 720 


Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Thr Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ala Leu Lys Asn Leu Ala Ser Gly Leu Asp Ser Asn Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asn Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Lys Pro Leu Asp 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Val Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Leu Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Glu Val Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 
            900                 905                 910         


Glu Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Lys 
    930                 935                 940                 


Glu Val Asn Glu Lys Asp Lys Lys Asn Arg Thr Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Arg Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Arg Ser Arg Asn  Pro Lys Glu Val Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Thr Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Ala Thr Ile Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Arg Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Pro Lys Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Asp Ile Leu Trp Glu  Thr Thr Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Val Ile Ala Tyr Ser  Ile Leu Leu Ile Ala  Asp Ile Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ala Lys Lys Leu  Lys Thr Val Lys Thr  Leu Val Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Lys Ala  Ala Phe Glu Glu Asn  Pro Ile Thr 
    1175                 1180                 1185             


Phe Leu  Glu Asn Lys Gly Tyr  His Asn Val Arg Lys  Glu Asn Ile 
    1190                 1195                 1200             


Leu Cys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Ile Val  Leu Pro Val Tyr Leu  Thr Thr Leu Leu Tyr  His Ser Lys 
    1235                 1240                 1245             


Asn Val  His Lys Leu Asp Glu  Pro Glu His Leu Glu  Tyr Ile Gln 
    1250                 1255                 1260             


Lys His  Arg Asn Glu Phe Lys  Asp Leu Leu Asn Leu  Val Ser Glu 
    1265                 1270                 1275             


Phe Ser  Gln Lys Tyr Val Leu  Ala Asp Ala Asn Leu  Glu Lys Ile 
    1280                 1285                 1290             


Gln Asn  Leu Tyr Ala Asp Asn  Glu Gln Ala Asp Ile  Glu Ile Leu 
    1295                 1300                 1305             


Ala Asn  Ser Phe Ile Asn Leu  Leu Thr Phe Thr Ala  Leu Gly Ala 
    1310                 1315                 1320             


Pro Ala  Ala Phe Lys Phe Phe  Gly Lys Asp Ile Asp  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Thr  Thr Val Ser Glu Ile  Leu Asn Ala Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1355                 1360                 1365             


Gly Glu  Asp 
    1370     


<210>  216
<211>  1366
<212>  PRT
<213>  Streptococcus parasanguinis

<400>  216

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asn Lys Glu Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ala Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Ala Glu Met Asn Lys Val Asp Glu Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Gly Thr Leu Glu Glu Glu Lys Glu Tyr 
        115                 120                 125             


His Lys Gln Phe Pro Thr Ile Tyr Tyr Leu Arg Lys Ile Leu Ala Asp 
    130                 135                 140                 


Ser Lys Glu Lys Val Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Asp Ser Phe Asp Ile 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Thr Ile Leu Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Glu Ser Ser Leu Ser Lys Gly Asn Ala Gln Val 
        195                 200                 205             


Glu Glu Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Ser Leu Leu Gly Gln Ile Gly Asp Val Tyr Ala Asp 
        275                 280                 285             


Leu Phe Val Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ala Gly 
    290                 295                 300                 


Ile Leu Ser Val Lys Asp Pro Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Glu Arg Tyr Asp Asn His Gln Asn Asp Leu Ser Ala Leu Lys 
                325                 330                 335     


Gln Phe Val Arg Arg Asn Leu Pro Glu Lys Tyr Ala Glu Val Phe Ser 
            340                 345                 350         


Asp Asp Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Thr 
        355                 360                 365             


Gln Glu Gly Phe Tyr Lys Tyr Ile Lys Asn Leu Ile Ser Lys Ile Glu 
    370                 375                 380                 


Gly Ala Glu Tyr Phe Leu Glu Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Asn Ala Ile Leu Arg His Gln Gly Glu Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Lys Asp Lys Ile Glu Gln Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Asn Ser Asp Glu Ala Ile Arg Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Met Val Asp Lys Ser Ser Ser Ala Glu Asp Phe Ile His Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Ile Ala Glu Gly Met Lys Asp Tyr Gln Phe Leu Asp Ser Gly Gln 
    530                 535                 540                 


Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Glu Lys Arg Lys Val Thr 
545                 550                 555                 560 


Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys His Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp Asp 
        595                 600                 605             


Pro Lys Asn Glu Glu Ile Phe Glu Asn Ile Val His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Val Met Ile Lys Gln Arg Leu Asn Gln Tyr Asp Ser 
625                 630                 635                 640 


Ile Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Lys Thr Ser Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Tyr Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe Lys 
    690                 695                 700                 


Glu Thr Ile Gln Lys Ala Gln Val Val Gly Glu Thr Asn Asp Val Lys 
705                 710                 715                 720 


Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His 
            740                 745                 750         


Ala Pro Glu Ser Val Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Asn Lys Gly Lys Ser Lys Ser Gln Gln Arg Leu Lys Thr Leu Ser Asp 
    770                 775                 780                 


Ala Ile Ser Glu Leu Gly Ser Asn Ile Leu Lys Glu His Pro Thr Asp 
785                 790                 795                 800 


Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu Gln Asn 
                805                 810                 815     


Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp Ile Asn Gln Leu Ser 
            820                 825                 830         


Asn Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp 
        835                 840                 845             


Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys Asp Asn Arg Gly Lys 
    850                 855                 860                 


Ser Asp Asn Val Pro Ser Leu Glu Ile Val Glu Lys Met Lys Gly Phe 
865                 870                 875                 880 


Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser Glu Arg Lys Phe Asn 
                885                 890                 895     


Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp Glu Arg Asp Lys Val 
            900                 905                 910         


Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His 
        915                 920                 925             


Val Ala Gln Ile Leu Asp Asp Arg Phe Asn Ala Glu Val Asn Glu Lys 
    930                 935                 940                 


Asn Gln Lys Leu Arg Ser Val Lys Ile Ile Thr Leu Lys Ser Asn Leu 
945                 950                 955                 960 


Val Ser Asn Phe Arg Lys Glu Phe Gly Leu Tyr Lys Val Arg Glu Ile 
                965                 970                 975     


Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Ala 
            980                 985                 990         


Lys Ala Ile Leu Lys Lys Tyr Pro  Lys Leu Glu Pro Glu  Phe Val Tyr 
        995                 1000                 1005             


Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg Tyr Ile  Ser Arg Thr 
    1010                 1015                 1020             


Lys Asp  Pro Lys Glu Ile Glu  Lys Ala Thr Glu Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Asp Lys Val  Tyr Tyr Ala 
    1040                 1045                 1050             


Asp Gly  Thr Ile Ile Gln Arg  Gly Asn Val Glu Tyr  Ser Lys Asp 
    1055                 1060                 1065             


Thr Gly  Glu Ile Ala Trp Asn  Lys Lys Arg Asp Phe  Ala Ile Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Tyr Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Glu  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys Thr Lys  Asn Val Gln 
    1115                 1120                 1125             


Leu Asp  Thr Thr Lys Tyr Gly  Gly Phe Asp Ser Pro  Val Ile Ala 
    1130                 1135                 1140             


Tyr Ser  Ile Leu Leu Val Ala  Asp Val Glu Lys Gly  Lys Ser Lys 
    1145                 1150                 1155             


Lys Leu  Lys Thr Val Lys Ser  Leu Ile Gly Ile Thr  Ile Met Glu 
    1160                 1165                 1170             


Lys Val  Lys Phe Glu Ala Asn  Pro Val Ala Phe Leu  Glu Gly Lys 
    1175                 1180                 1185             


Gly Tyr  Gln Asn Val Val Glu  Glu Asn Ile Ile Arg  Leu Pro Lys 
    1190                 1195                 1200             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Arg Arg  Met Leu Ala 
    1205                 1210                 1215             


Ser Ala  Lys Glu Leu Gln Lys  Gly Asn Glu Met Val  Leu Pro Ser 
    1220                 1225                 1230             


Tyr Leu  Ile Ala Leu Leu Tyr  His Ala Lys Arg Ile  Gln Lys Lys 
    1235                 1240                 1245             


Asp Glu  Pro Glu His Leu Glu  Tyr Ile Lys Gln His  His Ser Glu 
    1250                 1255                 1260             


Phe Asn  Asp Leu Leu Asn Phe  Val Ser Glu Phe Ser  Gln Lys Tyr 
    1265                 1270                 1275             


Val Leu  Ala Glu Ser Asn Leu  Glu Lys Ile Lys Asn  Leu Tyr Ile 
    1280                 1285                 1290             


Asp Asn  Glu Gln Thr Asn Met  Glu Glu Ile Ala Asn  Ser Phe Ile 
    1295                 1300                 1305             


Asn Leu  Leu Thr Phe Thr Ala  Phe Gly Ala Pro Ala  Val Phe Lys 
    1310                 1315                 1320             


Phe Phe  Gly Lys Asp Ile Glu  Arg Lys Arg Tyr Ser  Thr Val Thr 
    1325                 1330                 1335             


Glu Ile  Leu Lys Ala Thr Leu  Ile His Gln Ser Leu  Thr Gly Leu 
    1340                 1345                 1350             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu Gly Glu  Glu 
    1355                 1360                 1365     


<210>  217
<211>  1337
<212>  PRT
<213>  Streptococcus parauberis

<400>  217

Met Lys Val Leu Gly Asn Thr Asp Arg Gln Thr Val Lys Lys Asn Met 
1               5                   10                  15      


Ile Gly Thr Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Arg Arg 
            20                  25                  30          


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Ile Asn Arg Ile 
        35                  40                  45              


Lys Tyr Leu Gln Ser Ile Phe Asp Asp Glu Met Ser Lys Ile Asp Ser 
    50                  55                  60                  


Ala Phe Phe Gln Arg Ile Lys Asp Ser Phe Leu Val Pro Asp Asp Lys 
65                  70                  75                  80  


Asn Asp Asp Arg His Pro Ile Phe Gly Asn Ile Lys Asp Glu Val Asp 
                85                  90                  95      


Tyr His Lys Asn Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala 
            100                 105                 110         


Asp Ser Asp Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
        115                 120                 125             


His Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asp 
    130                 135                 140                 


Ser Gln Asn Thr Asp Val Asn Ala Leu Phe Leu Lys Leu Val Asp Thr 
145                 150                 155                 160 


Tyr Asn Leu Met Phe Glu Asp Asp Lys Ile Asp Thr Gln Thr Ile Asp 
                165                 170                 175     


Ala Thr Val Ile Leu Thr Glu Lys Met Ser Lys Ser Arg Arg Leu Glu 
            180                 185                 190         


Asn Leu Ile Ala Lys Ile Pro Asn Gln Lys Lys Asn Thr Leu Phe Gly 
        195                 200                 205             


Asn Leu Ile Ser Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ala Asn 
    210                 215                 220                 


Phe Glu Leu Ser Glu Asp Ala Lys Leu Gln Ile Ser Lys Glu Ser Phe 
225                 230                 235                 240 


Glu Glu Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala 
                245                 250                 255     


Asp Leu Phe Ile Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser 
            260                 265                 270         


Asp Ile Leu Thr Val Lys Gly Val Asn Thr Lys Ala Pro Leu Ser Ala 
        275                 280                 285             


Ser Met Val Gln Arg Phe Asn Glu His Gln Asp Asp Leu Lys Leu Leu 
    290                 295                 300                 


Lys Lys Leu Val Lys Val Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe 
305                 310                 315                 320 


Asp Ile Lys Asp Lys Asn Gly Tyr Ala Gly Tyr Ile Asn Gly Lys Thr 
                325                 330                 335     


Ser Gln Glu Asp Phe Tyr Lys Tyr Ile Lys Pro Ile Leu Ser Lys Leu 
            340                 345                 350         


Lys Gly Ala Glu Ser Leu Ile Ser Lys Leu Glu Arg Glu Asp Phe Leu 
        355                 360                 365             


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
    370                 375                 380                 


Leu Asn Glu Leu Lys Ser Ile Ile Arg Arg Gln Glu Lys Tyr Tyr Pro 
385                 390                 395                 400 


Phe Leu Lys Asp Lys Gln Val Arg Ile Glu Lys Ile Phe Thr Phe Arg 
                405                 410                 415     


Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly Asn Ser Ser Phe Ala 
            420                 425                 430         


Trp Val Lys Arg Arg Ser Asn Glu Ser Ile Thr Pro Trp Asn Phe Glu 
        435                 440                 445             


Glu Val Val Glu Gln Glu Ala Ser Ala Lys Val Phe Ile Glu Arg Met 
    450                 455                 460                 


Thr Asn Phe Asp Thr Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
465                 470                 475                 480 


Ser Leu Leu Tyr Glu Met Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
                485                 490                 495     


Lys Tyr Gln Ala Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Ser Glu 
            500                 505                 510         


Glu Lys Ile Glu Ile Val Ser Asn Leu Phe Lys Thr Glu Arg Lys Val 
        515                 520                 525             


Thr Val Lys Gln Leu Lys Glu Asn Tyr Phe Asn Lys Ile Arg Cys Leu 
    530                 535                 540                 


Asp Ser Ile Thr Ile Ser Gly Val Glu Asp Lys Phe Asn Ala Ser Leu 
545                 550                 555                 560 


Gly Thr Tyr His Asp Leu Leu Asn Ile Ile Lys Asn Gln Lys Ile Leu 
                565                 570                 575     


Asp Asp Glu Gln Asn Gln Asp Ser Leu Glu Asp Ile Val Leu Thr Leu 
            580                 585                 590         


Thr Leu Phe Glu Asp Glu Lys Met Ile Ala Lys Arg Leu Ser Lys Tyr 
        595                 600                 605             


Glu Ser Ile Phe Asp Pro Ser Ile Leu Lys Lys Leu Lys Lys Arg His 
    610                 615                 620                 


Tyr Thr Gly Trp Gly Arg Leu Ser Gln Lys Leu Ile Asn Gly Ile Arg 
625                 630                 635                 640 


Asp Lys Gln Thr Gly Lys Thr Ile Leu Asp Phe Leu Ile Glu Asp Gly 
                645                 650                 655     


Gln Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Pro Ser Leu Asp 
            660                 665                 670         


Phe Ala Ser Ile Ile Lys Glu Ala Gln Glu Lys Thr Ile Lys Ser Glu 
        675                 680                 685             


Lys Leu Glu Glu Thr Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys 
    690                 695                 700                 


Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Val Val Lys Val 
705                 710                 715                 720 


Met Gly Tyr Glu Pro Ser Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
                725                 730                 735     


Gln Ser Thr Gln Arg Gly Ile Asn Asn Ser Arg Glu Arg Leu Arg Lys 
            740                 745                 750         


Leu Glu Glu Val His Lys Asn Ile Gly Ser Lys Ile Leu Lys Glu His 
        755                 760                 765             


Glu Ile Ser Asn Ala Gln Leu Gln Ser Asp Arg Val Tyr Leu Tyr Leu 
    770                 775                 780                 


Leu Gln Asp Gly Lys Asp Met Tyr Thr Gly Lys Asp Leu Asp Phe Asp 
785                 790                 795                 800 


Arg Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe Ile 
                805                 810                 815     


Lys Asp Asn Ser Ile Asp Asn Ile Val Leu Thr Ser Gln Glu Ser Asn 
            820                 825                 830         


Arg Gly Lys Ser Asp Asn Val Pro Tyr Ile Ala Ile Val Asn Lys Met 
        835                 840                 845             


Lys Ser Tyr Trp Gln His Gln Leu Lys Ser Gly Ala Ile Ser Gln Arg 
    850                 855                 860                 


Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Tyr 
865                 870                 875                 880 


Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile 
                885                 890                 895     


Thr Lys His Val Ala Gln Ile Leu Asn Asn Arg Phe Asn Asn Asn Val 
            900                 905                 910         


Asp Asp Ser Ser Lys Asn Lys Arg Pro Val Lys Ile Ile Thr Leu Lys 
        915                 920                 925             


Ser Lys Met Val Ser Asp Phe Arg Lys Glu Phe Gly Phe Tyr Lys Ile 
    930                 935                 940                 


Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala 
945                 950                 955                 960 


Val Val Gly Thr Ala Leu Leu Lys Lys Tyr Pro Lys Leu Glu Ala Glu 
                965                 970                 975     


Phe Val Tyr Gly Asp Tyr Lys His Tyr Asp Leu Ala Ser Leu Val Val 
            980                 985                 990         


Lys Ser Asp Thr Ser Leu Gly Lys  Ala Thr Ala Lys Met  Phe Phe Tyr 
        995                 1000                 1005             


Ser Asn  Ile Met Asn Phe Phe  Lys Lys Glu Val Arg  Leu Ala Asp 
    1010                 1015                 1020             


Gly Thr  Val Ile Thr Arg Pro  Gln Ile Glu Thr Asn  Thr Glu Thr 
    1025                 1030                 1035             


Gly Glu  Ile Val Trp Asp Lys  Val Lys Asp Ile Lys  Thr Ile Arg 
    1040                 1045                 1050             


Lys Val  Leu Ser Ile Pro Gln  Ile Asn Val Val Lys  Lys Thr Glu 
    1055                 1060                 1065             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Ser Lys Arg 
    1070                 1075                 1080             


Asp Ser  Asp Lys Leu Ile Pro  Arg Lys Asn Asn Trp  Asp Pro Lys 
    1085                 1090                 1095             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Ile Ile Ala Tyr  Ser Val Leu 
    1100                 1105                 1110             


Val Val  Ala Lys Val Thr Lys  Gly Lys Ser Gln Lys  Thr Lys Ser 
    1115                 1120                 1125             


Val Lys  Glu Leu Val Gly Ile  Thr Ile Met Glu Gln  Asn Glu Phe 
    1130                 1135                 1140             


Glu Lys  Asp Arg Ile Thr Phe  Leu Glu Lys Lys Gly  Tyr Gln Asp 
    1145                 1150                 1155             


Ile Gln  Glu Ser Leu Ile Ile  Lys Leu Pro Lys Phe  Ser Leu Phe 
    1160                 1165                 1170             


Glu Leu  Glu Asn Gly Arg Lys  Arg Leu Leu Ala Ser  Ala Lys Glu 
    1175                 1180                 1185             


Leu Gln  Lys Gly Asn Glu Leu  Ser Leu Pro Asn Lys  Tyr Ile Gln 
    1190                 1195                 1200             


Phe Leu  Tyr Leu Ala Ser Arg  Tyr Thr Ser Phe Ser  Gly Lys Glu 
    1205                 1210                 1215             


Glu Asp  Arg Glu Lys His Arg  His Phe Val Glu Ser  His Leu His 
    1220                 1225                 1230             


Tyr Phe  Asp Glu Ile Lys Asp  Ile Ile Ala Asp Phe  Ser Arg Arg 
    1235                 1240                 1245             


Tyr Ile  Leu Ala Asp Ala Asn  Leu Glu Lys Ile Leu  Thr Leu Tyr 
    1250                 1255                 1260             


Asn Glu  Lys Asn Gln Phe Ser  Ile Glu Glu Gln Ala  Thr Asn Met 
    1265                 1270                 1275             


Leu Asn  Leu Phe Thr Phe Thr  Gly Leu Gly Ala Pro  Ala Thr Leu 
    1280                 1285                 1290             


Lys Phe  Phe Asn Val Asp Ile  Asp Arg Lys Arg Tyr  Thr Ser Ser 
    1295                 1300                 1305             


Thr Glu  Ile Leu Asn Ser Thr  Leu Ile Arg Gln Ser  Ile Thr Gly 
    1310                 1315                 1320             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Lys Ile Gly  Gly Asp 
    1325                 1330                 1335         


<210>  218
<211>  1368
<212>  PRT
<213>  Streptococcus phocae

<400>  218

Met Val Glu Lys Lys Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys 
            20                  25                  30          


Lys Met Lys Val Leu Gly Asn Thr Ser Arg Gln Ser Ile Lys Lys Asn 
        35                  40                  45              


Met Ile Gly Ala Leu Leu Phe Asp Glu Gly Gly Pro Ala Ala Ser Thr 
    50                  55                  60                  


Arg Val Lys Arg Thr Thr Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg 
65                  70                  75                  80  


Leu Cys Tyr Leu Arg Asp Ile Phe Glu Ser Glu Met His Thr Ile Asp 
                85                  90                  95      


Lys His Phe Phe Leu Arg Leu Glu Asp Ser Phe Leu His Lys Ser Asp 
            100                 105                 110         


Lys Arg Tyr Glu Ala His Pro Ile Phe Gly Thr Leu Gln Glu Glu Lys 
        115                 120                 125             


Ala Tyr His Asp Asn Tyr Pro Thr Ile Tyr His Leu Arg Lys Ala Leu 
    130                 135                 140                 


Ala Asp Asn Thr Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 
145                 150                 155                 160 


Ala His Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Ala Leu 
                165                 170                 175     


Ser Ala Asn Asn Thr Asp Val Gln Gln Leu Val His Ala Leu Val Asp 
            180                 185                 190         


Ala Tyr Asn Ile Met Phe Glu Glu Asp Gln Leu Asp Ile Glu Ala Ile 
        195                 200                 205             


Asp Val Lys Ala Ile Leu Thr Glu Lys Ile Ser Lys Thr Arg Arg Leu 
    210                 215                 220                 


Glu Asn Leu Ile Ser Asn Ile Pro Gly Gln Lys Lys Asn Gly Leu Phe 
225                 230                 235                 240 


Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser 
                245                 250                 255     


His Phe Asn Leu Pro Glu Asp Ala Lys Leu Gln Leu Ala Lys Asp Thr 
            260                 265                 270         


Tyr Asp Glu Glu Leu Asn Asn Leu Leu Thr Gln Ile Gly Asp Glu Tyr 
        275                 280                 285             


Ala Asp Leu Phe Leu Ser Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu 
    290                 295                 300                 


Ser Asp Ile Leu Thr Val Asn Gly Asp Gly Thr Gln Ala Pro Leu Ser 
305                 310                 315                 320 


Ala Ser Leu Ile Lys Arg Tyr Glu Glu His Arg Gln Asp Leu Ala Leu 
                325                 330                 335     


Leu Lys Gln Met Phe Lys Glu Gln Leu Pro Asp Leu Tyr Arg Asp Val 
            340                 345                 350         


Phe Thr Asp Glu Asn Lys Asp Gly Tyr Ala Gly Tyr Ile Ser Gly Lys 
        355                 360                 365             


Thr Ser Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Pro Ile Leu Glu Thr 
    370                 375                 380                 


Leu Asp Gly Ala Glu Asp Phe Leu Thr Lys Ile Asn Arg Glu Asp Phe 
385                 390                 395                 400 


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile 
                405                 410                 415     


His Leu Gly Glu Leu Gln Ala Ile Leu Glu Arg Gln Gln Ala Tyr Tyr 
            420                 425                 430         


Pro Phe Leu Lys Asp Asn Gln Glu Lys Ile Glu Lys Ile Leu Thr Phe 
        435                 440                 445             


Arg Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe 
    450                 455                 460                 


Ala Trp Leu Thr Arg Thr Ser Asp Gln Lys Ile Thr Pro Trp Asn Phe 
465                 470                 475                 480 


Asp Glu Met Val Asp Gln Glu Ala Ser Ala Gln Ala Phe Ile Glu Arg 
                485                 490                 495     


Met Thr Asn Phe Asp Glu Tyr Leu Pro Gln Glu Lys Val Leu Pro Lys 
            500                 505                 510         


His Ser Leu Thr Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys 
        515                 520                 525             


Val Lys Tyr Val Thr Glu Gly Met Thr Lys Pro Glu Phe Leu Ser Ala 
    530                 535                 540                 


Gly Gln Lys Glu Gln Ile Val Glu Leu Leu Phe Lys Lys Tyr Arg Lys 
545                 550                 555                 560 


Val Thr Val Lys Gln Leu Lys Glu Asp Phe Phe Ser Lys Ile Glu Cys 
                565                 570                 575     


Phe Asp Thr Val Asp Ile Ser Gly Val Glu Asp Lys Phe Asn Ala Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Ala Phe 
        595                 600                 605             


Leu Asp Asn Ser Glu Asn Glu Asn Ile Ile Glu Asp Ile Ile Leu Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Lys Glu Met Ile Ala Asn Arg Leu Ala Val 
625                 630                 635                 640 


Tyr Glu Asp Leu Phe Asp Gln Asn Val Leu Lys Gln Leu Lys Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Lys Gln Leu Ile Asn Gly Met 
            660                 665                 670         


Arg Asp Lys His Thr Gly Lys Thr Ile Leu Asp Phe Leu Lys Ala Asp 
        675                 680                 685             


Gly Phe Ile Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Asn Leu 
    690                 695                 700                 


Ser Phe Lys Glu Glu Ile Lys Lys Ala Gln Glu Gly Gly Leu Lys Asp 
705                 710                 715                 720 


Ser Ile Asn Asp Gln Ile Arg Asp Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Thr Ile Asn Ile Val Asp Glu Ile Val Lys Ile 
            740                 745                 750         


Met Gly Lys Ala Pro Gln His Ile Val Val Glu Met Ala Arg Asp Val 
        755                 760                 765             


Gln Lys Thr Asp Ile Gly Val Lys Gln Ser Arg Glu Arg Met Lys Arg 
    770                 775                 780                 


Val Gln Glu Val Leu Lys Lys Leu Gly Ser Gln Leu Leu Lys Glu His 
785                 790                 795                 800 


Pro Val Glu Asn Phe Gln Leu Gln Asn Glu Arg Leu Tyr Leu Tyr Tyr 
                805                 810                 815     


Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Glu Leu Ser Ile Ser 
            820                 825                 830         


Asn Leu Ser His Tyr Asp Ile Asp His Ile Ile Pro Arg Ser Phe Ile 
        835                 840                 845             


Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Glu His Asn 
    850                 855                 860                 


Arg Gly Lys Thr Asp Asn Val Pro Ser Ile Glu Val Val Lys Arg Met 
865                 870                 875                 880 


Lys Pro Tyr Trp Gln Lys Leu Leu Asp Thr Lys Val Ile Ser Gln Arg 
                885                 890                 895     


Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Gln Glu Ser 
            900                 905                 910         


Asp Lys Ala Asn Phe Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile 
        915                 920                 925             


Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Phe Asn Thr Glu Arg 
    930                 935                 940                 


Asp Glu Lys Asp Arg Pro Ile Arg Arg Val Lys Val Ile Thr Leu Lys 
945                 950                 955                 960 


Ser Lys Phe Val Ser Asp Phe Arg Gln Asp Phe Gly Phe Tyr Lys Leu 
                965                 970                 975     


Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala 
            980                 985                 990         


Val Val Gly Thr Ala Leu Leu Lys  Met Tyr Pro Lys Leu  Ala Ser Glu 
        995                 1000                 1005             


Phe Val  Tyr Gly Asp Tyr Gln  Lys Tyr Asp Leu Lys  Arg Met Val 
    1010                 1015                 1020             


Gly Lys  Ser Gly Lys Ala Ser  Gly His Ala Thr Ala  Lys Tyr Phe 
    1025                 1030                 1035             


Phe Tyr  Ser Asn Leu Met Asn  Phe Phe Lys Ser Glu  Val Lys Leu 
    1040                 1045                 1050             


Ala Asn  Gly Asn Ile Ile Lys  Arg Ser Pro Ile Glu  Val Asn Glu 
    1055                 1060                 1065             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Thr Lys Asp  Phe Gly Thr 
    1070                 1075                 1080             


Val Arg  Lys Val Leu Ser Ala  Pro Gln Val Asn Ile  Val Lys Lys 
    1085                 1090                 1095             


Thr Glu  Ile Gln Thr Gly Gly  Phe Ser Asn Glu Thr  Ile Leu Ser 
    1100                 1105                 1110             


Lys Gly  Lys Ser Ser Lys Leu  Ile Pro Arg Lys Asn  Lys Trp Arg 
    1115                 1120                 1125             


Asp Thr  Thr Lys Tyr Gly Gly  Phe Asn Thr Pro Thr  Val Ala Tyr 
    1130                 1135                 1140             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ala Lys Lys 
    1145                 1150                 1155             


Leu Lys  Pro Val Lys Glu Leu  Val Gly Ile Thr Ile  Met Glu Arg 
    1160                 1165                 1170             


Thr Lys  Phe Glu Ala Asn Pro  Ile Ala Phe Leu Glu  Ser Lys Gly 
    1175                 1180                 1185             


Tyr His  Asp Ile Gln Glu His  Leu Met Ile Thr Leu  Pro Lys Tyr 
    1190                 1195                 1200             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Arg Arg Leu  Leu Ala Ser 
    1205                 1210                 1215             


Ala Thr  Glu Leu Gln Lys Gly  Asn Glu Met Val Leu  Pro Gln His 
    1220                 1225                 1230             


Leu Val  Thr Phe Leu Tyr Arg  Val Ser Lys Arg Asp  Lys Gly Thr 
    1235                 1240                 1245             


Gln Ser  Glu Asn Met Glu Tyr  Ile Ser Asn His Lys  Glu Lys Phe 
    1250                 1255                 1260             


Ile Glu  Ile Phe His Tyr Ile  Ile Arg Tyr Ala Glu  Lys Asn Val 
    1265                 1270                 1275             


Ile Lys  Pro Lys Val Ile Glu  Arg Leu Asn Asp Thr  Phe Asn Gln 
    1280                 1285                 1290             


Lys Phe  Asn Asp Ser Asp Leu  Thr Glu Leu Ser Ile  Ser Phe Leu 
    1295                 1300                 1305             


Asn Leu  Phe Lys Phe Thr Ser  Phe Gly Ala Pro Glu  Lys Phe Thr 
    1310                 1315                 1320             


Phe Leu  Asn Ser Glu Ile Lys  Gln Asp Asp Val Arg  Tyr Arg Ser 
    1325                 1330                 1335             


Thr Lys  Glu Cys Leu Asn Ser  Thr Leu Ile His Gln  Ser Val Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Phe  Gly Gly Asp 
    1355                 1360                 1365             


<210>  219
<211>  1376
<212>  PRT
<213>  Streptococcus pseudopneumoniae

<400>  219

Met Ser Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Asp Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ser Glu Glu Ile Ser Lys Val Asp Asn 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Thr Glu Glu Lys Glu 
        115                 120                 125             


Tyr Tyr Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Thr Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Thr Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Gln Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Ala Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Glu Gly Tyr Ala Gly Tyr Ile Asp Ser Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Ile 
    370                 375                 380                 


Asp Gly Ala Asp Tyr Leu Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Ala Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Lys Ile Ile Asn Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Leu Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Arg Phe Met Asp 
        595                 600                 605             


Glu Pro Lys Asn Gln Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Ala 
625                 630                 635                 640 


Ser Ile Phe Asp Glu Lys Val Ile Lys Thr Leu Thr Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Cys Ile Arg Asp 
            660                 665                 670         


Arg Lys Thr Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Tyr 
        675                 680                 685             


Asn Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Glu Ile Ile Gln Glu Ser Gln Val Val Gly Lys Pro Asp Asp Val 
705                 710                 715                 720 


Lys Gln Ile Val Gln Glu Leu Pro Gly Ser Ser Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Leu Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Asp Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ser Leu Lys Ile Leu Ala Ser Gly Leu Asn Ser Asn Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Asn Pro Leu Asp 
            820                 825                 830         


Ile Asn His Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ala Phe Trp Gln Gln Leu Leu Glu Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asn 
            900                 905                 910         


Glu Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Phe Asn Thr 
    930                 935                 940                 


Lys Val Asn Glu Lys Asn Gln Lys Ile Arg Thr Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Arg Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Arg Ser Arg Asp  Pro Lys Glu Ile Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Thr Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Ile 
    1070                 1075                 1080             


Asp Phe  Ala Thr Ile Arg Lys  Ile Leu Ser Leu Ser  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Thr Glu Glu  Gln Thr Val Gly Gln  Asn Gly Gly 
    1100                 1105                 1110             


Leu Phe  Asp Asn Asn Ile Val  Ser Lys Lys Lys Val  Val Asp Ala 
    1115                 1120                 1125             


Ser Lys  Leu Ile Pro Ile Lys  Ser Gly Leu Ser Pro  Glu Lys Tyr 
    1130                 1135                 1140             


Gly Gly  Tyr Ala Arg Pro Thr  Ile Ala Tyr Ser Val  Leu Val Ile 
    1145                 1150                 1155             


Ala Asp  Ile Glu Lys Gly Lys  Ala Lys Lys Leu Lys  Arg Ile Lys 
    1160                 1165                 1170             


Glu Met  Val Gly Ile Thr Ile  Gln Asp Lys Lys Lys  Phe Glu Ala 
    1175                 1180                 1185             


Asn Pro  Thr Ala Tyr Leu Glu  Glu Tyr Gly Tyr Lys  Asn Ile Asn 
    1190                 1195                 1200             


Pro Asn  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Phe 
    1205                 1210                 1215             


Asn Asp  Gly Gln Arg Arg Leu  Leu Ala Ser Ser Ile  Glu Leu Gln 
    1220                 1225                 1230             


Lys Gly  Asn Glu Leu Ile Leu  Pro Tyr His Phe Thr  Thr Leu Leu 
    1235                 1240                 1245             


Tyr His  Ala Gln Arg Ile Asn  Lys Ile Ser Glu Pro  Ile His Lys 
    1250                 1255                 1260             


Gln Tyr  Val Glu Thr His Gln  Ser Glu Phe Glu Glu  Leu Leu Thr 
    1265                 1270                 1275             


Thr Ile  Ile Ser Leu Ser Lys  Lys Tyr Ile Gln Lys  Pro Ile Val 
    1280                 1285                 1290             


Glu Ser  Leu Leu Gln Gln Ala  Phe Glu Gln Ala Asp  Lys Asp Ile 
    1295                 1300                 1305             


Tyr Gln  Leu Ser Glu Ser Phe  Ile Ser Leu Leu Lys  Leu Thr Ser 
    1310                 1315                 1320             


Phe Gly  Ala Pro Gly Ala Phe  Arg Phe Leu Gly Val  Glu Ile Ser 
    1325                 1330                 1335             


Gln Ser  Asn Val Arg Tyr Gln  Ser Val Ser Ser Cys  Phe Asn Ala 
    1340                 1345                 1350             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1355                 1360                 1365             


Asp Leu  Ser Lys Leu Gly Glu  Asp 
    1370                 1375     


<210>  220
<211>  1376
<212>  PRT
<213>  Streptococcus pseudopneumoniae

<400>  220

Met Ser Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Val Ile Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Asp Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Asn Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ala Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Asn Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ala Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Asn Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Glu Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Ser Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Gly Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Gln Asn His Gln Asn Asp Leu Ala Ser Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Val Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Glu Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Gln Tyr Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asp Ser Lys Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp 
625                 630                 635                 640 


Ser Ile Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Thr Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Tyr 
        675                 680                 685             


Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Glu Ile Ile Gln Lys Ala Gln Val Phe Gly Lys Thr Asn Asp Val 
705                 710                 715                 720 


Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Glu Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Glu Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Thr Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asn Ser Leu Lys Ile Leu Ala Ser Gly Leu Asn Ser Lys Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Asn Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Cys Asp Ile Asp His Ile Ile Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Glu Asn Arg Gly Lys Ser Asp Asn Val Pro Cys Leu Glu Val Val Asp 
865                 870                 875                 880 


Lys Met Lys Val Phe Trp Gln Gln Leu Leu Asp Phe Lys Leu Ile Ser 
                885                 890                 895     


Tyr Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 
            900                 905                 910         


Glu Arg Asp Lys Val Gly Phe Ile Arg Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Phe Asn Thr 
    930                 935                 940                 


Glu Val Thr Glu Lys Asp Lys Lys Asn Arg Asn Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Arg Ser Lys Asp  Pro Lys Asp Ile Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Thr Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Ala Thr Ile Lys Lys  Ile Leu Ser Leu Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Thr Glu Glu  Gln Thr Val Gly Gln  Asn Gly Gly 
    1100                 1105                 1110             


Leu Phe  Asp Asn Asn Ile Val  Ser Lys Lys Lys Val  Val Asp Ala 
    1115                 1120                 1125             


Ser Lys  Leu Ile Pro Ile Lys  Ser Gly Leu Ser Pro  Glu Lys Tyr 
    1130                 1135                 1140             


Gly Gly  Tyr Ala Arg Pro Thr  Ile Ala Tyr Ser Val  Leu Val Ile 
    1145                 1150                 1155             


Ala Asp  Ile Glu Lys Gly Lys  Thr Lys Lys Leu Lys  Arg Ile Lys 
    1160                 1165                 1170             


Glu Met  Ile Gly Ile Thr Val  Gln Asp Lys Lys Ile  Phe Glu Ser 
    1175                 1180                 1185             


Asn Pro  Ile Ala Tyr Leu Glu  Glu Cys Gly Tyr Lys  Asn Ile Asn 
    1190                 1195                 1200             


Pro Asn  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Phe 
    1205                 1210                 1215             


Asn Gly  Gly Gln Arg Arg Leu  Leu Ala Ser Ser Ile  Glu Leu Gln 
    1220                 1225                 1230             


Lys Gly  Asn Glu Leu Ile Leu  Pro Tyr His Phe Thr  Ala Leu Leu 
    1235                 1240                 1245             


Tyr His  Thr Gln Arg Ile Asn  Lys Ile Ser Glu Pro  Ile His Lys 
    1250                 1255                 1260             


Gln Tyr  Val Glu Ala His Gln  Asn Glu Phe Lys Glu  Leu Leu Thr 
    1265                 1270                 1275             


Thr Ile  Ile Ser Leu Ser Lys  Lys Tyr Ile Gln Lys  Pro Asn Val 
    1280                 1285                 1290             


Glu Ser  Leu Leu Gln Gln Ala  Phe Glu Gln Ala Asp  Lys Asp Ile 
    1295                 1300                 1305             


Tyr Gln  Leu Ser Glu Ser Phe  Ile Ser Leu Leu Lys  Leu Thr Ser 
    1310                 1315                 1320             


Phe Gly  Ala Pro Gly Ala Phe  Lys Phe Leu Gly Val  Glu Ile Ser 
    1325                 1330                 1335             


Gln Ser  Ser Val Arg Tyr Lys  Pro Asn Ser Gln Phe  Leu Asp Ala 
    1340                 1345                 1350             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1355                 1360                 1365             


Asp Leu  Ser Lys Leu Gly Glu  Asp 
    1370                 1375     


<210>  221
<211>  1378
<212>  PRT
<213>  Streptococcus pseudopneumoniae

<400>  221

Met Ser Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Thr Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Asp Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ser Gly Glu Met Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Val Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Val Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ala Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Thr Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Gly Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Thr Thr Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Thr Asp Tyr Phe Leu Glu Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile His Tyr Leu His Thr Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asp Ser Lys Asn Glu Ala Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp 
625                 630                 635                 640 


Ser Leu Phe Asp Lys Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Cys Asp 
            660                 665                 670         


Lys Gln Thr Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Glu 
        675                 680                 685             


Ile Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Lys Ile Ile Gln Lys Ser Gln Val Val Gly Glu Thr Asp Asp Val 
705                 710                 715                 720 


Lys Gln Val Val Arg Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Asp 
            740                 745                 750         


His Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ser Leu Lys Ile Leu Ala Ser Gly Leu Asp Ser Asn Ile Leu Lys 
785                 790                 795                 800 


Glu Asn Pro Thr Asp Asn Asn Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Glu Arg Asp Gly 
            900                 905                 910         


Leu Asn Glu Leu Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Phe 
    930                 935                 940                 


Asn Lys Glu Val Thr Glu Lys Asp Lys Lys Asn Arg Asn Val Lys Ile 
945                 950                 955                 960 


Ile Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Arg 
                965                 970                 975     


Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Lys Lys  Tyr Pro Lys 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Gln Lys  Asn Asp Leu 
    1010                 1015                 1020             


Lys Arg  Tyr Ile Ser Arg Ser  Lys Asp Pro Lys Asp  Ile Glu Lys 
    1025                 1030                 1035             


Ala Thr  Glu Lys Tyr Phe Phe  Tyr Ser Asn Leu Leu  Asn Phe Phe 
    1040                 1045                 1050             


Lys Glu  Glu Val His Tyr Ala  Asp Gly Thr Ile Val  Lys Arg Glu 
    1055                 1060                 1065             


Asn Ile  Glu Tyr Ser Lys Asp  Thr Gly Glu Ile Ala  Trp Asn Lys 
    1070                 1075                 1080             


Glu Lys  Asp Phe Ala Thr Ile  Lys Lys Val Leu Ser  Tyr Pro Gln 
    1085                 1090                 1095             


Val Asn  Ile Val Lys Lys Thr  Glu Glu Gln Thr Val  Gly Gln Asn 
    1100                 1105                 1110             


Gly Gly  Leu Phe Asp Asn Asn  Ile Val Ser Lys Glu  Lys Val Val 
    1115                 1120                 1125             


Asp Ala  Ser Lys Leu Ile Pro  Ile Lys Ser Gly Leu  Ser Pro Glu 
    1130                 1135                 1140             


Lys Tyr  Gly Gly Tyr Ala Arg  Pro Thr Ile Ala Tyr  Ser Val Leu 
    1145                 1150                 1155             


Val Ile  Ala Asp Ile Glu Lys  Gly Lys Thr Lys Lys  Leu Lys Arg 
    1160                 1165                 1170             


Ile Lys  Glu Met Val Gly Ile  Thr Ile Gln Asp Lys  Lys Lys Phe 
    1175                 1180                 1185             


Glu Ala  Asn Pro Ile Ala Tyr  Leu Glu Glu Cys Gly  Tyr Lys Asn 
    1190                 1195                 1200             


Ile Asn  Pro Asn Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1205                 1210                 1215             


Glu Phe  Asn Gly Gly Gln Arg  Arg Leu Leu Ala Ser  Ser Ile Glu 
    1220                 1225                 1230             


Leu Gln  Lys Gly Asn Glu Leu  Ile Leu Pro Tyr His  Phe Thr Ala 
    1235                 1240                 1245             


Leu Leu  Tyr His Ala Gln Arg  Ile Asn Lys Phe Ser  Glu Pro Ile 
    1250                 1255                 1260             


His Lys  Gln Tyr Val Glu Ala  His Gln Asn Glu Phe  Lys Glu Leu 
    1265                 1270                 1275             


Leu Thr  Ile Ile Ile Ser Leu  Ser Lys Lys Tyr Ile  Gln Lys Pro 
    1280                 1285                 1290             


Asn Val  Glu Ser Leu Leu His  Gln Ala Phe Glu Gln  Ala Asp Asn 
    1295                 1300                 1305             


Asp Ile  Tyr Gln Leu Ser Glu  Ser Phe Ile Ser Leu  Leu Lys Leu 
    1310                 1315                 1320             


Thr Ser  Phe Gly Ala Pro Gly  Ala Phe Lys Phe Leu  Gly Ala Glu 
    1325                 1330                 1335             


Ile Ser  Gln Ser Ser Val Arg  Tyr Lys Pro Asn Ser  Gln Phe Leu 
    1340                 1345                 1350             


Asp Thr  Thr Leu Ile His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr 
    1355                 1360                 1365             


Arg Ile  Asp Leu Ser Lys Leu  Gly Glu Asp 
    1370                 1375             


<210>  222
<211>  1374
<212>  PRT
<213>  Streptococcus pseudoporcinus

<400>  222

Met Lys Lys Arg Tyr Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Ile Asn Glu Asp Tyr Lys Val Pro Ala Lys 
            20                  25                  30          


Lys Met Thr Val Phe Gly Asn Thr Asp Arg Lys Thr Ile Lys Lys Asn 
        35                  40                  45              


Leu Leu Gly Thr Val Leu Phe Asp Ser Gly Glu Thr Ala Gln Ala Arg 
    50                  55                  60                  


Arg Leu Lys Arg Thr Asn Arg Arg Arg Tyr Thr Arg Arg Arg Tyr Arg 
65                  70                  75                  80  


Leu Cys Gln Leu Gln Asn Ile Phe Ala Thr Glu Met Val Lys Val Asp 
                85                  90                  95      


Asp Thr Phe Phe Gln Arg Leu Ser Glu Ser Phe Phe Tyr Tyr Gln Asp 
            100                 105                 110         


Lys Ala Phe Asp Lys His Pro Ile Phe Gly Asn Ser Lys Glu Glu Arg 
        115                 120                 125             


Ala Tyr His Lys Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Asp Leu 
    130                 135                 140                 


Ala Asp Arg Asp Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 
145                 150                 155                 160 


Ser His Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Leu 
                165                 170                 175     


Asn Ser Glu Asn Thr Asp Val Gln Lys Leu Phe Ile Ala Leu Val Thr 
            180                 185                 190         


Val Tyr Asn Leu Leu Phe Glu Glu Glu Pro Ile Ala Gly Glu Thr Cys 
        195                 200                 205             


Asp Ala Lys Ala Leu Leu Thr Ala Lys Thr Ser Lys Ser Lys Arg Leu 
    210                 215                 220                 


Glu Ser Leu Ile Ser Glu Phe Pro Gly Gln Lys Lys Asn Gly Leu Phe 
225                 230                 235                 240 


Gly Asn Leu Leu Ala Leu Ala Leu Gly Leu Arg Pro Asn Phe Lys Ser 
                245                 250                 255     


Asn Phe Gly Leu Ser Glu Asp Ala Lys Leu Gln Ile Thr Lys Asp Thr 
            260                 265                 270         


Tyr Glu Glu Glu Leu Asp Asn Leu Leu Ala Glu Ile Gly Asp His Tyr 
        275                 280                 285             


Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu 
    290                 295                 300                 


Ser Asp Ile Leu Thr Leu Ser Asp Glu Asn Thr Arg Ala Pro Leu Ser 
305                 310                 315                 320 


Ala Ser Met Ile Lys Arg Tyr Glu Glu His Gln Glu Asp Leu Ala Leu 
                325                 330                 335     


Leu Lys Lys Leu Val Lys Glu Gln Met Pro Glu Lys Tyr Trp Glu Ile 
            340                 345                 350         


Phe Ser Asn Ala Lys Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Gly Lys 
        355                 360                 365             


Val Ser Gln Glu Asp Phe Tyr Arg Tyr Ile Lys Pro Ile Leu Ser Arg 
    370                 375                 380                 


Leu Lys Gly Gly Asp Glu Phe Leu Ala Lys Ile Asp Arg Asp Asp Phe 
385                 390                 395                 400 


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile 
                405                 410                 415     


His Leu Lys Glu Leu His Ala Ile Leu Arg Arg Gln Glu Lys Tyr Tyr 
            420                 425                 430         


Pro Phe Leu Ala Glu Gln Lys Glu Lys Ile Glu Gln Leu Leu Cys Phe 
        435                 440                 445             


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Gly Gly Asn Ser Ser 
    450                 455                 460                 


Phe Ala Trp Leu Lys Arg Arg Ser Asp Glu Pro Ile Thr Pro Trp Asn 
465                 470                 475                 480 


Phe Lys Asp Val Val Asp Glu Glu Ala Ser Ala Gln Ala Phe Ile Glu 
                485                 490                 495     


Gly Met Thr Asn Tyr Asp Thr Tyr Leu Pro Glu Glu Lys Val Leu Pro 
            500                 505                 510         


Lys His Ser Pro Leu Tyr Glu Met Phe Thr Val Tyr Asn Glu Leu Thr 
        515                 520                 525             


Lys Val Lys Tyr Ile Ala Glu Asn Met Thr Lys Pro Leu Tyr Leu Ser 
    530                 535                 540                 


Ala Glu Gln Lys Glu Ala Ile Ile Asp His Leu Phe Lys Gln Thr Arg 
545                 550                 555                 560 


Lys Val Thr Val Lys Asp Leu Lys Glu Lys Tyr Phe Ser Gln Ile Glu 
                565                 570                 575     


Gly Leu Glu Asn Val Asp Val Thr Gly Val Glu Gly Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr Asn Asp Leu Leu Lys Ile Ile Lys Asp Lys Ala 
        595                 600                 605             


Phe Leu Asp Asp Glu Ala Asn Ala Glu Ile Leu Glu Glu Ile Val Leu 
    610                 615                 620                 


Ile Leu Thr Leu Phe Gln Asp Glu Lys Leu Ile Glu Lys Arg Leu Ala 
625                 630                 635                 640 


Lys Tyr Ala Asn Leu Phe Glu Lys Ser Val Leu Lys Lys Leu Arg Lys 
                645                 650                 655     


Arg His Tyr Arg Gly Trp Gly Arg Leu Ser Arg Gln Leu Ile Asp Gly 
            660                 665                 670         


Met Lys Asp Lys Ala Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ala 
        675                 680                 685             


Asp Asp Phe Ala Asn Arg Asn Phe Ile Gln Leu Ile Asn Asp Ser Ser 
    690                 695                 700                 


Leu Asp Phe Glu Lys Leu Ile Asp Asp Ala Gln Lys Lys Ala Ile Lys 
705                 710                 715                 720 


Arg Glu Ser Leu Thr Glu Ala Val Ala Asn Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Val Val Asp Glu Ile Val 
            740                 745                 750         


Lys Val Met Gly His Asn Pro Asp Asn Ile Val Ile Glu Met Ser Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Ala Gln Gly Leu Lys Asn Ala Arg Gln Arg Leu 
    770                 775                 780                 


Lys Lys Ile Lys Glu Val His Lys Lys Thr Gly Ser Arg Ile Leu Glu 
785                 790                 795                 800 


Asp Asn Ser Glu Arg Ile Thr Asn Leu Thr Leu Gln Asp Asn Arg Leu 
                805                 810                 815     


Tyr Leu Tyr Leu Leu Gln Asp Gly Lys Asp Met Tyr Thr Gly Gln Asp 
            820                 825                 830         


Leu Asp Ile Asn Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ser Phe Ile Lys Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Thr 
    850                 855                 860                 


Gln Lys Ala Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Glu Val 
865                 870                 875                 880 


Val Arg Asp Met Lys Asp Arg Val Trp Arg Arg Gln Leu Ala Asn Gly 
                885                 890                 895     


Ala Ile Ser Arg Gln Lys Phe Asp His Leu Thr Lys Ala Glu Arg Gly 
            900                 905                 910         


Gly Leu Ala Asp Ser Asp Lys Ala Arg Phe Leu Arg Arg Gln Leu Val 
        915                 920                 925             


Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Leu Leu Asp Ser Arg 
    930                 935                 940                 


Phe Asn Ser Lys Ser Asn Gln Asn Lys Lys Leu Ala Arg Asn Val Lys 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ser Lys Ile Val Ser Asp Phe Arg Lys Asp Phe 
                965                 970                 975     


Gly Leu Tyr Lys Leu Arg Glu Val Asn Asn Tyr His His Ala His Asp 
            980                 985                 990         


Ala Tyr Leu Asn Ala Val Val Gly  Thr Ala Leu Leu Lys  Lys Tyr Pro 
        995                 1000                 1005             


Lys Leu  Glu Ala Glu Phe Val  Tyr Gly Asp Tyr Lys  His Phe Asp 
    1010                 1015                 1020             


Leu Val  Lys Leu Ile Ser Lys  Ser Asp Pro Ser Leu  Gly Lys Ala 
    1025                 1030                 1035             


Thr Ala  Lys Val Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1040                 1045                 1050             


Glu Glu  Leu Ser Leu Ala Asp  Gly Thr Leu Met Lys  Arg Pro Val 
    1055                 1060                 1065             


Ile Glu  Thr Asn Thr Glu Thr  Gly Glu Val Val Trp  Asp Lys Val 
    1070                 1075                 1080             


Lys Asp  Phe Lys Thr Ile Arg  Lys Val Leu Ser Tyr  Pro Gln Val 
    1085                 1090                 1095             


Asn Ile  Val Lys Lys Thr Glu  Ile Gln Ser Gly Ala  Phe Ser Lys 
    1100                 1105                 1110             


Glu Ser  Val Leu Ser Lys Gly  Asn Ser Asp Lys Leu  Ile Glu Arg 
    1115                 1120                 1125             


Lys Lys  Gly Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1130                 1135                 1140             


Asn Thr  Ala Tyr Ser Ile Phe  Val Val Ala Lys Val  Ala Lys Arg 
    1145                 1150                 1155             


Lys Ala  Gln Lys Leu Lys Thr  Val Lys Glu Ile Val  Gly Ile Thr 
    1160                 1165                 1170             


Ile Met  Glu Gln Ala Glu Tyr  Glu Lys Asp Asn Ile  Ala Phe Leu 
    1175                 1180                 1185             


Glu Lys  Lys Gly Tyr Gln Asp  Ile Gln Glu Lys Leu  Leu Ile Lys 
    1190                 1195                 1200             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg 
    1205                 1210                 1215             


Leu Leu  Ala Ser Ala Asn Glu  Phe Gln Lys Gly Asn  Glu Leu Ala 
    1220                 1225                 1230             


Leu Ser  Gly Lys Tyr Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr 
    1235                 1240                 1245             


Asp Lys  Leu Ser Ser Lys Ile  Glu Ser Glu Gln Gln  Lys Lys Leu 
    1250                 1255                 1260             


Phe Val  Glu Gln His Leu His  Tyr Phe Asp Glu Ile  Leu Asp Ile 
    1265                 1270                 1275             


Val Val  Lys His Ala Thr Cys  Tyr Ile Lys Ala Glu  Asn Asn Leu 
    1280                 1285                 1290             


Lys Lys  Ile Ile Ser Leu Tyr  Lys Lys Lys Glu Ala  Tyr Ser Ile 
    1295                 1300                 1305             


Asn Glu  Gln Ala Leu Asn Met  Leu Asn Leu Phe Ile  Phe Thr Ser 
    1310                 1315                 1320             


Leu Gly  Ala Pro Ser Thr Phe  Val Phe Phe Asp Glu  Thr Ile Asp 
    1325                 1330                 1335             


Arg Lys  Arg Tyr Thr Thr Ser  Ser Asp Val Leu Asn  Gly Ile Leu 
    1340                 1345                 1350             


Ile Gln  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1355                 1360                 1365             


Ser Arg  Phe Gly Gly Asp 
    1370                 


<210>  223
<211>  1326
<212>  PRT
<213>  Streptococcus pseudoporcinus

<400>  223

Met Leu Gly Thr Val Leu Phe Asp Ser Gly Glu Thr Ala Gln Ala Arg 
1               5                   10                  15      


Arg Leu Lys Arg Thr Asn Arg Arg Arg Tyr Thr Arg Arg Arg Tyr Arg 
            20                  25                  30          


Leu Cys Gln Leu Gln Asn Ile Phe Ala Thr Glu Met Val Lys Val Asp 
        35                  40                  45              


Asp Thr Phe Phe Gln Arg Leu Ser Glu Ser Phe Phe Tyr Tyr Gln Asp 
    50                  55                  60                  


Lys Ala Phe Asp Lys His Pro Ile Phe Gly Asn Ser Lys Glu Glu Arg 
65                  70                  75                  80  


Ala Tyr His Lys Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Asp Leu 
                85                  90                  95      


Ala Asp Arg Asp Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 
            100                 105                 110         


Ser His Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Leu 
        115                 120                 125             


Asn Ser Glu Asn Thr Asp Val Gln Lys Leu Phe Ile Ala Leu Val Thr 
    130                 135                 140                 


Val Tyr Asn Leu Leu Phe Glu Glu Glu Pro Ile Ala Gly Glu Thr Cys 
145                 150                 155                 160 


Asp Ala Lys Ala Leu Leu Thr Ala Lys Thr Ser Lys Ser Lys Arg Leu 
                165                 170                 175     


Glu Ser Leu Ile Ser Glu Phe Pro Gly Gln Lys Lys Asn Gly Leu Phe 
            180                 185                 190         


Gly Asn Leu Leu Ala Leu Ala Leu Gly Leu Arg Pro Asn Phe Lys Ser 
        195                 200                 205             


Asn Phe Gly Leu Ser Glu Asp Ala Lys Leu Gln Ile Thr Lys Asp Thr 
    210                 215                 220                 


Tyr Glu Glu Glu Leu Asp Asn Leu Leu Ala Glu Ile Gly Asp His Tyr 
225                 230                 235                 240 


Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu 
                245                 250                 255     


Ser Asp Ile Leu Thr Leu Ser Asp Glu Asn Thr Arg Ala Pro Leu Ser 
            260                 265                 270         


Ala Ser Met Ile Lys Arg Tyr Glu Glu His Gln Glu Asp Leu Ala Leu 
        275                 280                 285             


Leu Lys Lys Leu Val Lys Glu Gln Met Pro Glu Lys Tyr Trp Glu Ile 
    290                 295                 300                 


Phe Ser Asn Ala Lys Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Gly Lys 
305                 310                 315                 320 


Val Ser Gln Glu Asp Phe Tyr Arg Tyr Ile Lys Pro Ile Leu Ser Arg 
                325                 330                 335     


Leu Lys Gly Gly Asp Glu Phe Leu Ala Lys Ile Asp Arg Asp Asp Phe 
            340                 345                 350         


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile 
        355                 360                 365             


His Leu Lys Glu Leu His Ala Ile Leu Arg Arg Gln Glu Lys Tyr Tyr 
    370                 375                 380                 


Pro Phe Leu Ala Glu Gln Lys Glu Lys Ile Glu Gln Leu Leu Cys Phe 
385                 390                 395                 400 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Gly Gly Asn Ser Ser 
                405                 410                 415     


Phe Ala Trp Leu Lys Arg Arg Ser Asp Glu Pro Ile Thr Pro Trp Asn 
            420                 425                 430         


Phe Lys Asp Val Val Asp Glu Glu Ala Ser Ala Gln Ala Phe Ile Glu 
        435                 440                 445             


Gly Met Thr Asn Tyr Asp Thr Tyr Leu Pro Glu Glu Lys Val Leu Pro 
    450                 455                 460                 


Lys His Ser Pro Leu Tyr Glu Met Phe Thr Val Tyr Asn Glu Leu Thr 
465                 470                 475                 480 


Lys Val Lys Tyr Ile Ala Glu Asn Met Thr Lys Pro Leu Tyr Leu Ser 
                485                 490                 495     


Ala Glu Gln Lys Glu Ala Ile Ile Asp His Leu Phe Lys Gln Thr Arg 
            500                 505                 510         


Lys Val Thr Val Lys Asp Leu Lys Glu Lys Tyr Phe Ser Gln Ile Glu 
        515                 520                 525             


Gly Leu Glu Asn Val Asp Val Thr Gly Val Glu Gly Ala Phe Asn Ala 
    530                 535                 540                 


Ser Leu Gly Thr Tyr Asn Asp Leu Leu Lys Ile Ile Lys Asp Lys Ala 
545                 550                 555                 560 


Phe Leu Asp Asp Glu Ala Asn Ala Glu Ile Leu Glu Glu Ile Val Leu 
                565                 570                 575     


Ile Leu Thr Leu Phe Gln Asp Glu Lys Leu Ile Glu Lys Arg Leu Ala 
            580                 585                 590         


Lys Tyr Ala Asn Leu Phe Glu Lys Ser Val Leu Lys Lys Leu Arg Lys 
        595                 600                 605             


Arg His Tyr Arg Gly Trp Gly Arg Leu Ser Arg Gln Leu Ile Asp Gly 
    610                 615                 620                 


Met Lys Asp Lys Ala Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ala 
625                 630                 635                 640 


Asp Asp Phe Ala Asn Arg Asn Phe Ile Gln Leu Ile Asn Asp Ser Ser 
                645                 650                 655     


Leu Asp Phe Glu Lys Leu Ile Asp Asp Ala Gln Lys Lys Ala Ile Lys 
            660                 665                 670         


Arg Glu Ser Leu Thr Glu Ala Val Ala Asn Leu Ala Gly Ser Pro Ala 
        675                 680                 685             


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Val Val Asp Glu Ile Val 
    690                 695                 700                 


Lys Val Met Gly His Asn Pro Asp Asn Ile Val Ile Glu Met Ser Arg 
705                 710                 715                 720 


Glu Asn Gln Thr Thr Ala Gln Gly Leu Lys Asn Ala Arg Gln Arg Leu 
                725                 730                 735     


Lys Lys Ile Lys Glu Val His Lys Lys Thr Gly Ser Arg Ile Leu Glu 
            740                 745                 750         


Asp Asn Ser Glu Arg Ile Thr Asn Leu Thr Leu Gln Asp Asn Arg Leu 
        755                 760                 765             


Tyr Leu Tyr Leu Leu Gln Asp Gly Lys Asp Met Tyr Thr Gly Gln Asp 
    770                 775                 780                 


Leu Asp Ile Asn Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
785                 790                 795                 800 


Gln Ser Phe Ile Lys Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Thr 
                805                 810                 815     


Gln Lys Ala Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Glu Val 
            820                 825                 830         


Val Arg Asp Met Lys Asp Arg Val Trp Arg Arg Gln Leu Ala Asn Gly 
        835                 840                 845             


Ala Ile Ser Arg Gln Lys Phe Asp His Leu Thr Lys Ala Glu Arg Gly 
    850                 855                 860                 


Gly Leu Ala Asp Ser Asp Lys Ala Arg Phe Leu Arg Arg Gln Leu Val 
865                 870                 875                 880 


Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Leu Leu Asp Ser Arg 
                885                 890                 895     


Phe Asn Ser Lys Ser Asn Gln Asn Lys Lys Leu Ala Arg Asn Val Lys 
            900                 905                 910         


Ile Ile Thr Leu Lys Ser Lys Ile Val Ser Asp Phe Arg Lys Asp Phe 
        915                 920                 925             


Gly Leu Tyr Lys Leu Arg Glu Val Asn Asn Tyr His His Ala His Asp 
    930                 935                 940                 


Ala Tyr Leu Asn Ala Val Val Gly Thr Ala Leu Leu Lys Lys Tyr Pro 
945                 950                 955                 960 


Lys Leu Glu Ala Glu Phe Val Tyr Gly Asp Tyr Lys His Phe Asp Leu 
                965                 970                 975     


Val Lys Leu Ile Ser Lys Ser Asp Pro Ser Leu Gly Lys Ala Thr Ala 
            980                 985                 990         


Lys Val Phe Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Glu Glu Leu 
        995                 1000                 1005             


Ser Leu  Ala Asp Gly Thr Leu  Met Lys Arg Pro Val  Ile Glu Thr 
    1010                 1015                 1020             


Asn Thr  Glu Thr Gly Glu Val  Val Trp Asp Lys Val  Lys Asp Phe 
    1025                 1030                 1035             


Lys Thr  Ile Arg Lys Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val 
    1040                 1045                 1050             


Lys Lys  Thr Glu Ile Gln Ser  Gly Ala Phe Ser Lys  Glu Ser Val 
    1055                 1060                 1065             


Leu Ser  Lys Gly Asn Ser Asp  Lys Leu Ile Glu Arg  Lys Lys Gly 
    1070                 1075                 1080             


Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp Ser Pro  Asn Thr Ala 
    1085                 1090                 1095             


Tyr Ser  Ile Phe Val Val Ala  Lys Val Ala Lys Arg  Lys Ala Gln 
    1100                 1105                 1110             


Lys Leu  Lys Thr Val Lys Glu  Ile Val Gly Ile Thr  Ile Met Glu 
    1115                 1120                 1125             


Gln Ala  Glu Tyr Glu Lys Asp  Asn Ile Ala Phe Leu  Glu Lys Lys 
    1130                 1135                 1140             


Gly Tyr  Gln Asp Ile Gln Glu  Lys Leu Leu Ile Lys  Leu Pro Lys 
    1145                 1150                 1155             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Arg Arg  Leu Leu Ala 
    1160                 1165                 1170             


Ser Ala  Asn Glu Phe Gln Lys  Gly Asn Glu Leu Ala  Leu Ser Gly 
    1175                 1180                 1185             


Lys Tyr  Met Lys Phe Leu Tyr  Leu Ala Ser Arg Tyr  Asp Lys Leu 
    1190                 1195                 1200             


Ser Ser  Lys Ile Glu Ser Glu  Gln Gln Lys Lys Leu  Phe Val Glu 
    1205                 1210                 1215             


Gln His  Leu His Tyr Phe Asp  Glu Ile Leu Asp Ile  Val Val Lys 
    1220                 1225                 1230             


His Ala  Thr Cys Tyr Ile Lys  Ala Glu Asn Asn Leu  Lys Lys Ile 
    1235                 1240                 1245             


Ile Ser  Leu Tyr Lys Lys Lys  Glu Ala Tyr Ser Ile  Asn Glu Gln 
    1250                 1255                 1260             


Ala Leu  Asn Met Leu Asn Leu  Phe Ile Phe Thr Ser  Leu Gly Ala 
    1265                 1270                 1275             


Pro Ser  Thr Phe Val Phe Phe  Asp Glu Thr Ile Asp  Arg Lys Arg 
    1280                 1285                 1290             


Tyr Thr  Thr Ser Ser Asp Val  Leu Asn Gly Ile Leu  Ile Gln Gln 
    1295                 1300                 1305             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Arg Phe 
    1310                 1315                 1320             


Gly Gly  Asp 
    1325     


<210>  224
<211>  1370
<212>  PRT
<213>  Streptococcus sanguinis

<400>  224

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Phe Gly Asp Thr Asp Arg Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Thr Leu Leu Phe Asp Asp Gly Asn Thr Ala Glu Ser Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Thr Glu Ser Met Asn Glu Ile Asp Glu Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Glu Tyr 
        115                 120                 125             


His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala Asp 
    130                 135                 140                 


Ser Lys Glu Lys Ser Asp Val Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Thr Phe Asp Ile 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Asn Ile Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln Val 
        195                 200                 205             


Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Glu Glu Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala Asp 
        275                 280                 285             


Leu Phe Leu Ile Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Ala Leu Lys 
                325                 330                 335     


Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Val Glu Val Phe Ser 
            340                 345                 350         


Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Thr 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Asp Asn Arg Asp Phe Ser Trp 
    450                 455                 460                 


Leu Thr Arg Asn Ser Asp Glu Pro Ile Arg Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Ala Arg Ser Ala Glu Asp Phe Ile His Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly Gln 
    530                 535                 540                 


Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Glu Lys Arg Lys Val Thr 
545                 550                 555                 560 


Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Asn Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Thr Lys Asp Lys Glu Phe Met Asp Asp 
        595                 600                 605             


Pro Lys Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp Thr 
625                 630                 635                 640 


Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Asp Lys Ile 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe Lys 
    690                 695                 700                 


Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asp Asp Val Lys 
705                 710                 715                 720 


Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Ala Leu Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu Asp 
    770                 775                 780                 


Ala Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Asn Ile Leu Lys Glu 
785                 790                 795                 800 


Asn Pro Thr Asp Asn Ile Gln Leu Lys Asn Asp Arg Leu Phe Leu Tyr 
                805                 810                 815     


Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Lys Pro Leu Asp Ile 
            820                 825                 830         


Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe 
        835                 840                 845             


Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Asp 
    850                 855                 860                 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Gln Lys 
865                 870                 875                 880 


Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser Glu 
                885                 890                 895     


Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp Glu 
            900                 905                 910         


Arg Asp Lys Val Gly Phe Ile Arg Arg Gln Leu Val Glu Thr Gln Gln 
        915                 920                 925             


Ile Thr Lys Asn Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Thr Glu 
    930                 935                 940                 


Val Lys Glu Lys Asn Gln Lys Ile Arg Thr Val Lys Ile Ile Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Ala Lys Ala Ile Leu  Lys Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Asp Tyr  Gln Lys Tyr Asp Leu  Lys Lys Tyr 
    1010                 1015                 1020             


Ile Ser  Arg Phe Lys Pro Ser  Lys Glu Ile Glu Lys  Ala Thr Glu 
    1025                 1030                 1035             


Lys Tyr  Phe Phe Tyr Ser Asn  Leu Leu Asn Phe Phe  Lys Glu Glu 
    1040                 1045                 1050             


Val Leu  Tyr Ala Asp Gly Thr  Ile Arg Lys Arg Glu  Asn Ile Glu 
    1055                 1060                 1065             


Tyr Ser  Lys Asp Thr Gly Glu  Ile Ala Trp Asp Lys  Glu Lys Asp 
    1070                 1075                 1080             


Phe Ala  Thr Ile Lys Lys Val  Leu Ser Tyr Pro Gln  Val Asn Ile 
    1085                 1090                 1095             


Val Lys  Lys Arg Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1100                 1105                 1110             


Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu Ile Pro  Arg Lys Thr 
    1115                 1120                 1125             


Lys Asp  Ile Leu Trp Asp Thr  Thr Lys Tyr Gly Gly  Phe Asp Ser 
    1130                 1135                 1140             


Pro Val  Ile Ala Tyr Ser Ile  Leu Leu Ile Ala Asp  Ile Glu Lys 
    1145                 1150                 1155             


Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys Thr Leu  Val Gly Ile 
    1160                 1165                 1170             


Thr Ile  Met Glu Lys Ala Ala  Phe Glu Glu Asn Pro  Ile Thr Phe 
    1175                 1180                 1185             


Leu Glu  Asn Lys Gly Tyr His  Asn Val Arg Lys Glu  Asn Ile Leu 
    1190                 1195                 1200             


Cys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Arg 
    1205                 1210                 1215             


Arg Leu  Leu Ala Ser Ala Lys  Glu Leu Gln Lys Gly  Asn Glu Ile 
    1220                 1225                 1230             


Val Leu  Pro Val Cys Leu Thr  Thr Leu Leu Tyr His  Ser Lys Asn 
    1235                 1240                 1245             


Leu His  Lys Leu Asp Glu Pro  Glu His Leu Glu Tyr  Ile Gln Lys 
    1250                 1255                 1260             


His Arg  Asn Glu Phe Lys Asp  Leu Leu Asn Leu Val  Ser Glu Phe 
    1265                 1270                 1275             


Ser Gln  Lys Tyr Ile Leu Ala  Glu Ala Asn Leu Glu  Lys Ile Lys 
    1280                 1285                 1290             


Asp Leu  Tyr Ala Asp Asn Glu  Gln Ala Asp Ile Glu  Ile Leu Ala 
    1295                 1300                 1305             


Asn Ser  Phe Ile Asn Leu Leu  Thr Phe Thr Ala Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Gly  Lys Asp Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Thr  Val Ser Glu Ile Leu  Asn Ala Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1355                 1360                 1365             


Glu Glu  
    1370 


<210>  225
<211>  1377
<212>  PRT
<213>  Streptococcus sanguinis

<400>  225

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ser Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Ile Ser Lys Leu Asp Ser Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Glu Glu Glu Lys Glu Tyr 
        115                 120                 125             


His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp Ile 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln Val 
        195                 200                 205             


Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Thr Lys Arg Glu Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Ser Asp Glu Lys Ser Thr Gly Leu Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Gly Phe Ala Asp 
        275                 280                 285             


Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Glu Arg Tyr Glu Asn His Gln Glu Asp Leu Ala Ala Leu Lys 
                325                 330                 335     


Gln Phe Ile Lys Asn Asn Leu Ser Glu Lys Tyr Ala Glu Val Phe Ser 
            340                 345                 350         


Asp Gln Ser Lys Asp Gly Tyr Ala Gly Phe Ile Asp Gly Lys Thr Thr 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Leu Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Asn Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Leu Phe 
            420                 425                 430         


Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Ala Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala Trp 
    450                 455                 460                 


Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly Gln 
    530                 535                 540                 


Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp Asn 
        595                 600                 605             


Pro Lys Asn Gly Glu Ile Leu Glu Asn Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp Thr 
625                 630                 635                 640 


Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Thr Gly Lys Thr Ile Leu Glu Tyr Leu Ile Asp Asp Gly Asp Cys 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe Lys 
    690                 695                 700                 


Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asp Asp Val Lys 
705                 710                 715                 720 


Gln Val Val Gln Glu Ile Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His 
            740                 745                 750         


Asn Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu Asp 
    770                 775                 780                 


Ala Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Asn Ile Leu Lys Glu 
785                 790                 795                 800 


Asn Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr 
                805                 810                 815     


Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Lys Ala Ile Asp Ile 
            820                 825                 830         


Asn Gln Leu Ser Asn Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe 
        835                 840                 845             


Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys Asp 
    850                 855                 860                 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Glu Val Val Gln Lys 
865                 870                 875                 880 


Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser Glu 
                885                 890                 895     


Arg Lys Phe Asn Asn Leu Thr Lys Ala Lys Arg Gly Gly Leu Asp Glu 
            900                 905                 910         


Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Gln Leu Leu Asp Thr Arg Phe Asn Thr Glu 
    930                 935                 940                 


Val Asn Glu Glu Asn Gln Lys Ile Arg Thr Val Lys Ile Ile Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Ala Lys Ala Ile Leu  Lys Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Asp Tyr  Gln Lys Tyr Asp Leu  Lys Arg Tyr 
    1010                 1015                 1020             


Ile Leu  Lys Ser Lys Ala Ser  Asn Thr Ile Asp Lys  Ala Thr Glu 
    1025                 1030                 1035             


Lys Tyr  Phe Phe Tyr Ser Asn  Leu Leu Asn Phe Phe  Lys Glu Lys 
    1040                 1045                 1050             


Val Arg  Tyr Ala Asp Gly Thr  Ile Lys Lys Arg Glu  Asn Ile Glu 
    1055                 1060                 1065             


Tyr Ser  Asn Asp Thr Gly Glu  Ile Ala Trp Asn Lys  Glu Lys Asp 
    1070                 1075                 1080             


Phe Ala  Thr Ile Lys Lys Val  Leu Ser Leu Pro Gln  Val Asn Ile 
    1085                 1090                 1095             


Val Lys  Lys Thr Glu Glu Gln  Thr Val Gly Gln Asn  Gly Gly Leu 
    1100                 1105                 1110             


Phe Asp  Asn Asn Ile Val Ser  Lys Lys Lys Val Val  Asp Ala Ser 
    1115                 1120                 1125             


Lys Leu  Ile Pro Ile Lys Ser  Ser Leu Ser Pro Glu  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Arg Pro Thr Ile  Ala Tyr Ser Val Leu  Val Ile Ala 
    1145                 1150                 1155             


Asp Ile  Glu Lys Gly Lys Gly  Lys Ala Lys Lys Leu  Lys Arg Ile 
    1160                 1165                 1170             


Lys Glu  Ile Val Gly Ile Thr  Ile Gln Asp Lys Lys  Lys Phe Glu 
    1175                 1180                 1185             


Ser Asn  Pro Val Thr Tyr Leu  Glu Glu Cys Gly Tyr  Lys Asn Ile 
    1190                 1195                 1200             


Asn Ser  Asn Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1205                 1210                 1215             


Phe Asn  Asp Gly Gln Arg Arg  Leu Leu Ala Ser Ser  Ile Glu Leu 
    1220                 1225                 1230             


Gln Lys  Gly Asn Glu Leu Ile  Leu Pro Tyr His Leu  Thr Ala Leu 
    1235                 1240                 1245             


Leu Tyr  His Ala Gln Arg Ile  Asn Lys Ile Ser Glu  Pro Ile His 
    1250                 1255                 1260             


Lys Gln  Tyr Val Glu Ala His  Gln Asn Glu Phe Lys  Glu Leu Leu 
    1265                 1270                 1275             


Thr Thr  Ile Ile Ser Leu Ser  Lys Lys Tyr Ile Gln  Lys Pro Asn 
    1280                 1285                 1290             


Val Glu  Leu Leu Leu Gln Gln  Ala Phe Asp Gln Ala  Asp Lys Asp 
    1295                 1300                 1305             


Ile Tyr  Gln Leu Ser Glu Ser  Phe Ile Ser Leu Leu  Lys Leu Thr 
    1310                 1315                 1320             


Ser Phe  Gly Ala Pro Gly Ala  Phe Lys Phe Leu Gly  Val Glu Ile 
    1325                 1330                 1335             


Ser Gln  Ser Ser Val Arg Tyr  Lys Pro Asn Ser Gln  Phe Leu Asp 
    1340                 1345                 1350             


Thr Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Ser Lys Leu Gly  Glu Asp 
    1370                 1375         


<210>  226
<211>  1371
<212>  PRT
<213>  Unknown

<220>
<223>  Streptococcus sp. F0441

<400>  226

Met Glu Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ser Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Ala Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ser Glu Glu Ile Gly Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Ile Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ala Glu Glu Lys Lys 
        115                 120                 125             


Tyr His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ala Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asn Asn Thr Phe Glu Gly Asn Ser Leu Ser Gly Gln Asn Val Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Arg Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asn Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Ser Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Glu Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Thr Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Thr Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Gln Phe Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Ala Phe Met Asp 
        595                 600                 605             


Asp Ala Lys Asn Glu Ala Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp 
625                 630                 635                 640 


Ser Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Ser Asp 
            660                 665                 670         


Lys Gln Thr Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Glu 
        675                 680                 685             


Ile Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asn Asp Val 
705                 710                 715                 720 


Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ser Leu Lys Ile Leu Ala Ser Gly Leu Asn Ser Lys Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Cys Asp Ile Asp His Ile Ile Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Asp 
865                 870                 875                 880 


Lys Met Lys Val Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Tyr Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asn 
            900                 905                 910         


Glu Leu Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Lys 
    930                 935                 940                 


Glu Val Thr Glu Lys Asp Lys Lys Asn Arg Thr Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Arg Ser Lys Asp  Pro Lys Glu Ile Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Thr Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Ala Thr Ile Lys Lys  Val Leu Ser Leu Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Arg Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Pro Lys Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Asp Ile Leu Trp Asp  Thr Thr Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Val Ile Ala Tyr Ser  Ile Leu Leu Ile Ala  Asp Ile Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ala Lys Lys Leu  Lys Thr Val Lys Thr  Leu Val Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Lys Asp  Ala Phe Glu Lys Asn  Pro Ile Ala 
    1175                 1180                 1185             


Phe Leu  Glu Asn Lys Gly Tyr  His Asn Val Cys Lys  Glu Asn Ile 
    1190                 1195                 1200             


Leu Cys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Leu Gln Lys  Cys Asn Glu 
    1220                 1225                 1230             


Ile Val  Leu Pro Val Tyr Leu  Thr Thr Leu Leu Tyr  His Ser Lys 
    1235                 1240                 1245             


Asn Val  His Lys Leu Asp Glu  Pro Gly His Leu Glu  Tyr Ile Gln 
    1250                 1255                 1260             


Lys His  Arg Asn Glu Phe Lys  Asp Leu Leu Asn Leu  Val Ser Glu 
    1265                 1270                 1275             


Phe Ser  Gln Lys Tyr Val Leu  Ala Asp Ala Asn Leu  Glu Lys Ile 
    1280                 1285                 1290             


Lys Asn  Leu Tyr Ala Asp Asn  Glu Gln Ala Asp Ile  Glu Ile Leu 
    1295                 1300                 1305             


Ala Asn  Ser Phe Ile Asn Leu  Leu Thr Phe Thr Ala  Leu Gly Ala 
    1310                 1315                 1320             


Pro Ala  Ala Phe Lys Phe Phe  Gly Lys Asp Val Asp  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Thr  Thr Val Ser Glu Ile  Leu Asn Ala Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1355                 1360                 1365             


Gly Glu  Asp 
    1370     


<210>  227
<211>  1361
<212>  PRT
<213>  Unknown

<220>
<223>  Streptococcus sp. FF10

<400>  227

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Met 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Asp Ile Phe Ser Pro Glu Leu Asn Gln Val Asp Glu Ser 
                85                  90                  95      


Phe Leu His Arg Leu Asp Asp Ser Phe Leu Val Ala Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Val Ile Phe Gly Asn Ile Ala Asp Glu Val Lys Tyr 
        115                 120                 125             


His Lys Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly His Phe Leu Ile Asp Glu Pro Ile Asp Ile 
                165                 170                 175     


Arg Asn Met Asn Ser Gln Asn Leu Phe Lys Glu Phe Leu Leu Ala Phe 
            180                 185                 190         


Asp Gly Ile Gln Val Asp Cys Tyr Leu Ala Ser Lys His Thr Asp Ile 
        195                 200                 205             


Ser Gly Ile Ile Thr Ala Lys Ile Ser Lys Ser Arg Lys Val Glu Ala 
    210                 215                 220                 


Val Leu Glu Gln Phe Pro Asp Gln Lys Lys Asn Ser Phe Phe Gly Asn 
225                 230                 235                 240 


Met Val Ser Leu Val Phe Gly Leu Met Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Glu Leu Asp Glu Asp Ala Lys Leu Gln Phe Ser Arg Asp Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Asn Leu Leu Gly Ile Ile Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Val Phe Val Ala Ala Lys Lys Val Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Thr Asn Asn His Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Asp Arg Tyr Asp Glu His Asn Ser Asp Lys Lys Leu Leu Arg 
                325                 330                 335     


Asp Phe Ile Arg Thr Asn Ile Gly Lys Glu Val Phe Lys Glu Val Phe 
            340                 345                 350         


Tyr Asp Thr Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Asp Phe Tyr Lys Tyr Leu Lys Asn Leu Leu Gln Lys Val 
    370                 375                 380                 


Asp Gly Gly Asp Tyr Phe Ile Glu Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Asp Glu Met Lys Ala Ile Leu Arg Arg Gln Gly Glu Phe Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Ala Glu Lys Ile Gln Gln Ile Leu Thr Phe Lys 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala 
    450                 455                 460                 


Trp Ala Ser Tyr Asn Ser Asn Glu Lys Met Thr Pro Trp Asn Phe Asp 
465                 470                 475                 480 


Asn Val Ile Asp Lys Thr Ser Ser Ala Gln Ala Phe Ile Glu Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Asp Gln Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Gln Lys Phe Ala Val Tyr Asn Glu Leu Thr Lys Ile 
        515                 520                 525             


Lys Tyr Val Thr Glu Thr Gly Glu Ala Arg Leu Phe Asp Val Phe Leu 
    530                 535                 540                 


Lys Lys Glu Ile Phe Asp Gly Leu Phe Lys Lys Glu Arg Lys Val Thr 
545                 550                 555                 560 


Lys Lys Lys Ile Leu Asn Phe Leu Asp Lys Asn Phe Asp Glu Phe Arg 
                565                 570                 575     


Ile Thr Asp Ile Gln Gly Leu Asp Asn Glu Thr Gly Asn Phe Asn Ala 
            580                 585                 590         


Ser Tyr Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Gly Asp Lys Glu 
        595                 600                 605             


Phe Met Asp Ser Ser Asp Asn Val Asp Val Leu Glu Asp Ile Val Leu 
    610                 615                 620                 


Ser Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Leu 
625                 630                 635                 640 


Lys Tyr Glu Asp Ile Phe Ser Lys Lys Val Ile Ala Asn Leu Thr Arg 
                645                 650                 655     


Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly 
            660                 665                 670         


Ile Lys Asp Lys His Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp 
        675                 680                 685             


Asp Gly His Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Asn 
    690                 695                 700                 


Leu Ser Phe Lys Asp Glu Ile Ala Asn Ser Gln Val Ile Gly Asp Gly 
705                 710                 715                 720 


Asp Asp Leu His Gln Val Val Gln Glu Leu Ala Gly Ser Pro Ala Ile 
                725                 730                 735     


Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys 
            740                 745                 750         


Val Met Gly Tyr Asn Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu 
        755                 760                 765             


Asn Gln Thr Thr Ala Arg Gly Arg Asn Asn Ser Gln Gln Arg Leu Gly 
    770                 775                 780                 


Ser Leu Thr Lys Ala Ile Gln Asp Phe Gly Ser Asp Ile Leu Lys Arg 
785                 790                 795                 800 


Tyr Pro Val Glu Asn Asn Gln Leu Gln Asn Asp Gln Leu Tyr Leu Tyr 
                805                 810                 815     


Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Asp Thr Leu Asp Ile 
            820                 825                 830         


His Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe 
        835                 840                 845             


Ile Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Thr Asn Ser Lys Ser 
    850                 855                 860                 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Asn Glu Val Val Lys Arg 
865                 870                 875                 880 


Met Lys Gly Phe Trp Leu Lys Gln Leu Asp Ala Lys Leu Ile Ser Gln 
                885                 890                 895     


Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Ala 
            900                 905                 910         


Glu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Arg Asp 
    930                 935                 940                 


Phe Asp Lys Asn Asp Lys Arg Ile Arg Asn Val Lys Ile Val Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly Phe Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asn Phe His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Ala Lys Ala Leu Leu  Ile Arg Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu 
    1010                 1015                 1020             


Arg Lys  Ser Ala Thr Glu Lys  Met Phe Phe Tyr Ser  Asn Ile Met 
    1025                 1030                 1035             


Asn Met  Phe Lys Thr Thr Ile  Lys Leu Ala Asp Gly  Arg Val Val 
    1040                 1045                 1050             


Glu Lys  Pro Val Ile Glu Ala  Asn Glu Glu Thr Gly  Glu Ile Ala 
    1055                 1060                 1065             


Trp Asp  Lys Thr Lys His Phe  Ala Asn Val Lys Lys  Val Leu Ser 
    1070                 1075                 1080             


Tyr Pro  Gln Val Ser Ile Val  Lys Lys Val Glu Glu  Gln Thr Gly 
    1085                 1090                 1095             


Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys Gly Gly  Ser Asp Lys 
    1100                 1105                 1110             


Leu Ile  Ala Arg Lys Thr Lys  Asn Asn Tyr Leu Ser  Thr Gln Lys 
    1115                 1120                 1125             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Ile Met Phe 
    1130                 1135                 1140             


Val Ala  Asp Ile Glu Lys Gly  Lys Ser Lys Arg Leu  Lys Thr Val 
    1145                 1150                 1155             


Lys Glu  Met Ile Gly Ile Thr  Ile Met Glu Arg Ser  Arg Phe Glu 
    1160                 1165                 1170             


Ser Asn  Ser Val Thr Phe Leu  Glu Glu Lys Gly Tyr  Arg Asn Ile 
    1175                 1180                 1185             


Arg Glu  Asn Thr Ile Ile Lys  Phe Pro Lys Tyr Ser  Leu Phe Glu 
    1190                 1195                 1200             


Leu Glu  Asn Gly Arg Arg Arg  Leu Leu Ala Ser Ala  Ile Glu Leu 
    1205                 1210                 1215             


Gln Lys  Gly Asn Glu Met Phe  Leu Pro Gln Gln Phe  Val Asn Leu 
    1220                 1225                 1230             


Leu Tyr  His Ala Gln His Ala  Asn Lys Glu Asp Ser  Val Ile Tyr 
    1235                 1240                 1245             


Leu Glu  Lys His Arg His Glu  Leu Ser Glu Leu Phe  His His Ile 
    1250                 1255                 1260             


Ile Gly  Val Ser Glu Lys Thr  Ile Leu Lys Pro Lys  Val Glu Met 
    1265                 1270                 1275             


Thr Leu  Asn Glu Ala Phe Glu  Lys His Phe Glu Phe  Asp Glu Val 
    1280                 1285                 1290             


Ser Glu  Leu Ala Gln Ser Phe  Ile Ser Leu Leu Lys  Phe Thr Ala 
    1295                 1300                 1305             


Phe Gly  Ala Pro Gly Gly Phe  Lys Phe Leu Asp Ala  Asp Ile Lys 
    1310                 1315                 1320             


Gln Ser  Asn Leu Arg Tyr Gln  Thr Val Thr Glu Val  Leu Ser Ser 
    1325                 1330                 1335             


Thr Leu  Ile His Gln Ser Val  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1340                 1345                 1350             


Asp Leu  Ser Lys Leu Gly Gly  Glu 
    1355                 1360     


<210>  228
<211>  1375
<212>  PRT
<213>  Unknown

<220>
<223>  Streptococcus sp. M334

<400>  228

Met Ser Asn Lys Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Asp Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ser Gln Glu Ile Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Phe Phe Leu Val Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Val Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Ser Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Lys Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Thr Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Lys Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Ala Leu 
                325                 330                 335     


Lys Gln Phe Ile Gln Asn Asn Leu Gln Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Lys Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Ile Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Gln Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Gly Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Gln Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Thr Arg Tyr Gln Phe Leu Asp Lys Lys 
    530                 535                 540                 


Gln Lys Lys Asp Ile Phe Asp Thr Phe Phe Lys Ala Glu Asn Lys Arg 
545                 550                 555                 560 


Lys Val Thr Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly 
                565                 570                 575     


Tyr Asp Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser 
            580                 585                 590         


Leu Ser Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Ala Phe 
        595                 600                 605             


Met Asp Asp Ser Lys Asn Glu Glu Ile Leu Glu Asn Ile Ile His Thr 
    610                 615                 620                 


Leu Thr Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln 
625                 630                 635                 640 


Tyr Asp Ser Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Lys Ser Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Glu Ile Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Glu Ile Ile Gln Lys Ala Gln Val Phe Gly Lys Thr Asn 
705                 710                 715                 720 


Asp Val Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly His Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Ile Glu Asp Ser Leu Lys Asn Leu Ala Ser Gly Leu Asp Ser Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Asn Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Lys Pro 
            820                 825                 830         


Leu Glu Ile Asn Gln Leu Ser Asn Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Ser Lys Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val 
865                 870                 875                 880 


Val Glu Lys Met Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu 
                885                 890                 895     


Ile Ser Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Glu Arg 
            900                 905                 910         


Gly Gly Leu Asn Glu Leu Asp Lys Val Gly Phe Ile Lys Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Phe Leu Asp Ala 
    930                 935                 940                 


Arg Phe Asn Lys Glu Val Thr Glu Lys Asp Lys Lys Asn Arg Asn Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu 
                965                 970                 975     


Phe Gly Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Leu  Ala Lys Ala Ile Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Gln Lys Tyr 
    1010                 1015                 1020             


Asp Leu  Gln Arg Tyr Ile Ser  Lys Ser Arg Glu Pro  Lys Glu Val 
    1025                 1030                 1035             


Glu Lys  Ala Thr Gln Lys Tyr  Phe Phe Tyr Ser Asn  Leu Leu Asn 
    1040                 1045                 1050             


Phe Phe  Lys Glu Glu Val His  Tyr Ala Asp Gly Thr  Ile Val Lys 
    1055                 1060                 1065             


Arg Glu  Asn Ile Glu Tyr Ser  Lys Asp Thr Gly Glu  Ile Ala Trp 
    1070                 1075                 1080             


Asn Lys  Glu Lys Asp Phe Ala  Thr Val Lys Lys Val  Leu Ser Leu 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Thr Lys Glu  Ile Leu Trp Asp Thr  Thr Lys Tyr 
    1130                 1135                 1140             


Gly Gly  Phe Asp Ser Pro Val  Ile Ala Tyr Ser Ile  Leu Leu Ile 
    1145                 1150                 1155             


Ala Asp  Ile Glu Lys Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys 
    1160                 1165                 1170             


Thr Leu  Val Gly Ile Thr Ile  Met Glu Lys Ala Thr  Phe Glu Lys 
    1175                 1180                 1185             


Asn Pro  Ile Thr Phe Leu Glu  Asn Lys Gly Tyr His  Asn Val Arg 
    1190                 1195                 1200             


Lys Glu  Asn Ile Leu Cys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1205                 1210                 1215             


Glu Ser  Gly Arg Arg Arg Met  Leu Ala Ser Ala Lys  Glu Leu Gln 
    1220                 1225                 1230             


Lys Gly  Asn Glu Ile Val Leu  Pro Val Tyr Leu Thr  Thr Leu Leu 
    1235                 1240                 1245             


Tyr His  Ser Lys Asn Val His  Lys Leu Asp Glu Pro  Glu His Leu 
    1250                 1255                 1260             


Glu Tyr  Ile Gln Lys His Arg  Tyr Glu Phe Lys Asp  Leu Leu Asn 
    1265                 1270                 1275             


Leu Val  Ser Glu Phe Ser Gln  Lys Tyr Val Leu Ala  Asp Ala Asn 
    1280                 1285                 1290             


Leu Glu  Lys Ile Lys Asn Leu  Tyr Ala Asp Asn Glu  Gln Ala Asp 
    1295                 1300                 1305             


Ile Glu  Ile Leu Ala Asn Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1310                 1315                 1320             


Ala Leu  Gly Ala Pro Ala Ala  Phe Lys Phe Leu Gly  Lys Asp Val 
    1325                 1330                 1335             


Asp Arg  Lys Arg Tyr Thr Thr  Val Ser Glu Ile Leu  Asn Ala Thr 
    1340                 1345                 1350             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1355                 1360                 1365             


Leu Ser  Lys Leu Gly Glu Asp  
    1370                 1375 


<210>  229
<211>  1371
<212>  PRT
<213>  Unknown

<220>
<223>  Streptococcus sp. taxon 056

<400>  229

Met Asn Asn Asn Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Arg Val Leu Gly Asn Thr Asp Lys Arg Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Asp Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys 
            100                 105                 110         


Ser Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ala Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Ile Thr Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ala Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Asn Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Gly Lys Ile Ser Lys Ser Val Lys Arg Glu 
    210                 215                 220                 


His Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Ser Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Glu Asp Leu Ala Ala Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Ala Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Leu Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Ser Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Phe Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asn His Lys Asn Gln Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp 
625                 630                 635                 640 


Ser Ile Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Cys Asp 
            660                 665                 670         


Lys Lys Thr Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Tyr 
        675                 680                 685             


Asn Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asp Asp Leu 
705                 710                 715                 720 


Thr Gln Val Val Arg Glu Leu Ser Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Ile Met Gly 
            740                 745                 750         


Tyr Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Lys Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ala Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Thr Ile Ser Lys 
785                 790                 795                 800 


Glu Asn Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Lys 
865                 870                 875                 880 


Lys Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 
            900                 905                 910         


Glu Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Ala Arg Phe Asn Thr 
    930                 935                 940                 


Glu Val Ser Glu Lys Asn Gln Lys Ile Arg Ser Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Lys Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Lys Ser Lys Asp  Pro Lys Glu Val Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Thr Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Val Thr Ile Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Arg Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Pro Lys Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Asp Ile Leu Trp Asp  Thr Thr Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Val Ile Ala Tyr Ser  Ile Leu Leu Ile Ala  Asp Ile Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ala Lys Lys Leu  Lys Thr Val Lys Thr  Leu Val Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Lys Ala  Ala Phe Glu Lys Asn  Pro Ile Thr 
    1175                 1180                 1185             


Phe Leu  Glu Asn Lys Gly Tyr  His Asn Val Arg Lys  Glu Asn Ile 
    1190                 1195                 1200             


Leu Cys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Ile Val  Leu Pro Val Tyr Leu  Thr Thr Leu Leu Tyr  His Ser Lys 
    1235                 1240                 1245             


Asn Val  His Lys Leu Asp Glu  Pro Glu His Leu Glu  Tyr Ile Gln 
    1250                 1255                 1260             


Lys His  Arg Tyr Glu Phe Lys  Asp Leu Leu Asn Leu  Val Ser Glu 
    1265                 1270                 1275             


Phe Ser  Gln Lys Tyr Val Leu  Ala Glu Ala Asn Leu  Glu Lys Ile 
    1280                 1285                 1290             


Lys Ser  Leu Tyr Val Asp Asn  Glu Gln Ala Asp Ile  Glu Ile Leu 
    1295                 1300                 1305             


Ala Asn  Ser Phe Ile Asn Leu  Leu Thr Phe Thr Ala  Leu Gly Ala 
    1310                 1315                 1320             


Pro Ala  Ala Phe Lys Phe Phe  Gly Lys Asp Val Asp  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Thr  Thr Val Ser Glu Ile  Leu Asn Ala Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1355                 1360                 1365             


Gly Glu  Asp 
    1370     


<210>  230
<211>  1364
<212>  PRT
<213>  Streptococcus suis

<400>  230

Met Lys Lys Lys Tyr Ala Ile Gly Ile Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Phe Gly Asn Thr Glu Lys Arg Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Thr Leu Leu Phe Asp Glu Gly Asn Thr Ala Glu Asn Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Ile Asn Lys Ile Asp Asp Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Ile Val Glu Asp Lys Gln 
            100                 105                 110         


Gly Ser Lys His Pro Ile Phe Gly Thr Leu Gln Glu Glu Lys Lys Tyr 
        115                 120                 125             


His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala Asp 
    130                 135                 140                 


Ser Ser Gln Lys Ala Asp Ile Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly His Phe Leu Phe Glu Gly Asp Leu Lys Ser 
                165                 170                 175     


Glu Asn Lys Asp Val Gln His Leu Phe Asn Asp Phe Val Glu Met Phe 
            180                 185                 190         


Asp Lys Thr Val Glu Gly Ser Tyr Leu Ser Glu Asn Leu Pro Asn Val 
        195                 200                 205             


Ala Asp Val Leu Val Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Ile Leu His Tyr Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Phe Leu Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Glu Leu Ala Glu Asp Ala Lys Ile Gln Phe Ser Lys Glu Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ile Ala Thr Lys Ser Leu Tyr Asp Gly Ile Leu Leu Ala Gly 
    290                 295                 300                 


Ile Leu Ser Thr Thr Asp Ser Thr Thr Lys Ala Pro Leu Ser Ser Ser 
305                 310                 315                 320 


Met Val Asn Arg Tyr Glu Glu His Lys Lys Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Asn Phe Ile His Gln Asn Leu Ser Asp Ser Tyr Lys Glu Val Phe Asn 
            340                 345                 350         


Asp Lys Leu Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr Thr 
        355                 360                 365             


Gln Glu Asn Phe Tyr Arg Phe Ile Lys Lys Ala Ile Glu Lys Ile Glu 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Ile Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Val Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Glu Phe Ala Trp 
    450                 455                 460                 


Leu Asn Arg Lys Ser Asp Glu Lys Ile Arg Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Met Val Asp Lys Glu Thr Ser Ala Glu Asn Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Gln Tyr Leu Pro Asp Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Ala Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Phe Ile Ala Glu Gly Met Arg Asp Tyr Gln Phe Leu Asp Ser Gly Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Lys Thr Leu Phe Lys Thr Lys Arg Lys Val Thr 
545                 550                 555                 560 


Ala Lys Asp Ile Lys Ala Tyr Leu Glu Asn Ser Asn Gly Tyr Ala Gly 
                565                 570                 575     


Val Glu Leu Lys Gly Leu Glu Glu Gln Phe Asn Ala Ser Leu Pro Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Leu Arg Asp Lys Ala Phe Ile Asp Ala 
        595                 600                 605             


Glu Glu Asn Gln Glu Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Lys Tyr Lys Asp 
625                 630                 635                 640 


Ile Leu Thr Glu Glu Gln Arg Lys Lys Leu Glu Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Leu Asp Lys 
            660                 665                 670         


Val Thr Arg Lys Thr Ile Leu Gly Tyr Leu Ile Asp Asp Gly Thr Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Thr Leu Ser Phe Val 
    690                 695                 700                 


Asp Glu Ile Arg Leu Ala Gln Gly Ser Gly Glu Ala Glu Asp Tyr Arg 
705                 710                 715                 720 


Ala Glu Val Gln Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Ile Glu Val Met Gly Tyr 
            740                 745                 750         


Asp Pro Glu His Ile Val Val Glu Met Ala Arg Glu Asn Gln Phe Thr 
        755                 760                 765             


Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Tyr Lys Lys Ile Glu Asn 
    770                 775                 780                 


Ala Ile Lys Asn Leu Asp Ser Asn Leu Asn Ser Lys Ile Leu Lys Glu 
785                 790                 795                 800 


Tyr Pro Thr Asn Asn Gln Ala Leu Gln Asn Asp Arg Leu Phe Leu Tyr 
                805                 810                 815     


Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Glu Glu Leu Asp Ile 
            820                 825                 830         


Asp Gln Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe 
        835                 840                 845             


Ile Lys Asp Asp Ser Leu Asp Asn Lys Val Leu Thr Lys Ser Ala Lys 
    850                 855                 860                 


Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile Val His Lys 
865                 870                 875                 880 


Lys Lys Asn Phe Trp Lys Gln Leu Leu Asp Ser Gln Leu Ile Ser Gln 
                885                 890                 895     


Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asn 
            900                 905                 910         


Glu Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Arg Ile Leu Asp Thr Arg Phe Asn Thr Lys 
    930                 935                 940                 


Leu Asp Glu Ala Gly Asn Arg Ile Arg Asp Pro Lys Val Asn Ile Ile 
945                 950                 955                 960 


Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys Asp Tyr Gln Leu 
                965                 970                 975     


Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr 
            980                 985                 990         


Leu Asn Ala Val Val Ala Thr Ala  Leu Leu Lys Lys Tyr  Pro Gln Leu 
        995                 1000                 1005             


Ala Pro  Glu Phe Val Tyr Gly  Asp Tyr Pro Lys Tyr  Asn Ser Tyr 
    1010                 1015                 1020             


Lys Ser  Arg Lys Ser Ala Thr  Glu Lys Val Leu Phe  Tyr Ser Asn 
    1025                 1030                 1035             


Ile Met  Asn Phe Phe Arg Arg  Val Leu Val Tyr Ser  Lys Thr Gly 
    1040                 1045                 1050             


Glu Val  Arg Ile Arg Pro Val  Ile Glu Val Asn Lys  Glu Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Ser Asp Phe Arg Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Val Val Lys Lys  Val Glu Met 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Gln  His Gly Asp 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Glu Lys Phe  Tyr Leu Asp 
    1115                 1120                 1125             


Thr Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Ile  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Leu Ile Ala Asp Ile  Glu Lys Gly Lys Ala  Lys Lys Leu 
    1145                 1150                 1155             


Lys Arg  Val Lys Glu Leu Ile  Gly Ile Thr Ile Met  Glu Arg Met 
    1160                 1165                 1170             


Ala Phe  Glu Lys Asn Pro Ile  Glu Phe Leu Glu His  Lys Gly Tyr 
    1175                 1180                 1185             


Lys Asn  Ile Leu Glu Lys Asn  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Lys Glu  Leu Gln Lys Gly Asn  Glu Met Ile Leu Pro  Pro His Leu 
    1220                 1225                 1230             


Val Thr  Leu Leu Tyr His Ser  Ser Asn Ile His Lys  Ile Thr Glu 
    1235                 1240                 1245             


Pro Ile  His Leu Asn Tyr Val  Asn Lys Asn Lys His  Glu Phe Lys 
    1250                 1255                 1260             


Glu Leu  Leu Arg His Ile Ser  Asp Phe Ser Thr Arg  Tyr Ile Leu 
    1265                 1270                 1275             


Ala Gln  Asp Arg Leu Ser Lys  Ile Glu Glu Leu Tyr  Asp Lys Asn 
    1280                 1285                 1290             


Asp Gly  Asp Asp Ile Ser Asp  Leu Thr Ser Ser Phe  Val Asn Leu 
    1295                 1300                 1305             


Leu Thr  Phe Thr Ala Ile Gly  Ala Pro Ala Ala Phe  Lys Phe Leu 
    1310                 1315                 1320             


Gly Ser  Val Ile Asp Arg Lys  Arg Tyr Thr Ser Ile  Ala Glu Ile 
    1325                 1330                 1335             


Leu Glu  Ala Thr Leu Ile His  Gln Ser Val Thr Gly  Leu Tyr Glu 
    1340                 1345                 1350             


Thr Arg  Ile Asp Leu Ser Lys  Leu Gly Gly Asp 
    1355                 1360                 


<210>  231
<211>  1366
<212>  PRT
<213>  Streptococcus suis

<400>  231

Met Lys Lys Lys Tyr Ala Ile Gly Ile Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Phe Gly Asn Thr Glu Lys Arg Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Thr Leu Leu Phe Asp Glu Gly Asn Thr Ala Glu Asn Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Ile Asn Lys Ile Asp Asp Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Ile Val Glu Asp Lys Gln 
            100                 105                 110         


Gly Ser Lys His Pro Ile Phe Gly Thr Leu Gln Glu Glu Lys Glu Tyr 
        115                 120                 125             


His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala Asp 
    130                 135                 140                 


Ser Ser Gln Lys Ala Asp Ile Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly His Phe Leu Phe Glu Gly Asp Leu Lys Ser 
                165                 170                 175     


Glu Asn Lys Asp Val Gln His Leu Phe Asn Asp Phe Val Glu Met Phe 
            180                 185                 190         


Asp Lys Thr Val Glu Gly Ser Tyr Leu Ser Glu Asn Leu Pro Asn Val 
        195                 200                 205             


Ala Asp Val Leu Val Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Ile Leu His Tyr Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Phe Leu Thr Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Glu Leu Ala Glu Asp Ala Lys Ile Gln Phe Ser Lys Glu Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ile Ala Thr Lys Ser Leu Tyr Asp Gly Ile Leu Leu Ala Gly 
    290                 295                 300                 


Ile Leu Ser Thr Thr Asp Ser Thr Thr Lys Ala Pro Leu Ser Ser Ser 
305                 310                 315                 320 


Met Val Asn Arg Tyr Glu Glu His Gln Lys Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Asn Phe Ile His Gln Asn Leu Ser Asp Ser Tyr Lys Glu Val Phe Asn 
            340                 345                 350         


Asp Lys Leu Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr Thr 
        355                 360                 365             


Gln Glu Asn Phe Tyr Arg Phe Ile Lys Lys Ala Ile Glu Lys Ile Glu 
    370                 375                 380                 


Gly Ser Asn Tyr Phe Ile Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Val Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Glu Phe Ala Trp 
    450                 455                 460                 


Leu Asn Arg Lys Ser Asp Glu Lys Ile Arg Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Met Val Asp Lys Glu Thr Ser Ala Glu Asn Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Gln Tyr Leu Pro Asp Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Ala Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Tyr Val Thr Glu Gln Gly Lys Ser Phe Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Glu Lys Leu Met Asp Phe Leu Gly Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Leu Gly Leu Asp Lys Asp Asn Lys Ser Phe Asn Ala Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Val Ser Lys Asp Leu Leu 
        595                 600                 605             


Asp Asn Pro Glu Asn Glu Asp Ile Leu Glu Asn Val Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Lys Tyr 
625                 630                 635                 640 


Lys Asp Val Leu Thr Glu Glu Gln Arg Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asp Lys Val Thr Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Thr Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Thr Leu Ser 
    690                 695                 700                 


Phe Val Asp Glu Ile Arg Leu Ala Gln Gly Ser Gly Glu Ala Glu Asp 
705                 710                 715                 720 


Tyr Arg Ala Glu Val Gln Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Ile Glu Val Met 
            740                 745                 750         


Gly Tyr Asp Pro Glu His Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Tyr Lys Lys Ile 
    770                 775                 780                 


Glu Asn Ala Ile Lys Asn Leu Asp Ser Asn Leu Asn Ser Lys Ile Leu 
785                 790                 795                 800 


Lys Glu Tyr Pro Thr Asn Asn Gln Ala Leu Gln Asn Asp Arg Leu Phe 
                805                 810                 815     


Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Glu Glu Leu 
            820                 825                 830         


Asp Ile Asp Gln Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln 
        835                 840                 845             


Ala Phe Ile Lys Asp Asp Ser Leu Asp Asn Lys Val Leu Thr Lys Ser 
    850                 855                 860                 


Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile Val 
865                 870                 875                 880 


His Lys Lys Lys Asn Phe Trp Lys Gln Leu Leu Asp Ser Gln Leu Ile 
                885                 890                 895     


Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu 
            900                 905                 910         


Thr Asn Glu Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu Thr 
        915                 920                 925             


Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Thr Arg Phe Asn 
    930                 935                 940                 


Thr Lys Leu Asp Glu Ala Gly Asn Arg Ile Arg Asp Pro Lys Val Asn 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys Asp Tyr 
                965                 970                 975     


Gln Leu Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala His Asp 
            980                 985                 990         


Ala Tyr Leu Asn Ala Val Val Ala  Thr Ala Leu Leu Lys  Lys Tyr Pro 
        995                 1000                 1005             


Gln Leu  Ala Pro Glu Phe Val  Tyr Gly Asp Tyr Pro  Lys Tyr Asn 
    1010                 1015                 1020             


Ser Tyr  Lys Ser Arg Lys Ser  Ala Thr Glu Lys Val  Leu Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Arg Arg Val Leu Val  Tyr Ser Lys 
    1040                 1045                 1050             


Thr Gly  Glu Val Arg Ile Arg  Pro Val Ile Glu Val  Asn Lys Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Lys Ser Asp Phe  Arg Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Met  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Gln His 
    1100                 1105                 1110             


Gly Asp  Ser Asp Lys Leu Ile  Pro Arg Lys Thr Glu  Lys Phe Tyr 
    1115                 1120                 1125             


Leu Asp  Thr Lys Lys Tyr Gly  Gly Phe Asp Ser Pro  Thr Ile Ala 
    1130                 1135                 1140             


Tyr Ser  Val Leu Leu Ile Ala  Asp Ile Glu Lys Gly  Lys Ala Lys 
    1145                 1150                 1155             


Lys Leu  Lys Arg Val Lys Glu  Leu Ile Gly Ile Thr  Ile Met Glu 
    1160                 1165                 1170             


Arg Met  Ala Phe Glu Lys Asn  Pro Ile Glu Phe Leu  Glu His Lys 
    1175                 1180                 1185             


Gly Tyr  Lys Asn Ile Leu Glu  Lys Asn Ile Ile Lys  Leu Pro Lys 
    1190                 1195                 1200             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Arg Arg  Leu Leu Ala 
    1205                 1210                 1215             


Ser Ala  Lys Glu Leu Gln Lys  Gly Asn Glu Met Ile  Leu Pro Pro 
    1220                 1225                 1230             


His Leu  Val Thr Leu Leu Tyr  His Ser Ser Asn Ile  His Lys Ile 
    1235                 1240                 1245             


Thr Glu  Pro Ile His Leu Asn  Tyr Val Asn Lys Asn  Lys His Glu 
    1250                 1255                 1260             


Phe Lys  Glu Leu Leu Arg His  Ile Ser Asp Phe Ser  Thr Arg Tyr 
    1265                 1270                 1275             


Ile Leu  Ala Gln Asp Arg Leu  Ser Lys Ile Glu Glu  Leu Tyr Asp 
    1280                 1285                 1290             


Lys Asn  Asp Gly Asp Asp Ile  Ser Asp Leu Thr Ser  Ser Phe Val 
    1295                 1300                 1305             


Asn Leu  Leu Thr Phe Thr Ala  Ile Gly Ala Pro Ala  Ala Phe Lys 
    1310                 1315                 1320             


Phe Leu  Gly Ser Val Ile Asp  Arg Lys Arg Tyr Thr  Ser Ile Ala 
    1325                 1330                 1335             


Glu Ile  Leu Glu Ala Thr Leu  Ile His Gln Ser Val  Thr Gly Leu 
    1340                 1345                 1350             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu Gly Gly  Asp 
    1355                 1360                 1365     


<210>  232
<211>  1366
<212>  PRT
<213>  Streptococcus suis

<400>  232

Met Lys Lys Lys Tyr Ala Ile Gly Ile Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Phe Gly Asn Thr Glu Lys Arg Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Thr Leu Leu Phe Asp Glu Gly Asn Thr Ala Glu Asn Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Ile Asn Lys Ile Asp Asp Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Ile Val Glu Asp Lys Gln 
            100                 105                 110         


Gly Ser Lys His Pro Ile Phe Gly Thr Leu Gln Glu Glu Lys Glu Tyr 
        115                 120                 125             


His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala Asp 
    130                 135                 140                 


Ser Ser Gln Lys Ala Asp Ile Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly His Phe Leu Phe Glu Gly Asp Leu Lys Ser 
                165                 170                 175     


Glu Asn Lys Asp Val Gln His Leu Phe Asn Asp Phe Val Glu Met Phe 
            180                 185                 190         


Asp Lys Thr Val Glu Gly Ser Tyr Leu Ser Glu Asn Leu Pro Asn Val 
        195                 200                 205             


Ala Asp Val Leu Val Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Ile Leu His Tyr Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Phe Leu Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Glu Leu Ala Glu Asp Ala Lys Ile Gln Phe Ser Lys Glu Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ile Ala Thr Lys Ser Leu Tyr Asp Gly Ile Leu Leu Ala Gly 
    290                 295                 300                 


Ile Leu Ser Thr Thr Asp Ser Thr Thr Lys Ala Pro Leu Ser Ser Ser 
305                 310                 315                 320 


Met Val Asn Arg Tyr Glu Glu His Gln Lys Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Asn Phe Ile His Gln Asn Leu Ser Asp Ser Tyr Lys Glu Val Phe Asn 
            340                 345                 350         


Asp Lys Leu Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr Thr 
        355                 360                 365             


Gln Glu Asn Phe Tyr Arg Phe Ile Lys Lys Ala Ile Glu Lys Ile Glu 
    370                 375                 380                 


Gly Ser Asn Tyr Phe Ile Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Val Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Glu Phe Ala Trp 
    450                 455                 460                 


Leu Asn Arg Lys Ser Asp Glu Lys Ile Arg Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Met Val Asp Lys Glu Thr Ser Ala Glu Asn Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Gln Tyr Leu Pro Asp Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Ala Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Tyr Val Thr Glu Gln Gly Lys Ser Phe Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Glu Lys Leu Met Asp Phe Leu Gly Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Leu Gly Leu Asp Lys Asp Asn Lys Ser Phe Asn Ala Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Val Ser Lys Asp Leu Leu 
        595                 600                 605             


Asp Asn Pro Glu Asn Glu Asp Ile Leu Glu Asn Val Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Lys Tyr 
625                 630                 635                 640 


Lys Asp Val Leu Thr Glu Glu Gln Arg Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asp Lys Val Thr Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Thr Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Thr Leu Ser 
    690                 695                 700                 


Phe Val Asp Glu Ile Arg Leu Ala Gln Gly Ser Gly Glu Ala Glu Asp 
705                 710                 715                 720 


Tyr Arg Ala Glu Val Gln Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Ile Glu Val Met 
            740                 745                 750         


Gly Tyr Asp Pro Glu His Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Tyr Lys Lys Ile 
    770                 775                 780                 


Glu Asn Ala Ile Lys Asn Leu Asp Ser Asn Leu Asn Ser Lys Ile Leu 
785                 790                 795                 800 


Lys Glu Tyr Pro Thr Asn Asn Gln Ala Leu Gln Asn Asp Arg Leu Phe 
                805                 810                 815     


Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Glu Glu Leu 
            820                 825                 830         


Asp Ile Asp Gln Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln 
        835                 840                 845             


Ala Phe Ile Lys Asp Asp Ser Leu Asp Asn Lys Val Leu Thr Lys Ser 
    850                 855                 860                 


Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile Val 
865                 870                 875                 880 


His Lys Lys Lys Asn Phe Trp Lys Gln Leu Leu Asp Ser Gln Leu Ile 
                885                 890                 895     


Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu 
            900                 905                 910         


Thr Asn Glu Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu Thr 
        915                 920                 925             


Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Thr Arg Phe Asn 
    930                 935                 940                 


Thr Lys Leu Asp Glu Ala Gly Asn Arg Ile Arg Asp Pro Lys Val Asn 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys Asp Tyr 
                965                 970                 975     


Gln Leu Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala His Asp 
            980                 985                 990         


Ala Tyr Leu Asn Ala Val Val Ala  Thr Ala Leu Leu Lys  Lys Tyr Pro 
        995                 1000                 1005             


Gln Leu  Ala Pro Glu Phe Val  Tyr Gly Asp Tyr Pro  Lys Tyr Asn 
    1010                 1015                 1020             


Ser Tyr  Lys Ser Arg Lys Ser  Ala Thr Glu Lys Val  Leu Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Arg Arg Val Leu Val  Tyr Ser Lys 
    1040                 1045                 1050             


Thr Gly  Glu Val Arg Ile Arg  Pro Val Ile Glu Val  Asn Lys Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Lys Ser Asp Phe  Arg Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Met  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Gln His 
    1100                 1105                 1110             


Gly Asp  Ser Asp Lys Leu Ile  Pro Arg Lys Thr Glu  Lys Phe Tyr 
    1115                 1120                 1125             


Leu Asp  Thr Lys Lys Tyr Gly  Gly Phe Asp Ser Pro  Thr Ile Ala 
    1130                 1135                 1140             


Tyr Ser  Val Leu Leu Ile Ala  Asp Ile Glu Lys Gly  Lys Ala Lys 
    1145                 1150                 1155             


Lys Leu  Lys Arg Val Lys Glu  Leu Ile Gly Ile Thr  Ile Met Glu 
    1160                 1165                 1170             


Arg Met  Ala Phe Glu Lys Asn  Pro Ile Glu Phe Leu  Glu His Lys 
    1175                 1180                 1185             


Gly Tyr  Lys Asn Ile Leu Glu  Lys Asn Ile Ile Lys  Leu Pro Lys 
    1190                 1195                 1200             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Arg Arg  Leu Leu Ala 
    1205                 1210                 1215             


Ser Ala  Lys Glu Leu Gln Lys  Gly Asn Glu Met Ile  Leu Pro Pro 
    1220                 1225                 1230             


His Leu  Val Thr Leu Leu Tyr  His Ser Ser Asn Ile  His Lys Ile 
    1235                 1240                 1245             


Thr Glu  Pro Ile His Leu Asn  Tyr Val Asn Lys Asn  Lys His Glu 
    1250                 1255                 1260             


Phe Lys  Glu Leu Leu Arg His  Ile Ser Asp Phe Ser  Thr Arg Tyr 
    1265                 1270                 1275             


Ile Leu  Ala Gln Asp Arg Leu  Ser Lys Ile Glu Glu  Leu Tyr Asp 
    1280                 1285                 1290             


Lys Asn  Asp Gly Asp Asp Ile  Ser Asp Leu Thr Ser  Ser Phe Val 
    1295                 1300                 1305             


Asn Leu  Leu Thr Phe Thr Ala  Ile Gly Ala Pro Ala  Ala Phe Lys 
    1310                 1315                 1320             


Phe Leu  Gly Ser Val Ile Asp  Arg Lys Arg Tyr Thr  Ser Ile Ala 
    1325                 1330                 1335             


Glu Ile  Leu Glu Ala Thr Leu  Ile His Gln Ser Val  Thr Gly Leu 
    1340                 1345                 1350             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu Gly Gly  Asp 
    1355                 1360                 1365     


<210>  233
<211>  1364
<212>  PRT
<213>  Streptococcus suis

<400>  233

Met Lys Lys Lys Tyr Ala Ile Gly Ile Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Phe Gly Asn Thr Glu Lys Arg Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Thr Leu Leu Phe Asp Glu Gly Asn Thr Ala Glu Asn Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Ile Asn Lys Ile Asp Asp Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Ile Val Glu Asp Lys Gln 
            100                 105                 110         


Gly Ser Lys His Pro Ile Phe Gly Thr Leu Gln Glu Glu Lys Lys Tyr 
        115                 120                 125             


His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala Asp 
    130                 135                 140                 


Ser Ser Gln Lys Ala Asp Ile Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly His Phe Leu Phe Glu Gly Asp Leu Lys Ser 
                165                 170                 175     


Glu Asn Lys Asp Val Gln His Leu Phe Asn Asp Phe Val Glu Met Phe 
            180                 185                 190         


Asp Lys Thr Val Glu Gly Ser Tyr Leu Ser Glu Asn Leu Pro Asn Val 
        195                 200                 205             


Ala Asp Val Leu Val Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Ile Leu His Tyr Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Phe Leu Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Glu Leu Ala Glu Asp Ala Lys Ile Gln Phe Ser Lys Glu Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ile Ala Thr Lys Ser Leu Tyr Asp Gly Ile Leu Leu Ala Gly 
    290                 295                 300                 


Ile Leu Ser Thr Thr Asp Ser Thr Thr Lys Ala Pro Leu Ser Ser Ser 
305                 310                 315                 320 


Met Val Asn Arg Tyr Glu Glu His Lys Lys Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Asn Phe Ile His Gln Asn Leu Ser Asp Ser Tyr Lys Glu Val Phe Asn 
            340                 345                 350         


Asp Lys Leu Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr Thr 
        355                 360                 365             


Gln Glu Asn Phe Tyr Arg Phe Ile Lys Lys Ala Ile Glu Lys Ile Glu 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Ile Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Val Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Glu Phe Ala Trp 
    450                 455                 460                 


Leu Asn Arg Lys Ser Asp Glu Lys Ile Arg Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Met Val Asp Lys Glu Thr Ser Ala Glu Asn Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Gln Tyr Leu Pro Asp Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Ala Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Phe Ile Ala Glu Gly Met Arg Asp Tyr Gln Phe Leu Asp Ser Gly Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Lys Thr Leu Phe Lys Thr Lys Arg Lys Val Thr 
545                 550                 555                 560 


Ala Lys Asp Ile Lys Ala Tyr Leu Glu Asn Ser Asn Gly Tyr Ala Gly 
                565                 570                 575     


Val Glu Leu Lys Gly Leu Glu Glu Gln Phe Asn Ala Ser Leu Pro Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Leu Arg Asp Lys Ala Phe Ile Asp Ala 
        595                 600                 605             


Glu Glu Asn Gln Glu Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Lys Tyr Lys Asp 
625                 630                 635                 640 


Ile Leu Thr Glu Glu Gln Arg Lys Lys Leu Glu Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Leu Asp Lys 
            660                 665                 670         


Val Thr Arg Lys Thr Ile Leu Gly Tyr Leu Ile Asp Asp Gly Thr Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Thr Leu Ser Phe Val 
    690                 695                 700                 


Asp Glu Ile Arg Leu Ala Gln Gly Ser Gly Glu Ala Glu Asp Tyr Arg 
705                 710                 715                 720 


Ala Glu Val Gln Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Ile Glu Val Met Gly Tyr 
            740                 745                 750         


Asp Pro Glu His Ile Val Val Glu Met Ala Arg Glu Asn Gln Phe Thr 
        755                 760                 765             


Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Tyr Lys Lys Ile Glu Asn 
    770                 775                 780                 


Ala Ile Lys Asn Leu Asp Ser Asn Leu Asn Ser Lys Ile Leu Lys Glu 
785                 790                 795                 800 


Tyr Pro Thr Asn Asn Gln Ala Leu Gln Asn Asp Arg Leu Phe Leu Tyr 
                805                 810                 815     


Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Glu Glu Leu Asp Ile 
            820                 825                 830         


Asp Gln Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe 
        835                 840                 845             


Ile Lys Asp Asp Ser Leu Asp Asn Lys Val Leu Thr Lys Ser Ala Lys 
    850                 855                 860                 


Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile Val His Lys 
865                 870                 875                 880 


Lys Lys Asn Phe Trp Lys Gln Leu Leu Asp Ser Gln Leu Ile Ser Gln 
                885                 890                 895     


Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asn 
            900                 905                 910         


Glu Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Arg Ile Leu Asp Thr Arg Phe Asn Thr Lys 
    930                 935                 940                 


Leu Asp Glu Ala Gly Asn Arg Ile Arg Asp Pro Lys Val Asn Ile Ile 
945                 950                 955                 960 


Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys Asp Tyr Gln Leu 
                965                 970                 975     


Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr 
            980                 985                 990         


Leu Asn Ala Val Val Ala Thr Ala  Leu Leu Lys Lys Tyr  Pro Gln Leu 
        995                 1000                 1005             


Ala Pro  Glu Phe Val Tyr Gly  Asp Tyr Pro Lys Tyr  Asn Ser Tyr 
    1010                 1015                 1020             


Lys Ser  Arg Lys Ser Ala Thr  Glu Lys Val Leu Phe  Tyr Ser Asn 
    1025                 1030                 1035             


Ile Met  Asn Phe Phe Arg Arg  Val Leu Val Tyr Ser  Lys Thr Gly 
    1040                 1045                 1050             


Glu Val  Arg Ile Arg Pro Val  Ile Glu Val Asn Lys  Glu Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Ser Asp Phe Lys Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Val Val Lys Lys  Val Glu Met 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Gln  His Gly Asp 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Glu Lys Phe  Tyr Leu Asp 
    1115                 1120                 1125             


Thr Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Ile  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Leu Ile Ala Asp Ile  Glu Lys Gly Lys Ala  Lys Lys Leu 
    1145                 1150                 1155             


Lys Arg  Val Lys Glu Leu Ile  Gly Ile Thr Ile Met  Glu Arg Met 
    1160                 1165                 1170             


Ala Phe  Glu Lys Asn Pro Ile  Glu Phe Leu Glu His  Lys Gly Tyr 
    1175                 1180                 1185             


Lys Asn  Ile Leu Glu Lys Asn  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Lys Glu  Leu Gln Lys Gly Asn  Glu Met Ile Leu Pro  Pro His Leu 
    1220                 1225                 1230             


Val Thr  Leu Leu Tyr His Ser  Ser Asn Ile His Lys  Ile Thr Glu 
    1235                 1240                 1245             


Pro Ile  His Leu Asn Tyr Val  Asn Lys Asn Lys His  Glu Phe Lys 
    1250                 1255                 1260             


Glu Leu  Leu Arg His Ile Ser  Asp Phe Ser Thr Arg  Tyr Ile Leu 
    1265                 1270                 1275             


Ala Gln  Asp Arg Leu Ser Lys  Ile Glu Glu Leu Tyr  Asp Lys Asn 
    1280                 1285                 1290             


Asp Gly  Asp Asp Ile Ser Asp  Leu Thr Ser Ser Phe  Val Asn Leu 
    1295                 1300                 1305             


Leu Thr  Phe Thr Ala Ile Gly  Ala Pro Ala Ala Phe  Lys Phe Leu 
    1310                 1315                 1320             


Gly Ser  Val Ile Asp Arg Lys  Arg Tyr Thr Ser Ile  Ala Glu Ile 
    1325                 1330                 1335             


Leu Glu  Ala Thr Leu Ile His  Gln Ser Val Thr Gly  Leu Tyr Glu 
    1340                 1345                 1350             


Thr Arg  Ile Asp Leu Ser Lys  Leu Gly Gly Asp 
    1355                 1360                 


<210>  234
<211>  1386
<212>  PRT
<213>  Streptococcus suis

<400>  234

Met Asp Gln Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Asn Lys Val Asp Glu Asn 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Asp Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Ile Ala Ala Glu Val Lys Tyr 
        115                 120                 125             


His Asp Asp Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ile Ser Gln Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asn Val Gln Ala Leu Phe Lys Asp Phe Val Glu Val Tyr 
            180                 185                 190         


Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Met Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala His Tyr Pro Ala Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Leu Leu Gly Glu Ile Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Leu Lys 
                325                 330                 335     


Asp Phe Ile Lys Val Asn Ala Pro Asp Gln Tyr Asn Ala Ile Phe Lys 
            340                 345                 350         


Asp Lys Asn Lys Lys Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Gln Ile Asn 
    370                 375                 380                 


Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Glu Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp 
465                 470                 475                 480 


Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Leu Asn Tyr Leu Gly Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ser Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asn Lys Glu Asn Glu Gln Ile Ile Glu Asp Ile Ile Gln Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Lys Ala Gln Leu Lys Lys Leu Glu Arg Cys His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asp 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Tyr Asn Pro Ala Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Asp Lys Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Asn Leu Asp Asn Pro Val Asn Ile Lys Asn Val 
785                 790                 795                 800 


Glu Asn Gln Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu 
            820                 825                 830         


Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Phe Asp Asn Arg Val Leu Thr Ser Ser Ser Glu Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Ile Glu Val Val Arg Ala Arg Lys Ala 
865                 870                 875                 880 


Asp Trp Met Arg Leu Arg Lys Ala Gly Leu Ile Ser Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Asn Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Val Leu Asp Ala Arg Phe Asn Ala Lys His Asp Glu 
    930                 935                 940                 


Asn Lys Lys Val Ile Arg Asp Val Lys Ile Ile Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Gln Phe Arg Lys Asp Phe Lys Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Ile 
            980                 985                 990         


Gly Thr Ala Leu Leu Lys Lys Tyr  Pro Lys Leu Ala Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Glu Phe Lys Lys Tyr  Asp Val Arg Lys Phe  Ile Ala Lys 
    1010                 1015                 1020             


Ser Asp  Lys Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Leu Met Asn Phe Phe  Lys Lys Glu Val Lys  Phe Ala Asp 
    1040                 1045                 1050             


Gly Thr  Val Val Glu Arg Pro  Asp Ile Glu Thr Ser  Glu Asp Gly 
    1055                 1060                 1065             


Glu Ile  Ala Trp Asn Lys Gln  Thr Asp Phe Lys Ile  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1085                 1090                 1095             


Gln Thr  His Gly Leu Asp Arg  Gly Lys Pro Arg Gly  Leu Phe Asn 
    1100                 1105                 1110             


Ala Asn  Pro Ser Pro Lys Pro  Lys Pro Asp Ser Ser  Glu Asn Leu 
    1115                 1120                 1125             


Val Gly  Val Lys Arg Asn Leu  Asp Pro Lys Lys Tyr  Gly Gly Tyr 
    1130                 1135                 1140             


Ala Gly  Ile Ser Asn Ser Tyr  Ala Val Leu Val Lys  Ala Ile Ile 
    1145                 1150                 1155             


Glu Lys  Gly Val Lys Lys Lys  Glu Thr Met Val Leu  Glu Phe Gln 
    1160                 1165                 1170             


Gly Ile  Ser Ile Leu Asp Arg  Ile Thr Phe Glu Lys  Asp Lys Arg 
    1175                 1180                 1185             


Ala Phe  Leu Leu Gly Lys Gly  Tyr Lys Asp Ile Lys  Lys Ile Ile 
    1190                 1195                 1200             


Glu Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Lys Asp  Gly Ser Arg 
    1205                 1210                 1215             


Arg Met  Leu Ala Ser Ile Leu  Ser Thr Asn Asn Lys  Arg Gly Glu 
    1220                 1225                 1230             


Ile His  Lys Gly Asn Glu Leu  Phe Val Pro Gln Lys  Phe Thr Thr 
    1235                 1240                 1245             


Leu Leu  Tyr His Ala Lys Arg  Ile Asn Asn Pro Ile  Asn Lys Asp 
    1250                 1255                 1260             


His Ile  Glu Tyr Val Lys Lys  His Arg Asp Asp Phe  Lys Glu Leu 
    1265                 1270                 1275             


Leu Asn  Tyr Val Leu Glu Phe  Asn Glu Lys Tyr Val  Gly Ala Thr 
    1280                 1285                 1290             


Lys Asn  Gly Glu Arg Leu Lys  Glu Ala Val Ala Asp  Phe Asp Ser 
    1295                 1300                 1305             


Lys Ser  Asn Glu Glu Ile Cys  Thr Ser Phe Leu Gly  Ala Val Asn 
    1310                 1315                 1320             


Ser Lys  Asn Ala Gly Leu Phe  Glu Leu Thr Ser Leu  Gly Ser Ala 
    1325                 1330                 1335             


Ser Asp  Phe Glu Phe Leu Gly  Val Lys Ile Pro Arg  Tyr Arg Asp 
    1340                 1345                 1350             


Tyr Thr  Pro Ser Ser Leu Leu  Lys Asp Ser Thr Leu  Ile His Gln 
    1355                 1360                 1365             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1370                 1375                 1380             


Gly Glu  Asp 
    1385     


<210>  235
<211>  1300
<212>  PRT
<213>  Brochothrix thermosphacta

<400>  235

Met Trp Gly Val Ser Leu Phe Glu Ala Gly Lys Thr Ala Ala Glu Arg 
1               5                   10                  15      


Arg Gly Tyr Arg Ser Thr Arg Arg Arg Leu Asn His Arg Lys Phe Arg 
            20                  25                  30          


Leu Arg Leu Leu Glu Asp Met Phe Glu Lys Glu Ile Leu Ser Lys Asp 
        35                  40                  45              


Pro Ser Phe Phe Ile Arg Leu Lys Glu Ala Phe Leu Ser Pro Lys Asp 
    50                  55                  60                  


Glu Gln Lys Gln Phe Lys Gly Asn Ile Leu Phe Asn Asp Lys Asp Tyr 
65                  70                  75                  80  


Thr Asp Ala Asp Tyr Tyr Glu Gln Tyr Lys Thr Ile Tyr His Leu Arg 
                85                  90                  95      


Tyr Asp Leu Ile Ser Gln His Arg Gln Phe Asp Ile Arg Glu Val Tyr 
            100                 105                 110         


Leu Ala Ile His His Leu Ile Lys Tyr Arg Gly His Phe Ile Tyr Glu 
        115                 120                 125             


Asp Gln Thr Phe Thr Thr Asp Gly Asn Gln Leu Gln His His Ile Lys 
    130                 135                 140                 


Ala Ile Ile Thr Met Ile Asn Ser Thr Leu Asn Arg Ile Ile Ile Pro 
145                 150                 155                 160 


Glu Thr Ile Asp Ile Asn Val Phe Glu Lys Ile Leu Leu Asp Arg Met 
                165                 170                 175     


Met Asn Arg Ser Ser Lys Val Lys Phe Leu Ile Glu Leu Thr Gly Glu 
            180                 185                 190         


Asp Lys Gln Asp Lys Pro Leu Leu Lys Glu Leu Phe Asn Leu Ile Val 
        195                 200                 205             


Gly Leu Lys Ala Lys Pro Ala Ser Ile Phe Glu Gln Glu Asn Leu Ala 
    210                 215                 220                 


Thr Ile Val Glu Thr Met Asn Met Ser Thr Glu Gln Val Gln Leu Asp 
225                 230                 235                 240 


Leu Leu Thr Leu Ala Asp Val Leu Ala Asp Glu Glu Tyr Asp Leu Leu 
                245                 250                 255     


Leu Thr Ala Gln Lys Ile Tyr Ser Ala Ile Ile Leu Asp Glu Ser Met 
            260                 265                 270         


Asp Gly Tyr Glu Tyr Phe Ala Glu Ala Lys Lys Glu Ser Tyr Arg Lys 
        275                 280                 285             


His Gln Glu Glu Leu Val Leu Val Lys Lys Met Leu Lys Ser Asn Ala 
    290                 295                 300                 


Ile Thr Asn Asp Glu Arg Ala Lys Phe Glu Tyr Phe Tyr Thr Asp Tyr 
305                 310                 315                 320 


Ile Gly Ala Lys Ser Ser Asn Tyr Glu Glu Ser Lys Asn Ile Lys Lys 
                325                 330                 335     


Gly Leu Ser Ala Ala Tyr Gly Lys Tyr Ser Lys Glu Glu Arg Leu Phe 
            340                 345                 350         


Lys His Ile Glu Leu Leu Leu Ala Lys Glu Asn Val Leu Thr Thr Val 
        355                 360                 365             


Glu His Ala Leu Leu Glu Lys Asn Ile Thr Phe Ala Ser Leu Leu Pro 
    370                 375                 380                 


Leu Gln Arg Ser Ser Arg Asn Ala Val Ile Pro Tyr Gln Val His Glu 
385                 390                 395                 400 


Lys Glu Leu Val Ala Ile Leu Glu Asn Gln Ala Thr Tyr Tyr Pro Phe 
                405                 410                 415     


Leu Leu Glu Gln Lys Asp Asn Ile His Lys Leu Leu Thr Phe Arg Ile 
            420                 425                 430         


Pro Tyr Tyr Val Gly Pro Leu Ala Asp Gln Lys Asp Ser Glu Phe Ala 
        435                 440                 445             


Trp Met Val Arg Lys Gln Ala Gly Lys Ile Thr Pro Phe Asn Phe Glu 
    450                 455                 460                 


Glu Met Val Asp Ile Asp Ala Ser Ser Glu Ala Phe Ile Lys Arg Met 
465                 470                 475                 480 


Thr Asn Lys Cys Thr Tyr Leu Ile His Glu Asp Val Ile Pro Lys His 
                485                 490                 495     


Ser Phe Ser Tyr Ala Lys Phe Glu Val Leu Asn Glu Leu Asn Lys Ile 
            500                 505                 510         


Arg Leu Asp Gly Lys Pro Ile Asp Ile Pro Leu Lys Lys Arg Ile Phe 
        515                 520                 525             


Glu Gly Leu Phe Leu Glu Lys Thr Lys Val Thr Gln Thr Ser Leu Lys 
    530                 535                 540                 


Lys Trp Leu Ala Glu His Glu His Met Thr Val Ser Val Val Gln Gly 
545                 550                 555                 560 


Thr Gln Lys Glu Thr Glu Phe Ala Thr Ser Leu Gln Ala Phe His Arg 
                565                 570                 575     


Phe Val Lys Ile Phe Asp Arg Glu Thr Val Ser Asn Pro Ala Asn Glu 
            580                 585                 590         


Glu Met Phe Glu Lys Ile Ile Tyr Trp Ser Thr Val Phe Glu Asp Lys 
        595                 600                 605             


Lys Ile Met Arg Arg Lys Leu Ser Glu Tyr Pro Gln Leu Thr Glu Gln 
    610                 615                 620                 


Gln Gln Val Gln Leu Ala Gln Val Arg Phe Arg Gly Trp Gly Arg Leu 
625                 630                 635                 640 


Ser Gln Arg Leu Ile Asn Arg Ile Lys Thr Pro Val Ser Gly Asp Glu 
                645                 650                 655     


Asp His Lys Leu Ser Ile Asn Glu Ile Leu Trp Gln Thr Asn Glu Asn 
            660                 665                 670         


Phe Met Gln Ile Ile Arg Asn Lys Asp Tyr Leu Phe Lys Lys Ile Ile 
        675                 680                 685             


Glu Glu Gln Phe Glu Asn Glu Thr Ala Leu Leu Asn Lys Gln Arg Ile 
    690                 695                 700                 


Asp Glu Leu Ala Ala Ser Pro Ala Asn Lys Lys Gly Ile Trp Gln Ala 
705                 710                 715                 720 


Ile Lys Ile Val Lys Glu Leu Glu Lys Val Leu Gln Gln Pro Ala Glu 
                725                 730                 735     


Asn Ile Phe Ile Glu Phe Ala Arg Ser Asp Glu Glu Ser Lys Arg Ser 
            740                 745                 750         


Thr Pro Arg Asp Lys Phe Ile Glu Lys Ala Tyr Ala Gln Leu Lys Lys 
        755                 760                 765             


Glu Thr Asp Thr Phe Asn Leu Glu His Leu Lys Glu Leu Lys Gln Arg 
    770                 775                 780                 


Ser Lys Gln Leu Ser Ser Gln Arg Leu Phe Leu Tyr Phe Ile Gln Asn 
785                 790                 795                 800 


Gly Lys Cys Met Tyr Ser Gly Glu His Leu Asp Ile Glu Arg Leu Asp 
                805                 810                 815     


Ser Tyr Glu Val Asp His Ile Leu Pro Gln Ser Tyr Ile Lys Asp Asn 
            820                 825                 830         


Ser Ile Glu Asn Leu Ala Leu Val Lys Lys Val Glu Asn Gln Arg Lys 
        835                 840                 845             


Lys Asp Ser Leu Leu Leu Asn Ser Ser Ile Ile Asn Gln Asn Tyr Ser 
    850                 855                 860                 


Arg Trp Glu Gln Leu Lys Asn Ala Gly Leu Ile Gly Glu Lys Lys Phe 
865                 870                 875                 880 


Arg Asn Leu Thr Arg Thr Lys Ile Thr Asp Arg Asp Lys Glu Gly Phe 
                885                 890                 895     


Ile Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Thr 
            900                 905                 910         


Gln Leu Leu Gln Gln Glu Tyr Lys Asp Thr Thr Lys Val Phe Ala Ile 
        915                 920                 925             


Lys Ala Thr Leu Val Ser Gly Leu Arg Arg Lys Phe Glu Phe Ile Lys 
    930                 935                 940                 


Asn Arg Asn Val Asn Asp Tyr His His Ala Gln Asp Ala Phe Leu Val 
945                 950                 955                 960 


Ala Phe Leu Gly Thr Asn Ile Thr Ser Asn Tyr Pro Lys Ile Glu Met 
                965                 970                 975     


Glu Tyr Leu Phe Lys Gly Tyr Gln His Tyr Leu Asn Glu Val Gly Lys 
            980                 985                 990         


Ser Ala Ala Lys Pro Lys Phe Thr  Phe Ile Val Glu Asn  Leu Ser Lys 
        995                 1000                 1005             


Gln Gln  Tyr Asn Ser Thr Thr  Gly Glu Val Lys Trp  Asn Pro Glu 
    1010                 1015                 1020             


Val Asp  Ile Ala Lys Leu Lys  Arg Ile Leu Asn Phe  Lys Gln Cys 
    1025                 1030                 1035             


Asn Ile  Val Arg Lys Val Glu  Glu Gln Ser Gly Ala  Leu Phe Lys 
    1040                 1045                 1050             


Glu Thr  Ile Tyr Pro Val Glu  Glu Ser Ser Ser Lys  Thr Ile Pro 
    1055                 1060                 1065             


Leu Lys  Lys His Leu Asp Thr  Ala Ile Tyr Gly Gly  Tyr Thr Ala 
    1070                 1075                 1080             


Val Asn  Tyr Ala Ser Tyr Ala  Leu Ile Gln Phe Lys  Lys Gly Arg 
    1085                 1090                 1095             


Lys Leu  Lys Arg Glu Ile Ile  Gly Ile Pro Leu Ala  Val Gln Thr 
    1100                 1105                 1110             


Arg Ile  Asp Asn Ser Glu Thr  Ser Leu Gln Ala Tyr  Ile Ala Glu 
    1115                 1120                 1125             


Gln Ile  Lys Ser Glu Val Glu  Ile Leu Asn Gly Arg  Ile Leu Lys 
    1130                 1135                 1140             


Tyr Gln  Leu Ile Ser Asn Asn  Gly Asn Arg Leu Tyr  Ile Ala Gly 
    1145                 1150                 1155             


Pro Ser  Glu Arg His Asn Ala  Arg Gln Leu Ile Val  Ser Asp Glu 
    1160                 1165                 1170             


Ala Ala  Lys Val Ile Trp Leu  Ile Ser Thr Lys Gln  Ala Asp Glu 
    1175                 1180                 1185             


Ala Met  Phe Leu Lys Tyr Tyr  Arg Leu Glu His Leu  Glu Ala Val 
    1190                 1195                 1200             


Phe Glu  Glu Leu Ile Arg Lys  Gln Ala Ala Asp Tyr  Gln Ile Phe 
    1205                 1210                 1215             


Glu Lys  Leu Ile Lys Lys Ile  Glu Val Asn Lys Val  Tyr Phe Tyr 
    1220                 1225                 1230             


Ser Cys  Thr Tyr Asn Glu Lys  Val Lys Val Ile Glu  Glu Leu Leu 
    1235                 1240                 1245             


Lys Ile  Thr Gln Ala Asn Ala  Thr Asn Gly Asp Leu  Lys Leu Leu 
    1250                 1255                 1260             


Lys Met  Ser Asn Arg Glu Gly  Arg Leu Gly Ser Val  Ser Val Ala 
    1265                 1270                 1275             


Leu Asp  Phe Lys Ile Ile Asn  Gln Ser Val Thr Gly  Leu Tyr Gln 
    1280                 1285                 1290             


Ser Ile  Glu Asp Tyr Asn Asn  
    1295                 1300 


<210>  236
<211>  1329
<212>  PRT
<213>  Catenibacterium mitsuokai

<400>  236

Ile Val Asp Tyr Cys Ile Gly Leu Asp Leu Gly Thr Gly Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Val Asp Met Asn His Arg Leu Met Lys Arg Asn Gly Lys 
            20                  25                  30          


His Leu Trp Gly Ser Arg Leu Phe Ser Asn Ala Glu Thr Ala Ala Asn 
        35                  40                  45              


Arg Arg Ala Ser Arg Ser Ile Arg Arg Arg Tyr Asn Lys Arg Arg Glu 
    50                  55                  60                  


Arg Ile Arg Leu Leu Arg Ala Ile Leu Gln Asp Met Val Leu Glu Lys 
65                  70                  75                  80  


Asp Pro Thr Phe Phe Ile Arg Leu Glu His Thr Ser Phe Leu Asp Glu 
                85                  90                  95      


Glu Asp Lys Ala Lys Tyr Leu Gly Thr Asp Tyr Lys Asp Asn Tyr Asn 
            100                 105                 110         


Leu Phe Ile Asp Glu Asp Phe Asn Asp Tyr Thr Tyr Tyr His Lys Tyr 
        115                 120                 125             


Pro Thr Ile Tyr His Leu Arg Lys Ala Leu Cys Glu Ser Thr Glu Lys 
    130                 135                 140                 


Ala Asp Pro Arg Leu Ile Tyr Leu Ala Leu His His Ile Val Lys Tyr 
145                 150                 155                 160 


Arg Gly Asn Phe Leu Tyr Glu Gly Gln Lys Phe Asn Met Asp Ala Ser 
                165                 170                 175     


Asn Ile Glu Asp Lys Leu Ser Asp Ile Phe Thr Gln Phe Thr Ser Phe 
            180                 185                 190         


Asn Asn Ile Pro Tyr Glu Asp Asp Glu Lys Lys Asn Leu Glu Ile Leu 
        195                 200                 205             


Glu Ile Leu Lys Lys Pro Leu Ser Lys Lys Ala Lys Val Asp Glu Val 
    210                 215                 220                 


Met Thr Leu Ile Ala Pro Glu Lys Asp Tyr Lys Ser Ala Phe Lys Glu 
225                 230                 235                 240 


Leu Val Thr Gly Ile Ala Gly Asn Lys Met Asn Val Thr Lys Met Ile 
                245                 250                 255     


Leu Cys Glu Pro Ile Lys Gln Gly Asp Ser Glu Ile Lys Leu Lys Phe 
            260                 265                 270         


Ser Asp Ser Asn Tyr Asp Asp Gln Phe Ser Glu Val Glu Lys Asp Leu 
        275                 280                 285             


Gly Glu Tyr Val Glu Phe Val Asp Ala Leu His Asn Val Tyr Ser Trp 
    290                 295                 300                 


Val Glu Leu Gln Thr Ile Met Gly Ala Thr His Thr Asp Asn Ala Ser 
305                 310                 315                 320 


Ile Ser Glu Ala Met Val Ser Arg Tyr Asn Lys His His Asp Asp Leu 
                325                 330                 335     


Lys Leu Leu Lys Asp Cys Ile Lys Asn Asn Val Pro Asn Lys Tyr Phe 
            340                 345                 350         


Asp Met Phe Arg Asn Asp Ser Glu Lys Ser Lys Gly Tyr Tyr Asn Tyr 
        355                 360                 365             


Ile Asn Arg Pro Ser Lys Ala Pro Val Asp Glu Phe Tyr Lys Tyr Val 
    370                 375                 380                 


Lys Lys Cys Ile Glu Lys Val Asp Thr Pro Glu Ala Lys Gln Ile Leu 
385                 390                 395                 400 


Asn Asp Ile Glu Leu Glu Asn Phe Leu Leu Lys Gln Asn Ser Arg Thr 
                405                 410                 415     


Asn Gly Ser Val Pro Tyr Gln Met Gln Leu Asp Glu Met Ile Lys Ile 
            420                 425                 430         


Ile Asp Asn Gln Ala Glu Tyr Tyr Pro Ile Leu Lys Glu Lys Arg Glu 
        435                 440                 445             


Gln Leu Leu Ser Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Phe Gly Pro 
    450                 455                 460                 


Leu Asn Glu Thr Ser Glu His Ala Trp Ile Lys Arg Leu Glu Gly Lys 
465                 470                 475                 480 


Glu Asn Gln Arg Ile Leu Pro Trp Asn Tyr Gln Asp Ile Val Asp Val 
                485                 490                 495     


Asp Ala Thr Ala Glu Gly Phe Ile Lys Arg Met Arg Ser Tyr Cys Thr 
            500                 505                 510         


Tyr Phe Pro Asp Glu Glu Val Leu Pro Lys Asn Ser Leu Ile Val Ser 
        515                 520                 525             


Lys Tyr Glu Val Tyr Asn Glu Leu Asn Lys Ile Arg Val Asp Asp Lys 
    530                 535                 540                 


Leu Leu Glu Val Asp Val Lys Asn Asp Ile Tyr Asn Glu Leu Phe Met 
545                 550                 555                 560 


Lys Asn Lys Thr Val Thr Glu Lys Lys Leu Lys Asn Trp Leu Val Asn 
                565                 570                 575     


Asn Gln Cys Cys Ser Lys Asp Ala Glu Ile Lys Gly Phe Gln Lys Glu 
            580                 585                 590         


Asn Gln Phe Ser Thr Ser Leu Thr Pro Trp Ile Asp Phe Thr Asn Ile 
        595                 600                 605             


Phe Gly Lys Ile Asp Gln Ser Asn Phe Asp Leu Ile Glu Asn Ile Ile 
    610                 615                 620                 


Tyr Asp Leu Thr Val Phe Glu Asp Lys Lys Ile Met Lys Arg Arg Leu 
625                 630                 635                 640 


Lys Lys Lys Tyr Ala Leu Pro Asp Asp Lys Val Lys Gln Ile Leu Lys 
                645                 650                 655     


Leu Lys Tyr Lys Asp Trp Ser Arg Leu Ser Lys Lys Leu Leu Asp Gly 
            660                 665                 670         


Ile Val Ala Asp Asn Arg Phe Gly Ser Ser Val Thr Val Leu Asp Val 
        675                 680                 685             


Leu Glu Met Ser Arg Leu Asn Leu Met Glu Ile Ile Asn Asp Lys Asp 
    690                 695                 700                 


Leu Gly Tyr Ala Gln Met Ile Glu Glu Ala Thr Ser Cys Pro Glu Asp 
705                 710                 715                 720 


Gly Lys Phe Thr Tyr Glu Glu Val Glu Arg Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Leu Lys Arg Gly Ile Trp Gln Ser Leu Gln Ile Val Glu Glu Ile Thr 
            740                 745                 750         


Lys Val Met Lys Cys Arg Pro Lys Tyr Ile Tyr Ile Glu Phe Glu Arg 
        755                 760                 765             


Ser Glu Glu Ala Lys Glu Arg Thr Glu Ser Lys Ile Lys Lys Leu Glu 
    770                 775                 780                 


Asn Val Tyr Lys Asp Leu Asp Glu Gln Thr Lys Lys Glu Tyr Lys Ser 
785                 790                 795                 800 


Val Leu Glu Glu Leu Lys Gly Phe Asp Asn Thr Lys Lys Ile Ser Ser 
                805                 810                 815     


Asp Ser Leu Phe Leu Tyr Phe Thr Gln Leu Gly Lys Cys Met Tyr Ser 
            820                 825                 830         


Gly Lys Lys Leu Asp Ile Asp Ser Leu Asp Lys Tyr Gln Ile Asp His 
        835                 840                 845             


Ile Val Pro Gln Ser Leu Val Lys Asp Asp Ser Phe Asp Asn Arg Val 
    850                 855                 860                 


Leu Val Val Pro Ser Glu Asn Gln Arg Lys Leu Asp Asp Leu Val Val 
865                 870                 875                 880 


Pro Phe Asp Ile Arg Asp Lys Met Tyr Arg Phe Trp Lys Leu Leu Phe 
                885                 890                 895     


Asp His Glu Leu Ile Ser Pro Lys Lys Phe Tyr Ser Leu Ile Lys Thr 
            900                 905                 910         


Glu Tyr Thr Glu Arg Asp Glu Glu Arg Phe Ile Asn Arg Gln Leu Val 
        915                 920                 925             


Glu Thr Arg Gln Ile Thr Lys Asn Val Thr Gln Ile Ile Glu Asp His 
    930                 935                 940                 


Tyr Ser Thr Thr Lys Val Ala Ala Ile Arg Ala Asn Leu Ser His Glu 
945                 950                 955                 960 


Phe Arg Val Lys Asn His Ile Tyr Lys Asn Arg Asp Ile Asn Asp Tyr 
                965                 970                 975     


His His Ala His Asp Ala Tyr Ile Val Ala Leu Ile Gly Gly Phe Met 
            980                 985                 990         


Arg Asp Arg Tyr Pro Asn Met His  Asp Ser Lys Ala Val  Tyr Ser Glu 
        995                 1000                 1005             


Tyr Met  Lys Met Phe Arg Lys  Asn Lys Asn Asp Gln  Lys Arg Trp 
    1010                 1015                 1020             


Lys Asp  Gly Phe Val Ile Asn  Ser Met Asn Tyr Pro  Tyr Glu Val 
    1025                 1030                 1035             


Asp Gly  Lys Leu Ile Trp Asn  Pro Asp Leu Ile Asn  Glu Ile Lys 
    1040                 1045                 1050             


Lys Cys  Phe Tyr Tyr Lys Asp  Cys Tyr Cys Thr Thr  Lys Leu Asp 
    1055                 1060                 1065             


Gln Lys  Ser Gly Gln Leu Phe  Asn Leu Thr Val Leu  Ser Asn Asp 
    1070                 1075                 1080             


Ala His  Ala Asp Lys Gly Val  Thr Lys Ala Val Val  Pro Val Asn 
    1085                 1090                 1095             


Lys Asn  Arg Ser Asp Val His  Lys Tyr Gly Gly Phe  Ser Gly Leu 
    1100                 1105                 1110             


Gln Tyr  Thr Ile Val Ala Ile  Glu Gly Gln Lys Lys  Lys Gly Lys 
    1115                 1120                 1125             


Lys Thr  Glu Leu Val Lys Lys  Ile Ser Gly Val Pro  Leu His Leu 
    1130                 1135                 1140             


Lys Ala  Ala Ser Ile Asn Glu  Lys Ile Asn Tyr Ile  Glu Glu Lys 
    1145                 1150                 1155             


Glu Gly  Leu Ser Asp Val Arg  Ile Ile Lys Asp Asn  Ile Pro Val 
    1160                 1165                 1170             


Asn Gln  Met Ile Glu Met Asp  Gly Gly Glu Tyr Leu  Leu Thr Ser 
    1175                 1180                 1185             


Pro Thr  Glu Tyr Val Asn Ala  Arg Gln Leu Val Leu  Asn Glu Lys 
    1190                 1195                 1200             


Gln Cys  Ala Leu Ile Ala Asp  Ile Tyr Asn Ala Ile  Tyr Lys Gln 
    1205                 1210                 1215             


Asp Tyr  Asp Asn Leu Asp Asp  Ile Leu Met Ile Gln  Leu Tyr Ile 
    1220                 1225                 1230             


Glu Leu  Thr Asn Lys Met Lys  Val Leu Tyr Pro Ala  Tyr Arg Gly 
    1235                 1240                 1245             


Ile Ala  Glu Lys Phe Glu Ser  Met Asn Glu Asn Tyr  Val Val Ile 
    1250                 1255                 1260             


Ser Lys  Glu Glu Lys Ala Asn  Ile Ile Lys Gln Met  Leu Ile Val 
    1265                 1270                 1275             


Met His  Arg Gly Pro Gln Asn  Gly Asn Ile Val Tyr  Asp Asp Phe 
    1280                 1285                 1290             


Lys Ile  Ser Asp Arg Ile Gly  Arg Leu Lys Thr Lys  Asn His Asn 
    1295                 1300                 1305             


Leu Asn  Asn Ile Val Phe Ile  Ser Gln Ser Pro Thr  Gly Ile Tyr 
    1310                 1315                 1320             


Thr Lys  Lys Tyr Lys Leu 
    1325                 


<210>  237
<211>  1389
<212>  PRT
<213>  Unknown

<220>
<223>  Cloning vector pYB196

<400>  237

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Gly Gly  Ser Gly Pro Pro Lys  Lys Lys Arg Lys Val  Tyr Pro Tyr 
    1370                 1375                 1380             


Asp Val  Pro Asp Tyr Ala 
    1385                 


<210>  238
<211>  1335
<212>  PRT
<213>  Unknown

<220>
<223>  Clostridiales bacterium S5-A11

<400>  238

Met Lys Asn Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Lys Asp Asp Leu Thr Leu Val Arg Lys Lys Ile Lys 
            20                  25                  30          


Ile Ser Gly Asn Thr Asp Lys Lys Glu Val Lys Lys Asn Leu Trp Gly 
        35                  40                  45              


Ser Phe Leu Phe Glu Gln Gly Asp Thr Ala Gln Asp Thr Arg Val Lys 
    50                  55                  60                  


Arg Ile Ala Arg Arg Arg Tyr Glu Arg Arg Arg Phe Arg Ile Arg Glu 
65                  70                  75                  80  


Leu Gln Lys Ile Phe Asp Lys Ser Met Gly Glu Val Asp Ser Asn Phe 
                85                  90                  95      


Phe His Arg Leu Asp Glu Ser Phe Leu Val Glu Glu Asp Lys Glu Tyr 
            100                 105                 110         


Ser Lys Tyr Pro Ile Phe Ser Asn Glu Lys Glu Asp Lys Asn Tyr Tyr 
        115                 120                 125             


Asp Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Asp Leu Ala Asp Ser 
    130                 135                 140                 


Asn Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Asp Leu Lys Met Asp 
                165                 170                 175     


Gly Ile Ser Ile Ser Glu Ser Phe Gln Glu Phe Ile Asp Ser Tyr Asn 
            180                 185                 190         


Glu Val Cys Ala Leu Glu Asp Glu Asn Leu Glu Ile Ile Tyr Asn Asp 
        195                 200                 205             


Glu Leu Leu Thr Gln Ile Glu Asn Ile Phe Lys Gln Asp Ile Ser Arg 
    210                 215                 220                 


Ser Lys Lys Leu Asp Gln Ala Ile Ala Leu Phe Gln Gly Val Lys Arg 
225                 230                 235                 240 


Gln Ser Leu Phe Gly Ile Phe Leu Thr Leu Ile Val Gly Asn Lys Ala 
                245                 250                 255     


Asn Phe Gln Lys Ile Phe Asn Leu Glu Asp Asp Ile Lys Leu Asp Leu 
            260                 265                 270         


Lys Glu Glu Asp Tyr Asp Glu Asn Leu Glu Glu Leu Leu Ser Asn Ile 
        275                 280                 285             


Asp Glu Gly Tyr Arg Asp Val Phe Leu Gln Ala Lys Asn Val Tyr Asn 
    290                 295                 300                 


Ala Ile Glu Leu Ser Lys Ile Leu Lys Thr Asp Gly Lys Glu Thr Lys 
305                 310                 315                 320 


Ala Pro Leu Ser Ala Gln Met Val Glu Leu Tyr Asn Gln His Arg Glu 
                325                 330                 335     


Asp Leu Lys Lys Tyr Lys Asp Tyr Ile Lys Ala Tyr Leu Pro Glu Lys 
            340                 345                 350         


Tyr Gly Glu Thr Phe Lys Asp Ala Thr Lys Asn Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Ser Gln Glu Asp Phe Tyr Lys Phe Val Lys Ala 
    370                 375                 380                 


Gln Leu Lys Gly Glu Glu Asn Gly Glu Tyr Phe Leu Glu Ala Ile Glu 
385                 390                 395                 400 


Asn Glu Asn Phe Leu Arg Lys Gln Arg Ser Phe Tyr Asn Gly Val Ile 
                405                 410                 415     


Pro Tyr Gln Ile His Leu Gln Glu Leu Thr Ala Val Leu Asp Gln Gln 
            420                 425                 430         


Glu Lys His Tyr Ser Phe Leu Lys Glu Asn Arg Asp Lys Ile Ile Ser 
        435                 440                 445             


Leu Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Gly 
    450                 455                 460                 


Glu Ser Arg Phe Ala Trp Leu Glu Arg Ser Asn Ser Glu Glu Lys Ile 
465                 470                 475                 480 


Lys Pro Trp Asn Phe Asp Lys Ile Val Asp Ile Asp Lys Ser Ala Glu 
                485                 490                 495     


Leu Phe Ile Glu Asn Leu Thr Ser Arg Asp Thr Tyr Leu Pro Asp Glu 
            500                 505                 510         


Pro Val Leu Pro Lys Arg Ser Leu Ile Tyr Gln Lys Phe Thr Ile Phe 
        515                 520                 525             


Asn Glu Leu Thr Lys Ile Ser Tyr Ile Asp Glu Arg Gly Ile Leu Gln 
    530                 535                 540                 


Asn Phe Ser Ser Arg Glu Lys Ile Ala Ile Phe Asn Asp Leu Phe Lys 
545                 550                 555                 560 


Asn Lys Ser Lys Val Thr Lys Asn Gln Leu Val Lys Tyr Ile Glu Asn 
                565                 570                 575     


Lys Glu Gln Ile Ile Ala Pro Glu Ile Lys Gly Ile Glu Asp Ser Phe 
            580                 585                 590         


Asn Ser Asn Tyr Ser Thr Tyr Ile Asp Leu Ser Lys Ile Pro Asp Met 
        595                 600                 605             


Lys Lys Leu Leu Glu Lys Asp Glu Asp Glu Ile Leu Glu Glu Ile Ile 
    610                 615                 620                 


Lys Ile Leu Thr Ile Phe Glu Asp Arg Lys Met Arg Lys Arg Gln Leu 
625                 630                 635                 640 


Met Lys Phe Lys Asp Lys Leu Ser Glu Lys Ala Ile Asn Gln Leu Ser 
                645                 650                 655     


Lys Lys His Tyr Thr Gly Trp Gly Gln Leu Ser Glu Lys Leu Ile Asn 
            660                 665                 670         


Gly Ile Arg Asp Glu Gln Ser Asn Lys Thr Ile Leu Asp Tyr Leu Ile 
        675                 680                 685             


Glu Asp Asn Gly Cys Pro Lys Asn Met Asn Arg Asn Phe Met Gln Leu 
    690                 695                 700                 


Ile Asn Asp Asp Thr Leu Ser Phe Lys Glu Lys Ile Arg Lys Ala Gln 
705                 710                 715                 720 


Asp Ile Asn Gln Val Asn Asp Ile Lys Glu Ile Val Lys Asp Leu Pro 
                725                 730                 735     


Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser Ile Arg Ile Val 
            740                 745                 750         


Asp Glu Ile Ile Arg Lys Met Lys Asp Arg Pro Lys Asn Ile Val Ile 
        755                 760                 765             


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Glu Gly Lys Asn Lys Ser 
    770                 775                 780                 


Lys Ala Arg Leu Lys Lys Ile Gln Glu Gly Leu Glu Asn Leu Asp Ser 
785                 790                 795                 800 


Val His Val Glu Lys Gln Ala Leu Asp Glu Glu Met Leu Lys Ser Pro 
                805                 810                 815     


Lys Tyr Tyr Leu Tyr Cys Leu Gln Asn Gly Lys Asp Ile Tyr Thr Gly 
            820                 825                 830         


Lys Asp Leu Asp Ile Gly Gln Leu Gln Thr Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Arg Ser Phe Ile Thr Asp Asn Ser Phe Asp Asn Leu Val Leu 
    850                 855                 860                 


Thr Ser Ser Thr Val Asn Arg Gly Lys Leu Asp Asn Val Pro Ser Pro 
865                 870                 875                 880 


Asp Ile Val Arg Gln Gln Lys Gly Phe Trp Lys Gln Leu Leu Arg Ala 
                885                 890                 895     


Gly Leu Met Ser Gln Arg Lys Phe Asn Asn Leu Thr Lys Gly Lys Leu 
            900                 905                 910         


Thr Asp Arg Asp Arg Gln Gln Phe Ile Asn Arg Gln Leu Val Glu Thr 
        915                 920                 925             


Arg Gln Ile Thr Lys His Val Ala Asn Leu Leu Ser His His Leu Asn 
    930                 935                 940                 


Glu Lys Lys Glu Val Gly Glu Ile Asn Ile Val Leu Leu Lys Ser Ala 
945                 950                 955                 960 


Leu Thr Ser Gln Phe Arg Lys Lys Phe Asp Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Gly Val Ile 
            980                 985                 990         


Ala Leu Lys Leu Leu Glu Leu Tyr  Pro Tyr Met Ala Lys  Asp Leu Ile 
        995                 1000                 1005             


Tyr Gly  Lys Tyr Ser Tyr His  Arg Lys Ile Glu Gly  Asp Lys Ala 
    1010                 1015                 1020             


Thr Gln  Ala Lys Tyr Lys Met  Ser Asn Ile Ile Glu  Arg Phe Ser 
    1025                 1030                 1035             


Gln Asp  Leu Leu Ala Asn Pro  Asp Gly Glu Ile Ala  Trp Glu Lys 
    1040                 1045                 1050             


Asp Lys  Asp Leu Asn Thr Ile  Arg Lys Val Leu Ser  Ser Lys Gln 
    1055                 1060                 1065             


Ile Asn  Ile Ile Lys Lys Ala  Glu Glu Gly Lys Gly  Arg Leu Phe 
    1070                 1075                 1080             


Lys Glu  Thr Ile Asn Ser Arg  Pro Ser Lys Lys Thr  Glu Lys Arg 
    1085                 1090                 1095             


Ile Pro  Ile Lys Asn Asn Leu  Asp Pro Asn Ile Tyr  Gly Gly Tyr 
    1100                 1105                 1110             


Ile Glu  Glu Lys Met Ala Tyr  Tyr Ile Ala Ile Asn  Tyr Leu Glu 
    1115                 1120                 1125             


Asn Gly  Lys Thr Lys Lys Ala  Ile Val Gly Ile Ser  Ile Lys Asp 
    1130                 1135                 1140             


Lys Lys  Asp Phe Glu Gly Gln  Thr Thr Glu Tyr Leu  Gly Lys Ile 
    1145                 1150                 1155             


Gly Phe  Asn Lys Ala Ser Ile  Ile Asn Ser Phe Lys  Asn Tyr Thr 
    1160                 1165                 1170             


Leu Phe  Glu Leu Glu Asn Gly  Ser Arg Arg Met Ile  Val Gly Ala 
    1175                 1180                 1185             


Ser Lys  Glu Asn Asp Ser Lys  Gly Glu Leu Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Tyr  Leu Pro Gln Asn Leu  Leu Glu Phe Val Tyr  His Leu Lys 
    1205                 1210                 1215             


His Tyr  Asn Glu Asp Glu Thr  Ser His Lys Phe Ile  Val Glu His 
    1220                 1225                 1230             


Lys Ala  Tyr Phe Asp Glu Leu  Leu Asn Tyr Ile Val  Glu Phe Ala 
    1235                 1240                 1245             


Asn Lys  Tyr Leu Glu Leu Glu  Asn Ser Ile Glu Lys  Ile Lys Asp 
    1250                 1255                 1260             


Leu Tyr  His Gly Lys Gly Pro  Asp Val Glu Glu Lys  Glu Leu Val 
    1265                 1270                 1275             


Glu Ser  Phe Ile Asn Leu Leu  Ala Ile Thr Lys Cys  Gly Pro Ala 
    1280                 1285                 1290             


Ala Asp  Ile Thr Phe Leu Gly  Glu Lys Ile Ser Arg  Lys Arg Tyr 
    1295                 1300                 1305             


Arg Ser  Thr Asn Cys Leu Trp  Gly Ser Glu Val Ile  Phe Gln Ser 
    1310                 1315                 1320             


Pro Thr  Gly Leu Tyr Glu Thr  Arg Leu Arg Leu Glu  
    1325                 1330                 1335 


<210>  239
<211>  1384
<212>  PRT
<213>  Unknown

<220>
<223>  CRISPR-mediated gene targeting vector p(bhsp68-Cas9)

<400>  239

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val Ser Ser Gly  Gly Ala Ala 
    1370                 1375                 1380             


Gly 
    


<210>  240
<211>  1332
<212>  PRT
<213>  Dolosigranulum pigrum

<400>  240

Met Gln Lys Asn Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Lys Asp Asp Tyr Thr Leu Ile Arg Lys Arg Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Ile Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Glu Thr Ala Lys Glu Thr Arg Leu 
    50                  55                  60                  


Lys Arg Gly Thr Arg Arg Arg Tyr Gln Arg Arg Arg Asn Arg Leu Ile 
65                  70                  75                  80  


Tyr Leu Gln Asp Ile Phe Gln Gln Pro Met Leu Ala Ile Asp Glu Asn 
                85                  90                  95      


Phe Phe His Arg Leu Asp Asp Ser Phe Phe Val Pro Asp Asp Lys Ser 
            100                 105                 110         


Tyr Asp Arg His Pro Ile Phe Gly Ser Leu Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Asn Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Ala Asp Leu Arg Leu Val Tyr Thr Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Thr Ser Ile Ser Glu Thr Phe Glu Gln Phe Leu Asp Thr Tyr 
            180                 185                 190         


Ser Asp Ile Phe Lys Glu Gln Leu Val Gly Asp Ile Ser Lys Val Glu 
        195                 200                 205             


Glu Ile Leu Ser Ser Lys Gln Ser Arg Ser Arg Lys His Glu Gln Ile 
    210                 215                 220                 


Met Ala Leu Phe Pro Asn Glu Asn Lys Leu Gly Asn Phe Gly Arg Phe 
225                 230                 235                 240 


Met Met Leu Ile Val Gly Asn Thr Ser Asn Phe Lys Pro Val Phe Asp 
                245                 250                 255     


Leu Asp Asp Glu Tyr Lys Leu Lys Leu Ser Asp Glu Thr Tyr Glu Glu 
            260                 265                 270         


Asp Leu Asp Thr Leu Leu Gly Met Thr Asp Asp Val Phe Leu Asp Val 
        275                 280                 285             


Phe Met Ala Ala Lys Asn Val Tyr Asp Ala Val Glu Met Ser Ala Ile 
    290                 295                 300                 


Ile Ser Thr Asp Thr Gly Asn Ser Lys Ala Val Leu Ser Asn Gln Met 
305                 310                 315                 320 


Ile Asn Phe Tyr Asp Glu His Lys Val Asp Leu Ala Gln Leu Lys Gln 
                325                 330                 335     


Phe Phe Lys Thr His Leu Pro Asp Lys Tyr Tyr Glu Cys Phe Ser Asp 
            340                 345                 350         


Pro Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn Gln 
        355                 360                 365             


Glu Asp Phe Tyr Lys Tyr Ile Glu Lys Val Met Lys Thr Ile Lys Ser 
    370                 375                 380                 


Asp Lys Lys Asp Tyr Phe Leu Asp Lys Ile Asp Arg Glu Val Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Ser Phe Tyr Asn Ser Val Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Gln Ala Ile Leu Asp Arg Gln Ser Gln Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Ala Glu Asn Arg Asp Lys Ile Glu Ser Leu Val Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Thr Val Ser Asp Gln Ser Glu Phe 
    450                 455                 460                 


Ala Trp Met Glu Arg Gln Ser Asp Glu Pro Ile Arg Pro Trp Asn Phe 
465                 470                 475                 480 


Asp Glu Ile Val Asn Lys Glu Arg Ser Ala Glu Lys Phe Ile Glu Arg 
                485                 490                 495     


Met Thr Asn Met Asp Thr Tyr Leu Leu Glu Glu Lys Val Leu Pro Lys 
            500                 505                 510         


Arg Ser Leu Leu Tyr Gln Thr Phe Glu Val Tyr Asn Glu Leu Thr Lys 
        515                 520                 525             


Val Arg Tyr Thr Asn Glu Gln Gly Lys Thr Glu Lys Leu Asn Arg Gln 
    530                 535                 540                 


Gln Lys Ala Glu Ile Ile Glu Thr Leu Phe Lys Gln Lys Asn Arg Val 
545                 550                 555                 560 


Arg Glu Lys Asp Ile Ala Asn Tyr Leu Glu Gln Tyr Gly Tyr Val Asp 
                565                 570                 575     


Gly Thr Asp Ile Lys Gly Val Glu Asp Lys Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr Asn Asp Leu Ala Lys Ile Asp Gly Ala Lys Ala Tyr Leu Asp 
        595                 600                 605             


Asp Pro Glu Tyr Ala Asp Val Trp Glu Asp Ile Ile Lys Ile Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Lys Ala Met Arg Lys Lys Gln Leu Gln Thr Tyr Ser 
625                 630                 635                 640 


Asp Thr Leu Ser Pro Glu Ile Leu Lys Lys Leu Glu Arg Lys His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Phe Ser Lys Lys Leu Ile Asn Gly Leu Arg Asp 
            660                 665                 670         


Glu Gly Ser Asn Lys Thr Ile Leu Asp Tyr Leu Lys Ser Asp Glu Gly 
        675                 680                 685             


Ser Ser Gly Pro Thr Asn Arg Asn Phe Met Gln Leu Ile Arg Asp Asn 
    690                 695                 700                 


Thr Leu Ser Phe Lys Lys Lys Ile Glu Asp Ala Gln Thr Ile Glu Asp 
705                 710                 715                 720 


Thr Thr His Ile Tyr Asp Thr Val Ala Glu Leu Pro Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Arg Gln Ala Leu Lys Ile Val Glu Glu Ile Ile 
            740                 745                 750         


Asp Ile Ile Gly Tyr Glu Pro Glu Asn Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Ser Gln Thr Thr Lys Lys Gly Lys Asp Leu Ser Lys Glu Arg Leu 
    770                 775                 780                 


Glu Lys Leu Thr Glu Ala Ile Lys Glu Phe Asp Gly Pro Ser Asp Val 
785                 790                 795                 800 


Lys Val Lys Asp Leu Lys Asn Glu Asn Leu Arg Asn Asp Arg Leu Tyr 
                805                 810                 815     


Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Asn Glu Pro Leu 
            820                 825                 830         


Asp Ile Asn Asn Leu Ser Lys Tyr Asp Ile Asp His Ile Ile Pro Gln 
        835                 840                 845             


Ser Phe Thr Thr Asp Asn Ser Ile Asp Asn Lys Val Leu Val Ser Arg 
    850                 855                 860                 


Thr Lys Asn Gln Gly Asn Lys Ser Asp Asp Val Pro Ser Ile Asn Ile 
865                 870                 875                 880 


Val His Lys Met Lys Pro Phe Trp Arg Gln Leu His Lys Ala Gly Leu 
                885                 890                 895     


Ile Ser Asp Arg Lys Phe Lys Asn Leu Thr Lys Ala Glu His Gly Gly 
            900                 905                 910         


Leu Thr Glu Ala Asp Arg Ala His Phe Leu Asn Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Asn Leu Leu Asp Ser Gln Tyr 
    930                 935                 940                 


Asn Thr Ala Glu Glu Gln Arg Ile Asn Ile Val Leu Leu Lys Ser Ser 
945                 950                 955                 960 


Met Thr Ser Arg Phe Arg Lys Glu Phe Lys Leu Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Gly His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Ala Thr Thr Ile Met Lys Val Tyr  Pro Asn Leu Lys Pro  Gln Phe Val 
        995                 1000                 1005             


Tyr Gly  Gln Tyr Lys Lys Thr  Ser Met Phe Lys Glu  Glu Lys Ala 
    1010                 1015                 1020             


Thr Ala  Arg Lys His Phe Tyr  Ser Asn Ile Thr Lys  Phe Phe Lys 
    1025                 1030                 1035             


Lys Glu  Lys Val Val Asn Glu  Glu Thr Gly Glu Ile  Leu Trp Asp 
    1040                 1045                 1050             


Thr Glu  Arg His Leu Ser Thr  Ile Lys Arg Val Leu  Ser Trp Lys 
    1055                 1060                 1065             


Gln Met  Asn Ile Val Lys Lys  Val Glu Lys Gln Lys  Gly Gln Leu 
    1070                 1075                 1080             


Trp Lys  Glu Thr Ile Tyr Pro  Lys Gly Asp Ser Ser  Lys Leu Ile 
    1085                 1090                 1095             


Pro Val  Lys Glu Gly Met Asp  Pro Gln Lys Tyr Gly  Gly Leu Ser 
    1100                 1105                 1110             


Gln Val  Ser Glu Ala Phe Ala  Val Val Ile Thr His  Glu Lys Gly 
    1115                 1120                 1125             


Lys Lys  Lys Gln Leu Lys Ser  Asp Leu Ile Ser Ile  Pro Ile Val 
    1130                 1135                 1140             


Asp Gln  Lys Ala Tyr Glu Gln  His Pro Thr Ala Tyr  Leu Glu Glu 
    1145                 1150                 1155             


Ala Gly  Tyr Asn Asn Pro Thr  Val Leu His Glu Leu  Phe Lys Tyr 
    1160                 1165                 1170             


Gln Leu  Phe Glu Leu Glu Asp  Gly Ser Arg Arg Met  Ile Ala Ser 
    1175                 1180                 1185             


Ala Lys  Glu Phe Gln Lys Gly  Asn Gln Met Val Leu  Pro Leu Glu 
    1190                 1195                 1200             


Leu Val  Glu Leu Leu Tyr His  Ala Asn Arg Tyr Asp  Lys Val Lys 
    1205                 1210                 1215             


Phe Pro  Asp Ser Ile Glu Tyr  Val His Asp Asn Leu  Ala Lys Phe 
    1220                 1225                 1230             


Asp Asp  Leu Leu Glu Tyr Val  Ile Asp Phe Ser Asn  Lys Tyr Ile 
    1235                 1240                 1245             


Asn Ala  Asp Lys Asn Val Gln  Lys Ile Gln Lys Ile  Tyr Lys Glu 
    1250                 1255                 1260             


His Gly  Thr Glu Asp Val Glu  Leu Thr Val Glu Ser  Phe Val Asn 
    1265                 1270                 1275             


Leu Met  Thr Phe Thr Ala Met  Gly Ala Pro Ala Thr  Phe Lys Phe 
    1280                 1285                 1290             


Tyr Gly  Glu Ser Ile Thr Arg  Ser Arg Tyr Thr Ser  Ile Thr Glu 
    1295                 1300                 1305             


Phe Arg  Gly Ser Thr Leu Ile  Phe Gln Ser Ile Thr  Gly Leu Tyr 
    1310                 1315                 1320             


Glu Thr  Arg Tyr Lys Leu Glu  Asp Asn 
    1325                 1330         


<210>  241
<211>  1337
<212>  PRT
<213>  Unknown

<220>
<223>  MULTISPECIES: Enterococcus

<400>  241

Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Asp Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Gly Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Asn Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Thr Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Ile Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210>  242
<211>  1288
<212>  PRT
<213>  Unknown

<220>
<223>  MULTISPECIES: Enterococcus

<400>  242

Met Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu Lys 
1               5                   10                  15      


Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg Tyr 
            20                  25                  30          


Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Asp Leu Asp Glu Asn Phe 
        35                  40                  45              


Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys Trp 
    50                  55                  60                  


His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr His 
65                  70                  75                  80  


Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp Ser 
                85                  90                  95      


Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Ile 
            100                 105                 110         


Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr Glu 
        115                 120                 125             


Asn Thr Ser Val Lys Asp Gln Phe Gln Gln Phe Met Val Ile Tyr Asn 
    130                 135                 140                 


Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu Pro 
145                 150                 155                 160 


Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg Thr 
                165                 170                 175     


Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala Asn 
            180                 185                 190         


Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala Asp 
        195                 200                 205             


Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr Ala 
    210                 215                 220                 


Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val Gly 
225                 230                 235                 240 


Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp Ala 
                245                 250                 255     


Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His Ala 
            260                 265                 270         


Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu Asp 
        275                 280                 285             


Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu Tyr 
    290                 295                 300                 


Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr Ile 
305                 310                 315                 320 


Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val Lys 
                325                 330                 335     


Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys Ile 
            340                 345                 350         


Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val 
        355                 360                 365             


Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His Arg 
    370                 375                 380                 


Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile Glu 
385                 390                 395                 400 


Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser Lys 
                405                 410                 415     


Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu Pro 
            420                 425                 430         


Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser Ala 
        435                 440                 445             


Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro Ser 
    450                 455                 460                 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met Val 
465                 470                 475                 480 


Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile Lys 
                485                 490                 495     


Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu Phe 
            500                 505                 510         


Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr Arg 
        515                 520                 525             


Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu Asp 
    530                 535                 540                 


Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys Gly 
545                 550                 555                 560 


Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu Glu 
                565                 570                 575     


Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile Arg 
            580                 585                 590         


Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu Lys 
        595                 600                 605             


Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys Lys 
    610                 615                 620                 


Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu Asp 
625                 630                 635                 640 


Tyr Leu Val Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn Phe 
                645                 650                 655     


Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile Gln 
            660                 665                 670         


Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val Asn 
        675                 680                 685             


Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser Leu 
    690                 695                 700                 


Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys Arg 
705                 710                 715                 720 


Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly Lys 
                725                 730                 735     


Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala Glu 
            740                 745                 750         


Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln Leu 
        755                 760                 765             


Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp Met 
    770                 775                 780                 


Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp Ile 
785                 790                 795                 800 


Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp Asn 
                805                 810                 815     


Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp Val 
            820                 825                 830         


Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys Leu 
        835                 840                 845             


Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr Lys 
    850                 855                 860                 


Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile Gln 
865                 870                 875                 880 


Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly Ile 
                885                 890                 895     


Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln Ile 
            900                 905                 910         


Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe Gly 
        915                 920                 925             


Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp Ala 
    930                 935                 940                 


Tyr Leu Asn Cys Val Val Ala Thr Thr Leu Leu Lys Val Tyr Pro Asn 
945                 950                 955                 960 


Leu Ala Pro Glu Phe Val Tyr Gly Glu Tyr Pro Lys Phe Gln Thr Phe 
                965                 970                 975     


Lys Glu Asn Lys Ala Thr Ala Lys Ala Ile Ile Tyr Thr Asn Leu Leu 
            980                 985                 990         


Arg Phe Phe Thr Glu Asp Glu Pro  Arg Phe Thr Lys Asp  Gly Glu Ile 
        995                 1000                 1005             


Leu Trp  Ser Asn Ser Tyr Leu  Lys Thr Ile Lys Lys  Glu Leu Asn 
    1010                 1015                 1020             


Tyr His  Gln Met Asn Ile Val  Lys Lys Val Glu Val  Gln Lys Gly 
    1025                 1030                 1035             


Gly Phe  Ser Lys Glu Ser Ile  Lys Pro Lys Gly Pro  Ser Asn Lys 
    1040                 1045                 1050             


Leu Ile  Pro Val Lys Asn Gly  Leu Asp Pro Gln Lys  Tyr Gly Gly 
    1055                 1060                 1065             


Phe Asp  Ser Pro Val Val Ala  Tyr Thr Val Leu Phe  Thr His Glu 
    1070                 1075                 1080             


Lys Gly  Lys Lys Pro Leu Ile  Lys Gln Glu Ile Leu  Gly Ile Thr 
    1085                 1090                 1095             


Ile Met  Glu Lys Thr Arg Phe  Glu Gln Asn Pro Ile  Leu Phe Leu 
    1100                 1105                 1110             


Glu Glu  Lys Gly Phe Leu Arg  Pro Arg Val Leu Met  Lys Leu Pro 
    1115                 1120                 1125             


Lys Tyr  Thr Leu Tyr Glu Phe  Pro Glu Gly Arg Arg  Arg Leu Leu 
    1130                 1135                 1140             


Ala Ser  Ala Lys Glu Ala Gln  Lys Gly Asn Gln Met  Val Leu Pro 
    1145                 1150                 1155             


Glu His  Leu Leu Thr Leu Leu  Tyr His Ala Lys Gln  Cys Leu Leu 
    1160                 1165                 1170             


Pro Asn  Gln Ser Glu Ser Leu  Ala Tyr Val Glu Gln  His Gln Pro 
    1175                 1180                 1185             


Glu Phe  Gln Glu Ile Leu Glu  Arg Val Val Asp Phe  Ala Glu Val 
    1190                 1195                 1200             


His Thr  Leu Ala Lys Ser Lys  Val Gln Gln Ile Val  Lys Leu Phe 
    1205                 1210                 1215             


Glu Ala  Asn Gln Thr Ala Asp  Val Lys Glu Ile Ala  Ala Ser Phe 
    1220                 1225                 1230             


Ile Gln  Leu Met Gln Phe Asn  Ala Met Gly Ala Pro  Ser Thr Phe 
    1235                 1240                 1245             


Lys Phe  Phe Gln Lys Asp Ile  Glu Arg Ala Arg Tyr  Thr Ser Ile 
    1250                 1255                 1260             


Lys Glu  Ile Phe Asp Ala Thr  Ile Ile Tyr Gln Ser  Pro Thr Gly 
    1265                 1270                 1275             


Leu Tyr  Glu Thr Arg Arg Lys  Val Val Asp 
    1280                 1285             


<210>  243
<211>  1079
<212>  PRT
<213>  Unknown

<220>
<223>  Enterococcus durans IPLA 655

<400>  243

Met Asp Glu Glu Ala Lys Ile Gln Leu Ser Lys Glu Ser Tyr Glu Glu 
1               5                   10                  15      


Glu Leu Glu Ser Leu Leu Glu Lys Ser Gly Glu Glu Phe Arg Asp Val 
            20                  25                  30          


Phe Leu Gln Ala Lys Lys Val Tyr Asp Ala Ile Leu Leu Ser Asp Ile 
        35                  40                  45              


Leu Ser Thr Lys Lys Gln Asn Ser Lys Ala Lys Leu Ser Leu Gly Met 
    50                  55                  60                  


Ile Glu Arg Tyr Asp Ser His Lys Lys Asp Leu Glu Glu Leu Lys Gln 
65                  70                  75                  80  


Phe Val Lys Ala Asn Leu Pro Glu Lys Thr Ala Ile Phe Phe Lys Asp 
                85                  90                  95      


Ser Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Thr Gln 
            100                 105                 110         


Glu Asp Phe Tyr Lys Phe Leu Lys Lys Glu Leu Asn Gly Ile Ala Gly 
        115                 120                 125             


Ser Glu Arg Phe Met Glu Lys Val Asp Gln Glu Asn Phe Leu Leu Lys 
    130                 135                 140                 


Gln Arg Thr Thr Ala Asn Gly Val Ile Pro His Gln Val His Leu Thr 
145                 150                 155                 160 


Glu Leu Lys Ala Ile Ile Glu Arg Gln Lys Pro Tyr Tyr Pro Ser Leu 
                165                 170                 175     


Glu Glu Ala Arg Asp Lys Met Ile Arg Leu Leu Thr Phe Arg Ile Pro 
            180                 185                 190         


Tyr Tyr Val Gly Pro Leu Ala Gln Gly Glu Glu Thr Ser Ser Phe Ala 
        195                 200                 205             


Trp Leu Glu Arg Lys Thr Pro Glu Lys Val Thr Pro Trp Asn Ala Thr 
    210                 215                 220                 


Glu Val Ile Asp Tyr Ser Ala Ser Ala Met Lys Phe Ile Gln Arg Met 
225                 230                 235                 240 


Ile Asn Tyr Asp Thr Tyr Leu Pro Thr Glu Lys Val Leu Pro Lys His 
                245                 250                 255     


Ser Ile Leu Tyr Gln Lys Tyr Thr Ile Phe Asn Glu Leu Thr Lys Val 
            260                 265                 270         


Ala Tyr Lys Asp Glu Arg Gly Ile Lys His Gln Phe Ser Ser Lys Glu 
        275                 280                 285             


Lys Arg Glu Ile Phe Lys Glu Leu Phe Gln Lys Gln Arg Lys Val Thr 
    290                 295                 300                 


Val Lys Lys Leu Gln Gln Phe Leu Ser Ala Asn Tyr Asn Ile Glu Asp 
305                 310                 315                 320 


Ala Glu Ile Leu Gly Val Asp Lys Ala Phe Asn Ser Ser Tyr Ala Thr 
                325                 330                 335     


Tyr His Asp Phe Leu Asp Leu Ala Lys Pro Asn Thr Glu Arg Val Ala 
            340                 345                 350         


Glu Leu Leu Glu Gln Pro Glu Met Asn Ala Met Phe Glu Asp Ile Val 
        355                 360                 365             


Lys Ile Leu Thr Ile Phe Glu Asp Arg Glu Met Ile Arg Thr Gln Leu 
    370                 375                 380                 


Lys Lys Tyr Gln Ser Val Leu Gly Asp Gly Phe Phe Lys Lys Leu Val 
385                 390                 395                 400 


Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Glu Arg Leu Ile Asn 
                405                 410                 415     


Gly Ile Arg Asp Lys Lys Thr Asn Lys Thr Ile Leu Asp Tyr Leu Ile 
            420                 425                 430         


Asp Asp Asp Asp Phe Pro Tyr Asn Arg Asn Arg Asn Phe Met Gln Leu 
        435                 440                 445             


Ile Asn Asp Asp Ser Leu Ser Phe Lys Glu Glu Leu Ala Asn Glu Leu 
    450                 455                 460                 


Ala Leu Ala Gly Asn Gln Ser Leu Leu Glu Val Val Glu Ala Leu Leu 
465                 470                 475                 480 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Trp Gln Thr Leu Lys Ile Val 
                485                 490                 495     


Glu Glu Leu Ile Glu Ile Ile Gly Tyr Asn Pro Lys Asn Ile Val Val 
            500                 505                 510         


Glu Met Ala Arg Glu Asn Gln Arg Thr Asn Arg Ser Lys Pro Arg Leu 
        515                 520                 525             


Lys Ala Leu Glu Glu Ala Leu Lys Ser Phe Asp Ser Pro Leu Leu Lys 
    530                 535                 540                 


Glu Gln Pro Val Asp Asn Gln Ala Leu Gln Lys Asp Arg Leu Tyr Leu 
545                 550                 555                 560 


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp 
                565                 570                 575     


Ile Asp Arg Leu Ser Glu Tyr Asp Ile Asp His Ile Ile Pro Arg Ser 
            580                 585                 590         


Phe Ile Val Asp Asn Ser Ile Asp Asn Lys Val Leu Val Ser Ser Lys 
        595                 600                 605             


Glu Asn Arg Leu Lys Met Asp Asp Val Pro Asp Gln Lys Val Val Ile 
    610                 615                 620                 


Arg Met Arg Arg Tyr Trp Glu Lys Leu Leu Arg Ala Asn Leu Ile Ser 
625                 630                 635                 640 


Glu Arg Lys Phe Ala Tyr Leu Thr Lys Leu Glu Leu Thr Pro Glu Asp 
                645                 650                 655     


Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
            660                 665                 670         


Lys His Val Ala Ala Ile Leu Asp Gln Tyr Phe Asn Gln Pro Glu Glu 
        675                 680                 685             


Ser Lys Asn Lys Gly Ile Arg Ile Ile Thr Leu Lys Ser Ser Leu Val 
    690                 695                 700                 


Ser Gln Phe Arg Lys Thr Phe Gly Ile Asn Lys Val Arg Glu Ile Asn 
705                 710                 715                 720 


Asn His His His Ala His Asp Ala Tyr Leu Asn Gly Val Val Ala Ile 
                725                 730                 735     


Ala Leu Leu Lys Lys Tyr Pro Lys Leu Glu Pro Glu Phe Val Tyr Gly 
            740                 745                 750         


Asn Tyr Thr Lys Phe Asn Leu Ala Thr Glu Asn Lys Ala Thr Ala Lys 
        755                 760                 765             


Lys Glu Phe Tyr Ser Asn Ile Leu Arg Phe Phe Glu Lys Glu Glu Tyr 
    770                 775                 780                 


Ser Tyr Asp Glu Asn Gly Glu Ile Phe Trp Asp Lys Ala Arg His Ile 
785                 790                 795                 800 


Pro Gln Ile Lys Lys Val Ile Ser Ser His Gln Val Asn Ile Val Lys 
                805                 810                 815     


Lys Val Glu Val Gln Thr Gly Gly Phe Tyr Lys Glu Thr Val Asn Pro 
            820                 825                 830         


Lys Gly Lys Pro Asp Lys Leu Ile Gln Arg Lys Ala Gly Trp Asp Val 
        835                 840                 845             


Ser Lys Tyr Gly Gly Phe Gly Ser Pro Val Val Ala Tyr Ala Val Ala 
    850                 855                 860                 


Phe Ile Tyr Glu Lys Gly Lys Ala Arg Lys Lys Ala Lys Ala Ile Glu 
865                 870                 875                 880 


Gly Ile Thr Ile Met Lys Gln Ser Leu Phe Glu Gln Asp Pro Ile Gly 
                885                 890                 895     


Phe Leu Ser Asn Lys Gly Tyr Ser Asn Val Thr Lys Phe Ile Lys Leu 
            900                 905                 910         


Ser Lys Tyr Thr Leu Tyr Glu Leu Glu Asn Gly Arg Arg Arg Met Val 
        915                 920                 925             


Ala Ser His Lys Glu Ala Gln Lys Ala Asn Ser Phe Ile Leu Pro Glu 
    930                 935                 940                 


Lys Leu Val Thr Leu Leu Tyr His Ala Gln His Tyr Asp Glu Ile Ala 
945                 950                 955                 960 


His Lys Glu Ser Phe Asp Tyr Val Asn Asp His Leu Ser Glu Phe Arg 
                965                 970                 975     


Glu Ile Leu Asp Gln Val Ile Asp Phe Ser Asn Arg Tyr Thr Ile Ala 
            980                 985                 990         


Ala Lys Asn Thr Glu Lys Ile Ala  Glu Leu Phe Glu Gln  Asn Gln Glu 
        995                 1000                 1005             


Ser Thr  Val Gln Ser Leu Ser  Gln Ser Phe Ile Asn  Leu Met Gln 
    1010                 1015                 1020             


Leu Asn  Ala Met Gly Ala Pro  Ala Asp Phe Lys Phe  Phe Asp Val 
    1025                 1030                 1035             


Ile Ile  Pro Arg Lys Arg Tyr  Pro Ser Leu Thr Glu  Ile Trp Glu 
    1040                 1045                 1050             


Ser Thr  Ile Ile Tyr Gln Ser  Ile Thr Gly Leu Arg  Glu Thr Arg 
    1055                 1060                 1065             


Thr Arg  Met Ala Thr Leu Trp  Asp Gly Glu Gln 
    1070                 1075                 


<210>  244
<211>  1337
<212>  PRT
<213>  Enterococcus faecalis

<400>  244

Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Asp Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Thr Ser Val Lys Glu Gln Phe Gln Gln Phe Met Val Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Val Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Lys Val Val Lys Lys Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Ala Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Thr Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Met Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Ser  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Val Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210>  245
<211>  1337
<212>  PRT
<213>  Enterococcus faecalis

<400>  245

Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Ala Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Asn Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Thr His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Asn Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Thr Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Ile Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Gln Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210>  246
<211>  1337
<212>  PRT
<213>  Enterococcus faecalis

<400>  246

Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Ala Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Thr Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Asn Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Thr His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Val Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Thr Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Ile Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210>  247
<211>  1337
<212>  PRT
<213>  Enterococcus faecalis

<400>  247

Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Asp Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Val Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asn Gln Arg Tyr Asn Ala Asn Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Thr Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Val Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210>  248
<211>  1339
<212>  PRT
<213>  Enterococcus faecalis

<400>  248

Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Ala Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Lys Ile 
            260                 265                 270         


Thr Tyr Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala 
        275                 280                 285             


Lys Val Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val 
    290                 295                 300                 


Tyr Asp Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys 
305                 310                 315                 320 


Ser His Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His 
                325                 330                 335     


Gln Glu Asp Leu Lys Asn Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro 
            340                 345                 350         


Asp Glu Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala 
        355                 360                 365             


Gly Tyr Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln 
    370                 375                 380                 


Tyr Val Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu 
385                 390                 395                 400 


Glu Lys Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile 
            420                 425                 430         


Ile His Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Lys 
        435                 440                 445             


Lys Ile Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Ser Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser 
465                 470                 475                 480 


Glu Glu Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp 
                485                 490                 495     


Gln Ser Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr 
            500                 505                 510         


Leu Pro Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys 
        515                 520                 525             


Phe Met Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg 
    530                 535                 540                 


Gly Ile Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp 
545                 550                 555                 560 


Tyr Leu Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln 
                565                 570                 575     


Phe Tyr Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu 
            580                 585                 590         


Glu Glu Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu 
        595                 600                 605             


Lys Cys Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu 
    610                 615                 620                 


Lys Leu Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln 
625                 630                 635                 640 


Arg Ile Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Glu Glu 
                645                 650                 655     


Val Leu Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Lys Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr 
        675                 680                 685             


Ile Leu Asp Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn 
    690                 695                 700                 


Arg Asn Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn 
705                 710                 715                 720 


Ala Ile Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu 
                725                 730                 735     


Thr Val Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr 
            740                 745                 750         


Gln Ser Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala 
        755                 760                 765             


Pro Lys Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser 
    770                 775                 780                 


Thr Gly Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala 
785                 790                 795                 800 


Met Ala Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn 
                805                 810                 815     


Glu Gln Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly 
            820                 825                 830         


Lys Asp Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His 
        835                 840                 845             


Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser 
    850                 855                 860                 


Leu Asp Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser 
865                 870                 875                 880 


Asp Asp Val Pro Ser Lys Glu Val Val Lys Lys Met Lys Ala Tyr Trp 
                885                 890                 895     


Glu Lys Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg 
            900                 905                 910         


Leu Thr Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His 
        915                 920                 925             


Phe Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val 
    930                 935                 940                 


Ala Gly Ile Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys 
945                 950                 955                 960 


Val Gln Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser 
                965                 970                 975     


Ile Phe Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly 
            980                 985                 990         


Gln Asp Ala Tyr Leu Asn Cys Val  Val Ala Thr Thr Leu  Leu Lys Val 
        995                 1000                 1005             


Tyr Pro  Asn Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Pro Lys 
    1010                 1015                 1020             


Phe Gln  Ala Phe Lys Glu Asn  Lys Ala Thr Ala Lys  Ala Ile Ile 
    1025                 1030                 1035             


Tyr Thr  Asn Leu Leu Arg Phe  Phe Thr Glu Asp Glu  Pro Arg Phe 
    1040                 1045                 1050             


Thr Lys  Asp Gly Glu Ile Leu  Trp Ser Asn Ser Tyr  Leu Lys Thr 
    1055                 1060                 1065             


Ile Lys  Lys Glu Leu Asn Tyr  His Gln Met Asn Ile  Val Lys Lys 
    1070                 1075                 1080             


Val Glu  Val Gln Lys Gly Gly  Phe Ser Lys Glu Ser  Ile Lys Pro 
    1085                 1090                 1095             


Lys Gly  Pro Ser Asn Lys Leu  Ile Pro Val Lys Asn  Gly Leu Asp 
    1100                 1105                 1110             


Pro Gln  Lys Tyr Gly Gly Phe  Asp Ser Pro Val Val  Ala Tyr Thr 
    1115                 1120                 1125             


Val Leu  Phe Thr His Glu Lys  Gly Lys Lys Pro Leu  Ile Lys Gln 
    1130                 1135                 1140             


Glu Ile  Leu Gly Ile Thr Ile  Met Glu Lys Thr Arg  Phe Glu Gln 
    1145                 1150                 1155             


Asn Pro  Ile Leu Phe Leu Glu  Glu Lys Gly Phe Leu  Arg Pro Arg 
    1160                 1165                 1170             


Val Leu  Met Lys Leu Pro Lys  Tyr Thr Leu Tyr Glu  Phe Pro Glu 
    1175                 1180                 1185             


Gly Arg  Arg Arg Leu Leu Ala  Ser Ala Lys Glu Ala  Gln Lys Gly 
    1190                 1195                 1200             


Asn Gln  Met Val Leu Pro Glu  His Leu Leu Thr Leu  Leu Tyr His 
    1205                 1210                 1215             


Ala Lys  Gln Cys Leu Leu Pro  Asn Gln Ser Glu Ser  Leu Ala Tyr 
    1220                 1225                 1230             


Val Glu  Gln His Gln Pro Glu  Phe Gln Glu Ile Leu  Glu Arg Val 
    1235                 1240                 1245             


Val Asp  Phe Ala Glu Val His  Thr Leu Ala Lys Ser  Lys Val Gln 
    1250                 1255                 1260             


Gln Ile  Val Lys Leu Phe Glu  Ala Asn Gln Thr Ala  Asp Val Lys 
    1265                 1270                 1275             


Glu Ile  Ala Ala Ser Phe Ile  Gln Leu Met Gln Phe  Asn Ala Met 
    1280                 1285                 1290             


Gly Ala  Pro Ser Thr Phe Lys  Phe Phe Gln Lys Asp  Ile Glu Arg 
    1295                 1300                 1305             


Ala Arg  Tyr Thr Ser Ile Lys  Glu Ile Phe Asp Ala  Thr Ile Ile 
    1310                 1315                 1320             


Tyr Gln  Ser Thr Thr Gly Leu  Tyr Glu Thr Arg Arg  Lys Val Val 
    1325                 1330                 1335             


Asp 
    


<210>  249
<211>  1337
<212>  PRT
<213>  Enterococcus faecalis

<400>  249

Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Ala Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Gly Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Thr Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Ile Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210>  250
<211>  1337
<212>  PRT
<213>  Enterococcus faecalis

<400>  250

Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Ser Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Asp Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Thr Ser Val Lys Asp Gln Phe Gln Gln Phe Met Val Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Asn Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Thr His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Leu Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Thr Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Thr Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Met Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Val Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210>  251
<211>  1337
<212>  PRT
<213>  Enterococcus faecalis

<400>  251

Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Ala Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Lys Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Gly Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser Tyr 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Val Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Thr Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Ile Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210>  252
<211>  1337
<212>  PRT
<213>  Enterococcus faecalis

<400>  252

Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Ala Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Asp Gln Phe Gln Gln Phe Met Val Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Asn Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Lys Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Lys Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Ala Phe  Lys Glu Asn Lys Ala  Met Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Val Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu Arg Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210>  253
<211>  1337
<212>  PRT
<213>  Enterococcus faecalis

<400>  253

Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Ala Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Asn Glu Lys 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Lys Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Ala Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Met Arg Phe Phe Thr  Glu Val Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Val Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Lys Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Thr Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210>  254
<211>  1337
<212>  PRT
<213>  Enterococcus faecalis

<400>  254

Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Ala Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Asn Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Lys Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Glu Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Lys Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Ala Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Val Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210>  255
<211>  1339
<212>  PRT
<213>  Enterococcus faecium

<400>  255

Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Asp Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Ala Lys Leu Gln Phe Ser Lys 
            260                 265                 270         


Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly Asp 
        275                 280                 285             


Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala Val 
    290                 295                 300                 


Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala Lys 
305                 310                 315                 320 


Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp Leu 
                325                 330                 335     


Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr Arg 
            340                 345                 350         


Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile Glu 
        355                 360                 365             


Gly His Ala Thr Gln Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu Leu 
    370                 375                 380                 


Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln Glu 
385                 390                 395                 400 


Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro His 
                405                 410                 415     


Gln Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys Lys 
            420                 425                 430         


His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu Leu 
        435                 440                 445             


Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln Glu 
    450                 455                 460                 


Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile Lys 
465                 470                 475                 480 


Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val Arg 
                485                 490                 495     


Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Met Pro His Asn Lys 
            500                 505                 510         


Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn Tyr 
    530                 535                 540                 


Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu Lys 
545                 550                 555                 560 


Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu Lys 
                565                 570                 575     


Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe Asn 
            580                 585                 590         


Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn Lys 
        595                 600                 605             


Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met Phe 
    610                 615                 620                 


Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met Ile 
625                 630                 635                 640 


Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile Ile 
                645                 650                 655     


Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu Ile 
705                 710                 715                 720 


Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile Val 
                725                 730                 735     


Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro Ala 
        755                 760                 765             


Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg Gly 
    770                 775                 780                 


Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu Lys 
785                 790                 795                 800 


Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser Ser 
                805                 810                 815     


Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp 
            820                 825                 830         


Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile Asp 
    850                 855                 860                 


Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp Asp 
865                 870                 875                 880 


Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr Asp 
                885                 890                 895     


Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu Thr 
            900                 905                 910         


Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu His 
    930                 935                 940                 


His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys Val 
945                 950                 955                 960 


Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn Arg 
                965                 970                 975     


Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Gly Val Val  Ala Leu Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Gln  Leu Ala Pro Glu Phe  Val Tyr Gly Glu Tyr  Leu Lys Phe 
    1010                 1015                 1020             


Asn Ala  His Lys Ala Asn Lys  Ala Thr Val Lys Lys  Glu Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Lys Phe Phe  Glu Ser Asp Thr Pro  Val Cys Asp 
    1040                 1045                 1050             


Glu Asn  Gly Glu Ile Phe Trp  Asp Lys Ser Lys Ser  Ile Ala Gln 
    1055                 1060                 1065             


Val Lys  Lys Val Ile Asn His  His His Met Asn Ile  Val Lys Lys 
    1070                 1075                 1080             


Thr Glu  Ile Gln Lys Gly Gly  Phe Ser Lys Glu Thr  Val Glu Pro 
    1085                 1090                 1095             


Lys Lys  Asp Ser Ser Lys Leu  Leu Pro Arg Lys Asn  Asn Trp Asp 
    1100                 1105                 1110             


Pro Ala  Lys Tyr Gly Gly Leu  Gly Ser Pro Asn Val  Ala Tyr Thr 
    1115                 1120                 1125             


Val Ala  Phe Thr Tyr Glu Lys  Gly Lys Ala Arg Lys  Arg Thr Asn 
    1130                 1135                 1140             


Ala Leu  Glu Gly Ile Thr Ile  Met Glu Arg Glu Ala  Phe Glu Gln 
    1145                 1150                 1155             


Ser Pro  Val Leu Phe Leu Lys  Asn Lys Gly Tyr Glu  Gln Ala Glu 
    1160                 1165                 1170             


Ile Glu  Met Lys Leu Pro Lys  Tyr Ala Leu Phe Glu  Leu Glu Asn 
    1175                 1180                 1185             


Gly Arg  Lys Arg Met Val Ala  Ser Asn Lys Glu Ala  Gln Lys Ala 
    1190                 1195                 1200             


Asn Ser  Phe Leu Leu Pro Glu  His Leu Val Thr Leu  Leu Tyr His 
    1205                 1210                 1215             


Ala Lys  Gln Tyr Asp Glu Ile  Ser His Lys Glu Ser  Phe Asp Tyr 
    1220                 1225                 1230             


Val Asn  Glu His His Lys Glu  Phe Ser Glu Val Phe  Ala Arg Val 
    1235                 1240                 1245             


Leu Glu  Phe Ala Gly Lys Tyr  Thr Leu Ala Glu Lys  Asn Ile Glu 
    1250                 1255                 1260             


Lys Leu  Glu Lys Ile Tyr Lys  Glu Asn Gln Thr Asp  Asp Leu Ala 
    1265                 1270                 1275             


Lys Leu  Ala Ser Ser Phe Val  Asn Leu Met Gln Phe  Asn Ala Met 
    1280                 1285                 1290             


Gly Ala  Pro Ala Asp Phe Lys  Phe Phe Asp Val Thr  Ile Pro Arg 
    1295                 1300                 1305             


Lys Arg  Tyr Thr Ser Leu Thr  Glu Ile Trp Gln Ser  Thr Ile Ile 
    1310                 1315                 1320             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Arg Met Gly 
    1325                 1330                 1335             


Lys 
    


<210>  256
<211>  1340
<212>  PRT
<213>  Enterococcus faecium

<400>  256

Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Pro Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Gly Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Glu Ala Lys Leu Gln Phe Ser 
            260                 265                 270         


Lys Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly 
        275                 280                 285             


Asp Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala 
    290                 295                 300                 


Val Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala 
305                 310                 315                 320 


Lys Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp 
                325                 330                 335     


Leu Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr 
            340                 345                 350         


Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 
        355                 360                 365             


Glu Gly His Ala Thr Gln Glu Ala Phe Tyr Lys Phe Val Lys Lys Glu 
    370                 375                 380                 


Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln 
385                 390                 395                 400 


Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro 
                405                 410                 415     


His Gln Ile His Leu Ser Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys 
            420                 425                 430         


Lys His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu 
        435                 440                 445             


Leu Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln 
    450                 455                 460                 


Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 
465                 470                 475                 480 


Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 
                485                 490                 495     


Arg Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Met Pro His Asn 
            500                 505                 510         


Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr 
        515                 520                 525             


Asn Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn 
    530                 535                 540                 


Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 
545                 550                 555                 560 


Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu 
                565                 570                 575     


Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 
            580                 585                 590         


Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 
        595                 600                 605             


Lys Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 
    610                 615                 620                 


Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 
625                 630                 635                 640 


Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 
                645                 650                 655     


Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Lys Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile 
        675                 680                 685             


Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 
    690                 695                 700                 


Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 
705                 710                 715                 720 


Ile Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 
                725                 730                 735     


Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
            740                 745                 750         


Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 
        755                 760                 765             


Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg 
    770                 775                 780                 


Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 
785                 790                 795                 800 


Lys Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 
                805                 810                 815     


Ser Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
            820                 825                 830         


Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 
        835                 840                 845             


Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 
    850                 855                 860                 


Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 
865                 870                 875                 880 


Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 
                885                 890                 895     


Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 
            900                 905                 910         


Thr Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu 
    930                 935                 940                 


His His Arg Phe Asn Lys Ala Glu Asp Thr Asn Asp Pro Ile Arg Lys 
945                 950                 955                 960 


Val Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn 
                965                 970                 975     


Arg Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Gly Val  Val Ala Leu Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Gln Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Leu Lys 
    1010                 1015                 1020             


Phe Asn  Ala His Lys Ala Asn  Lys Ala Thr Val Lys  Lys Glu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Lys Phe  Phe Glu Ser Asp Thr  Pro Val Cys 
    1040                 1045                 1050             


Asp Glu  Asn Gly Glu Ile Phe  Trp Asp Lys Ser Lys  Ser Ile Ala 
    1055                 1060                 1065             


Gln Val  Lys Lys Val Ile Asn  His His His Met Asn  Ile Val Lys 
    1070                 1075                 1080             


Lys Thr  Glu Ile Gln Lys Gly  Gly Phe Ser Lys Glu  Thr Val Glu 
    1085                 1090                 1095             


Pro Lys  Lys Asp Ser Ser Lys  Leu Leu Pro Arg Lys  Asn Asn Trp 
    1100                 1105                 1110             


Asp Pro  Ala Lys Tyr Gly Gly  Leu Gly Ser Pro Asn  Val Ala Tyr 
    1115                 1120                 1125             


Thr Val  Ala Phe Thr Tyr Glu  Lys Gly Lys Ala Arg  Lys Arg Thr 
    1130                 1135                 1140             


Asn Ala  Leu Glu Gly Ile Thr  Ile Met Glu Arg Glu  Ala Phe Glu 
    1145                 1150                 1155             


Gln Ser  Pro Val Leu Phe Leu  Lys Asn Lys Gly Tyr  Glu Gln Ala 
    1160                 1165                 1170             


Glu Ile  Glu Met Lys Leu Pro  Lys Tyr Ala Leu Phe  Glu Leu Glu 
    1175                 1180                 1185             


Asn Gly  Arg Lys Arg Met Val  Ala Ser Asn Lys Glu  Ala Gln Lys 
    1190                 1195                 1200             


Ala Asn  Ser Phe Leu Leu Pro  Glu His Leu Val Thr  Leu Leu Tyr 
    1205                 1210                 1215             


His Ala  Lys Gln Tyr Asp Glu  Ile Ser His Lys Glu  Ser Phe Asp 
    1220                 1225                 1230             


Tyr Val  Asn Glu His His Lys  Glu Phe Ser Glu Val  Phe Ala Arg 
    1235                 1240                 1245             


Val Leu  Glu Phe Ala Gly Lys  Tyr Thr Leu Ala Glu  Lys Asn Ile 
    1250                 1255                 1260             


Glu Lys  Leu Glu Lys Ile Tyr  Lys Glu Asn Gln Thr  Asp Asp Leu 
    1265                 1270                 1275             


Ala Lys  Leu Ala Ser Ser Phe  Val Asn Leu Met Gln  Phe Asn Ala 
    1280                 1285                 1290             


Met Gly  Ala Pro Ala Asp Phe  Lys Phe Phe Asp Val  Thr Ile Pro 
    1295                 1300                 1305             


Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile Trp Gln  Ser Thr Ile 
    1310                 1315                 1320             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Arg Met 
    1325                 1330                 1335             


Gly Lys  
    1340 


<210>  257
<211>  1340
<212>  PRT
<213>  Enterococcus faecium

<400>  257

Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Asp Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Glu Ala Lys Leu Gln Phe Ser 
            260                 265                 270         


Lys Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly 
        275                 280                 285             


Asp Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala 
    290                 295                 300                 


Val Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala 
305                 310                 315                 320 


Lys Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp 
                325                 330                 335     


Leu Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr 
            340                 345                 350         


Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 
        355                 360                 365             


Glu Gly His Ala Thr Gln Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu 
    370                 375                 380                 


Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln 
385                 390                 395                 400 


Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro 
                405                 410                 415     


His Gln Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys 
            420                 425                 430         


Lys His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu 
        435                 440                 445             


Leu Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln 
    450                 455                 460                 


Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 
465                 470                 475                 480 


Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 
                485                 490                 495     


Arg Phe Ile Glu Arg Met Asn Asn Thr Asp Met Tyr Ile Pro His Asn 
            500                 505                 510         


Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr 
        515                 520                 525             


Asn Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn 
    530                 535                 540                 


Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 
545                 550                 555                 560 


Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu 
                565                 570                 575     


Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 
            580                 585                 590         


Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 
        595                 600                 605             


Lys Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 
    610                 615                 620                 


Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 
625                 630                 635                 640 


Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 
                645                 650                 655     


Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Lys Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile 
        675                 680                 685             


Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 
    690                 695                 700                 


Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 
705                 710                 715                 720 


Ile Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 
                725                 730                 735     


Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
            740                 745                 750         


Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 
        755                 760                 765             


Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg 
    770                 775                 780                 


Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 
785                 790                 795                 800 


Lys Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 
                805                 810                 815     


Ser Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
            820                 825                 830         


Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 
        835                 840                 845             


Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 
    850                 855                 860                 


Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 
865                 870                 875                 880 


Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 
                885                 890                 895     


Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 
            900                 905                 910         


Thr Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu 
    930                 935                 940                 


His His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys 
945                 950                 955                 960 


Val Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn 
                965                 970                 975     


Arg Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Gly Val  Val Ala Leu Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Gln Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Leu Lys 
    1010                 1015                 1020             


Phe Asn  Ala His Lys Ala Asn  Lys Ala Thr Val Lys  Lys Glu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Lys Phe  Phe Glu Ser Asp Thr  Pro Val Cys 
    1040                 1045                 1050             


Asp Glu  Asn Gly Glu Ile Phe  Trp Asp Lys Ser Lys  Ser Ile Ala 
    1055                 1060                 1065             


Gln Val  Lys Lys Val Ile Asn  His His His Met Asn  Ile Val Lys 
    1070                 1075                 1080             


Lys Thr  Glu Ile Gln Lys Gly  Gly Phe Ser Lys Glu  Thr Val Glu 
    1085                 1090                 1095             


Pro Lys  Lys Asp Ser Ser Lys  Leu Leu Pro Arg Lys  Asn Asn Trp 
    1100                 1105                 1110             


Asp Pro  Ala Lys Tyr Gly Gly  Leu Gly Ser Pro Asn  Val Ala Tyr 
    1115                 1120                 1125             


Thr Val  Ala Phe Thr Tyr Glu  Lys Gly Lys Ala Arg  Lys Arg Thr 
    1130                 1135                 1140             


Asn Ala  Leu Glu Gly Ile Thr  Ile Met Glu Arg Glu  Ala Phe Glu 
    1145                 1150                 1155             


Gln Ser  Pro Val Leu Phe Leu  Lys Asn Lys Gly Tyr  Glu Gln Ala 
    1160                 1165                 1170             


Glu Ile  Glu Met Lys Leu Pro  Lys Tyr Ala Leu Phe  Glu Leu Glu 
    1175                 1180                 1185             


Asn Gly  Arg Lys Arg Met Val  Ala Ser Asn Lys Glu  Ala Gln Lys 
    1190                 1195                 1200             


Ala Asn  Ser Phe Leu Leu Pro  Glu His Leu Val Thr  Leu Leu Tyr 
    1205                 1210                 1215             


His Ala  Lys Gln Tyr Asp Glu  Ile Ser His Lys Glu  Ser Phe Asp 
    1220                 1225                 1230             


Tyr Val  Asn Glu His His Lys  Glu Phe Ser Glu Val  Phe Ala Arg 
    1235                 1240                 1245             


Val Leu  Glu Phe Ala Gly Lys  Tyr Thr Leu Ala Glu  Lys Asn Ile 
    1250                 1255                 1260             


Glu Lys  Leu Glu Lys Ile Tyr  Lys Glu Asn Gln Thr  Asp Asp Leu 
    1265                 1270                 1275             


Ala Lys  Leu Ala Ser Ser Phe  Val Asn Leu Met Gln  Phe Asn Ala 
    1280                 1285                 1290             


Met Gly  Ala Pro Ala Asp Phe  Lys Phe Phe Asp Val  Thr Ile Pro 
    1295                 1300                 1305             


Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile Trp Gln  Ser Thr Ile 
    1310                 1315                 1320             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Arg Met 
    1325                 1330                 1335             


Gly Lys  
    1340 


<210>  258
<211>  1340
<212>  PRT
<213>  Enterococcus faecium

<400>  258

Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Asp Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Glu Ala Lys Leu Gln Phe Ser 
            260                 265                 270         


Lys Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly 
        275                 280                 285             


Asp Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala 
    290                 295                 300                 


Val Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala 
305                 310                 315                 320 


Lys Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp 
                325                 330                 335     


Leu Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr 
            340                 345                 350         


Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 
        355                 360                 365             


Glu Gly His Ala Thr Gln Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu 
    370                 375                 380                 


Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln 
385                 390                 395                 400 


Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro 
                405                 410                 415     


His Gln Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys 
            420                 425                 430         


Lys His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu 
        435                 440                 445             


Leu Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln 
    450                 455                 460                 


Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 
465                 470                 475                 480 


Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 
                485                 490                 495     


Arg Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Ile Pro His Asn 
            500                 505                 510         


Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr 
        515                 520                 525             


Asn Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn 
    530                 535                 540                 


Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 
545                 550                 555                 560 


Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu 
                565                 570                 575     


Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 
            580                 585                 590         


Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 
        595                 600                 605             


Lys Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 
    610                 615                 620                 


Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 
625                 630                 635                 640 


Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 
                645                 650                 655     


Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Lys Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile 
        675                 680                 685             


Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 
    690                 695                 700                 


Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 
705                 710                 715                 720 


Ile Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 
                725                 730                 735     


Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
            740                 745                 750         


Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 
        755                 760                 765             


Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg 
    770                 775                 780                 


Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 
785                 790                 795                 800 


Lys Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 
                805                 810                 815     


Ser Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
            820                 825                 830         


Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 
        835                 840                 845             


Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 
    850                 855                 860                 


Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 
865                 870                 875                 880 


Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 
                885                 890                 895     


Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 
            900                 905                 910         


Thr Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu 
    930                 935                 940                 


His His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys 
945                 950                 955                 960 


Val Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn 
                965                 970                 975     


Arg Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Gly Val  Val Ala Leu Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Gln Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Leu Lys 
    1010                 1015                 1020             


Phe Asn  Ala His Lys Ala Asn  Lys Ala Thr Val Lys  Lys Glu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Lys Phe  Phe Glu Ser Asp Thr  Pro Val Cys 
    1040                 1045                 1050             


Asp Glu  Asn Gly Glu Ile Phe  Trp Asp Lys Ser Lys  Ser Ile Ala 
    1055                 1060                 1065             


Gln Val  Lys Lys Val Ile Asn  His His His Met Asn  Ile Val Lys 
    1070                 1075                 1080             


Lys Thr  Glu Ile Gln Lys Gly  Gly Phe Ser Lys Glu  Thr Val Glu 
    1085                 1090                 1095             


Pro Lys  Lys Asp Ser Ser Lys  Leu Leu Pro Arg Lys  Asn Asn Trp 
    1100                 1105                 1110             


Asp Pro  Ala Lys Tyr Gly Gly  Leu Gly Ser Pro Asn  Val Ala Tyr 
    1115                 1120                 1125             


Thr Val  Ala Phe Thr Tyr Glu  Lys Gly Lys Ala Arg  Lys Arg Thr 
    1130                 1135                 1140             


Asn Ala  Leu Glu Gly Ile Thr  Ile Met Glu Arg Glu  Ala Phe Glu 
    1145                 1150                 1155             


Gln Ser  Pro Val Leu Phe Leu  Lys Asn Lys Gly Tyr  Glu Gln Ala 
    1160                 1165                 1170             


Glu Ile  Glu Met Lys Leu Pro  Lys Tyr Ala Leu Phe  Glu Leu Glu 
    1175                 1180                 1185             


Asn Gly  Arg Lys Arg Met Val  Ala Ser Asn Lys Glu  Ala Gln Lys 
    1190                 1195                 1200             


Ala Asn  Ser Phe Leu Leu Pro  Glu His Leu Val Thr  Leu Leu Tyr 
    1205                 1210                 1215             


His Ala  Lys Gln Tyr Asp Glu  Ile Ser His Lys Glu  Ser Phe Asp 
    1220                 1225                 1230             


Tyr Val  Asn Glu His His Lys  Glu Phe Ser Glu Val  Phe Ala Arg 
    1235                 1240                 1245             


Val Leu  Glu Phe Ala Gly Lys  Tyr Thr Leu Ala Glu  Lys Asn Ile 
    1250                 1255                 1260             


Glu Lys  Leu Glu Lys Ile Tyr  Lys Glu Asn Gln Thr  Asp Asp Leu 
    1265                 1270                 1275             


Ala Lys  Leu Ala Ser Ser Phe  Val Asn Leu Met Gln  Phe Asn Ala 
    1280                 1285                 1290             


Met Gly  Ala Pro Ala Asp Phe  Lys Phe Phe Asp Val  Thr Ile Pro 
    1295                 1300                 1305             


Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile Trp Gln  Ser Thr Ile 
    1310                 1315                 1320             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Arg Met 
    1325                 1330                 1335             


Gly Lys  
    1340 


<210>  259
<211>  1339
<212>  PRT
<213>  Enterococcus faecium

<400>  259

Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Asp Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Ala Lys Leu Gln Phe Ser Lys 
            260                 265                 270         


Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly Asp 
        275                 280                 285             


Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala Val 
    290                 295                 300                 


Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala Lys 
305                 310                 315                 320 


Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp Leu 
                325                 330                 335     


Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr Arg 
            340                 345                 350         


Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile Glu 
        355                 360                 365             


Gly His Ala Thr Gln Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu Leu 
    370                 375                 380                 


Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln Glu 
385                 390                 395                 400 


Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro His 
                405                 410                 415     


Gln Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys Lys 
            420                 425                 430         


His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu Leu 
        435                 440                 445             


Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln Glu 
    450                 455                 460                 


Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile Lys 
465                 470                 475                 480 


Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val Arg 
                485                 490                 495     


Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Ile Pro His Asn Lys 
            500                 505                 510         


Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn Tyr 
    530                 535                 540                 


Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu Lys 
545                 550                 555                 560 


Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu Lys 
                565                 570                 575     


Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe Asn 
            580                 585                 590         


Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn Lys 
        595                 600                 605             


Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met Phe 
    610                 615                 620                 


Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met Ile 
625                 630                 635                 640 


Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile Ile 
                645                 650                 655     


Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu Ile 
705                 710                 715                 720 


Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile Val 
                725                 730                 735     


Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro Ala 
        755                 760                 765             


Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg Gly 
    770                 775                 780                 


Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu Lys 
785                 790                 795                 800 


Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser Ser 
                805                 810                 815     


Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp 
            820                 825                 830         


Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile Asp 
    850                 855                 860                 


Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp Asp 
865                 870                 875                 880 


Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr Asp 
                885                 890                 895     


Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu Thr 
            900                 905                 910         


Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu His 
    930                 935                 940                 


His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys Val 
945                 950                 955                 960 


Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn Arg 
                965                 970                 975     


Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Gly Val Val  Ala Leu Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Gln  Leu Ala Pro Glu Phe  Val Tyr Gly Glu Tyr  Leu Lys Phe 
    1010                 1015                 1020             


Asn Ala  His Lys Ala Asn Lys  Ala Thr Val Lys Lys  Glu Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Lys Phe Phe  Glu Ser Asp Thr Pro  Val Cys Asp 
    1040                 1045                 1050             


Glu Asn  Gly Glu Ile Phe Trp  Asp Lys Ser Lys Ser  Ile Ala Gln 
    1055                 1060                 1065             


Val Lys  Lys Val Ile Asn His  His His Met Asn Ile  Val Lys Lys 
    1070                 1075                 1080             


Thr Glu  Ile Gln Lys Gly Gly  Phe Ser Glu Glu Thr  Val Glu Pro 
    1085                 1090                 1095             


Lys Lys  Asp Ser Ser Lys Leu  Leu Pro Arg Lys Asn  Asn Trp Asp 
    1100                 1105                 1110             


Pro Ala  Lys Tyr Gly Gly Leu  Gly Ser Pro Asn Val  Ala Tyr Thr 
    1115                 1120                 1125             


Val Ala  Phe Thr Tyr Glu Lys  Gly Lys Ala Arg Lys  Arg Thr Asn 
    1130                 1135                 1140             


Ala Leu  Glu Gly Ile Thr Ile  Met Glu Arg Glu Ala  Phe Glu Gln 
    1145                 1150                 1155             


Ser Pro  Val Leu Phe Leu Lys  Asn Lys Gly Tyr Glu  Gln Ala Glu 
    1160                 1165                 1170             


Ile Glu  Met Lys Leu Pro Lys  Tyr Ala Leu Phe Glu  Leu Glu Asn 
    1175                 1180                 1185             


Gly Arg  Lys Arg Met Val Ala  Ser Asn Lys Glu Ala  Gln Lys Ala 
    1190                 1195                 1200             


Asn Ser  Phe Leu Leu Pro Glu  His Leu Val Thr Leu  Leu Tyr His 
    1205                 1210                 1215             


Ala Lys  Gln Tyr Asp Glu Ile  Ser His Lys Glu Ser  Phe Asp Tyr 
    1220                 1225                 1230             


Val Asn  Glu His His Lys Glu  Phe Ser Glu Val Phe  Ala Arg Val 
    1235                 1240                 1245             


Leu Glu  Phe Ala Gly Lys Tyr  Thr Leu Ala Glu Lys  Asn Ile Glu 
    1250                 1255                 1260             


Lys Leu  Glu Lys Ile Tyr Lys  Glu Asn Gln Thr Asp  Asp Leu Ala 
    1265                 1270                 1275             


Lys Leu  Ala Ser Ser Phe Val  Asn Leu Met Gln Phe  Asn Ala Met 
    1280                 1285                 1290             


Gly Ala  Pro Ala Asp Phe Lys  Phe Phe Asp Val Thr  Ile Pro Arg 
    1295                 1300                 1305             


Lys Arg  Tyr Thr Ser Leu Thr  Glu Ile Trp Gln Ser  Thr Ile Ile 
    1310                 1315                 1320             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Arg Met Gly 
    1325                 1330                 1335             


Lys 
    


<210>  260
<211>  1340
<212>  PRT
<213>  Enterococcus faecium

<400>  260

Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Asp Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Glu Ala Lys Leu Gln Phe Ser 
            260                 265                 270         


Lys Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly 
        275                 280                 285             


Asp Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala 
    290                 295                 300                 


Val Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala 
305                 310                 315                 320 


Lys Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp 
                325                 330                 335     


Leu Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr 
            340                 345                 350         


Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 
        355                 360                 365             


Glu Gly His Ala Thr Gln Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu 
    370                 375                 380                 


Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln 
385                 390                 395                 400 


Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro 
                405                 410                 415     


His Gln Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys 
            420                 425                 430         


Lys His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu 
        435                 440                 445             


Leu Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln 
    450                 455                 460                 


Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 
465                 470                 475                 480 


Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 
                485                 490                 495     


Arg Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Met Pro His Asn 
            500                 505                 510         


Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr 
        515                 520                 525             


Asn Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn 
    530                 535                 540                 


Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 
545                 550                 555                 560 


Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu 
                565                 570                 575     


Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 
            580                 585                 590         


Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 
        595                 600                 605             


Lys Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 
    610                 615                 620                 


Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 
625                 630                 635                 640 


Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 
                645                 650                 655     


Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Lys Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile 
        675                 680                 685             


Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 
    690                 695                 700                 


Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 
705                 710                 715                 720 


Ile Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 
                725                 730                 735     


Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
            740                 745                 750         


Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 
        755                 760                 765             


Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg 
    770                 775                 780                 


Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 
785                 790                 795                 800 


Lys Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 
                805                 810                 815     


Ser Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
            820                 825                 830         


Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 
        835                 840                 845             


Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 
    850                 855                 860                 


Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 
865                 870                 875                 880 


Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 
                885                 890                 895     


Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 
            900                 905                 910         


Thr Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu 
    930                 935                 940                 


His His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys 
945                 950                 955                 960 


Val Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn 
                965                 970                 975     


Arg Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Gly Val  Val Ala Leu Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Gln Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Leu Lys 
    1010                 1015                 1020             


Phe Asn  Ala His Lys Ala Asn  Lys Ala Thr Val Lys  Lys Glu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Lys Phe  Phe Glu Ser Asp Thr  Pro Val Cys 
    1040                 1045                 1050             


Asp Glu  Asn Gly Glu Ile Phe  Trp Asp Lys Ser Lys  Ser Ile Ala 
    1055                 1060                 1065             


Gln Val  Lys Lys Val Ile Asn  His His His Met Asn  Ile Val Lys 
    1070                 1075                 1080             


Lys Thr  Glu Ile Gln Lys Gly  Gly Phe Ser Lys Glu  Thr Val Glu 
    1085                 1090                 1095             


Pro Lys  Lys Asp Ser Ser Lys  Leu Leu Pro Arg Lys  Asn Asn Trp 
    1100                 1105                 1110             


Asp Pro  Ala Lys Tyr Gly Gly  Leu Gly Ser Pro Asn  Val Ala Tyr 
    1115                 1120                 1125             


Thr Val  Ala Phe Thr Tyr Glu  Lys Gly Lys Ala Arg  Lys Arg Thr 
    1130                 1135                 1140             


Asn Ala  Leu Glu Gly Ile Thr  Ile Met Glu Arg Glu  Ala Phe Glu 
    1145                 1150                 1155             


Gln Ser  Pro Val Leu Phe Leu  Lys Asn Lys Gly Tyr  Glu Gln Ala 
    1160                 1165                 1170             


Glu Ile  Glu Met Lys Leu Pro  Lys Tyr Ala Leu Phe  Glu Leu Glu 
    1175                 1180                 1185             


Asn Gly  Arg Lys Arg Met Val  Ala Ser Asn Lys Glu  Ala Gln Lys 
    1190                 1195                 1200             


Ala Asn  Ser Phe Leu Leu Pro  Glu His Leu Val Thr  Leu Leu Tyr 
    1205                 1210                 1215             


His Ala  Lys Gln Tyr Asp Glu  Ile Ser His Lys Glu  Ser Phe Asp 
    1220                 1225                 1230             


Tyr Val  Asn Glu His His Lys  Glu Phe Ser Glu Val  Phe Ala Arg 
    1235                 1240                 1245             


Val Leu  Glu Phe Ala Gly Lys  Tyr Thr Leu Ala Glu  Lys Asn Ile 
    1250                 1255                 1260             


Glu Lys  Leu Glu Lys Ile Tyr  Lys Glu Asn Gln Thr  Asp Asp Leu 
    1265                 1270                 1275             


Ala Lys  Leu Ala Ser Ser Phe  Val Asn Leu Met Gln  Phe Asn Ala 
    1280                 1285                 1290             


Met Gly  Ala Pro Ala Asp Phe  Lys Phe Phe Asp Val  Thr Ile Pro 
    1295                 1300                 1305             


Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile Trp Gln  Ser Thr Ile 
    1310                 1315                 1320             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Arg Met 
    1325                 1330                 1335             


Gly Lys  
    1340 


<210>  261
<211>  1340
<212>  PRT
<213>  Enterococcus faecium

<400>  261

Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Asp Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Glu Ala Lys Leu Gln Phe Ser 
            260                 265                 270         


Lys Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly 
        275                 280                 285             


Asp Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala 
    290                 295                 300                 


Val Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala 
305                 310                 315                 320 


Lys Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp 
                325                 330                 335     


Leu Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr 
            340                 345                 350         


Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 
        355                 360                 365             


Glu Gly His Ala Thr Gln Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu 
    370                 375                 380                 


Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln 
385                 390                 395                 400 


Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro 
                405                 410                 415     


His Gln Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys 
            420                 425                 430         


Lys His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu 
        435                 440                 445             


Leu Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln 
    450                 455                 460                 


Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 
465                 470                 475                 480 


Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 
                485                 490                 495     


Arg Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Ile Pro His Asn 
            500                 505                 510         


Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr 
        515                 520                 525             


Asn Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn 
    530                 535                 540                 


Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 
545                 550                 555                 560 


Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu 
                565                 570                 575     


Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 
            580                 585                 590         


Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 
        595                 600                 605             


Lys Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 
    610                 615                 620                 


Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 
625                 630                 635                 640 


Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 
                645                 650                 655     


Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Lys Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile 
        675                 680                 685             


Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 
    690                 695                 700                 


Asn Cys Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 
705                 710                 715                 720 


Ile Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 
                725                 730                 735     


Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
            740                 745                 750         


Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 
        755                 760                 765             


Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg 
    770                 775                 780                 


Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 
785                 790                 795                 800 


Lys Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 
                805                 810                 815     


Ser Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
            820                 825                 830         


Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 
        835                 840                 845             


Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 
    850                 855                 860                 


Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 
865                 870                 875                 880 


Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 
                885                 890                 895     


Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 
            900                 905                 910         


Thr Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu 
    930                 935                 940                 


His His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys 
945                 950                 955                 960 


Val Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn 
                965                 970                 975     


Arg Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Gly Val  Val Ala Leu Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Gln Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Leu Lys 
    1010                 1015                 1020             


Phe Asn  Ala His Lys Ala Asn  Lys Ala Thr Val Lys  Lys Glu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Lys Phe  Phe Glu Ser Asp Thr  Pro Val Cys 
    1040                 1045                 1050             


Asp Glu  Asn Gly Glu Ile Phe  Trp Asp Lys Ser Lys  Ser Ile Ala 
    1055                 1060                 1065             


Gln Val  Lys Lys Val Ile Asn  His His His Met Asn  Ile Val Lys 
    1070                 1075                 1080             


Lys Thr  Glu Ile Gln Lys Gly  Gly Phe Ser Lys Glu  Thr Val Glu 
    1085                 1090                 1095             


Pro Lys  Lys Asp Ser Ser Lys  Leu Leu Pro Arg Lys  Asn Asn Trp 
    1100                 1105                 1110             


Asp Pro  Thr Lys Tyr Gly Gly  Leu Gly Ser Pro Asn  Val Ala Tyr 
    1115                 1120                 1125             


Thr Val  Ala Phe Thr Tyr Glu  Lys Gly Lys Ala Arg  Lys Arg Thr 
    1130                 1135                 1140             


Asn Ala  Leu Glu Gly Ile Thr  Ile Met Glu Arg Glu  Ala Phe Glu 
    1145                 1150                 1155             


Gln Ser  Pro Val Leu Phe Leu  Lys Asn Lys Gly Tyr  Glu Gln Ala 
    1160                 1165                 1170             


Glu Ile  Glu Met Lys Leu Pro  Lys Tyr Ala Leu Phe  Glu Leu Glu 
    1175                 1180                 1185             


Asn Gly  Arg Lys Arg Met Val  Ala Ser Asn Lys Glu  Ala Gln Lys 
    1190                 1195                 1200             


Ala Asn  Ser Phe Leu Leu Pro  Glu His Leu Val Thr  Leu Leu Tyr 
    1205                 1210                 1215             


His Ala  Lys Gln Tyr Asp Glu  Ile Ser His Lys Glu  Ser Phe Asp 
    1220                 1225                 1230             


Tyr Val  Asn Glu His His Lys  Glu Phe Ser Glu Val  Phe Ala Arg 
    1235                 1240                 1245             


Val Leu  Glu Phe Ala Gly Lys  Tyr Thr Leu Ala Glu  Lys Asn Ile 
    1250                 1255                 1260             


Glu Lys  Leu Glu Lys Ile Tyr  Lys Glu Asn Gln Thr  Asp Asp Leu 
    1265                 1270                 1275             


Ala Lys  Leu Ala Ser Ser Phe  Val Asn Leu Met Gln  Phe Asn Ala 
    1280                 1285                 1290             


Met Gly  Ala Pro Ala Asp Phe  Lys Phe Phe Asp Val  Thr Ile Pro 
    1295                 1300                 1305             


Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile Trp Gln  Ser Thr Ile 
    1310                 1315                 1320             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Arg Met 
    1325                 1330                 1335             


Gly Lys  
    1340 


<210>  262
<211>  1336
<212>  PRT
<213>  Enterococcus faecium

<400>  262

Met Thr Lys Asp Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Asp Tyr Gln Leu Met Lys Arg Lys Met 
            20                  25                  30          


Ser Val His Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Ala Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Phe Arg Arg Thr 
    50                  55                  60                  


Lys Arg Thr Asn Arg Arg Arg Leu Ala Arg Arg Lys Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Leu Gln Asp Leu Phe Ala Glu Glu Leu Cys Lys Gln Asp Asp Cys 
                85                  90                  95      


Phe Phe Val Arg Leu Glu Glu Ser Phe Leu Val Pro Glu Glu Lys Gln 
            100                 105                 110         


Tyr Lys Pro Ala Ser Ile Phe Pro Thr Leu Glu Glu Glu Lys Glu Tyr 
        115                 120                 125             


Tyr Gln Lys Tyr Pro Thr Ile Tyr His Leu Arg Gln Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Glu Lys Glu Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Phe Glu Gly Asp Leu Asp Thr 
                165                 170                 175     


Glu Asn Thr Ser Ile Glu Glu Ser Phe Arg Val Phe Leu Glu Gln Tyr 
            180                 185                 190         


Ser Lys Gln Ser Asp Gln Pro Leu Ile Val His Gln Pro Val Leu Thr 
        195                 200                 205             


Ile Leu Thr Asp Lys Leu Ser Lys Thr Lys Lys Val Glu Glu Ile Leu 
    210                 215                 220                 


Lys Tyr Tyr Pro Thr Glu Lys Ile Asn Ser Phe Phe Ala Gln Cys Leu 
225                 230                 235                 240 


Lys Leu Ile Val Gly Asn Gln Ala Asn Phe Lys Arg Ile Phe Asp Leu 
                245                 250                 255     


Glu Ala Glu Val Lys Leu Gln Phe Ser Lys Glu Thr Tyr Glu Glu Asp 
            260                 265                 270         


Leu Glu Ser Leu Leu Glu Lys Ile Gly Asp Glu Tyr Leu Asp Ile Phe 
        275                 280                 285             


Leu Gln Ala Lys Lys Val His Asp Ala Ile Leu Leu Ser Glu Ile Ile 
    290                 295                 300                 


Ser Ser Thr Val Lys His Thr Lys Ala Lys Leu Ser Ser Gly Met Val 
305                 310                 315                 320 


Glu Arg Tyr Glu Arg His Lys Ala Asp Leu Ala Lys Phe Lys Gln Phe 
                325                 330                 335     


Val Lys Glu Asn Val Pro Gln Lys Ala Thr Val Phe Phe Lys Asp Thr 
            340                 345                 350         


Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Lys Gly Lys Thr Thr Gln Glu 
        355                 360                 365             


Glu Phe Tyr Lys Phe Val Lys Lys Glu Leu Ser Gly Val Val Gly Ser 
    370                 375                 380                 


Glu Pro Phe Leu Glu Lys Ile Asp Gln Glu Thr Phe Leu Leu Lys Gln 
385                 390                 395                 400 


Arg Thr Tyr Thr Asn Gly Val Ile Pro His Gln Val His Leu Ile Glu 
                405                 410                 415     


Leu Lys Ala Ile Ile Asp Gln Gln Lys Gln His Tyr Pro Phe Leu Glu 
            420                 425                 430         


Glu Ala Gly Pro Lys Ile Ile Ala Leu Phe Lys Phe Arg Ile Pro Tyr 
        435                 440                 445             


Tyr Val Gly Pro Leu Ala Lys Glu Gln Glu Ala Ser Ser Phe Ala Trp 
    450                 455                 460                 


Ile Glu Arg Lys Thr Ala Glu Lys Ile Asn Pro Trp Asn Phe Ser Glu 
465                 470                 475                 480 


Val Val Asp Ile Glu Lys Ser Ala Met Arg Phe Ile Gln Arg Met Thr 
                485                 490                 495     


Lys Gln Asp Thr Tyr Leu Pro Thr Glu Lys Val Leu Pro Lys Asn Ser 
            500                 505                 510         


Leu Leu Tyr Gln Lys Tyr Met Ile Phe Asn Glu Leu Thr Lys Val Ser 
        515                 520                 525             


Tyr Lys Asp Glu Arg Gly Val Lys Gln Tyr Phe Ser Gly Asp Glu Lys 
    530                 535                 540                 


Gln Gln Ile Phe Lys Gln Leu Phe Gln Lys Glu Arg Gly Lys Ile Thr 
545                 550                 555                 560 


Val Lys Lys Leu Gln Asn Phe Leu Tyr Thr His Tyr His Ile Glu Asn 
                565                 570                 575     


Ala Gln Ile Phe Gly Ile Glu Lys Ala Phe Asn Ala Ser Tyr Ser Thr 
            580                 585                 590         


Tyr His Asp Phe Met Lys Leu Ala Lys Thr Asn Gln Lys Ala Met Gln 
        595                 600                 605             


Glu Trp Leu Glu Gln Pro Glu Met Glu Pro Ile Phe Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Met Ile Lys His Gln Leu 
625                 630                 635                 640 


Ser Lys Tyr Gln Glu Val Phe Gly Glu Lys Leu Leu Lys Glu Phe Ala 
                645                 650                 655     


Arg Lys His Tyr Thr Gly Trp Gly Arg Phe Ser Ala Lys Leu Ile His 
            660                 665                 670         


Gly Ile Arg Asp Arg Lys Thr Asn Lys Thr Ile Leu Asp Tyr Leu Ile 
        675                 680                 685             


Asn Asp Asp Asp Val Pro Ala Asn Arg Asn Arg Asn Leu Met Gln Leu 
    690                 695                 700                 


Ile Asn Asp Glu His Leu Ser Phe Lys Glu Glu Ile Ala Lys Ala Thr 
705                 710                 715                 720 


Val Phe Ser Lys His Lys Ser Leu Val Asp Val Ile Gln Asp Leu Pro 
                725                 730                 735     


Gly Ser Pro Ala Ile Lys Lys Gly Ile Trp Gln Ser Leu Lys Ile Val 
            740                 745                 750         


Glu Glu Leu Ile Ala Ile Ile Gly Tyr Lys Pro Lys Asn Ile Val Ile 
        755                 760                 765             


Glu Met Ala Arg Glu Asn Gln Lys Thr His Arg Thr Ser Pro Arg Leu 
    770                 775                 780                 


Lys Ala Leu Glu Asn Gly Leu Lys Gln Ile Gly Ser Thr Leu Leu Lys 
785                 790                 795                 800 


Glu Gln Pro Thr Asp Asn Lys Ala Leu Gln Lys Glu Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Pro Leu Glu 
            820                 825                 830         


Ile Glu Asn Leu His Gln Tyr Glu Val Asp His Ile Ile Pro Arg Ser 
        835                 840                 845             


Phe Ile Val Asp Asn Ser Ile Asp Asp Lys Val Leu Val Ala Ser Lys 
    850                 855                 860                 


Gln Asn Gln Lys Lys Arg Asp Asp Val Pro Lys Lys Gln Ile Val Asn 
865                 870                 875                 880 


Glu Gln Arg Ile Phe Trp Asn Gln Leu Lys Glu Ala Lys Leu Ile Ser 
                885                 890                 895     


Thr Lys Lys Tyr Ala Tyr Leu Thr Lys Ile Glu Leu Thr Pro Glu Asp 
            900                 905                 910         


Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Asn Ile Leu His Gln Ser Phe Asn Gln Glu Glu Glu 
    930                 935                 940                 


Gly Thr Asp Cys Asp Gly Val Gln Ile Ile Thr Leu Lys Ala Thr Leu 
945                 950                 955                 960 


Thr Ser Gln Phe Arg Gln Thr Phe Gly Leu Tyr Lys Val Arg Glu Ile 
                965                 970                 975     


Asn Pro His His His Ala His Asp Ala Tyr Leu Asn Gly Phe Ile Ala 
            980                 985                 990         


Asn Val Leu Leu Lys Arg Tyr Pro  Lys Leu Ala Pro Glu  Phe Val Tyr 
        995                 1000                 1005             


Gly Lys  Tyr Val Lys Tyr Ser  Leu Ala Arg Glu Asn  Lys Ala Thr 
    1010                 1015                 1020             


Ala Lys  Lys Glu Phe Tyr Ser  Asn Ile Leu Lys Phe  Leu Glu Ser 
    1025                 1030                 1035             


Asp Glu  Pro Phe Cys Asp Glu  Asn Gly Glu Ile Tyr  Trp Glu Lys 
    1040                 1045                 1050             


Ser His  His Leu Pro Arg Ile  Lys Lys Val Leu Ser  Ser His Gln 
    1055                 1060                 1065             


Val Asn  Val Val Lys Lys Val  Glu Gln Gln Lys Gly  Gly Phe Tyr 
    1070                 1075                 1080             


Lys Glu  Thr Val Asn Ser Lys  Glu Lys Pro Asp Lys  Leu Ile Glu 
    1085                 1090                 1095             


Arg Lys  Asn Asn Trp Asp Val  Thr Lys Tyr Gly Gly  Phe Gly Ser 
    1100                 1105                 1110             


Pro Val  Ile Ala Tyr Ala Ile  Ala Phe Val Tyr Ala  Lys Gly Lys 
    1115                 1120                 1125             


Thr Gln  Lys Lys Thr Arg Ala  Ile Glu Gly Ile Thr  Ile Met Glu 
    1130                 1135                 1140             


Gln Ala  Ala Phe Glu Lys Asp  Pro Thr Thr Phe Leu  Lys Glu Lys 
    1145                 1150                 1155             


Gly Phe  Pro Gln Val Thr Glu  Phe Ile Lys Leu Pro  Lys Tyr Thr 
    1160                 1165                 1170             


Leu Phe  Glu Phe Asp Asn Gly  Arg Arg Arg Phe Leu  Ala Ser His 
    1175                 1180                 1185             


Lys Glu  Ser Gln Lys Gly Asn  Pro Phe Ile Leu Ser  Asp Gln Leu 
    1190                 1195                 1200             


Val Thr  Leu Leu Tyr His Ala  Gln His Tyr Asp Lys  Ile Thr Tyr 
    1205                 1210                 1215             


Gln Glu  Ser Phe Asp Tyr Val  Asn Thr His Leu Ser  Asp Phe Ser 
    1220                 1225                 1230             


Ala Ile  Leu Thr Glu Val Leu  Ala Phe Ala Glu Lys  Tyr Thr Leu 
    1235                 1240                 1245             


Ala Asp  Lys Asn Ile Glu Arg  Ile Gln Glu Leu Tyr  Glu Glu Asn 
    1250                 1255                 1260             


Lys Tyr  Gly Glu Thr Ser Met  Ile Ala Gln Ser Phe  Leu Gln Leu 
    1265                 1270                 1275             


Leu Gln  Phe Asn Ala Ile Gly  Ala Pro Ala Asp Phe  Lys Phe Phe 
    1280                 1285                 1290             


Gly Val  Thr Ile Pro Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile 
    1295                 1300                 1305             


Trp Asp  Ala Thr Ile Ile Tyr  Gln Ser Val Thr Gly  Leu Tyr Glu 
    1310                 1315                 1320             


Thr Arg  Ile Arg Met Gly Asp  Leu Trp Ala Gly Glu  Gln 
    1325                 1330                 1335     


<210>  263
<211>  1340
<212>  PRT
<213>  Enterococcus faecium

<400>  263

Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Asp Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Glu Ala Lys Leu Gln Phe Ser 
            260                 265                 270         


Lys Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly 
        275                 280                 285             


Asp Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala 
    290                 295                 300                 


Val Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala 
305                 310                 315                 320 


Lys Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp 
                325                 330                 335     


Leu Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr 
            340                 345                 350         


Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 
        355                 360                 365             


Glu Gly His Ala Thr Gln Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu 
    370                 375                 380                 


Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln 
385                 390                 395                 400 


Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro 
                405                 410                 415     


His Gln Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys 
            420                 425                 430         


Lys His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu 
        435                 440                 445             


Leu Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln 
    450                 455                 460                 


Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 
465                 470                 475                 480 


Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 
                485                 490                 495     


Arg Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Met Pro His Asn 
            500                 505                 510         


Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr 
        515                 520                 525             


Asn Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn 
    530                 535                 540                 


Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 
545                 550                 555                 560 


Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu 
                565                 570                 575     


Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 
            580                 585                 590         


Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 
        595                 600                 605             


Lys Arg Glu Met Glu Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 
    610                 615                 620                 


Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 
625                 630                 635                 640 


Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 
                645                 650                 655     


Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Lys Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile 
        675                 680                 685             


Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 
    690                 695                 700                 


Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 
705                 710                 715                 720 


Ile Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 
                725                 730                 735     


Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
            740                 745                 750         


Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 
        755                 760                 765             


Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg 
    770                 775                 780                 


Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 
785                 790                 795                 800 


Lys Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 
                805                 810                 815     


Ser Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
            820                 825                 830         


Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 
        835                 840                 845             


Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 
    850                 855                 860                 


Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 
865                 870                 875                 880 


Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 
                885                 890                 895     


Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 
            900                 905                 910         


Thr Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu 
    930                 935                 940                 


His His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys 
945                 950                 955                 960 


Val Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn 
                965                 970                 975     


Arg Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Gly Val  Ile Ala Leu Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Gln Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Leu Lys 
    1010                 1015                 1020             


Phe Asn  Ala His Lys Ala Asn  Lys Ala Thr Val Lys  Lys Glu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Lys Phe  Phe Glu Ser Asp Thr  Pro Val Cys 
    1040                 1045                 1050             


Asp Glu  Asn Gly Glu Ile Phe  Trp Asp Lys Ser Lys  Ser Ile Ala 
    1055                 1060                 1065             


Gln Val  Lys Lys Val Ile Asn  His His His Met Asn  Ile Val Lys 
    1070                 1075                 1080             


Lys Thr  Glu Ile Gln Lys Gly  Gly Phe Ser Lys Glu  Thr Val Glu 
    1085                 1090                 1095             


Pro Lys  Lys Asp Ser Ser Lys  Leu Leu Pro Arg Lys  Asn Asn Trp 
    1100                 1105                 1110             


Asp Pro  Ala Lys Tyr Gly Gly  Leu Gly Ser Pro Asn  Val Ala Tyr 
    1115                 1120                 1125             


Thr Val  Ala Phe Thr Tyr Glu  Lys Gly Lys Ala Arg  Lys Arg Thr 
    1130                 1135                 1140             


Asn Ala  Leu Glu Gly Ile Thr  Ile Met Glu Arg Glu  Ala Phe Glu 
    1145                 1150                 1155             


Gln Ser  Pro Val Leu Phe Leu  Lys Asn Lys Gly Tyr  Glu Gln Ala 
    1160                 1165                 1170             


Glu Ile  Glu Met Lys Leu Pro  Lys Tyr Ala Leu Phe  Glu Leu Glu 
    1175                 1180                 1185             


Asn Gly  Arg Lys Arg Met Val  Ala Ser Asn Lys Glu  Ala Gln Lys 
    1190                 1195                 1200             


Ala Asn  Ser Phe Leu Leu Pro  Glu His Leu Val Thr  Leu Leu Tyr 
    1205                 1210                 1215             


His Ala  Lys Gln Tyr Asp Glu  Ile Ser His Lys Glu  Ser Phe Asp 
    1220                 1225                 1230             


Tyr Val  Asn Glu His His Lys  Glu Phe Ser Glu Val  Phe Ala Arg 
    1235                 1240                 1245             


Val Leu  Glu Phe Ala Gly Lys  Tyr Thr Leu Ala Glu  Lys Asn Ile 
    1250                 1255                 1260             


Glu Lys  Leu Glu Lys Ile Tyr  Lys Glu Asn Gln Thr  Asp Asp Leu 
    1265                 1270                 1275             


Ala Lys  Leu Ala Ser Ser Phe  Val Asn Leu Met Gln  Phe Asn Ala 
    1280                 1285                 1290             


Met Gly  Ala Pro Ala Asp Phe  Lys Phe Phe Asp Val  Thr Ile Pro 
    1295                 1300                 1305             


Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile Trp Gln  Ser Thr Ile 
    1310                 1315                 1320             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Arg Met 
    1325                 1330                 1335             


Gly Lys  
    1340 


<210>  264
<211>  1336
<212>  PRT
<213>  Enterococcus hirae

<400>  264

Met Thr Lys Asp Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Asp Tyr Gln Leu Met Lys Arg Lys Met 
            20                  25                  30          


Ser Val His Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Ala Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Phe Arg Arg Thr 
    50                  55                  60                  


Lys Arg Thr Asn Arg Arg Arg Leu Ala Arg Arg Lys Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Leu Gln Asp Leu Phe Ala Glu Glu Leu Cys Lys Gln Asp Asp Cys 
                85                  90                  95      


Phe Phe Val Arg Leu Glu Glu Ser Phe Leu Val Pro Glu Glu Lys Gln 
            100                 105                 110         


Tyr Lys Pro Ala Ser Ile Phe Pro Thr Leu Glu Glu Glu Lys Glu Tyr 
        115                 120                 125             


Tyr Gln Lys Tyr Pro Thr Ile Tyr His Leu Arg Gln Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Glu Lys Gly Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Phe Glu Gly Asp Leu Asp Thr 
                165                 170                 175     


Glu Asn Thr Ser Ile Glu Glu Ser Phe Arg Val Phe Leu Glu Gln Tyr 
            180                 185                 190         


Gly Lys Gln Ser Asp Gln Pro Leu Ile Val His Gln Pro Val Leu Thr 
        195                 200                 205             


Ile Leu Thr Asp Lys Leu Ser Lys Thr Lys Lys Val Glu Glu Ile Leu 
    210                 215                 220                 


Lys Tyr Tyr Pro Thr Glu Lys Ile Asn Ser Phe Phe Ala Gln Cys Leu 
225                 230                 235                 240 


Lys Leu Ile Val Gly Asn Gln Ala Asn Phe Lys Arg Ile Phe Asp Leu 
                245                 250                 255     


Glu Ala Glu Val Lys Leu Gln Phe Ser Lys Glu Thr Tyr Glu Glu Asp 
            260                 265                 270         


Leu Glu Ser Leu Leu Glu Lys Ile Gly Asp Glu Tyr Leu Asp Ile Phe 
        275                 280                 285             


Leu Gln Ala Lys Lys Val His Asp Ala Ile Leu Leu Ser Glu Ile Ile 
    290                 295                 300                 


Ser Ser Thr Val Lys His Thr Gln Ala Lys Leu Ser Ser Gly Met Val 
305                 310                 315                 320 


Glu Arg Tyr Glu Arg His Lys Ala Asp Leu Ala Lys Phe Lys Gln Phe 
                325                 330                 335     


Val Lys Glu Asn Val Pro Gln Lys Ala Thr Val Phe Phe Lys Asp Thr 
            340                 345                 350         


Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Lys Gly Lys Thr Thr Gln Glu 
        355                 360                 365             


Glu Phe Tyr Lys Phe Val Lys Lys Glu Leu Ser Gly Val Val Gly Ser 
    370                 375                 380                 


Glu Pro Phe Leu Glu Lys Ile Asp Gln Glu Thr Phe Leu Leu Lys Gln 
385                 390                 395                 400 


Arg Thr Tyr Thr Asn Gly Val Ile Pro His Gln Val His Leu Ile Glu 
                405                 410                 415     


Leu Lys Ala Ile Ile Asp Gln Gln Lys Gln His Tyr Pro Phe Leu Glu 
            420                 425                 430         


Glu Ala Gly Pro Lys Ile Ile Ala Leu Phe Lys Phe Arg Ile Pro Tyr 
        435                 440                 445             


Tyr Val Gly Pro Leu Ala Lys Glu Gln Glu Ala Ser Ser Phe Ala Trp 
    450                 455                 460                 


Ile Glu Arg Lys Thr Ala Glu Lys Ile Asn Pro Trp Asn Phe Ser Glu 
465                 470                 475                 480 


Val Val Asp Ile Glu Lys Ser Ala Met Arg Phe Ile Gln Arg Met Thr 
                485                 490                 495     


Lys Gln Asp Thr Tyr Leu Pro Thr Glu Lys Val Leu Pro Lys Asn Ser 
            500                 505                 510         


Leu Phe Tyr Gln Lys Tyr Met Ile Phe Asn Glu Leu Thr Lys Val Ser 
        515                 520                 525             


Tyr Lys Asp Glu Arg Gly Val Lys Gln Tyr Phe Ser Gly Asp Glu Lys 
    530                 535                 540                 


Gln Gln Ile Phe Lys Gln Leu Phe Gln Lys Glu Arg Gly Lys Ile Thr 
545                 550                 555                 560 


Val Lys Lys Leu Gln Asn Phe Leu Tyr Thr His Tyr His Ile Glu Asn 
                565                 570                 575     


Ala Gln Ile Phe Gly Ile Glu Lys Ala Phe Asn Ala Ser Tyr Ser Thr 
            580                 585                 590         


Tyr His Asp Phe Met Lys Leu Ala Lys Thr Asn Gln Lys Ala Met Gln 
        595                 600                 605             


Glu Trp Leu Glu Gln Pro Glu Met Glu Pro Ile Phe Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Met Ile Lys His Gln Leu 
625                 630                 635                 640 


Ser Lys Tyr Gln Glu Val Phe Gly Glu Lys Leu Leu Lys Glu Phe Ala 
                645                 650                 655     


Arg Lys His Tyr Thr Gly Trp Gly Arg Phe Ser Ala Lys Leu Ile His 
            660                 665                 670         


Gly Ile Arg Asp Arg Lys Thr Asn Lys Thr Ile Leu Asp Tyr Leu Ile 
        675                 680                 685             


Asn Asp Asp Asp Val Pro Ala Asn Arg Asn Arg Asn Leu Met Gln Leu 
    690                 695                 700                 


Ile Asn Asp Glu His Leu Ser Phe Lys Glu Glu Ile Ala Lys Ala Thr 
705                 710                 715                 720 


Val Phe Ser Lys His Lys Ser Leu Val Asp Val Ile Gln Asp Leu Pro 
                725                 730                 735     


Gly Ser Pro Ala Ile Lys Lys Gly Ile Trp Gln Ser Leu Lys Ile Val 
            740                 745                 750         


Glu Glu Leu Ile Ala Ile Ile Gly Tyr Lys Pro Lys Asn Ile Val Ile 
        755                 760                 765             


Glu Met Ala Arg Glu Asn Gln Lys Thr His Arg Thr Lys Pro Arg Leu 
    770                 775                 780                 


Lys Ala Leu Glu Asn Gly Leu Lys Gln Ile Gly Ser Thr Leu Leu Lys 
785                 790                 795                 800 


Glu Gln Pro Thr Asp Asn Lys Ala Leu Gln Lys Glu Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Pro Leu Glu 
            820                 825                 830         


Ile Glu Asn Leu His Gln Tyr Glu Val Asp His Ile Ile Pro Arg Ser 
        835                 840                 845             


Phe Ile Val Asp Asn Ser Ile Asp Asn Lys Val Leu Val Ala Ser Lys 
    850                 855                 860                 


Gln Asn Gln Lys Lys Arg Asp Asp Val Pro Lys Lys Gln Ile Val Asn 
865                 870                 875                 880 


Glu Gln Arg Ile Phe Trp Asn Gln Leu Lys Glu Ala Lys Leu Ile Ser 
                885                 890                 895     


Pro Lys Lys Tyr Ala Tyr Leu Thr Lys Ile Glu Leu Thr Pro Glu Asp 
            900                 905                 910         


Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Asn Ile Leu His Gln Ser Phe Asn Gln Glu Glu Glu 
    930                 935                 940                 


Gly Thr Asp Cys Asp Gly Val Gln Ile Ile Thr Leu Lys Ala Thr Leu 
945                 950                 955                 960 


Thr Ser Gln Phe Arg Gln Thr Phe Gly Leu Tyr Lys Val Arg Glu Ile 
                965                 970                 975     


Asn Pro His His His Ala His Asp Ala Tyr Leu Asn Gly Phe Ile Ala 
            980                 985                 990         


Asn Val Leu Leu Lys Arg Tyr Pro  Lys Leu Ala Pro Glu  Phe Val Tyr 
        995                 1000                 1005             


Gly Lys  Tyr Val Lys Tyr Ser  Leu Ala Arg Glu Asn  Lys Ala Thr 
    1010                 1015                 1020             


Ala Lys  Lys Glu Phe Tyr Ser  Asn Ile Leu Lys Phe  Leu Glu Ser 
    1025                 1030                 1035             


Asp Glu  Pro Phe Cys Asp Glu  Asn Gly Glu Ile Tyr  Trp Glu Lys 
    1040                 1045                 1050             


Ser His  His Leu Pro Arg Ile  Lys Lys Val Leu Ser  Ser His Gln 
    1055                 1060                 1065             


Val Asn  Val Val Lys Lys Val  Glu Gln Gln Lys Gly  Gly Phe Tyr 
    1070                 1075                 1080             


Lys Glu  Thr Val Asn Ser Lys  Glu Lys Pro Asp Lys  Leu Ile Glu 
    1085                 1090                 1095             


Arg Lys  Asn Asn Trp Asp Val  Thr Lys Tyr Gly Gly  Phe Gly Ser 
    1100                 1105                 1110             


Pro Val  Ile Ala Tyr Ala Ile  Ala Phe Val Tyr Ala  Lys Gly Lys 
    1115                 1120                 1125             


Thr Gln  Lys Lys Thr Lys Ala  Ile Glu Gly Ile Thr  Ile Met Glu 
    1130                 1135                 1140             


Gln Ala  Ala Phe Glu Lys Asp  Pro Thr Thr Phe Leu  Lys Asp Lys 
    1145                 1150                 1155             


Gly Phe  Pro Gln Val Thr Glu  Phe Ile Lys Leu Pro  Lys Tyr Thr 
    1160                 1165                 1170             


Leu Phe  Glu Phe Asp Asn Gly  Arg Arg Arg Phe Leu  Ala Ser His 
    1175                 1180                 1185             


Lys Glu  Ser Gln Lys Gly Asn  Pro Phe Ile Leu Ser  Asp Gln Leu 
    1190                 1195                 1200             


Val Thr  Leu Leu Tyr His Ala  Gln His Tyr Asp Lys  Ile Thr Tyr 
    1205                 1210                 1215             


Gln Glu  Ser Phe Asp Tyr Val  Asn Thr His Leu Ser  Asp Phe Ser 
    1220                 1225                 1230             


Ala Ile  Leu Thr Glu Val Leu  Ala Phe Ala Glu Lys  Tyr Thr Leu 
    1235                 1240                 1245             


Ala Asp  Lys Asn Ile Glu Arg  Ile Gln Glu Leu Tyr  Glu Glu Asn 
    1250                 1255                 1260             


Lys Tyr  Gly Glu Ile Ser Met  Ile Ala Gln Ser Phe  Leu Gln Leu 
    1265                 1270                 1275             


Leu Gln  Phe Asn Ala Ile Gly  Ala Pro Ala Asp Phe  Lys Phe Phe 
    1280                 1285                 1290             


Gly Val  Thr Ile Pro Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile 
    1295                 1300                 1305             


Trp Asp  Ala Thr Ile Ile Tyr  Gln Ser Val Thr Gly  Leu Tyr Glu 
    1310                 1315                 1320             


Thr Arg  Ile Arg Met Gly Asp  Leu Trp Ala Gly Glu  Gln 
    1325                 1330                 1335     


<210>  265
<211>  1336
<212>  PRT
<213>  Enterococcus hirae

<400>  265

Met Thr Lys Asp Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Asp Tyr Gln Leu Met Lys Arg Lys Met 
            20                  25                  30          


Ser Val His Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Ala Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Phe Arg Arg Thr 
    50                  55                  60                  


Lys Arg Thr Asn Arg Arg Arg Leu Ala Arg Arg Lys Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Leu Gln Asp Leu Phe Ala Glu Glu Leu Cys Lys Gln Asp Asp Cys 
                85                  90                  95      


Phe Phe Val Arg Leu Glu Glu Ser Phe Leu Val Pro Glu Glu Lys Gln 
            100                 105                 110         


Tyr Lys Pro Ala Ser Ile Phe Pro Thr Leu Glu Glu Glu Lys Glu Tyr 
        115                 120                 125             


Tyr Gln Lys Tyr Pro Thr Ile Tyr His Leu Arg Gln Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Glu Lys Glu Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Phe Glu Gly Asp Leu Asp Thr 
                165                 170                 175     


Glu Asn Thr Ser Ile Glu Glu Ser Phe Arg Val Phe Leu Glu Gln Tyr 
            180                 185                 190         


Ser Lys Gln Ser Asp Gln Pro Leu Ile Val His Gln Pro Val Leu Thr 
        195                 200                 205             


Ile Leu Thr Asp Lys Leu Ser Lys Thr Lys Lys Val Glu Glu Ile Leu 
    210                 215                 220                 


Lys Tyr Tyr Pro Thr Glu Lys Ile Asn Ser Phe Phe Ala Gln Cys Leu 
225                 230                 235                 240 


Lys Leu Ile Val Gly Asn Gln Ala Asn Phe Lys Arg Ile Phe Asp Leu 
                245                 250                 255     


Glu Ala Glu Val Lys Leu Gln Phe Ser Lys Glu Thr Tyr Glu Glu Asp 
            260                 265                 270         


Leu Glu Ser Leu Leu Glu Lys Ile Gly Asp Glu Tyr Leu Asp Ile Phe 
        275                 280                 285             


Leu Gln Ala Lys Lys Val His Asp Ala Ile Leu Leu Ser Glu Ile Ile 
    290                 295                 300                 


Ser Ser Thr Val Lys His Thr Lys Ala Lys Leu Ser Ser Gly Met Val 
305                 310                 315                 320 


Glu Arg Tyr Glu Arg His Lys Ala Asp Leu Ala Lys Phe Lys Gln Phe 
                325                 330                 335     


Val Lys Glu Asn Val Pro Gln Lys Ala Thr Val Phe Phe Lys Asp Thr 
            340                 345                 350         


Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Lys Gly Lys Thr Thr Gln Glu 
        355                 360                 365             


Glu Phe Tyr Lys Phe Val Lys Lys Glu Leu Ser Gly Val Val Gly Ser 
    370                 375                 380                 


Glu Pro Phe Leu Glu Lys Ile Asp Gln Glu Thr Phe Leu Leu Lys Gln 
385                 390                 395                 400 


Arg Thr Tyr Thr Asn Gly Val Ile Pro His Gln Val His Leu Ile Glu 
                405                 410                 415     


Leu Lys Ala Ile Ile Asp Gln Gln Lys Gln His Tyr Pro Phe Leu Glu 
            420                 425                 430         


Glu Ala Gly Pro Lys Ile Ile Ala Leu Phe Lys Phe Arg Ile Pro Tyr 
        435                 440                 445             


Tyr Val Gly Pro Leu Ala Lys Glu Gln Glu Ala Ser Ser Phe Ala Trp 
    450                 455                 460                 


Ile Glu Arg Lys Thr Ala Glu Lys Ile Asn Pro Trp Asn Phe Ser Glu 
465                 470                 475                 480 


Val Val Asp Ile Glu Lys Ser Ala Met Arg Phe Ile Gln Arg Met Thr 
                485                 490                 495     


Lys Gln Asp Thr Tyr Leu Pro Thr Glu Lys Val Leu Pro Lys Asn Ser 
            500                 505                 510         


Leu Leu Tyr Gln Lys Tyr Met Ile Phe Asn Glu Leu Thr Lys Val Ser 
        515                 520                 525             


Tyr Lys Asp Glu Arg Gly Val Lys Gln Tyr Phe Ser Gly Asp Glu Lys 
    530                 535                 540                 


Gln Gln Ile Phe Lys Gln Leu Phe Gln Lys Glu Arg Gly Lys Ile Thr 
545                 550                 555                 560 


Val Lys Lys Leu Gln Asn Phe Leu Tyr Thr His Tyr His Ile Glu Asn 
                565                 570                 575     


Ala Gln Ile Phe Gly Ile Glu Lys Ala Phe Asn Ala Ser Tyr Ser Thr 
            580                 585                 590         


Tyr His Asp Phe Met Lys Leu Ala Lys Thr Asn Gln Lys Ala Met Gln 
        595                 600                 605             


Glu Trp Leu Glu Gln Pro Glu Met Glu Pro Ile Phe Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Met Ile Lys His Gln Leu 
625                 630                 635                 640 


Ser Lys Tyr Gln Glu Val Phe Gly Glu Lys Leu Leu Lys Glu Phe Ala 
                645                 650                 655     


Arg Lys His Tyr Thr Gly Trp Gly Arg Phe Ser Ala Lys Leu Ile His 
            660                 665                 670         


Gly Ile Arg Asp Arg Lys Thr Asn Lys Thr Ile Leu Asp Tyr Leu Ile 
        675                 680                 685             


Asn Asp Asp Asp Val Pro Ala Asn Arg Asn Arg Asn Leu Met Gln Leu 
    690                 695                 700                 


Ile Asn Asp Glu His Leu Ser Phe Lys Glu Glu Ile Ala Lys Ala Thr 
705                 710                 715                 720 


Val Phe Ser Lys His Lys Ser Leu Val Asp Val Ile Gln Asp Leu Pro 
                725                 730                 735     


Gly Ser Pro Ala Ile Lys Lys Gly Ile Trp Gln Ser Leu Lys Ile Val 
            740                 745                 750         


Glu Glu Leu Ile Ala Ile Ile Gly Tyr Lys Pro Lys Asn Ile Val Ile 
        755                 760                 765             


Glu Met Ala Arg Glu Asn Gln Lys Thr His Arg Thr Ser Pro Arg Leu 
    770                 775                 780                 


Lys Ala Leu Glu Asn Gly Leu Lys Gln Ile Gly Ser Thr Leu Leu Lys 
785                 790                 795                 800 


Glu Gln Pro Thr Asp Asn Lys Ala Leu Gln Lys Glu Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Pro Leu Glu 
            820                 825                 830         


Ile Glu Asn Leu His Gln Tyr Glu Val Asp His Ile Ile Pro Arg Ser 
        835                 840                 845             


Phe Ile Val Asp Asn Ser Ile Asp Asn Lys Val Leu Val Ala Ser Lys 
    850                 855                 860                 


Gln Asn Gln Lys Lys Arg Asp Asp Val Pro Lys Lys Gln Ile Val Asn 
865                 870                 875                 880 


Glu Gln Arg Ile Phe Trp Asn Gln Leu Lys Glu Ala Lys Leu Ile Ser 
                885                 890                 895     


Pro Lys Lys Tyr Ala Tyr Leu Thr Lys Ile Glu Leu Thr Pro Glu Asp 
            900                 905                 910         


Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Asn Ile Leu His Gln Ser Phe Asn Gln Glu Glu Glu 
    930                 935                 940                 


Gly Thr Asp Cys Asp Gly Val Gln Ile Ile Thr Leu Lys Ala Thr Leu 
945                 950                 955                 960 


Thr Ser Gln Phe Arg Gln Thr Phe Gly Leu Tyr Lys Val Arg Glu Ile 
                965                 970                 975     


Asn Pro His His His Ala His Asp Ala Tyr Leu Asn Gly Phe Ile Ala 
            980                 985                 990         


Asn Val Leu Leu Lys Arg Tyr Pro  Lys Leu Ala Pro Glu  Phe Val Tyr 
        995                 1000                 1005             


Gly Lys  Tyr Val Lys Tyr Ser  Leu Ala Arg Glu Asn  Lys Ala Thr 
    1010                 1015                 1020             


Ala Lys  Lys Glu Phe Tyr Ser  Asn Ile Leu Lys Phe  Leu Glu Ser 
    1025                 1030                 1035             


Asp Glu  Pro Phe Cys Asp Glu  Asn Gly Glu Ile Tyr  Trp Glu Lys 
    1040                 1045                 1050             


Ser His  His Leu Pro Arg Ile  Lys Lys Val Leu Ser  Ser His Gln 
    1055                 1060                 1065             


Val Asn  Val Val Lys Lys Val  Glu Gln Gln Lys Gly  Gly Phe Tyr 
    1070                 1075                 1080             


Lys Glu  Thr Val Asn Ser Lys  Glu Lys Pro Asp Lys  Leu Ile Glu 
    1085                 1090                 1095             


Arg Lys  Asn Asn Trp Asp Val  Thr Lys Tyr Gly Gly  Phe Gly Ser 
    1100                 1105                 1110             


Pro Val  Ile Ala Tyr Ala Ile  Ala Phe Val Tyr Ala  Lys Gly Lys 
    1115                 1120                 1125             


Thr Gln  Lys Lys Thr Arg Ala  Ile Glu Gly Ile Thr  Ile Met Glu 
    1130                 1135                 1140             


Gln Ala  Ala Phe Glu Lys Asp  Pro Thr Thr Phe Leu  Lys Glu Lys 
    1145                 1150                 1155             


Gly Phe  Pro Gln Val Thr Glu  Phe Ile Lys Leu Pro  Lys Tyr Thr 
    1160                 1165                 1170             


Leu Phe  Glu Phe Asp Asn Gly  Arg Arg Arg Phe Leu  Ala Ser His 
    1175                 1180                 1185             


Lys Glu  Ser Gln Lys Gly Asn  Pro Phe Ile Leu Ser  Asp Gln Leu 
    1190                 1195                 1200             


Val Thr  Leu Leu Tyr His Ala  Gln His Tyr Asp Lys  Ile Thr Tyr 
    1205                 1210                 1215             


Gln Glu  Ser Phe Asp Tyr Val  Asn Thr His Leu Ser  Asp Phe Ser 
    1220                 1225                 1230             


Ala Ile  Leu Thr Glu Val Leu  Ala Phe Ala Glu Lys  Tyr Thr Leu 
    1235                 1240                 1245             


Ala Asp  Lys Asn Ile Glu Arg  Ile Gln Glu Leu Tyr  Glu Glu Asn 
    1250                 1255                 1260             


Lys Tyr  Gly Glu Thr Ser Met  Ile Ala Gln Ser Phe  Leu Gln Leu 
    1265                 1270                 1275             


Leu Gln  Phe Asn Ala Ile Gly  Ala Pro Ala Asp Phe  Lys Phe Phe 
    1280                 1285                 1290             


Gly Val  Thr Ile Pro Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile 
    1295                 1300                 1305             


Trp Asp  Ala Thr Ile Ile Tyr  Gln Ser Val Thr Gly  Leu Tyr Glu 
    1310                 1315                 1320             


Thr Arg  Ile Arg Met Gly Asp  Leu Trp Ala Gly Glu  Gln 
    1325                 1330                 1335     


<210>  266
<211>  1336
<212>  PRT
<213>  Enterococcus hirae

<400>  266

Met Thr Lys Asp Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Asp Tyr Gln Leu Met Lys Arg Lys Met 
            20                  25                  30          


Ser Val His Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Ala Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Phe Arg Arg Thr 
    50                  55                  60                  


Lys Arg Thr Asn Arg Arg Arg Leu Ala Arg Arg Lys Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Leu Gln Asp Leu Phe Ala Glu Glu Leu Cys Lys Gln Asp Asp Cys 
                85                  90                  95      


Phe Phe Val Arg Leu Glu Glu Ser Phe Leu Val Pro Glu Glu Lys Gln 
            100                 105                 110         


Tyr Lys Pro Ala Ser Ile Phe Pro Thr Leu Glu Glu Glu Lys Glu Tyr 
        115                 120                 125             


Tyr Gln Lys Tyr Pro Thr Ile Tyr His Leu Arg Gln Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Glu Lys Glu Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Phe Glu Gly Asp Leu Asp Thr 
                165                 170                 175     


Glu Asn Thr Ser Ile Glu Glu Ser Phe Arg Val Phe Leu Glu Gln Tyr 
            180                 185                 190         


Gly Lys Gln Ser Asp Gln Pro Leu Ile Val His Gln Pro Val Leu Thr 
        195                 200                 205             


Ile Leu Thr Asp Lys Leu Ser Lys Thr Lys Lys Val Glu Glu Ile Leu 
    210                 215                 220                 


Lys Tyr Tyr Pro Thr Glu Lys Ile Asn Ser Phe Phe Ala Gln Cys Leu 
225                 230                 235                 240 


Lys Leu Ile Val Gly Asn Gln Ala Asn Phe Lys Arg Ile Phe Asp Leu 
                245                 250                 255     


Glu Ala Glu Val Lys Leu Gln Phe Ser Lys Glu Thr Tyr Glu Glu Asp 
            260                 265                 270         


Leu Glu Ser Leu Leu Glu Lys Ile Gly Asp Glu Tyr Leu Asp Ile Phe 
        275                 280                 285             


Leu Gln Ala Lys Lys Val His Asp Ala Ile Leu Leu Ser Glu Ile Ile 
    290                 295                 300                 


Ser Ser Thr Val Lys His Thr Gln Ala Lys Leu Ser Ser Gly Met Val 
305                 310                 315                 320 


Glu Arg Tyr Glu Arg His Lys Ala Asp Leu Ala Lys Phe Lys Gln Phe 
                325                 330                 335     


Val Lys Glu Asn Val Pro Gln Lys Ala Thr Val Phe Phe Lys Asp Thr 
            340                 345                 350         


Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Lys Gly Lys Thr Thr Gln Glu 
        355                 360                 365             


Glu Phe Tyr Lys Phe Val Lys Lys Glu Leu Ser Gly Val Val Gly Ser 
    370                 375                 380                 


Glu Pro Phe Leu Glu Lys Ile Asp Gln Glu Thr Phe Leu Leu Lys Gln 
385                 390                 395                 400 


Arg Thr Tyr Thr Asn Gly Val Ile Pro His Gln Val His Leu Ile Glu 
                405                 410                 415     


Leu Lys Ala Ile Ile Asp Gln Gln Lys Gln His Tyr Pro Phe Leu Glu 
            420                 425                 430         


Glu Ala Gly Pro Lys Ile Ile Ala Leu Phe Lys Phe Arg Ile Pro Tyr 
        435                 440                 445             


Tyr Val Gly Pro Leu Ala Lys Glu Gln Glu Ala Ser Ser Phe Ala Trp 
    450                 455                 460                 


Ile Glu Arg Lys Thr Ala Glu Lys Ile Asn Pro Trp Asn Phe Ser Glu 
465                 470                 475                 480 


Val Val Asp Ile Glu Lys Ser Ala Met Arg Phe Ile Gln Arg Met Thr 
                485                 490                 495     


Lys Gln Asp Thr Tyr Leu Pro Thr Glu Lys Val Leu Pro Lys Asn Ser 
            500                 505                 510         


Leu Leu Tyr Gln Lys Tyr Met Ile Phe Asn Glu Leu Thr Lys Val Ser 
        515                 520                 525             


Tyr Lys Asp Glu Arg Gly Val Lys Gln Tyr Phe Ser Gly Asp Glu Lys 
    530                 535                 540                 


Gln Gln Ile Phe Lys Gln Leu Phe Gln Lys Glu Arg Gly Lys Ile Thr 
545                 550                 555                 560 


Val Lys Lys Leu Gln Asn Phe Leu Tyr Thr His Tyr His Ile Glu Asn 
                565                 570                 575     


Ala Gln Ile Phe Gly Ile Glu Lys Ala Phe Asn Ala Ser Tyr Ser Thr 
            580                 585                 590         


Tyr His Asp Phe Met Lys Leu Ala Lys Thr Asn Gln Lys Ala Met Gln 
        595                 600                 605             


Glu Trp Leu Glu Gln Pro Glu Met Glu Pro Ile Phe Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Met Ile Lys His Gln Leu 
625                 630                 635                 640 


Ser Lys Tyr Gln Glu Val Phe Gly Glu Lys Leu Leu Lys Glu Phe Ala 
                645                 650                 655     


Arg Lys His Tyr Thr Gly Trp Gly Arg Phe Ser Ala Lys Leu Ile His 
            660                 665                 670         


Gly Ile Arg Asp Arg Lys Thr Asn Lys Thr Ile Leu Asp Tyr Leu Ile 
        675                 680                 685             


Asn Asp Asp Asp Val Pro Ala Asn Arg Asn Arg Asn Leu Met Gln Leu 
    690                 695                 700                 


Ile Asn Asp Glu His Leu Ser Phe Lys Glu Glu Ile Ala Lys Ala Thr 
705                 710                 715                 720 


Val Phe Ser Lys His Lys Ser Leu Val Asp Val Ile Gln Asp Leu Pro 
                725                 730                 735     


Gly Ser Pro Ala Ile Lys Lys Gly Ile Trp Gln Ser Leu Lys Ile Val 
            740                 745                 750         


Glu Glu Leu Ile Ala Ile Ile Gly Tyr Lys Pro Lys Asn Ile Val Ile 
        755                 760                 765             


Glu Met Ala Arg Glu Asn Gln Lys Thr His Arg Thr Lys Pro Arg Leu 
    770                 775                 780                 


Lys Ala Leu Glu Asn Gly Leu Lys Gln Ile Gly Ser Thr Leu Leu Lys 
785                 790                 795                 800 


Glu Gln Pro Thr Asp Asn Lys Ala Leu Gln Lys Glu Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Pro Leu Glu 
            820                 825                 830         


Ile Glu Asn Leu His Gln Tyr Glu Val Asp His Ile Ile Pro Arg Ser 
        835                 840                 845             


Phe Ile Val Asp Asn Ser Ile Asp Asn Lys Val Leu Val Ala Ser Lys 
    850                 855                 860                 


Gln Asn Gln Lys Lys Arg Asp Asp Val Pro Asn Lys Gln Ile Val Asn 
865                 870                 875                 880 


Glu Gln Arg Ile Phe Trp Asn Gln Leu Lys Glu Ala Lys Leu Ile Ser 
                885                 890                 895     


Pro Lys Lys Tyr Ala Tyr Leu Thr Lys Ile Glu Leu Thr Pro Glu Asp 
            900                 905                 910         


Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Asn Ile Leu His Gln Ser Phe Asn Gln Glu Glu Glu 
    930                 935                 940                 


Gly Thr Asp Cys Asp Gly Val Gln Ile Ile Thr Leu Lys Ala Thr Leu 
945                 950                 955                 960 


Thr Ser Gln Phe Arg Gln Thr Phe Gly Leu Tyr Lys Val Arg Glu Ile 
                965                 970                 975     


Asn Pro His His His Ala His Asp Ala Tyr Leu Asn Gly Phe Ile Ala 
            980                 985                 990         


Asn Val Leu Leu Lys Arg Tyr Pro  Lys Leu Ala Pro Glu  Phe Val Tyr 
        995                 1000                 1005             


Gly Lys  Tyr Val Lys Tyr Ser  Leu Ala Arg Glu Asn  Lys Ala Thr 
    1010                 1015                 1020             


Ala Lys  Lys Glu Phe Tyr Ser  Asn Ile Leu Lys Phe  Leu Glu Ser 
    1025                 1030                 1035             


Asp Glu  Pro Phe Cys Asp Glu  Asn Gly Glu Ile Tyr  Trp Glu Lys 
    1040                 1045                 1050             


Ser His  His Leu Pro Arg Ile  Lys Lys Val Leu Ser  Ser His Gln 
    1055                 1060                 1065             


Val Asn  Val Val Lys Lys Val  Glu Gln Gln Lys Gly  Gly Phe Tyr 
    1070                 1075                 1080             


Lys Glu  Thr Val Asn Ser Lys  Glu Lys Pro Asp Lys  Leu Ile Glu 
    1085                 1090                 1095             


Arg Lys  Asn Asn Trp Asp Val  Thr Lys Tyr Gly Gly  Phe Gly Ser 
    1100                 1105                 1110             


Pro Val  Ile Ala Tyr Ala Ile  Ala Phe Val Tyr Ala  Lys Gly Lys 
    1115                 1120                 1125             


Thr Gln  Lys Lys Thr Arg Ala  Ile Glu Gly Ile Thr  Ile Met Glu 
    1130                 1135                 1140             


Gln Ala  Ala Phe Glu Lys Asp  Pro Thr Thr Phe Leu  Lys Asp Lys 
    1145                 1150                 1155             


Gly Phe  Pro His Val Thr Glu  Phe Ile Lys Leu Pro  Lys Tyr Thr 
    1160                 1165                 1170             


Leu Phe  Glu Phe Asp Asn Gly  Arg Arg Arg Phe Leu  Ala Ser His 
    1175                 1180                 1185             


Lys Glu  Ser Gln Lys Gly Asn  Pro Phe Ile Leu Ser  Asp Gln Leu 
    1190                 1195                 1200             


Val Thr  Leu Leu Tyr His Ala  Gln His Tyr Asp Lys  Ile Thr Tyr 
    1205                 1210                 1215             


Gln Glu  Ser Phe Asp Tyr Val  Asn Thr His Leu Ser  Asp Phe Ser 
    1220                 1225                 1230             


Ala Ile  Leu Thr Glu Val Leu  Ala Phe Ala Glu Lys  Tyr Thr Leu 
    1235                 1240                 1245             


Ala Asp  Lys Asn Ile Glu Arg  Ile Gln Glu Leu Tyr  Glu Glu Asn 
    1250                 1255                 1260             


Lys Tyr  Gly Glu Ile Ser Met  Ile Ala Gln Ser Phe  Leu Gln Leu 
    1265                 1270                 1275             


Leu Gln  Phe Asn Ala Ile Gly  Ala Pro Ala Asp Phe  Lys Phe Phe 
    1280                 1285                 1290             


Gly Val  Thr Ile Pro Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile 
    1295                 1300                 1305             


Trp Asp  Ala Thr Ile Ile Tyr  Gln Ser Val Thr Gly  Leu Tyr Glu 
    1310                 1315                 1320             


Thr Arg  Ile Arg Met Gly Asp  Leu Trp Ala Gly Glu  Gln 
    1325                 1330                 1335     


<210>  267
<211>  1330
<212>  PRT
<213>  Enterococcus italicus

<400>  267

Met Lys Asn Asp Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ser Val Val Thr Asp Asp Tyr Lys Val Ile Ser Lys Lys Met 
            20                  25                  30          


Asn Val Phe Gly Asn Thr Glu Lys Lys Ser Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Ser Gly Gln Thr Ala Gln Glu Ala Arg Met 
    50                  55                  60                  


Lys Arg Thr Ser Arg Arg Arg Ile Ala Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Gln Pro Glu Met Asn His Leu Asp Asn Asn 
                85                  90                  95      


Phe Phe Tyr Arg Leu Asn Glu Ser Phe Leu Val Ala Asp Asp Ala Lys 
            100                 105                 110         


Tyr Asp Lys His Pro Ile Phe Gly Thr Leu Asp Glu Glu Ile His Phe 
        115                 120                 125             


His Glu Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Gly Asp Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Ile Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly Asn Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Asn Ser Val Ile Glu Leu Ser Lys Val Phe Val Gln Leu Tyr 
            180                 185                 190         


Asn Gln Thr Leu Ser Glu Leu Glu Gly Phe Gln Phe Ile Asp Glu Ser 
        195                 200                 205             


Ile Asp Phe Ser Glu Val Leu Thr Gln Gln Leu Ser Lys Ser Glu Arg 
    210                 215                 220                 


Ala Asp Asn Val Leu Lys Leu Phe Pro Asp Glu Lys Gly Thr Gly Ile 
225                 230                 235                 240 


Phe Ala Gln Phe Ile Lys Leu Ile Val Gly Asn Gln Gly Asn Phe Lys 
                245                 250                 255     


Lys Val Phe Gln Leu Glu Glu Asp Gln Lys Leu Gln Leu Ser Thr Asp 
            260                 265                 270         


Asp Tyr Glu Glu Asn Ile Glu Asn Leu Leu Ala Ile Ile Gly Asp Glu 
        275                 280                 285             


Tyr Gly Asp Ile Phe Val Ala Ala Gln Asn Leu Tyr Gln Ala Ile Leu 
    290                 295                 300                 


Leu Ala Gly Ile Leu Thr Ser Thr Glu Lys Thr Arg Ala Lys Leu Ser 
305                 310                 315                 320 


Ala Ser Met Ile Gln Arg Tyr Glu Glu His Ala Lys Asp Leu Lys Leu 
                325                 330                 335     


Leu Lys Arg Phe Val Lys Glu His Ile Pro Asp Lys Tyr Ala Glu Ile 
            340                 345                 350         


Phe Asn Asp Ala Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys 
        355                 360                 365             


Thr Lys Glu Glu Glu Phe Tyr Lys Tyr Leu Lys Thr Thr Leu Val Gln 
    370                 375                 380                 


Lys Ser Gly Tyr Gln Tyr Phe Ile Glu Lys Ile Glu Gln Glu Asn Phe 
385                 390                 395                 400 


Leu Arg Lys Gln Arg Ile Tyr Asp Asn Gly Val Ile Pro His Gln Val 
                405                 410                 415     


His Ala Glu Glu Leu Arg Ala Ile Leu Arg Lys Gln Glu Lys Tyr Tyr 
            420                 425                 430         


Ser Phe Leu Lys Glu Asn His Glu Lys Ile Glu Gln Ile Phe Lys Val 
        435                 440                 445             


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys His Asn Glu Gln Ser 
    450                 455                 460                 


Arg Phe Ala Trp Asn Ile Arg Lys Ser Asp Glu Pro Ile Arg Pro Trp 
465                 470                 475                 480 


Asn Met Asn Asp Val Val Asp Glu Asn Ala Ser Ala Val Ala Phe Ile 
                485                 490                 495     


Glu Arg Met Thr Ile Lys Asp Ile Tyr Leu Asn Glu Asn Val Leu Pro 
            500                 505                 510         


Arg His Ser Leu Ile Tyr Glu Lys Phe Thr Val Phe Asn Glu Leu Thr 
        515                 520                 525             


Lys Val Leu Tyr Ala Asp Asp Arg Gly Val Phe Gln Arg Phe Ser Ala 
    530                 535                 540                 


Glu Glu Lys Glu Asp Ile Phe Glu Lys Leu Phe Lys Ser Glu Arg Lys 
545                 550                 555                 560 


Val Thr Lys Lys Lys Leu Glu Asn Tyr Leu Arg Ile Glu Leu Ser Ile 
                565                 570                 575     


Ser Ser Pro Ser Val Lys Gly Ile Glu Glu Gln Phe Asn Ala Asn Phe 
            580                 585                 590         


Gly Thr Tyr Leu Asp Leu Lys Lys Phe Asp Glu Leu His Pro Tyr Leu 
        595                 600                 605             


Asp Asp Glu Lys Tyr Gln Asp Thr Leu Glu Glu Val Ile Lys Val Leu 
    610                 615                 620                 


Thr Val Phe Glu Asp Arg Ser Met Ile Gln Asn Gln Leu Glu Gln Leu 
625                 630                 635                 640 


Pro Leu Asn Leu Ser Thr Lys Thr Ile Lys Ala Leu Ser Arg Arg Lys 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Arg Leu Ile Asp Gly Ile His 
            660                 665                 670         


Asp Lys Asn Ser Gly Lys Thr Ile Leu Asp Tyr Leu Ile Glu Asp Glu 
        675                 680                 685             


Ser Asp Ser Tyr Ile Val Asn Arg Asn Phe Met Gln Leu Ile Asn Asp 
    690                 695                 700                 


Asp His Leu Ser Phe Lys Lys Ile Ile Glu Asp Ser Gln Pro Tyr Lys 
705                 710                 715                 720 


Glu Gln Gln Ser Ala Glu Glu Ile Val Ser Glu Leu Ser Gly Ser Pro 
                725                 730                 735     


Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu 
            740                 745                 750         


Val Ala Ile Met Gly Tyr Lys Pro Lys Asn Ile Val Val Glu Met Ala 
        755                 760                 765             


Arg Glu Asn Gln Thr Thr Gly Arg Gly Lys Gln Asn Ser Lys Pro Arg 
    770                 775                 780                 


Leu Lys Gly Ile Glu Asn Gly Leu Lys Glu Phe Ser Asp Ser Val Leu 
785                 790                 795                 800 


Lys Gly Ser Ser Ile Asp Asn Lys Gln Leu Gln Asn Asp Arg Leu Tyr 
                805                 810                 815     


Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly His Glu Leu 
            820                 825                 830         


Asp Ile Asp His Leu Ser Thr Tyr Asp Ile Asp His Ile Ile Pro Gln 
        835                 840                 845             


Ser Phe Leu Thr Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Thr Ser 
    850                 855                 860                 


Lys Ser Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val 
865                 870                 875                 880 


Arg Lys Met Asp Arg Phe Trp Arg Lys Leu Leu Asn Ala Lys Leu Ile 
                885                 890                 895     


Ser Glu Arg Lys Tyr Thr Asn Leu Thr Lys Lys Glu Leu Thr Glu Ser 
            900                 905                 910         


Asp Lys Ala Gly Phe Leu Lys Arg Gln Leu Val Glu Thr Arg Gln Ile 
        915                 920                 925             


Thr Lys His Val Ala Thr Ile Leu Asp Ser Lys Phe Asn Glu Asp Ser 
    930                 935                 940                 


Asn Asn Arg Asp Val Gln Ile Ile Thr Leu Lys Ser Ala Leu Val Ser 
945                 950                 955                 960 


Glu Phe Arg Lys Thr Phe Asn Leu Tyr Lys Val Arg Glu Ile Asn Asp 
                965                 970                 975     


Leu His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Ala Leu Ser 
            980                 985                 990         


Leu Leu Arg Val Tyr Pro Gln Leu  Lys Pro Glu Phe Val  Tyr Gly Glu 
        995                 1000                 1005             


Tyr Gly  Lys Asn Ser Ile His  Asp Gln Asn Lys Ala  Thr Ile Lys 
    1010                 1015                 1020             


Lys Gln  Phe Tyr Ser Asn Ile  Thr Arg Tyr Phe Ala  Ser Lys Asp 
    1025                 1030                 1035             


Tyr Ile  Ile Asn Asp Asp Gly  Glu Ile Leu Trp Asn  Lys Gln Glu 
    1040                 1045                 1050             


Thr Ile  Ala Gln Val Ile Lys  Thr Leu Gly Met His  Gln Val Asn 
    1055                 1060                 1065             


Val Val  Lys Lys Val Glu Ile  Gln Lys Gly Gly Phe  Ser Lys Glu 
    1070                 1075                 1080             


Ser Ile  Gln Pro Lys Gly Glu  Ser Gln Lys Leu Ile  Arg Arg Lys 
    1085                 1090                 1095             


Gln Gln  Trp Asn Thr Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Val 
    1100                 1105                 1110             


Val Ala  Tyr Ala Ile Leu Leu  Ser Phe Asp Lys Gly  Lys Arg Lys 
    1115                 1120                 1125             


Ala Arg  Ser Phe Lys Ile Val  Gly Ile Thr Ile Gln  Asp Arg Glu 
    1130                 1135                 1140             


Ser Phe  Glu Gly Asn Pro Ile  Leu Tyr Leu Ser Lys  Lys Asp Tyr 
    1145                 1150                 1155             


His Asn  Pro Lys Val Glu Ala  Ile Leu Pro Lys Tyr  Ser Leu Phe 
    1160                 1165                 1170             


Glu Phe  Glu Asn Gly Arg Arg  Arg Met Val Ala Ser  Ala Ser Glu 
    1175                 1180                 1185             


Thr Gln  Lys Gly Asn Gln Leu  Ile Ile Pro Gly His  Leu Met Glu 
    1190                 1195                 1200             


Leu Leu  Tyr His Ser Lys Lys  Ile Ile Asn Gly Lys  Asn Ser Asp 
    1205                 1210                 1215             


Ser Val  Ser Tyr Ile Gln Asn  Asn Lys Glu Lys Phe  Arg Glu Ile 
    1220                 1225                 1230             


Phe Glu  Tyr Ile Val Asp Phe  Ser Ser Lys Tyr Ile  Ser Ala Asp 
    1235                 1240                 1245             


Ala Asn  Leu Asn Lys Ile Glu  Lys Ile Phe Glu Asn  Asn Phe His 
    1250                 1255                 1260             


Lys Ala  Ser Glu Gln Glu Ile  Ala Lys Ser Phe Ile  Asn Leu Leu 
    1265                 1270                 1275             


Thr Phe  Thr Ala Met Gly Ala  Pro Ala Asp Phe Glu  Phe Phe Gly 
    1280                 1285                 1290             


Glu Lys  Ile Pro Arg Lys Arg  Tyr Val Ser Ile Ser  Glu Ile Ile 
    1295                 1300                 1305             


Asp Ala  Val Phe Ile His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr 
    1310                 1315                 1320             


Arg Val  Arg Leu Thr Glu Val  
    1325                 1330 


<210>  268
<211>  1330
<212>  PRT
<213>  Enterococcus mundtii

<400>  268

Met Glu Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Asp Tyr Arg Leu Val Ala Arg Lys Met 
            20                  25                  30          


Ser Ile Gln Gly Asp Ser Asn Arg Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Ala Arg Leu Phe Glu Glu Gly Lys Thr Ala Gln Phe Arg Arg Ile 
    50                  55                  60                  


Lys Arg Thr Asn Arg Arg Arg Ile Ala Arg Arg Arg Gln Arg Val Leu 
65                  70                  75                  80  


Ala Leu Gln Asp Ile Phe Ala Glu Glu Ile His Lys Lys Asp Pro Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Glu Glu Gly Asp Arg Val Glu Ala Asp Lys Arg 
            100                 105                 110         


Phe Ala Lys Phe Pro Val Phe Ala Thr Leu Ser Glu Glu Lys Asn Tyr 
        115                 120                 125             


His Arg Gln Tyr Pro Thr Ile Tyr His Leu Arg His Asp Leu Ala Asn 
    130                 135                 140                 


Ser Lys Glu Gln Ala Asp Ile Arg Leu Val Tyr Leu Ala Ile Ala His 
145                 150                 155                 160 


Cys Leu Lys Tyr Arg Gly His Phe Leu Phe Glu Gly Glu Leu Asp Thr 
                165                 170                 175     


Glu Asn Thr Ser Val Thr Glu Asn Tyr Gln Gln Phe Leu Gln Ala Tyr 
            180                 185                 190         


Gln Gln Phe Phe Pro Glu Pro Ile Gly Asp Leu Asp Asp Ala Val Pro 
        195                 200                 205             


Ile Leu Thr Glu Arg Leu Ser Lys Ala Lys Arg Val Glu Lys Val Leu 
    210                 215                 220                 


Ala Tyr Tyr Pro Ser Glu Lys Ser Thr Gly Asn Phe Ala Gln Phe Leu 
225                 230                 235                 240 


Lys Leu Met Val Gly Asn Gln Ala Asn Phe Lys Lys Thr Phe Asp Leu 
                245                 250                 255     


Glu Glu Glu Met Lys Leu Asn Phe Thr Arg Asp Cys Tyr Glu Glu Asp 
            260                 265                 270         


Leu Asn Glu Leu Leu Glu Lys Thr Ser Asp Asp Tyr Ala Glu Leu Phe 
        275                 280                 285             


Leu Lys Ala Lys Gly Val Tyr Asp Ala Ile Leu Leu Ser Gln Ile Leu 
    290                 295                 300                 


Ser Lys Ser Asp Asp Glu Thr Lys Ala Lys Leu Ser Ala Asn Met Lys 
305                 310                 315                 320 


Leu Arg Phe Glu Glu His Gln Arg Asp Leu Lys Gln Leu Lys Glu Leu 
                325                 330                 335     


Val Arg Arg Asp Leu Pro Lys Lys Tyr Asp Asp Phe Phe Lys Asn Arg 
            340                 345                 350         


Ser Lys Asn Gly Tyr Ala Gly Tyr Val Lys Gly Lys Ala Thr Gln Glu 
        355                 360                 365             


Asp Phe Tyr Lys Phe Leu Arg Thr Glu Leu Ala Gly Leu Glu Glu Ser 
    370                 375                 380                 


Gln Ser Ile Met Glu Lys Ile Asp Leu Glu Ile Tyr Leu Leu Lys Gln 
385                 390                 395                 400 


Arg Thr Phe Ala Asn Gly Val Ile Pro His Gln Ile His Leu Val Glu 
                405                 410                 415     


Met Arg Glu Ile Met Asp Arg Gln Lys Arg Phe Tyr Pro Phe Leu Lys 
            420                 425                 430         


Gly Ala Gln Gly Lys Ile Glu Lys Leu Leu Thr Phe Arg Ile Pro Tyr 
        435                 440                 445             


Tyr Val Gly Pro Leu Ala Gln Glu Gly Gln Ser Pro Phe Ala Trp Ile 
    450                 455                 460                 


Lys Arg Lys Ser Pro Ser Gln Ile Thr Pro Trp Asn Phe Ala Glu Val 
465                 470                 475                 480 


Val Asp Lys Glu Asn Ser Ala Ile Glu Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Gln Asp Thr Tyr Leu Pro Lys Glu Lys Val Leu Pro Lys Gln Ser Leu 
            500                 505                 510         


Ile Tyr Gln Arg Phe Met Ile Phe Asn Glu Leu Thr Lys Val Ser Tyr 
        515                 520                 525             


Thr Asp Glu Arg Gly Lys Ser His Tyr Phe Ser Ser Glu Gln Lys Arg 
    530                 535                 540                 


Lys Ile Phe Asn Glu Leu Phe Lys Gln His Pro Arg Val Thr Glu Lys 
545                 550                 555                 560 


Gln Leu Arg Lys Phe Leu Glu Leu Asn Glu Gln Ile Asp Ser Thr Glu 
                565                 570                 575     


Ile Lys Gly Ile Glu Thr Ser Phe Asn Ala Ser Tyr Ser Thr Tyr His 
            580                 585                 590         


Asp Leu Leu Lys Leu Ser Asp Gln Met Asp Thr Leu Leu Asp Asp Pro 
        595                 600                 605             


Asp Met Thr Thr Met Phe Glu Glu Ile Ile Lys Ile Leu Thr Ile Phe 
    610                 615                 620                 


Glu Asp Arg Glu Met Ile Arg Glu Gln Leu Lys Pro Tyr Glu Thr Val 
625                 630                 635                 640 


Leu Gly Leu Pro Ala Ile Lys Lys Leu Ala Lys Lys His Tyr Thr Gly 
                645                 650                 655     


Trp Gly Arg Leu Ser Glu Lys Met Ile Gln Gly Met Arg Glu Lys Gln 
            660                 665                 670         


Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Asp Asp Phe Pro 
        675                 680                 685             


Cys Asn Arg Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp His Leu 
    690                 695                 700                 


Ser Phe Lys Glu Thr Ile Ala Asn Glu Leu Ile Met Ser Asp Ser Asn 
705                 710                 715                 720 


Val Leu Leu Asp Gln Val Lys Ala Ile Pro Gly Ser Pro Ala Val Lys 
                725                 730                 735     


Lys Gly Ile Trp Gln Ser Ile Lys Ile Val Glu Glu Ile Ile Gly Ile 
            740                 745                 750         


Ile Gly Lys Ala Pro Lys Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Arg Thr Ser Arg Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ala 
    770                 775                 780                 


Leu Lys Asn Ile Asp Ser Pro Leu Leu Lys Asp Tyr Pro Thr Asp Asn 
785                 790                 795                 800 


Gln Ala Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly 
                805                 810                 815     


Lys Asp Met Tyr Thr Gly Glu Pro Leu Glu Ile His Arg Leu Ser Glu 
            820                 825                 830         


Tyr Asp Ile Asp His Ile Ile Pro Arg Ser Phe Ile Val Asp Asn Ser 
        835                 840                 845             


Leu Asp Asn Lys Val Leu Val Ser Ser Lys Val Asn Arg Gly Lys Leu 
    850                 855                 860                 


Asp Asn Ala Pro Asp Pro Leu Val Val Lys Arg Met Arg Ser His Trp 
865                 870                 875                 880 


Glu Lys Leu His Gln Ala Lys Leu Ile Ser Asp Lys Lys Leu Ala Asn 
                885                 890                 895     


Leu Thr Lys Gln Asn Leu Thr Glu Ala Asp Lys Ala Arg Phe Ile Gln 
            900                 905                 910         


Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Asn Leu 
        915                 920                 925             


Leu His Gln His Phe Asn Leu Pro Glu Glu Val Ser Ala Thr Glu Lys 
    930                 935                 940                 


Thr Ser Ile Ile Thr Leu Lys Ser Thr Leu Thr Ser Gln Phe Arg Gln 
945                 950                 955                 960 


Met Phe Asp Ile Tyr Lys Val Arg Glu Ile Asn His His His His Ala 
                965                 970                 975     


His Asp Ala Tyr Leu Asn Gly Val Val Ala Met Thr Leu Leu Lys Lys 
            980                 985                 990         


Tyr Pro Lys Leu Ala Pro Glu Phe  Val Tyr Gly Ser Tyr  Ile Lys Gly 
        995                 1000                 1005             


Asp Ile  Asn Gln Ile Asn Lys  Ala Thr Ala Lys Lys  Glu Phe Tyr 
    1010                 1015                 1020             


Ser Asn  Ile Met Lys Phe Phe  Glu Ser Glu Glu Ile  Ile Cys Asp 
    1025                 1030                 1035             


Glu Gln  Gly Glu Val Ile Trp  Asn Lys Lys Arg Asp  Leu Ser Thr 
    1040                 1045                 1050             


Ile Lys  Lys Thr Ile Gly Ala  His Gln Val Asn Ile  Val Lys Lys 
    1055                 1060                 1065             


Val Glu  Lys Gln Lys Gly Gly  Phe Tyr Lys Glu Thr  Ile Asn Ser 
    1070                 1075                 1080             


Lys Ala  Asn Pro Glu Lys Leu  Ile Pro Arg Lys Ala  Ser Leu Asp 
    1085                 1090                 1095             


Pro Leu  Lys Tyr Gly Gly Tyr  Gly Ser Pro Leu Val  Ala Tyr Thr 
    1100                 1105                 1110             


Val Ile  Phe Ile Phe Glu Lys  Gly Lys Gln Lys Lys  Val Thr Lys 
    1115                 1120                 1125             


Gly Ile  Glu Gly Ile Thr Val  Met Glu Gln Leu Arg  Phe Glu Gln 
    1130                 1135                 1140             


Asp Pro  Arg Glu Phe Leu Lys  Thr Lys Gly Tyr Glu  Gly Val Lys 
    1145                 1150                 1155             


Gln Trp  Leu Ile Leu Pro Lys  Tyr Ile Leu Phe Glu  Ala Gln Gly 
    1160                 1165                 1170             


Gly Tyr  Arg Arg Met Ile Ala  Ser His Gln Glu Thr  Gln Lys Ala 
    1175                 1180                 1185             


Asn Ser  Leu Ile Leu Pro Glu  Asn Leu Val Thr Leu  Leu Tyr His 
    1190                 1195                 1200             


Ala Arg  His Tyr Asp Glu Ile  Asn His Lys Val Ser  Phe Asp Tyr 
    1205                 1210                 1215             


Val Asn  Ala His Lys Glu Gly  Phe Asn Asp Ile Phe  Asp Phe Ile 
    1220                 1225                 1230             


Ser Asp  Phe Gly Val Arg Tyr  Ile Leu Ala Pro Gln  His Leu Glu 
    1235                 1240                 1245             


Lys Ile  Lys Val Ala Tyr Glu  Lys Asn Lys Glu Val  Asp Leu Lys 
    1250                 1255                 1260             


Glu Met  Ile Asp Ala Ile Leu  Ser Leu Leu Lys Phe  Thr Leu Phe 
    1265                 1270                 1275             


Gly Ala  Ser Val Glu Phe Lys  Phe Phe Asp Ile Lys  Ile Leu Lys 
    1280                 1285                 1290             


Arg Tyr  Lys Ser Leu Thr Asp  Ile Trp Glu Ala Thr  Ile Ile Tyr 
    1295                 1300                 1305             


Gln Ser  Val Thr Gly Leu Tyr  Glu Arg Arg Val Glu  Val Arg Lys 
    1310                 1315                 1320             


Leu Trp  Asp Gly Glu Arg Leu  
    1325                 1330 


<210>  269
<211>  1334
<212>  PRT
<213>  Enterococcus phoeniculicola

<400>  269

Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Glu Asn Tyr Asp Leu Val Lys Lys Lys Met 
            20                  25                  30          


Lys Val Tyr Gly Asn Thr Glu Thr Lys Tyr Leu Lys Lys Asn Leu Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Glu Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Thr Arg Arg Arg Tyr Ser Arg Arg Arg Asn Arg Ile Cys 
65                  70                  75                  80  


Arg Leu Gln Asp Leu Phe Thr Glu Glu Met Asn Gln Val Asp Ala Asn 
                85                  90                  95      


Phe Phe His Arg Leu Gln Glu Ser Phe Leu Val Pro Asp Glu Lys Glu 
            100                 105                 110         


Phe Glu Arg His Ala Ile Phe Gly Lys Met Glu Glu Glu Val Ser Tyr 
        115                 120                 125             


Tyr Arg Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Thr Ser Glu Gln Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Ser Glu Thr Phe Arg Thr Phe Ile Gln Val Tyr 
            180                 185                 190         


Asn Gln Ile Phe Arg Glu Asn Glu Val Pro Leu Ala Val Pro Asp Asn 
        195                 200                 205             


Ile Glu Glu Leu Phe Ser Glu Lys Val Ser Arg Ala Arg Lys Val Glu 
    210                 215                 220                 


Ala Ile Leu Ser Val Tyr Ser Glu Glu Lys Ser Thr Gly Thr Leu Ala 
225                 230                 235                 240 


Gln Phe Leu Lys Leu Met Val Gly Asn Gln Gly Arg Phe Lys Lys Thr 
                245                 250                 255     


Phe Asp Leu Glu Glu Asp Gly Ile Ile Gln Ile Pro Lys Glu Glu Tyr 
            260                 265                 270         


Glu Glu Glu Leu Glu Thr Leu Leu Ala Ile Ile Gly Asp Glu Tyr Ala 
        275                 280                 285             


Glu Ile Phe Ser Ala Thr Lys Ser Val Tyr Asp Ala Val Ala Leu Ser 
    290                 295                 300                 


Gly Ile Leu Ser Val Thr Asp Gly Asp Thr Lys Ala Lys Leu Ser Ala 
305                 310                 315                 320 


Ser Met Val Glu Arg Tyr Glu Ala His Gln Lys Asp Leu Val Gln Phe 
                325                 330                 335     


Lys Gln Phe Ile Arg Lys Glu Leu Pro Glu Met Tyr Ala Pro Ile Phe 
            340                 345                 350         


Arg Asp Asn Ser Val Ser Gly Tyr Ala Gly Tyr Val Glu Asn Ser Lys 
        355                 360                 365             


Val Val Thr Gln Ala Glu Phe Tyr Lys Tyr Ile Lys Lys Ala Ile Glu 
    370                 375                 380                 


Lys Val Pro Gly Ala Glu Tyr Phe Leu Glu Lys Ile Glu Gln Glu Thr 
385                 390                 395                 400 


Phe Leu Asp Lys Gln Arg Thr Phe Asn Asn Gly Val Ile Pro His Gln 
                405                 410                 415     


Ile His Leu Glu Glu Leu Glu Ala Ile Ile Gln Lys Gln Ala Thr Tyr 
            420                 425                 430         


Tyr Pro Phe Leu Ala Asp Asn Lys Glu Glu Met Lys Gln Leu Val Thr 
        435                 440                 445             


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Asp Gly Asn Ser Pro 
    450                 455                 460                 


Phe Ala Trp Leu Glu Arg Ile Ser Ser Glu Pro Ile Arg Pro Gly Asn 
465                 470                 475                 480 


Leu Ala Glu Val Val Asp Ile Lys Lys Ser Ala Thr Lys Phe Ile Glu 
                485                 490                 495     


Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro Thr Glu Lys Val Leu Pro 
            500                 505                 510         


Lys His Ser Met Ile Tyr Glu Lys Tyr Met Val Tyr Asn Glu Leu Thr 
        515                 520                 525             


Lys Val Ser Tyr Val Asp Glu Arg Gly Met Asn Gln Arg Phe Ser Gly 
    530                 535                 540                 


Glu Glu Lys Lys Gln Ile Val Glu Glu Leu Phe Lys Gln Ser Arg Lys 
545                 550                 555                 560 


Val Thr Lys Lys Leu Leu Glu Lys Phe Leu Ser Asn Glu Phe Gly Leu 
                565                 570                 575     


Val Asp Val Ala Ile Lys Gly Ile Glu Thr Ser Phe Asn Ala Gly Tyr 
            580                 585                 590         


Gly Thr Tyr His Asp Phe Leu Lys Ile Gly Ile Thr Arg Glu Gln Leu 
        595                 600                 605             


Asp Lys Glu Glu Asn Ser Glu Thr Leu Glu Glu Ile Val Lys Ile Leu 
    610                 615                 620                 


Thr Val Phe Glu Asp Arg Lys Met Ile Arg Glu Gln Leu Lys Lys Tyr 
625                 630                 635                 640 


Thr Tyr Leu Phe Asp Glu Glu Val Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Ile Gly Ile Lys 
            660                 665                 670         


Glu Lys Arg Thr His Lys Thr Ile Leu Asp Tyr Leu Ile Glu Asp Asp 
        675                 680                 685             


Gly Gly Lys Gln Pro Ile Asn Arg Asn Leu Met Gln Leu Ile Asn Asp 
    690                 695                 700                 


Ser Asp Leu Ser Phe Lys Ser Glu Ile Ala Glu Ala Gln Ser Asp Met 
705                 710                 715                 720 


Asn Thr Glu Asp Leu His Glu Val Val Gln Asn Leu Ala Gly Ser Pro 
                725                 730                 735     


Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu 
            740                 745                 750         


Val Asp Ile Met Gly Ser Leu Pro Lys Asn Ile Val Val Glu Met Ala 
        755                 760                 765             


Arg Glu Asn Gln Thr Thr Ser Arg Gly Arg Thr Asn Ser Asn Pro Arg 
    770                 775                 780                 


Met Lys Ala Leu Glu Glu Ala Met Arg Asn Leu Arg Ser Asn Leu Leu 
785                 790                 795                 800 


Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Asp Arg Leu Tyr 
                805                 810                 815     


Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Leu Asp Leu 
            820                 825                 830         


Ser Leu His Asn Leu Ser Ser Tyr Asp Ile Asp His Ile Val Pro Gln 
        835                 840                 845             


Ser Phe Thr Thr Asp Asn Ser Leu Asp Asn Arg Val Leu Val Ser Ser 
    850                 855                 860                 


Lys Glu Asn Arg Gly Lys Lys Asp Asp Val Pro Ser Lys Glu Val Val 
865                 870                 875                 880 


Gln Lys Asn Ile Thr Leu Trp Glu Thr Leu Lys Asn Ser Asn Leu Ile 
                885                 890                 895     


Ser Gln Lys Lys Tyr Asp Asn Leu Thr Lys Gly Leu Arg Gly Gly Leu 
            900                 905                 910         


Thr Glu Asp Asp Arg Ala His Phe Ile Lys Arg Gln Leu Val Glu Thr 
        915                 920                 925             


Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Gln Arg Phe Asn 
    930                 935                 940                 


Ser Gln Lys Asp Glu Glu Gly Lys Thr Ile Arg Ala Val Arg Val Val 
945                 950                 955                 960 


Thr Leu Lys Ser Ser Leu Thr Ser Gln Phe Arg Lys Gln Phe Ala Ile 
                965                 970                 975     


His Lys Val Arg Glu Ile Asn Asp Tyr His His Gly His Asp Ala Tyr 
            980                 985                 990         


Leu Asn Gly Val Val Ala Asn Ser  Leu Leu Arg Val Tyr  Pro Gln Leu 
        995                 1000                 1005             


Gln Pro  Glu Phe Val Tyr Gly  Asp Tyr Pro Lys Phe  Asn Ala Tyr 
    1010                 1015                 1020             


Lys Ala  Asn Lys Ala Thr Ala  Lys Lys Gln Leu Tyr  Thr Asn Ile 
    1025                 1030                 1035             


Met Lys  Phe Phe Ala Glu Asp  Ala Val Ile Ile Asp  Glu Asn Gly 
    1040                 1045                 1050             


Glu Ile  Leu Trp Asp Lys Lys  Asn Ile Ala Thr Val  Lys Lys Val 
    1055                 1060                 1065             


Met Ser  Tyr Pro Gln Met Asn  Ile Val Lys Lys Pro  Glu Ile Gln 
    1070                 1075                 1080             


Thr Gly  Ser Phe Ser Lys Glu  Thr Ile Lys Pro Lys  Gly Asp Ser 
    1085                 1090                 1095             


Asp Lys  Leu Ile Ser Arg Lys  Thr Asn Trp Ser Pro  Lys Leu Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Gln  Val Ala Tyr Ser Val  Ile Ile Thr 
    1115                 1120                 1125             


Tyr Glu  Lys Gly Lys Lys Lys  Val Arg Ala Lys Ala  Ile Val Gly 
    1130                 1135                 1140             


Ile Thr  Ile Met Glu Gln Ser  Leu Phe Lys Lys Asp  Pro Val Ser 
    1145                 1150                 1155             


Leu Leu  Glu Glu Lys Gly Tyr  Ala Asn Pro Glu Val  Leu Ile His 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Leu Glu Asn Gly  Arg Arg Arg 
    1175                 1180                 1185             


Leu Leu  Ala Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Leu Val 
    1190                 1195                 1200             


Leu Pro  Ala Ser Leu Val Thr  Leu Leu Tyr His Ala  Lys Gln Val 
    1205                 1210                 1215             


Asp Glu  Asp Ser Gly Lys Ser  Glu Glu Tyr Val Arg  Glu His Arg 
    1220                 1225                 1230             


Ala Glu  Phe Ala Glu Ile Leu  Asn Tyr Val Gln Ala  Phe Ser Glu 
    1235                 1240                 1245             


Thr Lys  Ile Leu Ala Asn Lys  Asn Leu Gln Thr Ile  Leu Lys Leu 
    1250                 1255                 1260             


Tyr Glu  Glu Asn Lys Glu Ala  Asp Ile Lys Glu Ile  Ala Glu Ser 
    1265                 1270                 1275             


Phe Val  Asn Leu Met Lys Phe  Ser Ala Tyr Gly Ala  Pro Met Asp 
    1280                 1285                 1290             


Phe Lys  Phe Phe Gly Lys Thr  Ile Pro Arg Ser Arg  Tyr Thr Ser 
    1295                 1300                 1305             


Val Gly  Glu Leu Leu Ser Ala  Thr Ile Ile Asn Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Thr Arg Arg  Lys Leu Val Asp 
    1325                 1330                 


<210>  270
<211>  1330
<212>  PRT
<213>  Unknown

<220>
<223>  Enterococcus sp. AM1

<400>  270

Met Gly Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Gln Glu Asp Leu Asp Leu Val Arg Arg Lys Met 
            20                  25                  30          


Lys Val Tyr Gly Asn Thr Glu Lys Asn Tyr Leu Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Asp Leu Phe Asp Glu Gly Met Thr Ala Lys Asp Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Thr Arg Arg Arg Tyr Phe Arg Arg Arg Gln Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Thr Phe Phe Gln Glu Glu Met Asn Arg Ile Asp Pro Asn 
                85                  90                  95      


Phe Phe Asn Arg Leu Asp Glu Ser Phe Leu Ile Glu Glu Asp Lys Leu 
            100                 105                 110         


Ser Glu Arg His Pro Ile Phe Gly Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Lys Asn Tyr Ala Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Ala Glu Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Arg Leu Ser Thr 
                165                 170                 175     


Glu Asn Thr Ser Thr Glu Glu Thr Phe Lys Thr Phe Leu Gln Lys Tyr 
            180                 185                 190         


Asn Gln Thr Phe Asn Pro Val Asp Glu Thr Ile Ser Ile Gly Ser Ile 
        195                 200                 205             


Phe Ala Asp Lys Val Ser Arg Ala Lys Lys Ala Glu Gly Val Leu Ala 
    210                 215                 220                 


Leu Phe Pro Asp Glu Lys Arg Asn Gly Thr Phe Asp Gln Phe Leu Lys 
225                 230                 235                 240 


Met Ile Val Gly Asn Gln Gly Asn Phe Lys Lys Thr Phe Glu Leu Glu 
                245                 250                 255     


Glu Asp Ala Lys Leu Gln Phe Ser Lys Glu Glu Tyr Asp Glu Ser Leu 
            260                 265                 270         


Glu Ala Leu Leu Gly Glu Ile Gly Asp Glu Tyr Ala Asp Val Phe Glu 
        275                 280                 285             


Ala Ala Lys Asn Val Tyr Asn Ala Val Glu Leu Ser Gly Ile Leu Thr 
    290                 295                 300                 


Val Thr Asp Asn Ser Thr Lys Ala Lys Leu Ser Ala Ser Met Ile Lys 
305                 310                 315                 320 


Arg Tyr Glu Asp His Lys Thr Asp Leu Lys Leu Phe Lys Glu Phe Ile 
                325                 330                 335     


Arg Lys Asn Leu Pro Glu Lys Tyr His Glu Ile Phe Asn Asp Lys Asn 
            340                 345                 350         


Thr Asp Gly Tyr Ala Gly Tyr Ile Asp Asn Ser Lys Lys Thr Ser Gln 
        355                 360                 365             


Glu Lys Phe Tyr Lys Tyr Ile Thr Asn Leu Ile Glu Lys Ile Asp Gly 
    370                 375                 380                 


Ala Glu Tyr Phe Leu Lys Lys Ile Glu Asn Glu Asp Phe Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ile Ile Pro His Gln Ile His Leu Glu 
                405                 410                 415     


Glu Leu Lys Ala Ile Leu His His Gln Ala Met Tyr Tyr Pro Phe Leu 
            420                 425                 430         


Gln Glu Lys Phe Ser Asn Phe Val Asp Leu Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Asn Gly Asn Ser Arg Phe Ser Trp Leu 
    450                 455                 460                 


Ser Arg Lys Ser Asp Glu Pro Ile Arg Pro Trp Asn Leu Ala Glu Val 
465                 470                 475                 480 


Val Asp Leu Ser Lys Ser Ala Glu Leu Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Leu Tyr Leu Pro Ser Glu Lys Val Leu Pro Lys His Ser Met 
            500                 505                 510         


Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr Lys Val Thr Tyr 
        515                 520                 525             


Lys Asp Glu Gln Gly Lys Val Gln Asn Phe Ser Ser Glu Glu Lys Glu 
    530                 535                 540                 


Arg Ile Phe Ile Asp Leu Phe Lys Gln His Arg Lys Val Thr Lys Lys 
545                 550                 555                 560 


Asp Leu Ser Asn Phe Leu Arg Asn Glu Tyr Asn Leu Asp Asp Val Ile 
                565                 570                 575     


Ile Asp Gly Ile Glu Asn Lys Phe Asn Ala Ser Phe Asn Thr Tyr His 
            580                 585                 590         


Asp Phe Leu Lys Leu Lys Ile Asp Pro Lys Val Leu Asp Asp Pro Ala 
        595                 600                 605             


Asn Glu Pro Met Phe Glu Glu Ile Val Lys Ile Leu Thr Ile Phe Glu 
    610                 615                 620                 


Asp Arg Lys Met Leu Arg Glu Gln Leu Ser Lys Phe Ser Asp Arg Leu 
625                 630                 635                 640 


Ser Glu Lys Thr Ile Lys Asp Leu Glu Arg Arg His Tyr Thr Gly Trp 
                645                 650                 655     


Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile His Asp Lys Gln Ser 
            660                 665                 670         


Asn Lys Thr Ile Leu Asp Tyr Leu Ile Asn Asp Asp Ala Pro Lys Lys 
        675                 680                 685             


Asn Ile Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asn Arg Leu Thr 
    690                 695                 700                 


Phe Lys Glu Glu Ile Glu Lys Glu Gln Leu Lys Ala Asn Ser Glu Glu 
705                 710                 715                 720 


Ser Leu Ile Glu Ile Val Gln Asn Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Phe Gln Ser Leu Lys Ile Val Asp Glu Leu Val Glu Ile 
            740                 745                 750         


Met Gly Tyr Ala Pro Thr Asn Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Asn Gly Arg Arg Asn Ser Arg Pro Arg Leu Lys Asn 
    770                 775                 780                 


Leu Glu Lys Ala Ile Asp Asp Leu Asp Ser Glu Ile Leu Lys Lys His 
785                 790                 795                 800 


Pro Val Asp Asn Lys Ala Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr 
                805                 810                 815     


Leu Gln Asn Gly Lys Asp Met Tyr Thr Asn Glu Glu Leu Asp Ile His 
            820                 825                 830         


Lys Leu Ser Thr Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe Ile 
        835                 840                 845             


Val Asp Asn Ser Leu Asp Asn Arg Val Leu Val Ser Ser Ser Lys Asn 
    850                 855                 860                 


Arg Gly Lys Leu Asp Asp Val Pro Ser Lys Glu Val Val Lys Lys Met 
865                 870                 875                 880 


Arg Ala Phe Trp Glu Ser Leu Tyr Arg Ser Gly Leu Ile Ser Lys Lys 
                885                 890                 895     


Lys Phe Asp Asn Leu Val Lys Ala Glu Ser Gly Gly Leu Ser Glu Asp 
            900                 905                 910         


Asp Lys Ala Gly Phe Ile His Arg Gln Leu Val Glu Thr Arg Gln Ile 
        915                 920                 925             


Thr Lys Asn Val Ala Arg Ile Leu His Gln Arg Phe Asn Ser Glu Lys 
    930                 935                 940                 


Asp Glu Glu Gly Asn Leu Ile Arg Lys Val Arg Ile Ile Thr Leu Lys 
945                 950                 955                 960 


Ser Ala Leu Thr Ser Gln Phe Arg Lys Asn Tyr Gly Ile Tyr Lys Ile 
                965                 970                 975     


Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Gly 
            980                 985                 990         


Val Val Ala Thr Ala Leu Leu Lys  Ile Tyr Pro Gln Leu  Glu Pro Glu 
        995                 1000                 1005             


Phe Val  Tyr Gly Glu Phe His  Arg Phe Asn Ala Phe  Lys Glu Asn 
    1010                 1015                 1020             


Lys Ala  Thr Ala Lys Lys Gln  Phe Tyr Ser Asn Leu  Met Glu Phe 
    1025                 1030                 1035             


Ser Lys  Ser Asp Lys Val Ile  Ile Asp Glu Asn Gly  Glu Ile Leu 
    1040                 1045                 1050             


Trp Asn  Gln Lys Lys Ile Val  Thr Val Lys Lys Val  Met Asn Tyr 
    1055                 1060                 1065             


Arg Gln  Met Asn Ile Val Lys  Lys Val Glu Ile Gln  Lys Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Ser  Arg Lys Lys Glu Trp  Asp Thr Thr Lys Tyr  Gly Gly Phe 
    1100                 1105                 1110             


Asp Ser  Pro Asn Val Ala Tyr  Ser Val Val Ile Arg  Tyr Glu Lys 
    1115                 1120                 1125             


Gly Lys  Thr Arg Lys Leu Val  Lys Thr Ile Val Gly  Ile Thr Ile 
    1130                 1135                 1140             


Met Glu  Arg Ala Ala Phe Glu  Lys Asn Glu Arg Glu  Phe Leu Lys 
    1145                 1150                 1155             


Asn Lys  Gly Tyr Gln Asn Pro  Gln Ile Cys Met Lys  Leu Pro Lys 
    1160                 1165                 1170             


Tyr Ser  Leu Tyr Glu Phe Asp  Asp Gly Arg Arg Arg  Leu Leu Ala 
    1175                 1180                 1185             


Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln Met Val  Leu Pro Ala 
    1190                 1195                 1200             


His Leu  Val Thr Phe Leu Tyr  His Ala Lys His Cys  Asn Glu Lys 
    1205                 1210                 1215             


Pro Asp  Ser Leu Lys Tyr Val  Thr Glu His Gln Ser  Gly Phe Ser 
    1220                 1225                 1230             


Glu Ile  Met Ala His Val Lys  Asp Phe Ala Glu Lys  Tyr Thr Leu 
    1235                 1240                 1245             


Val Asp  Lys Asn Leu Glu Lys  Ile Leu Ser Leu Tyr  Ala Lys Asn 
    1250                 1255                 1260             


Met Asp  Ser Glu Val Lys Glu  Ile Ala Gln Ser Phe  Val Asp Leu 
    1265                 1270                 1275             


Met Gln  Leu Asn Ala Phe Gly  Ala Pro Ala Asp Phe  Lys Phe Phe 
    1280                 1285                 1290             


Gly Glu  Thr Ile Pro Arg Lys  Arg Tyr Thr Ser Val  Asn Glu Leu 
    1295                 1300                 1305             


Leu Glu  Ala Thr Ile Ile Asn  Gln Ser Ile Thr Gly  Leu Tyr Glu 
    1310                 1315                 1320             


Thr Arg  Arg Arg Leu Gly Asp  
    1325                 1330 


<210>  271
<211>  1339
<212>  PRT
<213>  Enterococcus villorum

<400>  271

Met Asn Lys Ala Tyr Thr Leu Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Arg Leu Met Ala Lys Lys Met 
            20                  25                  30          


Pro Val His Ser Lys Met Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Ala Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Glu Arg Arg Asn 
    50                  55                  60                  


Lys Arg Ala Thr Arg Arg Arg Leu Arg Arg Arg Lys Tyr Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ser Glu Glu Ile Leu Lys Lys Asp Ser His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asp Glu Ser Phe Leu Ile Pro Glu Asp Lys Gln 
            100                 105                 110         


Tyr Ala Arg Phe Pro Ile Phe Pro Thr Leu Leu Glu Glu Lys Ala Tyr 
        115                 120                 125             


Tyr Gln Asn Tyr Pro Thr Ile Tyr His Leu Arg Gln Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Phe Glu Gly Glu Leu Asp Thr 
                165                 170                 175     


Glu Asn Thr Ser Val Glu Glu Thr Phe Lys Glu Phe Ile Asp Ile Tyr 
            180                 185                 190         


Asn Glu Gln Phe Glu Glu Gly Ile Ile Phe Tyr Lys Asp Ile Pro Leu 
        195                 200                 205             


Ile Leu Thr Asp Lys Leu Ser Lys Ser Lys Lys Val Glu Lys Ile Leu 
    210                 215                 220                 


Gln Tyr Tyr Pro Lys Glu Lys Thr Thr Gly Cys Leu Ala Gln Phe Leu 
225                 230                 235                 240 


Lys Leu Ile Val Gly Asn Gln Gly Asn Phe Lys Gln Ala Phe His Leu 
                245                 250                 255     


Asp Glu Glu Val Lys Ile Gln Ile Ser Lys Glu Thr Tyr Glu Glu Asp 
            260                 265                 270         


Leu Glu Lys Leu Leu Arg Lys Ser Asn Glu Glu Met Ile Asp Val Phe 
        275                 280                 285             


Leu Gln Val Lys Lys Val Tyr Asp Ala Ile Leu Leu Ser Asp Ile Leu 
    290                 295                 300                 


Ser Thr Lys Met Lys Asp Thr Lys Ala Lys Leu Ser Ala Gly Met Ile 
305                 310                 315                 320 


Glu Arg Tyr Gln Asn His Lys Lys Asp Leu Glu Glu Leu Lys Gln Phe 
                325                 330                 335     


Val Arg Ala His Leu His Glu Lys Val Thr Val Phe Phe Lys Asp Ser 
            340                 345                 350         


Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Thr Gln Ala 
        355                 360                 365             


Asp Phe Tyr Lys Phe Leu Lys Lys Glu Leu Thr Gly Val Pro Gly Ser 
    370                 375                 380                 


Glu Pro Met Leu Ala Lys Ile Asp Gln Glu Asn Phe Leu Leu Lys Gln 
385                 390                 395                 400 


Arg Thr Pro Thr Asn Gly Val Ile Pro His Gln Val His Leu Thr Glu 
                405                 410                 415     


Phe Lys Ala Ile Ile Asp Gln Gln Lys Gln Tyr Tyr Pro Phe Leu Glu 
            420                 425                 430         


Lys Ser Lys Glu Lys Met Ile Gln Leu Leu Thr Phe Arg Ile Pro Tyr 
        435                 440                 445             


Tyr Val Gly Pro Leu Ala Gln Asp Lys Glu Thr Ser Ser Phe Ala Trp 
    450                 455                 460                 


Leu Glu Arg Lys Thr Thr Glu Lys Ile Lys Pro Trp Asn Ala Lys Asp 
465                 470                 475                 480 


Val Ile Asp Tyr Gly Ala Ser Ala Thr Lys Phe Ile Gln Arg Met Ile 
                485                 490                 495     


Asn Tyr Asp Thr Tyr Leu Pro Thr Glu Lys Val Leu Pro Lys Tyr Ser 
            500                 505                 510         


Met Leu Tyr Gln Lys Tyr Thr Ile Phe Asn Glu Leu Thr Lys Val Ala 
        515                 520                 525             


Tyr Lys Asp Asp Arg Gly Ile Lys His Gln Phe Ser Ser Glu Glu Lys 
    530                 535                 540                 


Leu Arg Ile Phe Gln Glu Leu Phe Lys Lys Gln Arg Arg Val Thr Lys 
545                 550                 555                 560 


Lys Lys Leu Gln His Phe Leu Ser Ala Asn Tyr Asn Ile Glu Asp Ala 
                565                 570                 575     


Glu Ile Leu Gly Val Asp Lys Val Phe Asn Ser Ser Tyr Ala Thr Tyr 
            580                 585                 590         


His Asp Phe Leu Glu Leu Ala Lys Pro Tyr Thr Glu Lys Ile Ile Glu 
        595                 600                 605             


Leu Leu Glu Gln Pro Glu Met Glu Glu Met Phe Glu Asp Ile Val Lys 
    610                 615                 620                 


Ile Ile Thr Ile Phe Glu Asp Arg Glu Met Val Arg Thr Gln Leu Lys 
625                 630                 635                 640 


Lys Tyr Gln Arg Ile Leu Gly Glu Glu Ile Phe Lys Lys Leu Val Lys 
                645                 650                 655     


Lys Lys Tyr Thr Gly Trp Gly Arg Leu Ser Lys Arg Leu Ile Asn Gly 
            660                 665                 670         


Ile Arg Asp Gln Lys Thr Asn Lys Thr Ile Leu Asp Tyr Leu Ile Asn 
        675                 680                 685             


Asp Asp Asp Phe Pro Tyr Asn Arg Asn Arg Asn Phe Met Gln Leu Ile 
    690                 695                 700                 


Asn Asp Asp His Leu Ser Phe Lys Glu Glu Ile Ala Lys Glu Leu Thr 
705                 710                 715                 720 


Leu Ser Asp Lys Gln Ser Leu Leu Glu Val Val Glu Ala Ile Pro Gly 
                725                 730                 735     


Ser Pro Ala Ile Lys Lys Gly Ile Trp Gln Thr Leu Lys Ile Val Glu 
            740                 745                 750         


Glu Leu Ile Ala Ile Ile Gly Tyr Lys Pro Lys Asn Ile Val Ile Glu 
        755                 760                 765             


Met Ala Arg Glu Asn Gln Thr Thr Thr Gly Gly Lys Asn Arg Ser Lys 
    770                 775                 780                 


Pro Arg Leu Lys Ser Leu Glu Glu Ala Leu Lys Asn Phe Asp Ser Gln 
785                 790                 795                 800 


Leu Leu Lys Glu Arg Pro Val Asp Asn Gln Ser Leu Gln Lys Asp Arg 
                805                 810                 815     


Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu 
            820                 825                 830         


Ser Leu Asp Ile Asp Arg Leu Ser Glu Tyr Asp Ile Asp His Ile Ile 
        835                 840                 845             


Pro Arg Ser Phe Ile Val Asp His Ser Leu Asp Asn Lys Val Leu Val 
    850                 855                 860                 


Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp Asp Val Pro Asp Ser Lys 
865                 870                 875                 880 


Val Val Lys Arg Met Lys Ala Tyr Trp Glu Lys Leu Leu Arg Ala Asn 
                885                 890                 895     


Leu Ile Ser Glu Arg Lys Phe Ser Tyr Leu Thr Lys Leu Glu Leu Thr 
            900                 905                 910         


Asp Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Ala Ile Leu His Gln Tyr Phe Asn Gln 
    930                 935                 940                 


Thr Gln Glu Leu Glu Lys Glu Lys Asp Ile Arg Ile Ile Thr Leu Lys 
945                 950                 955                 960 


Ser Ser Leu Val Ser Gln Phe Arg Gln Val Phe Gly Ile His Lys Val 
                965                 970                 975     


Arg Glu Ile Asn His His His His Ala His Asp Ala Tyr Leu Asn Ala 
            980                 985                 990         


Val Val Ala Leu Ala Leu Leu Lys  Lys Tyr Pro Arg Leu  Ala Pro Glu 
        995                 1000                 1005             


Phe Val  Tyr Gly Ser Phe Ala  Lys Phe His Leu Val  Lys Glu Asn 
    1010                 1015                 1020             


Lys Ala  Thr Ala Lys Lys Glu  Phe Tyr Ser Asn Ile  Leu Lys Phe 
    1025                 1030                 1035             


Phe Glu  Lys Glu Glu Gln Phe  Cys Asp Glu Asn Gly  Glu Ile Phe 
    1040                 1045                 1050             


Trp Asp  Lys Arg Lys His Ile  Gln Gln Ile Lys Lys  Val Ile Ser 
    1055                 1060                 1065             


Ser His  Gln Val Asn Ile Val  Lys Lys Val Glu Val  Gln Thr Gly 
    1070                 1075                 1080             


Ser Phe  Tyr Lys Glu Thr Val  Asn Thr Lys Glu Lys  Pro Asp Lys 
    1085                 1090                 1095             


Leu Ile  Lys Arg Lys Asn Asn  Trp Asp Val Thr Lys  Tyr Gly Gly 
    1100                 1105                 1110             


Phe Gly  Ser Pro Val Val Ala  Tyr Ala Val Val Phe  Thr Tyr Glu 
    1115                 1120                 1125             


Lys Gly  Lys Asn His Lys Lys  Ala Lys Ala Ile Glu  Gly Ile Thr 
    1130                 1135                 1140             


Ile Met  Glu Gln Ala Leu Phe  Glu Lys Asp Pro Ile  Ser Phe Leu 
    1145                 1150                 1155             


Ile Glu  Lys Gly Tyr Ser Asn  Val Asn Gln Phe Ile  Lys Leu Pro 
    1160                 1165                 1170             


Lys Tyr  Thr Leu Phe Glu Leu  Ala Asn Gly Gln Arg  Arg Met Leu 
    1175                 1180                 1185             


Ala Ser  His Gln Glu Leu Gln  Lys Ala Asn Ser Phe  Ile Leu Pro 
    1190                 1195                 1200             


Glu Lys  Leu Val Thr Leu Leu  Tyr His Ala Asn His  Tyr Asp Glu 
    1205                 1210                 1215             


Ile Ala  Tyr Lys Asp Ser Tyr  Asp Tyr Val Asn Glu  His Phe Ser 
    1220                 1225                 1230             


Asn Phe  Gln Asp Ile Leu Asp  Lys Val Ile Ile Phe  Ala Glu Lys 
    1235                 1240                 1245             


Tyr Thr  Ser Ala Pro Gln Lys  Leu Asn Gln Ile Ile  Ala Thr Tyr 
    1250                 1255                 1260             


Glu Lys  Asn Gln Glu Ala Asp  Arg Lys Ile Met Ala  His Ser Phe 
    1265                 1270                 1275             


Val Asn  Leu Met Gln Phe Asn  Ala Leu Gly Ala Pro  Ala Asp Phe 
    1280                 1285                 1290             


Lys Phe  Phe Asp Thr Thr Ile  Thr Arg Lys Arg Tyr  Thr Ser Leu 
    1295                 1300                 1305             


Thr Glu  Ile Trp Gln Ser Thr  Ile Ile Tyr Gln Ser  Val Thr Gly 
    1310                 1315                 1320             


Leu Tyr  Glu Thr Arg Arg Arg  Met Ala Asp Leu Trp  Asp Gly Val 
    1325                 1330                 1335             


Gln 
    


<210>  272
<211>  1424
<212>  PRT
<213>  Unknown

<220>
<223>  Expression vector pCas9

<400>  272

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala Asp Lys Lys Tyr Ser Ile Gly Leu 
        35                  40                  45              


Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
    50                  55                  60                  


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
65                  70                  75                  80  


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
                85                  90                  95      


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
            100                 105                 110         


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
        115                 120                 125             


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
    130                 135                 140                 


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
145                 150                 155                 160 


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
                165                 170                 175     


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
            180                 185                 190         


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
        195                 200                 205             


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
    210                 215                 220                 


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
225                 230                 235                 240 


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
                245                 250                 255     


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
            260                 265                 270         


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
        275                 280                 285             


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
    290                 295                 300                 


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
305                 310                 315                 320 


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
                325                 330                 335     


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
            340                 345                 350         


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
        355                 360                 365             


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
    370                 375                 380                 


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
385                 390                 395                 400 


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
                405                 410                 415     


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
            420                 425                 430         


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
        435                 440                 445             


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
    450                 455                 460                 


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
465                 470                 475                 480 


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
                485                 490                 495     


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
            500                 505                 510         


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
        515                 520                 525             


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
    530                 535                 540                 


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
545                 550                 555                 560 


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
                565                 570                 575     


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
            580                 585                 590         


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
        595                 600                 605             


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
    610                 615                 620                 


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
625                 630                 635                 640 


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
                645                 650                 655     


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
            660                 665                 670         


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
        675                 680                 685             


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
    690                 695                 700                 


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
705                 710                 715                 720 


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
                725                 730                 735     


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
            740                 745                 750         


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
        755                 760                 765             


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
    770                 775                 780                 


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
785                 790                 795                 800 


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
                805                 810                 815     


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
            820                 825                 830         


Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu 
        835                 840                 845             


Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp 
    850                 855                 860                 


Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile 
865                 870                 875                 880 


Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu 
                885                 890                 895     


Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu 
            900                 905                 910         


Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala 
        915                 920                 925             


Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
    930                 935                 940                 


Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu 
945                 950                 955                 960 


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser 
                965                 970                 975     


Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val 
            980                 985                 990         


Lys Val Ile Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
        995                 1000                 1005             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1010                 1015                 1020             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1025                 1030                 1035             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1040                 1045                 1050             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1055                 1060                 1065             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1070                 1075                 1080             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1085                 1090                 1095             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1100                 1105                 1110             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1115                 1120                 1125             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1130                 1135                 1140             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1145                 1150                 1155             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1160                 1165                 1170             


Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1175                 1180                 1185             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1190                 1195                 1200             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1205                 1210                 1215             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1220                 1225                 1230             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1235                 1240                 1245             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1250                 1255                 1260             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1265                 1270                 1275             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1280                 1285                 1290             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1295                 1300                 1305             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1310                 1315                 1320             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1325                 1330                 1335             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1340                 1345                 1350             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1355                 1360                 1365             


Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1370                 1375                 1380             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1385                 1390                 1395             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Lys Arg Pro  Ala Ala Thr 
    1400                 1405                 1410             


Lys Lys  Ala Gly Gln Ala Lys  Lys Lys Lys Lys 
    1415                 1420                 


<210>  273
<211>  1343
<212>  PRT
<213>  Kandleria vitulina

<400>  273

Met Ser Gln Asn Asn Asn Lys Ile Tyr Asn Ile Gly Leu Asp Ile Gly 
1               5                   10                  15      


Asp Ala Ser Val Gly Trp Ala Val Val Asp Glu His Tyr Asn Leu Leu 
            20                  25                  30          


Lys Arg His Gly Lys His Met Trp Gly Ser Arg Leu Phe Thr Gln Ala 
        35                  40                  45              


Asn Thr Ala Val Glu Arg Arg Ser Ser Arg Ser Thr Arg Arg Arg Tyr 
    50                  55                  60                  


Asn Lys Arg Arg Glu Arg Ile Arg Leu Leu Arg Gly Ile Met Glu Asp 
65                  70                  75                  80  


Met Val Leu Asp Val Asp Pro Thr Phe Phe Ile Arg Leu Ala Asn Val 
                85                  90                  95      


Ser Phe Leu Asp Gln Glu Asp Lys Lys Asp Tyr Leu Lys Glu Asn Tyr 
            100                 105                 110         


His Ser Asn Tyr Asn Leu Phe Ile Asp Lys Asp Phe Asn Asp Lys Thr 
        115                 120                 125             


Tyr Tyr Asp Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys His Leu Cys 
    130                 135                 140                 


Glu Ser Lys Glu Lys Glu Asp Pro Arg Leu Ile Tyr Leu Ala Leu His 
145                 150                 155                 160 


His Ile Val Lys Tyr Arg Gly Asn Phe Leu Tyr Glu Gly Gln Lys Phe 
                165                 170                 175     


Ser Met Asp Val Ser Asn Ile Glu Asp Lys Met Ile Asp Val Leu Arg 
            180                 185                 190         


Gln Phe Asn Glu Ile Asn Leu Phe Glu Tyr Val Glu Asp Arg Lys Lys 
        195                 200                 205             


Ile Asp Glu Val Leu Asn Val Leu Lys Glu Pro Leu Ser Lys Lys His 
    210                 215                 220                 


Lys Ala Asp Lys Ala Phe Ala Leu Phe Asp Thr Thr Lys Asp Asn Lys 
225                 230                 235                 240 


Ala Ala Tyr Lys Glu Leu Cys Ala Ala Leu Ala Gly Asn Lys Phe Asn 
                245                 250                 255     


Val Thr Lys Met Leu Lys Glu Ala Glu Leu His Asp Glu Asp Glu Lys 
            260                 265                 270         


Asp Ile Ser Phe Lys Phe Ser Asp Ala Thr Phe Asp Asp Ala Phe Val 
        275                 280                 285             


Glu Lys Gln Pro Leu Leu Gly Asp Cys Val Glu Phe Ile Asp Leu Leu 
    290                 295                 300                 


His Asp Ile Tyr Ser Trp Val Glu Leu Gln Asn Ile Leu Gly Ser Ala 
305                 310                 315                 320 


His Thr Ser Glu Pro Ser Ile Ser Ala Ala Met Ile Gln Arg Tyr Glu 
                325                 330                 335     


Asp His Lys Asn Asp Leu Lys Leu Leu Lys Asp Val Ile Arg Lys Tyr 
            340                 345                 350         


Leu Pro Lys Lys Tyr Phe Glu Val Phe Arg Asp Glu Lys Ser Lys Lys 
        355                 360                 365             


Asn Asn Tyr Cys Asn Tyr Ile Asn His Pro Ser Lys Thr Pro Val Asp 
    370                 375                 380                 


Glu Phe Tyr Lys Tyr Ile Lys Lys Leu Ile Glu Lys Ile Asp Asp Pro 
385                 390                 395                 400 


Asp Val Lys Thr Ile Leu Asn Lys Ile Glu Leu Glu Ser Phe Met Leu 
                405                 410                 415     


Lys Gln Asn Ser Arg Thr Asn Gly Ala Val Pro Tyr Gln Met Gln Leu 
            420                 425                 430         


Asp Glu Leu Asn Lys Ile Leu Glu Asn Gln Ser Val Tyr Tyr Ser Asp 
        435                 440                 445             


Leu Lys Asp Asn Glu Asp Lys Ile Arg Ser Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Phe Gly Pro Leu Asn Ile Thr Lys Asp Arg Gln Phe Asp 
465                 470                 475                 480 


Trp Ile Ile Lys Lys Glu Gly Lys Glu Asn Glu Arg Ile Leu Pro Trp 
                485                 490                 495     


Asn Ala Asn Glu Ile Val Asp Val Asp Lys Thr Ala Asp Glu Phe Ile 
            500                 505                 510         


Lys Arg Met Arg Asn Phe Cys Thr Tyr Phe Pro Asp Glu Pro Val Leu 
        515                 520                 525             


Ala Lys Asn Ser Leu Thr Val Ser Lys Tyr Glu Val Leu Asn Glu Ile 
    530                 535                 540                 


Asn Lys Leu Arg Ile Asn Asp His Leu Ile Lys Arg Asp Ile Lys Asp 
545                 550                 555                 560 


Lys Met Leu His Thr Leu Phe Met Asp His Lys Ser Ile Ser Ala Asn 
                565                 570                 575     


Ala Met Lys Lys Trp Leu Val Lys Asn Gln Tyr Phe Ser Asn Thr Asp 
            580                 585                 590         


Asp Ile Lys Ile Glu Gly Phe Gln Lys Glu Asn Ala Cys Ser Thr Ser 
        595                 600                 605             


Leu Thr Pro Trp Ile Asp Phe Thr Lys Ile Phe Gly Glu Ile Asn Asn 
    610                 615                 620                 


Ser Asn Tyr Glu Leu Ile Glu Lys Ile Ile Tyr Asp Val Thr Val Phe 
625                 630                 635                 640 


Glu Asp Lys Lys Ile Leu Arg Arg Arg Leu Lys Lys Glu Tyr Asp Leu 
                645                 650                 655     


Asp Glu Glu Lys Ile Lys Lys Ile Leu Lys Leu Lys Tyr Ser Gly Trp 
            660                 665                 670         


Ser Arg Leu Ser Lys Lys Leu Leu Ser Gly Ile Lys Thr Lys Tyr Lys 
        675                 680                 685             


Asp Ser Thr Arg Thr Pro Glu Thr Val Leu Glu Val Met Glu Arg Thr 
    690                 695                 700                 


Asn Met Asn Leu Met Gln Val Ile Asn Asp Glu Lys Leu Gly Phe Lys 
705                 710                 715                 720 


Lys Thr Ile Asp Asp Ala Asn Ser Thr Ser Val Ser Gly Lys Phe Ser 
                725                 730                 735     


Tyr Ala Glu Val Gln Glu Leu Ala Gly Ser Pro Ala Ile Lys Arg Gly 
            740                 745                 750         


Ile Trp Gln Ala Leu Leu Ile Val Asp Glu Ile Lys Lys Ile Met Lys 
        755                 760                 765             


His Glu Pro Ala His Val Tyr Ile Glu Phe Ala Arg Asn Glu Asp Glu 
    770                 775                 780                 


Lys Glu Arg Lys Asp Ser Phe Val Asn Gln Met Leu Lys Leu Tyr Lys 
785                 790                 795                 800 


Asp Tyr Asp Phe Glu Asp Glu Thr Glu Lys Glu Ala Asn Lys His Leu 
                805                 810                 815     


Lys Gly Glu Asp Ala Lys Ser Lys Ile Arg Ser Glu Arg Leu Lys Leu 
            820                 825                 830         


Tyr Tyr Thr Gln Met Gly Lys Cys Met Tyr Thr Gly Lys Ser Leu Asp 
        835                 840                 845             


Ile Asp Arg Leu Asp Thr Tyr Gln Val Asp His Ile Val Pro Gln Ser 
    850                 855                 860                 


Leu Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Val Leu Ser Ser 
865                 870                 875                 880 


Glu Asn Gln Arg Lys Leu Asp Asp Leu Val Ile Pro Glu Met Ile Arg 
                885                 890                 895     


Asn Lys Met Phe Gly Phe Trp Asn Lys Leu Tyr Glu Asn Lys Ile Ile 
            900                 905                 910         


Ser Pro Lys Lys Phe Tyr Ser Leu Ile Lys Ser Glu Tyr Ser Asp Lys 
        915                 920                 925             


Asp Lys Glu Arg Phe Ile Asn Arg Gln Ile Val Glu Thr Arg Gln Ile 
    930                 935                 940                 


Thr Lys His Val Ala Gln Ile Ile Ser Asn His Tyr Glu Thr Thr Lys 
945                 950                 955                 960 


Val Val Thr Val Arg Ala Asp Leu Ser His Ala Phe Arg Glu Arg Tyr 
                965                 970                 975     


His Ile Tyr Lys Asn Arg Asp Ile Asn Asp Phe His His Ala His Asp 
            980                 985                 990         


Ala Tyr Ile Ala Thr Ile Leu Gly  Thr Tyr Ile Gly His  Arg Phe Glu 
        995                 1000                 1005             


Ser Leu  Asp Ala Lys Tyr Ile  Tyr Gly Glu Tyr Gln  Lys Ile Phe 
    1010                 1015                 1020             


Arg Asn  Asn Lys Asn Lys Asp  Lys Glu Phe Asn Lys  Asn Lys Asp 
    1025                 1030                 1035             


Gly Phe  Ile Leu Asn Ser Met  Arg Asn Leu Tyr Ala  Asp Lys Asp 
    1040                 1045                 1050             


Thr Gly  Glu Val Val Trp Asp  Pro Glu Trp Ile Ser  Arg Ile Lys 
    1055                 1060                 1065             


Lys Cys  Phe Tyr Tyr Lys Asp  Cys Phe Val Thr Lys  Lys Leu Glu 
    1070                 1075                 1080             


Glu Asn  Asn Gly Ser Phe Phe  Asn Leu Thr Val Arg  Pro Asn Asp 
    1085                 1090                 1095             


Glu His  Ser Glu Lys Gly Thr  Thr Ile Ala Lys Val  Pro Val Asn 
    1100                 1105                 1110             


Lys Leu  Arg Ser Asn Val His  Lys Tyr Gly Gly Phe  Glu Gly Leu 
    1115                 1120                 1125             


Lys Tyr  Ser Ile Val Ala Ile  Lys Gly Lys Lys Lys  Lys Gly Lys 
    1130                 1135                 1140             


Lys Ile  Ile Asp Val Asn Lys  Leu Val Gly Ile Pro  Leu Met Tyr 
    1145                 1150                 1155             


Lys Asn  Val Asp Asp Glu Thr  Lys Ile Asn Tyr Ile  Lys Glu Ser 
    1160                 1165                 1170             


Glu Gly  Leu Glu Glu Val Lys  Ile Ile Lys Glu Ile  Leu Lys Asn 
    1175                 1180                 1185             


Gln Leu  Ile Glu Ile Asn Gly  Gly Leu Phe Tyr Val  Thr Ser Pro 
    1190                 1195                 1200             


Thr Glu  Ile Val Asn Ala Arg  Gln Leu Ile Leu Asp  Phe Asn Cys 
    1205                 1210                 1215             


Thr Arg  Ile Ile Asp Gly Ile  Tyr Lys Ala Met Lys  Tyr Lys Asn 
    1220                 1225                 1230             


Tyr Ser  Glu Leu Ser Gln Glu  Glu Ile Met Asn Val  Tyr Asp Ile 
    1235                 1240                 1245             


Phe Val  Glu Lys Leu Lys Leu  Tyr Tyr Pro Thr Tyr  Lys Asn Ile 
    1250                 1255                 1260             


Ala Thr  Asn Phe Glu Asn Met  Arg Glu Gln Phe Glu  Asn Ile Ser 
    1265                 1270                 1275             


Asp Glu  Glu Lys Cys Glu Val  Ile Arg Gln Met Leu  Val Val Met 
    1280                 1285                 1290             


His Ala  Gly Pro Gln Asn Gly  Asn Ile Thr Phe Asp  Asp Phe Lys 
    1295                 1300                 1305             


Leu Ser  Asn Arg Leu Gly Arg  Leu Asn Cys Lys Thr  Ile Ser Leu 
    1310                 1315                 1320             


Asp Thr  Thr Val Phe Ile Ala  Asp Ser Pro Thr Gly  Met Tyr Ser 
    1325                 1330                 1335             


Lys Lys  Tyr Lys Leu 
    1340             


<210>  274
<211>  1344
<212>  PRT
<213>  Kandleria vitulina

<400>  274

Met Ser Gln Asn Asn Asn Lys Ile Tyr Asn Ile Gly Leu Asp Ile Gly 
1               5                   10                  15      


Asp Ala Ser Val Gly Trp Ala Val Val Asp Glu His Tyr Asn Leu Leu 
            20                  25                  30          


Lys Arg His Gly Lys His Met Trp Gly Ser Arg Leu Phe Thr Gln Ala 
        35                  40                  45              


Asn Thr Ala Val Glu Arg Arg Ser Ser Arg Ser Thr Arg Arg Arg Tyr 
    50                  55                  60                  


Asn Lys Arg Arg Glu Arg Ile Arg Leu Leu Arg Glu Ile Met Glu Asp 
65                  70                  75                  80  


Met Val Leu Asp Val Asp Pro Thr Phe Phe Ile Arg Leu Ala Asn Val 
                85                  90                  95      


Ser Phe Leu Asp Gln Glu Asp Lys Lys Asp Tyr Leu Lys Glu Asn Tyr 
            100                 105                 110         


His Ser Asn Tyr Asn Leu Phe Ile Asp Lys Asp Phe Asn Asp Lys Thr 
        115                 120                 125             


Tyr Tyr Asp Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys His Leu Cys 
    130                 135                 140                 


Glu Ser Lys Glu Lys Glu Asp Pro Arg Leu Ile Tyr Leu Ala Leu His 
145                 150                 155                 160 


His Ile Val Lys Tyr Arg Gly Asn Phe Leu Tyr Glu Gly Gln Lys Phe 
                165                 170                 175     


Ser Met Asp Val Ser Asn Ile Glu Asp Lys Met Ile Asp Val Leu Arg 
            180                 185                 190         


Gln Phe Asn Glu Ile Asn Leu Phe Glu Tyr Val Glu Asp Arg Lys Lys 
        195                 200                 205             


Ile Asp Glu Val Leu Asn Val Leu Lys Glu Pro Leu Ser Lys Lys His 
    210                 215                 220                 


Lys Ala Glu Lys Ala Phe Ala Leu Phe Asp Thr Thr Lys Asp Asn Lys 
225                 230                 235                 240 


Ala Ala Tyr Lys Glu Leu Cys Ala Ala Leu Ala Gly Asn Lys Phe Asn 
                245                 250                 255     


Val Thr Lys Met Leu Lys Glu Ala Glu Leu His Asp Glu Asp Glu Lys 
            260                 265                 270         


Asp Ile Ser Phe Lys Phe Ser Asp Ala Thr Phe Asp Asp Ala Phe Val 
        275                 280                 285             


Glu Lys Gln Pro Leu Leu Gly Asp Cys Val Glu Phe Ile Asp Leu Leu 
    290                 295                 300                 


His Asp Ile Tyr Ser Trp Val Glu Leu Gln Asn Ile Leu Gly Ser Ala 
305                 310                 315                 320 


His Thr Ser Glu Pro Ser Ile Ser Ala Ala Met Ile Gln Arg Tyr Glu 
                325                 330                 335     


Asp His Lys Asn Asp Leu Lys Leu Leu Lys Asp Val Ile Arg Lys Tyr 
            340                 345                 350         


Leu Pro Lys Lys Tyr Phe Glu Val Phe Arg Asp Glu Lys Ser Lys Lys 
        355                 360                 365             


Asn Asn Tyr Cys Asn Tyr Ile Asn His Pro Ser Lys Thr Pro Val Asp 
    370                 375                 380                 


Glu Phe Tyr Lys Tyr Ile Lys Lys Leu Ile Glu Lys Ile Asp Asp Pro 
385                 390                 395                 400 


Asp Val Lys Thr Ile Leu Asn Lys Ile Glu Leu Glu Ser Phe Met Leu 
                405                 410                 415     


Lys Gln Asn Ser Arg Thr Asn Gly Ala Val Pro Tyr Gln Met Gln Leu 
            420                 425                 430         


Asp Glu Leu Asn Lys Ile Leu Glu Asn Gln Ser Val Tyr Tyr Ser Asp 
        435                 440                 445             


Leu Lys Asp Asn Glu Asp Lys Ile Arg Ser Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Phe Gly Pro Leu Asn Ile Thr Lys Asp Arg Gln Phe Asp 
465                 470                 475                 480 


Trp Ile Ile Lys Lys Glu Gly Lys Glu Asn Glu Arg Ile Leu Pro Trp 
                485                 490                 495     


Asn Ala Asn Glu Ile Val Asp Val Asp Lys Thr Ala Asp Glu Phe Ile 
            500                 505                 510         


Lys Arg Met Arg Asn Phe Cys Thr Tyr Phe Pro Asp Glu Pro Val Met 
        515                 520                 525             


Ala Lys Asn Ser Leu Thr Val Ser Lys Tyr Glu Val Leu Asn Glu Ile 
    530                 535                 540                 


Asn Lys Leu Arg Ile Asn Asp His Leu Ile Lys Arg Asp Met Lys Asp 
545                 550                 555                 560 


Lys Met Leu His Thr Leu Phe Met Asp His Lys Ser Ile Ser Ala Asn 
                565                 570                 575     


Ala Met Lys Lys Trp Leu Val Lys Asn Gln Tyr Phe Ser Asn Thr Asp 
            580                 585                 590         


Asp Ile Lys Ile Glu Gly Phe Gln Lys Glu Asn Ala Cys Ser Thr Ser 
        595                 600                 605             


Leu Thr Pro Trp Ile Asp Phe Thr Lys Ile Phe Gly Lys Ile Asn Glu 
    610                 615                 620                 


Ser Asn Tyr Asp Phe Ile Glu Lys Ile Ile Tyr Asp Val Thr Val Phe 
625                 630                 635                 640 


Glu Asp Lys Lys Ile Leu Arg Arg Arg Leu Lys Lys Glu Tyr Asp Leu 
                645                 650                 655     


Asp Glu Glu Lys Ile Lys Lys Ile Leu Lys Leu Lys Tyr Ser Gly Trp 
            660                 665                 670         


Ser Arg Leu Ser Lys Lys Leu Leu Ser Gly Ile Lys Thr Lys Tyr Lys 
        675                 680                 685             


Asp Ser Thr Arg Thr Pro Glu Thr Val Leu Glu Val Met Glu Arg Thr 
    690                 695                 700                 


Asn Met Asn Leu Met Gln Val Ile Asn Asp Glu Lys Leu Gly Phe Lys 
705                 710                 715                 720 


Lys Thr Ile Asp Asp Ala Asn Ser Thr Ser Val Ser Gly Lys Phe Ser 
                725                 730                 735     


Tyr Ala Glu Val Gln Glu Leu Ala Gly Ser Pro Ala Ile Lys Arg Gly 
            740                 745                 750         


Ile Trp Gln Ala Leu Leu Ile Val Asp Glu Ile Lys Lys Ile Met Lys 
        755                 760                 765             


His Glu Pro Ala His Val Tyr Ile Glu Phe Ala Arg Asn Glu Asp Glu 
    770                 775                 780                 


Lys Glu Arg Lys Asp Ser Phe Val Asn Gln Met Leu Lys Leu Tyr Lys 
785                 790                 795                 800 


Asp Tyr Asp Phe Glu Asp Glu Thr Glu Lys Glu Ala Asn Lys His Leu 
                805                 810                 815     


Lys Gly Glu Asp Ala Lys Ser Lys Ile Arg Ser Glu Arg Leu Lys Leu 
            820                 825                 830         


Tyr Tyr Thr Gln Met Gly Lys Cys Met Tyr Thr Gly Lys Ser Leu Asp 
        835                 840                 845             


Ile Asp Arg Leu Asp Thr Tyr Gln Val Asp His Ile Val Pro Gln Ser 
    850                 855                 860                 


Leu Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Val Leu Ser Ser 
865                 870                 875                 880 


Glu Asn Gln Arg Lys Leu Asp Asp Leu Val Ile Pro Ser Ser Ile Arg 
                885                 890                 895     


Asn Lys Met Tyr Gly Phe Trp Glu Lys Leu Phe Asn Asn Lys Ile Ile 
            900                 905                 910         


Ser Pro Lys Lys Phe Tyr Ser Leu Ile Lys Thr Glu Phe Asn Glu Lys 
        915                 920                 925             


Asp Gln Glu Arg Phe Ile Asn Arg Gln Ile Val Glu Thr Arg Gln Ile 
    930                 935                 940                 


Thr Lys His Val Ala Gln Ile Ile Asp Asn His Tyr Glu Asn Thr Lys 
945                 950                 955                 960 


Val Val Thr Val Arg Ala Asp Leu Ser His Gln Phe Arg Glu Arg Tyr 
                965                 970                 975     


His Ile Tyr Lys Asn Arg Asp Ile Asn Asp Phe His His Ala His Asp 
            980                 985                 990         


Ala Tyr Ile Ala Thr Ile Leu Gly  Thr Tyr Ile Gly His  Arg Phe Glu 
        995                 1000                 1005             


Ser Leu  Asp Ala Lys Tyr Ile  Tyr Gly Glu Tyr Lys  Arg Ile Phe 
    1010                 1015                 1020             


Arg Asn  Gln Lys Asn Lys Gly  Lys Glu Met Lys Lys  Asn Asn Asp 
    1025                 1030                 1035             


Gly Phe  Ile Leu Asn Ser Met  Arg Asn Ile Tyr Ala  Asp Lys Asp 
    1040                 1045                 1050             


Thr Gly  Glu Ile Val Trp Asp  Pro Asn Tyr Ile Asp  Arg Ile Lys 
    1055                 1060                 1065             


Lys Cys  Phe Tyr Tyr Lys Asp  Cys Phe Val Thr Lys  Lys Leu Glu 
    1070                 1075                 1080             


Glu Asn  Asn Gly Thr Phe Phe  Asn Val Thr Val Leu  Pro Asn Asp 
    1085                 1090                 1095             


Thr Asn  Ser Asp Lys Asp Asn  Thr Leu Ala Thr Val  Pro Val Asn 
    1100                 1105                 1110             


Lys Tyr  Arg Ser Asn Val Asn  Lys Tyr Gly Gly Phe  Ser Gly Val 
    1115                 1120                 1125             


Asn Ser  Phe Ile Val Ala Ile  Lys Gly Lys Lys Lys  Lys Gly Lys 
    1130                 1135                 1140             


Lys Val  Ile Glu Val Asn Lys  Leu Thr Gly Ile Pro  Leu Met Tyr 
    1145                 1150                 1155             


Lys Asn  Ala Asp Glu Glu Ile  Lys Ile Asn Tyr Leu  Lys Gln Ala 
    1160                 1165                 1170             


Glu Asp  Leu Glu Glu Val Gln  Ile Gly Lys Glu Ile  Leu Lys Asn 
    1175                 1180                 1185             


Gln Leu  Ile Glu Lys Asp Gly  Gly Leu Tyr Tyr Ile  Val Ala Pro 
    1190                 1195                 1200             


Thr Glu  Ile Ile Asn Ala Lys  Gln Leu Ile Leu Asn  Glu Ser Gln 
    1205                 1210                 1215             


Thr Lys  Leu Val Cys Glu Ile  Tyr Lys Ala Met Lys  Tyr Lys Asn 
    1220                 1225                 1230             


Tyr Asp  Asn Leu Asp Ser Glu  Lys Ile Ile Asp Leu  Tyr Arg Leu 
    1235                 1240                 1245             


Leu Ile  Asn Lys Met Glu Leu  Tyr Tyr Pro Glu Tyr  Arg Lys Gln 
    1250                 1255                 1260             


Leu Val  Lys Lys Phe Glu Asp  Arg Tyr Glu Gln Leu  Lys Val Ile 
    1265                 1270                 1275             


Ser Ile  Glu Glu Lys Cys Asn  Ile Ile Lys Gln Ile  Leu Ala Thr 
    1280                 1285                 1290             


Leu His  Cys Asn Ser Ser Ile  Gly Lys Ile Met Tyr  Ser Asp Phe 
    1295                 1300                 1305             


Lys Ile  Ser Thr Thr Ile Gly  Arg Leu Asn Gly Arg  Thr Ile Ser 
    1310                 1315                 1320             


Leu Asp  Asp Ile Ser Phe Ile  Ala Glu Ser Pro Thr  Gly Met Tyr 
    1325                 1330                 1335             


Ser Lys  Lys Tyr Lys Leu 
    1340                 


<210>  275
<211>  1314
<212>  PRT
<213>  Lactobacillus animalis

<400>  275

Met Leu Lys Lys Asp Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly His Ala Val Val Thr Asp Asp Tyr Lys Val Pro Thr Lys Lys 
            20                  25                  30          


Met Lys Val Phe Gly Asp Thr Ser Lys Lys Thr Ile Lys Lys Asn Met 
        35                  40                  45              


Leu Gly Val Leu Leu Phe Asn Glu Gly Gln Thr Ala Ala Asp Thr Arg 
    50                  55                  60                  


Leu Lys Arg Gly Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Pro Ala Leu Ala Lys Val Asp Pro 
                85                  90                  95      


Asn Phe Phe Tyr Arg Leu Glu Glu Ser Ser Leu Val Ala Glu Asp Lys 
            100                 105                 110         


Lys Tyr Asp Val Tyr Pro Ile Phe Gly Lys Arg Glu Glu Glu Leu Leu 
        115                 120                 125             


Tyr His Asp Thr His Lys Thr Ile Tyr His Leu Arg Ser Glu Leu Ala 
    130                 135                 140                 


Asn Asn Asp Arg Pro Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Ile Ile Lys Tyr Arg Gly Asn Phe Leu Leu Glu Gly Glu Ile Asp 
                165                 170                 175     


Leu Arg Thr Thr Asp Ile Asn Lys Val Phe Ala Glu Phe Ser Glu Thr 
            180                 185                 190         


Leu Asn Glu Asn Ser Asp Glu Asn Leu Gly Lys Leu Asp Val Ala Asp 
        195                 200                 205             


Ile Phe Lys Asp Asn Thr Phe Ser Lys Thr Lys Lys Ser Glu Glu Leu 
    210                 215                 220                 


Leu Lys Leu Ser Gly Ala Lys Lys Asn Gln Leu Ala His Gln Leu Phe 
225                 230                 235                 240 


Lys Met Met Val Gly Asn Met Gly Ser Phe Lys Lys Val Leu Gly Thr 
                245                 250                 255     


Asp Glu Glu His Lys Leu Ser Phe Gly Lys Asp Thr Tyr Glu Asp Asp 
            260                 265                 270         


Leu Asn Asp Leu Leu Ala Glu Ala Gly Asp Gln Tyr Leu Asp Ile Phe 
        275                 280                 285             


Val Ala Ala Lys Lys Val Tyr Asp Ala Ala Ile Leu Ala Ser Ile Leu 
    290                 295                 300                 


Asp Val Lys Asp Thr Gln Thr Lys Thr Val Phe Ser Gln Ala Met Ile 
305                 310                 315                 320 


Glu Arg Tyr Glu Glu His Gln Lys Asp Leu Ile Glu Leu Lys Arg Val 
                325                 330                 335     


Phe Lys Lys Tyr Leu Pro Glu Lys Cys His Asp Phe Phe Ser Glu Pro 
            340                 345                 350         


Lys Ile Ser Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Val Ser Glu Glu 
        355                 360                 365             


Asp Phe Tyr Lys Tyr Thr Lys Lys Thr Leu Lys Gly Ile Pro Glu Thr 
    370                 375                 380                 


Glu Glu Ile Leu Gln Lys Ile Asp Ala Asn Asn Tyr Leu Arg Lys Gln 
385                 390                 395                 400 


Arg Thr Phe Asp Asn Gly Ala Ile Pro His Gln Val His Leu Lys Glu 
                405                 410                 415     


Leu Val Ala Ile Val Glu Asn Gln Gly Lys Tyr Tyr Pro Phe Leu Arg 
            420                 425                 430         


Glu Asn Lys Asp Lys Phe Glu Lys Ile Leu Asn Phe Arg Ile Pro Tyr 
        435                 440                 445             


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Lys Phe Ala Trp Leu Thr 
    450                 455                 460                 


Arg Ala Gly Glu Gly Lys Ile Thr Pro Tyr Asn Phe Asp Glu Met Ile 
465                 470                 475                 480 


Asp Lys Glu Thr Ser Ala Glu Asp Phe Ile Lys Arg Met Thr Ile Asn 
                485                 490                 495     


Asp Leu Tyr Leu Pro Thr Glu Pro Val Leu Pro Lys His Ser Leu Leu 
            500                 505                 510         


Tyr Glu Arg Tyr Thr Ile Phe Asn Glu Leu Ala Gly Val Arg Tyr Val 
        515                 520                 525             


Thr Glu Asn Gly Glu Ala Lys Tyr Phe Asp Ala Gln Thr Lys Arg Ser 
    530                 535                 540                 


Ile Phe Glu Leu Phe Lys Leu Asp Arg Lys Val Ser Glu Lys Met Val 
545                 550                 555                 560 


Ile Lys His Leu Lys Val Val Met Pro Ala Ile Arg Ile Gln Ala Leu 
                565                 570                 575     


Lys Gly Leu Asp Asn Gly Lys Phe Asn Ala Ser Tyr Gly Thr Tyr Lys 
            580                 585                 590         


Asp Leu Val Asp Met Gly Val Ala Pro Glu Leu Leu Asn Asp Glu Val 
        595                 600                 605             


Asn Ser Glu Lys Trp Glu Asp Ile Ile Lys Thr Leu Thr Ile Phe Glu 
    610                 615                 620                 


Gly Arg Lys Leu Ile Lys Arg Arg Leu Glu Asn Tyr Arg Asp Phe Leu 
625                 630                 635                 640 


Gly Glu Asp Ile Leu Arg Lys Leu Ser Arg Lys Lys Tyr Thr Gly Trp 
                645                 650                 655     


Gly Arg Leu Ser Ala Lys Leu Leu Asp Gly Ile Tyr Asp Lys Lys Thr 
            660                 665                 670         


His Lys Thr Ile Leu Asp Cys Leu Met Thr Glu Asp Tyr Ser Gln Asn 
        675                 680                 685             


Phe Met Gln Leu Ile Asn Asp Asp Thr Tyr Ser Phe Lys Glu Thr Ile 
    690                 695                 700                 


Lys Asn Ala Gln Val Ile Glu Lys Glu Glu Thr Leu Ala Lys Thr Val 
705                 710                 715                 720 


Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser 
                725                 730                 735     


Leu Glu Ile Val Asp Glu Ile Ile Lys Val Met Gly Tyr Lys Pro Lys 
            740                 745                 750         


Ser Ile Val Val Glu Met Ala Arg Glu Thr Gln Lys Thr His Gly Thr 
        755                 760                 765             


Arg Lys Arg Glu Asp Arg Val Gln Gln Ile Val Lys Asn Leu Lys Asp 
    770                 775                 780                 


Ala Asn Glu Leu Pro Lys Lys Leu Pro Ser Asn Ala Glu Leu Ser Asp 
785                 790                 795                 800 


Glu Arg Lys Tyr Leu Tyr Cys Leu Gln Asn Gly Arg Asp Met Tyr Thr 
                805                 810                 815     


Gly Ala Pro Leu Asp Tyr Asp His Leu Gln Phe Tyr Asp Val Asp His 
            820                 825                 830         


Ile Ile Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Glu Asn Lys Val 
        835                 840                 845             


Leu Thr Ile Lys Lys Glu Asn Val Arg Lys Thr Asn Gly Leu Pro Ser 
    850                 855                 860                 


Glu Ala Val Ile Gln Lys Met Gly Ser Phe Trp Lys Lys Leu Leu Asp 
865                 870                 875                 880 


Ala Gly Ala Met Thr Asn Lys Lys Tyr Asp Asn Leu Arg Arg Asn Leu 
                885                 890                 895     


His Gly Gly Leu Asn Glu Lys Leu Lys Glu Arg Phe Ile Glu Arg Gln 
            900                 905                 910         


Leu Val Glu Thr Arg Gln Ile Thr Lys Tyr Val Ala Gln Leu Leu Asp 
        915                 920                 925             


Gln Arg Leu Asn Tyr Asp Gly Asn Gly Val Glu Leu Asp Glu Lys Ile 
    930                 935                 940                 


Ala Ile Val Thr Leu Lys Ala Gln Leu Ala Ser Gln Phe Arg Ser Glu 
945                 950                 955                 960 


Phe Lys Leu Arg Lys Val Arg Ala Leu Asn Asn Leu His His Ala His 
                965                 970                 975     


Asp Ala Tyr Leu Asn Ala Val Val Ala Asn Leu Ile Met Ala Lys Tyr 
            980                 985                 990         


Pro Glu Leu Glu Pro Glu Phe Val  Tyr Gly Lys Tyr Arg  Lys Thr Lys 
        995                 1000                 1005             


Phe Lys  Gly Leu Gly Lys Ala  Thr Ala Lys Asn Thr  Leu Tyr Ala 
    1010                 1015                 1020             


Asn Val  Leu Tyr Phe Leu Lys  Glu Asn Glu Val Tyr  Pro Phe Trp 
    1025                 1030                 1035             


Asp Lys  Ala Arg Asp Leu Pro  Thr Ile Lys Arg Tyr  Leu Tyr Arg 
    1040                 1045                 1050             


Ala Gln  Val Asn Lys Val Arg  Lys Ala Glu Arg Gln  Thr Gly Gly 
    1055                 1060                 1065             


Phe Ser  Asp Glu Met Leu Val  Pro Lys Ser Asp Ser  Gly Lys Leu 
    1070                 1075                 1080             


Leu Pro  Arg Lys Glu Gly Leu  Asp Pro Val Lys Tyr  Gly Gly Tyr 
    1085                 1090                 1095             


Ala Lys  Ala Val Glu Ser Tyr  Ala Val Leu Ile Thr  Ala Asp Glu 
    1100                 1105                 1110             


Val Lys  Lys Gly Lys Thr Lys  Lys Val Lys Thr Leu  Val Asn Ile 
    1115                 1120                 1125             


Pro Ile  Ile Asp Ser Lys Lys  Tyr Glu Ala Asp Pro  Thr Ala Tyr 
    1130                 1135                 1140             


Leu Ala  Ser Arg Gly Tyr Thr  Asn Val Thr Asn Ser  Phe Ile Leu 
    1145                 1150                 1155             


Pro Lys  Tyr Ser Leu Leu Glu  Asp Pro Glu Gly Arg  Arg Arg Tyr 
    1160                 1165                 1170             


Leu Ala  Ser Phe Lys Glu Phe  Gln Lys Ala Asn Glu  Leu Ile Leu 
    1175                 1180                 1185             


Pro Gln  His Leu Val Glu Leu  Leu Tyr Trp Val Asn  Ala Lys Asp 
    1190                 1195                 1200             


Gly Glu  Gln Lys Leu Glu Asp  His Lys Ala Glu Phe  Lys Glu Leu 
    1205                 1210                 1215             


Phe Asp  Lys Ile Met Glu Phe  Ala Asp Lys Tyr Val  Val Ala Pro 
    1220                 1225                 1230             


Lys Asn  Ser Glu Lys Ile Arg  Arg Leu Tyr Glu Glu  Asn Gln Asp 
    1235                 1240                 1245             


Ala Thr  Pro Met Glu Leu Gly  Lys Asn Phe Val Glu  Leu Leu Arg 
    1250                 1255                 1260             


Tyr Thr  Ala Asp Gly Ala Ala  Ser Asp Phe Lys Phe  Phe Gly Glu 
    1265                 1270                 1275             


Asn Ile  Pro Arg Lys Arg Tyr  Asn Ser Ala Gly Ser  Leu Leu Asn 
    1280                 1285                 1290             


Gly Thr  Leu Ile Tyr Gln Ser  Lys Thr Gly Leu Tyr  Glu Thr Arg 
    1295                 1300                 1305             


Ile Asp  Leu Gly Lys Leu 
    1310                 


<210>  276
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  276

Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr 
        35                  40                  45              


Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Thr Leu Gly Leu 
        195             


<210>  277
<211>  198
<212>  PRT
<213>  Mus musculus

<400>  277

Met Asp Ser Leu Leu Met Lys Gln Lys Lys Phe Leu Tyr His Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Cys Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ser Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Glu 
                85                  90                  95      


Phe Leu Arg Trp Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Gly Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn Arg Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Thr Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Met Leu Gly Phe 
        195             


<210>  278
<211>  198
<212>  PRT
<213>  S. canis

<400>  278

Met Asp Ser Leu Leu Met Lys Gln Arg Lys Phe Leu Tyr His Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ser Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Tyr Pro Asn Leu Ser Leu Arg Ile Phe Ala Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn Arg Glu Lys Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Thr Leu Gly Leu 
        195             


<210>  279
<211>  199
<212>  PRT
<213>  Bos Bovis

<400>  279

Met Asp Ser Leu Leu Lys Lys Gln Arg Gln Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Pro Thr Ser Phe Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ala Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Tyr Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Asp Lys Glu Arg Lys Ala Glu Pro Glu Gly Leu Arg 
        115                 120                 125             


Arg Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp 
    130                 135                 140                 


Tyr Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe 
145                 150                 155                 160 


Lys Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln 
                165                 170                 175     


Leu Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp 
            180                 185                 190         


Ala Phe Arg Thr Leu Gly Leu 
        195                 


<210>  280
<211>  429
<212>  PRT
<213>  Mus musculus

<400>  280

Met Gly Pro Phe Cys Leu Gly Cys Ser His Arg Lys Cys Tyr Ser Pro 
1               5                   10                  15      


Ile Arg Asn Leu Ile Ser Gln Glu Thr Phe Lys Phe His Phe Lys Asn 
            20                  25                  30          


Leu Gly Tyr Ala Lys Gly Arg Lys Asp Thr Phe Leu Cys Tyr Glu Val 
        35                  40                  45              


Thr Arg Lys Asp Cys Asp Ser Pro Val Ser Leu His His Gly Val Phe 
    50                  55                  60                  


Lys Asn Lys Asp Asn Ile His Ala Glu Ile Cys Phe Leu Tyr Trp Phe 
65                  70                  75                  80  


His Asp Lys Val Leu Lys Val Leu Ser Pro Arg Glu Glu Phe Lys Ile 
                85                  90                  95      


Thr Trp Tyr Met Ser Trp Ser Pro Cys Phe Glu Cys Ala Glu Gln Ile 
            100                 105                 110         


Val Arg Phe Leu Ala Thr His His Asn Leu Ser Leu Asp Ile Phe Ser 
        115                 120                 125             


Ser Arg Leu Tyr Asn Val Gln Asp Pro Glu Thr Gln Gln Asn Leu Cys 
    130                 135                 140                 


Arg Leu Val Gln Glu Gly Ala Gln Val Ala Ala Met Asp Leu Tyr Glu 
145                 150                 155                 160 


Phe Lys Lys Cys Trp Lys Lys Phe Val Asp Asn Gly Gly Arg Arg Phe 
                165                 170                 175     


Arg Pro Trp Lys Arg Leu Leu Thr Asn Phe Arg Tyr Gln Asp Ser Lys 
            180                 185                 190         


Leu Gln Glu Ile Leu Arg Pro Cys Tyr Ile Pro Val Pro Ser Ser Ser 
        195                 200                 205             


Ser Ser Thr Leu Ser Asn Ile Cys Leu Thr Lys Gly Leu Pro Glu Thr 
    210                 215                 220                 


Arg Phe Cys Val Glu Gly Arg Arg Met Asp Pro Leu Ser Glu Glu Glu 
225                 230                 235                 240 


Phe Tyr Ser Gln Phe Tyr Asn Gln Arg Val Lys His Leu Cys Tyr Tyr 
                245                 250                 255     


His Arg Met Lys Pro Tyr Leu Cys Tyr Gln Leu Glu Gln Phe Asn Gly 
            260                 265                 270         


Gln Ala Pro Leu Lys Gly Cys Leu Leu Ser Glu Lys Gly Lys Gln His 
        275                 280                 285             


Ala Glu Ile Leu Phe Leu Asp Lys Ile Arg Ser Met Glu Leu Ser Gln 
    290                 295                 300                 


Val Thr Ile Thr Cys Tyr Leu Thr Trp Ser Pro Cys Pro Asn Cys Ala 
305                 310                 315                 320 


Trp Gln Leu Ala Ala Phe Lys Arg Asp Arg Pro Asp Leu Ile Leu His 
                325                 330                 335     


Ile Tyr Thr Ser Arg Leu Tyr Phe His Trp Lys Arg Pro Phe Gln Lys 
            340                 345                 350         


Gly Leu Cys Ser Leu Trp Gln Ser Gly Ile Leu Val Asp Val Met Asp 
        355                 360                 365             


Leu Pro Gln Phe Thr Asp Cys Trp Thr Asn Phe Val Asn Pro Lys Arg 
    370                 375                 380                 


Pro Phe Trp Pro Trp Lys Gly Leu Glu Ile Ile Ser Arg Arg Thr Gln 
385                 390                 395                 400 


Arg Arg Leu Arg Arg Ile Lys Glu Ser Trp Gly Leu Gln Asp Leu Val 
                405                 410                 415     


Asn Asp Phe Gly Asn Leu Gln Leu Gly Pro Pro Met Ser 
            420                 425                 


<210>  281
<211>  429
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus

<400>  281

Met Gly Pro Phe Cys Leu Gly Cys Ser His Arg Lys Cys Tyr Ser Pro 
1               5                   10                  15      


Ile Arg Asn Leu Ile Ser Gln Glu Thr Phe Lys Phe His Phe Lys Asn 
            20                  25                  30          


Leu Arg Tyr Ala Ile Asp Arg Lys Asp Thr Phe Leu Cys Tyr Glu Val 
        35                  40                  45              


Thr Arg Lys Asp Cys Asp Ser Pro Val Ser Leu His His Gly Val Phe 
    50                  55                  60                  


Lys Asn Lys Asp Asn Ile His Ala Glu Ile Cys Phe Leu Tyr Trp Phe 
65                  70                  75                  80  


His Asp Lys Val Leu Lys Val Leu Ser Pro Arg Glu Glu Phe Lys Ile 
                85                  90                  95      


Thr Trp Tyr Met Ser Trp Ser Pro Cys Phe Glu Cys Ala Glu Gln Val 
            100                 105                 110         


Leu Arg Phe Leu Ala Thr His His Asn Leu Ser Leu Asp Ile Phe Ser 
        115                 120                 125             


Ser Arg Leu Tyr Asn Ile Arg Asp Pro Glu Asn Gln Gln Asn Leu Cys 
    130                 135                 140                 


Arg Leu Val Gln Glu Gly Ala Gln Val Ala Ala Met Asp Leu Tyr Glu 
145                 150                 155                 160 


Phe Lys Lys Cys Trp Lys Lys Phe Val Asp Asn Gly Gly Arg Arg Phe 
                165                 170                 175     


Arg Pro Trp Lys Lys Leu Leu Thr Asn Phe Arg Tyr Gln Asp Ser Lys 
            180                 185                 190         


Leu Gln Glu Ile Leu Arg Pro Cys Tyr Ile Pro Val Pro Ser Ser Ser 
        195                 200                 205             


Ser Ser Thr Leu Ser Asn Ile Cys Leu Thr Lys Gly Leu Pro Glu Thr 
    210                 215                 220                 


Arg Phe Cys Val Glu Arg Arg Arg Val His Leu Leu Ser Glu Glu Glu 
225                 230                 235                 240 


Phe Tyr Ser Gln Phe Tyr Asn Gln Arg Val Lys His Leu Cys Tyr Tyr 
                245                 250                 255     


His Gly Val Lys Pro Tyr Leu Cys Tyr Gln Leu Glu Gln Phe Asn Gly 
            260                 265                 270         


Gln Ala Pro Leu Lys Gly Cys Leu Leu Ser Glu Lys Gly Lys Gln His 
        275                 280                 285             


Ala Glu Ile Leu Phe Leu Asp Lys Ile Arg Ser Met Glu Leu Ser Gln 
    290                 295                 300                 


Val Ile Ile Thr Cys Tyr Leu Thr Trp Ser Pro Cys Pro Asn Cys Ala 
305                 310                 315                 320 


Trp Gln Leu Ala Ala Phe Lys Arg Asp Arg Pro Asp Leu Ile Leu His 
                325                 330                 335     


Ile Tyr Thr Ser Arg Leu Tyr Phe His Trp Lys Arg Pro Phe Gln Lys 
            340                 345                 350         


Gly Leu Cys Ser Leu Trp Gln Ser Gly Ile Leu Val Asp Val Met Asp 
        355                 360                 365             


Leu Pro Gln Phe Thr Asp Cys Trp Thr Asn Phe Val Asn Pro Lys Arg 
    370                 375                 380                 


Pro Phe Trp Pro Trp Lys Gly Leu Glu Ile Ile Ser Arg Arg Thr Gln 
385                 390                 395                 400 


Arg Arg Leu His Arg Ile Lys Glu Ser Trp Gly Leu Gln Asp Leu Val 
                405                 410                 415     


Asn Asp Phe Gly Asn Leu Gln Leu Gly Pro Pro Met Ser 
            420                 425                 


<210>  282
<211>  1387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  282

Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys Ser Glu Gln 
1               5                   10                  15      


Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met 
            20                  25                  30          


Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys 
        35                  40                  45              


Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp 
    50                  55                  60                  


Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln 
65                  70                  75                  80  


Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys 
                85                  90                  95      


Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys 
            100                 105                 110         


Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val 
        115                 120                 125             


Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys 
    130                 135                 140                 


Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg 
145                 150                 155                 160 


Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr 
                165                 170                 175     


Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 
            180                 185                 190         


Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu 
        195                 200                 205             


Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe 
    210                 215                 220                 


Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp 
225                 230                 235                 240 


Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp 
                245                 250                 255     


Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala 
            260                 265                 270         


Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His Arg Asp 
        275                 280                 285             


Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu 
    290                 295                 300                 


Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile 
305                 310                 315                 320 


Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu 
                325                 330                 335     


Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser 
            340                 345                 350         


Gln Leu Gly Gly Asp Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        355                 360                 365             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Asp Lys Lys Tyr Ser Ile Gly 
    370                 375                 380                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
385                 390                 395                 400 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                405                 410                 415     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            420                 425                 430         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        435                 440                 445             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    450                 455                 460                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
465                 470                 475                 480 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                485                 490                 495     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            500                 505                 510         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        515                 520                 525             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    530                 535                 540                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
545                 550                 555                 560 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                565                 570                 575     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            580                 585                 590         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        595                 600                 605             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    610                 615                 620                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
625                 630                 635                 640 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                645                 650                 655     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            660                 665                 670         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        675                 680                 685             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    690                 695                 700                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
705                 710                 715                 720 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                725                 730                 735     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            740                 745                 750         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        755                 760                 765             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    770                 775                 780                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
785                 790                 795                 800 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                805                 810                 815     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            820                 825                 830         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        835                 840                 845             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    850                 855                 860                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
865                 870                 875                 880 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                885                 890                 895     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            900                 905                 910         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        915                 920                 925             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    930                 935                 940                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
945                 950                 955                 960 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                965                 970                 975     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            980                 985                 990         


Glu Asp Ile Val Leu Thr Leu Thr  Leu Phe Glu Asp Arg  Glu Met Ile 
        995                 1000                 1005             


Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val 
    1010                 1015                 1020             


Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr Gly Trp  Gly Arg Leu 
    1025                 1030                 1035             


Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys 
    1040                 1045                 1050             


Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn 
    1055                 1060                 1065             


Phe Met  Gln Leu Ile His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp 
    1070                 1075                 1080             


Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly Asp Ser  Leu His Glu 
    1085                 1090                 1095             


His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile 
    1100                 1105                 1110             


Leu Gln  Thr Val Lys Val Val  Asp Glu Leu Val Lys  Val Met Gly 
    1115                 1120                 1125             


Arg His  Lys Pro Glu Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn 
    1130                 1135                 1140             


Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys 
    1145                 1150                 1155             


Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys 
    1160                 1165                 1170             


Glu His  Pro Val Glu Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr 
    1175                 1180                 1185             


Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu 
    1190                 1195                 1200             


Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp Val Asp  His Ile Val 
    1205                 1210                 1215             


Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu 
    1220                 1225                 1230             


Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser 
    1235                 1240                 1245             


Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu 
    1250                 1255                 1260             


Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys 
    1265                 1270                 1275             


Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile 
    1280                 1285                 1290             


Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile Thr Lys  His Val Ala 
    1295                 1300                 1305             


Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp 
    1310                 1315                 1320             


Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu 
    1325                 1330                 1335             


Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu 
    1340                 1345                 1350             


Ile Asn  Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
    1355                 1360                 1365             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1370                 1375                 1380             


Phe Val  Tyr Gly 
    1385         


<210>  283
<211>  1388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  283

Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met 
1               5                   10                  15      


Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys 
            20                  25                  30          


Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp 
        35                  40                  45              


Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln 
    50                  55                  60                  


Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys 
65                  70                  75                  80  


Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys 
                85                  90                  95      


Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val 
            100                 105                 110         


Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys 
        115                 120                 125             


Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg 
    130                 135                 140                 


Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr 
145                 150                 155                 160 


Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 
                165                 170                 175     


Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu 
            180                 185                 190         


Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe 
        195                 200                 205             


Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp 
    210                 215                 220                 


Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp 
225                 230                 235                 240 


Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala 
                245                 250                 255     


Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His Arg Asp 
            260                 265                 270         


Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu 
        275                 280                 285             


Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile 
    290                 295                 300                 


Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu 
305                 310                 315                 320 


Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser 
                325                 330                 335     


Gln Leu Gly Gly Asp Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            340                 345                 350         


Ser Gly Gly Ser Gly Gly Ser Gly Gly Met Asp Lys Lys Tyr Ser Ile 
        355                 360                 365             


Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp 
    370                 375                 380                 


Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp 
385                 390                 395                 400 


Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser 
                405                 410                 415     


Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg 
            420                 425                 430         


Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser 
        435                 440                 445             


Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu 
    450                 455                 460                 


Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe 
465                 470                 475                 480 


Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile 
                485                 490                 495     


Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu 
            500                 505                 510         


Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His 
        515                 520                 525             


Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys 
    530                 535                 540                 


Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn 
545                 550                 555                 560 


Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg 
                565                 570                 575     


Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly 
            580                 585                 590         


Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly 
        595                 600                 605             


Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys 
    610                 615                 620                 


Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu 
625                 630                 635                 640 


Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn 
                645                 650                 655     


Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu 
            660                 665                 670         


Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu 
        675                 680                 685             


His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu 
    690                 695                 700                 


Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr 
705                 710                 715                 720 


Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe 
                725                 730                 735     


Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val 
            740                 745                 750         


Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn 
        755                 760                 765             


Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu 
    770                 775                 780                 


Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys 
785                 790                 795                 800 


Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
                805                 810                 815     


Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu 
            820                 825                 830         


Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser 
        835                 840                 845             


Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro 
    850                 855                 860                 


Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr 
865                 870                 875                 880 


Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg 
                885                 890                 895     


Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu 
            900                 905                 910         


Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp 
        915                 920                 925             


Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val 
    930                 935                 940                 


Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys 
945                 950                 955                 960 


Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile 
                965                 970                 975     


Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met 
            980                 985                 990         


Ile Glu Glu Arg Leu Lys Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val 
        995                 1000                 1005             


Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr Gly Trp  Gly Arg Leu 
    1010                 1015                 1020             


Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys 
    1025                 1030                 1035             


Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn 
    1040                 1045                 1050             


Phe Met  Gln Leu Ile His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp 
    1055                 1060                 1065             


Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly Asp Ser  Leu His Glu 
    1070                 1075                 1080             


His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile 
    1085                 1090                 1095             


Leu Gln  Thr Val Lys Val Val  Asp Glu Leu Val Lys  Val Met Gly 
    1100                 1105                 1110             


Arg His  Lys Pro Glu Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn 
    1115                 1120                 1125             


Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys 
    1130                 1135                 1140             


Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys 
    1145                 1150                 1155             


Glu His  Pro Val Glu Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr 
    1160                 1165                 1170             


Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu 
    1175                 1180                 1185             


Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp Val Asp  His Ile Val 
    1190                 1195                 1200             


Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu 
    1205                 1210                 1215             


Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser 
    1220                 1225                 1230             


Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu 
    1235                 1240                 1245             


Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys 
    1250                 1255                 1260             


Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile 
    1265                 1270                 1275             


Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile Thr Lys  His Val Ala 
    1280                 1285                 1290             


Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp 
    1295                 1300                 1305             


Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu 
    1310                 1315                 1320             


Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu 
    1325                 1330                 1335             


Ile Asn  Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
    1340                 1345                 1350             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1355                 1360                 1365             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1370                 1375                 1380             


Ala Lys  Ser Glu Gln 
    1385             


<210>  284
<211>  1387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  284

Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu 
1               5                   10                  15      


Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile 
            20                  25                  30          


Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser 
        35                  40                  45              


Met Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly 
    50                  55                  60                  


Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile 
65                  70                  75                  80  


Ala Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser 
                85                  90                  95      


Pro Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly 
            100                 105                 110         


Lys Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile 
        115                 120                 125             


Met Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala 
    130                 135                 140                 


Lys Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys 
145                 150                 155                 160 


Tyr Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser 
                165                 170                 175     


Ala Gly Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr 
            180                 185                 190         


Val Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser 
        195                 200                 205             


Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His 
    210                 215                 220                 


Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val 
225                 230                 235                 240 


Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys 
                245                 250                 255     


His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu 
            260                 265                 270         


Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp 
        275                 280                 285             


Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp 
    290                 295                 300                 


Ala Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile 
305                 310                 315                 320 


Asp Leu Ser Gln Leu Gly Gly Asp Gly Gly Ser Gly Gly Ser Gly Gly 
                325                 330                 335     


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Asp Lys Lys Tyr 
            340                 345                 350         


Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile 
        355                 360                 365             


Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn 
    370                 375                 380                 


Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe 
385                 390                 395                 400 


Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg 
                405                 410                 415     


Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile 
            420                 425                 430         


Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu 
        435                 440                 445             


Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro 
    450                 455                 460                 


Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro 
465                 470                 475                 480 


Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala 
                485                 490                 495     


Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg 
            500                 505                 510         


Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val 
        515                 520                 525             


Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu 
    530                 535                 540                 


Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser 
545                 550                 555                 560 


Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu 
                565                 570                 575     


Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser 
            580                 585                 590         


Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp 
        595                 600                 605             


Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn 
    610                 615                 620                 


Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala 
625                 630                 635                 640 


Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn 
                645                 650                 655     


Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr 
            660                 665                 670         


Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln 
        675                 680                 685             


Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn 
    690                 695                 700                 


Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr 
705                 710                 715                 720 


Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu 
                725                 730                 735     


Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe 
            740                 745                 750         


Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala 
        755                 760                 765             


Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg 
    770                 775                 780                 


Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly 
785                 790                 795                 800 


Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser 
                805                 810                 815     


Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly 
            820                 825                 830         


Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn 
        835                 840                 845             


Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr 
    850                 855                 860                 


Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly 
865                 870                 875                 880 


Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val 
                885                 890                 895     


Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys 
            900                 905                 910         


Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser 
        915                 920                 925             


Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu 
    930                 935                 940                 


Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu 
945                 950                 955                 960 


Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg 
                965                 970                 975     


Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp 
            980                 985                 990         


Lys Val Met Lys Gln Leu Lys Arg  Arg Arg Tyr Thr Gly  Trp Gly Arg 
        995                 1000                 1005             


Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg Asp Lys  Gln Ser Gly 
    1010                 1015                 1020             


Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp Gly Phe  Ala Asn Arg 
    1025                 1030                 1035             


Asn Phe  Met Gln Leu Ile His  Asp Asp Ser Leu Thr  Phe Lys Glu 
    1040                 1045                 1050             


Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln Gly Asp  Ser Leu His 
    1055                 1060                 1065             


Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro Ala Ile  Lys Lys Gly 
    1070                 1075                 1080             


Ile Leu  Gln Thr Val Lys Val  Val Asp Glu Leu Val  Lys Val Met 
    1085                 1090                 1095             


Gly Arg  His Lys Pro Glu Asn  Ile Val Ile Glu Met  Ala Arg Glu 
    1100                 1105                 1110             


Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn Ser Arg  Glu Arg Met 
    1115                 1120                 1125             


Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu Gly Ser  Gln Ile Leu 
    1130                 1135                 1140             


Lys Glu  His Pro Val Glu Asn  Thr Gln Leu Gln Asn  Glu Lys Leu 
    1145                 1150                 1155             


Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
    1160                 1165                 1170             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1175                 1180                 1185             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1190                 1195                 1200             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1205                 1210                 1215             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1220                 1225                 1230             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1235                 1240                 1245             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1250                 1255                 1260             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1265                 1270                 1275             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1280                 1285                 1290             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1295                 1300                 1305             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1310                 1315                 1320             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1325                 1330                 1335             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1340                 1345                 1350             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1355                 1360                 1365             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1370                 1375                 1380             


Phe Phe  Tyr Ser 
    1385         


<210>  285
<211>  1388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  285

Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His 
1               5                   10                  15      


Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val 
            20                  25                  30          


Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys 
        35                  40                  45              


His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu 
    50                  55                  60                  


Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp 
65                  70                  75                  80  


Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp 
                85                  90                  95      


Ala Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile 
            100                 105                 110         


Asp Leu Ser Gln Leu Gly Gly Asp Gly Gly Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Met Asp Lys Lys 
    130                 135                 140                 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
145                 150                 155                 160 


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
                165                 170                 175     


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
            180                 185                 190         


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
        195                 200                 205             


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
    210                 215                 220                 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
225                 230                 235                 240 


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
                245                 250                 255     


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
            260                 265                 270         


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
        275                 280                 285             


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
    290                 295                 300                 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
305                 310                 315                 320 


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
                325                 330                 335     


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
            340                 345                 350         


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
        355                 360                 365             


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
    370                 375                 380                 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
385                 390                 395                 400 


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
                405                 410                 415     


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
            420                 425                 430         


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
        435                 440                 445             


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
    450                 455                 460                 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
465                 470                 475                 480 


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
                485                 490                 495     


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
            500                 505                 510         


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
        515                 520                 525             


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
    530                 535                 540                 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
545                 550                 555                 560 


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
                565                 570                 575     


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
            580                 585                 590         


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
        595                 600                 605             


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
    610                 615                 620                 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
625                 630                 635                 640 


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
                645                 650                 655     


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
            660                 665                 670         


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
        675                 680                 685             


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
    690                 695                 700                 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
705                 710                 715                 720 


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
                725                 730                 735     


Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn 
            740                 745                 750         


Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp 
        755                 760                 765             


Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp 
    770                 775                 780                 


Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly 
785                 790                 795                 800 


Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly 
                805                 810                 815     


Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn 
            820                 825                 830         


Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile 
        835                 840                 845             


Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile 
    850                 855                 860                 


Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr 
865                 870                 875                 880 


Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro 
                885                 890                 895     


Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys 
            900                 905                 910         


Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile 
        915                 920                 925             


Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr 
    930                 935                 940                 


Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
945                 950                 955                 960 


Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr 
                965                 970                 975     


Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile 
            980                 985                 990         


Asp Asn Lys Val Leu Thr Arg Ser  Asp Lys Asn Arg Gly  Lys Ser Asp 
        995                 1000                 1005             


Asn Val  Pro Ser Glu Glu Val  Val Lys Lys Met Lys  Asn Tyr Trp 
    1010                 1015                 1020             


Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr Gln Arg  Lys Phe Asp 
    1025                 1030                 1035             


Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu Ser Glu  Leu Asp Lys 
    1040                 1045                 1050             


Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu Thr Arg  Gln Ile Thr 
    1055                 1060                 1065             


Lys His  Val Ala Gln Ile Leu  Asp Ser Arg Met Asn  Thr Lys Tyr 
    1070                 1075                 1080             


Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val Lys Val  Ile Thr Leu 
    1085                 1090                 1095             


Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
    1100                 1105                 1110             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1115                 1120                 1125             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1130                 1135                 1140             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1145                 1150                 1155             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1160                 1165                 1170             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1175                 1180                 1185             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1190                 1195                 1200             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1205                 1210                 1215             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1220                 1225                 1230             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1235                 1240                 1245             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1250                 1255                 1260             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1265                 1270                 1275             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1280                 1285                 1290             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1295                 1300                 1305             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1310                 1315                 1320             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1325                 1330                 1335             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1340                 1345                 1350             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1355                 1360                 1365             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1370                 1375                 1380             


Lys Leu  Lys Gly Ser 
    1385             


<210>  286
<211>  1387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  286

Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu 
1               5                   10                  15      


Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile 
            20                  25                  30          


Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu 
        35                  40                  45              


Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser 
    50                  55                  60                  


Gln Leu Gly Gly Asp Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
65                  70                  75                  80  


Ser Gly Gly Ser Gly Gly Ser Gly Gly Asp Lys Lys Tyr Ser Ile Gly 
                85                  90                  95      


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
            100                 105                 110         


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
        115                 120                 125             


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
    130                 135                 140                 


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
145                 150                 155                 160 


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
                165                 170                 175     


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
            180                 185                 190         


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
        195                 200                 205             


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
    210                 215                 220                 


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
225                 230                 235                 240 


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
                245                 250                 255     


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
            260                 265                 270         


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
        275                 280                 285             


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
    290                 295                 300                 


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
305                 310                 315                 320 


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
                325                 330                 335     


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
            340                 345                 350         


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
        355                 360                 365             


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
    370                 375                 380                 


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
385                 390                 395                 400 


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
                405                 410                 415     


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
            420                 425                 430         


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
        435                 440                 445             


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
    450                 455                 460                 


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
465                 470                 475                 480 


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                485                 490                 495     


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
            500                 505                 510         


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
        515                 520                 525             


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
    530                 535                 540                 


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
545                 550                 555                 560 


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
                565                 570                 575     


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
            580                 585                 590         


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
        595                 600                 605             


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
    610                 615                 620                 


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
625                 630                 635                 640 


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
                645                 650                 655     


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
            660                 665                 670         


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
        675                 680                 685             


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
    690                 695                 700                 


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
705                 710                 715                 720 


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
                725                 730                 735     


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
            740                 745                 750         


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
        755                 760                 765             


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
    770                 775                 780                 


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
785                 790                 795                 800 


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
                805                 810                 815     


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
            820                 825                 830         


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
        835                 840                 845             


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
    850                 855                 860                 


Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly 
865                 870                 875                 880 


Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn 
                885                 890                 895     


Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val 
            900                 905                 910         


Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His 
        915                 920                 925             


Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val 
    930                 935                 940                 


Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser 
945                 950                 955                 960 


Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn 
                965                 970                 975     


Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            980                 985                 990         


Arg Gly Gly Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
        995                 1000                 1005             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1010                 1015                 1020             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1025                 1030                 1035             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1040                 1045                 1050             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1055                 1060                 1065             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1070                 1075                 1080             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1085                 1090                 1095             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1100                 1105                 1110             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1115                 1120                 1125             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1130                 1135                 1140             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1145                 1150                 1155             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1160                 1165                 1170             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1175                 1180                 1185             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1190                 1195                 1200             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1205                 1210                 1215             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1220                 1225                 1230             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1235                 1240                 1245             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1250                 1255                 1260             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1265                 1270                 1275             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1280                 1285                 1290             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1295                 1300                 1305             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1310                 1315                 1320             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1325                 1330                 1335             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1340                 1345                 1350             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1355                 1360                 1365             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1370                 1375                 1380             


Lys His  Arg Asp 
    1385         


<210>  287
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  287

Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys Ser Glu Gln 
1               5                   10                  15      


Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met 
            20                  25                  30          


Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys 
        35                  40                  45              


Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp 
    50                  55                  60                  


Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln 
65                  70                  75                  80  


Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys 
                85                  90                  95      


Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys 
            100                 105                 110         


Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val 
        115                 120                 125             


Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys 
    130                 135                 140                 


Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg 
145                 150                 155                 160 


Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr 
                165                 170                 175     


Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 
            180                 185                 190         


Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu 
        195                 200                 205             


Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe 
    210                 215                 220                 


Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp 
225                 230                 235                 240 


Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp 
                245                 250                 255     


Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala 
            260                 265                 270         


Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His Arg Asp 
        275                 280                 285             


Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu 
    290                 295                 300                 


Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile 
305                 310                 315                 320 


Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu 
                325                 330                 335     


Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser 
            340                 345                 350         


Gln Leu Gly Gly Asp 
        355         


<210>  288
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  288

Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met 
1               5                   10                  15      


Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys 
            20                  25                  30          


Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp 
        35                  40                  45              


Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln 
    50                  55                  60                  


Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys 
65                  70                  75                  80  


Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys 
                85                  90                  95      


Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val 
            100                 105                 110         


Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys 
        115                 120                 125             


Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg 
    130                 135                 140                 


Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr 
145                 150                 155                 160 


Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 
                165                 170                 175     


Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu 
            180                 185                 190         


Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe 
        195                 200                 205             


Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp 
    210                 215                 220                 


Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp 
225                 230                 235                 240 


Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala 
                245                 250                 255     


Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His Arg Asp 
            260                 265                 270         


Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu 
        275                 280                 285             


Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile 
    290                 295                 300                 


Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu 
305                 310                 315                 320 


Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser 
                325                 330                 335     


Gln Leu Gly Gly Asp 
            340     


<210>  289
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  289

Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu 
1               5                   10                  15      


Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile 
            20                  25                  30          


Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser 
        35                  40                  45              


Met Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly 
    50                  55                  60                  


Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile 
65                  70                  75                  80  


Ala Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser 
                85                  90                  95      


Pro Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly 
            100                 105                 110         


Lys Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile 
        115                 120                 125             


Met Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala 
    130                 135                 140                 


Lys Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys 
145                 150                 155                 160 


Tyr Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser 
                165                 170                 175     


Ala Gly Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr 
            180                 185                 190         


Val Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser 
        195                 200                 205             


Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His 
    210                 215                 220                 


Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val 
225                 230                 235                 240 


Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys 
                245                 250                 255     


His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu 
            260                 265                 270         


Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp 
        275                 280                 285             


Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp 
    290                 295                 300                 


Ala Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile 
305                 310                 315                 320 


Asp Leu Ser Gln Leu Gly Gly Asp 
                325             


<210>  290
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  290

Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His 
1               5                   10                  15      


Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val 
            20                  25                  30          


Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys 
        35                  40                  45              


His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu 
    50                  55                  60                  


Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp 
65                  70                  75                  80  


Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp 
                85                  90                  95      


Ala Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile 
            100                 105                 110         


Asp Leu Ser Gln Leu Gly Gly Asp 
        115                 120 


<210>  291
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  291

Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu 
1               5                   10                  15      


Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile 
            20                  25                  30          


Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu 
        35                  40                  45              


Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser 
    50                  55                  60                  


Gln Leu Gly Gly Asp 
65                  


<210>  292
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  292

Met Thr Ser Glu Lys Gly Pro Ser Thr Gly Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro Trp Glu Phe Asp Val Phe Tyr Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Ala Cys Leu Leu Tyr Glu Ile Lys Trp Gly Met Ser Arg 
        35                  40                  45              


Lys Ile Trp Arg Ser Ser Gly Lys Asn Thr Thr Asn His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Lys Lys Phe Thr Ser Glu Arg Asp Phe His Pro Ser Met 
65                  70                  75                  80  


Ser Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Trp Glu Cys 
                85                  90                  95      


Ser Gln Ala Ile Arg Glu Phe Leu Ser Arg His Pro Gly Val Thr Leu 
            100                 105                 110         


Val Ile Tyr Val Ala Arg Leu Phe Trp His Met Asp Gln Gln Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Val Asn Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Arg Ala Ser Glu Tyr Tyr His Cys Trp Arg Asn Phe Val Asn Tyr Pro 
145                 150                 155                 160 


Pro Gly Asp Glu Ala His Trp Pro Gln Tyr Pro Pro Leu Trp Met Met 
                165                 170                 175     


Leu Tyr Ala Leu Glu Leu His Cys Ile Ile Leu Ser Leu Pro Pro Cys 
            180                 185                 190         


Leu Lys Ile Ser Arg Arg Trp Gln Asn His Leu Thr Phe Phe Arg Leu 
        195                 200                 205             


His Leu Gln Asn Cys His Tyr Gln Thr Ile Pro Pro His Ile Leu Leu 
    210                 215                 220                 


Ala Thr Gly Leu Ile His Pro Ser Val Ala Trp Arg 
225                 230                 235     


<210>  293
<211>  229
<212>  PRT
<213>  Mus musculus

<400>  293

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Val Trp Arg His Thr Ser Gln Asn Thr Ser Asn His Val Glu Val 
    50                  55                  60                  


Asn Phe Leu Glu Lys Phe Thr Thr Glu Arg Tyr Phe Arg Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg His Pro Tyr Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Thr Asp Gln Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Tyr Cys Tyr Cys Trp Arg Asn Phe Val Asn Tyr Pro 
145                 150                 155                 160 


Pro Ser Asn Glu Ala Tyr Trp Pro Arg Tyr Pro His Leu Trp Val Lys 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Lys Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Thr Leu Gln Thr Cys His Tyr Gln Arg Ile Pro Pro His Leu Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys 
225                 


<210>  294
<211>  229
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus

<400>  294

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys 
225                 


<210>  295
<211>  208
<212>  PRT
<213>  Petromyzon marinus

<400>  295

Met Thr Asp Ala Glu Tyr Val Arg Ile His Glu Lys Leu Asp Ile Tyr 
1               5                   10                  15      


Thr Phe Lys Lys Gln Phe Phe Asn Asn Lys Lys Ser Val Ser His Arg 
            20                  25                  30          


Cys Tyr Val Leu Phe Glu Leu Lys Arg Arg Gly Glu Arg Arg Ala Cys 
        35                  40                  45              


Phe Trp Gly Tyr Ala Val Asn Lys Pro Gln Ser Gly Thr Glu Arg Gly 
    50                  55                  60                  


Ile His Ala Glu Ile Phe Ser Ile Arg Lys Val Glu Glu Tyr Leu Arg 
65                  70                  75                  80  


Asp Asn Pro Gly Gln Phe Thr Ile Asn Trp Tyr Ser Ser Trp Ser Pro 
                85                  90                  95      


Cys Ala Asp Cys Ala Glu Lys Ile Leu Glu Trp Tyr Asn Gln Glu Leu 
            100                 105                 110         


Arg Gly Asn Gly His Thr Leu Lys Ile Trp Ala Cys Lys Leu Tyr Tyr 
        115                 120                 125             


Glu Lys Asn Ala Arg Asn Gln Ile Gly Leu Trp Asn Leu Arg Asp Asn 
    130                 135                 140                 


Gly Val Gly Leu Asn Val Met Val Ser Glu His Tyr Gln Cys Cys Arg 
145                 150                 155                 160 


Lys Ile Phe Ile Gln Ser Ser His Asn Gln Leu Asn Glu Asn Arg Trp 
                165                 170                 175     


Leu Glu Lys Thr Leu Lys Arg Ala Glu Lys Arg Arg Ser Glu Leu Ser 
            180                 185                 190         


Ile Met Ile Gln Val Lys Ile Leu His Thr Thr Lys Ser Pro Ala Val 
        195                 200                 205             


<210>  296
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  296

Met Lys Pro His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Pro 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Glu Leu Lys Tyr 
    50                  55                  60                  


His Pro Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys Leu 
65                  70                  75                  80  


His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser Trp Ser Pro 
                85                  90                  95      


Cys Thr Lys Cys Thr Arg Asp Met Ala Thr Phe Leu Ala Glu Asp Pro 
            100                 105                 110         


Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Asp 
        115                 120                 125             


Pro Asp Tyr Gln Glu Ala Leu Arg Ser Leu Cys Gln Lys Arg Asp Gly 
    130                 135                 140                 


Pro Arg Ala Thr Met Lys Ile Met Asn Tyr Asp Glu Phe Gln His Cys 
145                 150                 155                 160 


Trp Ser Lys Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn 
                165                 170                 175     


Asn Leu Pro Lys Tyr Tyr Ile Leu Leu His Ile Met Leu Gly Glu Ile 
            180                 185                 190         


Leu Arg His Ser Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn 
        195                 200                 205             


Glu Pro Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val 
    210                 215                 220                 


Glu Arg Met His Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly 
225                 230                 235                 240 


Phe Leu Cys Asn Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg 
                245                 250                 255     


His Ala Glu Leu Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp 
            260                 265                 270         


Leu Asp Gln Asp Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys 
        275                 280                 285             


Phe Ser Cys Ala Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His 
    290                 295                 300                 


Val Ser Leu Cys Ile Phe Thr Ala Arg Ile Tyr Arg Arg Gln Gly Arg 
305                 310                 315                 320 


Cys Gln Glu Gly Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser 
                325                 330                 335     


Ile Met Thr Tyr Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp 
            340                 345                 350         


His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser 
        355                 360                 365             


Gln Asp Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Glu Asn 
    370                 375                 380                 


<210>  297
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  297

Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn Glu Pro Trp Val 
1               5                   10                  15      


Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val Glu Arg Met His 
            20                  25                  30          


Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly Phe Leu Cys Asn 
        35                  40                  45              


Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg His Ala Glu Leu 
    50                  55                  60                  


Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp Leu Asp Gln Asp 
65                  70                  75                  80  


Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys Phe Ser Cys Ala 
                85                  90                  95      


Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His Val Ser Leu Cys 
            100                 105                 110         


Ile Phe Thr Ala Arg Ile Tyr Asp Asp Gln Gly Arg Cys Gln Glu Gly 
        115                 120                 125             


Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser Ile Met Thr Tyr 
    130                 135                 140                 


Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys 
145                 150                 155                 160 


Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln Asp Leu Ser 
                165                 170                 175     


Gly Arg Leu Arg Ala Ile Leu Gln 
            180                 


<210>  298
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  298

Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn Glu Pro Trp Val 
1               5                   10                  15      


Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val Glu Arg Met His 
            20                  25                  30          


Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly Phe Leu Cys Asn 
        35                  40                  45              


Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg His Ala Glu Leu 
    50                  55                  60                  


Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp Leu Asp Gln Asp 
65                  70                  75                  80  


Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys Phe Ser Cys Ala 
                85                  90                  95      


Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His Val Ser Leu Cys 
            100                 105                 110         


Ile Phe Thr Ala Arg Ile Tyr Arg Arg Gln Gly Arg Cys Gln Glu Gly 
        115                 120                 125             


Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser Ile Met Thr Tyr 
    130                 135                 140                 


Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys 
145                 150                 155                 160 


Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln Asp Leu Ser 
                165                 170                 175     


Gly Arg Leu Arg Ala Ile Leu Gln 
            180                 


<210>  299
<211>  84
<212>  PRT
<213>  Unknown

<220>
<223>  Bacillus phage PBS2

<400>  299

Met Thr Asn Leu Ser Asp Ile Ile Glu Lys Glu Thr Gly Lys Gln Leu 
1               5                   10                  15      


Val Ile Gln Glu Ser Ile Leu Met Leu Pro Glu Glu Val Glu Glu Val 
            20                  25                  30          


Ile Gly Asn Lys Pro Glu Ser Asp Ile Leu Val His Thr Ala Tyr Asp 
        35                  40                  45              


Glu Ser Thr Asp Glu Asn Val Met Leu Leu Thr Ser Asp Ala Pro Glu 
    50                  55                  60                  


Tyr Lys Pro Trp Ala Leu Val Ile Gln Asp Ser Asn Gly Glu Asn Lys 
65                  70                  75                  80  


Ile Lys Met Leu 
                


<210>  300
<211>  181
<212>  PRT
<213>  Erwinia tasmaniensis

<400>  300

Met Ala Ser Arg Gly Val Asn Lys Val Ile Leu Val Gly Asn Leu Gly 
1               5                   10                  15      


Gln Asp Pro Glu Val Arg Tyr Met Pro Asn Gly Gly Ala Val Ala Asn 
            20                  25                  30          


Ile Thr Leu Ala Thr Ser Glu Ser Trp Arg Asp Lys Gln Thr Gly Glu 
        35                  40                  45              


Thr Lys Glu Lys Thr Glu Trp His Arg Val Val Leu Phe Gly Lys Leu 
    50                  55                  60                  


Ala Glu Val Ala Gly Glu Tyr Leu Arg Lys Gly Ser Gln Val Tyr Ile 
65                  70                  75                  80  


Glu Gly Ala Leu Gln Thr Arg Lys Trp Thr Asp Gln Ala Gly Val Glu 
                85                  90                  95      


Lys Tyr Thr Thr Glu Val Val Val Asn Val Gly Gly Thr Met Gln Met 
            100                 105                 110         


Leu Gly Gly Arg Ser Gln Gly Gly Gly Ala Ser Ala Gly Gly Gln Asn 
        115                 120                 125             


Gly Gly Ser Asn Asn Gly Trp Gly Gln Pro Gln Gln Pro Gln Gly Gly 
    130                 135                 140                 


Asn Gln Phe Ser Gly Gly Ala Gln Gln Gln Ala Arg Pro Gln Gln Gln 
145                 150                 155                 160 


Pro Gln Gln Asn Asn Ala Pro Ala Asn Asn Glu Pro Pro Ile Asp Phe 
                165                 170                 175     


Asp Asp Asp Ile Pro 
            180     


<210>  301
<211>  209
<212>  PRT
<213>  Unknown

<220>
<223>  UdgX

<400>  301

Met Ala Gly Ala Gln Asp Phe Val Pro His Thr Ala Asp Leu Ala Glu 
1               5                   10                  15      


Leu Ala Ala Ala Ala Gly Glu Cys Arg Gly Cys Gly Leu Tyr Arg Asp 
            20                  25                  30          


Ala Thr Gln Ala Val Phe Gly Ala Gly Gly Arg Ser Ala Arg Ile Met 
        35                  40                  45              


Met Ile Gly Glu Gln Pro Gly Asp Lys Glu Asp Leu Ala Gly Leu Pro 
    50                  55                  60                  


Phe Val Gly Pro Ala Gly Arg Leu Leu Asp Arg Ala Leu Glu Ala Ala 
65                  70                  75                  80  


Asp Ile Asp Arg Asp Ala Leu Tyr Val Thr Asn Ala Val Lys His Phe 
                85                  90                  95      


Lys Phe Thr Arg Ala Ala Gly Gly Lys Arg Arg Ile His Lys Thr Pro 
            100                 105                 110         


Ser Arg Thr Glu Val Val Ala Cys Arg Pro Trp Leu Ile Ala Glu Met 
        115                 120                 125             


Thr Ser Val Glu Pro Asp Val Val Val Leu Leu Gly Ala Thr Ala Ala 
    130                 135                 140                 


Lys Ala Leu Leu Gly Asn Asp Phe Arg Val Thr Gln His Arg Gly Glu 
145                 150                 155                 160 


Val Leu His Val Asp Asp Val Pro Gly Asp Pro Ala Leu Val Ala Thr 
                165                 170                 175     


Val His Pro Ser Ser Leu Leu Arg Gly Pro Lys Glu Glu Arg Glu Ser 
            180                 185                 190         


Ala Phe Ala Gly Leu Val Asp Asp Leu Arg Val Ala Ala Asp Val Arg 
        195                 200                 205             


Pro 
    


<210>  302
<211>  313
<212>  PRT
<213>  Unknown

<220>
<223>  UDG

<400>  302

Met Ile Gly Gln Lys Thr Leu Tyr Ser Phe Phe Ser Pro Ser Pro Ala 
1               5                   10                  15      


Arg Lys Arg His Ala Pro Ser Pro Glu Pro Ala Val Gln Gly Thr Gly 
            20                  25                  30          


Val Ala Gly Val Pro Glu Glu Ser Gly Asp Ala Ala Ala Ile Pro Ala 
        35                  40                  45              


Lys Lys Ala Pro Ala Gly Gln Glu Glu Pro Gly Thr Pro Pro Ser Ser 
    50                  55                  60                  


Pro Leu Ser Ala Glu Gln Leu Asp Arg Ile Gln Arg Asn Lys Ala Ala 
65                  70                  75                  80  


Ala Leu Leu Arg Leu Ala Ala Arg Asn Val Pro Val Gly Phe Gly Glu 
                85                  90                  95      


Ser Trp Lys Lys His Leu Ser Gly Glu Phe Gly Lys Pro Tyr Phe Ile 
            100                 105                 110         


Lys Leu Met Gly Phe Val Ala Glu Glu Arg Lys His Tyr Thr Val Tyr 
        115                 120                 125             


Pro Pro Pro His Gln Val Phe Thr Trp Thr Gln Met Cys Asp Ile Lys 
    130                 135                 140                 


Asp Val Lys Val Val Ile Leu Gly Gln Glu Pro Tyr His Gly Pro Asn 
145                 150                 155                 160 


Gln Ala His Gly Leu Cys Phe Ser Val Gln Arg Pro Val Pro Pro Pro 
                165                 170                 175     


Pro Ser Leu Glu Asn Ile Tyr Lys Glu Leu Ser Thr Asp Ile Glu Asp 
            180                 185                 190         


Phe Val His Pro Gly His Gly Asp Leu Ser Gly Trp Ala Lys Gln Gly 
        195                 200                 205             


Val Leu Leu Leu Asn Ala Val Leu Thr Val Arg Ala His Gln Ala Asn 
    210                 215                 220                 


Ser His Lys Glu Arg Gly Trp Glu Gln Phe Thr Asp Ala Val Val Ser 
225                 230                 235                 240 


Trp Leu Asn Gln Asn Ser Asn Gly Leu Val Phe Leu Leu Trp Gly Ser 
                245                 250                 255     


Tyr Ala Gln Lys Lys Gly Ser Ala Ile Asp Arg Lys Arg His His Val 
            260                 265                 270         


Leu Gln Thr Ala His Pro Ser Pro Leu Ser Val Tyr Arg Gly Phe Phe 
        275                 280                 285             


Gly Cys Arg His Phe Ser Lys Thr Asn Glu Leu Leu Gln Lys Ser Gly 
    290                 295                 300                 


Lys Lys Pro Ile Asp Trp Lys Glu Leu 
305                 310             


<210>  303
<211>  1633
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  303

Met Gly Ser Ser His His His His His His Met Ser Ser Glu Thr Gly 
1               5                   10                  15      


Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu 
            20                  25                  30          


Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu 
        35                  40                  45              


Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr 
    50                  55                  60                  


Ser Gln Asn Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe 
65                  70                  75                  80  


Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp 
                85                  90                  95      


Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu 
            100                 105                 110         


Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg 
        115                 120                 125             


Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu 
    130                 135                 140                 


Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly 
145                 150                 155                 160 


Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His 
                165                 170                 175     


Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu 
            180                 185                 190         


Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg 
        195                 200                 205             


Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His 
    210                 215                 220                 


Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Ser 
225                 230                 235                 240 


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Asp 
                245                 250                 255     


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
            260                 265                 270         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        275                 280                 285             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    290                 295                 300                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
305                 310                 315                 320 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                325                 330                 335     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            340                 345                 350         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        355                 360                 365             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    370                 375                 380                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
385                 390                 395                 400 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                405                 410                 415     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            420                 425                 430         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        435                 440                 445             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    450                 455                 460                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
465                 470                 475                 480 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                485                 490                 495     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            500                 505                 510         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        515                 520                 525             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    530                 535                 540                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
545                 550                 555                 560 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
                565                 570                 575     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            580                 585                 590         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        595                 600                 605             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    610                 615                 620                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
625                 630                 635                 640 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                645                 650                 655     


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
            660                 665                 670         


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
        675                 680                 685             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    690                 695                 700                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
705                 710                 715                 720 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                725                 730                 735     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            740                 745                 750         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        755                 760                 765             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    770                 775                 780                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
785                 790                 795                 800 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                805                 810                 815     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            820                 825                 830         


Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr 
        835                 840                 845             


His Asp Leu Leu Lys Leu Leu Lys Asp Lys Asp Phe Leu Asp Asn Glu 
    850                 855                 860                 


Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe 
865                 870                 875                 880 


Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu 
                885                 890                 895     


Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly 
            900                 905                 910         


Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln 
        915                 920                 925             


Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn 
    930                 935                 940                 


Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu 
945                 950                 955                 960 


Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu 
                965                 970                 975     


His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu 
            980                 985                 990         


Gln Thr Val Lys Val Val Asp Glu  Leu Val Lys Val Met  Gly Arg His 
        995                 1000                 1005             


Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr 
    1010                 1015                 1020             


Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile 
    1025                 1030                 1035             


Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His 
    1040                 1045                 1050             


Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr 
    1055                 1060                 1065             


Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp 
    1070                 1075                 1080             


Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp Ala Ile  Val Pro Gln 
    1085                 1090                 1095             


Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg 
    1100                 1105                 1110             


Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu 
    1115                 1120                 1125             


Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala 
    1130                 1135                 1140             


Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu 
    1145                 1150                 1155             


Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg 
    1160                 1165                 1170             


Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys His Val  Ala Gln Ile 
    1175                 1180                 1185             


Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu 
    1190                 1195                 1200             


Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser 
    1205                 1210                 1215             


Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn 
    1220                 1225                 1230             


Asn Tyr  His His Ala His Asp  Ala Tyr Leu Asn Ala  Val Val Gly 
    1235                 1240                 1245             


Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
    1250                 1255                 1260             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1265                 1270                 1275             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1280                 1285                 1290             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1295                 1300                 1305             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1310                 1315                 1320             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1325                 1330                 1335             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1340                 1345                 1350             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1355                 1360                 1365             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1370                 1375                 1380             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1385                 1390                 1395             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1400                 1405                 1410             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1415                 1420                 1425             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1430                 1435                 1440             


Val Lys  Lys Asp Leu Leu Leu  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1445                 1450                 1455             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1460                 1465                 1470             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1475                 1480                 1485             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1490                 1495                 1500             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1505                 1510                 1515             


Tyr Leu  Asp Glu Leu Leu Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1520                 1525                 1530             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1535                 1540                 1545             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Leu 
    1550                 1555                 1560             


Leu His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1565                 1570                 1575             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1580                 1585                 1590             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1595                 1600                 1605             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Ser 
    1610                 1615                 1620             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1625                 1630             


<210>  304
<211>  1623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  304

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Leu Leu Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Leu Leu Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


Ala Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Leu Leu  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Leu Leu Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Leu Leu His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1610                 1615                 1620             


<210>  305
<211>  1630
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  305

Met Thr Ser Glu Lys Gly Pro Ser Thr Gly Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro Trp Glu Phe Asp Val Phe Tyr Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Ala Cys Leu Leu Tyr Glu Ile Lys Trp Gly Met Ser Arg 
        35                  40                  45              


Lys Ile Trp Arg Ser Ser Gly Lys Asn Thr Thr Asn His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Lys Lys Phe Thr Ser Glu Arg Asp Phe His Pro Ser Met 
65                  70                  75                  80  


Ser Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Trp Glu Cys 
                85                  90                  95      


Ser Gln Ala Ile Arg Glu Phe Leu Ser Arg His Pro Gly Val Thr Leu 
            100                 105                 110         


Val Ile Tyr Val Ala Arg Leu Phe Trp His Met Asp Gln Gln Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Val Asn Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Arg Ala Ser Glu Tyr Tyr His Cys Trp Arg Asn Phe Val Asn Tyr Pro 
145                 150                 155                 160 


Pro Gly Asp Glu Ala His Trp Pro Gln Tyr Pro Pro Leu Trp Met Met 
                165                 170                 175     


Leu Tyr Ala Leu Glu Leu His Cys Ile Ile Leu Ser Leu Pro Pro Cys 
            180                 185                 190         


Leu Lys Ile Ser Arg Arg Trp Gln Asn His Leu Thr Phe Phe Arg Leu 
        195                 200                 205             


His Leu Gln Asn Cys His Tyr Gln Thr Ile Pro Pro His Ile Leu Leu 
    210                 215                 220                 


Ala Thr Gly Leu Ile His Pro Ser Val Ala Trp Arg Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr 
                245                 250                 255     


Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile 
            260                 265                 270         


Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn 
        275                 280                 285             


Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe 
    290                 295                 300                 


Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg 
305                 310                 315                 320 


Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile 
                325                 330                 335     


Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu 
            340                 345                 350         


Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro 
        355                 360                 365             


Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro 
    370                 375                 380                 


Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala 
385                 390                 395                 400 


Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg 
                405                 410                 415     


Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val 
            420                 425                 430         


Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu 
        435                 440                 445             


Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser 
    450                 455                 460                 


Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu 
465                 470                 475                 480 


Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser 
                485                 490                 495     


Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp 
            500                 505                 510         


Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn 
        515                 520                 525             


Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala 
    530                 535                 540                 


Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn 
545                 550                 555                 560 


Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr 
                565                 570                 575     


Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln 
            580                 585                 590         


Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn 
        595                 600                 605             


Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr 
    610                 615                 620                 


Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu 
625                 630                 635                 640 


Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe 
                645                 650                 655     


Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala 
            660                 665                 670         


Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg 
        675                 680                 685             


Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly 
    690                 695                 700                 


Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser 
705                 710                 715                 720 


Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly 
                725                 730                 735     


Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn 
            740                 745                 750         


Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr 
        755                 760                 765             


Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly 
    770                 775                 780                 


Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val 
785                 790                 795                 800 


Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys 
                805                 810                 815     


Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser 
            820                 825                 830         


Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu 
        835                 840                 845             


Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu 
    850                 855                 860                 


Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg 
865                 870                 875                 880 


Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp 
                885                 890                 895     


Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg 
            900                 905                 910         


Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys 
        915                 920                 925             


Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe 
    930                 935                 940                 


Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln 
945                 950                 955                 960 


Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala 
                965                 970                 975     


Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val 
            980                 985                 990         


Lys Val Val Asp Glu Leu Val Lys  Val Met Gly Arg His  Lys Pro Glu 
        995                 1000                 1005             


Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys 
    1010                 1015                 1020             


Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly 
    1025                 1030                 1035             


Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys Glu His  Pro Val Glu 
    1040                 1045                 1050             


Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln 
    1055                 1060                 1065             


Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg 
    1070                 1075                 1080             


Leu Ser  Asp Tyr Asp Val Asp  Ala Ile Val Pro Gln  Ser Phe Leu 
    1085                 1090                 1095             


Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys 
    1100                 1105                 1110             


Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser Glu Glu  Val Val Lys 
    1115                 1120                 1125             


Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile 
    1130                 1135                 1140             


Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly 
    1145                 1150                 1155             


Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val 
    1160                 1165                 1170             


Glu Thr  Arg Gln Ile Thr Lys  His Val Ala Gln Ile  Leu Asp Ser 
    1175                 1180                 1185             


Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu 
    1190                 1195                 1200             


Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg 
    1205                 1210                 1215             


Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His 
    1220                 1225                 1230             


His Ala  His Asp Ala Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu 
    1235                 1240                 1245             


Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp 
    1250                 1255                 1260             


Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln 
    1265                 1270                 1275             


Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile 
    1280                 1285                 1290             


Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile 
    1295                 1300                 1305             


Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile 
    1310                 1315                 1320             


Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu 
    1325                 1330                 1335             


Ser Met  Pro Gln Val Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr 
    1340                 1345                 1350             


Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp 
    1355                 1360                 1365             


Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly 
    1370                 1375                 1380             


Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser Val Leu  Val Val Ala 
    1385                 1390                 1395             


Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu 
    1400                 1405                 1410             


Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn 
    1415                 1420                 1425             


Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys 
    1430                 1435                 1440             


Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu 
    1445                 1450                 1455             


Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys 
    1460                 1465                 1470             


Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr 
    1475                 1480                 1485             


Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn 
    1490                 1495                 1500             


Glu Gln  Lys Gln Leu Phe Val  Glu Gln His Lys His  Tyr Leu Asp 
    1505                 1510                 1515             


Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu 
    1520                 1525                 1530             


Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His 
    1535                 1540                 1545             


Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu 
    1550                 1555                 1560             


Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe 
    1565                 1570                 1575             


Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val 
    1580                 1585                 1590             


Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu 
    1595                 1600                 1605             


Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser 
    1610                 1615                 1620             


Pro Lys  Lys Lys Arg Lys Val  
    1625                 1630 


<210>  306
<211>  1710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  306

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Leu Leu Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Leu Leu Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


Ala Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Leu Leu  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Leu Leu Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Leu Leu His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Leu Leu 
    1610                 1615                 1620             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1625                 1630                 1635             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1640                 1645                 1650             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1655                 1660                 1665             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1670                 1675                 1680             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1685                 1690                 1695             


Leu Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1700                 1705                 1710 


<210>  307
<211>  1710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  307

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Leu Leu Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Leu Leu Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Leu Leu  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Leu Leu Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Leu Leu His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Leu Leu 
    1610                 1615                 1620             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1625                 1630                 1635             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1640                 1645                 1650             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1655                 1660                 1665             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1670                 1675                 1680             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1685                 1690                 1695             


Leu Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1700                 1705                 1710 


<210>  308
<211>  1679
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  308

Met Thr Asp Ala Glu Tyr Val Arg Ile His Glu Lys Leu Asp Ile Tyr 
1               5                   10                  15      


Thr Phe Lys Lys Gln Phe Phe Asn Asn Lys Lys Ser Val Ser His Arg 
            20                  25                  30          


Cys Tyr Val Leu Phe Glu Leu Lys Arg Arg Gly Glu Arg Arg Ala Cys 
        35                  40                  45              


Phe Trp Gly Tyr Ala Val Asn Lys Pro Gln Ser Gly Thr Glu Arg Gly 
    50                  55                  60                  


Ile His Ala Glu Ile Phe Ser Ile Arg Lys Val Glu Glu Tyr Leu Arg 
65                  70                  75                  80  


Asp Asn Pro Gly Gln Phe Thr Ile Asn Trp Tyr Ser Ser Trp Ser Pro 
                85                  90                  95      


Cys Ala Asp Cys Ala Glu Lys Ile Leu Glu Trp Tyr Asn Gln Glu Leu 
            100                 105                 110         


Arg Gly Asn Gly His Thr Leu Lys Ile Trp Ala Cys Lys Leu Tyr Tyr 
        115                 120                 125             


Glu Lys Asn Ala Arg Asn Gln Ile Gly Leu Trp Asn Leu Arg Asp Asn 
    130                 135                 140                 


Gly Val Gly Leu Asn Val Met Val Ser Glu His Tyr Gln Cys Cys Arg 
145                 150                 155                 160 


Lys Ile Phe Ile Gln Ser Ser His Asn Gln Leu Asn Glu Asn Arg Trp 
                165                 170                 175     


Leu Glu Lys Thr Leu Lys Arg Ala Glu Lys Arg Arg Ser Glu Leu Ser 
            180                 185                 190         


Ile Met Ile Gln Val Lys Ile Leu His Thr Thr Lys Ser Pro Ala Val 
        195                 200                 205             


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
    210                 215                 220                 


Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
225                 230                 235                 240 


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
                245                 250                 255     


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
            260                 265                 270         


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
        275                 280                 285             


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
    290                 295                 300                 


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
305                 310                 315                 320 


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
                325                 330                 335     


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
            340                 345                 350         


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
        355                 360                 365             


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
    370                 375                 380                 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
385                 390                 395                 400 


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
                405                 410                 415     


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
            420                 425                 430         


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
        435                 440                 445             


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
    450                 455                 460                 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
465                 470                 475                 480 


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
                485                 490                 495     


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
            500                 505                 510         


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
        515                 520                 525             


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
    530                 535                 540                 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
545                 550                 555                 560 


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
                565                 570                 575     


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
            580                 585                 590         


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
        595                 600                 605             


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
    610                 615                 620                 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
625                 630                 635                 640 


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
                645                 650                 655     


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
            660                 665                 670         


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
        675                 680                 685             


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
    690                 695                 700                 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
705                 710                 715                 720 


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
                725                 730                 735     


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
            740                 745                 750         


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
        755                 760                 765             


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
    770                 775                 780                 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
785                 790                 795                 800 


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
                805                 810                 815     


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
            820                 825                 830         


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
        835                 840                 845             


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
    850                 855                 860                 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
865                 870                 875                 880 


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
                885                 890                 895     


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
            900                 905                 910         


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
        915                 920                 925             


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
    930                 935                 940                 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
945                 950                 955                 960 


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
                965                 970                 975     


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
            980                 985                 990         


Thr Gln Lys Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
        995                 1000                 1005             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1010                 1015                 1020             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1025                 1030                 1035             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1040                 1045                 1050             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp Ala Ile Val  Pro Gln Ser 
    1055                 1060                 1065             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1070                 1075                 1080             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1085                 1090                 1095             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1100                 1105                 1110             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    1115                 1120                 1125             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    1130                 1135                 1140             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1145                 1150                 1155             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1160                 1165                 1170             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1175                 1180                 1185             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1190                 1195                 1200             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1205                 1210                 1215             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1220                 1225                 1230             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1235                 1240                 1245             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1250                 1255                 1260             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1265                 1270                 1275             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1280                 1285                 1290             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1295                 1300                 1305             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1310                 1315                 1320             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1325                 1330                 1335             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1340                 1345                 1350             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1355                 1360                 1365             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1370                 1375                 1380             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1385                 1390                 1395             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1400                 1405                 1410             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1415                 1420                 1425             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1430                 1435                 1440             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1445                 1450                 1455             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1460                 1465                 1470             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1475                 1480                 1485             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1490                 1495                 1500             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1505                 1510                 1515             


Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile 
    1520                 1525                 1530             


His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys 
    1535                 1540                 1545             


Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys 
    1550                 1555                 1560             


Glu Val  Leu Asp Ala Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1565                 1570                 1575             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly 
    1580                 1585                 1590             


Gly Ser  Met Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1595                 1600                 1605             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1610                 1615                 1620             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1625                 1630                 1635             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1640                 1645                 1650             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1655                 1660                 1665             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu 
    1670                 1675                 


<210>  309
<211>  1689
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  309

Met Thr Asp Ala Glu Tyr Val Arg Ile His Glu Lys Leu Asp Ile Tyr 
1               5                   10                  15      


Thr Phe Lys Lys Gln Phe Phe Asn Asn Lys Lys Ser Val Ser His Arg 
            20                  25                  30          


Cys Tyr Val Leu Phe Glu Leu Lys Arg Arg Gly Glu Arg Arg Ala Cys 
        35                  40                  45              


Phe Trp Gly Tyr Ala Val Asn Lys Pro Gln Ser Gly Thr Glu Arg Gly 
    50                  55                  60                  


Ile His Ala Glu Ile Phe Ser Ile Arg Lys Val Glu Glu Tyr Leu Arg 
65                  70                  75                  80  


Asp Asn Pro Gly Gln Phe Thr Ile Asn Trp Tyr Ser Ser Trp Ser Pro 
                85                  90                  95      


Cys Ala Asp Cys Ala Glu Lys Ile Leu Glu Trp Tyr Asn Gln Glu Leu 
            100                 105                 110         


Arg Gly Asn Gly His Thr Leu Lys Ile Trp Ala Cys Lys Leu Tyr Tyr 
        115                 120                 125             


Glu Lys Asn Ala Arg Asn Gln Ile Gly Leu Trp Asn Leu Arg Asp Asn 
    130                 135                 140                 


Gly Val Gly Leu Asn Val Met Val Ser Glu His Tyr Gln Cys Cys Arg 
145                 150                 155                 160 


Lys Ile Phe Ile Gln Ser Ser His Asn Gln Leu Asn Glu Asn Arg Trp 
                165                 170                 175     


Leu Glu Lys Thr Leu Lys Arg Ala Glu Lys Arg Arg Ser Glu Leu Ser 
            180                 185                 190         


Ile Met Ile Gln Val Lys Ile Leu His Thr Thr Lys Ser Pro Ala Val 
        195                 200                 205             


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
    210                 215                 220                 


Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
225                 230                 235                 240 


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
                245                 250                 255     


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
            260                 265                 270         


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
        275                 280                 285             


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
    290                 295                 300                 


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
305                 310                 315                 320 


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
                325                 330                 335     


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
            340                 345                 350         


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
        355                 360                 365             


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
    370                 375                 380                 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
385                 390                 395                 400 


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
                405                 410                 415     


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
            420                 425                 430         


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
        435                 440                 445             


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
    450                 455                 460                 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
465                 470                 475                 480 


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
                485                 490                 495     


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
            500                 505                 510         


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
        515                 520                 525             


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
    530                 535                 540                 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
545                 550                 555                 560 


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
                565                 570                 575     


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
            580                 585                 590         


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
        595                 600                 605             


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
    610                 615                 620                 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
625                 630                 635                 640 


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
                645                 650                 655     


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
            660                 665                 670         


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
        675                 680                 685             


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
    690                 695                 700                 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
705                 710                 715                 720 


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
                725                 730                 735     


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
            740                 745                 750         


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
        755                 760                 765             


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
    770                 775                 780                 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
785                 790                 795                 800 


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
                805                 810                 815     


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
            820                 825                 830         


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
        835                 840                 845             


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
    850                 855                 860                 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
865                 870                 875                 880 


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
                885                 890                 895     


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
            900                 905                 910         


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
        915                 920                 925             


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
    930                 935                 940                 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
945                 950                 955                 960 


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
                965                 970                 975     


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
            980                 985                 990         


Thr Gln Lys Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
        995                 1000                 1005             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1010                 1015                 1020             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1025                 1030                 1035             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1040                 1045                 1050             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His Ile Val  Pro Gln Ser 
    1055                 1060                 1065             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1070                 1075                 1080             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1085                 1090                 1095             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1100                 1105                 1110             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    1115                 1120                 1125             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    1130                 1135                 1140             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1145                 1150                 1155             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1160                 1165                 1170             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1175                 1180                 1185             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1190                 1195                 1200             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1205                 1210                 1215             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1220                 1225                 1230             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1235                 1240                 1245             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1250                 1255                 1260             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1265                 1270                 1275             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1280                 1285                 1290             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1295                 1300                 1305             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1310                 1315                 1320             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1325                 1330                 1335             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1340                 1345                 1350             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1355                 1360                 1365             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1370                 1375                 1380             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1385                 1390                 1395             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1400                 1405                 1410             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1415                 1420                 1425             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1430                 1435                 1440             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1445                 1450                 1455             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1460                 1465                 1470             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1475                 1480                 1485             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1490                 1495                 1500             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1505                 1510                 1515             


Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile 
    1520                 1525                 1530             


His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys 
    1535                 1540                 1545             


Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys 
    1550                 1555                 1560             


Glu Val  Leu Asp Ala Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1565                 1570                 1575             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly 
    1580                 1585                 1590             


Gly Ser  Thr Asn Leu Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys 
    1595                 1600                 1605             


Gln Leu  Val Ile Gln Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val 
    1610                 1615                 1620             


Glu Glu  Val Ile Gly Asn Lys  Pro Glu Ser Asp Ile  Leu Val His 
    1625                 1630                 1635             


Thr Ala  Tyr Asp Glu Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr 
    1640                 1645                 1650             


Ser Asp  Ala Pro Glu Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp 
    1655                 1660                 1665             


Ser Asn  Gly Glu Asn Lys Ile  Lys Met Leu Ser Gly  Gly Ser Pro 
    1670                 1675                 1680             


Lys Lys  Lys Arg Lys Val 
    1685                 


<210>  310
<211>  1655
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  310

Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn Glu Pro Trp Val 
1               5                   10                  15      


Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val Glu Arg Met His 
            20                  25                  30          


Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly Phe Leu Cys Asn 
        35                  40                  45              


Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg His Ala Glu Leu 
    50                  55                  60                  


Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp Leu Asp Gln Asp 
65                  70                  75                  80  


Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys Phe Ser Cys Ala 
                85                  90                  95      


Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His Val Ser Leu Cys 
            100                 105                 110         


Ile Phe Thr Ala Arg Ile Tyr Asp Asp Gln Gly Arg Cys Gln Glu Gly 
        115                 120                 125             


Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser Ile Met Thr Tyr 
    130                 135                 140                 


Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys 
145                 150                 155                 160 


Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln Asp Leu Ser 
                165                 170                 175     


Gly Arg Leu Arg Ala Ile Leu Gln Ser Gly Ser Glu Thr Pro Gly Thr 
            180                 185                 190         


Ser Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu 
        195                 200                 205             


Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
    210                 215                 220                 


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
225                 230                 235                 240 


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
                245                 250                 255     


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
            260                 265                 270         


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
        275                 280                 285             


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
    290                 295                 300                 


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
305                 310                 315                 320 


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
                325                 330                 335     


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
            340                 345                 350         


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
        355                 360                 365             


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
    370                 375                 380                 


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
385                 390                 395                 400 


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
                405                 410                 415     


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
            420                 425                 430         


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
        435                 440                 445             


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
    450                 455                 460                 


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
465                 470                 475                 480 


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
                485                 490                 495     


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
            500                 505                 510         


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
        515                 520                 525             


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
    530                 535                 540                 


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
545                 550                 555                 560 


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
                565                 570                 575     


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
            580                 585                 590         


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
        595                 600                 605             


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
    610                 615                 620                 


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
625                 630                 635                 640 


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
                645                 650                 655     


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
            660                 665                 670         


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
        675                 680                 685             


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
    690                 695                 700                 


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
705                 710                 715                 720 


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
                725                 730                 735     


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
            740                 745                 750         


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
        755                 760                 765             


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
    770                 775                 780                 


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
785                 790                 795                 800 


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
                805                 810                 815     


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
            820                 825                 830         


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
        835                 840                 845             


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
    850                 855                 860                 


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
865                 870                 875                 880 


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
                885                 890                 895     


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
            900                 905                 910         


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
        915                 920                 925             


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
    930                 935                 940                 


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
945                 950                 955                 960 


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
                965                 970                 975     


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
            980                 985                 990         


Gln Ile Leu Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
        995                 1000                 1005             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1010                 1015                 1020             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1025                 1030                 1035             


Ala Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1040                 1045                 1050             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1055                 1060                 1065             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1070                 1075                 1080             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1085                 1090                 1095             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1100                 1105                 1110             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1115                 1120                 1125             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1130                 1135                 1140             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1145                 1150                 1155             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1160                 1165                 1170             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1175                 1180                 1185             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1190                 1195                 1200             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1205                 1210                 1215             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1220                 1225                 1230             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1235                 1240                 1245             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1250                 1255                 1260             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1265                 1270                 1275             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1280                 1285                 1290             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1295                 1300                 1305             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1310                 1315                 1320             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1325                 1330                 1335             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1340                 1345                 1350             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1355                 1360                 1365             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1370                 1375                 1380             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1385                 1390                 1395             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1400                 1405                 1410             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1415                 1420                 1425             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1430                 1435                 1440             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1445                 1450                 1455             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1460                 1465                 1470             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1475                 1480                 1485             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1490                 1495                 1500             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1505                 1510                 1515             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1520                 1525                 1530             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1535                 1540                 1545             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1550                 1555                 1560             


Leu Gly  Gly Asp Ser Gly Gly  Ser Met Thr Asn Leu  Ser Asp Ile 
    1565                 1570                 1575             


Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile 
    1580                 1585                 1590             


Leu Met  Leu Pro Glu Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro 
    1595                 1600                 1605             


Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp 
    1610                 1615                 1620             


Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro 
    1625                 1630                 1635             


Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys 
    1640                 1645                 1650             


Met Leu  
    1655 


<210>  311
<211>  1665
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  311

Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn Glu Pro Trp Val 
1               5                   10                  15      


Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val Glu Arg Met His 
            20                  25                  30          


Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly Phe Leu Cys Asn 
        35                  40                  45              


Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg His Ala Glu Leu 
    50                  55                  60                  


Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp Leu Asp Gln Asp 
65                  70                  75                  80  


Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys Phe Ser Cys Ala 
                85                  90                  95      


Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His Val Ser Leu Cys 
            100                 105                 110         


Ile Phe Thr Ala Arg Ile Tyr Asp Asp Gln Gly Arg Cys Gln Glu Gly 
        115                 120                 125             


Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser Ile Met Thr Tyr 
    130                 135                 140                 


Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys 
145                 150                 155                 160 


Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln Asp Leu Ser 
                165                 170                 175     


Gly Arg Leu Arg Ala Ile Leu Gln Ser Gly Ser Glu Thr Pro Gly Thr 
            180                 185                 190         


Ser Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu 
        195                 200                 205             


Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
    210                 215                 220                 


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
225                 230                 235                 240 


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
                245                 250                 255     


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
            260                 265                 270         


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
        275                 280                 285             


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
    290                 295                 300                 


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
305                 310                 315                 320 


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
                325                 330                 335     


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
            340                 345                 350         


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
        355                 360                 365             


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
    370                 375                 380                 


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
385                 390                 395                 400 


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
                405                 410                 415     


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
            420                 425                 430         


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
        435                 440                 445             


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
    450                 455                 460                 


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
465                 470                 475                 480 


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
                485                 490                 495     


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
            500                 505                 510         


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
        515                 520                 525             


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
    530                 535                 540                 


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
545                 550                 555                 560 


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
                565                 570                 575     


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
            580                 585                 590         


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
        595                 600                 605             


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
    610                 615                 620                 


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
625                 630                 635                 640 


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
                645                 650                 655     


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
            660                 665                 670         


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
        675                 680                 685             


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
    690                 695                 700                 


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
705                 710                 715                 720 


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
                725                 730                 735     


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
            740                 745                 750         


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
        755                 760                 765             


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
    770                 775                 780                 


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
785                 790                 795                 800 


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
                805                 810                 815     


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
            820                 825                 830         


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
        835                 840                 845             


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
    850                 855                 860                 


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
865                 870                 875                 880 


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
                885                 890                 895     


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
            900                 905                 910         


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
        915                 920                 925             


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
    930                 935                 940                 


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
945                 950                 955                 960 


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
                965                 970                 975     


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
            980                 985                 990         


Gln Ile Leu Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
        995                 1000                 1005             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1010                 1015                 1020             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1025                 1030                 1035             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1040                 1045                 1050             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1055                 1060                 1065             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1070                 1075                 1080             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1085                 1090                 1095             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1100                 1105                 1110             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1115                 1120                 1125             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1130                 1135                 1140             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1145                 1150                 1155             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1160                 1165                 1170             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1175                 1180                 1185             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1190                 1195                 1200             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1205                 1210                 1215             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1220                 1225                 1230             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1235                 1240                 1245             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1250                 1255                 1260             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1265                 1270                 1275             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1280                 1285                 1290             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1295                 1300                 1305             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1310                 1315                 1320             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1325                 1330                 1335             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1340                 1345                 1350             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1355                 1360                 1365             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1370                 1375                 1380             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1385                 1390                 1395             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1400                 1405                 1410             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1415                 1420                 1425             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1430                 1435                 1440             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1445                 1450                 1455             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1460                 1465                 1470             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1475                 1480                 1485             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1490                 1495                 1500             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1505                 1510                 1515             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1520                 1525                 1530             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1535                 1540                 1545             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1550                 1555                 1560             


Leu Gly  Gly Asp Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1565                 1570                 1575             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1580                 1585                 1590             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1595                 1600                 1605             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1610                 1615                 1620             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1625                 1630                 1635             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1640                 1645                 1650             


Leu Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1655                 1660                 1665 


<210>  312
<211>  1665
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  312

Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn Glu Pro Trp Val 
1               5                   10                  15      


Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val Glu Arg Met His 
            20                  25                  30          


Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly Phe Leu Cys Asn 
        35                  40                  45              


Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg His Ala Glu Leu 
    50                  55                  60                  


Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp Leu Asp Gln Asp 
65                  70                  75                  80  


Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys Phe Ser Cys Ala 
                85                  90                  95      


Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His Val Ser Leu Cys 
            100                 105                 110         


Ile Phe Thr Ala Arg Ile Tyr Arg Arg Gln Gly Arg Cys Gln Glu Gly 
        115                 120                 125             


Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser Ile Met Thr Tyr 
    130                 135                 140                 


Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys 
145                 150                 155                 160 


Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln Asp Leu Ser 
                165                 170                 175     


Gly Arg Leu Arg Ala Ile Leu Gln Ser Gly Ser Glu Thr Pro Gly Thr 
            180                 185                 190         


Ser Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu 
        195                 200                 205             


Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
    210                 215                 220                 


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
225                 230                 235                 240 


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
                245                 250                 255     


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
            260                 265                 270         


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
        275                 280                 285             


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
    290                 295                 300                 


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
305                 310                 315                 320 


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
                325                 330                 335     


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
            340                 345                 350         


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
        355                 360                 365             


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
    370                 375                 380                 


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
385                 390                 395                 400 


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
                405                 410                 415     


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
            420                 425                 430         


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
        435                 440                 445             


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
    450                 455                 460                 


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
465                 470                 475                 480 


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
                485                 490                 495     


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
            500                 505                 510         


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
        515                 520                 525             


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
    530                 535                 540                 


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
545                 550                 555                 560 


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
                565                 570                 575     


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
            580                 585                 590         


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
        595                 600                 605             


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
    610                 615                 620                 


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
625                 630                 635                 640 


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
                645                 650                 655     


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
            660                 665                 670         


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
        675                 680                 685             


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
    690                 695                 700                 


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
705                 710                 715                 720 


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
                725                 730                 735     


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
            740                 745                 750         


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
        755                 760                 765             


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
    770                 775                 780                 


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
785                 790                 795                 800 


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
                805                 810                 815     


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
            820                 825                 830         


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
        835                 840                 845             


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
    850                 855                 860                 


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
865                 870                 875                 880 


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
                885                 890                 895     


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
            900                 905                 910         


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
        915                 920                 925             


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
    930                 935                 940                 


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
945                 950                 955                 960 


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
                965                 970                 975     


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
            980                 985                 990         


Gln Ile Leu Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
        995                 1000                 1005             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1010                 1015                 1020             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1025                 1030                 1035             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1040                 1045                 1050             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1055                 1060                 1065             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1070                 1075                 1080             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1085                 1090                 1095             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1100                 1105                 1110             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1115                 1120                 1125             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1130                 1135                 1140             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1145                 1150                 1155             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1160                 1165                 1170             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1175                 1180                 1185             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1190                 1195                 1200             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1205                 1210                 1215             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1220                 1225                 1230             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1235                 1240                 1245             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1250                 1255                 1260             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1265                 1270                 1275             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1280                 1285                 1290             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1295                 1300                 1305             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1310                 1315                 1320             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1325                 1330                 1335             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1340                 1345                 1350             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1355                 1360                 1365             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1370                 1375                 1380             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1385                 1390                 1395             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1400                 1405                 1410             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1415                 1420                 1425             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1430                 1435                 1440             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1445                 1450                 1455             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1460                 1465                 1470             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1475                 1480                 1485             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1490                 1495                 1500             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1505                 1510                 1515             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1520                 1525                 1530             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1535                 1540                 1545             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1550                 1555                 1560             


Leu Gly  Gly Asp Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1565                 1570                 1575             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1580                 1585                 1590             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1595                 1600                 1605             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1610                 1615                 1620             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1625                 1630                 1635             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1640                 1645                 1650             


Leu Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1655                 1660                 1665 


<210>  313
<211>  1612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  313

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Ala Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Ala Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Ala Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Ala  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp 
    1610         


<210>  314
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  314

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  315
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  315

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  316
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  316

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Ala Arg Gly Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  317
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  317

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Ala Arg Val Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  318
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  318

Ser Glu Val Glu Phe Ser Tyr Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Ser His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  319
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  319

Ser Glu Val Glu Phe Ser Tyr Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Ser His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Asp Phe Phe Arg Met Arg Arg Gln Asp Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  320
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  320

Ser Glu Val Glu Phe Ser Tyr Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Ser His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Asp Phe Phe Arg Met Arg Arg Gln Gly Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  321
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  321

Ser Glu Val Glu Phe Ser Tyr Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Ser His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Asp Phe Phe Arg Met Arg Arg Gln Val Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  322

<400>  322
000

<210>  323
<211>  1561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  323

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Pro  Lys Lys Lys Arg Lys  Val 
    1550                 1555                 1560     


<210>  324
<211>  1561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  324

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asn Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Pro  Lys Lys Lys Arg Lys  Val 
    1550                 1555                 1560     


<210>  325
<211>  1561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  325

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Gly Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Pro  Lys Lys Lys Arg Lys  Val 
    1550                 1555                 1560     


<210>  326
<211>  1561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  326

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Val Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Pro  Lys Lys Lys Arg Lys  Val 
    1550                 1555                 1560     


<210>  327
<211>  1648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  327

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asn Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1550                 1555                 1560             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1565                 1570                 1575             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1580                 1585                 1590             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1595                 1600                 1605             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1610                 1615                 1620             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1625                 1630                 1635             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1640                 1645             


<210>  328
<211>  1648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  328

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Gly Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1550                 1555                 1560             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1565                 1570                 1575             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1580                 1585                 1590             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1595                 1600                 1605             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1610                 1615                 1620             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1625                 1630                 1635             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1640                 1645             


<210>  329
<211>  1648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  329

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Val Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1550                 1555                 1560             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1565                 1570                 1575             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1580                 1585                 1590             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1595                 1600                 1605             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1610                 1615                 1620             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1625                 1630                 1635             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1640                 1645             


<210>  330
<211>  1648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  330

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asn Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp Ala Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1550                 1555                 1560             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1565                 1570                 1575             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1580                 1585                 1590             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1595                 1600                 1605             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1610                 1615                 1620             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1625                 1630                 1635             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1640                 1645             


<210>  331
<211>  1648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  331

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Gly Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp Ala Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1550                 1555                 1560             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1565                 1570                 1575             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1580                 1585                 1590             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1595                 1600                 1605             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1610                 1615                 1620             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1625                 1630                 1635             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1640                 1645             


<210>  332
<211>  1648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  332

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Val Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp Ala Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1550                 1555                 1560             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1565                 1570                 1575             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1580                 1585                 1590             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1595                 1600                 1605             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1610                 1615                 1620             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1625                 1630                 1635             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1640                 1645             


<210>  333
<211>  1784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  333

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asn Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Lys  Gly His Leu Thr Arg  Leu Gly Leu 
    1550                 1555                 1560             


Glu Phe  Phe Asp Gln Pro Ala  Val Pro Leu Ala Arg  Ala Phe Leu 
    1565                 1570                 1575             


Gly Gln  Val Leu Val Arg Arg  Leu Pro Asn Gly Thr  Glu Leu Arg 
    1580                 1585                 1590             


Gly Arg  Ile Val Glu Thr Gln  Ala Tyr Leu Gly Pro  Glu Asp Glu 
    1595                 1600                 1605             


Ala Ala  His Ser Arg Gly Gly  Arg Gln Thr Pro Arg  Asn Arg Gly 
    1610                 1615                 1620             


Met Phe  Met Lys Pro Gly Thr  Leu Tyr Val Tyr Ile  Ile Tyr Gly 
    1625                 1630                 1635             


Met Tyr  Phe Cys Met Asn Ile  Ser Ser Gln Gly Asp  Gly Ala Cys 
    1640                 1645                 1650             


Val Leu  Leu Arg Ala Leu Glu  Pro Leu Glu Gly Leu  Glu Thr Met 
    1655                 1660                 1665             


Arg Gln  Leu Arg Ser Thr Leu  Arg Lys Gly Thr Ala  Ser Arg Val 
    1670                 1675                 1680             


Leu Lys  Asp Arg Glu Leu Cys  Ser Gly Pro Ser Lys  Leu Cys Gln 
    1685                 1690                 1695             


Ala Leu  Ala Ile Asn Lys Ser  Phe Asp Gln Arg Asp  Leu Ala Gln 
    1700                 1705                 1710             


Asp Glu  Ala Val Trp Leu Glu  Arg Gly Pro Leu Glu  Pro Ser Glu 
    1715                 1720                 1725             


Pro Ala  Val Val Ala Ala Ala  Arg Val Gly Val Gly  His Ala Gly 
    1730                 1735                 1740             


Glu Trp  Ala Arg Lys Pro Leu  Arg Phe Tyr Val Arg  Gly Ser Pro 
    1745                 1750                 1755             


Trp Val  Ser Val Val Asp Arg  Val Ala Glu Gln Asp  Thr Gln Ala 
    1760                 1765                 1770             


Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys Val 
    1775                 1780                 


<210>  334
<211>  1784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  334

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Gly Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Lys  Gly His Leu Thr Arg  Leu Gly Leu 
    1550                 1555                 1560             


Glu Phe  Phe Asp Gln Pro Ala  Val Pro Leu Ala Arg  Ala Phe Leu 
    1565                 1570                 1575             


Gly Gln  Val Leu Val Arg Arg  Leu Pro Asn Gly Thr  Glu Leu Arg 
    1580                 1585                 1590             


Gly Arg  Ile Val Glu Thr Gln  Ala Tyr Leu Gly Pro  Glu Asp Glu 
    1595                 1600                 1605             


Ala Ala  His Ser Arg Gly Gly  Arg Gln Thr Pro Arg  Asn Arg Gly 
    1610                 1615                 1620             


Met Phe  Met Lys Pro Gly Thr  Leu Tyr Val Tyr Ile  Ile Tyr Gly 
    1625                 1630                 1635             


Met Tyr  Phe Cys Met Asn Ile  Ser Ser Gln Gly Asp  Gly Ala Cys 
    1640                 1645                 1650             


Val Leu  Leu Arg Ala Leu Glu  Pro Leu Glu Gly Leu  Glu Thr Met 
    1655                 1660                 1665             


Arg Gln  Leu Arg Ser Thr Leu  Arg Lys Gly Thr Ala  Ser Arg Val 
    1670                 1675                 1680             


Leu Lys  Asp Arg Glu Leu Cys  Ser Gly Pro Ser Lys  Leu Cys Gln 
    1685                 1690                 1695             


Ala Leu  Ala Ile Asn Lys Ser  Phe Asp Gln Arg Asp  Leu Ala Gln 
    1700                 1705                 1710             


Asp Glu  Ala Val Trp Leu Glu  Arg Gly Pro Leu Glu  Pro Ser Glu 
    1715                 1720                 1725             


Pro Ala  Val Val Ala Ala Ala  Arg Val Gly Val Gly  His Ala Gly 
    1730                 1735                 1740             


Glu Trp  Ala Arg Lys Pro Leu  Arg Phe Tyr Val Arg  Gly Ser Pro 
    1745                 1750                 1755             


Trp Val  Ser Val Val Asp Arg  Val Ala Glu Gln Asp  Thr Gln Ala 
    1760                 1765                 1770             


Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys Val 
    1775                 1780                 


<210>  335
<211>  1784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  335

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Val Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Lys  Gly His Leu Thr Arg  Leu Gly Leu 
    1550                 1555                 1560             


Glu Phe  Phe Asp Gln Pro Ala  Val Pro Leu Ala Arg  Ala Phe Leu 
    1565                 1570                 1575             


Gly Gln  Val Leu Val Arg Arg  Leu Pro Asn Gly Thr  Glu Leu Arg 
    1580                 1585                 1590             


Gly Arg  Ile Val Glu Thr Gln  Ala Tyr Leu Gly Pro  Glu Asp Glu 
    1595                 1600                 1605             


Ala Ala  His Ser Arg Gly Gly  Arg Gln Thr Pro Arg  Asn Arg Gly 
    1610                 1615                 1620             


Met Phe  Met Lys Pro Gly Thr  Leu Tyr Val Tyr Ile  Ile Tyr Gly 
    1625                 1630                 1635             


Met Tyr  Phe Cys Met Asn Ile  Ser Ser Gln Gly Asp  Gly Ala Cys 
    1640                 1645                 1650             


Val Leu  Leu Arg Ala Leu Glu  Pro Leu Glu Gly Leu  Glu Thr Met 
    1655                 1660                 1665             


Arg Gln  Leu Arg Ser Thr Leu  Arg Lys Gly Thr Ala  Ser Arg Val 
    1670                 1675                 1680             


Leu Lys  Asp Arg Glu Leu Cys  Ser Gly Pro Ser Lys  Leu Cys Gln 
    1685                 1690                 1695             


Ala Leu  Ala Ile Asn Lys Ser  Phe Asp Gln Arg Asp  Leu Ala Gln 
    1700                 1705                 1710             


Asp Glu  Ala Val Trp Leu Glu  Arg Gly Pro Leu Glu  Pro Ser Glu 
    1715                 1720                 1725             


Pro Ala  Val Val Ala Ala Ala  Arg Val Gly Val Gly  His Ala Gly 
    1730                 1735                 1740             


Glu Trp  Ala Arg Lys Pro Leu  Arg Phe Tyr Val Arg  Gly Ser Pro 
    1745                 1750                 1755             


Trp Val  Ser Val Val Asp Arg  Val Ala Glu Gln Asp  Thr Gln Ala 
    1760                 1765                 1770             


Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys Val 
    1775                 1780                 


<210>  336
<211>  1787
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  336

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asn Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Asp  Leu Ala Ser Leu Arg  Ala Gln Gln 
    1550                 1555                 1560             


Ile Glu  Leu Ala Ser Ser Val  Ile Arg Glu Asp Arg  Leu Asp Lys 
    1565                 1570                 1575             


Asp Pro  Pro Asp Leu Ile Ala  Gly Ala Ala Val Gly  Phe Glu Gln 
    1580                 1585                 1590             


Gly Gly  Glu Val Thr Arg Ala  Ala Met Val Leu Leu  Lys Tyr Pro 
    1595                 1600                 1605             


Ser Leu  Glu Leu Val Glu Tyr  Lys Val Ala Arg Ile  Ala Thr Thr 
    1610                 1615                 1620             


Met Pro  Tyr Ile Pro Gly Phe  Leu Ser Phe Arg Glu  Tyr Pro Ala 
    1625                 1630                 1635             


Leu Leu  Ala Ala Trp Glu Met  Leu Ser Gln Lys Pro  Asp Leu Val 
    1640                 1645                 1650             


Phe Val  Asp Gly His Gly Ile  Ser His Pro Arg Arg  Leu Gly Val 
    1655                 1660                 1665             


Ala Ser  His Phe Gly Leu Leu  Val Asp Val Pro Thr  Ile Gly Val 
    1670                 1675                 1680             


Ala Lys  Lys Arg Leu Cys Gly  Lys Phe Glu Pro Leu  Ser Ser Glu 
    1685                 1690                 1695             


Pro Gly  Ala Leu Ala Pro Leu  Met Asp Lys Gly Glu  Gln Leu Ala 
    1700                 1705                 1710             


Trp Val  Trp Arg Ser Lys Ala  Arg Cys Asn Pro Leu  Phe Ile Ala 
    1715                 1720                 1725             


Thr Gly  His Arg Val Ser Val  Asp Ser Ala Leu Ala  Trp Val Gln 
    1730                 1735                 1740             


Arg Cys  Met Lys Gly Tyr Arg  Leu Pro Glu Pro Thr  Arg Trp Ala 
    1745                 1750                 1755             


Asp Ala  Val Ala Ser Glu Arg  Pro Ala Phe Val Arg  Tyr Thr Ala 
    1760                 1765                 1770             


Asn Gln  Pro Ser Gly Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1775                 1780                 1785         


<210>  337
<211>  1787
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  337

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Gly Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Asp  Leu Ala Ser Leu Arg  Ala Gln Gln 
    1550                 1555                 1560             


Ile Glu  Leu Ala Ser Ser Val  Ile Arg Glu Asp Arg  Leu Asp Lys 
    1565                 1570                 1575             


Asp Pro  Pro Asp Leu Ile Ala  Gly Ala Ala Val Gly  Phe Glu Gln 
    1580                 1585                 1590             


Gly Gly  Glu Val Thr Arg Ala  Ala Met Val Leu Leu  Lys Tyr Pro 
    1595                 1600                 1605             


Ser Leu  Glu Leu Val Glu Tyr  Lys Val Ala Arg Ile  Ala Thr Thr 
    1610                 1615                 1620             


Met Pro  Tyr Ile Pro Gly Phe  Leu Ser Phe Arg Glu  Tyr Pro Ala 
    1625                 1630                 1635             


Leu Leu  Ala Ala Trp Glu Met  Leu Ser Gln Lys Pro  Asp Leu Val 
    1640                 1645                 1650             


Phe Val  Asp Gly His Gly Ile  Ser His Pro Arg Arg  Leu Gly Val 
    1655                 1660                 1665             


Ala Ser  His Phe Gly Leu Leu  Val Asp Val Pro Thr  Ile Gly Val 
    1670                 1675                 1680             


Ala Lys  Lys Arg Leu Cys Gly  Lys Phe Glu Pro Leu  Ser Ser Glu 
    1685                 1690                 1695             


Pro Gly  Ala Leu Ala Pro Leu  Met Asp Lys Gly Glu  Gln Leu Ala 
    1700                 1705                 1710             


Trp Val  Trp Arg Ser Lys Ala  Arg Cys Asn Pro Leu  Phe Ile Ala 
    1715                 1720                 1725             


Thr Gly  His Arg Val Ser Val  Asp Ser Ala Leu Ala  Trp Val Gln 
    1730                 1735                 1740             


Arg Cys  Met Lys Gly Tyr Arg  Leu Pro Glu Pro Thr  Arg Trp Ala 
    1745                 1750                 1755             


Asp Ala  Val Ala Ser Glu Arg  Pro Ala Phe Val Arg  Tyr Thr Ala 
    1760                 1765                 1770             


Asn Gln  Pro Ser Gly Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1775                 1780                 1785         


<210>  338
<211>  1787
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  338

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Val Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Ser Gly Gly Ser Asp  Leu Ala Ser Leu Arg  Ala Gln Gln 
    1550                 1555                 1560             


Ile Glu  Leu Ala Ser Ser Val  Ile Arg Glu Asp Arg  Leu Asp Lys 
    1565                 1570                 1575             


Asp Pro  Pro Asp Leu Ile Ala  Gly Ala Ala Val Gly  Phe Glu Gln 
    1580                 1585                 1590             


Gly Gly  Glu Val Thr Arg Ala  Ala Met Val Leu Leu  Lys Tyr Pro 
    1595                 1600                 1605             


Ser Leu  Glu Leu Val Glu Tyr  Lys Val Ala Arg Ile  Ala Thr Thr 
    1610                 1615                 1620             


Met Pro  Tyr Ile Pro Gly Phe  Leu Ser Phe Arg Glu  Tyr Pro Ala 
    1625                 1630                 1635             


Leu Leu  Ala Ala Trp Glu Met  Leu Ser Gln Lys Pro  Asp Leu Val 
    1640                 1645                 1650             


Phe Val  Asp Gly His Gly Ile  Ser His Pro Arg Arg  Leu Gly Val 
    1655                 1660                 1665             


Ala Ser  His Phe Gly Leu Leu  Val Asp Val Pro Thr  Ile Gly Val 
    1670                 1675                 1680             


Ala Lys  Lys Arg Leu Cys Gly  Lys Phe Glu Pro Leu  Ser Ser Glu 
    1685                 1690                 1695             


Pro Gly  Ala Leu Ala Pro Leu  Met Asp Lys Gly Glu  Gln Leu Ala 
    1700                 1705                 1710             


Trp Val  Trp Arg Ser Lys Ala  Arg Cys Asn Pro Leu  Phe Ile Ala 
    1715                 1720                 1725             


Thr Gly  His Arg Val Ser Val  Asp Ser Ala Leu Ala  Trp Val Gln 
    1730                 1735                 1740             


Arg Cys  Met Lys Gly Tyr Arg  Leu Pro Glu Pro Thr  Arg Trp Ala 
    1745                 1750                 1755             


Asp Ala  Val Ala Ser Glu Arg  Pro Ala Phe Val Arg  Tyr Thr Ala 
    1760                 1765                 1770             


Asn Gln  Pro Ser Gly Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1775                 1780                 1785         


<210>  339
<211>  1550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  339

Met Ser Glu Val Glu Phe Ser Tyr Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asn Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Ser His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp Ala Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  
    1550 


<210>  340
<211>  1550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (155)..(155)
<223>  Xaa can be any naturally occurring amino acid

<400>  340

Met Ser Glu Val Glu Phe Ser Tyr Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asn Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Ser His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Xaa Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp Ala Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  
    1550 


<210>  341
<211>  1782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  341

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asn Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Gly Gly Ser Lys Gly  His Leu Thr Arg Leu  Gly Leu Glu 
    1550                 1555                 1560             


Phe Phe  Asp Gln Pro Ala Val  Pro Leu Ala Arg Ala  Phe Leu Gly 
    1565                 1570                 1575             


Gln Val  Leu Val Arg Arg Leu  Pro Asn Gly Thr Glu  Leu Arg Gly 
    1580                 1585                 1590             


Arg Ile  Val Glu Thr Gln Ala  Tyr Leu Gly Pro Glu  Asp Glu Ala 
    1595                 1600                 1605             


Ala His  Ser Arg Gly Gly Arg  Gln Thr Pro Arg Asn  Arg Gly Met 
    1610                 1615                 1620             


Phe Met  Lys Pro Gly Thr Leu  Tyr Val Tyr Ile Ile  Tyr Gly Met 
    1625                 1630                 1635             


Tyr Phe  Cys Met Asn Ile Ser  Ser Gln Gly Asp Gly  Ala Cys Val 
    1640                 1645                 1650             


Leu Leu  Arg Ala Leu Glu Pro  Leu Glu Gly Leu Glu  Thr Met Arg 
    1655                 1660                 1665             


Gln Leu  Arg Ser Thr Leu Arg  Lys Gly Thr Ala Ser  Arg Val Leu 
    1670                 1675                 1680             


Lys Asp  Arg Glu Leu Cys Ser  Gly Pro Ser Lys Leu  Cys Gln Ala 
    1685                 1690                 1695             


Leu Ala  Ile Asn Lys Ser Phe  Asp Gln Arg Asp Leu  Ala Gln Asp 
    1700                 1705                 1710             


Glu Ala  Val Trp Leu Glu Arg  Gly Pro Leu Glu Pro  Ser Glu Pro 
    1715                 1720                 1725             


Ala Val  Val Ala Ala Ala Arg  Val Gly Val Gly His  Ala Gly Glu 
    1730                 1735                 1740             


Trp Ala  Arg Lys Pro Leu Arg  Phe Tyr Val Arg Gly  Ser Pro Trp 
    1745                 1750                 1755             


Val Ser  Val Val Asp Arg Val  Ala Glu Gln Asp Thr  Gln Ala Gly 
    1760                 1765                 1770             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1775                 1780         


<210>  342
<211>  1785
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  342

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asn Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                165                 170                 175     


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            180                 185                 190         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        195                 200                 205             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    210                 215                 220                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
225                 230                 235                 240 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                245                 250                 255     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            260                 265                 270         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        275                 280                 285             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    290                 295                 300                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
305                 310                 315                 320 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                325                 330                 335     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            340                 345                 350         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        355                 360                 365             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    370                 375                 380                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
385                 390                 395                 400 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                405                 410                 415     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            420                 425                 430         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        435                 440                 445             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    450                 455                 460                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                485                 490                 495     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            500                 505                 510         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        515                 520                 525             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    530                 535                 540                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
545                 550                 555                 560 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                565                 570                 575     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            580                 585                 590         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        595                 600                 605             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    610                 615                 620                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
625                 630                 635                 640 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                645                 650                 655     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            660                 665                 670         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        675                 680                 685             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    690                 695                 700                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
705                 710                 715                 720 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                725                 730                 735     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            740                 745                 750         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        755                 760                 765             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
785                 790                 795                 800 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                805                 810                 815     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            820                 825                 830         


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
        835                 840                 845             


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
    850                 855                 860                 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
865                 870                 875                 880 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
                885                 890                 895     


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
            900                 905                 910         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
        915                 920                 925             


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
    930                 935                 940                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
945                 950                 955                 960 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                965                 970                 975     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            980                 985                 990         


Leu Tyr Leu Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
        995                 1000                 1005             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile 
    1010                 1015                 1020             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1025                 1030                 1035             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1040                 1045                 1050             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1055                 1060                 1065             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1070                 1075                 1080             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1085                 1090                 1095             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1100                 1105                 1110             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1115                 1120                 1125             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1130                 1135                 1140             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1145                 1150                 1155             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1175                 1180                 1185             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1190                 1195                 1200             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1205                 1210                 1215             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1220                 1225                 1230             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1235                 1240                 1245             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1250                 1255                 1260             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1265                 1270                 1275             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1280                 1285                 1290             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1295                 1300                 1305             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1310                 1315                 1320             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1325                 1330                 1335             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1340                 1345                 1350             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1355                 1360                 1365             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1370                 1375                 1380             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1385                 1390                 1395             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1415                 1420                 1425             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1430                 1435                 1440             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1445                 1450                 1455             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1460                 1465                 1470             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1475                 1480                 1485             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1490                 1495                 1500             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1505                 1510                 1515             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1520                 1525                 1530             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1535                 1540                 1545             


Gly Asp  Gly Gly Ser Asp Leu  Ala Ser Leu Arg Ala  Gln Gln Ile 
    1550                 1555                 1560             


Glu Leu  Ala Ser Ser Val Ile  Arg Glu Asp Arg Leu  Asp Lys Asp 
    1565                 1570                 1575             


Pro Pro  Asp Leu Ile Ala Gly  Ala Ala Val Gly Phe  Glu Gln Gly 
    1580                 1585                 1590             


Gly Glu  Val Thr Arg Ala Ala  Met Val Leu Leu Lys  Tyr Pro Ser 
    1595                 1600                 1605             


Leu Glu  Leu Val Glu Tyr Lys  Val Ala Arg Ile Ala  Thr Thr Met 
    1610                 1615                 1620             


Pro Tyr  Ile Pro Gly Phe Leu  Ser Phe Arg Glu Tyr  Pro Ala Leu 
    1625                 1630                 1635             


Leu Ala  Ala Trp Glu Met Leu  Ser Gln Lys Pro Asp  Leu Val Phe 
    1640                 1645                 1650             


Val Asp  Gly His Gly Ile Ser  His Pro Arg Arg Leu  Gly Val Ala 
    1655                 1660                 1665             


Ser His  Phe Gly Leu Leu Val  Asp Val Pro Thr Ile  Gly Val Ala 
    1670                 1675                 1680             


Lys Lys  Arg Leu Cys Gly Lys  Phe Glu Pro Leu Ser  Ser Glu Pro 
    1685                 1690                 1695             


Gly Ala  Leu Ala Pro Leu Met  Asp Lys Gly Glu Gln  Leu Ala Trp 
    1700                 1705                 1710             


Val Trp  Arg Ser Lys Ala Arg  Cys Asn Pro Leu Phe  Ile Ala Thr 
    1715                 1720                 1725             


Gly His  Arg Val Ser Val Asp  Ser Ala Leu Ala Trp  Val Gln Arg 
    1730                 1735                 1740             


Cys Met  Lys Gly Tyr Arg Leu  Pro Glu Pro Thr Arg  Trp Ala Asp 
    1745                 1750                 1755             


Ala Val  Ala Ser Glu Arg Pro  Ala Phe Val Arg Tyr  Thr Ala Asn 
    1760                 1765                 1770             


Gln Pro  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1775                 1780                 1785 


<210>  343
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  343

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser 
            20                  


<210>  344
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  344

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  345
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  345

Lys Lys Thr Glu Leu Gln Thr Thr Asn Ala Glu Asn Lys Thr Lys Lys 
1               5                   10                  15      


Leu 
    


<210>  346
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  346

Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg Gly Glu Asn Gly Arg 
1               5                   10                  15      


Lys Thr Arg 
            


<210>  347
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  347

Arg Lys Ser Gly Lys Ile Ala Ala Ile Val Val Lys Arg Pro Arg Lys 
1               5                   10                  15      


<210>  348
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  348
gaagcgcctg gcagtgtacc                                                   20


<210>  349
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  349
gacgtgcgcg gccgcctggt g                                                 21


<210>  350
<211>  305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  350
tgcctgtcat acgaaaccga gatactgaca gtagaatatg gccttctgcc aatcgggaag       60

attgtggaga aacggataga atgcacagtt tactctgtcg ataacaatgg taaatttata      120

ctcagccagt tgcccagtgg cacgaccggg gagagcagga agtattcgaa tactgtctgg      180

aggatggaag tctcattagg gccactaagg accacaaatt tatgacagtc gatggccaga      240

tgctgcctat agacgaaatc tttgagcgag agttggacct catgcgagtt gacaaccttc      300

ctaat                                                                  305


<210>  351
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  351

Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser 
            20                  25                  30          


Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His 
        35                  40                  45              


Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  


Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln 
65                  70                  75                  80  


Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg 
                85                  90                  95      


Val Asp Asn Leu Pro Asn 
            100         


<210>  352
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  352
atgatcaaga tagctacaag gaagtatctt ggcaaacaaa acgtttatga tattggagtc       60

gaaagagatc acaactttgc tctgaagaac ggattcatag cttctaat                   108


<210>  353
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  353

Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 
1               5                   10                  15      


Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 
            20                  25                  30          


Ile Ala Ser Asn 
        35      


<210>  354
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  354
tgcctgtctt atgataccga gatacttacc gttgaatatg gcttcttgcc tattggaaag       60

attgtcgaag agagaattga atgcacagta tatactgtag acaagaatgg tttcgtttac      120

acacagccca ttgctcaatg gcacaatcgc ggcgaacaag aagtatttga gtactgtctc      180

gaggatggaa gcatcatacg agcaactaaa gatcataaat tcatgaccac tgacgggcag      240

atgttgccaa tagatgagat attcgagcgg ggcttggatc tcaaacaagt ggatggattg      300

cca                                                                    303


<210>  355
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  355

Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr 
            20                  25                  30          


Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His 
        35                  40                  45              


Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  


Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln 
65                  70                  75                  80  


Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp Leu Lys Gln 
                85                  90                  95      


Val Asp Gly Leu Pro 
            100     


<210>  356
<211>  159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  356
atgaagagga ctgccgatgg atcagagttt gaatctccca agaagaagag gaaagtaaag       60

ataatatctc gaaaaagtct tggtacccaa aatgtctatg atattggagt ggagaaagat      120

cacaacttcc ttctcaagaa cggtctcgta gccagcaac                             159


<210>  357
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  357

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val 
            20                  25                  30          


Tyr Asp Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn Gly 
        35                  40                  45              


Leu Val Ala Ser Asn 
    50              


<210>  358
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  358

Gly Ser His Met Thr Asn Asp Ile Tyr Phe Met Thr Leu Ala Ile Glu 
1               5                   10                  15      


Glu Ala Lys Lys Ala Ala Gln Leu Pro Glu Val Pro Ile Gly Ala Ile 
            20                  25                  30          


Ile Thr Lys Asp Asp Glu Val Ile Ala Arg Ala His Asn Leu Arg Glu 
        35                  40                  45              


Thr Leu Gln Gln Pro Thr Ala His Ala Glu His Ile Ala Ile Glu Arg 
    50                  55                  60                  


Ala Ala Lys Val Leu Gly Ser Trp Arg Leu Glu Gly Cys Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Thr Ile Val Met Ser 
                85                  90                  95      


Arg Ile Pro Arg Val Val Tyr Gly Ala Ala Asn Pro Lys Gly Gly Cys 
            100                 105                 110         


Ser Gly Ser Leu Met Asn Leu Leu Gln Gln Ser Asn Phe Asn His Arg 
        115                 120                 125             


Ala Ile Val Asp Lys Gly Val Leu Lys Glu Ala Cys Ala Thr Leu Leu 
    130                 135                 140                 


Thr Thr Phe Phe Lys Asn Leu Arg Ala Asn Lys Lys Ser Thr Asn 
145                 150                 155                 


<210>  359
<211>  93
<212>  RNA
<213>  S. pyogenes

<400>  359
guuuaagagc uaugcuggaa agccacggug aaaaaguuca acuauugccu gaucggaaua       60

aauuugaacg auacgacagu cggugcuuuu uuu                                    93


<210>  360
<211>  82
<212>  RNA
<213>  S. pyogenes

<400>  360
guuuaagagc uagaaauagc aaguuuaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcuuuu uu                                                82


<210>  361
<211>  97
<212>  RNA
<213>  S. thermophilus

<400>  361
guuuuuguac ucucaagauu caauaaucuu gcagaagcua caaagauaag gcuucaugcc       60

gaaaucaaca cccugucauu uuauggcagg guguuuu                                97


<210>  362
<211>  1786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  362

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Phe Glu Arg Asn Tyr Asp Pro Arg Glu Leu Arg Lys Glu 
            20                  25                  30          


Thr Tyr Leu Leu Tyr Glu Ile Lys Trp Gly Lys Ser Gly Lys Leu Trp 
        35                  40                  45              


Arg His Trp Cys Gln Asn Asn Arg Thr Gln His Ala Glu Val Tyr Phe 
    50                  55                  60                  


Leu Glu Asn Ile Phe Asn Ala Arg Arg Phe Asn Pro Ser Thr His Cys 
65                  70                  75                  80  


Ser Ile Thr Trp Tyr Leu Ser Trp Ser Pro Cys Ala Glu Cys Ser Gln 
                85                  90                  95      


Lys Ile Val Asp Phe Leu Lys Glu His Pro Asn Val Asn Leu Glu Ile 
            100                 105                 110         


Tyr Val Ala Arg Leu Tyr Tyr His Glu Asp Glu Arg Asn Arg Gln Gly 
        115                 120                 125             


Leu Arg Asp Leu Val Asn Ser Gly Val Thr Ile Arg Ile Met Asp Leu 
    130                 135                 140                 


Pro Asp Tyr Asn Tyr Cys Trp Lys Thr Phe Val Ser Asp Gln Gly Gly 
145                 150                 155                 160 


Asp Glu Asp Tyr Trp Pro Gly His Phe Ala Pro Trp Ile Lys Gln Tyr 
                165                 170                 175     


Ser Leu Lys Leu Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
            180                 185                 190         


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
        195                 200                 205             


Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr 
    210                 215                 220                 


Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser 
225                 230                 235                 240 


Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys 
                245                 250                 255     


Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala 
            260                 265                 270         


Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 
        275                 280                 285             


Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val 
    290                 295                 300                 


Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 
305                 310                 315                 320 


Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu 
                325                 330                 335     


Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys 
            340                 345                 350         


Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 
        355                 360                 365             


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 
    370                 375                 380                 


Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 
385                 390                 395                 400 


Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 
                405                 410                 415     


Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 
            420                 425                 430         


Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 
        435                 440                 445             


Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys 
    450                 455                 460                 


Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 
                485                 490                 495     


Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 
            500                 505                 510         


Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 
        515                 520                 525             


Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 
    530                 535                 540                 


Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 
545                 550                 555                 560 


Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 
                565                 570                 575     


Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
            580                 585                 590         


Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp 
        595                 600                 605             


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
    610                 615                 620                 


Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 
625                 630                 635                 640 


Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
                645                 650                 655     


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
            660                 665                 670         


Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 
        675                 680                 685             


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
    690                 695                 700                 


Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro 
705                 710                 715                 720 


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
                725                 730                 735     


Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser 
            740                 745                 750         


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
        755                 760                 765             


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
    770                 775                 780                 


Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala 
785                 790                 795                 800 


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
                805                 810                 815     


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
            820                 825                 830         


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
        835                 840                 845             


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
    850                 855                 860                 


Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly 
865                 870                 875                 880 


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
                885                 890                 895     


Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
            900                 905                 910         


Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly 
        915                 920                 925             


Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile 
    930                 935                 940                 


Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys 
945                 950                 955                 960 


Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg 
                965                 970                 975     


Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met 
            980                 985                 990         


Lys Arg Ile Glu Glu Gly Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys 
        995                 1000                 1005             


Glu His  Pro Val Glu Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr 
    1010                 1015                 1020             


Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu 
    1025                 1030                 1035             


Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp Val Asp  His Ile Val 
    1040                 1045                 1050             


Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu 
    1055                 1060                 1065             


Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser 
    1070                 1075                 1080             


Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu 
    1085                 1090                 1095             


Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys 
    1100                 1105                 1110             


Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile 
    1115                 1120                 1125             


Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile Thr Lys  His Val Ala 
    1130                 1135                 1140             


Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp 
    1145                 1150                 1155             


Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu 
    1160                 1165                 1170             


Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu 
    1175                 1180                 1185             


Ile Asn  Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
    1190                 1195                 1200             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1205                 1210                 1215             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1220                 1225                 1230             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1235                 1240                 1245             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1250                 1255                 1260             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1265                 1270                 1275             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1280                 1285                 1290             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1295                 1300                 1305             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1310                 1315                 1320             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1325                 1330                 1335             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1340                 1345                 1350             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1355                 1360                 1365             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1370                 1375                 1380             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1385                 1390                 1395             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1400                 1405                 1410             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1415                 1420                 1425             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1430                 1435                 1440             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1445                 1450                 1455             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1460                 1465                 1470             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1475                 1480                 1485             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1490                 1495                 1500             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1505                 1510                 1515             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1520                 1525                 1530             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1535                 1540                 1545             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1550                 1555                 1560             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1565                 1570                 1575             


Asp Ser  Gly Gly Ser Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser 
    1580                 1585                 1590             


Asp Ile  Ile Glu Lys Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu 
    1595                 1600                 1605             


Ser Ile  Leu Met Leu Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn 
    1610                 1615                 1620             


Lys Pro  Glu Ser Asp Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser 
    1625                 1630                 1635             


Thr Asp  Glu Asn Val Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr 
    1640                 1645                 1650             


Lys Pro  Trp Ala Leu Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys 
    1655                 1660                 1665             


Ile Lys  Met Leu Ser Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Thr 
    1670                 1675                 1680             


Asn Leu  Ser Asp Ile Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val 
    1685                 1690                 1695             


Ile Gln  Glu Ser Ile Leu Met  Leu Pro Glu Glu Val  Glu Glu Val 
    1700                 1705                 1710             


Ile Gly  Asn Lys Pro Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr 
    1715                 1720                 1725             


Asp Glu  Ser Thr Asp Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala 
    1730                 1735                 1740             


Pro Glu  Tyr Lys Pro Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly 
    1745                 1750                 1755             


Glu Asn  Lys Ile Lys Met Leu  Ser Gly Gly Ser Lys  Arg Thr Ala 
    1760                 1765                 1770             


Asp Gly  Ser Glu Phe Glu Pro  Lys Lys Lys Arg Lys  Val 
    1775                 1780                 1785     


<210>  363
<211>  74
<212>  RNA
<213>  C. jejuni

<400>  363
aagaaauuua aaaagggacu aaaauaaaga guuugcggga cucugcgggg uuacaauccc       60

cuaaaaccgc uuuu                                                         74


<210>  364
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  364

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Ala Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His Leu Ala Asn Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  365
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  365

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Arg Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Val 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Arg Phe Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Arg  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Val Tyr Arg  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  366
<211>  110
<212>  RNA
<213>  M. mobile

<400>  366
uguauuucga aauacagaug uacaguuaag aauacauaag aaugauacau cacuaaaaaa       60

aggcuuuaug ccguaacuac uacuuauuuu caaaauaagu aguuuuuuuu                 110


<210>  367
<211>  1395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  367

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly 
                245                 250                 255     


Ile Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val 
            260                 265                 270         


Ile Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn 
        275                 280                 285             


Glu Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg 
    290                 295                 300                 


Arg His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu 
305                 310                 315                 320 


Leu Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg 
                325                 330                 335     


Val Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala 
            340                 345                 350         


Leu Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val 
        355                 360                 365             


Glu Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg 
    370                 375                 380                 


Asn Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu 
385                 390                 395                 400 


Arg Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys 
                405                 410                 415     


Thr Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys 
            420                 425                 430         


Ala Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu 
        435                 440                 445             


Leu Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro 
    450                 455                 460                 


Phe Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His 
465                 470                 475                 480 


Cys Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn 
                485                 490                 495     


Ala Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr 
            500                 505                 510         


Arg Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile 
        515                 520                 525             


Glu Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala 
    530                 535                 540                 


Lys Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr 
545                 550                 555                 560 


Ser Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile 
                565                 570                 575     


Lys Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu 
            580                 585                 590         


Asp Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile 
        595                 600                 605             


Gln Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile 
    610                 615                 620                 


Glu Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser 
625                 630                 635                 640 


Leu Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp 
                645                 650                 655     


Asn Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val 
            660                 665                 670         


Asp Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe 
        675                 680                 685             


Ile Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val 
    690                 695                 700                 


Ile Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile 
705                 710                 715                 720 


Glu Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn 
                725                 730                 735     


Glu Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile 
            740                 745                 750         


Ile Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile 
        755                 760                 765             


Lys Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala 
    770                 775                 780                 


Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp 
785                 790                 795                 800 


His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys 
                805                 810                 815     


Val Leu Val Lys Gln Glu Glu Ala Ser Lys Lys Gly Asn Arg Thr Pro 
            820                 825                 830         


Phe Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe 
        835                 840                 845             


Lys Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys 
    850                 855                 860                 


Thr Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser 
865                 870                 875                 880 


Val Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala 
                885                 890                 895     


Thr Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn 
            900                 905                 910         


Leu Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu 
        915                 920                 925             


Arg Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His 
    930                 935                 940                 


His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys 
945                 950                 955                 960 


Glu Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met 
                965                 970                 975     


Phe Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln 
            980                 985                 990         


Glu Tyr Lys Glu Ile Phe Ile Thr  Pro His Gln Ile Lys  His Ile Lys 
        995                 1000                 1005             


Asp Phe  Lys Asp Tyr Lys Tyr  Ser His Arg Val Asp  Lys Lys Pro 
    1010                 1015                 1020             


Asn Arg  Glu Leu Ile Asn Asp  Thr Leu Tyr Ser Thr  Arg Lys Asp 
    1025                 1030                 1035             


Asp Lys  Gly Asn Thr Leu Ile  Val Asn Asn Leu Asn  Gly Leu Tyr 
    1040                 1045                 1050             


Asp Lys  Asp Asn Asp Lys Leu  Lys Lys Leu Ile Asn  Lys Ser Pro 
    1055                 1060                 1065             


Glu Lys  Leu Leu Met Tyr His  His Asp Pro Gln Thr  Tyr Gln Lys 
    1070                 1075                 1080             


Leu Lys  Leu Ile Met Glu Gln  Tyr Gly Asp Glu Lys  Asn Pro Leu 
    1085                 1090                 1095             


Tyr Lys  Tyr Tyr Glu Glu Thr  Gly Asn Tyr Leu Thr  Lys Tyr Ser 
    1100                 1105                 1110             


Lys Lys  Asp Asn Gly Pro Val  Ile Lys Lys Ile Lys  Tyr Tyr Gly 
    1115                 1120                 1125             


Asn Lys  Leu Asn Ala His Leu  Asp Ile Thr Asp Asp  Tyr Pro Asn 
    1130                 1135                 1140             


Ser Arg  Asn Lys Val Val Lys  Leu Ser Leu Lys Pro  Tyr Arg Phe 
    1145                 1150                 1155             


Asp Val  Tyr Leu Asp Asn Gly  Val Tyr Lys Phe Val  Thr Val Lys 
    1160                 1165                 1170             


Asn Leu  Asp Val Ile Lys Lys  Glu Asn Tyr Tyr Glu  Val Asn Ser 
    1175                 1180                 1185             


Lys Cys  Tyr Glu Glu Ala Lys  Lys Leu Lys Lys Ile  Ser Asn Gln 
    1190                 1195                 1200             


Ala Glu  Phe Ile Ala Ser Phe  Tyr Asn Asn Asp Leu  Ile Lys Ile 
    1205                 1210                 1215             


Asn Gly  Glu Leu Tyr Arg Val  Ile Gly Val Asn Asn  Asp Leu Leu 
    1220                 1225                 1230             


Asn Arg  Ile Glu Val Asn Met  Ile Asp Ile Thr Tyr  Arg Glu Tyr 
    1235                 1240                 1245             


Leu Glu  Asn Met Asn Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr 
    1250                 1255                 1260             


Ile Ala  Ser Lys Thr Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile 
    1265                 1270                 1275             


Leu Gly  Asn Leu Tyr Glu Val  Lys Ser Lys Lys His  Pro Gln Ile 
    1280                 1285                 1290             


Ile Lys  Lys Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1295                 1300                 1305             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1310                 1315                 1320             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1325                 1330                 1335             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1340                 1345                 1350             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1355                 1360                 1365             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1370                 1375                 1380             


Leu Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1385                 1390                 1395 


<210>  368
<211>  89
<212>  RNA
<213>  S. pyogenes

<400>  368
guuggaacca uucaaaacag cauagcaagu uaaaauaagg cuaguccguu aucaacuuga       60

aaaaguggca ccgagucggu gcuuuuuuu                                         89


<210>  369
<211>  1539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  369

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu Gly Leu 
        275                 280                 285             


Ala Ile Gly Ile Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr 
    290                 295                 300                 


Arg Asp Val Ile Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val 
305                 310                 315                 320 


Glu Asn Asn Glu Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys 
                325                 330                 335     


Arg Arg Arg Arg His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp 
            340                 345                 350         


Tyr Asn Leu Leu Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr 
        355                 360                 365             


Glu Ala Arg Val Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe 
    370                 375                 380                 


Ser Ala Ala Leu Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val 
385                 390                 395                 400 


Asn Glu Val Glu Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln 
                405                 410                 415     


Ile Ser Arg Asn Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu 
            420                 425                 430         


Gln Leu Glu Arg Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn 
        435                 440                 445             


Arg Phe Lys Thr Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys 
    450                 455                 460                 


Val Gln Lys Ala Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr 
465                 470                 475                 480 


Ile Asp Leu Leu Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu 
                485                 490                 495     


Gly Ser Pro Phe Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu 
            500                 505                 510         


Met Gly His Cys Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr 
        515                 520                 525             


Ala Tyr Asn Ala Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu 
    530                 535                 540                 


Val Ile Thr Arg Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe 
545                 550                 555                 560 


Gln Ile Ile Glu Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys 
                565                 570                 575     


Gln Ile Ala Lys Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr 
            580                 585                 590         


Arg Val Thr Ser Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr 
        595                 600                 605             


His Asp Ile Lys Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala 
    610                 615                 620                 


Glu Leu Leu Asp Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser 
625                 630                 635                 640 


Glu Asp Ile Gln Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln 
                645                 650                 655     


Glu Glu Ile Glu Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His 
            660                 665                 670         


Asn Leu Ser Leu Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His 
        675                 680                 685             


Thr Asn Asp Asn Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro 
    690                 695                 700                 


Lys Lys Val Asp Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val 
705                 710                 715                 720 


Asp Asp Phe Ile Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser 
                725                 730                 735     


Ile Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp 
            740                 745                 750         


Ile Ile Ile Glu Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys 
        755                 760                 765             


Met Ile Asn Glu Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile 
    770                 775                 780                 


Glu Glu Ile Ile Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile 
785                 790                 795                 800 


Glu Lys Ile Lys Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser 
                805                 810                 815     


Leu Glu Ala Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr 
            820                 825                 830         


Glu Val Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe 
        835                 840                 845             


Asn Asn Lys Val Leu Val Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn 
    850                 855                 860                 


Arg Thr Pro Phe Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr 
865                 870                 875                 880 


Glu Thr Phe Lys Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg 
                885                 890                 895     


Ile Ser Lys Thr Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn 
            900                 905                 910         


Arg Phe Ser Val Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr 
        915                 920                 925             


Arg Tyr Ala Thr Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg 
    930                 935                 940                 


Val Asn Asn Leu Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr 
945                 950                 955                 960 


Ser Phe Leu Arg Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly 
                965                 970                 975     


Tyr Lys His His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe 
            980                 985                 990         


Ile Phe Lys Glu Trp Lys Lys Leu  Asp Lys Ala Lys Lys  Val Met Glu 
        995                 1000                 1005             


Asn Gln  Met Phe Glu Glu Lys  Gln Ala Glu Ser Met  Pro Glu Ile 
    1010                 1015                 1020             


Glu Thr  Glu Gln Glu Tyr Lys  Glu Ile Phe Ile Thr  Pro His Gln 
    1025                 1030                 1035             


Ile Lys  His Ile Lys Asp Phe  Lys Asp Tyr Lys Tyr  Ser His Arg 
    1040                 1045                 1050             


Val Asp  Lys Lys Pro Asn Arg  Lys Leu Ile Asn Asp  Thr Leu Tyr 
    1055                 1060                 1065             


Ser Thr  Arg Lys Asp Asp Lys  Gly Asn Thr Leu Ile  Val Asn Asn 
    1070                 1075                 1080             


Leu Asn  Gly Leu Tyr Asp Lys  Asp Asn Asp Lys Leu  Lys Lys Leu 
    1085                 1090                 1095             


Ile Asn  Lys Ser Pro Glu Lys  Leu Leu Met Tyr His  His Asp Pro 
    1100                 1105                 1110             


Gln Thr  Tyr Gln Lys Leu Lys  Leu Ile Met Glu Gln  Tyr Gly Asp 
    1115                 1120                 1125             


Glu Lys  Asn Pro Leu Tyr Lys  Tyr Tyr Glu Glu Thr  Gly Asn Tyr 
    1130                 1135                 1140             


Leu Thr  Lys Tyr Ser Lys Lys  Asp Asn Gly Pro Val  Ile Lys Lys 
    1145                 1150                 1155             


Ile Lys  Tyr Tyr Gly Asn Lys  Leu Asn Ala His Leu  Asp Ile Thr 
    1160                 1165                 1170             


Asp Asp  Tyr Pro Asn Ser Arg  Asn Lys Val Val Lys  Leu Ser Leu 
    1175                 1180                 1185             


Lys Pro  Tyr Arg Phe Asp Val  Tyr Leu Asp Asn Gly  Val Tyr Lys 
    1190                 1195                 1200             


Phe Val  Thr Val Lys Asn Leu  Asp Val Ile Lys Lys  Glu Asn Tyr 
    1205                 1210                 1215             


Tyr Glu  Val Asn Ser Lys Cys  Tyr Glu Glu Ala Lys  Lys Leu Lys 
    1220                 1225                 1230             


Lys Ile  Ser Asn Gln Ala Glu  Phe Ile Ala Ser Phe  Tyr Lys Asn 
    1235                 1240                 1245             


Asp Leu  Ile Lys Ile Asn Gly  Glu Leu Tyr Arg Val  Ile Gly Val 
    1250                 1255                 1260             


Asn Asn  Asp Leu Leu Asn Arg  Ile Glu Val Asn Met  Ile Asp Ile 
    1265                 1270                 1275             


Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn Asp Lys  Arg Pro Pro 
    1280                 1285                 1290             


His Ile  Ile Lys Thr Ile Ala  Ser Lys Thr Gln Ser  Ile Lys Lys 
    1295                 1300                 1305             


Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr Glu Val  Lys Ser Lys 
    1310                 1315                 1320             


Lys His  Pro Gln Ile Ile Lys  Lys Gly Ser Gly Gly  Ser Gly Gly 
    1325                 1330                 1335             


Ser Gly  Gly Ser Thr Asn Leu  Ser Asp Ile Ile Glu  Lys Glu Thr 
    1340                 1345                 1350             


Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile Leu Met  Leu Pro Glu 
    1355                 1360                 1365             


Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro Glu Ser  Asp Ile Leu 
    1370                 1375                 1380             


Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp Glu Asn  Val Met Leu 
    1385                 1390                 1395             


Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro Trp Ala  Leu Val Ile 
    1400                 1405                 1410             


Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys Met Leu  Ser Gly Gly 
    1415                 1420                 1425             


Ser Gly  Gly Ser Gly Gly Ser  Thr Asn Leu Ser Asp  Ile Ile Glu 
    1430                 1435                 1440             


Lys Glu  Thr Gly Lys Gln Leu  Val Ile Gln Glu Ser  Ile Leu Met 
    1445                 1450                 1455             


Leu Pro  Glu Glu Val Glu Glu  Val Ile Gly Asn Lys  Pro Glu Ser 
    1460                 1465                 1470             


Asp Ile  Leu Val His Thr Ala  Tyr Asp Glu Ser Thr  Asp Glu Asn 
    1475                 1480                 1485             


Val Met  Leu Leu Thr Ser Asp  Ala Pro Glu Tyr Lys  Pro Trp Ala 
    1490                 1495                 1500             


Leu Val  Ile Gln Asp Ser Asn  Gly Glu Asn Lys Ile  Lys Met Leu 
    1505                 1510                 1515             


Ser Gly  Gly Ser Lys Arg Thr  Ala Asp Gly Ser Glu  Phe Glu Pro 
    1520                 1525                 1530             


Lys Lys  Lys Arg Lys Val 
    1535                 


<210>  370
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  370

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Thr 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Val Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ile Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Gly Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Leu Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Gly His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Gly Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asn 
    1400                 1405                 1410             


Ser Pro  Thr Ala Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Gly 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Val Leu His Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Val Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Lys Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  371
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  371

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Val 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Gln Tyr Arg  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  372
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  372

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Val 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Arg Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Gln Tyr Arg  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  373
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  373

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  374
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  374

Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys 
            20                  25                  30  


<210>  375
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  375

Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg 
1               5                   10                  15      


Lys Val 
        


<210>  376
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  376
gcttatcgat aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa       60

ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat      120

tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta      180

tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc      240

aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt      300

ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg      360

ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc      420

ttggctgctc gcctatgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc      480

ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct      540

tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgca      600

tcgataccg                                                              609


<210>  377
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  377

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210>  378
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  378

Ser Gly Gly Ser 
1               


<210>  379
<211>  1605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  379

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1340                 1345                 1350             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1535                 1540                 1545             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Lys Arg  Thr Ala Asp 
    1580                 1585                 1590             


Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg Lys Val  
    1595                 1600                 1605 


<210>  380
<211>  1803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  380

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp 
                405                 410                 415     


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
            420                 425                 430         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        435                 440                 445             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    450                 455                 460                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
465                 470                 475                 480 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                485                 490                 495     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            500                 505                 510         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        515                 520                 525             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    530                 535                 540                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
545                 550                 555                 560 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                565                 570                 575     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            580                 585                 590         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        595                 600                 605             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    610                 615                 620                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
625                 630                 635                 640 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                645                 650                 655     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            660                 665                 670         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        675                 680                 685             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    690                 695                 700                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
705                 710                 715                 720 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
                725                 730                 735     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            740                 745                 750         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        755                 760                 765             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    770                 775                 780                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
785                 790                 795                 800 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                805                 810                 815     


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
            820                 825                 830         


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
        835                 840                 845             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    850                 855                 860                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
865                 870                 875                 880 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                885                 890                 895     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            900                 905                 910         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        915                 920                 925             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    930                 935                 940                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
945                 950                 955                 960 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                965                 970                 975     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            980                 985                 990         


Glu Ile Ser Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
        995                 1000                 1005             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1010                 1015                 1020             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1025                 1030                 1035             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1040                 1045                 1050             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Arg 
    1055                 1060                 1065             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1070                 1075                 1080             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1085                 1090                 1095             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1100                 1105                 1110             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1115                 1120                 1125             


Gly Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1130                 1135                 1140             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1145                 1150                 1155             


Asp Glu  Leu Val Lys Val Met  Gly Arg His Lys Pro  Glu Asn Ile 
    1160                 1165                 1170             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1175                 1180                 1185             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1190                 1195                 1200             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1205                 1210                 1215             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1220                 1225                 1230             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1235                 1240                 1245             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1250                 1255                 1260             


Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1265                 1270                 1275             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1280                 1285                 1290             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1295                 1300                 1305             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1310                 1315                 1320             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr 
    1325                 1330                 1335             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1340                 1345                 1350             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1355                 1360                 1365             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1370                 1375                 1380             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1385                 1390                 1395             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1400                 1405                 1410             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1415                 1420                 1425             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1430                 1435                 1440             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1445                 1450                 1455             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1460                 1465                 1470             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1475                 1480                 1485             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1490                 1495                 1500             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1505                 1510                 1515             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1520                 1525                 1530             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1535                 1540                 1545             


Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1550                 1555                 1560             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1565                 1570                 1575             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1580                 1585                 1590             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1595                 1600                 1605             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1610                 1615                 1620             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1625                 1630                 1635             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1640                 1645                 1650             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1655                 1660                 1665             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1670                 1675                 1680             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1685                 1690                 1695             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1700                 1705                 1710             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1715                 1720                 1725             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1730                 1735                 1740             


Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1745                 1750                 1755             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1760                 1765                 1770             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Ser Gly Gly  Ser Lys Arg 
    1775                 1780                 1785             


Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    1790                 1795                 1800             


<210>  381
<211>  1291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  381

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu 
    210                 215                 220                 


Gly Leu Ala Ile Gly Ile Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr 
225                 230                 235                 240 


Glu Thr Arg Asp Val Ile Asp Ala Gly Val Arg Leu Phe Lys Glu Ala 
                245                 250                 255     


Asn Val Glu Asn Asn Glu Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg 
            260                 265                 270         


Leu Lys Arg Arg Arg Arg His Arg Ile Gln Arg Val Lys Lys Leu Leu 
        275                 280                 285             


Phe Asp Tyr Asn Leu Leu Thr Asp His Ser Glu Leu Ser Gly Ile Asn 
    290                 295                 300                 


Pro Tyr Glu Ala Arg Val Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu 
305                 310                 315                 320 


Glu Phe Ser Ala Ala Leu Leu His Leu Ala Lys Arg Arg Gly Val His 
                325                 330                 335     


Asn Val Asn Glu Val Glu Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys 
            340                 345                 350         


Glu Gln Ile Ser Arg Asn Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala 
        355                 360                 365             


Glu Leu Gln Leu Glu Arg Leu Lys Lys Asp Gly Glu Val Arg Gly Ser 
    370                 375                 380                 


Ile Asn Arg Phe Lys Thr Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu 
385                 390                 395                 400 


Leu Lys Val Gln Lys Ala Tyr His Gln Leu Asp Gln Ser Phe Ile Asp 
                405                 410                 415     


Thr Tyr Ile Asp Leu Leu Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro 
            420                 425                 430         


Gly Glu Gly Ser Pro Phe Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu 
        435                 440                 445             


Met Leu Met Gly His Cys Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val 
    450                 455                 460                 


Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn 
465                 470                 475                 480 


Asn Leu Val Ile Thr Arg Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu 
                485                 490                 495     


Lys Phe Gln Ile Ile Glu Asn Val Phe Lys Gln Lys Lys Lys Pro Thr 
            500                 505                 510         


Leu Lys Gln Ile Ala Lys Glu Ile Leu Val Asn Glu Glu Asp Ile Lys 
        515                 520                 525             


Gly Tyr Arg Val Thr Ser Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys 
    530                 535                 540                 


Val Tyr His Asp Ile Lys Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu 
545                 550                 555                 560 


Asn Ala Glu Leu Leu Asp Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln 
                565                 570                 575     


Ser Ser Glu Asp Ile Gln Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu 
            580                 585                 590         


Thr Gln Glu Glu Ile Glu Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly 
        595                 600                 605             


Thr His Asn Leu Ser Leu Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu 
    610                 615                 620                 


Trp His Thr Asn Asp Asn Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu 
625                 630                 635                 640 


Val Pro Lys Lys Val Asp Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr 
                645                 650                 655     


Leu Val Asp Asp Phe Ile Leu Ser Pro Val Val Lys Arg Ser Phe Ile 
            660                 665                 670         


Gln Ser Ile Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro 
        675                 680                 685             


Asn Asp Ile Ile Ile Glu Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala 
    690                 695                 700                 


Gln Lys Met Ile Asn Glu Met Gln Lys Arg Asn Arg Gln Thr Asn Glu 
705                 710                 715                 720 


Arg Ile Glu Glu Ile Ile Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr 
                725                 730                 735     


Leu Ile Glu Lys Ile Lys Leu His Asp Met Gln Glu Gly Lys Cys Leu 
            740                 745                 750         


Tyr Ser Leu Glu Ala Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe 
        755                 760                 765             


Asn Tyr Glu Val Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn 
    770                 775                 780                 


Ser Phe Asn Asn Lys Val Leu Val Lys Gln Glu Glu Asn Ser Lys Lys 
785                 790                 795                 800 


Gly Asn Arg Thr Pro Phe Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile 
                805                 810                 815     


Ser Tyr Glu Thr Phe Lys Lys His Ile Leu Asn Leu Ala Lys Gly Lys 
            820                 825                 830         


Gly Arg Ile Ser Lys Thr Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp 
        835                 840                 845             


Ile Asn Arg Phe Ser Val Gln Lys Asp Phe Ile Asn Arg Asn Leu Val 
    850                 855                 860                 


Asp Thr Arg Tyr Ala Thr Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr 
865                 870                 875                 880 


Phe Arg Val Asn Asn Leu Asp Val Lys Val Lys Ser Ile Asn Gly Gly 
                885                 890                 895     


Phe Thr Ser Phe Leu Arg Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn 
            900                 905                 910         


Lys Gly Tyr Lys His His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala 
        915                 920                 925             


Asp Phe Ile Phe Lys Glu Trp Lys Lys Leu Asp Lys Ala Lys Lys Val 
    930                 935                 940                 


Met Glu Asn Gln Met Phe Glu Glu Lys Gln Ala Glu Ser Met Pro Glu 
945                 950                 955                 960 


Ile Glu Thr Glu Gln Glu Tyr Lys Glu Ile Phe Ile Thr Pro His Gln 
                965                 970                 975     


Ile Lys His Ile Lys Asp Phe Lys Asp Tyr Lys Tyr Ser His Arg Val 
            980                 985                 990         


Asp Lys Lys Pro Asn Arg Glu Leu  Ile Asn Asp Thr Leu  Tyr Ser Thr 
        995                 1000                 1005             


Arg Lys  Asp Asp Lys Gly Asn  Thr Leu Ile Val Asn  Asn Leu Asn 
    1010                 1015                 1020             


Gly Leu  Tyr Asp Lys Asp Asn  Asp Lys Leu Lys Lys  Leu Ile Asn 
    1025                 1030                 1035             


Lys Ser  Pro Glu Lys Leu Leu  Met Tyr His His Asp  Pro Gln Thr 
    1040                 1045                 1050             


Tyr Gln  Lys Leu Lys Leu Ile  Met Glu Gln Tyr Gly  Asp Glu Lys 
    1055                 1060                 1065             


Asn Pro  Leu Tyr Lys Tyr Tyr  Glu Glu Thr Gly Asn  Tyr Leu Thr 
    1070                 1075                 1080             


Lys Tyr  Ser Lys Lys Asp Asn  Gly Pro Val Ile Lys  Lys Ile Lys 
    1085                 1090                 1095             


Tyr Tyr  Gly Asn Lys Leu Asn  Ala His Leu Asp Ile  Thr Asp Asp 
    1100                 1105                 1110             


Tyr Pro  Asn Ser Arg Asn Lys  Val Val Lys Leu Ser  Leu Lys Pro 
    1115                 1120                 1125             


Tyr Arg  Phe Asp Val Tyr Leu  Asp Asn Gly Val Tyr  Lys Phe Val 
    1130                 1135                 1140             


Thr Val  Lys Asn Leu Asp Val  Ile Lys Lys Glu Asn  Tyr Tyr Glu 
    1145                 1150                 1155             


Val Asn  Ser Lys Cys Tyr Glu  Glu Ala Lys Lys Leu  Lys Lys Ile 
    1160                 1165                 1170             


Ser Asn  Gln Ala Glu Phe Ile  Ala Ser Phe Tyr Asn  Asn Asp Leu 
    1175                 1180                 1185             


Ile Lys  Ile Asn Gly Glu Leu  Tyr Arg Val Ile Gly  Val Asn Asn 
    1190                 1195                 1200             


Asp Leu  Leu Asn Arg Ile Glu  Val Asn Met Ile Asp  Ile Thr Tyr 
    1205                 1210                 1215             


Arg Glu  Tyr Leu Glu Asn Met  Asn Asp Lys Arg Pro  Pro Arg Ile 
    1220                 1225                 1230             


Ile Lys  Thr Ile Ala Ser Lys  Thr Gln Ser Ile Lys  Lys Tyr Ser 
    1235                 1240                 1245             


Thr Asp  Ile Leu Gly Asn Leu  Tyr Glu Val Lys Ser  Lys Lys His 
    1250                 1255                 1260             


Pro Gln  Ile Ile Lys Lys Gly  Ser Gly Gly Ser Lys  Arg Thr Ala 
    1265                 1270                 1275             


Asp Gly  Ser Glu Phe Glu Pro  Lys Lys Lys Arg Lys  Val 
    1280                 1285                 1290     


<210>  382
<211>  1605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  382

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Arg Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Val Ser Pro 
    1340                 1345                 1350             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Arg Phe  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Ala Pro Arg Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1535                 1540                 1545             


Arg Lys  Val Tyr Arg Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Lys Arg  Thr Ala Asp 
    1580                 1585                 1590             


Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg Lys Val  
    1595                 1600                 1605 


<210>  383
<211>  1291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  383

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu 
    210                 215                 220                 


Gly Leu Ala Ile Gly Ile Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr 
225                 230                 235                 240 


Glu Thr Arg Asp Val Ile Asp Ala Gly Val Arg Leu Phe Lys Glu Ala 
                245                 250                 255     


Asn Val Glu Asn Asn Glu Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg 
            260                 265                 270         


Leu Lys Arg Arg Arg Arg His Arg Ile Gln Arg Val Lys Lys Leu Leu 
        275                 280                 285             


Phe Asp Tyr Asn Leu Leu Thr Asp His Ser Glu Leu Ser Gly Ile Asn 
    290                 295                 300                 


Pro Tyr Glu Ala Arg Val Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu 
305                 310                 315                 320 


Glu Phe Ser Ala Ala Leu Leu His Leu Ala Lys Arg Arg Gly Val His 
                325                 330                 335     


Asn Val Asn Glu Val Glu Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys 
            340                 345                 350         


Glu Gln Ile Ser Arg Asn Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala 
        355                 360                 365             


Glu Leu Gln Leu Glu Arg Leu Lys Lys Asp Gly Glu Val Arg Gly Ser 
    370                 375                 380                 


Ile Asn Arg Phe Lys Thr Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu 
385                 390                 395                 400 


Leu Lys Val Gln Lys Ala Tyr His Gln Leu Asp Gln Ser Phe Ile Asp 
                405                 410                 415     


Thr Tyr Ile Asp Leu Leu Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro 
            420                 425                 430         


Gly Glu Gly Ser Pro Phe Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu 
        435                 440                 445             


Met Leu Met Gly His Cys Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val 
    450                 455                 460                 


Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn 
465                 470                 475                 480 


Asn Leu Val Ile Thr Arg Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu 
                485                 490                 495     


Lys Phe Gln Ile Ile Glu Asn Val Phe Lys Gln Lys Lys Lys Pro Thr 
            500                 505                 510         


Leu Lys Gln Ile Ala Lys Glu Ile Leu Val Asn Glu Glu Asp Ile Lys 
        515                 520                 525             


Gly Tyr Arg Val Thr Ser Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys 
    530                 535                 540                 


Val Tyr His Asp Ile Lys Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu 
545                 550                 555                 560 


Asn Ala Glu Leu Leu Asp Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln 
                565                 570                 575     


Ser Ser Glu Asp Ile Gln Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu 
            580                 585                 590         


Thr Gln Glu Glu Ile Glu Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly 
        595                 600                 605             


Thr His Asn Leu Ser Leu Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu 
    610                 615                 620                 


Trp His Thr Asn Asp Asn Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu 
625                 630                 635                 640 


Val Pro Lys Lys Val Asp Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr 
                645                 650                 655     


Leu Val Asp Asp Phe Ile Leu Ser Pro Val Val Lys Arg Ser Phe Ile 
            660                 665                 670         


Gln Ser Ile Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro 
        675                 680                 685             


Asn Asp Ile Ile Ile Glu Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala 
    690                 695                 700                 


Gln Lys Met Ile Asn Glu Met Gln Lys Arg Asn Arg Gln Thr Asn Glu 
705                 710                 715                 720 


Arg Ile Glu Glu Ile Ile Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr 
                725                 730                 735     


Leu Ile Glu Lys Ile Lys Leu His Asp Met Gln Glu Gly Lys Cys Leu 
            740                 745                 750         


Tyr Ser Leu Glu Ala Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe 
        755                 760                 765             


Asn Tyr Glu Val Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn 
    770                 775                 780                 


Ser Phe Asn Asn Lys Val Leu Val Lys Gln Glu Glu Asn Ser Lys Lys 
785                 790                 795                 800 


Gly Asn Arg Thr Pro Phe Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile 
                805                 810                 815     


Ser Tyr Glu Thr Phe Lys Lys His Ile Leu Asn Leu Ala Lys Gly Lys 
            820                 825                 830         


Gly Arg Ile Ser Lys Thr Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp 
        835                 840                 845             


Ile Asn Arg Phe Ser Val Gln Lys Asp Phe Ile Asn Arg Asn Leu Val 
    850                 855                 860                 


Asp Thr Arg Tyr Ala Thr Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr 
865                 870                 875                 880 


Phe Arg Val Asn Asn Leu Asp Val Lys Val Lys Ser Ile Asn Gly Gly 
                885                 890                 895     


Phe Thr Ser Phe Leu Arg Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn 
            900                 905                 910         


Lys Gly Tyr Lys His His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala 
        915                 920                 925             


Asp Phe Ile Phe Lys Glu Trp Lys Lys Leu Asp Lys Ala Lys Lys Val 
    930                 935                 940                 


Met Glu Asn Gln Met Phe Glu Glu Lys Gln Ala Glu Ser Met Pro Glu 
945                 950                 955                 960 


Ile Glu Thr Glu Gln Glu Tyr Lys Glu Ile Phe Ile Thr Pro His Gln 
                965                 970                 975     


Ile Lys His Ile Lys Asp Phe Lys Asp Tyr Lys Tyr Ser His Arg Val 
            980                 985                 990         


Asp Lys Lys Pro Asn Arg Lys Leu  Ile Asn Asp Thr Leu  Tyr Ser Thr 
        995                 1000                 1005             


Arg Lys  Asp Asp Lys Gly Asn  Thr Leu Ile Val Asn  Asn Leu Asn 
    1010                 1015                 1020             


Gly Leu  Tyr Asp Lys Asp Asn  Asp Lys Leu Lys Lys  Leu Ile Asn 
    1025                 1030                 1035             


Lys Ser  Pro Glu Lys Leu Leu  Met Tyr His His Asp  Pro Gln Thr 
    1040                 1045                 1050             


Tyr Gln  Lys Leu Lys Leu Ile  Met Glu Gln Tyr Gly  Asp Glu Lys 
    1055                 1060                 1065             


Asn Pro  Leu Tyr Lys Tyr Tyr  Glu Glu Thr Gly Asn  Tyr Leu Thr 
    1070                 1075                 1080             


Lys Tyr  Ser Lys Lys Asp Asn  Gly Pro Val Ile Lys  Lys Ile Lys 
    1085                 1090                 1095             


Tyr Tyr  Gly Asn Lys Leu Asn  Ala His Leu Asp Ile  Thr Asp Asp 
    1100                 1105                 1110             


Tyr Pro  Asn Ser Arg Asn Lys  Val Val Lys Leu Ser  Leu Lys Pro 
    1115                 1120                 1125             


Tyr Arg  Phe Asp Val Tyr Leu  Asp Asn Gly Val Tyr  Lys Phe Val 
    1130                 1135                 1140             


Thr Val  Lys Asn Leu Asp Val  Ile Lys Lys Glu Asn  Tyr Tyr Glu 
    1145                 1150                 1155             


Val Asn  Ser Lys Cys Tyr Glu  Glu Ala Lys Lys Leu  Lys Lys Ile 
    1160                 1165                 1170             


Ser Asn  Gln Ala Glu Phe Ile  Ala Ser Phe Tyr Lys  Asn Asp Leu 
    1175                 1180                 1185             


Ile Lys  Ile Asn Gly Glu Leu  Tyr Arg Val Ile Gly  Val Asn Asn 
    1190                 1195                 1200             


Asp Leu  Leu Asn Arg Ile Glu  Val Asn Met Ile Asp  Ile Thr Tyr 
    1205                 1210                 1215             


Arg Glu  Tyr Leu Glu Asn Met  Asn Asp Lys Arg Pro  Pro His Ile 
    1220                 1225                 1230             


Ile Lys  Thr Ile Ala Ser Lys  Thr Gln Ser Ile Lys  Lys Tyr Ser 
    1235                 1240                 1245             


Thr Asp  Ile Leu Gly Asn Leu  Tyr Glu Val Lys Ser  Lys Lys His 
    1250                 1255                 1260             


Pro Gln  Ile Ile Lys Lys Gly  Ser Gly Gly Ser Lys  Arg Thr Ala 
    1265                 1270                 1275             


Asp Gly  Ser Glu Phe Glu Pro  Lys Lys Lys Arg Lys  Val 
    1280                 1285                 1290     


<210>  384
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  384

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


<210>  385
<211>  1803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  385

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp 
                405                 410                 415     


Lys Lys Tyr Ser Ile Gly Leu Thr Ile Gly Thr Asn Ser Val Gly Trp 
            420                 425                 430         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        435                 440                 445             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    450                 455                 460                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
465                 470                 475                 480 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                485                 490                 495     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            500                 505                 510         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        515                 520                 525             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    530                 535                 540                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
545                 550                 555                 560 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                565                 570                 575     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            580                 585                 590         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        595                 600                 605             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    610                 615                 620                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
625                 630                 635                 640 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                645                 650                 655     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            660                 665                 670         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        675                 680                 685             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    690                 695                 700                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
705                 710                 715                 720 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Val 
                725                 730                 735     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            740                 745                 750         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        755                 760                 765             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    770                 775                 780                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
785                 790                 795                 800 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                805                 810                 815     


Arg Thr Phe Asp Asn Gly Ile Ile Pro His Gln Ile His Leu Gly Glu 
            820                 825                 830         


Leu His Ala Ile Leu Arg Arg Gln Gly Asp Phe Tyr Pro Phe Leu Lys 
        835                 840                 845             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    850                 855                 860                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
865                 870                 875                 880 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                885                 890                 895     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            900                 905                 910         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        915                 920                 925             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    930                 935                 940                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
945                 950                 955                 960 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                965                 970                 975     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            980                 985                 990         


Glu Ile Ser Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
        995                 1000                 1005             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1010                 1015                 1020             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1025                 1030                 1035             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1040                 1045                 1050             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Leu 
    1055                 1060                 1065             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1070                 1075                 1080             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1085                 1090                 1095             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1100                 1105                 1110             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1115                 1120                 1125             


Cys Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1130                 1135                 1140             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1145                 1150                 1155             


Asp Glu  Leu Val Lys Val Met  Gly Gly His Lys Pro  Glu Asn Ile 
    1160                 1165                 1170             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1175                 1180                 1185             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1190                 1195                 1200             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1205                 1210                 1215             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1220                 1225                 1230             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1235                 1240                 1245             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1250                 1255                 1260             


Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1265                 1270                 1275             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1280                 1285                 1290             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1295                 1300                 1305             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1310                 1315                 1320             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr 
    1325                 1330                 1335             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1340                 1345                 1350             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1355                 1360                 1365             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1370                 1375                 1380             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1385                 1390                 1395             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1400                 1405                 1410             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1415                 1420                 1425             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1430                 1435                 1440             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1445                 1450                 1455             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1460                 1465                 1470             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1475                 1480                 1485             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1490                 1495                 1500             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1505                 1510                 1515             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1520                 1525                 1530             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1535                 1540                 1545             


Asn Ser  Pro Thr Ala Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1550                 1555                 1560             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1565                 1570                 1575             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1580                 1585                 1590             


Gly Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1595                 1600                 1605             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1610                 1615                 1620             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Val Leu His  Lys Gly Asn 
    1625                 1630                 1635             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1640                 1645                 1650             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1655                 1660                 1665             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1670                 1675                 1680             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1685                 1690                 1695             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1700                 1705                 1710             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1715                 1720                 1725             


Leu Thr  Asn Leu Gly Val Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1730                 1735                 1740             


Thr Ile  Asp Lys Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1745                 1750                 1755             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1760                 1765                 1770             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Ser Gly Gly  Ser Lys Arg 
    1775                 1780                 1785             


Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    1790                 1795                 1800             


<210>  386
<211>  1786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  386

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Thr Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Leu 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ile Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Lys Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Asp Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Ile  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Val  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Glu  Gly Ala Asp Lys Arg  Thr Ala Asp 
    1760                 1765                 1770             


Gly Ser  Glu Phe Glu Ser Pro  Lys Lys Lys Arg Lys  Val 
    1775                 1780                 1785     


<210>  387
<211>  1803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  387

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp 
                405                 410                 415     


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
            420                 425                 430         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        435                 440                 445             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    450                 455                 460                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
465                 470                 475                 480 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                485                 490                 495     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            500                 505                 510         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        515                 520                 525             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    530                 535                 540                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
545                 550                 555                 560 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                565                 570                 575     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            580                 585                 590         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        595                 600                 605             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    610                 615                 620                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
625                 630                 635                 640 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                645                 650                 655     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            660                 665                 670         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        675                 680                 685             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    690                 695                 700                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
705                 710                 715                 720 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
                725                 730                 735     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            740                 745                 750         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        755                 760                 765             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    770                 775                 780                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
785                 790                 795                 800 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                805                 810                 815     


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
            820                 825                 830         


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
        835                 840                 845             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    850                 855                 860                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
865                 870                 875                 880 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                885                 890                 895     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            900                 905                 910         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        915                 920                 925             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    930                 935                 940                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
945                 950                 955                 960 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                965                 970                 975     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            980                 985                 990         


Glu Ile Ser Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
        995                 1000                 1005             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1010                 1015                 1020             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1025                 1030                 1035             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1040                 1045                 1050             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Arg 
    1055                 1060                 1065             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1070                 1075                 1080             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1085                 1090                 1095             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1100                 1105                 1110             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1115                 1120                 1125             


Gly Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1130                 1135                 1140             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1145                 1150                 1155             


Asp Glu  Leu Val Lys Val Met  Gly Arg His Lys Pro  Glu Asn Ile 
    1160                 1165                 1170             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1175                 1180                 1185             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1190                 1195                 1200             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1205                 1210                 1215             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1220                 1225                 1230             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1235                 1240                 1245             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1250                 1255                 1260             


Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1265                 1270                 1275             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1280                 1285                 1290             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1295                 1300                 1305             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1310                 1315                 1320             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr 
    1325                 1330                 1335             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1340                 1345                 1350             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1355                 1360                 1365             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1370                 1375                 1380             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1385                 1390                 1395             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1400                 1405                 1410             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1415                 1420                 1425             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1430                 1435                 1440             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1445                 1450                 1455             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1460                 1465                 1470             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1475                 1480                 1485             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1490                 1495                 1500             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1505                 1510                 1515             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1520                 1525                 1530             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1535                 1540                 1545             


Val Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1550                 1555                 1560             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1565                 1570                 1575             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1580                 1585                 1590             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1595                 1600                 1605             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1610                 1615                 1620             


Arg Lys  Arg Met Leu Ala Ser  Ala Arg Glu Leu Gln  Lys Gly Asn 
    1625                 1630                 1635             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1640                 1645                 1650             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1655                 1660                 1665             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1670                 1675                 1680             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1685                 1690                 1695             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1700                 1705                 1710             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1715                 1720                 1725             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1730                 1735                 1740             


Thr Ile  Asp Arg Lys Gln Tyr  Arg Ser Thr Lys Glu  Val Leu Asp 
    1745                 1750                 1755             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1760                 1765                 1770             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Ser Gly Gly  Ser Lys Arg 
    1775                 1780                 1785             


Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    1790                 1795                 1800             


<210>  388
<211>  1605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  388

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1340                 1345                 1350             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1535                 1540                 1545             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Lys Arg  Thr Ala Asp 
    1580                 1585                 1590             


Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg Lys Val  
    1595                 1600                 1605 


<210>  389
<211>  142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  389
ttgcccactc cctctatgcg cgctcgctcg ctcggtgggg cctgcggacc aaaggtccgc       60

agacggcaga gctctgctct gccggcccca ccgagcgagc gagcgcgcat agagggagtg      120

ggcaactcca tcactagggg ta                                               142


<210>  390
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (2)..(31)
<223>  may be absent

<400>  390

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30      


<210>  391
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  391

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


Ser Gly Gly Ser Ser Gly Gly Ser 
        35                  40  


<210>  392
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  392

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
        35                  40                  45              


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
    50                  55                  60                  


<210>  393
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  393

Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 
1               5                   10                  15      


Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 
            20                  25                  30          


Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 
        35                  40                  45              


Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 
    50                  55                  60                  


Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 
65                  70                  75                  80  


Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 
                85                  90          


<210>  394
<211>  1367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  394

Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Ala 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Ala Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Ala Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Ala Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  395
<211>  1129
<212>  PRT
<213>  Alicyclobacillus acidoterrestris

<400>  395

Met Ala Val Lys Ser Ile Lys Val Lys Leu Arg Leu Asp Asp Met Pro 
1               5                   10                  15      


Glu Ile Arg Ala Gly Leu Trp Lys Leu His Lys Glu Val Asn Ala Gly 
            20                  25                  30          


Val Arg Tyr Tyr Thr Glu Trp Leu Ser Leu Leu Arg Gln Glu Asn Leu 
        35                  40                  45              


Tyr Arg Arg Ser Pro Asn Gly Asp Gly Glu Gln Glu Cys Asp Lys Thr 
    50                  55                  60                  


Ala Glu Glu Cys Lys Ala Glu Leu Leu Glu Arg Leu Arg Ala Arg Gln 
65                  70                  75                  80  


Val Glu Asn Gly His Arg Gly Pro Ala Gly Ser Asp Asp Glu Leu Leu 
                85                  90                  95      


Gln Leu Ala Arg Gln Leu Tyr Glu Leu Leu Val Pro Gln Ala Ile Gly 
            100                 105                 110         


Ala Lys Gly Asp Ala Gln Gln Ile Ala Arg Lys Phe Leu Ser Pro Leu 
        115                 120                 125             


Ala Asp Lys Asp Ala Val Gly Gly Leu Gly Ile Ala Lys Ala Gly Asn 
    130                 135                 140                 


Lys Pro Arg Trp Val Arg Met Arg Glu Ala Gly Glu Pro Gly Trp Glu 
145                 150                 155                 160 


Glu Glu Lys Glu Lys Ala Glu Thr Arg Lys Ser Ala Asp Arg Thr Ala 
                165                 170                 175     


Asp Val Leu Arg Ala Leu Ala Asp Phe Gly Leu Lys Pro Leu Met Arg 
            180                 185                 190         


Val Tyr Thr Asp Ser Glu Met Ser Ser Val Glu Trp Lys Pro Leu Arg 
        195                 200                 205             


Lys Gly Gln Ala Val Arg Thr Trp Asp Arg Asp Met Phe Gln Gln Ala 
    210                 215                 220                 


Ile Glu Arg Met Met Ser Trp Glu Ser Trp Asn Gln Arg Val Gly Gln 
225                 230                 235                 240 


Glu Tyr Ala Lys Leu Val Glu Gln Lys Asn Arg Phe Glu Gln Lys Asn 
                245                 250                 255     


Phe Val Gly Gln Glu His Leu Val His Leu Val Asn Gln Leu Gln Gln 
            260                 265                 270         


Asp Met Lys Glu Ala Ser Pro Gly Leu Glu Ser Lys Glu Gln Thr Ala 
        275                 280                 285             


His Tyr Val Thr Gly Arg Ala Leu Arg Gly Ser Asp Lys Val Phe Glu 
    290                 295                 300                 


Lys Trp Gly Lys Leu Ala Pro Asp Ala Pro Phe Asp Leu Tyr Asp Ala 
305                 310                 315                 320 


Glu Ile Lys Asn Val Gln Arg Arg Asn Thr Arg Arg Phe Gly Ser His 
                325                 330                 335     


Asp Leu Phe Ala Lys Leu Ala Glu Pro Glu Tyr Gln Ala Leu Trp Arg 
            340                 345                 350         


Glu Asp Ala Ser Phe Leu Thr Arg Tyr Ala Val Tyr Asn Ser Ile Leu 
        355                 360                 365             


Arg Lys Leu Asn His Ala Lys Met Phe Ala Thr Phe Thr Leu Pro Asp 
    370                 375                 380                 


Ala Thr Ala His Pro Ile Trp Thr Arg Phe Asp Lys Leu Gly Gly Asn 
385                 390                 395                 400 


Leu His Gln Tyr Thr Phe Leu Phe Asn Glu Phe Gly Glu Arg Arg His 
                405                 410                 415     


Ala Ile Arg Phe His Lys Leu Leu Lys Val Glu Asn Gly Val Ala Arg 
            420                 425                 430         


Glu Val Asp Asp Val Thr Val Pro Ile Ser Met Ser Glu Gln Leu Asp 
        435                 440                 445             


Asn Leu Leu Pro Arg Asp Pro Asn Glu Pro Ile Ala Leu Tyr Phe Arg 
    450                 455                 460                 


Asp Tyr Gly Ala Glu Gln His Phe Thr Gly Glu Phe Gly Gly Ala Lys 
465                 470                 475                 480 


Ile Gln Cys Arg Arg Asp Gln Leu Ala His Met His Arg Arg Arg Gly 
                485                 490                 495     


Ala Arg Asp Val Tyr Leu Asn Val Ser Val Arg Val Gln Ser Gln Ser 
            500                 505                 510         


Glu Ala Arg Gly Glu Arg Arg Pro Pro Tyr Ala Ala Val Phe Arg Leu 
        515                 520                 525             


Val Gly Asp Asn His Arg Ala Phe Val His Phe Asp Lys Leu Ser Asp 
    530                 535                 540                 


Tyr Leu Ala Glu His Pro Asp Asp Gly Lys Leu Gly Ser Glu Gly Leu 
545                 550                 555                 560 


Leu Ser Gly Leu Arg Val Met Ser Val Asp Leu Gly Leu Arg Thr Ser 
                565                 570                 575     


Ala Ser Ile Ser Val Phe Arg Val Ala Arg Lys Asp Glu Leu Lys Pro 
            580                 585                 590         


Asn Ser Lys Gly Arg Val Pro Phe Phe Phe Pro Ile Lys Gly Asn Asp 
        595                 600                 605             


Asn Leu Val Ala Val His Glu Arg Ser Gln Leu Leu Lys Leu Pro Gly 
    610                 615                 620                 


Glu Thr Glu Ser Lys Asp Leu Arg Ala Ile Arg Glu Glu Arg Gln Arg 
625                 630                 635                 640 


Thr Leu Arg Gln Leu Arg Thr Gln Leu Ala Tyr Leu Arg Leu Leu Val 
                645                 650                 655     


Arg Cys Gly Ser Glu Asp Val Gly Arg Arg Glu Arg Ser Trp Ala Lys 
            660                 665                 670         


Leu Ile Glu Gln Pro Val Asp Ala Ala Asn His Met Thr Pro Asp Trp 
        675                 680                 685             


Arg Glu Ala Phe Glu Asn Glu Leu Gln Lys Leu Lys Ser Leu His Gly 
    690                 695                 700                 


Ile Cys Ser Asp Lys Glu Trp Met Asp Ala Val Tyr Glu Ser Val Arg 
705                 710                 715                 720 


Arg Val Trp Arg His Met Gly Lys Gln Val Arg Asp Trp Arg Lys Asp 
                725                 730                 735     


Val Arg Ser Gly Glu Arg Pro Lys Ile Arg Gly Tyr Ala Lys Asp Val 
            740                 745                 750         


Val Gly Gly Asn Ser Ile Glu Gln Ile Glu Tyr Leu Glu Arg Gln Tyr 
        755                 760                 765             


Lys Phe Leu Lys Ser Trp Ser Phe Phe Gly Lys Val Ser Gly Gln Val 
    770                 775                 780                 


Ile Arg Ala Glu Lys Gly Ser Arg Phe Ala Ile Thr Leu Arg Glu His 
785                 790                 795                 800 


Ile Asp His Ala Lys Glu Asp Arg Leu Lys Lys Leu Ala Asp Arg Ile 
                805                 810                 815     


Ile Met Glu Ala Leu Gly Tyr Val Tyr Ala Leu Asp Glu Arg Gly Lys 
            820                 825                 830         


Gly Lys Trp Val Ala Lys Tyr Pro Pro Cys Gln Leu Ile Leu Leu Glu 
        835                 840                 845             


Glu Leu Ser Glu Tyr Gln Phe Asn Asn Asp Arg Pro Pro Ser Glu Asn 
    850                 855                 860                 


Asn Gln Leu Met Gln Trp Ser His Arg Gly Val Phe Gln Glu Leu Ile 
865                 870                 875                 880 


Asn Gln Ala Gln Val His Asp Leu Leu Val Gly Thr Met Tyr Ala Ala 
                885                 890                 895     


Phe Ser Ser Arg Phe Asp Ala Arg Thr Gly Ala Pro Gly Ile Arg Cys 
            900                 905                 910         


Arg Arg Val Pro Ala Arg Cys Thr Gln Glu His Asn Pro Glu Pro Phe 
        915                 920                 925             


Pro Trp Trp Leu Asn Lys Phe Val Val Glu His Thr Leu Asp Ala Cys 
    930                 935                 940                 


Pro Leu Arg Ala Asp Asp Leu Ile Pro Thr Gly Glu Gly Glu Ile Phe 
945                 950                 955                 960 


Val Ser Pro Phe Ser Ala Glu Glu Gly Asp Phe His Gln Ile His Ala 
                965                 970                 975     


Asp Leu Asn Ala Ala Gln Asn Leu Gln Gln Arg Leu Trp Ser Asp Phe 
            980                 985                 990         


Asp Ile Ser Gln Ile Arg Leu Arg  Cys Asp Trp Gly Glu  Val Asp Gly 
        995                 1000                 1005             


Glu Leu  Val Leu Ile Pro Arg  Leu Thr Gly Lys Arg  Thr Ala Asp 
    1010                 1015                 1020             


Ser Tyr  Ser Asn Lys Val Phe  Tyr Thr Asn Thr Gly  Val Thr Tyr 
    1025                 1030                 1035             


Tyr Glu  Arg Glu Arg Gly Lys  Lys Arg Arg Lys Val  Phe Ala Gln 
    1040                 1045                 1050             


Glu Lys  Leu Ser Glu Glu Glu  Ala Glu Leu Leu Val  Glu Ala Asp 
    1055                 1060                 1065             


Glu Ala  Arg Glu Lys Ser Val  Val Leu Met Arg Asp  Pro Ser Gly 
    1070                 1075                 1080             


Ile Ile  Asn Arg Gly Asn Trp  Thr Arg Gln Lys Glu  Phe Trp Ser 
    1085                 1090                 1095             


Met Val  Asn Gln Arg Ile Glu  Gly Tyr Leu Val Lys  Gln Ile Arg 
    1100                 1105                 1110             


Ser Arg  Val Pro Leu Gln Asp  Ser Ala Cys Glu Asn  Thr Gly Asp 
    1115                 1120                 1125             


Ile 
    


<210>  396
<211>  1389
<212>  PRT
<213>  Leptotrichia shahii

<400>  396

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Arg Asp Lys 
1               5                   10                  15      


Lys Asp Phe Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Lys Phe Ile Arg Lys Tyr Ile Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Ile Leu Lys Glu Phe Thr Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Lys Glu Gly Ile Ile Arg Ile Glu Asn Asn 
                85                  90                  95      


Asp Asp Phe Leu Glu Thr Glu Glu Val Val Leu Tyr Ile Glu Ala Tyr 
            100                 105                 110         


Gly Lys Ser Glu Lys Leu Lys Ala Leu Gly Ile Thr Lys Lys Lys Ile 
        115                 120                 125             


Ile Asp Glu Ala Ile Arg Gln Gly Ile Thr Lys Asp Asp Lys Lys Ile 
    130                 135                 140                 


Glu Ile Lys Arg Gln Glu Asn Glu Glu Glu Ile Glu Ile Asp Ile Arg 
145                 150                 155                 160 


Asp Glu Tyr Thr Asn Lys Thr Leu Asn Asp Cys Ser Ile Ile Leu Arg 
                165                 170                 175     


Ile Ile Glu Asn Asp Glu Leu Glu Thr Lys Lys Ser Ile Tyr Glu Ile 
            180                 185                 190         


Phe Lys Asn Ile Asn Met Ser Leu Tyr Lys Ile Ile Glu Lys Ile Ile 
        195                 200                 205             


Glu Asn Glu Thr Glu Lys Val Phe Glu Asn Arg Tyr Tyr Glu Glu His 
    210                 215                 220                 


Leu Arg Glu Lys Leu Leu Lys Asp Asp Lys Ile Asp Val Ile Leu Thr 
225                 230                 235                 240 


Asn Phe Met Glu Ile Arg Glu Lys Ile Lys Ser Asn Leu Glu Ile Leu 
                245                 250                 255     


Gly Phe Val Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser 
            260                 265                 270         


Lys Asn Lys Lys Met Leu Val Glu Lys Ile Leu Asn Ile Asn Val Asp 
        275                 280                 285             


Leu Thr Val Glu Asp Ile Ala Asp Phe Val Ile Lys Glu Leu Glu Phe 
    290                 295                 300                 


Trp Asn Ile Thr Lys Arg Ile Glu Lys Val Lys Lys Val Asn Asn Glu 
305                 310                 315                 320 


Phe Leu Glu Lys Arg Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu 
                325                 330                 335     


Leu Asp Lys His Glu Lys Phe Lys Ile Glu Arg Glu Asn Lys Lys Asp 
            340                 345                 350         


Lys Ile Val Lys Phe Phe Val Glu Asn Ile Lys Asn Asn Ser Ile Lys 
        355                 360                 365             


Glu Lys Ile Glu Lys Ile Leu Ala Glu Phe Lys Ile Asp Glu Leu Ile 
    370                 375                 380                 


Lys Lys Leu Glu Lys Glu Leu Lys Lys Gly Asn Cys Asp Thr Glu Ile 
385                 390                 395                 400 


Phe Gly Ile Phe Lys Lys His Tyr Lys Val Asn Phe Asp Ser Lys Lys 
                405                 410                 415     


Phe Ser Lys Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr 
            420                 425                 430         


Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Val Asn Glu Gln Lys 
        435                 440                 445             


Val Arg Leu Lys Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn 
    450                 455                 460                 


Glu Ser Ile Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr 
465                 470                 475                 480 


Leu Glu His Ile Met Tyr Leu Gly Lys Leu Arg His Asn Asp Ile Asp 
                485                 490                 495     


Met Thr Thr Val Asn Thr Asp Asp Phe Ser Arg Leu His Ala Lys Glu 
            500                 505                 510         


Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu 
        515                 520                 525             


Leu Asn Lys Ile Phe Ser Arg Glu Asn Ile Asn Asn Asp Glu Asn Ile 
    530                 535                 540                 


Asp Phe Phe Gly Gly Asp Arg Glu Lys Asn Tyr Val Leu Asp Lys Lys 
545                 550                 555                 560 


Ile Leu Asn Ser Lys Ile Lys Ile Ile Arg Asp Leu Asp Phe Ile Asp 
                565                 570                 575     


Asn Lys Asn Asn Ile Thr Asn Asn Phe Ile Arg Lys Phe Thr Lys Ile 
            580                 585                 590         


Gly Thr Asn Glu Arg Asn Arg Ile Leu His Ala Ile Ser Lys Glu Arg 
        595                 600                 605             


Asp Leu Gln Gly Thr Gln Asp Asp Tyr Asn Lys Val Ile Asn Ile Ile 
    610                 615                 620                 


Gln Asn Leu Lys Ile Ser Asp Glu Glu Val Ser Lys Ala Leu Asn Leu 
625                 630                 635                 640 


Asp Val Val Phe Lys Asp Lys Lys Asn Ile Ile Thr Lys Ile Asn Asp 
                645                 650                 655     


Ile Lys Ile Ser Glu Glu Asn Asn Asn Asp Ile Lys Tyr Leu Pro Ser 
            660                 665                 670         


Phe Ser Lys Val Leu Pro Glu Ile Leu Asn Leu Tyr Arg Asn Asn Pro 
        675                 680                 685             


Lys Asn Glu Pro Phe Asp Thr Ile Glu Thr Glu Lys Ile Val Leu Asn 
    690                 695                 700                 


Ala Leu Ile Tyr Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu 
705                 710                 715                 720 


Asp Asp Leu Glu Glu Asn Glu Ser Lys Asn Ile Phe Leu Gln Glu Leu 
                725                 730                 735     


Lys Lys Thr Leu Gly Asn Ile Asp Glu Ile Asp Glu Asn Ile Ile Glu 
            740                 745                 750         


Asn Tyr Tyr Lys Asn Ala Gln Ile Ser Ala Ser Lys Gly Asn Asn Lys 
        755                 760                 765             


Ala Ile Lys Lys Tyr Gln Lys Lys Val Ile Glu Cys Tyr Ile Gly Tyr 
    770                 775                 780                 


Leu Arg Lys Asn Tyr Glu Glu Leu Phe Asp Phe Ser Asp Phe Lys Met 
785                 790                 795                 800 


Asn Ile Gln Glu Ile Lys Lys Gln Ile Lys Asp Ile Asn Asp Asn Lys 
                805                 810                 815     


Thr Tyr Glu Arg Ile Thr Val Lys Thr Ser Asp Lys Thr Ile Val Ile 
            820                 825                 830         


Asn Asp Asp Phe Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Ser 
        835                 840                 845             


Asn Ala Val Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val 
    850                 855                 860                 


Trp Leu Asn Thr Ser Glu Tyr Gln Asn Ile Ile Asp Ile Leu Asp Glu 
865                 870                 875                 880 


Ile Met Gln Leu Asn Thr Leu Arg Asn Glu Cys Ile Thr Glu Asn Trp 
                885                 890                 895     


Asn Leu Asn Leu Glu Glu Phe Ile Gln Lys Met Lys Glu Ile Glu Lys 
            900                 905                 910         


Asp Phe Asp Asp Phe Lys Ile Gln Thr Lys Lys Glu Ile Phe Asn Asn 
        915                 920                 925             


Tyr Tyr Glu Asp Ile Lys Asn Asn Ile Leu Thr Glu Phe Lys Asp Asp 
    930                 935                 940                 


Ile Asn Gly Cys Asp Val Leu Glu Lys Lys Leu Glu Lys Ile Val Ile 
945                 950                 955                 960 


Phe Asp Asp Glu Thr Lys Phe Glu Ile Asp Lys Lys Ser Asn Ile Leu 
                965                 970                 975     


Gln Asp Glu Gln Arg Lys Leu Ser Asn Ile Asn Lys Lys Asp Leu Lys 
            980                 985                 990         


Lys Lys Val Asp Gln Tyr Ile Lys  Asp Lys Asp Gln Glu  Ile Lys Ser 
        995                 1000                 1005             


Lys Ile  Leu Cys Arg Ile Ile  Phe Asn Ser Asp Phe  Leu Lys Lys 
    1010                 1015                 1020             


Tyr Lys  Lys Glu Ile Asp Asn  Leu Ile Glu Asp Met  Glu Ser Glu 
    1025                 1030                 1035             


Asn Glu  Asn Lys Phe Gln Glu  Ile Tyr Tyr Pro Lys  Glu Arg Lys 
    1040                 1045                 1050             


Asn Glu  Leu Tyr Ile Tyr Lys  Lys Asn Leu Phe Leu  Asn Ile Gly 
    1055                 1060                 1065             


Asn Pro  Asn Phe Asp Lys Ile  Tyr Gly Leu Ile Ser  Asn Asp Ile 
    1070                 1075                 1080             


Lys Met  Ala Asp Ala Lys Phe  Leu Phe Asn Ile Asp  Gly Lys Asn 
    1085                 1090                 1095             


Ile Arg  Lys Asn Lys Ile Ser  Glu Ile Asp Ala Ile  Leu Lys Asn 
    1100                 1105                 1110             


Leu Asn  Asp Lys Leu Asn Gly  Tyr Ser Lys Glu Tyr  Lys Glu Lys 
    1115                 1120                 1125             


Tyr Ile  Lys Lys Leu Lys Glu  Asn Asp Asp Phe Phe  Ala Lys Asn 
    1130                 1135                 1140             


Ile Gln  Asn Lys Asn Tyr Lys  Ser Phe Glu Lys Asp  Tyr Asn Arg 
    1145                 1150                 1155             


Val Ser  Glu Tyr Lys Lys Ile  Arg Asp Leu Val Glu  Phe Asn Tyr 
    1160                 1165                 1170             


Leu Asn  Lys Ile Glu Ser Tyr  Leu Ile Asp Ile Asn  Trp Lys Leu 
    1175                 1180                 1185             


Ala Ile  Gln Met Ala Arg Phe  Glu Arg Asp Met His  Tyr Ile Val 
    1190                 1195                 1200             


Asn Gly  Leu Arg Glu Leu Gly  Ile Ile Lys Leu Ser  Gly Tyr Asn 
    1205                 1210                 1215             


Thr Gly  Ile Ser Arg Ala Tyr  Pro Lys Arg Asn Gly  Ser Asp Gly 
    1220                 1225                 1230             


Phe Tyr  Thr Thr Thr Ala Tyr  Tyr Lys Phe Phe Asp  Glu Glu Ser 
    1235                 1240                 1245             


Tyr Lys  Lys Phe Glu Lys Ile  Cys Tyr Gly Phe Gly  Ile Asp Leu 
    1250                 1255                 1260             


Ser Glu  Asn Ser Glu Ile Asn  Lys Pro Glu Asn Glu  Ser Ile Arg 
    1265                 1270                 1275             


Asn Tyr  Ile Ser His Phe Tyr  Ile Val Arg Asn Pro  Phe Ala Asp 
    1280                 1285                 1290             


Tyr Ser  Ile Ala Glu Gln Ile  Asp Arg Val Ser Asn  Leu Leu Ser 
    1295                 1300                 1305             


Tyr Ser  Thr Arg Tyr Asn Asn  Ser Thr Tyr Ala Ser  Val Phe Glu 
    1310                 1315                 1320             


Val Phe  Lys Lys Asp Val Asn  Leu Asp Tyr Asp Glu  Leu Lys Lys 
    1325                 1330                 1335             


Lys Phe  Lys Leu Ile Gly Asn  Asn Asp Ile Leu Glu  Arg Leu Met 
    1340                 1345                 1350             


Lys Pro  Lys Lys Val Ser Val  Leu Glu Leu Glu Ser  Tyr Asn Ser 
    1355                 1360                 1365             


Asp Tyr  Ile Lys Asn Leu Ile  Ile Glu Leu Leu Thr  Lys Ile Glu 
    1370                 1375                 1380             


Asn Thr  Asn Asp Thr Leu 
    1385                 


<210>  397
<211>  1050
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  397

Met Arg Ser Asn Tyr His Gly Gly Arg Asn Ala Arg Gln Trp Arg Lys 
1               5                   10                  15      


Gln Ile Ser Gly Leu Ala Arg Arg Thr Lys Glu Thr Val Phe Thr Tyr 
            20                  25                  30          


Lys Phe Pro Leu Glu Thr Asp Ala Ala Glu Ile Asp Phe Asp Lys Ala 
        35                  40                  45              


Val Gln Thr Tyr Gly Ile Ala Glu Gly Val Gly His Gly Ser Leu Ile 
    50                  55                  60                  


Gly Leu Val Cys Ala Phe His Leu Ser Gly Phe Arg Leu Phe Ser Lys 
65                  70                  75                  80  


Ala Gly Glu Ala Met Ala Phe Arg Asn Arg Ser Arg Tyr Pro Thr Asp 
                85                  90                  95      


Ala Phe Ala Glu Lys Leu Ser Ala Ile Met Gly Ile Gln Leu Pro Thr 
            100                 105                 110         


Leu Ser Pro Glu Gly Leu Asp Leu Ile Phe Gln Ser Pro Pro Arg Ser 
        115                 120                 125             


Arg Asp Gly Ile Ala Pro Val Trp Ser Glu Asn Glu Val Arg Asn Arg 
    130                 135                 140                 


Leu Tyr Thr Asn Trp Thr Gly Arg Gly Pro Ala Asn Lys Pro Asp Glu 
145                 150                 155                 160 


His Leu Leu Glu Ile Ala Gly Glu Ile Ala Lys Gln Val Phe Pro Lys 
                165                 170                 175     


Phe Gly Gly Trp Asp Asp Leu Ala Ser Asp Pro Asp Lys Ala Leu Ala 
            180                 185                 190         


Ala Ala Asp Lys Tyr Phe Gln Ser Gln Gly Asp Phe Pro Ser Ile Ala 
        195                 200                 205             


Ser Leu Pro Ala Ala Ile Met Leu Ser Pro Ala Asn Ser Thr Val Asp 
    210                 215                 220                 


Phe Glu Gly Asp Tyr Ile Ala Ile Asp Pro Ala Ala Glu Thr Leu Leu 
225                 230                 235                 240 


His Gln Ala Val Ser Arg Cys Ala Ala Arg Leu Gly Arg Glu Arg Pro 
                245                 250                 255     


Asp Leu Asp Gln Asn Lys Gly Pro Phe Val Ser Ser Leu Gln Asp Ala 
            260                 265                 270         


Leu Val Ser Ser Gln Asn Asn Gly Leu Ser Trp Leu Phe Gly Val Gly 
        275                 280                 285             


Phe Gln His Trp Lys Glu Lys Ser Pro Lys Glu Leu Ile Asp Glu Tyr 
    290                 295                 300                 


Lys Val Pro Ala Asp Gln His Gly Ala Val Thr Gln Val Lys Ser Phe 
305                 310                 315                 320 


Val Asp Ala Ile Pro Leu Asn Pro Leu Phe Asp Thr Thr His Tyr Gly 
                325                 330                 335     


Glu Phe Arg Ala Ser Val Ala Gly Lys Val Arg Ser Trp Val Ala Asn 
            340                 345                 350         


Tyr Trp Lys Arg Leu Leu Asp Leu Lys Ser Leu Leu Ala Thr Thr Glu 
        355                 360                 365             


Phe Thr Leu Pro Glu Ser Ile Ser Asp Pro Lys Ala Val Ser Leu Phe 
    370                 375                 380                 


Ser Gly Leu Leu Val Asp Pro Gln Gly Leu Lys Lys Val Ala Asp Ser 
385                 390                 395                 400 


Leu Pro Ala Arg Leu Val Ser Ala Glu Glu Ala Ile Asp Arg Leu Met 
                405                 410                 415     


Gly Val Gly Ile Pro Thr Ala Ala Asp Ile Ala Gln Val Glu Arg Val 
            420                 425                 430         


Ala Asp Glu Ile Gly Ala Phe Ile Gly Gln Val Gln Gln Phe Asn Asn 
        435                 440                 445             


Gln Val Lys Gln Lys Leu Glu Asn Leu Gln Asp Ala Asp Asp Glu Glu 
    450                 455                 460                 


Phe Leu Lys Gly Leu Lys Ile Glu Leu Pro Ser Gly Asp Lys Glu Pro 
465                 470                 475                 480 


Pro Ala Ile Asn Arg Ile Ser Gly Gly Ala Pro Asp Ala Ala Ala Glu 
                485                 490                 495     


Ile Ser Glu Leu Glu Glu Lys Leu Gln Arg Leu Leu Asp Ala Arg Ser 
            500                 505                 510         


Glu His Phe Gln Thr Ile Ser Glu Trp Ala Glu Glu Asn Ala Val Thr 
        515                 520                 525             


Leu Asp Pro Ile Ala Ala Met Val Glu Leu Glu Arg Leu Arg Leu Ala 
    530                 535                 540                 


Glu Arg Gly Ala Thr Gly Asp Pro Glu Glu Tyr Ala Leu Arg Leu Leu 
545                 550                 555                 560 


Leu Gln Arg Ile Gly Arg Leu Ala Asn Arg Val Ser Pro Val Ser Ala 
                565                 570                 575     


Gly Ser Ile Arg Glu Leu Leu Lys Pro Val Phe Met Glu Glu Arg Glu 
            580                 585                 590         


Phe Asn Leu Phe Phe His Asn Arg Leu Gly Ser Leu Tyr Arg Ser Pro 
        595                 600                 605             


Tyr Ser Thr Ser Arg His Gln Pro Phe Ser Ile Asp Val Gly Lys Ala 
    610                 615                 620                 


Lys Ala Ile Asp Trp Ile Ala Gly Leu Asp Gln Ile Ser Ser Asp Ile 
625                 630                 635                 640 


Glu Lys Ala Leu Ser Gly Ala Gly Glu Ala Leu Gly Asp Gln Leu Arg 
                645                 650                 655     


Asp Trp Ile Asn Leu Ala Gly Phe Ala Ile Ser Gln Arg Leu Arg Gly 
            660                 665                 670         


Leu Pro Asp Thr Val Pro Asn Ala Leu Ala Gln Val Arg Cys Pro Asp 
        675                 680                 685             


Asp Val Arg Ile Pro Pro Leu Leu Ala Met Leu Leu Glu Glu Asp Asp 
    690                 695                 700                 


Ile Ala Arg Asp Val Cys Leu Lys Ala Phe Asn Leu Tyr Val Ser Ala 
705                 710                 715                 720 


Ile Asn Gly Cys Leu Phe Gly Ala Leu Arg Glu Gly Phe Ile Val Arg 
                725                 730                 735     


Thr Arg Phe Gln Arg Ile Gly Thr Asp Gln Ile His Tyr Val Pro Lys 
            740                 745                 750         


Asp Lys Ala Trp Glu Tyr Pro Asp Arg Leu Asn Thr Ala Lys Gly Pro 
        755                 760                 765             


Ile Asn Ala Ala Val Ser Ser Asp Trp Ile Glu Lys Asp Gly Ala Val 
    770                 775                 780                 


Ile Lys Pro Val Glu Thr Val Arg Asn Leu Ser Ser Thr Gly Phe Ala 
785                 790                 795                 800 


Gly Ala Gly Val Ser Glu Tyr Leu Val Gln Ala Pro His Asp Trp Tyr 
                805                 810                 815     


Thr Pro Leu Asp Leu Arg Asp Val Ala His Leu Val Thr Gly Leu Pro 
            820                 825                 830         


Val Glu Lys Asn Ile Thr Lys Leu Lys Arg Leu Thr Asn Arg Thr Ala 
        835                 840                 845             


Phe Arg Met Val Gly Ala Ser Ser Phe Lys Thr His Leu Asp Ser Val 
    850                 855                 860                 


Leu Leu Ser Asp Lys Ile Lys Leu Gly Asp Phe Thr Ile Ile Ile Asp 
865                 870                 875                 880 


Gln His Tyr Arg Gln Ser Val Thr Tyr Gly Gly Lys Val Lys Ile Ser 
                885                 890                 895     


Tyr Glu Pro Glu Arg Leu Gln Val Glu Ala Ala Val Pro Val Val Asp 
            900                 905                 910         


Thr Arg Asp Arg Thr Val Pro Glu Pro Asp Thr Leu Phe Asp His Ile 
        915                 920                 925             


Val Ala Ile Asp Leu Gly Glu Arg Ser Val Gly Phe Ala Val Phe Asp 
    930                 935                 940                 


Ile Lys Ser Cys Leu Arg Thr Gly Glu Val Lys Pro Ile His Asp Asn 
945                 950                 955                 960 


Asn Gly Asn Pro Val Val Gly Thr Val Ala Val Pro Ser Ile Arg Arg 
                965                 970                 975     


Leu Met Lys Ala Val Arg Ser His Arg Arg Arg Arg Gln Pro Asn Gln 
            980                 985                 990         


Lys Val Asn Gln Thr Tyr Ser Thr  Ala Leu Gln Asn Tyr  Arg Glu Asn 
        995                 1000                 1005             


Val Ile  Gly Asp Val Cys Asn  Arg Ile Asp Thr Leu  Met Glu Arg 
    1010                 1015                 1020             


Tyr Asn  Ala Phe Pro Val Leu  Glu Phe Gln Ile Lys  Asn Phe Gln 
    1025                 1030                 1035             


Ala Gly  Ala Lys Gln Leu Glu  Ile Val Tyr Gly Ser  
    1040                 1045                 1050 


<210>  398
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  398

Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Pro Lys Lys Lys Arg Lys 
1               5                   10                  15      


Val 
    


<210>  399
<211>  1395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  399

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly 
                245                 250                 255     


Ile Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val 
            260                 265                 270         


Ile Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn 
        275                 280                 285             


Glu Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg 
    290                 295                 300                 


Arg His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu 
305                 310                 315                 320 


Leu Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg 
                325                 330                 335     


Val Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala 
            340                 345                 350         


Leu Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val 
        355                 360                 365             


Glu Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg 
    370                 375                 380                 


Asn Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu 
385                 390                 395                 400 


Arg Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys 
                405                 410                 415     


Thr Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys 
            420                 425                 430         


Ala Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu 
        435                 440                 445             


Leu Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro 
    450                 455                 460                 


Phe Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His 
465                 470                 475                 480 


Cys Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn 
                485                 490                 495     


Ala Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr 
            500                 505                 510         


Arg Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile 
        515                 520                 525             


Glu Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala 
    530                 535                 540                 


Lys Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr 
545                 550                 555                 560 


Ser Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile 
                565                 570                 575     


Lys Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu 
            580                 585                 590         


Asp Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile 
        595                 600                 605             


Gln Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile 
    610                 615                 620                 


Glu Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser 
625                 630                 635                 640 


Leu Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp 
                645                 650                 655     


Asn Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val 
            660                 665                 670         


Asp Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe 
        675                 680                 685             


Ile Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val 
    690                 695                 700                 


Ile Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile 
705                 710                 715                 720 


Glu Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn 
                725                 730                 735     


Glu Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile 
            740                 745                 750         


Ile Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile 
        755                 760                 765             


Lys Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala 
    770                 775                 780                 


Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp 
785                 790                 795                 800 


His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys 
                805                 810                 815     


Val Leu Val Lys Gln Glu Glu Ala Ser Lys Lys Gly Asn Arg Thr Pro 
            820                 825                 830         


Phe Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe 
        835                 840                 845             


Lys Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys 
    850                 855                 860                 


Thr Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser 
865                 870                 875                 880 


Val Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala 
                885                 890                 895     


Thr Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn 
            900                 905                 910         


Leu Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu 
        915                 920                 925             


Arg Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His 
    930                 935                 940                 


His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys 
945                 950                 955                 960 


Glu Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met 
                965                 970                 975     


Phe Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln 
            980                 985                 990         


Glu Tyr Lys Glu Ile Phe Ile Thr  Pro His Gln Ile Lys  His Ile Lys 
        995                 1000                 1005             


Asp Phe  Lys Asp Tyr Lys Tyr  Ser His Arg Val Asp  Lys Lys Pro 
    1010                 1015                 1020             


Asn Arg  Glu Leu Ile Asn Asp  Thr Leu Tyr Ser Thr  Arg Lys Asp 
    1025                 1030                 1035             


Asp Lys  Gly Asn Thr Leu Ile  Val Asn Asn Leu Asn  Gly Leu Tyr 
    1040                 1045                 1050             


Asp Lys  Asp Asn Asp Lys Leu  Lys Lys Leu Ile Asn  Lys Ser Pro 
    1055                 1060                 1065             


Glu Lys  Leu Leu Met Tyr His  His Asp Pro Gln Thr  Tyr Gln Lys 
    1070                 1075                 1080             


Leu Lys  Leu Ile Met Glu Gln  Tyr Gly Asp Glu Lys  Asn Pro Leu 
    1085                 1090                 1095             


Tyr Lys  Tyr Tyr Glu Glu Thr  Gly Asn Tyr Leu Thr  Lys Tyr Ser 
    1100                 1105                 1110             


Lys Lys  Asp Asn Gly Pro Val  Ile Lys Lys Ile Lys  Tyr Tyr Gly 
    1115                 1120                 1125             


Asn Lys  Leu Asn Ala His Leu  Asp Ile Thr Asp Asp  Tyr Pro Asn 
    1130                 1135                 1140             


Ser Arg  Asn Lys Val Val Lys  Leu Ser Leu Lys Pro  Tyr Arg Phe 
    1145                 1150                 1155             


Asp Val  Tyr Leu Asp Asn Gly  Val Tyr Lys Phe Val  Thr Val Lys 
    1160                 1165                 1170             


Asn Leu  Asp Val Ile Lys Lys  Glu Asn Tyr Tyr Glu  Val Asn Ser 
    1175                 1180                 1185             


Lys Cys  Tyr Glu Glu Ala Lys  Lys Leu Lys Lys Ile  Ser Asn Gln 
    1190                 1195                 1200             


Ala Glu  Phe Ile Ala Ser Phe  Tyr Asn Asn Asp Leu  Ile Lys Ile 
    1205                 1210                 1215             


Asn Gly  Glu Leu Tyr Arg Val  Ile Gly Val Asn Asn  Asp Leu Leu 
    1220                 1225                 1230             


Asn Arg  Ile Glu Val Asn Met  Ile Asp Ile Thr Tyr  Arg Glu Tyr 
    1235                 1240                 1245             


Leu Glu  Asn Met Asn Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr 
    1250                 1255                 1260             


Ile Ala  Ser Lys Thr Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile 
    1265                 1270                 1275             


Leu Gly  Asn Leu Tyr Glu Val  Lys Ser Lys Lys His  Pro Gln Ile 
    1280                 1285                 1290             


Ile Lys  Lys Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1295                 1300                 1305             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1310                 1315                 1320             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1325                 1330                 1335             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1340                 1345                 1350             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1355                 1360                 1365             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1370                 1375                 1380             


Leu Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1385                 1390                 1395 


<210>  400
<211>  1395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  400

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly 
                245                 250                 255     


Ile Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val 
            260                 265                 270         


Ile Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn 
        275                 280                 285             


Glu Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg 
    290                 295                 300                 


Arg His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu 
305                 310                 315                 320 


Leu Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg 
                325                 330                 335     


Val Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala 
            340                 345                 350         


Leu Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val 
        355                 360                 365             


Glu Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg 
    370                 375                 380                 


Asn Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu 
385                 390                 395                 400 


Arg Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys 
                405                 410                 415     


Thr Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys 
            420                 425                 430         


Ala Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu 
        435                 440                 445             


Leu Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro 
    450                 455                 460                 


Phe Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His 
465                 470                 475                 480 


Cys Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn 
                485                 490                 495     


Ala Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr 
            500                 505                 510         


Arg Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile 
        515                 520                 525             


Glu Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala 
    530                 535                 540                 


Lys Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr 
545                 550                 555                 560 


Ser Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile 
                565                 570                 575     


Lys Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu 
            580                 585                 590         


Asp Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile 
        595                 600                 605             


Gln Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile 
    610                 615                 620                 


Glu Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser 
625                 630                 635                 640 


Leu Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp 
                645                 650                 655     


Asn Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val 
            660                 665                 670         


Asp Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe 
        675                 680                 685             


Ile Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val 
    690                 695                 700                 


Ile Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile 
705                 710                 715                 720 


Glu Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn 
                725                 730                 735     


Glu Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile 
            740                 745                 750         


Ile Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile 
        755                 760                 765             


Lys Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala 
    770                 775                 780                 


Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp 
785                 790                 795                 800 


His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys 
                805                 810                 815     


Val Leu Val Lys Gln Glu Glu Ala Ser Lys Lys Gly Asn Arg Thr Pro 
            820                 825                 830         


Phe Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe 
        835                 840                 845             


Lys Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys 
    850                 855                 860                 


Thr Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser 
865                 870                 875                 880 


Val Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala 
                885                 890                 895     


Thr Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn 
            900                 905                 910         


Leu Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu 
        915                 920                 925             


Arg Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His 
    930                 935                 940                 


His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys 
945                 950                 955                 960 


Glu Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met 
                965                 970                 975     


Phe Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln 
            980                 985                 990         


Glu Tyr Lys Glu Ile Phe Ile Thr  Pro His Gln Ile Lys  His Ile Lys 
        995                 1000                 1005             


Asp Phe  Lys Asp Tyr Lys Tyr  Ser His Arg Val Asp  Lys Lys Pro 
    1010                 1015                 1020             


Asn Arg  Lys Leu Ile Asn Asp  Thr Leu Tyr Ser Thr  Arg Lys Asp 
    1025                 1030                 1035             


Asp Lys  Gly Asn Thr Leu Ile  Val Asn Asn Leu Asn  Gly Leu Tyr 
    1040                 1045                 1050             


Asp Lys  Asp Asn Asp Lys Leu  Lys Lys Leu Ile Asn  Lys Ser Pro 
    1055                 1060                 1065             


Glu Lys  Leu Leu Met Tyr His  His Asp Pro Gln Thr  Tyr Gln Lys 
    1070                 1075                 1080             


Leu Lys  Leu Ile Met Glu Gln  Tyr Gly Asp Glu Lys  Asn Pro Leu 
    1085                 1090                 1095             


Tyr Lys  Tyr Tyr Glu Glu Thr  Gly Asn Tyr Leu Thr  Lys Tyr Ser 
    1100                 1105                 1110             


Lys Lys  Asp Asn Gly Pro Val  Ile Lys Lys Ile Lys  Tyr Tyr Gly 
    1115                 1120                 1125             


Asn Lys  Leu Asn Ala His Leu  Asp Ile Thr Asp Asp  Tyr Pro Asn 
    1130                 1135                 1140             


Ser Arg  Asn Lys Val Val Lys  Leu Ser Leu Lys Pro  Tyr Arg Phe 
    1145                 1150                 1155             


Asp Val  Tyr Leu Asp Asn Gly  Val Tyr Lys Phe Val  Thr Val Lys 
    1160                 1165                 1170             


Asn Leu  Asp Val Ile Lys Lys  Glu Asn Tyr Tyr Glu  Val Asn Ser 
    1175                 1180                 1185             


Lys Cys  Tyr Glu Glu Ala Lys  Lys Leu Lys Lys Ile  Ser Asn Gln 
    1190                 1195                 1200             


Ala Glu  Phe Ile Ala Ser Phe  Tyr Lys Asn Asp Leu  Ile Lys Ile 
    1205                 1210                 1215             


Asn Gly  Glu Leu Tyr Arg Val  Ile Gly Val Asn Asn  Asp Leu Leu 
    1220                 1225                 1230             


Asn Arg  Ile Glu Val Asn Met  Ile Asp Ile Thr Tyr  Arg Glu Tyr 
    1235                 1240                 1245             


Leu Glu  Asn Met Asn Asp Lys  Arg Pro Pro His Ile  Ile Lys Thr 
    1250                 1255                 1260             


Ile Ala  Ser Lys Thr Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile 
    1265                 1270                 1275             


Leu Gly  Asn Leu Tyr Glu Val  Lys Ser Lys Lys His  Pro Gln Ile 
    1280                 1285                 1290             


Ile Lys  Lys Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1295                 1300                 1305             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1310                 1315                 1320             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1325                 1330                 1335             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1340                 1345                 1350             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1355                 1360                 1365             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1370                 1375                 1380             


Leu Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1385                 1390                 1395 


<210>  401
<211>  1810
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  401

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Ala 
    1610                 1615                 1620             


Ser Arg  Gly Val Asn Lys Val  Ile Leu Val Gly Asn  Leu Gly Gln 
    1625                 1630                 1635             


Asp Pro  Glu Val Arg Tyr Met  Pro Asn Gly Gly Ala  Val Ala Asn 
    1640                 1645                 1650             


Ile Thr  Leu Ala Thr Ser Glu  Ser Trp Arg Asp Lys  Ala Thr Gly 
    1655                 1660                 1665             


Glu Met  Lys Glu Gln Thr Glu  Trp His Arg Val Val  Leu Phe Gly 
    1670                 1675                 1680             


Lys Leu  Ala Glu Val Ala Ser  Glu Tyr Leu Arg Lys  Gly Ser Gln 
    1685                 1690                 1695             


Val Tyr  Ile Glu Gly Gln Leu  Arg Thr Arg Lys Trp  Thr Asp Gln 
    1700                 1705                 1710             


Ser Gly  Gln Asp Arg Tyr Thr  Thr Glu Val Val Val  Asn Val Gly 
    1715                 1720                 1725             


Gly Thr  Met Gln Met Leu Gly  Gly Arg Gln Gly Gly  Gly Ala Pro 
    1730                 1735                 1740             


Ala Gly  Gly Asn Ile Gly Gly  Gly Gln Pro Gln Gly  Gly Trp Gly 
    1745                 1750                 1755             


Gln Pro  Gln Gln Pro Gln Gly  Gly Asn Gln Phe Ser  Gly Gly Ala 
    1760                 1765                 1770             


Gln Ser  Arg Pro Gln Gln Ser  Ala Pro Ala Ala Pro  Ser Asn Glu 
    1775                 1780                 1785             


Pro Pro  Met Asp Phe Asp Asp  Asp Ile Pro Phe Ser  Gly Gly Ser 
    1790                 1795                 1800             


Pro Lys  Lys Lys Arg Lys Val  
    1805                 1810 


<210>  402
<211>  1716
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  402

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Thr 
    1610                 1615                 1620             


Asn Leu  Ser Asp Ile Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val 
    1625                 1630                 1635             


Ile Gln  Glu Ser Ile Leu Met  Leu Pro Glu Glu Val  Glu Glu Val 
    1640                 1645                 1650             


Ile Gly  Asn Lys Pro Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr 
    1655                 1660                 1665             


Asp Glu  Ser Thr Asp Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala 
    1670                 1675                 1680             


Pro Glu  Tyr Lys Pro Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly 
    1685                 1690                 1695             


Glu Asn  Lys Ile Lys Met Leu  Ser Gly Gly Ser Pro  Lys Lys Lys 
    1700                 1705                 1710             


Arg Lys  Val 
    1715     


<210>  403
<211>  1722
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  403

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Ser  Glu Thr Pro Gly Thr  Ser Glu Ser 
    1610                 1615                 1620             


Ala Thr  Pro Glu Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1625                 1630                 1635             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1640                 1645                 1650             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1655                 1660                 1665             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1670                 1675                 1680             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1685                 1690                 1695             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1700                 1705                 1710             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1715                 1720         


<210>  404
<211>  1726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  404

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser 
225                 230                 235                 240 


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly 
                245                 250                 255     


Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
            260                 265                 270         


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
        275                 280                 285             


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
    290                 295                 300                 


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
305                 310                 315                 320 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
                325                 330                 335     


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
            340                 345                 350         


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
        355                 360                 365             


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
    370                 375                 380                 


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
385                 390                 395                 400 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
                405                 410                 415     


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
            420                 425                 430         


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
        435                 440                 445             


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
    450                 455                 460                 


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
465                 470                 475                 480 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
                485                 490                 495     


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
            500                 505                 510         


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
        515                 520                 525             


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
    530                 535                 540                 


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
545                 550                 555                 560 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
                565                 570                 575     


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
            580                 585                 590         


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
        595                 600                 605             


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
    610                 615                 620                 


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
625                 630                 635                 640 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
                645                 650                 655     


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
            660                 665                 670         


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
        675                 680                 685             


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
    690                 695                 700                 


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
705                 710                 715                 720 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
                725                 730                 735     


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
            740                 745                 750         


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
        755                 760                 765             


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
    770                 775                 780                 


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
785                 790                 795                 800 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
                805                 810                 815     


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
            820                 825                 830         


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
        835                 840                 845             


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
    850                 855                 860                 


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
865                 870                 875                 880 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
                885                 890                 895     


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
            900                 905                 910         


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
        915                 920                 925             


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
    930                 935                 940                 


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
945                 950                 955                 960 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
                965                 970                 975     


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
            980                 985                 990         


Ile Lys Lys Gly Ile Leu Gln Thr  Val Lys Val Val Asp  Glu Leu Val 
        995                 1000                 1005             


Lys Val  Met Gly Arg His Lys  Pro Glu Asn Ile Val  Ile Glu Met 
    1010                 1015                 1020             


Ala Arg  Glu Asn Gln Thr Thr  Gln Lys Gly Gln Lys  Asn Ser Arg 
    1025                 1030                 1035             


Glu Arg  Met Lys Arg Ile Glu  Glu Gly Ile Lys Glu  Leu Gly Ser 
    1040                 1045                 1050             


Gln Ile  Leu Lys Glu His Pro  Val Glu Asn Thr Gln  Leu Gln Asn 
    1055                 1060                 1065             


Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn Gly Arg  Asp Met Tyr 
    1070                 1075                 1080             


Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu Ser Asp  Tyr Asp Val 
    1085                 1090                 1095             


Asp His  Ile Val Pro Gln Ser  Phe Leu Lys Asp Asp  Ser Ile Asp 
    1100                 1105                 1110             


Asn Lys  Val Leu Thr Arg Ser  Asp Lys Asn Arg Gly  Lys Ser Asp 
    1115                 1120                 1125             


Asn Val  Pro Ser Glu Glu Val  Val Lys Lys Met Lys  Asn Tyr Trp 
    1130                 1135                 1140             


Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr Gln Arg  Lys Phe Asp 
    1145                 1150                 1155             


Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu Ser Glu  Leu Asp Lys 
    1160                 1165                 1170             


Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu Thr Arg  Gln Ile Thr 
    1175                 1180                 1185             


Lys His  Val Ala Gln Ile Leu  Asp Ser Arg Met Asn  Thr Lys Tyr 
    1190                 1195                 1200             


Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val Lys Val  Ile Thr Leu 
    1205                 1210                 1215             


Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
    1220                 1225                 1230             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1235                 1240                 1245             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1250                 1255                 1260             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1265                 1270                 1275             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1280                 1285                 1290             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1295                 1300                 1305             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1310                 1315                 1320             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1325                 1330                 1335             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1340                 1345                 1350             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1355                 1360                 1365             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1370                 1375                 1380             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1385                 1390                 1395             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1400                 1405                 1410             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1415                 1420                 1425             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1430                 1435                 1440             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1445                 1450                 1455             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1460                 1465                 1470             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1475                 1480                 1485             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1490                 1495                 1500             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1505                 1510                 1515             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1520                 1525                 1530             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1535                 1540                 1545             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1550                 1555                 1560             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1565                 1570                 1575             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1580                 1585                 1590             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1595                 1600                 1605             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1610                 1615                 1620             


Gln Leu  Gly Gly Asp Ser Gly  Gly Ser Thr Asn Leu  Ser Asp Ile 
    1625                 1630                 1635             


Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile 
    1640                 1645                 1650             


Leu Met  Leu Pro Glu Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro 
    1655                 1660                 1665             


Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp 
    1670                 1675                 1680             


Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro 
    1685                 1690                 1695             


Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys 
    1700                 1705                 1710             


Met Leu  Ser Gly Gly Ser Pro  Lys Lys Lys Arg Lys  Val 
    1715                 1720                 1725     


<210>  405
<211>  1797
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  405

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1610                 1615                 1620             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1625                 1630                 1635             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1640                 1645                 1650             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1655                 1660                 1665             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1670                 1675                 1680             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1685                 1690                 1695             


Leu Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1700                 1705                 1710             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1715                 1720                 1725             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1730                 1735                 1740             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1745                 1750                 1755             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1760                 1765                 1770             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1775                 1780                 1785             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1790                 1795         


<210>  406
<211>  1825
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  406

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser 
225                 230                 235                 240 


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly 
                245                 250                 255     


Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
            260                 265                 270         


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
        275                 280                 285             


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
    290                 295                 300                 


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
305                 310                 315                 320 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
                325                 330                 335     


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
            340                 345                 350         


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
        355                 360                 365             


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
    370                 375                 380                 


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
385                 390                 395                 400 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
                405                 410                 415     


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
            420                 425                 430         


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
        435                 440                 445             


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
    450                 455                 460                 


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
465                 470                 475                 480 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
                485                 490                 495     


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
            500                 505                 510         


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
        515                 520                 525             


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
    530                 535                 540                 


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
545                 550                 555                 560 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
                565                 570                 575     


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
            580                 585                 590         


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
        595                 600                 605             


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
    610                 615                 620                 


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
625                 630                 635                 640 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
                645                 650                 655     


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
            660                 665                 670         


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
        675                 680                 685             


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
    690                 695                 700                 


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
705                 710                 715                 720 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
                725                 730                 735     


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
            740                 745                 750         


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
        755                 760                 765             


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
    770                 775                 780                 


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
785                 790                 795                 800 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
                805                 810                 815     


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
            820                 825                 830         


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
        835                 840                 845             


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
    850                 855                 860                 


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
865                 870                 875                 880 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
                885                 890                 895     


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
            900                 905                 910         


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
        915                 920                 925             


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
    930                 935                 940                 


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
945                 950                 955                 960 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
                965                 970                 975     


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
            980                 985                 990         


Ile Lys Lys Gly Ile Leu Gln Thr  Val Lys Val Val Asp  Glu Leu Val 
        995                 1000                 1005             


Lys Val  Met Gly Arg His Lys  Pro Glu Asn Ile Val  Ile Glu Met 
    1010                 1015                 1020             


Ala Arg  Glu Asn Gln Thr Thr  Gln Lys Gly Gln Lys  Asn Ser Arg 
    1025                 1030                 1035             


Glu Arg  Met Lys Arg Ile Glu  Glu Gly Ile Lys Glu  Leu Gly Ser 
    1040                 1045                 1050             


Gln Ile  Leu Lys Glu His Pro  Val Glu Asn Thr Gln  Leu Gln Asn 
    1055                 1060                 1065             


Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn Gly Arg  Asp Met Tyr 
    1070                 1075                 1080             


Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu Ser Asp  Tyr Asp Val 
    1085                 1090                 1095             


Asp His  Ile Val Pro Gln Ser  Phe Leu Lys Asp Asp  Ser Ile Asp 
    1100                 1105                 1110             


Asn Lys  Val Leu Thr Arg Ser  Asp Lys Asn Arg Gly  Lys Ser Asp 
    1115                 1120                 1125             


Asn Val  Pro Ser Glu Glu Val  Val Lys Lys Met Lys  Asn Tyr Trp 
    1130                 1135                 1140             


Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr Gln Arg  Lys Phe Asp 
    1145                 1150                 1155             


Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu Ser Glu  Leu Asp Lys 
    1160                 1165                 1170             


Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu Thr Arg  Gln Ile Thr 
    1175                 1180                 1185             


Lys His  Val Ala Gln Ile Leu  Asp Ser Arg Met Asn  Thr Lys Tyr 
    1190                 1195                 1200             


Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val Lys Val  Ile Thr Leu 
    1205                 1210                 1215             


Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
    1220                 1225                 1230             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1235                 1240                 1245             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1250                 1255                 1260             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1265                 1270                 1275             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1280                 1285                 1290             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1295                 1300                 1305             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1310                 1315                 1320             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1325                 1330                 1335             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1340                 1345                 1350             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1355                 1360                 1365             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1370                 1375                 1380             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1385                 1390                 1395             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1400                 1405                 1410             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1415                 1420                 1425             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1430                 1435                 1440             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1445                 1450                 1455             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1460                 1465                 1470             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1475                 1480                 1485             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1490                 1495                 1500             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1505                 1510                 1515             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1520                 1525                 1530             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1535                 1540                 1545             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1550                 1555                 1560             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1565                 1570                 1575             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1580                 1585                 1590             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1595                 1600                 1605             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1610                 1615                 1620             


Gln Leu  Gly Gly Asp Ser Gly  Gly Ser Gly Gly Ser  Gly Gly Ser 
    1625                 1630                 1635             


Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu Thr Gly  Lys Gln Leu 
    1640                 1645                 1650             


Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro Glu Glu  Val Glu Glu 
    1655                 1660                 1665             


Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile Leu Val  His Thr Ala 
    1670                 1675                 1680             


Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met Leu Leu  Thr Ser Asp 
    1685                 1690                 1695             


Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val Ile Gln  Asp Ser Asn 
    1700                 1705                 1710             


Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly Gly Ser  Gly Gly Ser 
    1715                 1720                 1725             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1730                 1735                 1740             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1745                 1750                 1755             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1760                 1765                 1770             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1775                 1780                 1785             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1790                 1795                 1800             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1805                 1810                 1815             


Pro Lys  Lys Lys Arg Lys Val  
    1820                 1825 


<210>  407
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  407

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  408

<400>  408
000

<210>  409
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  409

Ala Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Phe 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  410
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  410

Ser Glu Val Glu Phe Ser Tyr Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Thr Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Ser His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Ser Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  411
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  411

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Gly Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val His Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Asn Asp Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  412
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  412

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Gly Gly Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val His Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Asn Asp Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  413
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  413

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Asp Gly Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Lys Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Asn Gly Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  414
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  414

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Gln Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Asn Ala Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  415
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  415

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Met Gly Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Pro Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Asn Asp Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  416
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  416

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Cys Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val His Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Asn Ala Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  417
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  417

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Asn Leu Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  418
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  418

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Gly Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Asn Ala Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  419
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  419

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly His His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Asn Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  420
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  420

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Ala Gly Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Asn Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Asn Glu Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  421

<400>  421
000

<210>  422
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  422

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Thr Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Thr Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  423
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  423

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Ser Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  424
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  424

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  425

<400>  425
000

<210>  426
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  426

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Leu Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  427
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  427

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Asn Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  428
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  428

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Cys Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  429
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  429

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Arg Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  430
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  430

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Ser Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly His His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  431
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  431

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Asn Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  432

<400>  432
000

<210>  433
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  433

Gly Ser His Met Thr Asn Asp Ile Tyr Phe Met Thr Leu Ala Ile Glu 
1               5                   10                  15      


Glu Ala Lys Lys Ala Ala Gln Leu Gly Glu Val Pro Ile Gly Ala Ile 
            20                  25                  30          


Ile Thr Lys Asp Asp Glu Val Ile Ala Arg Ala His Asn Leu Arg Glu 
        35                  40                  45              


Thr Leu Gln Gln Pro Thr Ala His Ala Glu His Ile Ala Ile Glu Arg 
    50                  55                  60                  


Ala Ala Lys Val Leu Gly Ser Trp Arg Leu Glu Gly Cys Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Thr Ile Val Met Ser 
                85                  90                  95      


Arg Ile Pro Arg Val Val Tyr Gly Ala Asp Asn Pro Lys Gly Gly Cys 
            100                 105                 110         


Ser Gly Ser Leu Met Asn Leu Leu Gln Gln Ser Asn Phe Asn His Arg 
        115                 120                 125             


Ala Ile Val Asp Lys Gly Val Leu Lys Glu Ala Cys Ser Thr Leu Leu 
    130                 135                 140                 


Thr Thr Phe Phe Lys Asn Leu Arg Ala Asn Lys Lys Ser Thr Asn 
145                 150                 155                 


<210>  434
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  434

Gly Ser His Met Thr Asn Asp Ile Tyr Phe Met Thr Leu Ala Ile Glu 
1               5                   10                  15      


Glu Ala Lys Lys Ala Ala Gln Leu Gly Glu Val Pro Ile Gly Ala Ile 
            20                  25                  30          


Ile Thr Lys Asp Asp Glu Val Ile Ala Arg Ala His Asn Leu Arg Glu 
        35                  40                  45              


Thr Leu Gln Gln Pro Thr Ala His Ala Glu His Ile Ala Ile Glu Arg 
    50                  55                  60                  


Ala Ala Lys Val Leu Gly Ser Trp Arg Leu Glu Gly Cys Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Thr Ile Val Met Ser 
                85                  90                  95      


Arg Ile Pro Arg Val Val Tyr Gly Ala Ala Asn Pro Lys Gly Gly Cys 
            100                 105                 110         


Ser Gly Ser Leu Met Asn Leu Leu Gln Gln Ser Asn Phe Asn His Arg 
        115                 120                 125             


Ala Ile Val Asp Lys Gly Val Leu Lys Glu Ala Cys Ser Thr Leu Leu 
    130                 135                 140                 


Thr Thr Phe Phe Lys Asn Leu Arg Ala Asn Lys Lys Ser Thr Asn 
145                 150                 155                 


<210>  435
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  435

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ile Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Gly Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Leu Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Gly His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Gly Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asn  Ser Pro Thr Ala Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Gly  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Val Leu  His Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Val  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Lys Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  436
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  436

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ile Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Gly Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Leu Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Gly His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Gly Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asn  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Val Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asn Arg Lys Gln  Tyr Asn Thr 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile Arg Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  437
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  437

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ile Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Gly Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Leu Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Gly His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Gly Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asn  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Gly  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Ser 
    1205                 1210                 1215             


Val Leu  His Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Ser Glu  Asp Asn Lys Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Ser Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Gly Arg Lys Leu  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  438
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  438

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ser Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  439
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  439

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Thr Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  440
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  440

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  441
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  441

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Asn Ala Leu Leu 
    130                 135                 140                 


Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  442
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  442

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  443
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  443

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Leu Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  444
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  444

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Asp Phe Phe Arg Met Pro Arg Gln Glu Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  445
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  445

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Asp Phe Phe Arg Met His Arg Gln Glu Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  446
<211>  166
<212>  PRT
<213>  E. coli

<400>  446

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  447
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  447

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Cys Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Asn Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  448
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  448

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ser Ile 
        35                  40                  45              


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Cys Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Asn Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  449
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  449

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile 
        35                  40                  45              


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Cys Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Asn Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  450
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  450

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Leu Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile 
        35                  40                  45              


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  451
<211>  160
<212>  PRT
<213>  Staphylococcus aureus

<400>  451

Met Gly Ser His Met Thr Asn Asp Ile Tyr Phe Met Thr Leu Ala Ile 
1               5                   10                  15      


Glu Glu Ala Lys Lys Ala Ala Gln Leu Gly Glu Val Pro Ile Gly Ala 
            20                  25                  30          


Ile Ile Thr Lys Asp Asp Glu Val Ile Ala Arg Ala His Asn Leu Arg 
        35                  40                  45              


Glu Thr Leu Gln Gln Pro Thr Ala His Ala Glu His Ile Ala Ile Glu 
    50                  55                  60                  


Arg Ala Ala Lys Val Leu Gly Ser Trp Arg Leu Glu Gly Cys Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Thr Ile Val Met 
                85                  90                  95      


Ser Arg Ile Pro Arg Val Val Tyr Gly Ala Asp Asp Pro Lys Gly Gly 
            100                 105                 110         


Cys Ser Gly Ser Leu Met Asn Leu Leu Gln Gln Ser Asn Phe Asn His 
        115                 120                 125             


Arg Ala Ile Val Asp Lys Gly Val Leu Lys Glu Ala Cys Ser Thr Leu 
    130                 135                 140                 


Leu Thr Thr Phe Phe Lys Asn Leu Arg Ala Asn Lys Lys Ser Thr Asn 
145                 150                 155                 160 


<210>  452
<211>  161
<212>  PRT
<213>  Bacillus subtilis

<400>  452

Met Thr Gln Asp Glu Leu Tyr Met Lys Glu Ala Ile Lys Glu Ala Lys 
1               5                   10                  15      


Lys Ala Glu Glu Lys Gly Glu Val Pro Ile Gly Ala Val Leu Val Ile 
            20                  25                  30          


Asn Gly Glu Ile Ile Ala Arg Ala His Asn Leu Arg Glu Thr Glu Gln 
        35                  40                  45              


Arg Ser Ile Ala His Ala Glu Met Leu Val Ile Asp Glu Ala Cys Lys 
    50                  55                  60                  


Ala Leu Gly Thr Trp Arg Leu Glu Gly Ala Thr Leu Tyr Val Thr Leu 
65                  70                  75                  80  


Glu Pro Cys Pro Met Cys Ala Gly Ala Val Val Leu Ser Arg Val Glu 
                85                  90                  95      


Lys Val Val Phe Gly Ala Phe Asp Pro Lys Gly Gly Cys Ser Gly Thr 
            100                 105                 110         


Leu Met Asn Leu Leu Gln Glu Glu Arg Phe Asn His Gln Ala Glu Val 
        115                 120                 125             


Val Ser Gly Val Leu Glu Glu Glu Cys Gly Gly Met Leu Ser Ala Phe 
    130                 135                 140                 


Phe Arg Glu Leu Arg Lys Lys Lys Lys Ala Ala Arg Lys Asn Leu Ser 
145                 150                 155                 160 


Glu 
    


<210>  453
<211>  183
<212>  PRT
<213>  Salmonella typhimurium

<400>  453

Met Pro Pro Ala Phe Ile Thr Gly Val Thr Ser Leu Ser Asp Val Glu 
1               5                   10                  15      


Leu Asp His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg 
            20                  25                  30          


Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val His Asn 
        35                  40                  45              


His Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile Gly Arg His Asp 
    50                  55                  60                  


Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val 
65                  70                  75                  80  


Leu Gln Asn Tyr Arg Leu Leu Asp Thr Thr Leu Tyr Val Thr Leu Glu 
                85                  90                  95      


Pro Cys Val Met Cys Ala Gly Ala Met Val His Ser Arg Ile Gly Arg 
            100                 105                 110         


Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu 
        115                 120                 125             


Ile Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Ile 
    130                 135                 140                 


Glu Gly Val Leu Arg Asp Glu Cys Ala Thr Leu Leu Ser Asp Phe Phe 
145                 150                 155                 160 


Arg Met Arg Arg Gln Glu Ile Lys Ala Leu Lys Lys Ala Asp Arg Ala 
                165                 170                 175     


Glu Gly Ala Gly Pro Ala Val 
            180             


<210>  454
<211>  164
<212>  PRT
<213>  S. putrefaciens

<400>  454

Met Asp Glu Tyr Trp Met Gln Val Ala Met Gln Met Ala Glu Lys Ala 
1               5                   10                  15      


Glu Ala Ala Gly Glu Val Pro Val Gly Ala Val Leu Val Lys Asp Gly 
            20                  25                  30          


Gln Gln Ile Ala Thr Gly Tyr Asn Leu Ser Ile Ser Gln His Asp Pro 
        35                  40                  45              


Thr Ala His Ala Glu Ile Leu Cys Leu Arg Ser Ala Gly Lys Lys Leu 
    50                  55                  60                  


Glu Asn Tyr Arg Leu Leu Asp Ala Thr Leu Tyr Ile Thr Leu Glu Pro 
65                  70                  75                  80  


Cys Ala Met Cys Ala Gly Ala Met Val His Ser Arg Ile Ala Arg Val 
                85                  90                  95      


Val Tyr Gly Ala Arg Asp Glu Lys Thr Gly Ala Ala Gly Thr Val Val 
            100                 105                 110         


Asn Leu Leu Gln His Pro Ala Phe Asn His Gln Val Glu Val Thr Ser 
        115                 120                 125             


Gly Val Leu Ala Glu Ala Cys Ser Ala Gln Leu Ser Arg Phe Phe Lys 
    130                 135                 140                 


Arg Arg Arg Asp Glu Lys Lys Ala Leu Lys Leu Ala Gln Arg Ala Gln 
145                 150                 155                 160 


Gln Gly Ile Glu 
                


<210>  455
<211>  173
<212>  PRT
<213>  H. influenzae

<400>  455

Met Asp Ala Ala Lys Val Arg Ser Glu Phe Asp Glu Lys Met Met Arg 
1               5                   10                  15      


Tyr Ala Leu Glu Leu Ala Asp Lys Ala Glu Ala Leu Gly Glu Ile Pro 
            20                  25                  30          


Val Gly Ala Val Leu Val Asp Asp Ala Arg Asn Ile Ile Gly Glu Gly 
        35                  40                  45              


Trp Asn Leu Ser Ile Val Gln Ser Asp Pro Thr Ala His Ala Glu Ile 
    50                  55                  60                  


Ile Ala Leu Arg Asn Gly Ala Lys Asn Ile Gln Asn Tyr Arg Leu Leu 
65                  70                  75                  80  


Asn Ser Thr Leu Tyr Val Thr Leu Glu Pro Cys Thr Met Cys Ala Gly 
                85                  90                  95      


Ala Ile Leu His Ser Arg Ile Lys Arg Leu Val Phe Gly Ala Ser Asp 
            100                 105                 110         


Tyr Lys Thr Gly Ala Ile Gly Ser Arg Phe His Phe Phe Asp Asp Tyr 
        115                 120                 125             


Lys Met Asn His Thr Leu Glu Ile Thr Ser Gly Val Leu Ala Glu Glu 
    130                 135                 140                 


Cys Ser Gln Lys Leu Ser Thr Phe Phe Gln Lys Arg Arg Glu Glu Lys 
145                 150                 155                 160 


Lys Ile Glu Lys Ala Leu Leu Lys Ser Leu Ser Asp Lys 
                165                 170             


<210>  456
<211>  161
<212>  PRT
<213>  Caulobacter crescentus

<400>  456

Met Arg Thr Asp Glu Ser Glu Asp Gln Asp His Arg Met Met Arg Leu 
1               5                   10                  15      


Ala Leu Asp Ala Ala Arg Ala Ala Ala Glu Ala Gly Glu Thr Pro Val 
            20                  25                  30          


Gly Ala Val Ile Leu Asp Pro Ser Thr Gly Glu Val Ile Ala Thr Ala 
        35                  40                  45              


Gly Asn Gly Pro Ile Ala Ala His Asp Pro Thr Ala His Ala Glu Ile 
    50                  55                  60                  


Ala Ala Met Arg Ala Ala Ala Ala Lys Leu Gly Asn Tyr Arg Leu Thr 
65                  70                  75                  80  


Asp Leu Thr Leu Val Val Thr Leu Glu Pro Cys Ala Met Cys Ala Gly 
                85                  90                  95      


Ala Ile Ser His Ala Arg Ile Gly Arg Val Val Phe Gly Ala Asp Asp 
            100                 105                 110         


Pro Lys Gly Gly Ala Val Val His Gly Pro Lys Phe Phe Ala Gln Pro 
        115                 120                 125             


Thr Cys His Trp Arg Pro Glu Val Thr Gly Gly Val Leu Ala Asp Glu 
    130                 135                 140                 


Ser Ala Asp Leu Leu Arg Gly Phe Phe Arg Ala Arg Arg Lys Ala Lys 
145                 150                 155                 160 


Ile 
    


<210>  457
<211>  179
<212>  PRT
<213>  Geobacter sulfurreducens

<400>  457

Met Ser Ser Leu Lys Lys Thr Pro Ile Arg Asp Asp Ala Tyr Trp Met 
1               5                   10                  15      


Gly Lys Ala Ile Arg Glu Ala Ala Lys Ala Ala Ala Arg Asp Glu Val 
            20                  25                  30          


Pro Ile Gly Ala Val Ile Val Arg Asp Gly Ala Val Ile Gly Arg Gly 
        35                  40                  45              


His Asn Leu Arg Glu Gly Ser Asn Asp Pro Ser Ala His Ala Glu Met 
    50                  55                  60                  


Ile Ala Ile Arg Gln Ala Ala Arg Arg Ser Ala Asn Trp Arg Leu Thr 
65                  70                  75                  80  


Gly Ala Thr Leu Tyr Val Thr Leu Glu Pro Cys Leu Met Cys Met Gly 
                85                  90                  95      


Ala Ile Ile Leu Ala Arg Leu Glu Arg Val Val Phe Gly Cys Tyr Asp 
            100                 105                 110         


Pro Lys Gly Gly Ala Ala Gly Ser Leu Tyr Asp Leu Ser Ala Asp Pro 
        115                 120                 125             


Arg Leu Asn His Gln Val Arg Leu Ser Pro Gly Val Cys Gln Glu Glu 
    130                 135                 140                 


Cys Gly Thr Met Leu Ser Asp Phe Phe Arg Asp Leu Arg Arg Arg Lys 
145                 150                 155                 160 


Lys Ala Lys Ala Thr Pro Ala Leu Phe Ile Asp Glu Arg Lys Val Pro 
                165                 170                 175     


Pro Glu Pro 
            


<210>  458
<211>  1774
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  458

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Tyr Phe Phe Arg Met Arg Arg Gln Val Phe Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
                165                 170                 175     


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly 
            180                 185                 190         


Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr Trp 
        195                 200                 205             


Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu 
    210                 215                 220                 


Val Pro Val Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu 
225                 230                 235                 240 


Gly Trp Asn Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu 
                245                 250                 255     


Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu 
            260                 265                 270         


Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala 
        275                 280                 285             


Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg 
    290                 295                 300                 


Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His Tyr 
305                 310                 315                 320 


Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp 
                325                 330                 335     


Glu Cys Ala Ala Leu Leu Ser Tyr Phe Phe Arg Met Arg Arg Gln Val 
            340                 345                 350         


Phe Lys Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser 
        355                 360                 365             


Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 
    370                 375                 380                 


Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr 
385                 390                 395                 400 


Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile 
                405                 410                 415     


Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn 
            420                 425                 430         


Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe 
        435                 440                 445             


Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg 
    450                 455                 460                 


Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile 
465                 470                 475                 480 


Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu 
                485                 490                 495     


Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro 
            500                 505                 510         


Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro 
        515                 520                 525             


Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala 
    530                 535                 540                 


Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg 
545                 550                 555                 560 


Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val 
                565                 570                 575     


Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu 
            580                 585                 590         


Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser 
        595                 600                 605             


Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu 
    610                 615                 620                 


Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser 
625                 630                 635                 640 


Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp 
                645                 650                 655     


Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn 
            660                 665                 670         


Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala 
        675                 680                 685             


Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn 
    690                 695                 700                 


Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr 
705                 710                 715                 720 


Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln 
                725                 730                 735     


Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn 
            740                 745                 750         


Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr 
        755                 760                 765             


Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu 
    770                 775                 780                 


Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe 
785                 790                 795                 800 


Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala 
                805                 810                 815     


Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg 
            820                 825                 830         


Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly 
        835                 840                 845             


Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser 
    850                 855                 860                 


Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly 
865                 870                 875                 880 


Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn 
                885                 890                 895     


Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr 
            900                 905                 910         


Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly 
        915                 920                 925             


Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val 
    930                 935                 940                 


Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys 
945                 950                 955                 960 


Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser 
                965                 970                 975     


Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu 
            980                 985                 990         


Leu Lys Ile Ile Lys Asp Lys Asp  Phe Leu Asp Asn Glu  Glu Asn Glu 
        995                 1000                 1005             


Asp Ile  Leu Glu Asp Ile Val  Leu Thr Leu Thr Leu  Phe Glu Asp 
    1010                 1015                 1020             


Arg Glu  Met Ile Glu Glu Arg  Leu Lys Thr Tyr Ala  His Leu Phe 
    1025                 1030                 1035             


Asp Asp  Lys Val Met Lys Gln  Leu Lys Arg Arg Arg  Tyr Thr Gly 
    1040                 1045                 1050             


Trp Gly  Arg Leu Ser Arg Lys  Leu Ile Asn Gly Ile  Arg Asp Lys 
    1055                 1060                 1065             


Gln Ser  Gly Lys Thr Ile Leu  Asp Phe Leu Lys Ser  Asp Gly Phe 
    1070                 1075                 1080             


Ala Asn  Arg Asn Phe Met Gln  Leu Ile His Asp Asp  Ser Leu Thr 
    1085                 1090                 1095             


Phe Lys  Glu Asp Ile Gln Lys  Ala Gln Val Ser Gly  Gln Gly Asp 
    1100                 1105                 1110             


Ser Leu  His Glu His Ile Ala  Asn Leu Ala Gly Ser  Pro Ala Ile 
    1115                 1120                 1125             


Lys Lys  Gly Ile Leu Gln Thr  Val Lys Val Val Asp  Glu Leu Val 
    1130                 1135                 1140             


Lys Val  Met Gly Arg His Lys  Pro Glu Asn Ile Val  Ile Glu Met 
    1145                 1150                 1155             


Ala Arg  Glu Asn Gln Thr Thr  Gln Lys Gly Gln Lys  Asn Ser Arg 
    1160                 1165                 1170             


Glu Arg  Met Lys Arg Ile Glu  Glu Gly Ile Lys Glu  Leu Gly Ser 
    1175                 1180                 1185             


Gln Ile  Leu Lys Glu His Pro  Val Glu Asn Thr Gln  Leu Gln Asn 
    1190                 1195                 1200             


Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn Gly Arg  Asp Met Tyr 
    1205                 1210                 1215             


Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu Ser Asp  Tyr Asp Val 
    1220                 1225                 1230             


Asp His  Ile Val Pro Gln Ser  Phe Leu Lys Asp Asp  Ser Ile Asp 
    1235                 1240                 1245             


Asn Lys  Val Leu Thr Arg Ser  Asp Lys Asn Arg Gly  Lys Ser Asp 
    1250                 1255                 1260             


Asn Val  Pro Ser Glu Glu Val  Val Lys Lys Met Lys  Asn Tyr Trp 
    1265                 1270                 1275             


Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr Gln Arg  Lys Phe Asp 
    1280                 1285                 1290             


Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu Ser Glu  Leu Asp Lys 
    1295                 1300                 1305             


Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu Thr Arg  Gln Ile Thr 
    1310                 1315                 1320             


Lys His  Val Ala Gln Ile Leu  Asp Ser Arg Met Asn  Thr Lys Tyr 
    1325                 1330                 1335             


Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val Lys Val  Ile Thr Leu 
    1340                 1345                 1350             


Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
    1355                 1360                 1365             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1370                 1375                 1380             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1385                 1390                 1395             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1400                 1405                 1410             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1415                 1420                 1425             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1430                 1435                 1440             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1445                 1450                 1455             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1460                 1465                 1470             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1475                 1480                 1485             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1490                 1495                 1500             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1505                 1510                 1515             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1520                 1525                 1530             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1535                 1540                 1545             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1550                 1555                 1560             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1565                 1570                 1575             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1580                 1585                 1590             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1595                 1600                 1605             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1610                 1615                 1620             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1625                 1630                 1635             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1640                 1645                 1650             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1655                 1660                 1665             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1670                 1675                 1680             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1685                 1690                 1695             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1700                 1705                 1710             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1715                 1720                 1725             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1730                 1735                 1740             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1745                 1750                 1755             


Gln Leu  Gly Gly Asp Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1760                 1765                 1770             


Val 
    


<210>  459
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  459

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Leu Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  460
<211>  1767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  460

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
385                 390                 395                 400 


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
                405                 410                 415     


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
            420                 425                 430         


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
        435                 440                 445             


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
    450                 455                 460                 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
465                 470                 475                 480 


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
                485                 490                 495     


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
            500                 505                 510         


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
        515                 520                 525             


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
    530                 535                 540                 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
545                 550                 555                 560 


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
                565                 570                 575     


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
            580                 585                 590         


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
        595                 600                 605             


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
    610                 615                 620                 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
625                 630                 635                 640 


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
                645                 650                 655     


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
            660                 665                 670         


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
        675                 680                 685             


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
    690                 695                 700                 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
705                 710                 715                 720 


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
                725                 730                 735     


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
            740                 745                 750         


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
        755                 760                 765             


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
    770                 775                 780                 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
785                 790                 795                 800 


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
                805                 810                 815     


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
            820                 825                 830         


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
        835                 840                 845             


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
    850                 855                 860                 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
865                 870                 875                 880 


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
                885                 890                 895     


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
            900                 905                 910         


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
        915                 920                 925             


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
    930                 935                 940                 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
945                 950                 955                 960 


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
                965                 970                 975     


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
            980                 985                 990         


Asp Phe Leu Asp Asn Glu Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val 
        995                 1000                 1005             


Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg 
    1010                 1015                 1020             


Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp Lys Val  Met Lys Gln 
    1025                 1030                 1035             


Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys 
    1040                 1045                 1050             


Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln 
    1070                 1075                 1080             


Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys 
    1085                 1090                 1095             


Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu His Glu  His Ile Ala 
    1100                 1105                 1110             


Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr 
    1115                 1120                 1125             


Val Lys  Val Val Asp Glu Leu  Val Lys Val Met Gly  Arg His Lys 
    1130                 1135                 1140             


Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr 
    1145                 1150                 1155             


Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
    1160                 1165                 1170             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1175                 1180                 1185             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1190                 1195                 1200             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1205                 1210                 1215             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His Ile Val  Pro Gln Ser 
    1220                 1225                 1230             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1235                 1240                 1245             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1250                 1255                 1260             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1265                 1270                 1275             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    1280                 1285                 1290             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    1295                 1300                 1305             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1310                 1315                 1320             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1325                 1330                 1335             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1340                 1345                 1350             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1355                 1360                 1365             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1370                 1375                 1380             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1385                 1390                 1395             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1400                 1405                 1410             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1415                 1420                 1425             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1430                 1435                 1440             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1445                 1450                 1455             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1460                 1465                 1470             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1475                 1480                 1485             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1490                 1495                 1500             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1505                 1510                 1515             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1520                 1525                 1530             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1535                 1540                 1545             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1550                 1555                 1560             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1565                 1570                 1575             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1580                 1585                 1590             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1595                 1600                 1605             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1610                 1615                 1620             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1625                 1630                 1635             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1640                 1645                 1650             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1655                 1660                 1665             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1670                 1675                 1680             


Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile 
    1685                 1690                 1695             


His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys 
    1700                 1705                 1710             


Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys 
    1715                 1720                 1725             


Glu Val  Leu Asp Ala Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1730                 1735                 1740             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly 
    1745                 1750                 1755             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1760                 1765         


<210>  461
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  461

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Ser Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Lys Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  462
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  462

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Pro Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  463
<211>  1767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  463

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Pro Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
385                 390                 395                 400 


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
                405                 410                 415     


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
            420                 425                 430         


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
        435                 440                 445             


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
    450                 455                 460                 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
465                 470                 475                 480 


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
                485                 490                 495     


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
            500                 505                 510         


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
        515                 520                 525             


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
    530                 535                 540                 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
545                 550                 555                 560 


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
                565                 570                 575     


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
            580                 585                 590         


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
        595                 600                 605             


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
    610                 615                 620                 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
625                 630                 635                 640 


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
                645                 650                 655     


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
            660                 665                 670         


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
        675                 680                 685             


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
    690                 695                 700                 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
705                 710                 715                 720 


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
                725                 730                 735     


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
            740                 745                 750         


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
        755                 760                 765             


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
    770                 775                 780                 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
785                 790                 795                 800 


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
                805                 810                 815     


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
            820                 825                 830         


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
        835                 840                 845             


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
    850                 855                 860                 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
865                 870                 875                 880 


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
                885                 890                 895     


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
            900                 905                 910         


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
        915                 920                 925             


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
    930                 935                 940                 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
945                 950                 955                 960 


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
                965                 970                 975     


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
            980                 985                 990         


Asp Phe Leu Asp Asn Glu Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val 
        995                 1000                 1005             


Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg 
    1010                 1015                 1020             


Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp Lys Val  Met Lys Gln 
    1025                 1030                 1035             


Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys 
    1040                 1045                 1050             


Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln 
    1070                 1075                 1080             


Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys 
    1085                 1090                 1095             


Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu His Glu  His Ile Ala 
    1100                 1105                 1110             


Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr 
    1115                 1120                 1125             


Val Lys  Val Val Asp Glu Leu  Val Lys Val Met Gly  Arg His Lys 
    1130                 1135                 1140             


Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr 
    1145                 1150                 1155             


Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
    1160                 1165                 1170             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1175                 1180                 1185             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1190                 1195                 1200             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1205                 1210                 1215             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His Ile Val  Pro Gln Ser 
    1220                 1225                 1230             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1235                 1240                 1245             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1250                 1255                 1260             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1265                 1270                 1275             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    1280                 1285                 1290             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    1295                 1300                 1305             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1310                 1315                 1320             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1325                 1330                 1335             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1340                 1345                 1350             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1355                 1360                 1365             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1370                 1375                 1380             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1385                 1390                 1395             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1400                 1405                 1410             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1415                 1420                 1425             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1430                 1435                 1440             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1445                 1450                 1455             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1460                 1465                 1470             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1475                 1480                 1485             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1490                 1495                 1500             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1505                 1510                 1515             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1520                 1525                 1530             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1535                 1540                 1545             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1550                 1555                 1560             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1565                 1570                 1575             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1580                 1585                 1590             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1595                 1600                 1605             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1610                 1615                 1620             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1625                 1630                 1635             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1640                 1645                 1650             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1655                 1660                 1665             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1670                 1675                 1680             


Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile 
    1685                 1690                 1695             


His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys 
    1700                 1705                 1710             


Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys 
    1715                 1720                 1725             


Glu Val  Leu Asp Ala Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1730                 1735                 1740             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly 
    1745                 1750                 1755             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1760                 1765         


<210>  464
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  464

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ser Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  465
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  465

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ser Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Asn Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  466
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  466

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  467
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  467

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Asn Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  468
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  468

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  469
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  469

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Leu Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Asn Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  470
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  470

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Leu Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Asn Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  471
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  471

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  472
<211>  1767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  472

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
385                 390                 395                 400 


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
                405                 410                 415     


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
            420                 425                 430         


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
        435                 440                 445             


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
    450                 455                 460                 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
465                 470                 475                 480 


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
                485                 490                 495     


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
            500                 505                 510         


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
        515                 520                 525             


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
    530                 535                 540                 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
545                 550                 555                 560 


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
                565                 570                 575     


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
            580                 585                 590         


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
        595                 600                 605             


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
    610                 615                 620                 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
625                 630                 635                 640 


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
                645                 650                 655     


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
            660                 665                 670         


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
        675                 680                 685             


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
    690                 695                 700                 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
705                 710                 715                 720 


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
                725                 730                 735     


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
            740                 745                 750         


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
        755                 760                 765             


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
    770                 775                 780                 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
785                 790                 795                 800 


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
                805                 810                 815     


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
            820                 825                 830         


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
        835                 840                 845             


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
    850                 855                 860                 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
865                 870                 875                 880 


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
                885                 890                 895     


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
            900                 905                 910         


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
        915                 920                 925             


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
    930                 935                 940                 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
945                 950                 955                 960 


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
                965                 970                 975     


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
            980                 985                 990         


Asp Phe Leu Asp Asn Glu Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val 
        995                 1000                 1005             


Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg 
    1010                 1015                 1020             


Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp Lys Val  Met Lys Gln 
    1025                 1030                 1035             


Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys 
    1040                 1045                 1050             


Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln 
    1070                 1075                 1080             


Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys 
    1085                 1090                 1095             


Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu His Glu  His Ile Ala 
    1100                 1105                 1110             


Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr 
    1115                 1120                 1125             


Val Lys  Val Val Asp Glu Leu  Val Lys Val Met Gly  Arg His Lys 
    1130                 1135                 1140             


Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr 
    1145                 1150                 1155             


Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
    1160                 1165                 1170             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1175                 1180                 1185             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1190                 1195                 1200             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1205                 1210                 1215             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His Ile Val  Pro Gln Ser 
    1220                 1225                 1230             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1235                 1240                 1245             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1250                 1255                 1260             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1265                 1270                 1275             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    1280                 1285                 1290             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    1295                 1300                 1305             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1310                 1315                 1320             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1325                 1330                 1335             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1340                 1345                 1350             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1355                 1360                 1365             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1370                 1375                 1380             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1385                 1390                 1395             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1400                 1405                 1410             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1415                 1420                 1425             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1430                 1435                 1440             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1445                 1450                 1455             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1460                 1465                 1470             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1475                 1480                 1485             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1490                 1495                 1500             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1505                 1510                 1515             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1520                 1525                 1530             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1535                 1540                 1545             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1550                 1555                 1560             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1565                 1570                 1575             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1580                 1585                 1590             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1595                 1600                 1605             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1610                 1615                 1620             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1625                 1630                 1635             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1640                 1645                 1650             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1655                 1660                 1665             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1670                 1675                 1680             


Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile 
    1685                 1690                 1695             


His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys 
    1700                 1705                 1710             


Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys 
    1715                 1720                 1725             


Glu Val  Leu Asp Ala Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1730                 1735                 1740             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly 
    1745                 1750                 1755             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1760                 1765         


<210>  473
<211>  1767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  473

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Asn Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
385                 390                 395                 400 


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
                405                 410                 415     


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
            420                 425                 430         


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
        435                 440                 445             


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
    450                 455                 460                 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
465                 470                 475                 480 


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
                485                 490                 495     


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
            500                 505                 510         


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
        515                 520                 525             


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
    530                 535                 540                 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
545                 550                 555                 560 


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
                565                 570                 575     


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
            580                 585                 590         


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
        595                 600                 605             


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
    610                 615                 620                 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
625                 630                 635                 640 


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
                645                 650                 655     


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
            660                 665                 670         


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
        675                 680                 685             


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
    690                 695                 700                 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
705                 710                 715                 720 


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
                725                 730                 735     


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
            740                 745                 750         


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
        755                 760                 765             


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
    770                 775                 780                 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
785                 790                 795                 800 


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
                805                 810                 815     


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
            820                 825                 830         


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
        835                 840                 845             


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
    850                 855                 860                 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
865                 870                 875                 880 


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
                885                 890                 895     


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
            900                 905                 910         


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
        915                 920                 925             


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
    930                 935                 940                 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
945                 950                 955                 960 


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
                965                 970                 975     


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
            980                 985                 990         


Asp Phe Leu Asp Asn Glu Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val 
        995                 1000                 1005             


Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg 
    1010                 1015                 1020             


Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp Lys Val  Met Lys Gln 
    1025                 1030                 1035             


Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys 
    1040                 1045                 1050             


Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln 
    1070                 1075                 1080             


Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys 
    1085                 1090                 1095             


Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu His Glu  His Ile Ala 
    1100                 1105                 1110             


Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr 
    1115                 1120                 1125             


Val Lys  Val Val Asp Glu Leu  Val Lys Val Met Gly  Arg His Lys 
    1130                 1135                 1140             


Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr 
    1145                 1150                 1155             


Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
    1160                 1165                 1170             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1175                 1180                 1185             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1190                 1195                 1200             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1205                 1210                 1215             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His Ile Val  Pro Gln Ser 
    1220                 1225                 1230             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1235                 1240                 1245             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1250                 1255                 1260             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1265                 1270                 1275             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    1280                 1285                 1290             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    1295                 1300                 1305             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1310                 1315                 1320             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1325                 1330                 1335             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1340                 1345                 1350             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1355                 1360                 1365             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1370                 1375                 1380             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1385                 1390                 1395             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1400                 1405                 1410             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1415                 1420                 1425             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1430                 1435                 1440             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1445                 1450                 1455             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1460                 1465                 1470             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1475                 1480                 1485             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1490                 1495                 1500             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1505                 1510                 1515             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1520                 1525                 1530             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1535                 1540                 1545             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1550                 1555                 1560             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1565                 1570                 1575             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1580                 1585                 1590             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1595                 1600                 1605             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1610                 1615                 1620             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1625                 1630                 1635             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1640                 1645                 1650             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1655                 1660                 1665             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1670                 1675                 1680             


Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile 
    1685                 1690                 1695             


His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys 
    1700                 1705                 1710             


Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys 
    1715                 1720                 1725             


Glu Val  Leu Asp Ala Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1730                 1735                 1740             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly 
    1745                 1750                 1755             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1760                 1765         


<210>  474
<211>  1767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  474

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Leu Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
385                 390                 395                 400 


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
                405                 410                 415     


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
            420                 425                 430         


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
        435                 440                 445             


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
    450                 455                 460                 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
465                 470                 475                 480 


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
                485                 490                 495     


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
            500                 505                 510         


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
        515                 520                 525             


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
    530                 535                 540                 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
545                 550                 555                 560 


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
                565                 570                 575     


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
            580                 585                 590         


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
        595                 600                 605             


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
    610                 615                 620                 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
625                 630                 635                 640 


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
                645                 650                 655     


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
            660                 665                 670         


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
        675                 680                 685             


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
    690                 695                 700                 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
705                 710                 715                 720 


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
                725                 730                 735     


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
            740                 745                 750         


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
        755                 760                 765             


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
    770                 775                 780                 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
785                 790                 795                 800 


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
                805                 810                 815     


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
            820                 825                 830         


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
        835                 840                 845             


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
    850                 855                 860                 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
865                 870                 875                 880 


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
                885                 890                 895     


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
            900                 905                 910         


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
        915                 920                 925             


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
    930                 935                 940                 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
945                 950                 955                 960 


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
                965                 970                 975     


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
            980                 985                 990         


Asp Phe Leu Asp Asn Glu Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val 
        995                 1000                 1005             


Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg 
    1010                 1015                 1020             


Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp Lys Val  Met Lys Gln 
    1025                 1030                 1035             


Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys 
    1040                 1045                 1050             


Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln 
    1070                 1075                 1080             


Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys 
    1085                 1090                 1095             


Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu His Glu  His Ile Ala 
    1100                 1105                 1110             


Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr 
    1115                 1120                 1125             


Val Lys  Val Val Asp Glu Leu  Val Lys Val Met Gly  Arg His Lys 
    1130                 1135                 1140             


Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr 
    1145                 1150                 1155             


Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
    1160                 1165                 1170             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1175                 1180                 1185             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1190                 1195                 1200             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1205                 1210                 1215             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His Ile Val  Pro Gln Ser 
    1220                 1225                 1230             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1235                 1240                 1245             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1250                 1255                 1260             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1265                 1270                 1275             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    1280                 1285                 1290             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    1295                 1300                 1305             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1310                 1315                 1320             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1325                 1330                 1335             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1340                 1345                 1350             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1355                 1360                 1365             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1370                 1375                 1380             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1385                 1390                 1395             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1400                 1405                 1410             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1415                 1420                 1425             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1430                 1435                 1440             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1445                 1450                 1455             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1460                 1465                 1470             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1475                 1480                 1485             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1490                 1495                 1500             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1505                 1510                 1515             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1520                 1525                 1530             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1535                 1540                 1545             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1550                 1555                 1560             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1565                 1570                 1575             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1580                 1585                 1590             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1595                 1600                 1605             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1610                 1615                 1620             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1625                 1630                 1635             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1640                 1645                 1650             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1655                 1660                 1665             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1670                 1675                 1680             


Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile 
    1685                 1690                 1695             


His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys 
    1700                 1705                 1710             


Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys 
    1715                 1720                 1725             


Glu Val  Leu Asp Ala Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1730                 1735                 1740             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly 
    1745                 1750                 1755             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1760                 1765         


<210>  475
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  475

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ser Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  476
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  476

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Leu Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Asn Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  477
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  477

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Leu Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Asn Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  478
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  478

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  479
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  479

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Leu Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile 
        35                  40                  45              


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  480
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  480

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ser Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Asn Ala Leu Leu Cys Tyr Phe Phe Arg Met Arg Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  481
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  481
gacctttggt cgcccggcct                                                   20


<210>  482
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  482

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  483
<211>  1800
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  483

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg 
            20                  25                  30          


His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro 
        35                  40                  45              


Val Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp 
    50                  55                  60                  


Asn Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met 
65                  70                  75                  80  


Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp 
                85                  90                  95      


Ala Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala 
            100                 105                 110         


Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala 
        115                 120                 125             


Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly 
    130                 135                 140                 


Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys 
145                 150                 155                 160 


Ala Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys 
                165                 170                 175     


Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly 
            180                 185                 190         


Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
        195                 200                 205             


Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser 
    210                 215                 220                 


His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg 
225                 230                 235                 240 


Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg 
                245                 250                 255     


Val Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr 
            260                 265                 270         


Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln 
        275                 280                 285             


Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys 
    290                 295                 300                 


Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val 
305                 310                 315                 320 


Phe Gly Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp 
                325                 330                 335     


Val Leu His Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly 
            340                 345                 350         


Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met 
        355                 360                 365             


Pro Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp 
    370                 375                 380                 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
385                 390                 395                 400 


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
                405                 410                 415     


Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
            420                 425                 430         


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
        435                 440                 445             


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
    450                 455                 460                 


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
465                 470                 475                 480 


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
                485                 490                 495     


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
            500                 505                 510         


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
        515                 520                 525             


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
    530                 535                 540                 


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
545                 550                 555                 560 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
                565                 570                 575     


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
            580                 585                 590         


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
        595                 600                 605             


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
    610                 615                 620                 


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
625                 630                 635                 640 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
                645                 650                 655     


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
            660                 665                 670         


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
        675                 680                 685             


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
    690                 695                 700                 


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
705                 710                 715                 720 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
                725                 730                 735     


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
            740                 745                 750         


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
        755                 760                 765             


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
    770                 775                 780                 


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
785                 790                 795                 800 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
                805                 810                 815     


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
            820                 825                 830         


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
        835                 840                 845             


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
    850                 855                 860                 


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
865                 870                 875                 880 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
                885                 890                 895     


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
            900                 905                 910         


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
        915                 920                 925             


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
    930                 935                 940                 


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
945                 950                 955                 960 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
                965                 970                 975     


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
            980                 985                 990         


Val Glu Ile Ser Gly Val Glu Asp  Arg Phe Asn Ala Ser  Leu Gly Thr 
        995                 1000                 1005             


Tyr His  Asp Leu Leu Lys Ile  Ile Lys Asp Lys Asp  Phe Leu Asp 
    1010                 1015                 1020             


Asn Glu  Glu Asn Glu Asp Ile  Leu Glu Asp Ile Val  Leu Thr Leu 
    1025                 1030                 1035             


Thr Leu  Phe Glu Asp Arg Glu  Met Ile Glu Glu Arg  Leu Lys Thr 
    1040                 1045                 1050             


Tyr Ala  His Leu Phe Asp Asp  Lys Val Met Lys Gln  Leu Lys Arg 
    1055                 1060                 1065             


Arg Arg  Tyr Thr Gly Trp Gly  Arg Leu Ser Arg Lys  Leu Ile Asn 
    1070                 1075                 1080             


Gly Ile  Arg Asp Lys Gln Ser  Gly Lys Thr Ile Leu  Asp Phe Leu 
    1085                 1090                 1095             


Lys Ser  Asp Gly Phe Ala Asn  Arg Asn Phe Met Gln  Leu Ile His 
    1100                 1105                 1110             


Asp Asp  Ser Leu Thr Phe Lys  Glu Asp Ile Gln Lys  Ala Gln Val 
    1115                 1120                 1125             


Ser Gly  Gln Gly Asp Ser Leu  His Glu His Ile Ala  Asn Leu Ala 
    1130                 1135                 1140             


Gly Ser  Pro Ala Ile Lys Lys  Gly Ile Leu Gln Thr  Val Lys Val 
    1145                 1150                 1155             


Val Asp  Glu Leu Val Lys Val  Met Gly Arg His Lys  Pro Glu Asn 
    1160                 1165                 1170             


Ile Val  Ile Glu Met Ala Arg  Glu Asn Gln Thr Thr  Gln Lys Gly 
    1175                 1180                 1185             


Gln Lys  Asn Ser Arg Glu Arg  Met Lys Arg Ile Glu  Glu Gly Ile 
    1190                 1195                 1200             


Lys Glu  Leu Gly Ser Gln Ile  Leu Lys Glu His Pro  Val Glu Asn 
    1205                 1210                 1215             


Thr Gln  Leu Gln Asn Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn 
    1220                 1225                 1230             


Gly Arg  Asp Met Tyr Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu 
    1235                 1240                 1245             


Ser Asp  Tyr Asp Val Asp His  Ile Val Pro Gln Ser  Phe Leu Lys 
    1250                 1255                 1260             


Asp Asp  Ser Ile Asp Asn Lys  Val Leu Thr Arg Ser  Asp Lys Asn 
    1265                 1270                 1275             


Arg Gly  Lys Ser Asp Asn Val  Pro Ser Glu Glu Val  Val Lys Lys 
    1280                 1285                 1290             


Met Lys  Asn Tyr Trp Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr 
    1295                 1300                 1305             


Gln Arg  Lys Phe Asp Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu 
    1310                 1315                 1320             


Ser Glu  Leu Asp Lys Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu 
    1325                 1330                 1335             


Thr Arg  Gln Ile Thr Lys His  Val Ala Gln Ile Leu  Asp Ser Arg 
    1340                 1345                 1350             


Met Asn  Thr Lys Tyr Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val 
    1355                 1360                 1365             


Lys Val  Ile Thr Leu Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys 
    1370                 1375                 1380             


Asp Phe  Gln Phe Tyr Lys Val  Arg Glu Ile Asn Asn  Tyr His His 
    1385                 1390                 1395             


Ala His  Asp Ala Tyr Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile 
    1400                 1405                 1410             


Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr 
    1415                 1420                 1425             


Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu 
    1430                 1435                 1440             


Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met 
    1445                 1450                 1455             


Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg 
    1460                 1465                 1470             


Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val 
    1475                 1480                 1485             


Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser 
    1490                 1495                 1500             


Met Pro  Gln Val Asn Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly 
    1505                 1510                 1515             


Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys 
    1520                 1525                 1530             


Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly 
    1535                 1540                 1545             


Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val Leu Val  Val Ala Lys 
    1550                 1555                 1560             


Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu 
    1565                 1570                 1575             


Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro 
    1580                 1585                 1590             


Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp 
    1595                 1600                 1605             


Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn 
    1610                 1615                 1620             


Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly 
    1625                 1630                 1635             


Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu 
    1640                 1645                 1650             


Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu 
    1655                 1660                 1665             


Gln Lys  Gln Leu Phe Val Glu  Gln His Lys His Tyr  Leu Asp Glu 
    1670                 1675                 1680             


Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala 
    1685                 1690                 1695             


Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg 
    1700                 1705                 1710             


Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe 
    1715                 1720                 1725             


Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp 
    1730                 1735                 1740             


Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu 
    1745                 1750                 1755             


Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr 
    1760                 1765                 1770             


Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp Lys Arg  Thr Ala Asp 
    1775                 1780                 1785             


Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg Lys Val  
    1790                 1795                 1800 


<210>  484
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  484
gagttggcca ctccctctct gc                                                22


<210>  485
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  485
agaacggcat caaggtgaac                                                   20


<210>  486
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  486
gaactccagc aggaccatgt                                                   20


<210>  487
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  487

Met Thr Asp Ala Glu Tyr Val Arg Ile His Glu Lys Leu Asp Ile Tyr 
1               5                   10                  15      


Thr Phe Lys Lys Gln Phe Ser Asn Asn Lys Lys Ser Val Ser His Arg 
            20                  25                  30          


Cys Tyr Val Leu Phe Glu Leu Lys Arg Arg Gly Glu Arg Arg Ala Cys 
        35                  40                  45              


Phe Trp Gly Tyr Ala Val Asn Lys Pro Gln Ser Gly Thr Glu Arg Gly 
    50                  55                  60                  


Ile His Ala Glu Ile Phe Ser Ile Arg Lys Val Glu Glu Tyr Leu Arg 
65                  70                  75                  80  


Asp Asn Pro Gly Gln Phe Thr Ile Asn Trp Tyr Ser Ser Trp Ser Pro 
                85                  90                  95      


Cys Ala Asp Cys Ala Glu Lys Ile Leu Glu Trp Tyr Asn Gln Glu Leu 
            100                 105                 110         


Arg Gly Asn Gly His Thr Leu Lys Ile Trp Val Cys Lys Leu Tyr Tyr 
        115                 120                 125             


Glu Lys Asn Ala Arg Asn Gln Ile Gly Leu Trp Asn Leu Arg Asp Asn 
    130                 135                 140                 


Gly Val Gly Leu Asn Val Met Val Ser Glu His Tyr Gln Cys Cys Arg 
145                 150                 155                 160 


Lys Ile Phe Ile Gln Ser Ser His Asn Gln Leu Asn Glu Asn Arg Trp 
                165                 170                 175     


Leu Glu Lys Thr Leu Lys Arg Ala Glu Lys Arg Arg Ser Glu Leu Ser 
            180                 185                 190         


Ile Met Phe Gln Val Lys Ile Leu His Thr Thr Lys Ser Pro Ala Val 
        195                 200                 205             


<210>  488
<211>  1368
<212>  PRT
<213>  S. pyogenes

<400>  488

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Val  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Arg 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Gln  Tyr Arg Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  489
<211>  1794
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  489

Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr 
        35                  40                  45              


Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Thr Leu Gly Leu Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
        195                 200                 205             


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly 
    210                 215                 220                 


Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile 
225                 230                 235                 240 


Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val 
                245                 250                 255     


Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile 
            260                 265                 270         


Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala 
        275                 280                 285             


Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg 
    290                 295                 300                 


Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala 
305                 310                 315                 320 


Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val 
                325                 330                 335     


Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val 
            340                 345                 350         


Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg 
        355                 360                 365             


Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr 
    370                 375                 380                 


Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu 
385                 390                 395                 400 


Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln 
                405                 410                 415     


Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala 
            420                 425                 430         


Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser 
        435                 440                 445             


Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn 
    450                 455                 460                 


Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn 
465                 470                 475                 480 


Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser 
                485                 490                 495     


Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly 
            500                 505                 510         


Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala 
        515                 520                 525             


Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala 
    530                 535                 540                 


Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp 
545                 550                 555                 560 


Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr 
                565                 570                 575     


Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile 
            580                 585                 590         


Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile 
        595                 600                 605             


Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg 
    610                 615                 620                 


Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro 
625                 630                 635                 640 


His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu 
                645                 650                 655     


Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile 
            660                 665                 670         


Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn 
        675                 680                 685             


Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro 
    690                 695                 700                 


Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe 
705                 710                 715                 720 


Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val 
                725                 730                 735     


Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu 
            740                 745                 750         


Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe 
        755                 760                 765             


Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr 
    770                 775                 780                 


Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys 
785                 790                 795                 800 


Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe 
                805                 810                 815     


Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp 
            820                 825                 830         


Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile 
        835                 840                 845             


Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg 
    850                 855                 860                 


Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu 
865                 870                 875                 880 


Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile 
                885                 890                 895     


Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu 
            900                 905                 910         


Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp 
        915                 920                 925             


Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly 
    930                 935                 940                 


Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro 
945                 950                 955                 960 


Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu 
                965                 970                 975     


Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met 
            980                 985                 990         


Ala Arg Glu Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
        995                 1000                 1005             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1010                 1015                 1020             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1025                 1030                 1035             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1040                 1045                 1050             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1055                 1060                 1065             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1070                 1075                 1080             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1085                 1090                 1095             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1100                 1105                 1110             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1115                 1120                 1125             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1130                 1135                 1140             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1145                 1150                 1155             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1160                 1165                 1170             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1175                 1180                 1185             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1190                 1195                 1200             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1205                 1210                 1215             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1220                 1225                 1230             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1235                 1240                 1245             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1250                 1255                 1260             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1265                 1270                 1275             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1280                 1285                 1290             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1295                 1300                 1305             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1310                 1315                 1320             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1325                 1330                 1335             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1340                 1345                 1350             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1355                 1360                 1365             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1370                 1375                 1380             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1385                 1390                 1395             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1400                 1405                 1410             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1415                 1420                 1425             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1430                 1435                 1440             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1445                 1450                 1455             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1460                 1465                 1470             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1475                 1480                 1485             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1490                 1495                 1500             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1505                 1510                 1515             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1520                 1525                 1530             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1535                 1540                 1545             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1550                 1555                 1560             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1565                 1570                 1575             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1580                 1585                 1590             


Leu Gly  Gly Asp Ser Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Thr 
    1595                 1600                 1605             


Asn Leu  Ser Asp Ile Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val 
    1610                 1615                 1620             


Ile Gln  Glu Ser Ile Leu Met  Leu Pro Glu Glu Val  Glu Glu Val 
    1625                 1630                 1635             


Ile Gly  Asn Lys Pro Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr 
    1640                 1645                 1650             


Asp Glu  Ser Thr Asp Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala 
    1655                 1660                 1665             


Pro Glu  Tyr Lys Pro Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly 
    1670                 1675                 1680             


Glu Asn  Lys Ile Lys Met Leu  Ser Gly Gly Ser Gly  Gly Ser Gly 
    1685                 1690                 1695             


Gly Ser  Thr Asn Leu Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys 
    1700                 1705                 1710             


Gln Leu  Val Ile Gln Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val 
    1715                 1720                 1725             


Glu Glu  Val Ile Gly Asn Lys  Pro Glu Ser Asp Ile  Leu Val His 
    1730                 1735                 1740             


Thr Ala  Tyr Asp Glu Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr 
    1745                 1750                 1755             


Ser Asp  Ala Pro Glu Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp 
    1760                 1765                 1770             


Ser Asn  Gly Glu Asn Lys Ile  Lys Met Leu Ser Gly  Gly Ser Pro 
    1775                 1780                 1785             


Lys Lys  Lys Arg Lys Val 
    1790                 


<210>  490
<211>  1804
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  490

Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr 
        35                  40                  45              


Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Thr Leu Gly Leu Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
        195                 200                 205             


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly 
    210                 215                 220                 


Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile 
225                 230                 235                 240 


Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val 
                245                 250                 255     


Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile 
            260                 265                 270         


Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala 
        275                 280                 285             


Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg 
    290                 295                 300                 


Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala 
305                 310                 315                 320 


Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val 
                325                 330                 335     


Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val 
            340                 345                 350         


Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg 
        355                 360                 365             


Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr 
    370                 375                 380                 


Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu 
385                 390                 395                 400 


Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln 
                405                 410                 415     


Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala 
            420                 425                 430         


Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser 
        435                 440                 445             


Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn 
    450                 455                 460                 


Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn 
465                 470                 475                 480 


Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser 
                485                 490                 495     


Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly 
            500                 505                 510         


Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala 
        515                 520                 525             


Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala 
    530                 535                 540                 


Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp 
545                 550                 555                 560 


Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr 
                565                 570                 575     


Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile 
            580                 585                 590         


Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile 
        595                 600                 605             


Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg 
    610                 615                 620                 


Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro 
625                 630                 635                 640 


His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu 
                645                 650                 655     


Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile 
            660                 665                 670         


Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn 
        675                 680                 685             


Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro 
    690                 695                 700                 


Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe 
705                 710                 715                 720 


Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val 
                725                 730                 735     


Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu 
            740                 745                 750         


Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe 
        755                 760                 765             


Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr 
    770                 775                 780                 


Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys 
785                 790                 795                 800 


Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe 
                805                 810                 815     


Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp 
            820                 825                 830         


Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile 
        835                 840                 845             


Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg 
    850                 855                 860                 


Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu 
865                 870                 875                 880 


Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile 
                885                 890                 895     


Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu 
            900                 905                 910         


Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp 
        915                 920                 925             


Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly 
    930                 935                 940                 


Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro 
945                 950                 955                 960 


Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu 
                965                 970                 975     


Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met 
            980                 985                 990         


Ala Arg Glu Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
        995                 1000                 1005             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1010                 1015                 1020             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1025                 1030                 1035             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1040                 1045                 1050             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1055                 1060                 1065             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1070                 1075                 1080             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1085                 1090                 1095             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1100                 1105                 1110             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1115                 1120                 1125             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1130                 1135                 1140             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1145                 1150                 1155             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1160                 1165                 1170             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1175                 1180                 1185             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1190                 1195                 1200             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1205                 1210                 1215             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1220                 1225                 1230             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1235                 1240                 1245             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1250                 1255                 1260             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1265                 1270                 1275             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1280                 1285                 1290             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1295                 1300                 1305             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1310                 1315                 1320             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1325                 1330                 1335             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1340                 1345                 1350             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Val Ser  Pro Thr Val 
    1355                 1360                 1365             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1370                 1375                 1380             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1385                 1390                 1395             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1400                 1405                 1410             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1415                 1420                 1425             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1430                 1435                 1440             


Ala Ser  Ala Arg Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1445                 1450                 1455             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1460                 1465                 1470             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1475                 1480                 1485             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1490                 1495                 1500             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1505                 1510                 1515             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1520                 1525                 1530             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1535                 1540                 1545             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1550                 1555                 1560             


Gln Tyr  Arg Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1565                 1570                 1575             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1580                 1585                 1590             


Leu Gly  Gly Asp Ser Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Thr 
    1595                 1600                 1605             


Asn Leu  Ser Asp Ile Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val 
    1610                 1615                 1620             


Ile Gln  Glu Ser Ile Leu Met  Leu Pro Glu Glu Val  Glu Glu Val 
    1625                 1630                 1635             


Ile Gly  Asn Lys Pro Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr 
    1640                 1645                 1650             


Asp Glu  Ser Thr Asp Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala 
    1655                 1660                 1665             


Pro Glu  Tyr Lys Pro Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly 
    1670                 1675                 1680             


Glu Asn  Lys Ile Lys Met Leu  Ser Gly Gly Ser Gly  Gly Ser Gly 
    1685                 1690                 1695             


Gly Ser  Thr Asn Leu Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys 
    1700                 1705                 1710             


Gln Leu  Val Ile Gln Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val 
    1715                 1720                 1725             


Glu Glu  Val Ile Gly Asn Lys  Pro Glu Ser Asp Ile  Leu Val His 
    1730                 1735                 1740             


Thr Ala  Tyr Asp Glu Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr 
    1745                 1750                 1755             


Ser Asp  Ala Pro Glu Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp 
    1760                 1765                 1770             


Ser Asn  Gly Glu Asn Lys Ile  Lys Met Leu Ser Gly  Gly Ser Lys 
    1775                 1780                 1785             


Arg Thr  Ala Asp Gly Ser Glu  Phe Glu Pro Lys Lys  Lys Arg Lys 
    1790                 1795                 1800             


Val 
    


<210>  491
<211>  171
<212>  PRT
<213>  S. pyogenes

<400>  491

Met Pro Tyr Ser Leu Glu Glu Gln Thr Tyr Phe Met Gln Glu Ala Leu 
1               5                   10                  15      


Lys Glu Ala Glu Lys Ser Leu Gln Lys Ala Glu Ile Pro Ile Gly Cys 
            20                  25                  30          


Val Ile Val Lys Asp Gly Glu Ile Ile Gly Arg Gly His Asn Ala Arg 
        35                  40                  45              


Glu Glu Ser Asn Gln Ala Ile Met His Ala Glu Ile Met Ala Ile Asn 
    50                  55                  60                  


Glu Ala Asn Ala His Glu Gly Asn Trp Arg Leu Leu Asp Thr Thr Leu 
65                  70                  75                  80  


Phe Val Thr Ile Glu Pro Cys Val Met Cys Ser Gly Ala Ile Gly Leu 
                85                  90                  95      


Ala Arg Ile Pro His Val Ile Tyr Gly Ala Ser Asn Gln Lys Phe Gly 
            100                 105                 110         


Gly Ala Asp Ser Leu Tyr Gln Ile Leu Thr Asp Glu Arg Leu Asn His 
        115                 120                 125             


Arg Val Gln Val Glu Arg Gly Leu Leu Ala Ala Asp Cys Ala Asn Ile 
    130                 135                 140                 


Met Gln Thr Phe Phe Arg Gln Gly Arg Glu Arg Lys Lys Ile Ala Lys 
145                 150                 155                 160 


His Leu Ile Lys Glu Gln Ser Asp Pro Phe Asp 
                165                 170     


<210>  492
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  492

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile 
        35                  40                  45              


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  493
<211>  166
<212>  PRT
<213>  E. coli

<400>  493

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile 
        35                  40                  45              


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Trp Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  494
<211>  166
<212>  PRT
<213>  E. coli

<400>  494

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile 
        35                  40                  45              


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys Arg Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Ile Asn 
                165     


<210>  495
<211>  166
<212>  PRT
<213>  E. coli

<400>  495

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile 
        35                  40                  45              


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Trp Arg Asn Ser Lys Arg Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Ile Asn 
                165     


<210>  496
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  496
tggagttcag acgtgtgctc ttccgatctc actgaaactt gccatcgcc                   49


<210>  497
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  497
acactctttc cctacacgac gctcttccga tctnnnntct gaacaggtta gagggtgc         58


<210>  498
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  498
tggagttcag acgtgtgctc ttccgatcta attcctaagt tccagggagt c                51


<210>  499
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  499
acactctttc cctacacgac gctcttccga tctnnnngct cattctaaaa ttcatagcct       60


<210>  500
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  500
tggagttcag acgtgtgctc ttccgatctt agcatgctgg gaaccagac                   49


<210>  501
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  501
acactctttc cctacacgac gctcttccga tctnnnnagg tcctagggtc attcggg          57


<210>  502
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  502
tggagttcag acgtgtgctc ttccgatcta gtagccttca gctgccaac                   49


<210>  503
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  503
acactctttc cctacacgac gctcttccga tctnnnngcc tctgactgtg tggcaag          57


<210>  504
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  504
tggagttcag acgtgtgctc ttccgatcta cattgccttc tccactcttc c                51


<210>  505
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  505
acactctttc cctacacgac gctcttccga tctnnnnacc agggcatgtc atgaaaac         58


<210>  506
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  506
tggagttcag acgtgtgctc ttccgatctc aggagcacac ctatcaggc                   49


<210>  507
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  507
acactctttc cctacacgac gctcttccga tctnnnnact agagccacta ggaagaggg        59


<210>  508
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  508
tggagttcag acgtgtgctc ttccgatctt tctagcttgc tcctgggct                   49


<210>  509
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  509
ccacctgagg aataggaagt acgaggccac tgaggaac                               38


<210>  510
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  510
ccacctgagg aataggaagt atgaggccac tgaggaac                               38


<210>  511
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  511
ccacctgagg aacaggaagt acgaggccac tgaggaac                               38


<210>  512
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  512
ccacctgagg aacaggaagt atgaggccac tgaggaac                               38


<210>  513
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  513
aacaggaagc acgaggccac                                                   20


<210>  514
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  514

Gly Ser His Met Thr Asn Asp Ile Tyr Phe Met Thr Leu Ala Ile Glu 
1               5                   10                  15      


Glu Ala Lys Lys Ala Ala Gln Leu Gly Glu Val Pro Ile Gly Ala Ile 
            20                  25                  30          


Ile Thr Lys Asp Asp Glu Val Ile Ala Arg Ala His Asn Leu Arg Glu 
        35                  40                  45              


Thr Leu Gln Gln Pro Thr Ala His Ala Glu His Ile Ala Ile Glu Arg 
    50                  55                  60                  


Ala Ala Lys Val Leu Gly Ser Trp Arg Leu Glu Gly Cys Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Thr Ile Val Met Ser 
                85                  90                  95      


Arg Ile Pro Arg Val Val Tyr Gly Ala Ala Asn Pro Lys Gly Gly Cys 
            100                 105                 110         


Ser Gly Ser Leu Met Asn Leu Leu Gln Gln Ser Asn Phe Asn His Arg 
        115                 120                 125             


Ala Ile Val Asp Lys Gly Val Leu Lys Glu Ala Cys Ala Thr Leu Leu 
    130                 135                 140                 


Thr Thr Phe Phe Lys Asn Leu Arg Ala Asn Lys Lys Ser Thr Asn 
145                 150                 155                 


<210>  515
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  515

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Lys Trp Gly Thr 
    50                  55                  60                  


Ser His Lys Ile Trp Arg His Ser Ser Lys Asn Thr Thr Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Ser Glu Arg His Phe Cys Pro 
                85                  90                  95      


Ser Thr Ser Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Lys Ala Ile Thr Glu Phe Leu Ser Gln His Pro Asn Val 
        115                 120                 125             


Thr Leu Val Ile Tyr Val Ala Arg Leu Tyr His His Met Asp Gln Gln 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Val Asn Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Ala Pro Glu Tyr Asp Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Pro Pro Gly Lys Glu Ala His Trp Pro Arg Tyr Pro Pro Leu Trp 
            180                 185                 190         


Met Lys Leu Tyr Ala Leu Glu Leu His Ala Gly Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  516
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  516

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Tyr Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Glu 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  517
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  517

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Tyr Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Glu Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  518
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  518

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Tyr Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Glu 
    130                 135                 140                 


Asn Arg Gln Gly Leu Glu Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  519
<211>  1082
<212>  PRT
<213>  Geobacillus thermodenitrificans

<400>  519

Met Lys Tyr Lys Ile Gly Leu Asp Ile Gly Ile Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Leu Asp Ile Pro Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Ile Phe Asp Arg Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu 
        35                  40                  45              


Pro Arg Arg Leu Ala Arg Ser Ala Arg Arg Arg Leu Arg Arg Arg Lys 
    50                  55                  60                  


His Arg Leu Glu Arg Ile Arg Arg Leu Phe Val Arg Glu Gly Ile Leu 
65                  70                  75                  80  


Thr Lys Glu Glu Leu Asn Lys Leu Phe Glu Lys Lys His Glu Ile Asp 
                85                  90                  95      


Val Trp Gln Leu Arg Val Glu Ala Leu Asp Arg Lys Leu Asn Asn Asp 
            100                 105                 110         


Glu Leu Ala Arg Ile Leu Leu His Leu Ala Lys Arg Arg Gly Phe Arg 
        115                 120                 125             


Ser Asn Arg Lys Ser Glu Arg Thr Asn Lys Glu Asn Ser Thr Met Leu 
    130                 135                 140                 


Lys His Ile Glu Glu Asn Gln Ser Ile Leu Ser Ser Tyr Arg Thr Val 
145                 150                 155                 160 


Ala Glu Met Val Val Lys Asp Pro Lys Phe Ser Leu His Lys Arg Asn 
                165                 170                 175     


Lys Glu Asp Asn Tyr Thr Asn Thr Val Ala Arg Asp Asp Leu Glu Arg 
            180                 185                 190         


Glu Ile Lys Leu Ile Phe Ala Lys Gln Arg Glu Tyr Gly Asn Ile Val 
        195                 200                 205             


Cys Thr Glu Ala Phe Glu His Glu Tyr Ile Ser Ile Trp Ala Ser Gln 
    210                 215                 220                 


Arg Pro Phe Ala Ser Lys Asp Asp Ile Glu Lys Lys Val Gly Phe Cys 
225                 230                 235                 240 


Thr Phe Glu Pro Lys Glu Lys Arg Ala Pro Lys Ala Thr Tyr Thr Phe 
                245                 250                 255     


Gln Ser Phe Thr Val Trp Glu His Ile Asn Lys Leu Arg Leu Val Ser 
            260                 265                 270         


Pro Gly Gly Ile Arg Ala Leu Thr Asp Asp Glu Arg Arg Leu Ile Tyr 
        275                 280                 285             


Lys Gln Ala Phe His Lys Asn Lys Ile Thr Phe His Asp Val Arg Thr 
    290                 295                 300                 


Leu Leu Asn Leu Pro Asp Asp Thr Arg Phe Lys Gly Leu Leu Tyr Asp 
305                 310                 315                 320 


Arg Asn Thr Thr Leu Lys Glu Asn Glu Lys Val Arg Phe Leu Glu Leu 
                325                 330                 335     


Gly Ala Tyr His Lys Ile Arg Lys Ala Ile Asp Ser Val Tyr Gly Lys 
            340                 345                 350         


Gly Ala Ala Lys Ser Phe Arg Pro Ile Asp Phe Asp Thr Phe Gly Tyr 
        355                 360                 365             


Ala Leu Thr Met Phe Lys Asp Asp Thr Asp Ile Arg Ser Tyr Leu Arg 
    370                 375                 380                 


Asn Glu Tyr Glu Gln Asn Gly Lys Arg Met Glu Asn Leu Ala Asp Lys 
385                 390                 395                 400 


Val Tyr Asp Glu Glu Leu Ile Glu Glu Leu Leu Asn Leu Ser Phe Ser 
                405                 410                 415     


Lys Phe Gly His Leu Ser Leu Lys Ala Leu Arg Asn Ile Leu Pro Tyr 
            420                 425                 430         


Met Glu Gln Gly Glu Val Tyr Ser Thr Ala Cys Glu Arg Ala Gly Tyr 
        435                 440                 445             


Thr Phe Thr Gly Pro Lys Lys Lys Gln Lys Thr Val Leu Leu Pro Asn 
    450                 455                 460                 


Ile Pro Pro Ile Ala Asn Pro Val Val Met Arg Ala Leu Thr Gln Ala 
465                 470                 475                 480 


Arg Lys Val Val Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Val Ser 
                485                 490                 495     


Ile His Ile Glu Leu Ala Arg Glu Leu Ser Gln Ser Phe Asp Glu Arg 
            500                 505                 510         


Arg Lys Met Gln Lys Glu Gln Glu Gly Asn Arg Lys Lys Asn Glu Thr 
        515                 520                 525             


Ala Ile Arg Gln Leu Val Glu Tyr Gly Leu Thr Leu Asn Pro Thr Gly 
    530                 535                 540                 


Leu Asp Ile Val Lys Phe Lys Leu Trp Ser Glu Gln Asn Gly Lys Cys 
545                 550                 555                 560 


Ala Tyr Ser Leu Gln Pro Ile Glu Ile Glu Arg Leu Leu Glu Pro Gly 
                565                 570                 575     


Tyr Thr Glu Val Asp His Val Ile Pro Tyr Ser Arg Ser Leu Asp Asp 
            580                 585                 590         


Ser Tyr Thr Asn Lys Val Leu Val Leu Thr Lys Glu Asn Arg Glu Lys 
        595                 600                 605             


Gly Asn Arg Thr Pro Ala Glu Tyr Leu Gly Leu Gly Ser Glu Arg Trp 
    610                 615                 620                 


Gln Gln Phe Glu Thr Phe Val Leu Thr Asn Lys Gln Phe Ser Lys Lys 
625                 630                 635                 640 


Lys Arg Asp Arg Leu Leu Arg Leu His Tyr Asp Glu Asn Glu Glu Asn 
                645                 650                 655     


Glu Phe Lys Asn Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ser Arg Phe 
            660                 665                 670         


Leu Ala Asn Phe Ile Arg Glu His Leu Lys Phe Ala Asp Ser Asp Asp 
        675                 680                 685             


Lys Gln Lys Val Tyr Thr Val Asn Gly Arg Ile Thr Ala His Leu Arg 
    690                 695                 700                 


Ser Arg Trp Asn Phe Asn Lys Asn Arg Glu Glu Ser Asn Leu His His 
705                 710                 715                 720 


Ala Val Asp Ala Ala Ile Val Ala Cys Thr Thr Pro Ser Asp Ile Ala 
                725                 730                 735     


Arg Val Thr Ala Phe Tyr Gln Arg Arg Glu Gln Asn Lys Glu Leu Ser 
            740                 745                 750         


Lys Lys Thr Asp Pro Gln Phe Pro Gln Pro Trp Pro His Phe Ala Asp 
        755                 760                 765             


Glu Leu Gln Ala Arg Leu Ser Lys Asn Pro Lys Glu Ser Ile Lys Ala 
    770                 775                 780                 


Leu Asn Leu Gly Asn Tyr Asp Asn Glu Lys Leu Glu Ser Leu Gln Pro 
785                 790                 795                 800 


Val Phe Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Ala Ala His 
                805                 810                 815     


Gln Glu Thr Leu Arg Arg Tyr Ile Gly Ile Asp Glu Arg Ser Gly Lys 
            820                 825                 830         


Ile Gln Thr Val Val Lys Lys Lys Leu Ser Glu Ile Gln Leu Asp Lys 
        835                 840                 845             


Thr Gly His Phe Pro Met Tyr Gly Lys Glu Ser Asp Pro Arg Thr Tyr 
    850                 855                 860                 


Glu Ala Ile Arg Gln Arg Leu Leu Glu His Asn Asn Asp Pro Lys Lys 
865                 870                 875                 880 


Ala Phe Gln Glu Pro Leu Tyr Lys Pro Lys Lys Asn Gly Glu Leu Gly 
                885                 890                 895     


Pro Ile Ile Arg Thr Ile Lys Ile Ile Asp Thr Thr Asn Gln Val Ile 
            900                 905                 910         


Pro Leu Asn Asp Gly Lys Thr Val Ala Tyr Asn Ser Asn Ile Val Arg 
        915                 920                 925             


Val Asp Val Phe Glu Lys Asp Gly Lys Tyr Tyr Cys Val Pro Ile Tyr 
    930                 935                 940                 


Thr Ile Asp Met Met Lys Gly Ile Leu Pro Asn Lys Ala Ile Glu Pro 
945                 950                 955                 960 


Asn Lys Pro Tyr Ser Glu Trp Lys Glu Met Thr Glu Asp Tyr Thr Phe 
                965                 970                 975     


Arg Phe Ser Leu Tyr Pro Asn Asp Leu Ile Arg Ile Glu Phe Pro Arg 
            980                 985                 990         


Glu Lys Thr Ile Lys Thr Ala Val  Gly Glu Glu Ile Lys  Ile Lys Asp 
        995                 1000                 1005             


Leu Phe  Ala Tyr Tyr Gln Thr  Ile Asp Ser Ser Asn  Gly Gly Leu 
    1010                 1015                 1020             


Ser Leu  Val Ser His Asp Asn  Asn Phe Ser Leu Arg  Ser Ile Gly 
    1025                 1030                 1035             


Ser Arg  Thr Leu Lys Arg Phe  Glu Lys Tyr Gln Val  Asp Val Leu 
    1040                 1045                 1050             


Gly Asn  Ile Tyr Lys Val Arg  Gly Glu Lys Arg Val  Gly Val Ala 
    1055                 1060                 1065             


Ser Ser  Ser His Ser Lys Ala  Gly Glu Thr Ile Arg  Pro Leu 
    1070                 1075                 1080         


<210>  520
<211>  1375
<212>  PRT
<213>  S. Canis

<400>  520

Met Glu Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asn Arg Lys Ser Ile Lys Lys Asn Leu Met 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Asn Glu Met Ala Lys Leu Asp Asp Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


Asn Glu Arg His Pro Ile Phe Gly Asn Leu Ala Asp Glu Val Ala Tyr 
        115                 120                 125             


His Arg Asn Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Pro Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asn Ala 
                165                 170                 175     


Glu Asn Ser Asp Val Ala Lys Leu Phe Tyr Gln Leu Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Ser Pro Leu Asp Glu Ile Glu Val Asp Ala 
        195                 200                 205             


Lys Gly Ile Leu Ser Ala Arg Leu Ser Lys Ser Lys Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Ala Val Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Ile Ile Ala Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Thr Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Glu Leu Leu Gly Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ser Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Ser Asn Ser Glu Val Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Asp Glu His His Gln Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Thr Leu Val Arg Gln Gln Phe Pro Glu Lys Tyr Ala Glu Ile Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ile Gly Ile Lys 
        355                 360                 365             


His Arg Lys Arg Thr Thr Lys Leu Ala Thr Gln Glu Glu Phe Tyr Lys 
    370                 375                 380                 


Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Ala Glu Glu Leu Leu 
385                 390                 395                 400 


Ala Lys Leu Asn Arg Asp Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Ser Ile Pro His Gln Ile His Leu Lys Glu Leu His Ala Ile 
            420                 425                 430         


Leu Arg Arg Gln Glu Glu Phe Tyr Pro Phe Leu Lys Glu Asn Arg Glu 
        435                 440                 445             


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Leu Thr Arg Lys Ser Glu 
465                 470                 475                 480 


Glu Ala Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala 
                485                 490                 495     


Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Glu Gln Leu 
            500                 505                 510         


Pro Asn Lys Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe 
        515                 520                 525             


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Arg Met 
    530                 535                 540                 


Arg Lys Pro Glu Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp 
545                 550                 555                 560 


Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu 
                565                 570                 575     


Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ile Gly 
            580                 585                 590         


Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu 
        595                 600                 605             


Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp 
    610                 615                 620                 


Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 
625                 630                 635                 640 


Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys 
                645                 650                 655     


Val Met Lys Gln Leu Lys Arg Arg His Tyr Thr Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Arg Lys Met Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr 
        675                 680                 685             


Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ser Asn Arg Asn Phe Met 
    690                 695                 700                 


Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Glu Ile Glu Lys 
705                 710                 715                 720 


Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu Gln Ile Ala Asp 
                725                 730                 735     


Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys 
            740                 745                 750         


Ile Val Asp Glu Leu Val Lys Val Met Gly His Lys Pro Glu Asn Ile 
        755                 760                 765             


Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Thr Lys Gly Leu Gln 
    770                 775                 780                 


Gln Ser Arg Glu Arg Lys Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu 
785                 790                 795                 800 


Glu Ser Gln Ile Leu Lys Glu Asn Pro Val Glu Asn Thr Gln Leu Gln 
                805                 810                 815     


Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr 
            820                 825                 830         


Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp 
        835                 840                 845             


His Ile Val Pro Gln Ser Phe Ile Lys Asp Asp Ser Ile Asp Asn Lys 
    850                 855                 860                 


Val Leu Thr Arg Ser Val Glu Asn Arg Gly Lys Ser Asp Asn Val Pro 
865                 870                 875                 880 


Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu 
                885                 890                 895     


Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
            900                 905                 910         


Glu Arg Gly Gly Leu Ser Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu 
    930                 935                 940                 


Asp Ser Arg Met Asn Thr Lys Arg Asp Lys Asn Asp Lys Pro Ile Arg 
945                 950                 955                 960 


Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg 
                965                 970                 975     


Lys Asp Phe Gln Leu Tyr Lys Val Arg Asp Ile Asn Asn Tyr His His 
            980                 985                 990         


Ala His Asp Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
        995                 1000                 1005             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1010                 1015                 1020             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1025                 1030                 1035             


Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1040                 1045                 1050             


Phe Phe  Lys Thr Glu Val Lys  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1055                 1060                 1065             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Val Val Trp 
    1070                 1075                 1080             


Asn Lys  Glu Lys Asp Phe Ala  Thr Val Arg Lys Val  Leu Ala Met 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Ser Lys Arg Glu Ser  Ala Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Lys Gly Trp  Asp Thr Arg Lys Tyr  Gly Gly Phe 
    1130                 1135                 1140             


Gly Ser  Pro Thr Val Ala Tyr  Ser Ile Leu Val Val  Ala Lys Val 
    1145                 1150                 1155             


Glu Lys  Gly Lys Ala Lys Lys  Leu Lys Ser Val Lys  Val Leu Val 
    1160                 1165                 1170             


Gly Ile  Thr Ile Met Glu Lys  Gly Ser Tyr Glu Lys  Asp Pro Ile 
    1175                 1180                 1185             


Gly Phe  Leu Glu Ala Lys Gly  Tyr Lys Asp Ile Lys  Lys Glu Leu 
    1190                 1195                 1200             


Ile Phe  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1205                 1210                 1215             


Arg Arg  Arg Met Leu Ala Ser  Ala Thr Glu Leu Gln  Lys Ala Asn 
    1220                 1225                 1230             


Glu Leu  Val Leu Pro Gln His  Leu Val Arg Leu Leu  Tyr Tyr Thr 
    1235                 1240                 1245             


Gln Asn  Ile Ser Ala Thr Thr  Gly Ser Asn Asn Leu  Gly Tyr Ile 
    1250                 1255                 1260             


Glu Gln  His Arg Glu Glu Phe  Lys Glu Ile Phe Glu  Lys Ile Ile 
    1265                 1270                 1275             


Asp Phe  Ser Glu Lys Tyr Ile  Leu Lys Asn Lys Val  Asn Ser Asn 
    1280                 1285                 1290             


Leu Lys  Ser Ser Phe Asp Glu  Gln Phe Ala Val Ser  Asp Ser Ile 
    1295                 1300                 1305             


Leu Leu  Ser Asn Ser Phe Val  Ser Leu Leu Lys Tyr  Thr Ser Phe 
    1310                 1315                 1320             


Gly Ala  Ser Gly Gly Phe Thr  Phe Leu Asp Leu Asp  Val Lys Gln 
    1325                 1330                 1335             


Gly Arg  Leu Arg Tyr Gln Thr  Val Thr Glu Val Leu  Asp Ala Thr 
    1340                 1345                 1350             


Leu Ile  Tyr Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Thr Asp 
    1355                 1360                 1365             


Leu Ser  Gln Leu Gly Gly Asp  
    1370                 1375 


<210>  521
<211>  1368
<212>  PRT
<213>  Lactobacillus curvatus

<400>  521

Met Ser Arg Pro Tyr Asn Ile Gly Leu Asp Ile Gly Thr Ser Ser Ile 
1               5                   10                  15      


Gly Trp Ser Val Val Asp Asp Gln Ser Lys Leu Val Ser Val Arg Gly 
            20                  25                  30          


Lys Tyr Gly Tyr Gly Val Arg Leu Tyr Asp Glu Gly Gln Thr Ala Ala 
        35                  40                  45              


Glu Arg Arg Ser Phe Arg Thr Thr Arg Arg Arg Leu Lys Arg Arg Lys 
    50                  55                  60                  


Trp Arg Leu Gly Leu Leu Arg Glu Ile Phe Glu Pro Tyr Ile Thr Pro 
65                  70                  75                  80  


Val Asp Asp Thr Phe Phe Leu Arg Lys Lys Gln Ser Asn Leu Ser Pro 
                85                  90                  95      


Lys Asp Gln Arg Lys Leu Tyr Pro Gln Thr Ser Leu Phe Asn Asp Arg 
            100                 105                 110         


Thr Asp Arg Ala Phe Tyr Asp Asp Tyr Pro Thr Ile Tyr His Leu Arg 
        115                 120                 125             


Tyr Lys Leu Met Thr Glu Lys Arg Gln Phe Asp Ile Arg Glu Ile Tyr 
    130                 135                 140                 


Leu Ala Met His His Ile Val Lys Tyr Arg Gly His Phe Leu Asn Glu 
145                 150                 155                 160 


Ala Pro Val Ser Ser Phe Lys Ser Ser Glu Ile Asn Leu Val Ala His 
                165                 170                 175     


Phe Asp Arg Leu Asn Thr Ile Phe Ala Asp Leu Phe Ser Glu Ser Gly 
            180                 185                 190         


Phe Gln Leu Glu Thr Asp Lys Leu Ala Glu Val Lys Ala Leu Leu Leu 
        195                 200                 205             


Asp Asn His Gln Ser Ala Ser Asn Arg Gln Arg Gln Ala Leu Leu Leu 
    210                 215                 220                 


Ile Tyr Thr Pro Ser Thr Asn Lys Ala Val Glu Lys Gln Asn Lys Ala 
225                 230                 235                 240 


Ile Ala Thr Glu Leu Leu Lys Ala Ile Leu Gly Leu Lys Ala Lys Phe 
                245                 250                 255     


Asn Val Leu Thr Gly Ile Glu Ala Glu Asp Val Lys Thr Trp Thr Leu 
            260                 265                 270         


Thr Phe Asn Ala Glu Asn Phe Asp Glu Glu Met Val Lys Leu Glu Ser 
        275                 280                 285             


Ser Leu Asp Asp Asn Ala His Gln Ile Ile Glu Ser Leu Gln Glu Leu 
    290                 295                 300                 


Tyr Ser Gly Val Leu Leu Ala Gly Ile Val Pro Glu Asn Gln Ser Leu 
305                 310                 315                 320 


Ser Gln Ala Met Ile Thr Lys Tyr Asp Asp His Gln Lys His Leu Lys 
                325                 330                 335     


Met Leu Lys Ala Val Arg Glu Ala Leu Ala Pro Glu Asp Arg Gln Arg 
            340                 345                 350         


Leu Lys Gln Ala Tyr Asp Gln Tyr Val Asp Gly Gln Glu Asn Thr Lys 
        355                 360                 365             


Ala Tyr Ser Lys Glu Asp Phe Tyr Gly Asp Ile Thr Lys Ala Leu Lys 
    370                 375                 380                 


Asn Asn Pro Asp His Pro Ile Val Ser Glu Ile Lys Lys Leu Ile Glu 
385                 390                 395                 400 


Leu Asp Gln Phe Met Pro Lys Gln Arg Thr Lys Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Gln Gln Glu Leu Asp Arg Ile Ile Glu Asn Gln 
            420                 425                 430         


Gln Gln Tyr Tyr Pro Trp Leu Ala Glu Leu Asn Pro Asn Ser Lys Arg 
        435                 440                 445             


Gln Thr Val Ala Lys Tyr Lys Leu Asp Glu Leu Val Ala Phe Arg Val 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ile Thr Ala Glu Gln Gln Gln Gln Ser 
465                 470                 475                 480 


Ser Asp Ala Lys Phe Ala Trp Met Ile Arg Lys Ala Glu Gly Gln Ile 
                485                 490                 495     


Thr Pro Trp Asn Phe Asp Asp Lys Val Asp Arg Gln Ala Ser Ala Asn 
            500                 505                 510         


Glu Phe Ile Lys Arg Met Thr Thr Thr Asp Thr Tyr Leu Leu Ala Glu 
        515                 520                 525             


Asp Val Leu Pro Lys Gln Ser Leu Ile Tyr Gln Arg Phe Glu Val Leu 
    530                 535                 540                 


Asn Glu Leu Asn Gly Leu Lys Ile Asp Asp Gln Pro Ile Thr Thr Glu 
545                 550                 555                 560 


Leu Lys Gln Ala Ile Phe Thr Asp Leu Phe Met Gln Lys Thr Ser Val 
                565                 570                 575     


Thr Val Lys Asn Ile Gln Asp Tyr Leu Val Ser Glu Lys Arg Tyr Ala 
            580                 585                 590         


Ser Arg Pro Ala Ile Thr Gly Leu Ser Asp Glu Asn Lys Phe Asn Ser 
        595                 600                 605             


Arg Leu Ser Thr Tyr His Asp Leu Lys Thr Ile Val Gly Asp Ala Val 
    610                 615                 620                 


Asp Asp Val Asp Lys Gln Ala Asp Leu Glu Lys Cys Ile Glu Trp Ser 
625                 630                 635                 640 


Thr Ile Phe Glu Asp Gly Lys Ile Tyr Ser Ala Lys Leu Asn Glu Ile 
                645                 650                 655     


Asp Trp Leu Thr Asp Gln Gln Arg Val Gln Leu Ala Ala Lys Arg Tyr 
            660                 665                 670         


Arg Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Thr Gln Ile Val Asn 
        675                 680                 685             


Ala Asn Gly Gln Arg Ile Met Asp Leu Leu Trp Asp Thr Thr Asp Asn 
    690                 695                 700                 


Phe Met Arg Ile Val His Ser Glu Asp Phe Asp Lys Leu Ile Thr Glu 
705                 710                 715                 720 


Ala Asn Gln Met Met Leu Ala Glu Asn Asp Val Gln Asp Val Ile Asn 
                725                 730                 735     


Asp Leu Tyr Thr Ser Pro Gln Asn Lys Lys Ala Leu Arg Gln Ile Leu 
            740                 745                 750         


Leu Val Val Asn Asp Ile Gln Lys Ala Met Lys Gly Gln Ala Pro Glu 
        755                 760                 765             


Arg Ile Leu Ile Glu Phe Ala Arg Glu Asp Glu Val Asn Pro Arg Leu 
    770                 775                 780                 


Ser Val Gln Arg Lys Arg Gln Val Glu Gln Val Tyr Gln Asn Ile Ser 
785                 790                 795                 800 


Asn Glu Leu Leu Asn Asn Thr Glu Ile Arg Asn Glu Leu Lys Asp Leu 
                805                 810                 815     


Ser Asn Ser Ala Leu Ser Asn Thr Arg Leu Phe Leu Tyr Phe Met Gln 
            820                 825                 830         


Gly Gly Arg Asp Met Tyr Thr Gly Asp Ser Leu Asn Ile Asp Arg Leu 
        835                 840                 845             


Ser Thr Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe Ile Lys Asp 
    850                 855                 860                 


Asn Ser Leu Asp Asn Arg Val Leu Val Ser Gln Arg Met Asn Arg Ser 
865                 870                 875                 880 


Lys Ala Asp Gln Val Pro Thr Asp Phe Thr Ser Val Glu Leu Gly Gln 
                885                 890                 895     


Lys Met Gln Ile Gln Trp Glu Gln Met Leu Arg Ala Gly Leu Ile Thr 
            900                 905                 910         


Lys Lys Lys Tyr Asp Asn Leu Thr Leu Asn Pro Asp His Ile Ser Lys 
        915                 920                 925             


Tyr Ala Met Lys Gly Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln 
    930                 935                 940                 


Val Ile Lys Leu Ala Thr Asn Leu Leu Met Glu Gln Tyr Gly Glu Asp 
945                 950                 955                 960 


Asn Ile Glu Leu Ile Thr Val Lys Ser Gly Leu Thr His Gln Met Arg 
                965                 970                 975     


Thr Glu Phe Asp Phe Pro Lys Asn Arg Asn Leu Asn Asn His His His 
            980                 985                 990         


Ala Phe Asp Ala Tyr Leu Thr Ala  Phe Val Gly Leu Tyr  Leu Leu Lys 
        995                 1000                 1005             


Arg Tyr  Pro Lys Leu Lys Pro  Tyr Phe Val Tyr Gly  Glu Tyr Gln 
    1010                 1015                 1020             


Lys Ala  Ser Gln Gln Asp Lys  Trp Arg Asn Phe Asn  Phe Leu Asn 
    1025                 1030                 1035             


Gly Leu  Lys Lys Asp Glu Leu  Val Asp Glu Asn Thr  Glu Ala Val 
    1040                 1045                 1050             


Ile Trp  Asn Lys Glu Ser Gly  Leu Ala Tyr Leu Asn  Lys Ile Tyr 
    1055                 1060                 1065             


Gln Phe  Lys Lys Ile Leu Val  Thr Arg Glu Val His  Glu Asn Ser 
    1070                 1075                 1080             


Gly Ala  Leu Phe Asn Gln Thr  Leu Tyr Ala Ala Lys  Asp Asp Lys 
    1085                 1090                 1095             


Ala Ser  Gly Gln Gly Gly Lys  Gln Leu Ile Pro Ala  Lys Gln Asp 
    1100                 1105                 1110             


Arg Pro  Thr Ala Leu Tyr Gly  Gly Tyr Ser Gly Lys  Thr Val Ala 
    1115                 1120                 1125             


Tyr Met  Cys Ile Val Arg Ile  Lys Asn Lys Lys Gly  Asp Leu Tyr 
    1130                 1135                 1140             


Lys Val  Cys Gly Val Glu Thr  Ser Trp Leu Ala Gln  Leu Lys Gln 
    1145                 1150                 1155             


Leu Thr  Asp Glu Asp Ser Lys  Lys Ala Phe Leu Lys  Gln Lys Ile 
    1160                 1165                 1170             


Ser Pro  Gln Phe Thr Lys Val  Lys Lys Gln Lys Gly  Thr Ile Val 
    1175                 1180                 1185             


Lys Val  Val Glu Asp Phe Glu  Val Ile Ala Pro His  Ile Leu Ile 
    1190                 1195                 1200             


Asn Gln  Arg Phe Phe Asp Asn  Gly Gln Glu Leu Thr  Leu Gly Ser 
    1205                 1210                 1215             


Ala Thr  Tyr Lys His Asn Glu  Gln Glu Leu Ile Leu  Asp Lys Thr 
    1220                 1225                 1230             


Ala Val  Lys Leu Leu Asn Gly  Ala Leu Pro Leu Thr  Gln Ser Glu 
    1235                 1240                 1245             


Glu Leu  Ala Glu Gln Val Tyr  Asp Glu Ile Leu Asp  Gln Val Met 
    1250                 1255                 1260             


His Tyr  Phe Pro Leu Tyr Asp  Thr Asn Gln Phe Arg  Ala Lys Leu 
    1265                 1270                 1275             


Ser Ala  Gly Lys Ala Ala Phe  Met Lys Leu Pro Trp  Lys Ser Gln 
    1280                 1285                 1290             


Trp Asp  Gly Asn Lys Met Val  Gln Val Gly Gln Gln  Val Ile Leu 
    1295                 1300                 1305             


Asp Arg  Val Leu Ile Gly Leu  His Ala Asn Ala Ala  Val Ser Asp 
    1310                 1315                 1320             


Leu Gly  Val Leu Lys Ile Ser  Thr Pro Leu Gly Lys  Met Gln Gln 
    1325                 1330                 1335             


Pro Ser  Gly Ile Ser Leu Ser  Pro Asp Thr Gln Ile  Ile Tyr Gln 
    1340                 1345                 1350             


Ser Pro  Thr Gly Leu Phe Glu  Arg Arg Val Ala Leu  Arg Asp Leu 
    1355                 1360                 1365             


<210>  522
<211>  1356
<212>  PRT
<213>  Lactobacillus farciminis

<400>  522

Met Thr Lys Lys Glu Gln Pro Tyr Asn Ile Gly Leu Asp Ile Gly Thr 
1               5                   10                  15      


Gly Ser Val Gly Trp Ala Val Thr Asn Asp Asn Tyr Asp Leu Leu Asn 
            20                  25                  30          


Ile Lys Lys Lys Asn Leu Trp Gly Val Arg Leu Phe Glu Gly Ala Gln 
        35                  40                  45              


Thr Ala Lys Glu Thr Arg Leu Asn Arg Ser Thr Arg Arg Arg Tyr Arg 
    50                  55                  60                  


Arg Arg Lys Asn Arg Ile Asn Trp Leu Asn Glu Ile Phe Ser Glu Glu 
65                  70                  75                  80  


Leu Ala Asn Thr Asp Pro Ser Phe Leu Ile Arg Leu Gln Asn Ser Trp 
                85                  90                  95      


Val Ser Lys Lys Asp Pro Asp Arg Lys Arg Asp Lys Tyr Asn Leu Phe 
            100                 105                 110         


Ile Asp Asn Pro Tyr Thr Asp Lys Glu Tyr Tyr Arg Glu Phe Pro Thr 
        115                 120                 125             


Ile Phe His Leu Arg Lys Glu Leu Ile Ile Asn Lys Asn Lys Ala Asp 
    130                 135                 140                 


Ile Arg Leu Val Tyr Leu Ala Leu His Asn Ile Leu Lys Tyr Arg Gly 
145                 150                 155                 160 


Asn Phe Thr Tyr Glu His Gln Lys Phe Asn Ile Ser Thr Leu Asn Ser 
                165                 170                 175     


Asn Leu Ser Lys Glu Leu Ile Glu Leu Asn Gln Gln Leu Ile Lys Tyr 
            180                 185                 190         


Asp Ile Ser Phe Pro Asp Asn Cys Asp Trp Asn His Ile Ser Asp Ile 
        195                 200                 205             


Leu Ile Gly Arg Gly Asn Ala Thr Gln Lys Ser Ser Asn Ile Leu Asn 
    210                 215                 220                 


Asn Phe Thr Leu Asp Lys Glu Thr Lys Lys Leu Leu Lys Glu Val Ile 
225                 230                 235                 240 


Asn Leu Ile Leu Gly Asn Val Ala His Leu Asn Thr Ile Phe Lys Thr 
                245                 250                 255     


Ser Leu Thr Lys Asp Glu Glu Lys Leu Ser Phe Ser Gly Lys Asp Ile 
            260                 265                 270         


Glu Ser Lys Leu Asp Asp Leu Asp Ser Ile Leu Asp Asp Asp Gln Phe 
        275                 280                 285             


Thr Val Leu Asp Thr Ala Asn Arg Ile Tyr Ser Thr Ile Thr Leu Asn 
    290                 295                 300                 


Glu Ile Leu Asn Gly Glu Ser Tyr Phe Ser Met Ala Lys Val Asn Gln 
305                 310                 315                 320 


Tyr Glu Asn His Ala Ile Asp Leu Cys Lys Leu Arg Asp Met Trp His 
                325                 330                 335     


Thr Thr Lys Asn Glu Lys Ala Val Gly Leu Ser Arg Gln Ala Tyr Asp 
            340                 345                 350         


Asp Tyr Ile Asn Lys Pro Lys Tyr Gly Thr Lys Glu Leu Tyr Thr Ser 
        355                 360                 365             


Leu Lys Lys Phe Leu Lys Val Ala Leu Pro Thr Asn Leu Ala Lys Glu 
    370                 375                 380                 


Ala Glu Glu Lys Ile Ser Lys Gly Thr Tyr Leu Val Lys Pro Arg Asn 
385                 390                 395                 400 


Ser Glu Asn Gly Val Val Pro Tyr Gln Leu Asn Lys Ile Glu Met Glu 
                405                 410                 415     


Lys Ile Ile Asp Asn Gln Ser Gln Tyr Tyr Pro Phe Leu Lys Glu Asn 
            420                 425                 430         


Lys Glu Lys Leu Leu Ser Ile Leu Ser Phe Arg Ile Pro Tyr Tyr Val 
        435                 440                 445             


Gly Pro Leu Gln Ser Ser Glu Lys Asn Pro Phe Ala Trp Met Glu Arg 
    450                 455                 460                 


Lys Ser Asn Gly His Ala Arg Pro Trp Asn Phe Asp Glu Ile Val Asp 
465                 470                 475                 480 


Arg Glu Lys Ser Ser Asn Lys Phe Ile Arg Arg Met Thr Val Thr Asp 
                485                 490                 495     


Ser Tyr Leu Val Gly Glu Pro Val Leu Pro Lys Asn Ser Leu Ile Tyr 
            500                 505                 510         


Gln Arg Tyr Glu Val Leu Asn Glu Leu Asn Asn Ile Arg Ile Thr Glu 
        515                 520                 525             


Asn Leu Lys Thr Asn Pro Thr Gly Ser Arg Leu Thr Val Glu Thr Lys 
    530                 535                 540                 


Gln His Ile Tyr Asn Glu Leu Phe Lys Asn Tyr Lys Lys Ile Thr Val 
545                 550                 555                 560 


Lys Lys Leu Thr Lys Trp Leu Ile Ala Gln Gly Tyr Tyr Lys Asn Pro 
                565                 570                 575     


Ile Leu Ile Gly Leu Ser Gln Lys Asp Glu Phe Asn Ser Thr Leu Thr 
            580                 585                 590         


Thr Tyr Leu Asp Met Lys Lys Ile Phe Gly Ser Ser Phe Met Glu Asn 
        595                 600                 605             


Asn Lys Asn Tyr Asn Gln Ile Glu Glu Leu Ile Glu Trp Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Lys Gln Ile Leu Asn Glu Lys Leu His Ser Ser Asn Tyr 
625                 630                 635                 640 


Ser Tyr Thr Ser Asp Gln Ile Lys Lys Ile Ser Asn Met Arg Tyr Lys 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Lys Lys Ile Leu Thr Cys Ile Thr Thr Glu 
            660                 665                 670         


Thr Asn Thr Pro Lys Ser Leu Gln Leu Ser Asn Tyr Ser Val Leu Asp 
        675                 680                 685             


Leu Met Trp Thr Thr Asn Asn Asn Phe Ile Ser Ile Ile Ser Asn Asp 
    690                 695                 700                 


Lys Tyr Asp Phe Lys Asn Tyr Ile Glu Asn His Asn Leu Asn Lys Asn 
705                 710                 715                 720 


Glu Asp Gln Asn Ile Ser Asn Leu Val Asn Asp Ile His Val Ser Pro 
                725                 730                 735     


Ala Leu Lys Arg Gly Ile Thr Gln Ser Ile Lys Ile Val Gln Glu Ile 
            740                 745                 750         


Val Lys Phe Met Gly His Ala Pro Lys Tyr Ile Phe Ile Glu Val Thr 
        755                 760                 765             


Arg Glu Thr Lys Lys Ser Glu Ile Thr Thr Ser Arg Gly Lys Arg Ile 
    770                 775                 780                 


Gln Arg Leu Gln Ser Lys Leu Leu Asn Lys Ala Asn Gly Phe Lys Pro 
785                 790                 795                 800 


Gln Leu Arg Lys Tyr Leu Val Pro Asn Glu Lys Ile Gln Glu Glu Leu 
                805                 810                 815     


Lys Lys His Lys Asn Asp Leu Ser Ser Glu Arg Ile Met Leu Tyr Phe 
            820                 825                 830         


Leu Gln Asn Gly Lys Ser Leu Tyr Ser Glu Glu Ser Leu Asn Ile Asn 
        835                 840                 845             


Lys Leu Ser Asp Tyr Gln Val Asp His Ile Leu Pro Arg Thr Tyr Ile 
    850                 855                 860                 


Pro Asp Asp Ser Leu Glu Asn Lys Ala Leu Val Leu Ala Lys Glu Asn 
865                 870                 875                 880 


Gln Arg Lys Ala Asp Asp Leu Leu Leu Asn Ser Asn Val Ile Asp Lys 
                885                 890                 895     


Asn Leu Glu Arg Trp Thr Tyr Met Leu Asn Asn Asn Met Met Gly Leu 
            900                 905                 910         


Lys Lys Phe Lys Asn Leu Thr Arg Arg Val Ile Thr Asp Lys Asp Lys 
        915                 920                 925             


Leu Gly Phe Ile His Arg Gln Leu Val Gln Thr Ser Gln Met Val Lys 
    930                 935                 940                 


Gly Val Ala Asn Ile Leu Asn Ser Met Tyr Lys Asn Gln Gly Thr Thr 
945                 950                 955                 960 


Cys Ile Gln Ala Arg Ala Asn Leu Ser Thr Ala Phe Arg Lys Ala Leu 
                965                 970                 975     


Ser Asp Gln Asp Asp Arg Tyr His Phe Lys His Pro Glu Leu Val Lys 
            980                 985                 990         


Asn Arg Asn Ile Asn Asp Phe His  His Ala Gln Asp Ala  Tyr Leu Ala 
        995                 1000                 1005             


Ser Phe  Leu Gly Thr Tyr Arg  Leu Arg Arg Phe Pro  Thr Asp Glu 
    1010                 1015                 1020             


Met Leu  Leu Met Asn Gly Glu  Tyr Asn Lys Phe Tyr  Gly Gln Val 
    1025                 1030                 1035             


Lys Glu  Leu Tyr Ser Lys Lys  Lys Lys Leu Pro Asp  Ser Arg Lys 
    1040                 1045                 1050             


Asn Gly  Phe Ile Ile Ser Pro  Leu Val Asn Gly Thr  Thr Gln Tyr 
    1055                 1060                 1065             


Asp Arg  Asn Thr Gly Glu Ile  Ile Trp Asn Val Gly  Phe Arg Asp 
    1070                 1075                 1080             


Lys Ile  Leu Lys Ile Phe Asn  Tyr His Gln Cys Asn  Val Thr Arg 
    1085                 1090                 1095             


Lys Thr  Glu Ile Lys Thr Gly  Gln Phe Tyr Asp Gln  Thr Ile Tyr 
    1100                 1105                 1110             


Ser Pro  Lys Asn Pro Lys Tyr  Lys Lys Leu Ile Ala  Gln Lys Lys 
    1115                 1120                 1125             


Asp Met  Asp Pro Asn Ile Tyr  Gly Gly Phe Ser Gly  Asp Asn Lys 
    1130                 1135                 1140             


Ser Ser  Ile Thr Ile Val Lys  Ile Asp Asn Asn Lys  Ile Lys Pro 
    1145                 1150                 1155             


Val Ala  Ile Pro Ile Arg Leu  Ile Asn Asp Leu Lys  Asp Lys Lys 
    1160                 1165                 1170             


Thr Leu  Gln Asn Trp Leu Glu  Glu Asn Val Lys His  Lys Lys Ser 
    1175                 1180                 1185             


Ile Gln  Ile Ile Lys Asn Asn  Val Pro Ile Gly Gln  Ile Ile Tyr 
    1190                 1195                 1200             


Ser Lys  Lys Val Gly Leu Leu  Ser Leu Asn Ser Asp  Arg Glu Ile 
    1205                 1210                 1215             


Ala Asn  Arg Gln Gln Leu Ile  Leu Pro Pro Glu His  Ser Ala Leu 
    1220                 1225                 1230             


Leu Arg  Ile Leu Gln Ile Pro  Asp Glu Asp Pro Asp  Gln Ile Leu 
    1235                 1240                 1245             


Ala Phe  Tyr Asp Lys Asn Ile  Leu Val Glu Ile Leu  Gln Glu Leu 
    1250                 1255                 1260             


Ile Thr  Lys Met Lys Lys Phe  Tyr Pro Phe Tyr Lys  Asn Glu Gln 
    1265                 1270                 1275             


Glu Phe  Leu Ala Ser Asn Ile  Glu Asn Phe Asn Gln  Ala Thr Thr 
    1280                 1285                 1290             


Ser Glu  Lys Ile Asn Ser Leu  Glu Glu Leu Ile Thr  Leu Leu His 
    1295                 1300                 1305             


Ala Asn  Ser Thr Ser Ala His  Leu Ile Phe Asn Asn  Ile Glu Lys 
    1310                 1315                 1320             


Lys Ala  Phe Gly Arg Lys Thr  His Gly Leu Thr Leu  Asn Asp Thr 
    1325                 1330                 1335             


Asp Phe  Ile Tyr Gln Ser Val  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1340                 1345                 1350             


His Ile  Glu 
    1355     


<210>  523
<211>  1334
<212>  PRT
<213>  Listeria innocua

<400>  523

Met Lys Lys Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Ile Ala Gly Asp Ser Glu Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Ala Asp Arg Arg Met 
    50                  55                  60                  


Ala Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Gly Ile Phe Ala Glu Glu Met Ser Lys Thr Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Ser Asp Ser Phe Tyr Val Asp Asn Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Glu Tyr 
        115                 120                 125             


His Lys Asn Tyr Pro Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Gln Asn Thr Ser Val Asp Gly Ile Tyr Lys Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Ala Ser Gly Ile Glu Asp Gly Ser Leu Lys Lys Leu 
        195                 200                 205             


Glu Asp Asn Lys Asp Val Ala Lys Ile Leu Val Glu Lys Val Thr Arg 
    210                 215                 220                 


Lys Glu Lys Leu Glu Arg Ile Leu Lys Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Ala Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Pro Phe Asp Leu Ile Glu Lys Ser Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ser Leu Leu Ala Leu Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Ala Tyr Ser 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Ala Glu Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Thr His Glu Glu 
                325                 330                 335     


Asp Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys His 
            340                 345                 350         


Tyr Glu Glu Ile Phe Ser Asn Thr Glu Lys His Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Ala Asp Phe Tyr Lys Tyr Met Lys Met 
    370                 375                 380                 


Thr Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Lys Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Lys Glu Asn Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Leu Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Ile Asn Asp Gln Gly Lys Thr Ser Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Glu Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Met 
                565                 570                 575     


Ser His Val Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ser Ser Tyr Ser Thr Tyr His Asp Leu Leu Lys Val Gly Ile Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Val Asn Thr Glu Met Leu Glu Asn Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Met 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Thr Thr Ala 
705                 710                 715                 720 


Asp Lys Asp Ile Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Val Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Arg Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Arg Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Asp Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Asp Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Tyr 
    930                 935                 940                 


Glu Lys Asp Asp His Gly Asn Thr Met Lys Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Asp Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Asp  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Asp Thr Val Lys  Lys Val Met 
    1055                 1060                 1065             


Ser Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Thr  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Val  Ile Glu Tyr 
    1115                 1120                 1125             


Ala Lys  Gly Lys Asn Lys Leu  Val Phe Glu Lys Lys  Ile Ile Arg 
    1130                 1135                 1140             


Val Thr  Ile Met Glu Arg Lys  Ala Phe Glu Lys Asp  Glu Lys Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Gln Gly Tyr  Arg Gln Pro Lys Val  Leu Ala Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Glu Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ala Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Gln Val 
    1190                 1195                 1200             


Leu Pro  Asn His Leu Val Thr  Leu Leu His His Ala  Ala Asn Cys 
    1205                 1210                 1215             


Glu Val  Ser Asp Gly Lys Ser  Leu Asp Tyr Ile Glu  Ser Asn Arg 
    1220                 1225                 1230             


Glu Met  Phe Ala Glu Leu Leu  Ala His Val Ser Glu  Phe Ala Lys 
    1235                 1240                 1245             


Arg Tyr  Thr Leu Ala Glu Ala  Asn Leu Asn Lys Ile  Asn Gln Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Lys Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Thr Thr  Ile Glu Arg Lys Arg  Tyr Asn Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Asn Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210>  524
<211>  1334
<212>  PRT
<213>  Listeria innocua

<400>  524

Met Lys Lys Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Ile Ala Gly Asp Ser Glu Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Ala Asp Arg Arg Met 
    50                  55                  60                  


Ala Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Gly Ile Phe Ala Glu Glu Met Ser Lys Thr Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Ser Asp Ser Phe Tyr Val Asp Asn Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Glu Tyr 
        115                 120                 125             


His Lys Asn Tyr Pro Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Gln Asn Thr Ser Val Asp Gly Ile Tyr Lys Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Ala Ser Gly Ile Glu Asp Gly Ser Leu Lys Lys Leu 
        195                 200                 205             


Glu Asp Asn Lys Asp Val Ala Lys Ile Leu Val Glu Lys Val Thr Arg 
    210                 215                 220                 


Lys Glu Lys Leu Glu Arg Ile Leu Lys Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Ala Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Pro Phe Asp Leu Ile Glu Lys Ser Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ser Leu Leu Ala Leu Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Ala Tyr Ser 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Ala Glu Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Thr His Glu Glu 
                325                 330                 335     


Asp Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys His 
            340                 345                 350         


Tyr Glu Glu Ile Phe Ser Asn Thr Glu Lys His Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Ala Asp Phe Tyr Lys Tyr Met Lys Met 
    370                 375                 380                 


Thr Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Lys Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Lys Glu Asn Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Leu Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Ile Asn Asp Gln Gly Lys Thr Ser Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Glu Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Met 
                565                 570                 575     


Ser His Val Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ser Ser Tyr Ser Thr Tyr His Asp Leu Leu Lys Val Gly Ile Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Val Asn Thr Glu Met Leu Glu Asn Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Met 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Thr Thr Ala 
705                 710                 715                 720 


Asp Lys Asp Ile Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Val Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Arg Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Arg Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Asp Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Asp Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Tyr 
    930                 935                 940                 


Glu Lys Asp Asp His Gly Asn Thr Met Lys Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Asp Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Asp  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Asp Thr Val Lys  Lys Val Met 
    1055                 1060                 1065             


Ser Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Ser Arg Lys Thr  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Val  Ile Glu Tyr 
    1115                 1120                 1125             


Ala Lys  Gly Lys Asn Lys Leu  Val Phe Glu Lys Lys  Ile Ile Arg 
    1130                 1135                 1140             


Val Thr  Ile Met Glu Arg Lys  Ala Phe Glu Lys Asp  Glu Lys Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Gln Gly Tyr  Arg Gln Pro Lys Val  Leu Ala Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Glu Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ala Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Gln Val 
    1190                 1195                 1200             


Leu Pro  Asn His Leu Val Thr  Leu Leu His His Val  Ala Asn Cys 
    1205                 1210                 1215             


Glu Val  Ser Asp Gly Lys Ser  Leu Asp Tyr Ile Glu  Ser Asn Arg 
    1220                 1225                 1230             


Glu Met  Phe Ala Glu Leu Leu  Ala His Val Ser Glu  Phe Ala Lys 
    1235                 1240                 1245             


Arg Tyr  Thr Leu Ala Glu Ala  Asn Leu Asn Lys Ile  Asn Gln Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Lys Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Thr Thr  Ile Glu Arg Lys Arg  Tyr Asn Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Asn Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210>  525
<211>  1337
<212>  PRT
<213>  Unknown

<220>
<223>  Listeria innocua ATCC 33091

<400>  525

Met Lys Asn Met Lys Lys Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr 
1               5                   10                  15      


Asn Ser Val Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys 
            20                  25                  30          


Arg Lys Met Lys Ile Ala Gly Asp Ser Glu Lys Lys Gln Ile Lys Lys 
        35                  40                  45              


Asn Phe Trp Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Ala Asp 
    50                  55                  60                  


Arg Arg Met Ala Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn 
65                  70                  75                  80  


Arg Ile Ser Tyr Leu Gln Gly Ile Phe Ala Glu Glu Met Ser Lys Thr 
                85                  90                  95      


Asp Ala Asn Phe Phe Cys Arg Leu Ser Asp Ser Phe Tyr Val Asp Asn 
            100                 105                 110         


Glu Lys Arg Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu 
        115                 120                 125             


Val Glu Tyr His Lys Asn Tyr Pro Thr Ile Tyr His Leu Arg Glu Glu 
    130                 135                 140                 


Leu Val Asn Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala 
145                 150                 155                 160 


Leu Ala His Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala 
                165                 170                 175     


Leu Asp Thr Gln Asn Thr Ser Val Asp Gly Ile Tyr Lys Gln Phe Ile 
            180                 185                 190         


Gln Thr Tyr Asn Gln Val Phe Ala Ser Gly Ile Glu Asp Gly Ser Leu 
        195                 200                 205             


Lys Lys Leu Glu Asp Asn Lys Asp Val Ala Lys Ile Leu Val Glu Lys 
    210                 215                 220                 


Val Thr Arg Lys Glu Lys Leu Glu Arg Ile Leu Lys Leu Tyr Pro Gly 
225                 230                 235                 240 


Glu Lys Ser Ala Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly 
                245                 250                 255     


Ser Lys Gly Asn Phe Gln Lys Pro Phe Asp Leu Ile Glu Lys Ser Asp 
            260                 265                 270         


Ile Glu Cys Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ser Leu Leu 
        275                 280                 285             


Ala Leu Ile Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn 
    290                 295                 300                 


Ala Tyr Ser Ala Val Val Leu Ser Ser Ile Ile Thr Val Ala Glu Thr 
305                 310                 315                 320 


Glu Thr Asn Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Thr 
                325                 330                 335     


His Glu Glu Asp Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu 
            340                 345                 350         


Pro Lys His Tyr Glu Glu Ile Phe Ser Asn Thr Glu Lys His Gly Tyr 
        355                 360                 365             


Ala Gly Tyr Ile Asp Gly Lys Thr Lys Gln Ala Asp Phe Tyr Lys Tyr 
    370                 375                 380                 


Met Lys Met Thr Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala 
385                 390                 395                 400 


Lys Ile Glu Lys Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn 
                405                 410                 415     


Gly Ala Ile Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu 
            420                 425                 430         


His Gln Gln Ala Lys Tyr Tyr Pro Phe Leu Lys Glu Asn Tyr Asp Lys 
        435                 440                 445             


Ile Lys Ser Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu 
    450                 455                 460                 


Ala Asn Gly Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly 
465                 470                 475                 480 


Glu Ile Arg Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser 
                485                 490                 495     


Ala Val Asp Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro 
            500                 505                 510         


Lys Glu Asn Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Leu 
        515                 520                 525             


Val Tyr Asn Glu Leu Thr Lys Val Arg Tyr Ile Asn Asp Gln Gly Lys 
    530                 535                 540                 


Thr Ser Tyr Phe Ser Gly Gln Glu Lys Glu Gln Ile Phe Asn Asp Leu 
545                 550                 555                 560 


Phe Lys Gln Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu 
                565                 570                 575     


Arg Asn Met Ser His Val Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp 
            580                 585                 590         


Ser Phe Asn Ser Ser Tyr Ser Thr Tyr His Asp Leu Leu Lys Val Gly 
        595                 600                 605             


Ile Lys Gln Glu Ile Leu Asp Asn Pro Val Asn Thr Glu Met Leu Glu 
    610                 615                 620                 


Asn Ile Val Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys 
625                 630                 635                 640 


Glu Gln Leu Gln Gln Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys 
                645                 650                 655     


Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys 
            660                 665                 670         


Leu Leu Met Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp 
        675                 680                 685             


Tyr Leu Met Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile 
    690                 695                 700                 


Asn Asp Ser Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val 
705                 710                 715                 720 


Thr Thr Ala Asp Lys Asp Ile Gln Ser Ile Val Ala Asp Leu Ala Gly 
                725                 730                 735     


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp 
            740                 745                 750         


Glu Leu Val Ser Val Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu 
        755                 760                 765             


Met Ala Arg Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Arg 
    770                 775                 780                 


Pro Arg Tyr Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln 
785                 790                 795                 800 


Ile Leu Lys Glu His Pro Thr Asp Asn Gln Glu Leu Arg Asn Asn Arg 
                805                 810                 815     


Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln 
            820                 825                 830         


Asp Leu Asp Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val 
        835                 840                 845             


Pro Gln Ser Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr 
    850                 855                 860                 


Ser Ser Ala Gly Asn Arg Glu Lys Gly Asp Asp Val Pro Pro Leu Glu 
865                 870                 875                 880 


Ile Val Arg Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn 
                885                 890                 895     


Leu Met Ser Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly 
            900                 905                 910         


Gly Leu Thr Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val 
        915                 920                 925             


Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg 
    930                 935                 940                 


Phe Asn Tyr Glu Lys Asp Asp His Gly Asn Thr Met Lys Gln Val Arg 
945                 950                 955                 960 


Ile Val Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe 
                965                 970                 975     


Gln Leu Tyr Lys Val Arg Asp Val Asn Asp Tyr His His Ala His Asp 
            980                 985                 990         


Ala Tyr Leu Asn Gly Val Val Ala  Asn Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Gln Leu  Glu Pro Glu Phe Val  Tyr Gly Asp Tyr His  Gln Phe Asp 
    1010                 1015                 1020             


Trp Phe  Lys Ala Asn Lys Ala  Thr Ala Lys Lys Gln  Phe Tyr Thr 
    1025                 1030                 1035             


Asn Ile  Met Leu Phe Phe Ala  Gln Lys Asp Arg Ile  Ile Asp Glu 
    1040                 1045                 1050             


Asn Gly  Glu Ile Leu Trp Asp  Lys Lys Tyr Leu Asp  Thr Val Lys 
    1055                 1060                 1065             


Lys Val  Met Ser Tyr Arg Gln  Met Asn Ile Val Lys  Lys Thr Glu 
    1070                 1075                 1080             


Ile Gln  Lys Gly Glu Phe Ser  Lys Ala Thr Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Asn Ser  Ser Lys Leu Ile Ser  Arg Lys Thr Asn Trp  Asp Pro Met 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Leu Asp Ser  Pro Asn Met Ala Tyr  Ala Val Val 
    1115                 1120                 1125             


Ile Glu  Tyr Ala Lys Gly Lys  Asn Lys Leu Val Phe  Glu Lys Lys 
    1130                 1135                 1140             


Ile Ile  Arg Val Thr Ile Met  Glu Arg Lys Ala Phe  Glu Lys Asp 
    1145                 1150                 1155             


Glu Lys  Ala Phe Leu Glu Glu  Gln Gly Tyr Arg Gln  Pro Lys Val 
    1160                 1165                 1170             


Leu Ala  Lys Leu Pro Lys Tyr  Thr Leu Tyr Glu Cys  Glu Glu Gly 
    1175                 1180                 1185             


Arg Arg  Arg Met Leu Ala Ser  Ala Asn Glu Ala Gln  Lys Gly Asn 
    1190                 1195                 1200             


Gln Gln  Val Leu Pro Asn His  Leu Val Thr Leu Leu  His His Val 
    1205                 1210                 1215             


Ala Asn  Cys Glu Val Ser Asp  Gly Lys Ser Leu Asp  Tyr Ile Glu 
    1220                 1225                 1230             


Ser Asn  Arg Glu Met Phe Ala  Glu Leu Leu Ala His  Val Ser Glu 
    1235                 1240                 1245             


Phe Ala  Lys Arg Tyr Thr Leu  Ala Glu Ala Asn Leu  Asn Lys Ile 
    1250                 1255                 1260             


Asn Gln  Leu Phe Glu Gln Asn  Lys Glu Gly Asp Ile  Lys Ala Ile 
    1265                 1270                 1275             


Ala Gln  Ser Phe Val Asp Leu  Met Ala Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ala  Ser Phe Lys Phe Phe  Glu Thr Thr Ile Glu  Arg Lys Arg 
    1295                 1300                 1305             


Tyr Asn  Asn Leu Lys Glu Leu  Leu Asn Ser Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Ile  Thr Gly Leu Tyr Glu  Ser Arg Lys Arg Leu  Asp Asp 
    1325                 1330                 1335         


<210>  526
<211>  1103
<212>  PRT
<213>  Unknown

<220>
<223>  Listeria innocua FSL S4-378

<400>  526

Leu Lys Leu Tyr Pro Gly Glu Lys Ser Thr Gly Met Phe Ala Gln Phe 
1               5                   10                  15      


Ile Ser Leu Ile Val Gly Ser Lys Gly Asn Phe Gln Lys Pro Phe Asp 
            20                  25                  30          


Leu Ile Glu Lys Ser Asp Ile Glu Cys Ala Lys Asp Ser Tyr Glu Glu 
        35                  40                  45              


Asp Leu Glu Ser Leu Leu Ala Leu Ile Gly Asp Glu Tyr Ala Glu Leu 
    50                  55                  60                  


Phe Val Ala Ala Lys Asn Ala Tyr Ser Ala Val Val Leu Ser Ser Ile 
65                  70                  75                  80  


Ile Thr Val Ala Glu Thr Glu Thr Asn Ala Lys Leu Ser Ala Ser Met 
                85                  90                  95      


Ile Glu Arg Phe Asp Thr His Glu Glu Asp Leu Gly Glu Leu Lys Ala 
            100                 105                 110         


Phe Ile Lys Leu His Leu Pro Lys His Tyr Glu Glu Ile Phe Ser Asn 
        115                 120                 125             


Thr Glu Lys His Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Lys Gln 
    130                 135                 140                 


Ala Asp Phe Tyr Lys Tyr Met Lys Thr Thr Leu Glu Asn Ile Glu Gly 
145                 150                 155                 160 


Ala Asp Tyr Phe Ile Ala Lys Ile Glu Lys Glu Asn Phe Leu Arg Lys 
                165                 170                 175     


Gln Arg Thr Phe Asp Asn Gly Ala Ile Pro His Gln Leu His Leu Glu 
            180                 185                 190         


Glu Leu Glu Ala Ile Leu His Gln Gln Ala Lys Tyr Tyr Pro Phe Leu 
        195                 200                 205             


Lys Glu Asn Tyr Asp Lys Ile Lys Ser Leu Val Thr Phe Arg Ile Pro 
    210                 215                 220                 


Tyr Phe Val Gly Pro Leu Ala Asn Gly Gln Ser Glu Phe Ala Trp Leu 
225                 230                 235                 240 


Thr Arg Lys Ala Asp Gly Glu Ile Arg Pro Trp Asn Ile Glu Glu Lys 
                245                 250                 255     


Val Asp Phe Gly Lys Ser Ala Val Asp Phe Ile Glu Lys Met Thr Asn 
            260                 265                 270         


Lys Asp Thr Tyr Leu Pro Lys Glu Asn Val Leu Pro Lys His Ser Leu 
        275                 280                 285             


Cys Tyr Gln Lys Tyr Leu Val Tyr Asn Glu Leu Thr Lys Val Arg Tyr 
    290                 295                 300                 


Ile Asn Asp Gln Gly Lys Thr Ser Tyr Phe Ser Gly Gln Glu Lys Glu 
305                 310                 315                 320 


Gln Ile Phe Asn Asp Leu Phe Lys Gln Lys Arg Lys Val Lys Lys Lys 
                325                 330                 335     


Asp Leu Glu Leu Phe Leu Arg Asn Met Ser His Val Glu Ser Pro Thr 
            340                 345                 350         


Ile Glu Gly Leu Glu Asp Ser Phe Asn Ser Ser Tyr Ser Thr Tyr His 
        355                 360                 365             


Asp Leu Leu Lys Val Gly Ile Lys Gln Glu Ile Leu Asp Asn Pro Val 
    370                 375                 380                 


Asn Thr Glu Met Leu Glu Asn Ile Val Lys Ile Leu Thr Val Phe Glu 
385                 390                 395                 400 


Asp Lys Arg Met Ile Lys Glu Gln Leu Gln Gln Phe Ser Asp Val Leu 
                405                 410                 415     


Asp Gly Val Val Leu Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp 
            420                 425                 430         


Gly Arg Leu Ser Ala Lys Leu Leu Met Gly Ile Arg Asp Lys Gln Ser 
        435                 440                 445             


His Leu Thr Ile Leu Asp Tyr Leu Met Asn Asp Asp Gly Leu Asn Arg 
    450                 455                 460                 


Asn Leu Met Gln Leu Ile Asn Asp Ser Asn Leu Ser Phe Lys Ser Ile 
465                 470                 475                 480 


Ile Glu Lys Glu Gln Val Thr Thr Ala Asp Lys Asp Ile Gln Ser Ile 
                485                 490                 495     


Val Ala Asp Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
            500                 505                 510         


Ser Leu Lys Ile Val Asp Glu Leu Val Ser Val Met Gly Tyr Pro Pro 
        515                 520                 525             


Gln Thr Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Lys 
    530                 535                 540                 


Gly Lys Asn Asn Ser Arg Pro Arg Tyr Lys Ser Leu Glu Lys Ala Ile 
545                 550                 555                 560 


Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro Thr Asp Asn Gln 
                565                 570                 575     


Glu Leu Lys Asn Asn Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys 
            580                 585                 590         


Asp Met Tyr Thr Gly Gln Asp Leu Asp Ile His Asn Leu Ser Asn Tyr 
        595                 600                 605             


Asp Ile Asp His Ile Val Pro Gln Ser Phe Ile Thr Asp Asn Ser Ile 
    610                 615                 620                 


Asp Asn Leu Val Leu Thr Ser Ser Ala Gly Asn Arg Glu Lys Gly Asn 
625                 630                 635                 640 


Asp Val Pro Pro Leu Glu Ile Val Gln Lys Arg Lys Val Phe Trp Glu 
                645                 650                 655     


Lys Leu Tyr Gln Gly Asn Leu Met Ser Lys Arg Lys Phe Asp Tyr Leu 
            660                 665                 670         


Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Arg Phe 
        675                 680                 685             


Ile His Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala 
    690                 695                 700                 


Asn Ile Leu His Gln Arg Phe Asn Tyr Gly Lys Asp Asp His Gly Asn 
705                 710                 715                 720 


Thr Met Lys Gln Val Arg Ile Val Thr Leu Lys Ser Ala Leu Val Ser 
                725                 730                 735     


Gln Phe Arg Lys Gln Phe Gln Leu Tyr Lys Val Arg Gly Val Asn Asp 
            740                 745                 750         


Tyr His His Ala His Asp Ala Tyr Leu Asn Gly Val Val Ala Asn Thr 
        755                 760                 765             


Leu Leu Lys Val Tyr Pro Gln Leu Glu Pro Glu Phe Val Tyr Gly Asp 
    770                 775                 780                 


Tyr His Gln Phe Asp Trp Phe Lys Ala Asn Lys Ala Thr Ala Lys Lys 
785                 790                 795                 800 


Gln Phe Tyr Thr Asn Ile Met Leu Phe Phe Ala Gln Lys Asp Arg Ile 
                805                 810                 815     


Ile Asp Glu Asn Gly Glu Ile Leu Trp Asp Lys Lys Tyr Leu Asp Thr 
            820                 825                 830         


Val Lys Lys Val Met Ser Tyr Arg Gln Met Asn Ile Val Lys Lys Thr 
        835                 840                 845             


Glu Ile Gln Lys Gly Glu Phe Ser Lys Ala Thr Ile Lys Pro Lys Gly 
    850                 855                 860                 


Asn Ser Ser Lys Leu Ile Pro Arg Lys Thr Asn Trp Asp Pro Met Lys 
865                 870                 875                 880 


Tyr Gly Gly Leu Asp Ser Pro Asn Met Ala Tyr Ala Val Val Ile Glu 
                885                 890                 895     


Tyr Ala Lys Gly Lys Asn Lys Leu Val Phe Glu Lys Lys Ile Ile Arg 
            900                 905                 910         


Val Thr Ile Met Glu Arg Lys Ala Phe Glu Lys Asp Glu Lys Ala Phe 
        915                 920                 925             


Leu Glu Glu Gln Gly Tyr Arg Gln Pro Lys Val Leu Ala Lys Leu Pro 
    930                 935                 940                 


Lys Tyr Thr Leu Tyr Glu Cys Glu Glu Gly Arg Arg Arg Met Leu Ala 
945                 950                 955                 960 


Ser Ala Asn Glu Ala Gln Lys Gly Asn Gln Gln Val Leu Pro Asn His 
                965                 970                 975     


Leu Val Thr Leu Leu His His Ala Ala Asn Cys Glu Val Ser Asp Gly 
            980                 985                 990         


Lys Ser Leu Asp Tyr Ile Glu Ser  Asn Arg Glu Met Phe  Ala Glu Leu 
        995                 1000                 1005             


Leu Ala  His Val Ser Glu Phe  Ala Lys Arg Tyr Thr  Leu Ala Glu 
    1010                 1015                 1020             


Ala Asn  Leu Asn Lys Ile Asn  Gln Leu Phe Glu Gln  Asn Lys Glu 
    1025                 1030                 1035             


Gly Asp  Ile Lys Ala Ile Ala  Gln Ser Phe Val Asp  Leu Met Ala 
    1040                 1045                 1050             


Phe Asn  Ala Met Gly Ala Pro  Ala Ser Phe Lys Phe  Phe Glu Thr 
    1055                 1060                 1065             


Thr Ile  Glu Arg Lys Arg Tyr  Asn Asn Leu Lys Glu  Leu Leu Asn 
    1070                 1075                 1080             


Ser Thr  Ile Ile Tyr Gln Ser  Ile Thr Gly Leu Tyr  Glu Ser Arg 
    1085                 1090                 1095             


Lys Arg  Leu Asp Asp 
    1100             


<210>  527
<211>  1334
<212>  PRT
<213>  Listeria ivanovii

<400>  527

Met Arg Lys Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asn Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Ser Ala Glu Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Glu Val Ala Ala Gly Arg Arg Met 
    50                  55                  60                  


Asn Arg Thr Thr Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ala 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Ala Glu Met Ala Glu Val Asp Ala Asn 
                85                  90                  95      


Phe Phe Tyr Arg Leu Glu Asp Ser Phe Tyr Ile Glu Ser Glu Lys Arg 
            100                 105                 110         


His Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Glu Glu Tyr Lys Thr Ile Tyr His Leu Arg Glu Lys Leu Val Asn 
    130                 135                 140                 


Ser Ser Asp Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Met Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Glu Val Phe Lys Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Ile Phe Ala Ser Asp Ile Glu Glu Gly Ser Leu Thr Arg Leu 
        195                 200                 205             


Glu Glu Asn Lys Glu Val Ala Glu Ile Leu Ser Glu Lys Leu Thr Arg 
    210                 215                 220                 


Arg Glu Lys Leu Asp Lys Ile Leu Lys Leu Tyr Thr Gly Glu Lys Ser 
225                 230                 235                 240 


Thr Gly Met Phe Ala Arg Phe Ile Asn Leu Ile Ile Gly Ser Lys Gly 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Asp Leu Asp Glu Lys Ala Glu Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Thr Tyr Glu Glu Asp Leu Glu Ala Leu Leu Ala Lys Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Ile Phe Val Ala Ala Lys Ser Thr Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Asn Ile Ile Thr Val Thr Asp Thr Glu Thr Lys 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Lys His Ala Lys 
                325                 330                 335     


Asp Leu Lys Arg Leu Lys Ala Phe Phe Lys Met Gln Leu Pro Glu Lys 
            340                 345                 350         


Phe Asn Glu Val Phe Asn Asp Ile Glu Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Thr Gln Glu Lys Phe Tyr Lys Tyr Met Lys Lys 
    370                 375                 380                 


Met Leu Ala Asn Ile Asp Gly Ala Asp Tyr Phe Ile Asp Gln Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Thr Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Arg Lys Asp Tyr Glu Lys Ile Arg Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Ile Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Asp Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Ile Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Ile Arg Tyr Ile Asp Asp Gln Gly Lys Thr His His 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Gln Gln Ile Phe Asn Gly Leu Phe Lys Gln 
545                 550                 555                 560 


Gln Arg Lys Val Lys Lys Lys Asp Leu Glu Arg Phe Leu Tyr Thr Ile 
                565                 570                 575     


Asn His Ile Glu Ser Pro Thr Ile Glu Gly Val Glu Asp Ala Phe Asn 
            580                 585                 590         


Ser Ser Phe Ala Thr Tyr His Asp Leu Gln Lys Gly Gly Val Thr Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Ala Asp Met Leu Glu Glu Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Ser Phe Ser Asp Val Leu Asp Gly Thr Ile Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Thr 
            660                 665                 670         


Gly Ile Arg Asp Lys His Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Ala 
705                 710                 715                 720 


Asp Lys Gly Ile Gln Ser Ile Val Ala Glu Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Gly Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys Pro Arg Phe 
    770                 775                 780                 


Ile Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Cys Leu Lys Asn Asp Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Lys Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Ile Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Arg Val Leu Val Ser Ser Thr 
    850                 855                 860                 


Ala Asn Arg Glu Lys Gly Asp Asn Val Pro Leu Leu Glu Val Val Arg 
865                 870                 875                 880 


Lys Arg Lys Ala Phe Trp Glu Lys Leu Tyr Gln Ala Lys Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Asn Phe Ile Gln Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu Tyr Gln Arg Phe Asn Cys 
    930                 935                 940                 


Lys Gln Asp Glu Asn Gly Asn Glu Val Glu Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Arg Phe  Phe Ala Lys Glu Asn  Gln Ile Ile Asp Lys  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Asn Arg Tyr  Leu Asp Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Ser Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Asn Ala Thr  Val Asn Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Ser Arg Lys Ala  Asp Trp Asn Pro Ile  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Phe  Asp Gly Ser Asn Met  Ala Tyr Ser Ile Val  Ile Glu Tyr 
    1115                 1120                 1125             


Glu Lys  Arg Lys Lys Lys Thr  Val Ile Lys Lys Glu  Leu Ile Gln 
    1130                 1135                 1140             


Ile Asn  Ile Met Glu Arg Val  Ala Phe Glu Lys Asp  Gln Lys Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Lys Gly Tyr  Tyr Ser Pro Lys Val  Leu Thr Lys 
    1160                 1165                 1170             


Ile Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Asn Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Gly Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Met Val 
    1190                 1195                 1200             


Leu Pro  Asn His Leu Met Thr  Leu Leu Tyr His Ala  Lys Asn Cys 
    1205                 1210                 1215             


Glu Ala  Asn Asp Gly Glu Ser  Leu Ala Tyr Ile Glu  Met His Arg 
    1220                 1225                 1230             


Glu Met  Phe Ala Glu Leu Leu  Ala Tyr Ile Ser Glu  Phe Ala Lys 
    1235                 1240                 1245             


Arg Tyr  Thr Leu Ala Asn Asp  Arg Leu Glu Lys Ile  Asn Met Phe 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Lys Gly  Asp Ile Lys Val Ile  Ala Lys Ser 
    1265                 1270                 1275             


Phe Asp  Lys Leu Lys Val Phe  Asn Ala Phe Gly Ala  Pro Arg Asp 
    1280                 1285                 1290             


Phe Glu  Phe Phe Glu Thr Thr  Ile Lys Arg Lys Arg  Tyr Tyr Asn 
    1295                 1300                 1305             


Ile Lys  Glu Leu Leu Asn Ala  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ala Arg Lys  Arg Leu Glu Asp 
    1325                 1330                 


<210>  528
<211>  953
<212>  PRT
<213>  Unknown

<220>
<223>  Listeria ivanovii FSL F6-596

<400>  528

Met Lys Lys Met Leu Ala Asn Ile Asp Gly Ala Asp Tyr Phe Ile Asp 
1               5                   10                  15      


Gln Ile Glu Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn 
            20                  25                  30          


Gly Thr Ile Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu 
        35                  40                  45              


His Gln Gln Ala Lys Tyr Tyr Pro Phe Leu Arg Lys Asp Tyr Glu Lys 
    50                  55                  60                  


Ile Arg Ser Leu Val Thr Phe Arg Ile Pro Tyr Phe Ile Gly Pro Leu 
65                  70                  75                  80  


Ala Asn Gly Gln Ser Asp Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly 
                85                  90                  95      


Glu Ile Arg Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser 
            100                 105                 110         


Ala Ile Asp Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro 
        115                 120                 125             


Lys Glu Asn Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met 
    130                 135                 140                 


Val Tyr Asn Glu Leu Thr Lys Ile Arg Tyr Ile Asp Asp Gln Gly Lys 
145                 150                 155                 160 


Thr His His Phe Ser Gly Gln Glu Lys Gln Gln Ile Phe Asn Gly Leu 
                165                 170                 175     


Phe Lys Gln Gln Arg Lys Val Lys Lys Lys Asp Leu Glu Arg Phe Leu 
            180                 185                 190         


Tyr Thr Ile Asn His Ile Glu Ser Pro Thr Ile Glu Gly Val Glu Asp 
        195                 200                 205             


Ala Phe Asn Ser Ser Phe Ala Thr Tyr His Asp Leu Gln Lys Gly Gly 
    210                 215                 220                 


Val Thr Gln Glu Ile Leu Asp Asn Pro Leu Asn Ala Asp Met Leu Glu 
225                 230                 235                 240 


Glu Ile Val Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys 
                245                 250                 255     


Glu Gln Leu Gln Ser Phe Ser Asp Val Leu Asp Gly Thr Ile Leu Lys 
            260                 265                 270         


Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys 
        275                 280                 285             


Leu Leu Thr Gly Ile Arg Asp Lys His Ser His Leu Thr Ile Leu Asp 
    290                 295                 300                 


Tyr Leu Met Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile 
305                 310                 315                 320 


Asn Asp Ser Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val 
                325                 330                 335     


Ser Thr Ala Asp Lys Gly Ile Gln Ser Ile Val Ala Glu Leu Ala Gly 
            340                 345                 350         


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp 
        355                 360                 365             


Glu Leu Val Gly Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu 
    370                 375                 380                 


Met Ala Arg Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys 
385                 390                 395                 400 


Pro Arg Phe Ile Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln 
                405                 410                 415     


Ile Leu Lys Glu His Pro Thr Asp Asn Gln Cys Leu Lys Asn Asp Arg 
            420                 425                 430         


Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Lys 
        435                 440                 445             


Glu Leu Asp Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Ile 
    450                 455                 460                 


Pro Gln Ser Phe Ile Thr Asp Asn Ser Ile Asp Asn Arg Val Leu Val 
465                 470                 475                 480 


Ser Ser Thr Ala Asn Arg Glu Lys Gly Asp Asn Val Pro Leu Leu Glu 
                485                 490                 495     


Val Val Arg Lys Arg Lys Ala Phe Trp Glu Lys Leu Tyr Gln Ala Lys 
            500                 505                 510         


Leu Met Ser Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly 
        515                 520                 525             


Gly Leu Thr Glu Ala Asp Lys Ala Asn Phe Ile Gln Arg Gln Leu Val 
    530                 535                 540                 


Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Asn Ile Leu Tyr Gln Arg 
545                 550                 555                 560 


Phe Asn Cys Lys Gln Asp Glu Asn Gly Asn Glu Val Glu Gln Val Arg 
                565                 570                 575     


Ile Val Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Gln Phe 
            580                 585                 590         


Gln Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp 
        595                 600                 605             


Ala Tyr Leu Asn Gly Val Val Ala Asn Thr Leu Leu Lys Val Tyr Pro 
    610                 615                 620                 


Gln Leu Glu Pro Glu Phe Val Tyr Gly Asp Tyr His Gln Phe Asp Trp 
625                 630                 635                 640 


Phe Lys Ala Asn Lys Ala Thr Ala Lys Lys Gln Phe Tyr Thr Asn Ile 
                645                 650                 655     


Met Arg Phe Phe Ala Lys Glu Asn Gln Ile Ile Asp Lys Asn Gly Glu 
            660                 665                 670         


Ile Leu Trp Asp Asn Arg Tyr Leu Asp Thr Ile Lys Lys Val Leu Ser 
        675                 680                 685             


Tyr Arg Gln Met Asn Ile Val Lys Lys Thr Glu Ile Gln Lys Gly Glu 
    690                 695                 700                 


Phe Ser Asn Ala Thr Val Asn Pro Lys Gly Asn Ser Ser Lys Leu Ile 
705                 710                 715                 720 


Ser Arg Lys Ala Asp Trp Asn Pro Ile Lys Tyr Gly Gly Phe Asp Gly 
                725                 730                 735     


Ser Asn Met Ala Tyr Ser Ile Val Ile Glu Tyr Glu Lys Arg Lys Lys 
            740                 745                 750         


Lys Thr Val Ile Lys Lys Glu Leu Ile Gln Ile Asn Ile Met Glu Arg 
        755                 760                 765             


Val Ala Phe Glu Lys Asp Gln Lys Ala Phe Leu Glu Glu Lys Gly Tyr 
    770                 775                 780                 


Tyr Ser Pro Lys Val Leu Thr Lys Ile Pro Lys Tyr Thr Leu Tyr Glu 
785                 790                 795                 800 


Cys Glu Asn Gly Arg Arg Arg Met Leu Gly Ser Ala Asn Glu Ala Gln 
                805                 810                 815     


Lys Gly Asn Gln Met Val Leu Pro Asn His Leu Met Thr Leu Leu Tyr 
            820                 825                 830         


His Ala Lys Asn Cys Glu Ala Asn Asp Gly Glu Ser Leu Ala Tyr Ile 
        835                 840                 845             


Glu Met His Arg Glu Met Phe Ala Glu Leu Leu Ala Tyr Ile Ser Glu 
    850                 855                 860                 


Phe Ala Lys Arg Tyr Thr Leu Ala Asn Asp Arg Leu Glu Lys Ile Asn 
865                 870                 875                 880 


Met Phe Phe Glu Gln Asn Lys Lys Gly Asp Ile Lys Val Ile Ala Lys 
                885                 890                 895     


Ser Phe Asp Lys Leu Lys Val Phe Asn Ala Phe Gly Ala Pro Arg Asp 
            900                 905                 910         


Phe Glu Phe Phe Glu Thr Thr Ile Lys Arg Lys Arg Tyr Tyr Asn Ile 
        915                 920                 925             


Lys Glu Leu Leu Asn Ala Thr Ile Ile Tyr Gln Ser Ile Thr Gly Leu 
    930                 935                 940                 


Tyr Glu Ala Arg Lys Arg Leu Glu Asp 
945                 950             


<210>  529
<211>  1334
<212>  PRT
<213>  Listeria monocytogenes

<400>  529

Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asn Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Asp Gly Gln Thr Ala Val Asp Arg Arg Met 
    50                  55                  60                  


Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Val Glu Met Ala Asn Ile Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Asp Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Lys Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Glu Val Tyr Lys Gln Phe Ile Glu Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Met Ser Asn Ile Glu Glu Gly Ala Leu Ala Lys Val 
        195                 200                 205             


Glu Glu Asn Ile Glu Val Ala Asn Ile Leu Ala Gly Lys Phe Thr Arg 
    210                 215                 220                 


Arg Glu Lys Phe Glu Arg Ile Leu Gln Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Val Phe Asp Leu Ile Glu Lys Thr Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Thr Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Asp Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 
                325                 330                 335     


Asp Leu Val Glu Leu Lys Ala Phe Ile Lys Leu Asn Leu Pro Lys Gln 
            340                 345                 350         


Tyr Glu Glu Ile Phe Ser Asn Ala Ala Ile Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr Leu Lys Thr 
    370                 375                 380                 


Ile Leu Glu Asn Ile Glu Gly Ser Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Ile His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Lys Glu Asp Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Ile Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Arg Glu Lys Gln Gln Val Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 
                565                 570                 575     


Asn His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Met Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Pro Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Gly Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Glu Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Thr 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Glu Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Gly Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu Tyr Gln Arg Phe Asn Lys 
    930                 935                 940                 


Glu Thr Asp Asn His Gly Asn Thr Met Glu Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Gly Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Glu  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Glu Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Asp Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Glu  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Ile  Ile Glu His 
    1115                 1120                 1125             


Ala Lys  Gly Lys Lys Lys Ile  Val Ile Glu Lys Lys  Leu Ile Gln 
    1130                 1135                 1140             


Ile Asn  Ile Met Glu Arg Lys  Met Phe Glu Lys Asp  Glu Glu Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Lys Gly Tyr  Arg His Pro Lys Val  Leu Thr Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Lys Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ala Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Leu Val 
    1190                 1195                 1200             


Leu Ser  Asn His Leu Val Ser  Leu Leu Tyr His Ala  Lys Asn Cys 
    1205                 1210                 1215             


Glu Ala  Ser Asp Gly Lys Ser  Leu Lys Tyr Ile Glu  Ala His Arg 
    1220                 1225                 1230             


Glu Thr  Phe Ser Glu Leu Leu  Ala Gln Val Ser Glu  Phe Ala Thr 
    1235                 1240                 1245             


Arg Tyr  Thr Leu Ala Asp Ala  Asn Leu Ser Lys Ile  Asn Asn Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Lys Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Ala Thr  Ile Asp Arg Lys Arg  Tyr Thr Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Ser Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210>  530
<211>  1334
<212>  PRT
<213>  Listeria monocytogenes

<400>  530

Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Asp Gly Gln Thr Ala Val Asp Arg Arg Met 
    50                  55                  60                  


Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Val Glu Met Ala Asn Ile Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Glu Val Tyr Lys Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Met Ser Asn Ile Glu Glu Gly Ala Leu Ala Lys Val 
        195                 200                 205             


Glu Glu Asn Thr Glu Val Ala Ser Ile Leu Ala Gly Lys Phe Thr Arg 
    210                 215                 220                 


Arg Glu Lys Phe Glu Arg Ile Leu Arg Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Asn Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Val Phe Asn Leu Val Glu Lys Thr Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ala Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Ala Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 
                325                 330                 335     


Glu Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys Gln 
            340                 345                 350         


Tyr Gln Glu Ile Phe Asn Asn Ala Glu Ile Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr Leu Lys Thr 
    370                 375                 380                 


Thr Leu Glu Asn Val Glu Gly Ala Asp Tyr Phe Ile Thr Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Gly Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Asp Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Ile Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Arg Glu Lys Gln Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 
                565                 570                 575     


Asn His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Leu Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Ile Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Glu Gln Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Thr 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Asp Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Ile Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Gly Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Lys 
    930                 935                 940                 


Glu Thr Asp Asn His Gly Asn Thr Met Glu Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Glu  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Glu Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Asp Tyr  Arg Gln Ile Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Glu  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Ile  Ile Glu His 
    1115                 1120                 1125             


Ala Lys  Gly Lys Lys Lys Ile  Val Ile Glu Lys Lys  Leu Ile Gln 
    1130                 1135                 1140             


Ile Asn  Ile Met Glu Arg Lys  Met Phe Glu Lys Asp  Glu Glu Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Lys Gly Tyr  His Gln Pro Lys Val  Leu Thr Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Lys Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ser Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Leu Val 
    1190                 1195                 1200             


Leu Ser  Asn His Leu Val Ser  Leu Leu Tyr His Ala  Lys Asn Cys 
    1205                 1210                 1215             


Glu Ala  Ser Asp Gly Lys Ser  Leu Lys Tyr Ile Glu  Ala His Arg 
    1220                 1225                 1230             


Glu Thr  Phe Ser Glu Leu Leu  Ala Gln Val Ser Glu  Phe Ala Thr 
    1235                 1240                 1245             


Lys Tyr  Thr Leu Ala Asp Ala  Asn Leu Ser Lys Ile  Asn Asn Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Lys Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Ala Thr  Ile Asp Arg Lys Arg  Tyr Thr Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Ser Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210>  531
<211>  1334
<212>  PRT
<213>  Listeria monocytogenes

<400>  531

Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Asp Gly Gln Thr Ala Val Asp Arg Arg Met 
    50                  55                  60                  


Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Val Glu Met Ala Asn Ile Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Glu Val Tyr Lys Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Met Ser Asn Ile Glu Glu Gly Ala Leu Ala Lys Val 
        195                 200                 205             


Glu Glu Asn Thr Glu Val Ala Ser Ile Leu Ala Gly Lys Phe Thr Arg 
    210                 215                 220                 


Arg Glu Lys Phe Glu Arg Ile Leu Arg Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Asn Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Val Phe Asn Leu Val Glu Lys Thr Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ala Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Ala Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 
                325                 330                 335     


Glu Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys Gln 
            340                 345                 350         


Tyr Gln Glu Ile Phe Asn Asn Ala Glu Ile Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr Leu Lys Thr 
    370                 375                 380                 


Thr Leu Glu Asn Val Glu Gly Ala Asp Tyr Phe Ile Thr Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Gly Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Asp Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Ile Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Arg Glu Lys Gln Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 
                565                 570                 575     


Asn His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Leu Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Ile Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Glu Gln Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Thr 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Asp Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Ile Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Gly Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Lys 
    930                 935                 940                 


Glu Thr Asp Asn His Gly Asn Thr Met Glu Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Glu  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Glu Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Asp Tyr  Arg Gln Ile Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Glu  Asn Trp Asp Pro Val  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Ile  Ile Glu His 
    1115                 1120                 1125             


Ala Lys  Gly Lys Lys Lys Ile  Val Ile Glu Lys Lys  Leu Ile Gln 
    1130                 1135                 1140             


Ile Asn  Ile Met Glu Arg Lys  Met Phe Glu Lys Asp  Glu Glu Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Lys Gly Tyr  His Gln Pro Lys Val  Leu Thr Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Lys Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ser Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Leu Val 
    1190                 1195                 1200             


Leu Ser  Asn His Leu Val Ser  Leu Leu Tyr His Ala  Lys Asn Cys 
    1205                 1210                 1215             


Glu Ala  Ser Asp Gly Lys Ser  Leu Lys Tyr Ile Glu  Ala His Arg 
    1220                 1225                 1230             


Glu Thr  Phe Ser Glu Leu Leu  Ala Gln Val Ser Glu  Phe Ala Thr 
    1235                 1240                 1245             


Lys Tyr  Thr Leu Ala Asp Ala  Asn Leu Ser Lys Ile  Asn Asn Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Lys Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Ala Thr  Ile Asp Arg Lys Arg  Tyr Thr Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Ser Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210>  532
<211>  1334
<212>  PRT
<213>  Listeria monocytogenes

<400>  532

Met Lys Lys Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Ile Ser Gly Asp Ser Glu Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Lys Gly Glu Thr Ala Ala Lys Arg Arg Met 
    50                  55                  60                  


Ser Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Ile Gln Met Asn Glu Val Asp Asp Asn 
                85                  90                  95      


Phe Phe Asn Arg Leu Lys Glu Ser Phe Tyr Ala Glu Ser Asp Lys Lys 
            100                 105                 110         


Tyr Asn Arg His Pro Phe Phe Gly Thr Val Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


Tyr Lys Asp Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ile Asp 
    130                 135                 140                 


Ser Gln Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Ile Asp Glu Met Phe Lys Gln Phe Leu Gln Ile Tyr 
            180                 185                 190         


Asn Gln Val Phe Ala Asn Asp Ile Glu Glu Ala Ser Leu Lys Lys Thr 
        195                 200                 205             


Glu Lys Asn Gln Glu Val Ala Gln Ile Leu Ala Glu Lys Phe Thr Arg 
    210                 215                 220                 


Lys Asp Lys Leu Asp Lys Ile Leu Ser Leu Tyr Pro Gly Glu Lys Thr 
225                 230                 235                 240 


Thr Gly Val Phe Ala Gln Phe Val Asn Ile Ile Val Gly Ser Thr Gly 
                245                 250                 255     


Lys Phe Lys Lys His Phe Asn Leu His Glu Lys Lys Asp Ile Asn Cys 
            260                 265                 270         


Ala Glu Asp Thr Tyr Asp Thr Asp Leu Glu Ser Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Phe Ala Glu Val Phe Val Ala Ala Lys Asn Ala Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Asn Ile Ile Thr Val Thr Asp Ser Thr Thr Arg 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Leu Ile Glu Arg Phe Glu Asn His Lys Glu 
                325                 330                 335     


Asp Leu Lys Lys Met Lys Arg Phe Val Arg Thr Tyr Leu Pro Glu Lys 
            340                 345                 350         


Tyr Asp Glu Ile Phe Asp Asp Thr Glu Lys His Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ser Gly Lys Thr Lys Gln Ala Asp Phe Tyr Lys Tyr Met Lys Ala 
    370                 375                 380                 


Thr Leu Glu Lys Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Asp Tyr Glu Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Lys Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Gln Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 
                565                 570                 575     


Asn Gln Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Met Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Thr Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Thr 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Glu Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Val Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Asn Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Val Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Asp Asn Val Pro Pro Leu Glu Ile Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ile Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Tyr 
    930                 935                 940                 


Lys Thr Asp Gly Asn Lys Asp Thr Met Glu Thr Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Phe Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Gly  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Asp  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Arg Tyr  Leu Glu Thr Val Lys  Lys Val Leu 
    1055                 1060                 1065             


Gly Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Asn Val Thr  Pro Asn Pro Lys Gly  Lys Ser Asn 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Lys  Asp Trp Asp Pro Ile  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Phe  Asp Gly Ser Lys Met  Ala Tyr Ala Ile Ile  Ile Glu Tyr 
    1115                 1120                 1125             


Glu Lys  Gln Lys Arg Lys Val  Arg Ile Glu Lys Lys  Leu Ile Gln 
    1130                 1135                 1140             


Ile Asn  Ile Met Glu Arg Glu  Ala Phe Glu Lys Asp  Glu Lys Thr 
    1145                 1150                 1155             


Phe Leu  Glu Glu Lys Gly Tyr  His Gln Pro Lys Val  Leu Ile Lys 
    1160                 1165                 1170             


Val Pro  Lys Tyr Thr Leu Tyr  Glu Cys Lys Asn Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Gly Ser Ala Asn Glu  Ala His Lys Gly Asn  Gln Met Leu 
    1190                 1195                 1200             


Leu Pro  Asn His Leu Met Ala  Leu Leu Tyr His Ala  Glu Lys Tyr 
    1205                 1210                 1215             


Glu Ala  Ile Asp Gly Glu Ser  Leu Ala Tyr Ile Glu  Val His Arg 
    1220                 1225                 1230             


Ala Leu  Phe Asp Glu Leu Leu  Ala Tyr Ile Ser Glu  Phe Ala Arg 
    1235                 1240                 1245             


Lys Tyr  Thr Leu Ser Asn Asp  Arg Leu Asp Glu Ile  Asn Met Leu 
    1250                 1255                 1260             


Tyr Glu  Arg Asn Lys Asp Gly  Asp Val Lys Ser Ile  Ala Glu Ser 
    1265                 1270                 1275             


Phe Val  Ser Leu Lys Lys Phe  Asn Ala Phe Gly Val  His Gln Asp 
    1280                 1285                 1290             


Phe Ser  Phe Phe Gly Thr Lys  Ile Glu Arg Lys Arg  Asp Arg Lys 
    1295                 1300                 1305             


Leu Asn  Glu Leu Leu Asn Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asn 
    1325                 1330                 


<210>  533
<211>  1334
<212>  PRT
<213>  Listeria monocytogenes

<400>  533

Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Glu Thr Ala Ala Asp Arg Arg Met 
    50                  55                  60                  


Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Leu Glu Met Ala Asn Ile Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Gly Val Tyr Lys Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Ile Ser Asn Ile Glu Glu Gly Thr Leu Ala Lys Met 
        195                 200                 205             


Glu Glu Asn Thr Thr Val Ala Asp Ile Leu Ala Gly Lys Phe Thr Arg 
    210                 215                 220                 


Lys Glu Lys Leu Glu Arg Ile Leu Gln Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Val Phe Asp Leu Val Glu Lys Thr Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ala Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Asp Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 
                325                 330                 335     


Asp Leu Ser Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys Gln 
            340                 345                 350         


Tyr Glu Glu Ile Phe Ser Asn Val Ala Ile Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr Leu Lys Thr 
    370                 375                 380                 


Leu Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Lys Glu Ala Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Asp Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Tyr Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Gln Gln Ile Phe Asn Asp Tyr Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Ser Lys Lys Asp Leu Glu Gln Phe Leu Arg Asn Met 
                565                 570                 575     


Ser His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ser Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Ile Lys Gln 
        595                 600                 605             


Glu Val Leu Glu Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Ala Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Thr 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Val Lys Gly Lys Asn Asn Ser Arg Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Arg Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Asp Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Phe Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Thr Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Asn 
    930                 935                 940                 


Glu Thr Asp Asn His Gly Asn Asn Met Glu Gln Val Arg Ile Val Met 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Glu  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Glu Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Asp Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Glu  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Ile  Ile Glu His 
    1115                 1120                 1125             


Ala Lys  Gly Lys Lys Lys Val  Val Phe Glu Lys Lys  Ile Ile Arg 
    1130                 1135                 1140             


Ile Thr  Ile Met Glu Arg Lys  Ala Phe Glu Lys Asp  Glu Lys Ser 
    1145                 1150                 1155             


Phe Leu  Glu Lys Gln Gly Tyr  Arg Gln Pro Lys Val  Leu Thr Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Asn Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ala Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Gln Val 
    1190                 1195                 1200             


Leu Lys  Gly Gln Leu Ile Thr  Leu Leu His His Ala  Lys Asn Cys 
    1205                 1210                 1215             


Glu Ala  Ser Asp Gly Lys Ser  Leu Asp Tyr Ile Glu  Ser Asn Arg 
    1220                 1225                 1230             


Glu Met  Phe Gly Glu Leu Leu  Ala His Val Ser Glu  Phe Ala Lys 
    1235                 1240                 1245             


Arg Tyr  Thr Leu Ala Asp Ala  Asn Leu Ser Lys Ile  Asn Gln Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Asp Asn  Asp Ile Lys Val Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asn Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Ala Thr  Ile Glu Arg Lys Arg  Tyr Thr Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Ser Ala  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ala Arg Lys  Arg Leu Asp Gly 
    1325                 1330                 


<210>  534
<211>  1334
<212>  PRT
<213>  Listeria monocytogenes

<400>  534

Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asn Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Asp Gly Gln Thr Ala Val Asp Arg Arg Met 
    50                  55                  60                  


Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Val Glu Met Ala Asn Ile Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Gly Val Tyr Glu Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Met Ser Asn Ile Glu Glu Gly Thr Leu Ala Lys Val 
        195                 200                 205             


Glu Glu Asn Ile Glu Val Ala Asn Ile Leu Ala Gly Lys Phe Thr Arg 
    210                 215                 220                 


Arg Glu Lys Phe Glu Arg Ile Leu Gln Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Val Phe Asp Leu Ile Glu Lys Thr Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ala Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Ala Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 
                325                 330                 335     


Asp Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys Gln 
            340                 345                 350         


Tyr Gln Glu Ile Phe Asn Asn Ala Ala Ile Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr Leu Lys Thr 
    370                 375                 380                 


Ile Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Ile His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Asp Tyr Glu Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Lys Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Gln Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 
                565                 570                 575     


Asn His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Met Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Pro Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Gly Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Glu Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Thr 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Lys Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Gly Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Asp Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Asn 
    930                 935                 940                 


Glu Thr Asp Asn His Gly Asn Thr Met Glu Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Gly Gln Lys Glu  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Glu Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Asp Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Glu  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Ile  Ile Glu His 
    1115                 1120                 1125             


Ala Lys  Gly Lys Lys Lys Leu  Ile Phe Glu Lys Lys  Ile Ile Arg 
    1130                 1135                 1140             


Ile Thr  Ile Met Glu Arg Lys  Met Phe Glu Lys Asp  Glu Glu Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Lys Gly Tyr  Arg His Pro Lys Val  Leu Thr Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Lys Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ala Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Leu Val 
    1190                 1195                 1200             


Leu Ser  Asn His Leu Val Ser  Leu Leu Tyr His Ala  Lys Asn Cys 
    1205                 1210                 1215             


Glu Ala  Ser Asp Gly Lys Ser  Leu Lys Tyr Ile Glu  Ala His Arg 
    1220                 1225                 1230             


Glu Thr  Phe Ser Glu Leu Leu  Ala Gln Val Ser Glu  Phe Ala Thr 
    1235                 1240                 1245             


Arg Tyr  Thr Leu Ala Asp Ala  Asn Leu Ser Lys Ile  Asn Asn Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Gln Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Ala Thr  Ile Asp Arg Lys Arg  Tyr Thr Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Ser Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210>  535
<211>  1334
<212>  PRT
<213>  Listeria monocytogenes

<400>  535

Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asn Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Asp Gly Gln Thr Ala Val Asp Arg Arg Met 
    50                  55                  60                  


Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Val Glu Met Ala Asn Ile Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Gly Val Tyr Glu Gln Phe Ile Leu Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Met Ser Asn Ile Glu Glu Gly Thr Leu Ala Lys Val 
        195                 200                 205             


Glu Glu Asn Ile Glu Val Ala Asn Ile Leu Ala Gly Lys Phe Thr Arg 
    210                 215                 220                 


Arg Glu Lys Phe Glu Arg Ile Leu Gln Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Val Phe Asp Leu Ile Glu Lys Thr Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Thr Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Asp Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 
                325                 330                 335     


Asp Leu Val Glu Leu Lys Ala Phe Ile Lys Leu Asn Leu Pro Lys Gln 
            340                 345                 350         


Tyr Glu Glu Ile Phe Ser Asn Ala Ala Ile Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr Leu Lys Thr 
    370                 375                 380                 


Thr Leu Glu Asn Val Glu Gly Ala Asp Tyr Phe Ile Thr Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Asp Tyr Glu Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Lys Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Ile Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Gln Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 
                565                 570                 575     


Asn His Val Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ala Ser Tyr Ala Thr Tyr His Asp Leu Met Lys Val Gly Ile Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Thr Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Ala 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Val Val Glu Glu Leu Val 
            740                 745                 750         


Ser Val Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Asn Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Asp Asn Val Pro Pro Leu Glu Ile Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ile Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Tyr 
    930                 935                 940                 


Lys Thr Asp Asp Asn Glu Asp Thr Met Glu Pro Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Glu  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Glu Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Asn Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Asn Gln Asn  Pro Lys Pro Arg Gly  Asp Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Lys Lys Thr  Asn Leu Asn Pro Ile  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Phe  Glu Gly Ser Asn Met  Ala Tyr Ala Ile Ile  Ile Glu His 
    1115                 1120                 1125             


Glu Lys  Arg Lys Lys Lys Val  Thr Ile Glu Lys Lys  Leu Ile Gln 
    1130                 1135                 1140             


Ile Asn  Ile Met Glu Arg Lys  Ala Phe Glu Lys Asp  Glu Lys Val 
    1145                 1150                 1155             


Phe Leu  Glu Gly Lys Gly Tyr  His Gln Pro Lys Val  Leu Thr Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Ala Leu Tyr  Glu Cys Glu Asn Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Gly Ser Ala Asn Glu  Val His Lys Gly Asn  Gln Met Leu 
    1190                 1195                 1200             


Leu Pro  Asn His Leu Met Thr  Leu Leu Tyr His Ala  Glu Lys Arg 
    1205                 1210                 1215             


Glu Ala  Ile Asp Gly Glu Ser  Leu Ala Tyr Ile Glu  Ala His Lys 
    1220                 1225                 1230             


Ala Val  Phe Gly Glu Leu Leu  Ala His Ile Ser Glu  Phe Ala Arg 
    1235                 1240                 1245             


Lys Tyr  Thr Leu Ala Asn Asp  Lys Leu Asp Glu Ile  Asn Met Leu 
    1250                 1255                 1260             


Tyr Glu  Arg Asn Lys Asp Gly  Asp Val Lys Ser Ile  Ala Glu Ser 
    1265                 1270                 1275             


Phe Val  Ser Leu Lys Lys Phe  Asn Ala Phe Gly Val  His Lys Asp 
    1280                 1285                 1290             


Phe Asn  Phe Phe Gly Thr Thr  Ile Lys Arg Lys Arg  Asp Arg Lys 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Asn Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Ser 
    1325                 1330                 


<210>  536
<211>  1334
<212>  PRT
<213>  Listeria monocytogenes

<400>  536

Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Asp Gly Gln Thr Ala Val Asp Arg Arg Met 
    50                  55                  60                  


Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Val Glu Met Ala Asn Ile Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Gly Val Tyr Glu Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Met Ser Asn Ile Glu Glu Gly Thr Leu Ala Lys Val 
        195                 200                 205             


Glu Glu Asn Ile Glu Val Ala Asn Ile Leu Ala Gly Lys Phe Thr Arg 
    210                 215                 220                 


Arg Glu Lys Phe Glu Arg Ile Leu Gln Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Val Phe Asp Leu Ile Glu Lys Thr Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Thr Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Asn Asp Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 
                325                 330                 335     


Asp Leu Val Glu Leu Lys Ala Phe Ile Lys Leu Asn Leu Pro Lys Gln 
            340                 345                 350         


Tyr Glu Glu Ile Phe Ser Asn Ala Ala Ile Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr Leu Lys Thr 
    370                 375                 380                 


Ile Leu Glu Asn Ile Glu Gly Ser Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Ile His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Thr Phe Leu Lys Glu Asp Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Gln Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 
                565                 570                 575     


Asn Gln Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Met Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Glu Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Thr 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Glu Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Gly Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Lys 
    930                 935                 940                 


Glu Thr Asp Asn His Gly Asn Thr Met Glu Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Glu  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Glu Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Asp Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Glu  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Ile  Ile Glu His 
    1115                 1120                 1125             


Ala Lys  Gly Lys Lys Arg Ile  Val Ile Glu Lys Lys  Leu Ile Gln 
    1130                 1135                 1140             


Ile Asn  Ile Met Glu Arg Lys  Met Phe Glu Lys Asp  Glu Glu Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Lys Gly Tyr  Arg His Pro Lys Val  Leu Thr Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Lys Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ala Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Leu Val 
    1190                 1195                 1200             


Leu Ser  Asn His Leu Val Ser  Leu Leu Tyr His Ala  Lys Asn Cys 
    1205                 1210                 1215             


Glu Ala  Ser Asp Gly Lys Ser  Leu Lys Tyr Ile Glu  Ala His Arg 
    1220                 1225                 1230             


Glu Thr  Phe Ser Glu Leu Leu  Ala Gln Val Ser Glu  Phe Ala Thr 
    1235                 1240                 1245             


Arg Tyr  Thr Leu Ala Asp Ala  Asn Leu Ser Lys Ile  Asn Asn Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Lys Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Ala Thr  Ile Asp Arg Lys Arg  Tyr Thr Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Ser Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210>  537
<211>  1334
<212>  PRT
<213>  Listeria monocytogenes

<400>  537

Met Lys Lys Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Ile Ser Gly Asp Ser Glu Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Lys Gly Glu Thr Ala Ala Lys Arg Arg Met 
    50                  55                  60                  


Ser Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Ile Gln Met Asn Glu Val Asp Asp Asn 
                85                  90                  95      


Phe Phe Asn Arg Leu Lys Glu Ser Phe Tyr Ala Glu Ser Asp Lys Lys 
            100                 105                 110         


Tyr Asn Arg His Pro Phe Phe Gly Thr Val Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


Tyr Lys Asp Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ile Asp 
    130                 135                 140                 


Ser Gln Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Ile Asp Glu Met Phe Lys Gln Phe Leu Gln Ile Tyr 
            180                 185                 190         


Asn Gln Val Phe Ala Asn Asp Ile Glu Glu Ala Ser Leu Lys Lys Thr 
        195                 200                 205             


Glu Lys Asn Gln Glu Val Ala Gln Ile Leu Ala Glu Lys Phe Thr Arg 
    210                 215                 220                 


Lys Asp Lys Leu Asp Lys Ile Leu Ser Leu Tyr Pro Gly Glu Lys Thr 
225                 230                 235                 240 


Thr Gly Val Phe Ala Gln Phe Val Asn Ile Ile Val Gly Ser Thr Gly 
                245                 250                 255     


Lys Phe Lys Lys His Phe Asn Leu His Glu Lys Lys Asp Ile Asn Cys 
            260                 265                 270         


Ala Glu Asp Thr Tyr Asp Thr Asp Leu Glu Ser Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Phe Ala Glu Val Phe Val Ala Ala Lys Asn Ala Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Asn Ile Ile Thr Val Thr Asp Ser Thr Thr Arg 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Leu Ile Glu Arg Phe Glu Asn His Lys Glu 
                325                 330                 335     


Asp Leu Lys Lys Met Lys Arg Phe Val Arg Thr Tyr Leu Pro Glu Lys 
            340                 345                 350         


Tyr Asp Glu Ile Phe Asp Asp Thr Glu Lys His Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ser Gly Lys Thr Lys Gln Ala Asp Phe Tyr Lys Tyr Met Lys Ala 
    370                 375                 380                 


Thr Leu Glu Lys Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Asp Tyr Glu Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Lys Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Gln Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 
                565                 570                 575     


Asn Gln Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Met Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Thr Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Ala 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Val Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Asn Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Val Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Asp Asn Val Pro Pro Leu Glu Ile Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ile Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Tyr 
    930                 935                 940                 


Lys Thr Asp Gly Asn Lys Asp Thr Met Glu Thr Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Phe Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Asp  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Arg Tyr  Leu Glu Thr Val Lys  Lys Val Leu 
    1055                 1060                 1065             


Gly Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Asn Val Thr  Pro Asn Pro Lys Gly  Lys Ser Asn 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Lys  Asp Trp Asp Pro Ile  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Phe  Asp Gly Ser Lys Met  Ala Tyr Ala Ile Ile  Ile Glu Tyr 
    1115                 1120                 1125             


Glu Lys  Gln Lys Arg Lys Val  Arg Ile Glu Lys Lys  Leu Ile Gln 
    1130                 1135                 1140             


Ile Asn  Ile Met Glu Arg Glu  Ala Phe Glu Lys Asp  Glu Lys Thr 
    1145                 1150                 1155             


Phe Leu  Glu Glu Lys Gly Tyr  His Gln Pro Lys Val  Leu Ile Lys 
    1160                 1165                 1170             


Val Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Asn Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Gly Ser Ala Asn Glu  Ala His Lys Gly Asn  Gln Met Leu 
    1190                 1195                 1200             


Leu Pro  Asn His Leu Met Ala  Leu Leu Tyr His Ala  Glu Lys Tyr 
    1205                 1210                 1215             


Glu Ala  Ile Asp Gly Glu Ser  Leu Ala Tyr Ile Glu  Val His Arg 
    1220                 1225                 1230             


Ala Leu  Phe Asp Glu Leu Leu  Ala Tyr Ile Ser Glu  Phe Ala Arg 
    1235                 1240                 1245             


Lys Tyr  Thr Leu Ser Asn Asp  Arg Leu Asp Glu Ile  Asn Met Leu 
    1250                 1255                 1260             


Tyr Glu  Arg Asn Lys Asp Gly  Asp Val Lys Ser Ile  Ala Glu Ser 
    1265                 1270                 1275             


Phe Val  Ser Leu Lys Lys Phe  Asn Ala Phe Gly Val  His Gln Asp 
    1280                 1285                 1290             


Phe Ser  Phe Phe Gly Thr Lys  Ile Glu Arg Lys Arg  Asp Arg Lys 
    1295                 1300                 1305             


Leu Asn  Glu Leu Leu Asn Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asn 
    1325                 1330                 


<210>  538
<211>  1334
<212>  PRT
<213>  Listeria monocytogenes

<400>  538

Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asn Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Asp Gly Gln Thr Ala Val Asp Arg Arg Met 
    50                  55                  60                  


Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Val Glu Met Ala Asn Ile Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Gly Val Tyr Glu Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Met Ser Asn Ile Glu Glu Gly Thr Leu Ala Lys Val 
        195                 200                 205             


Glu Glu Asn Ile Glu Val Ala Asn Ile Leu Ala Arg Lys Phe Thr Arg 
    210                 215                 220                 


Arg Glu Lys Phe Glu Arg Ile Leu Gln Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Val Phe Asp Leu Ile Glu Lys Thr Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Thr Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Asp Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 
                325                 330                 335     


Asp Leu Val Glu Leu Lys Ala Phe Ile Lys Leu Asn Leu Pro Lys Gln 
            340                 345                 350         


Tyr Glu Glu Ile Phe Ser Asn Ala Ala Ile Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr Leu Lys Thr 
    370                 375                 380                 


Ile Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Ile His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Asp Tyr Glu Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Lys Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Ile Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Gln Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 
                565                 570                 575     


Asn His Val Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ala Ser Tyr Ala Thr Tyr His Asp Leu Met Lys Val Gly Ile Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Thr Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Ala 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Val Val Glu Glu Leu Val 
            740                 745                 750         


Ser Val Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Asn Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Asp Asn Val Pro Pro Leu Glu Ile Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ile Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Tyr 
    930                 935                 940                 


Lys Thr Asp Asp Asn Glu Asp Thr Met Glu Pro Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Glu  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Glu Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Asn Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Asn Gln Asn  Pro Lys Pro Arg Gly  Asp Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Lys Lys Thr  Asn Leu Asn Pro Ile  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Phe  Glu Gly Ser Asn Met  Ala Tyr Ala Ile Ile  Ile Glu His 
    1115                 1120                 1125             


Glu Lys  Arg Lys Lys Lys Val  Thr Ile Glu Lys Lys  Leu Ile Gln 
    1130                 1135                 1140             


Ile Asn  Ile Met Glu Arg Lys  Ala Phe Glu Lys Asp  Glu Lys Val 
    1145                 1150                 1155             


Phe Leu  Glu Gly Lys Gly Tyr  His Gln Pro Lys Val  Leu Thr Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Ala Leu Tyr  Glu Cys Glu Asn Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Gly Ser Ala Asn Glu  Val His Lys Gly Asn  Gln Met Leu 
    1190                 1195                 1200             


Leu Pro  Asn His Leu Met Thr  Leu Leu Tyr His Ala  Glu Lys Arg 
    1205                 1210                 1215             


Glu Ala  Ile Asp Gly Glu Ser  Leu Ala Tyr Ile Glu  Ala His Lys 
    1220                 1225                 1230             


Ala Val  Phe Gly Glu Leu Leu  Ala His Ile Ser Glu  Phe Ala Arg 
    1235                 1240                 1245             


Lys Tyr  Thr Leu Ala Asn Asp  Lys Leu Asp Glu Ile  Asn Met Leu 
    1250                 1255                 1260             


Tyr Glu  Arg Asn Lys Asp Gly  Asp Val Lys Ser Ile  Ala Glu Ser 
    1265                 1270                 1275             


Phe Val  Ser Leu Lys Lys Phe  Asn Ala Phe Gly Val  His Lys Asp 
    1280                 1285                 1290             


Phe Asn  Phe Phe Gly Thr Thr  Ile Lys Arg Lys Arg  Asp Arg Lys 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Asn Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Ser 
    1325                 1330                 


<210>  539
<211>  1337
<212>  PRT
<213>  Listeria monocytogenes

<400>  539

Met Lys Asn Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr 
1               5                   10                  15      


Asn Ser Val Gly Trp Ala Val Leu Thr Asn Gln Tyr Asp Leu Val Lys 
            20                  25                  30          


Arg Lys Met Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys 
        35                  40                  45              


Asn Phe Trp Gly Val Arg Leu Phe Asp Asp Gly Gln Thr Ala Val Asp 
    50                  55                  60                  


Arg Arg Met Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn 
65                  70                  75                  80  


Arg Ile Ser Tyr Leu Gln Glu Ile Phe Ala Val Glu Met Ala Asn Ile 
                85                  90                  95      


Asp Ala Asn Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser 
            100                 105                 110         


Glu Lys Arg Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu 
        115                 120                 125             


Val Ala Tyr His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu 
    130                 135                 140                 


Leu Val Asn Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala 
145                 150                 155                 160 


Leu Ala His Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala 
                165                 170                 175     


Leu Asp Thr Lys Asn Thr Ser Val Asp Gly Val Tyr Glu Gln Phe Ile 
            180                 185                 190         


Gln Thr Tyr Asn Gln Val Phe Met Ser Asn Ile Glu Glu Gly Thr Leu 
        195                 200                 205             


Ala Lys Val Glu Glu Asn Ile Glu Val Ala Asn Ile Leu Ala Gly Lys 
    210                 215                 220                 


Phe Thr Arg Arg Glu Lys Phe Glu Arg Ile Leu Gln Leu Tyr Pro Gly 
225                 230                 235                 240 


Glu Lys Ser Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly 
                245                 250                 255     


Ser Lys Gly Asn Phe Gln Lys Val Phe Asp Leu Ile Glu Lys Thr Asp 
            260                 265                 270         


Ile Glu Cys Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ala Leu Leu 
        275                 280                 285             


Ala Ile Ile Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn 
    290                 295                 300                 


Thr Tyr Asn Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Ala Thr 
305                 310                 315                 320 


Glu Thr Asn Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala 
                325                 330                 335     


His Glu Lys Asp Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu 
            340                 345                 350         


Pro Lys Gln Tyr Gln Glu Ile Phe Asn Asn Ala Ala Ile Asp Gly Tyr 
        355                 360                 365             


Ala Gly Tyr Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr 
    370                 375                 380                 


Leu Lys Thr Ile Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala 
385                 390                 395                 400 


Lys Ile Glu Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn 
                405                 410                 415     


Gly Ala Ile Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Ile 
            420                 425                 430         


His Gln Gln Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Asp Tyr Glu Lys 
        435                 440                 445             


Ile Lys Ser Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu 
    450                 455                 460                 


Ala Lys Gly Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly 
465                 470                 475                 480 


Glu Ile Arg Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser 
                485                 490                 495     


Ala Val Asp Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro 
            500                 505                 510         


Lys Glu Asn Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met 
        515                 520                 525             


Val Tyr Asn Glu Leu Thr Lys Val Arg Tyr Ile Asp Asp Gln Gly Lys 
    530                 535                 540                 


Thr Asn Tyr Phe Ser Gly Gln Glu Lys Gln Gln Ile Phe Asn Asp Leu 
545                 550                 555                 560 


Phe Lys Gln Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu 
                565                 570                 575     


Arg Asn Ile Asn His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp 
            580                 585                 590         


Ser Phe Asn Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly 
        595                 600                 605             


Met Lys Gln Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Met Leu Glu 
    610                 615                 620                 


Asp Ile Val Lys Ile Leu Thr Val Phe Glu Asp Lys Pro Met Ile Lys 
625                 630                 635                 640 


Glu Gln Leu Gln Gln Phe Ser Asp Val Leu Asp Gly Gly Val Leu Lys 
                645                 650                 655     


Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys 
            660                 665                 670         


Leu Leu Val Gly Ile Arg Glu Lys Gln Ser His Leu Thr Ile Leu Asp 
        675                 680                 685             


Tyr Leu Met Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile 
    690                 695                 700                 


Asn Asp Ser Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val 
705                 710                 715                 720 


Ser Thr Thr Asp Lys Asp Leu Gln Ser Ile Val Ala Asp Leu Ala Gly 
                725                 730                 735     


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp 
            740                 745                 750         


Glu Leu Val Ser Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu 
        755                 760                 765             


Met Ala Arg Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys 
    770                 775                 780                 


Pro Arg Tyr Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Lys 
785                 790                 795                 800 


Ile Leu Lys Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg 
                805                 810                 815     


Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln 
            820                 825                 830         


Glu Leu Asp Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val 
        835                 840                 845             


Pro Gln Ser Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr 
    850                 855                 860                 


Ser Ser Ala Gly Asn Arg Glu Lys Gly Gly Asp Val Pro Pro Leu Glu 
865                 870                 875                 880 


Ile Val Arg Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn 
                885                 890                 895     


Leu Met Ser Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly 
            900                 905                 910         


Gly Leu Thr Asp Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val 
        915                 920                 925             


Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg 
    930                 935                 940                 


Phe Asn Asn Glu Thr Asp Asn His Gly Asn Thr Met Glu Gln Val Arg 
945                 950                 955                 960 


Ile Val Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe 
                965                 970                 975     


Gln Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp 
            980                 985                 990         


Ala Tyr Leu Asn Gly Val Val Ala  Asn Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Gln Leu  Glu Pro Glu Phe Val  Tyr Gly Glu Tyr His  Gln Phe Asp 
    1010                 1015                 1020             


Trp Phe  Lys Ala Asn Lys Ala  Thr Ala Lys Lys Gln  Phe Tyr Thr 
    1025                 1030                 1035             


Asn Ile  Met Leu Phe Phe Gly  Gln Lys Glu Arg Ile  Ile Asp Glu 
    1040                 1045                 1050             


Asn Gly  Glu Ile Leu Trp Asp  Lys Lys Tyr Leu Glu  Thr Ile Lys 
    1055                 1060                 1065             


Lys Val  Leu Asp Tyr Arg Gln  Met Asn Ile Val Lys  Lys Thr Glu 
    1070                 1075                 1080             


Ile Gln  Lys Gly Glu Phe Ser  Lys Ala Thr Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Asn Ser  Ser Lys Leu Ile Pro  Arg Lys Glu Asn Trp  Asp Pro Met 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Leu Asp Ser  Pro Asn Met Ala Tyr  Ala Val Ile 
    1115                 1120                 1125             


Ile Glu  His Ala Lys Gly Lys  Lys Lys Leu Ile Phe  Glu Lys Lys 
    1130                 1135                 1140             


Ile Ile  Arg Ile Thr Ile Met  Glu Arg Lys Met Phe  Glu Lys Asp 
    1145                 1150                 1155             


Glu Glu  Ala Phe Leu Glu Glu  Lys Gly Tyr Arg His  Pro Lys Val 
    1160                 1165                 1170             


Leu Thr  Lys Leu Pro Lys Tyr  Thr Leu Tyr Glu Cys  Glu Lys Gly 
    1175                 1180                 1185             


Arg Arg  Arg Met Leu Ala Ser  Ala Asn Glu Ala Gln  Lys Gly Asn 
    1190                 1195                 1200             


Gln Leu  Val Leu Ser Asn His  Leu Val Ser Leu Leu  Tyr His Ala 
    1205                 1210                 1215             


Lys Asn  Cys Glu Ala Ser Asp  Gly Lys Ser Leu Lys  Tyr Ile Glu 
    1220                 1225                 1230             


Ala His  Arg Glu Thr Phe Ser  Glu Leu Leu Ala Gln  Val Ser Glu 
    1235                 1240                 1245             


Phe Ala  Thr Arg Tyr Thr Leu  Ala Asp Ala Asn Leu  Ser Lys Ile 
    1250                 1255                 1260             


Asn Asn  Leu Phe Glu Gln Asn  Lys Glu Gly Asp Ile  Gln Ala Ile 
    1265                 1270                 1275             


Ala Gln  Ser Phe Val Asp Leu  Met Ala Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ala  Ser Phe Lys Phe Phe  Glu Ala Thr Ile Asp  Arg Lys Arg 
    1295                 1300                 1305             


Tyr Thr  Asn Leu Lys Glu Leu  Leu Ser Ser Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Ile  Thr Gly Leu Tyr Glu  Ser Arg Lys Arg Leu  Asp Asp 
    1325                 1330                 1335         


<210>  540
<211>  1337
<212>  PRT
<213>  Listeria monocytogenes

<400>  540

Met Lys Asn Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr 
1               5                   10                  15      


Asn Ser Val Gly Trp Ala Val Leu Thr Asn Gln Tyr Asp Leu Val Lys 
            20                  25                  30          


Arg Lys Met Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys 
        35                  40                  45              


Asn Phe Trp Gly Val Arg Leu Phe Asp Asp Gly Gln Thr Ala Val Asp 
    50                  55                  60                  


Arg Arg Met Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn 
65                  70                  75                  80  


Arg Ile Ser Tyr Leu Gln Glu Ile Phe Ala Val Glu Met Ala Asn Ile 
                85                  90                  95      


Asp Ala Asn Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser 
            100                 105                 110         


Glu Lys Arg Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu 
        115                 120                 125             


Val Ala Tyr His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu 
    130                 135                 140                 


Leu Val Asn Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala 
145                 150                 155                 160 


Leu Ala His Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala 
                165                 170                 175     


Leu Asp Thr Lys Asn Thr Ser Val Asp Gly Val Tyr Glu Gln Phe Ile 
            180                 185                 190         


Gln Thr Tyr Asn Gln Val Phe Met Ser Asn Ile Glu Glu Gly Thr Leu 
        195                 200                 205             


Ala Lys Val Glu Glu Asn Ile Glu Val Ala Asn Ile Leu Ala Arg Lys 
    210                 215                 220                 


Phe Thr Arg Arg Glu Lys Phe Glu Arg Ile Leu Gln Leu Tyr Pro Gly 
225                 230                 235                 240 


Glu Lys Ser Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly 
                245                 250                 255     


Ser Lys Gly Asn Phe Gln Lys Val Phe Asp Leu Ile Glu Lys Thr Asp 
            260                 265                 270         


Ile Glu Cys Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Thr Leu Leu 
        275                 280                 285             


Ala Ile Ile Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn 
    290                 295                 300                 


Thr Tyr Asn Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Asp Thr 
305                 310                 315                 320 


Glu Thr Asn Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala 
                325                 330                 335     


His Glu Lys Asp Leu Val Glu Leu Lys Ala Phe Ile Lys Leu Asn Leu 
            340                 345                 350         


Pro Lys Gln Tyr Glu Glu Ile Phe Ser Asn Ala Ala Ile Asp Gly Tyr 
        355                 360                 365             


Ala Gly Tyr Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr 
    370                 375                 380                 


Leu Lys Thr Ile Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala 
385                 390                 395                 400 


Lys Ile Glu Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn 
                405                 410                 415     


Gly Ala Ile Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Ile 
            420                 425                 430         


His Gln Gln Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Asp Tyr Glu Lys 
        435                 440                 445             


Ile Lys Ser Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu 
    450                 455                 460                 


Ala Lys Gly Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly 
465                 470                 475                 480 


Glu Ile Arg Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser 
                485                 490                 495     


Ala Val Asp Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro 
            500                 505                 510         


Lys Glu Asn Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met 
        515                 520                 525             


Val Tyr Asn Glu Leu Thr Lys Ile Arg Tyr Ile Asp Asp Gln Gly Lys 
    530                 535                 540                 


Thr Asn Tyr Phe Ser Gly Gln Glu Lys Gln Gln Ile Phe Asn Asp Leu 
545                 550                 555                 560 


Phe Lys Gln Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu 
                565                 570                 575     


Arg Asn Ile Asn His Val Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp 
            580                 585                 590         


Ser Phe Asn Ala Ser Tyr Ala Thr Tyr His Asp Leu Met Lys Val Gly 
        595                 600                 605             


Ile Lys Gln Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Met Leu Glu 
    610                 615                 620                 


Asp Ile Val Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys 
625                 630                 635                 640 


Glu Gln Leu Gln Gln Phe Ser Asp Val Leu Asp Gly Thr Val Leu Lys 
                645                 650                 655     


Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys 
            660                 665                 670         


Leu Leu Val Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp 
        675                 680                 685             


Tyr Leu Met Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile 
    690                 695                 700                 


Asn Asp Ser Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val 
705                 710                 715                 720 


Ser Thr Ala Asp Lys Asp Leu Gln Ser Ile Val Ala Asp Leu Ala Gly 
                725                 730                 735     


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Val Val Glu 
            740                 745                 750         


Glu Leu Val Ser Val Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu 
        755                 760                 765             


Met Ala Arg Glu Asn Gln Thr Thr Asn Lys Gly Lys Asn Asn Ser Lys 
    770                 775                 780                 


Pro Arg Tyr Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln 
785                 790                 795                 800 


Ile Leu Lys Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg 
                805                 810                 815     


Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln 
            820                 825                 830         


Glu Leu Asp Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val 
        835                 840                 845             


Pro Gln Ser Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr 
    850                 855                 860                 


Ser Ser Ala Gly Asn Arg Glu Lys Gly Asp Asn Val Pro Pro Leu Glu 
865                 870                 875                 880 


Ile Val Gln Lys Arg Lys Ile Phe Trp Glu Lys Leu Tyr Gln Gly Asn 
                885                 890                 895     


Leu Met Ser Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly 
            900                 905                 910         


Gly Leu Thr Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val 
        915                 920                 925             


Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg 
    930                 935                 940                 


Phe Asn Tyr Lys Thr Asp Asp Asn Glu Asp Thr Met Glu Pro Val Arg 
945                 950                 955                 960 


Ile Val Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe 
                965                 970                 975     


Gln Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp 
            980                 985                 990         


Ala Tyr Leu Asn Gly Val Val Ala  Asn Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Gln Leu  Glu Pro Glu Phe Val  Tyr Gly Glu Tyr His  Gln Phe Asp 
    1010                 1015                 1020             


Trp Phe  Lys Ala Asn Lys Ala  Thr Ala Lys Lys Gln  Phe Tyr Thr 
    1025                 1030                 1035             


Asn Ile  Met Leu Phe Phe Ala  Gln Lys Glu Arg Ile  Ile Asp Glu 
    1040                 1045                 1050             


Asn Gly  Glu Ile Leu Trp Asp  Lys Lys Tyr Leu Glu  Thr Ile Lys 
    1055                 1060                 1065             


Lys Val  Leu Asn Tyr Arg Gln  Met Asn Ile Val Lys  Lys Thr Glu 
    1070                 1075                 1080             


Ile Gln  Lys Gly Glu Phe Ser  Asn Gln Asn Pro Lys  Pro Arg Gly 
    1085                 1090                 1095             


Asp Ser  Ser Lys Leu Ile Pro  Lys Lys Thr Asn Leu  Asn Pro Ile 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Glu Gly  Ser Asn Met Ala Tyr  Ala Ile Ile 
    1115                 1120                 1125             


Ile Glu  His Glu Lys Arg Lys  Lys Lys Val Thr Ile  Glu Lys Lys 
    1130                 1135                 1140             


Leu Ile  Gln Ile Asn Ile Met  Glu Arg Lys Ala Phe  Glu Lys Asp 
    1145                 1150                 1155             


Glu Lys  Val Phe Leu Glu Gly  Lys Gly Tyr His Gln  Pro Lys Val 
    1160                 1165                 1170             


Leu Thr  Lys Leu Pro Lys Tyr  Ala Leu Tyr Glu Cys  Glu Asn Gly 
    1175                 1180                 1185             


Arg Arg  Arg Met Leu Gly Ser  Ala Asn Glu Val His  Lys Gly Asn 
    1190                 1195                 1200             


Gln Met  Leu Leu Pro Asn His  Leu Met Thr Leu Leu  Tyr His Ala 
    1205                 1210                 1215             


Glu Lys  Arg Glu Ala Ile Asp  Gly Glu Ser Leu Ala  Tyr Ile Glu 
    1220                 1225                 1230             


Ala His  Lys Ala Val Phe Gly  Glu Leu Leu Ala His  Ile Ser Glu 
    1235                 1240                 1245             


Phe Ala  Arg Lys Tyr Thr Leu  Ala Asn Asp Lys Leu  Asp Glu Ile 
    1250                 1255                 1260             


Asn Met  Leu Tyr Glu Arg Asn  Lys Asp Gly Asp Val  Lys Ser Ile 
    1265                 1270                 1275             


Ala Glu  Ser Phe Val Ser Leu  Lys Lys Phe Asn Ala  Phe Gly Val 
    1280                 1285                 1290             


His Lys  Asp Phe Asn Phe Phe  Gly Thr Thr Ile Lys  Arg Lys Arg 
    1295                 1300                 1305             


Asp Arg  Lys Leu Lys Glu Leu  Leu Asn Ser Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Ile  Thr Gly Leu Tyr Glu  Ser Arg Lys Arg Leu  Asp Ser 
    1325                 1330                 1335         


<210>  541
<211>  782
<212>  PRT
<213>  Unknown

<220>
<223>  Listeria monocytogenes FSL F2-208


<220>
<221>  misc_feature
<222>  (722)..(722)
<223>  Xaa can be any naturally occurring amino acid

<400>  541

Ile Phe Asn Asp Leu Phe Lys Gln Lys Arg Lys Val Lys Lys Lys Asp 
1               5                   10                  15      


Leu Glu Leu Phe Leu Arg Asn Ile Asn Gln Ile Glu Ser Pro Thr Ile 
            20                  25                  30          


Glu Gly Leu Glu Asp Ser Phe Asn Ala Ser Tyr Ala Thr Tyr His Asp 
        35                  40                  45              


Leu Leu Lys Val Gly Met Lys Gln Glu Ile Leu Asp Asn Pro Leu Asn 
    50                  55                  60                  


Thr Glu Met Leu Glu Asp Ile Val Lys Ile Leu Thr Val Phe Glu Asp 
65                  70                  75                  80  


Lys Arg Met Ile Lys Glu Gln Leu Gln Gln Phe Ser Asp Val Leu Asp 
                85                  90                  95      


Gly Val Val Leu Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly 
            100                 105                 110         


Arg Leu Ser Ala Lys Leu Leu Val Gly Ile Arg Asp Lys Gln Ser His 
        115                 120                 125             


Leu Thr Ile Leu Glu Tyr Leu Met Asn Asp Asp Gly Leu Asn Arg Asn 
    130                 135                 140                 


Leu Met Gln Leu Ile Asn Asp Ser Asn Leu Ser Phe Lys Ser Ile Ile 
145                 150                 155                 160 


Glu Lys Glu Gln Val Ser Thr Thr Asp Lys Asp Leu Gln Ser Ile Val 
                165                 170                 175     


Ala Asp Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser 
            180                 185                 190         


Leu Lys Ile Val Asp Glu Leu Val Ser Ile Met Gly Tyr Pro Pro Gln 
        195                 200                 205             


Thr Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Val Lys Gly 
    210                 215                 220                 


Lys Asn Asn Ser Arg Pro Arg Tyr Lys Ser Leu Glu Lys Ala Ile Lys 
225                 230                 235                 240 


Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro Thr Asp Asn Gln Glu 
                245                 250                 255     


Leu Lys Asn Asn Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp 
            260                 265                 270         


Ile Tyr Thr Gly Gln Glu Leu Asp Ile His Asn Leu Ser Asn Tyr Asp 
        275                 280                 285             


Ile Asp His Ile Val Pro Gln Ser Phe Ile Thr Asp Asn Ser Ile Asp 
    290                 295                 300                 


Asn Leu Val Leu Thr Ser Ser Ala Gly Asn Arg Glu Lys Gly Asp Asp 
305                 310                 315                 320 


Val Pro Pro Leu Glu Ile Val Arg Lys Arg Lys Val Phe Trp Glu Lys 
                325                 330                 335     


Leu Tyr Gln Gly Asn Leu Met Ser Lys Arg Lys Phe Asp Tyr Leu Thr 
            340                 345                 350         


Lys Ala Glu Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Arg Phe Ile 
        355                 360                 365             


His Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Asn 
    370                 375                 380                 


Ile Leu His Gln Arg Phe Asn Asn Glu Thr Asp Asn His Gly Asn Thr 
385                 390                 395                 400 


Met Glu Gln Val Arg Ile Val Thr Leu Lys Ser Ala Leu Val Ser Gln 
                405                 410                 415     


Phe Arg Lys Gln Phe Gln Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr 
            420                 425                 430         


His His Ala His Asp Ala Tyr Leu Asn Gly Val Val Ala Asn Thr Leu 
        435                 440                 445             


Leu Lys Val Tyr Pro Gln Leu Glu Pro Glu Phe Val Tyr Gly Glu Tyr 
    450                 455                 460                 


His Gln Phe Asp Trp Phe Lys Ala Asn Lys Ala Thr Ala Lys Lys Gln 
465                 470                 475                 480 


Phe Tyr Thr Asn Ile Met Leu Phe Phe Ala Gln Lys Glu Arg Ile Ile 
                485                 490                 495     


Asp Glu Asn Gly Glu Ile Leu Trp Asp Lys Lys Tyr Leu Glu Thr Ile 
            500                 505                 510         


Lys Lys Val Leu Asp Tyr Arg Gln Met Asn Ile Val Lys Lys Thr Glu 
        515                 520                 525             


Ile Gln Lys Gly Glu Phe Ser Lys Ala Thr Ile Lys Pro Lys Gly Asn 
    530                 535                 540                 


Ser Ser Lys Leu Ile Pro Arg Lys Glu Asn Trp Asp Pro Met Lys Tyr 
545                 550                 555                 560 


Gly Gly Leu Asp Ser Pro Asn Met Ala Tyr Ala Val Ile Ile Glu His 
                565                 570                 575     


Ala Lys Gly Lys Lys Lys Ile Val Ile Glu Lys Lys Leu Ile Gln Ile 
            580                 585                 590         


Asn Ile Met Glu Arg Lys Met Phe Glu Lys Asp Glu Glu Ala Phe Leu 
        595                 600                 605             


Glu Glu Lys Gly Tyr Arg His Pro Lys Val Leu Thr Lys Leu Pro Lys 
    610                 615                 620                 


Tyr Thr Leu Tyr Glu Cys Glu Lys Gly Arg Arg Arg Met Leu Ala Ser 
625                 630                 635                 640 


Ala Asn Glu Ala Gln Lys Gly Asn Gln Leu Val Leu Ser Asn His Leu 
                645                 650                 655     


Val Ser Leu Leu Tyr His Ala Lys Asn Cys Glu Ala Ser Asp Gly Lys 
            660                 665                 670         


Ser Leu Lys Tyr Thr Glu Ala His Arg Glu Thr Phe Ser Glu Leu Leu 
        675                 680                 685             


Ala Gln Val Ser Glu Phe Ala Thr Arg Tyr Thr Leu Ala Asp Ala Asn 
    690                 695                 700                 


Leu Ser Lys Ile Asn Asn Leu Phe Glu Gln Asn Lys Glu Gly Asp Ile 
705                 710                 715                 720 


Lys Xaa Ile Ala Gln Ser Phe Val Asp Leu Met Val Phe Asn Ala Met 
                725                 730                 735     


Gly Ala Pro Ala Ser Phe Lys Phe Phe Glu Ala Thr Ile Asp Arg Lys 
            740                 745                 750         


Arg Tyr Thr Asn Leu Lys Glu Leu Leu Ser Ser Thr Ile Ile Tyr Gln 
        755                 760                 765             


Ser Ile Thr Gly Leu Tyr Glu Ser Arg Lys Arg Leu Asp Asp 
    770                 775                 780         


<210>  542
<211>  1334
<212>  PRT
<213>  Listeria seeligeri

<400>  542

Met Lys Lys Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Ala Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Ser Glu Lys Lys Gln Ile Lys Lys Asn Leu Trp 
        35                  40                  45              


Gly Val Arg Leu Val Asp Glu Gly Lys Thr Ala Ala His Arg Arg Val 
    50                  55                  60                  


Asn Arg Thr Thr Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Thr Ala Glu Met Phe Glu Val Asp Ala Asn 
                85                  90                  95      


Phe Phe Tyr Arg Leu Glu Asp Ser Phe Tyr Ile Glu Ser Glu Lys Arg 
            100                 105                 110         


Gln Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Glu Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Lys Leu Val Asn 
    130                 135                 140                 


Ser Ser Asp Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Lys Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Glu Val Phe Lys Gln Phe Ile Lys Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Ala Ser Asp Ile Glu Glu Gly Ser Leu Thr Arg Ile 
        195                 200                 205             


Glu Glu Asn Asn Glu Val Ala Lys Ile Phe Ser Glu Lys Leu Thr Lys 
    210                 215                 220                 


Arg Glu Lys Leu Asp Lys Ile Leu Asn Leu Tyr Pro Asn Glu Lys Ser 
225                 230                 235                 240 


Thr Asp Leu Phe Ala Gln Phe Ile Ser Leu Ile Ile Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Lys Lys Phe Phe Asn Leu Thr Glu Lys Thr Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Val Leu Leu Ala Arg Val 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Ile Phe Val Ala Ala Lys Asn Ala Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Ser Asn Thr Glu Thr Lys 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Lys His Asp Lys 
                325                 330                 335     


Asp Leu Lys Arg Met Lys Ala Phe Phe Lys Val Arg Leu Pro Glu Asn 
            340                 345                 350         


Phe Asn Glu Val Phe Asn Asp Val Glu Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Glu Gly Lys Thr Lys Gln Glu Ala Phe Tyr Lys Tyr Met Lys Lys 
    370                 375                 380                 


Met Leu Glu His Val Glu Gly Ala Asp Tyr Phe Ile Asn Gln Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Lys Val Asp Tyr Glu Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ser Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Ile Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Met Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Ile Arg Tyr Thr Asp Asp Gln Gly Lys Thr His Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Gln Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Tyr Asn Met 
                565                 570                 575     


Asn His Val Glu Ser Pro Thr Val Glu Gly Val Glu Asp Ala Phe Asn 
            580                 585                 590         


Ser Ser Phe Thr Thr Tyr His Asp Leu Gln Lys Val Gly Val Pro Gln 
        595                 600                 605             


Glu Ile Leu Asp Asp Pro Leu Asn Thr Glu Met Leu Glu Glu Ile Ile 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Asn Glu Arg Leu 
625                 630                 635                 640 


Gln Glu Phe Ser Asn Val Leu Asp Glu Ala Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Ile 
            660                 665                 670         


Gly Ile Arg Asp Lys Glu Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Lys His Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Ala 
705                 710                 715                 720 


Asp Lys Asp Ile Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Gly Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys Pro Arg Phe 
    770                 775                 780                 


Thr Ser Leu Glu Lys Ala Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Gly Leu Lys Asn Asp Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Val Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Arg Val Leu Ala Ser Ser Ala 
    850                 855                 860                 


Ala Asn Arg Glu Lys Gly Asp Asn Val Pro Ser Leu Glu Val Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Tyr Trp Glu Lys Leu Tyr Gln Ala Lys Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Cys 
    930                 935                 940                 


Lys Lys Asp Glu Ser Gly Asn Val Ile Glu Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ala Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Cys Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Lys Lys Asp  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Asp Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Asn Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Asn Ala Thr  Ala Asn Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Ala  Asp Trp Asp Pro Ile  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Phe  Asp Gly Ser Asn Met  Ala Tyr Ala Ile Val  Ile Glu His 
    1115                 1120                 1125             


Glu Lys  Arg Lys Lys Lys Thr  Val Ile Lys Lys Glu  Leu Ile Gln 
    1130                 1135                 1140             


Ile Asn  Ile Met Glu Arg Thr  Ala Phe Glu Lys Asp  Gln Lys Glu 
    1145                 1150                 1155             


Phe Leu  Glu Gly Lys Gly Tyr  Arg Asn Pro Lys Val  Ile Thr Lys 
    1160                 1165                 1170             


Ile Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Asn Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Gly Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Met Val 
    1190                 1195                 1200             


Leu Pro  Asn His Leu Met Thr  Leu Leu Tyr His Ala  Lys Asn Cys 
    1205                 1210                 1215             


Glu Ala  Ser Asp Gly Lys Ser  Leu Ala Tyr Ile Glu  Ser His Arg 
    1220                 1225                 1230             


Glu Met  Phe Ala Glu Leu Leu  Asp Ser Ile Ser Glu  Phe Ala Ser 
    1235                 1240                 1245             


Arg Tyr  Thr Leu Ala Asp Ala  Asn Leu Glu Lys Ile  Asn Thr Ile 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Ser Gly  Asp Val Lys Val Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asn Leu Leu Glu Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Tyr Phe Glu Thr Asn  Ile Glu Arg Lys Arg  Tyr Asn Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Asn Ala  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ala Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210>  543
<211>  1400
<212>  PRT
<213>  Unknown

<220>
<223>  Plant multiplex genome editing vector pYLCRISPR/Cas9Pubi-H

<400>  543

Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Lys  Arg Pro Ala Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys 
    1385                 1390                 1395             


Lys Lys  
    1400 


<210>  544
<211>  1333
<212>  PRT
<213>  Roseburia hominis

<400>  544

Met Ser Gln Asn Ile Val Asp Tyr Cys Ile Gly Leu Asp Leu Gly Thr 
1               5                   10                  15      


Gly Ser Val Gly Trp Ala Val Val Asp Met Asn His Arg Leu Met Lys 
            20                  25                  30          


Arg Asn Gly Lys His Leu Trp Gly Ser Arg Leu Phe Ser Asn Ala Glu 
        35                  40                  45              


Thr Ala Ala Thr Arg Arg Ser Ser Arg Ser Ile Arg Arg Arg Tyr Asn 
    50                  55                  60                  


Lys Arg Arg Glu Arg Ile Arg Leu Leu Arg Ala Ile Leu Gln Asp Met 
65                  70                  75                  80  


Val Leu Glu Lys Asp Pro Thr Phe Phe Ile Arg Leu Glu His Thr Ser 
                85                  90                  95      


Phe Leu Asp Glu Glu Asp Lys Ala Lys Tyr Leu Gly Thr Asp Tyr Lys 
            100                 105                 110         


Asp Asn Tyr Asn Leu Phe Ile Asp Glu Asp Phe Asn Asp Tyr Thr Tyr 
        115                 120                 125             


Tyr His Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Ala Leu Cys Glu 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Pro Arg Leu Ile Tyr Leu Ala Leu His His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly Asn Phe Leu Tyr Glu Gly Gln Lys Phe Asn 
                165                 170                 175     


Met Asp Ala Ser Asn Ile Glu Asp Lys Leu Ser Asp Val Phe Thr Gln 
            180                 185                 190         


Phe Ala Asp Phe Asn Asn Ile Pro Tyr Glu Asp Asp Glu Lys Lys Asn 
        195                 200                 205             


Leu Glu Ile Leu Glu Ile Leu Lys Lys Pro Leu Ser Lys Lys Ala Lys 
    210                 215                 220                 


Val Asp Glu Val Met Ala Leu Ile Ser Pro Glu Lys Glu Phe Lys Ser 
225                 230                 235                 240 


Ala Tyr Lys Glu Leu Val Thr Gly Ile Ala Gly Asn Lys Met Asn Val 
                245                 250                 255     


Thr Lys Met Ile Leu Cys Glu Ser Ile Lys Gln Gly Asp Ser Glu Ile 
            260                 265                 270         


Lys Leu Lys Phe Ser Asp Ser Asn Tyr Asp Asp Gln Phe Ser Glu Val 
        275                 280                 285             


Glu Asn Asp Leu Gly Glu Tyr Val Glu Phe Ile Asp Ser Leu His Asn 
    290                 295                 300                 


Ile Tyr Ser Trp Val Glu Leu Gln Thr Ile Met Gly Ala Thr His Thr 
305                 310                 315                 320 


Asp Asn Ala Ser Ile Ser Glu Ala Met Val Ser Arg Tyr Asn Lys His 
                325                 330                 335     


His Glu Asp Leu Gln Leu Leu Lys Lys Cys Ile Lys Asp Asn Val Pro 
            340                 345                 350         


Lys Lys Tyr Phe Asp Met Phe Arg Asn Asp Ser Glu Lys Val Lys Gly 
        355                 360                 365             


Tyr Tyr Asn Tyr Ile Asn Arg Pro Asn Lys Ala Pro Val Asp Glu Phe 
    370                 375                 380                 


Tyr Lys Phe Val Lys Lys Cys Ile Glu Lys Val Asp Thr Pro Glu Ala 
385                 390                 395                 400 


Lys Gln Ile Leu His Asp Ile Glu Leu Glu Asn Phe Leu Leu Lys Gln 
                405                 410                 415     


Asn Ser Arg Thr Asn Gly Ser Val Pro Tyr Gln Met Gln Leu Asp Glu 
            420                 425                 430         


Met Ile Lys Ile Ile Asp Asn Gln Ala Lys Tyr Tyr Pro Val Leu Lys 
        435                 440                 445             


Glu Lys Arg Glu Gln Leu Leu Ser Ile Leu Thr Phe Arg Ile Pro Tyr 
    450                 455                 460                 


Tyr Phe Gly Pro Leu Asn Glu Thr Ser Glu His Ala Trp Ile Lys Arg 
465                 470                 475                 480 


Leu Glu Gly Lys Glu Asn Gln Arg Ile Leu Pro Trp Asn Tyr Gln Asp 
                485                 490                 495     


Thr Val Asp Val Asp Ala Thr Ala Glu Gly Phe Ile Lys Arg Met Arg 
            500                 505                 510         


Ser Tyr Cys Thr Tyr Phe Pro Asp Glu Glu Val Leu Pro Lys Asn Ser 
        515                 520                 525             


Leu Ile Val Ser Lys Tyr Glu Val Tyr Asn Glu Leu Asn Lys Ile Arg 
    530                 535                 540                 


Val Asp Asp Lys Leu Leu Glu Val Asp Val Lys Asn Asp Ile Tyr Asn 
545                 550                 555                 560 


Glu Leu Phe Met Lys Asn Lys Thr Val Thr Glu Lys Lys Leu Lys Asn 
                565                 570                 575     


Trp Leu Val Asn Asn Gln Cys Cys Arg Lys Asp Ala Glu Ile Lys Gly 
            580                 585                 590         


Phe Gln Lys Glu Asn Gln Phe Ser Thr Ser Leu Thr Pro Trp Ile Asp 
        595                 600                 605             


Phe Thr Asn Ile Phe Gly Lys Ile Asp Gln Ser Asn Phe Asp Leu Ile 
    610                 615                 620                 


Glu Lys Ile Ile Tyr Asp Leu Thr Val Phe Glu Asp Lys Lys Ile Met 
625                 630                 635                 640 


Lys Arg Arg Leu Lys Lys Lys Tyr Ala Leu Pro Asp Asp Lys Ile Lys 
                645                 650                 655     


Gln Ile Leu Lys Leu Lys Tyr Lys Asp Trp Ser Arg Leu Ser Lys Lys 
            660                 665                 670         


Leu Leu Asp Gly Ile Val Ala Asp Asn Arg Phe Gly Ser Ser Val Thr 
        675                 680                 685             


Val Leu Asp Val Leu Glu Met Ser Arg Leu Asn Leu Met Glu Ile Ile 
    690                 695                 700                 


Asn Asp Lys Glu Leu Gly Tyr Ala Gln Met Ile Glu Glu Ala Ser Ser 
705                 710                 715                 720 


Cys Pro Lys Asp Gly Lys Phe Thr Tyr Glu Glu Val Ala Lys Leu Ala 
                725                 730                 735     


Gly Ser Pro Ala Leu Lys Arg Gly Ile Trp Gln Ser Leu Gln Ile Val 
            740                 745                 750         


Glu Glu Ile Thr Lys Val Met Lys Cys Arg Pro Lys Tyr Ile Tyr Ile 
        755                 760                 765             


Glu Phe Glu Arg Ser Glu Glu Ala Lys Glu Arg Thr Glu Ser Lys Ile 
    770                 775                 780                 


Lys Lys Leu Glu Asn Val Tyr Lys Asp Leu Asp Glu Gln Thr Lys Lys 
785                 790                 795                 800 


Glu Tyr Lys Ser Val Leu Glu Glu Leu Lys Gly Phe Asp Asn Thr Lys 
                805                 810                 815     


Lys Ile Ser Ser Asp Ser Leu Phe Leu Tyr Phe Thr Gln Leu Gly Lys 
            820                 825                 830         


Cys Met Tyr Ser Gly Lys Lys Leu Asp Ile Asp Ser Leu Asp Lys Tyr 
        835                 840                 845             


Gln Ile Asp His Ile Val Pro Gln Ser Leu Val Lys Asp Asp Ser Phe 
    850                 855                 860                 


Asp Asn Arg Val Leu Val Leu Pro Ser Glu Asn Gln Arg Lys Leu Asp 
865                 870                 875                 880 


Asp Leu Val Val Pro Phe Asp Ile Arg Asp Lys Met Tyr Arg Phe Trp 
                885                 890                 895     


Lys Leu Leu Phe Asp His Glu Leu Ile Ser Pro Lys Lys Phe Tyr Ser 
            900                 905                 910         


Leu Ile Lys Thr Glu Tyr Thr Glu Arg Asp Glu Glu Arg Phe Ile Asn 
        915                 920                 925             


Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Thr Gln Ile 
    930                 935                 940                 


Ile Glu Asp His Tyr Ser Thr Thr Lys Val Ala Ala Ile Arg Ala Asn 
945                 950                 955                 960 


Leu Ser His Glu Phe Arg Val Lys Asn His Ile Tyr Lys Asn Arg Asp 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Ile Val Ala Leu Ile 
            980                 985                 990         


Gly Gly Phe Met Arg Asp Arg Tyr  Pro Asn Met His Asp  Ser Lys Ala 
        995                 1000                 1005             


Val Tyr  Ser Glu Tyr Met Lys  Met Phe Arg Lys Asn  Lys Asn Asp 
    1010                 1015                 1020             


Gln Lys  Lys Trp Lys Asp Gly  Phe Val Ile Asn Ser  Met Asn Tyr 
    1025                 1030                 1035             


Pro Tyr  Glu Val Asp Gly Lys  Leu Ile Trp Asn Pro  Asp Leu Ile 
    1040                 1045                 1050             


Asn Glu  Ile Lys Lys Cys Phe  Tyr Tyr Lys Asp Cys  Tyr Cys Thr 
    1055                 1060                 1065             


Thr Lys  Leu Asp Gln Lys Ser  Gly Gln Met Phe Asn  Leu Thr Val 
    1070                 1075                 1080             


Leu Pro  Asn Asp Ala His Ser  Ala Lys Gly Thr Thr  Glu Ala Val 
    1085                 1090                 1095             


Ile Pro  Val Asn Lys Asn Arg  Lys Asp Val Asn Lys  Tyr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Gly Leu Gln Tyr Val  Ile Ala Ala Ile Glu  Gly Thr Lys 
    1115                 1120                 1125             


Lys Lys  Gly Lys Lys Leu Val  Lys Val Arg Lys Leu  Ser Gly Ile 
    1130                 1135                 1140             


Pro Leu  Tyr Leu Lys Gln Ala  Asp Ile Lys Glu Gln  Ile Glu Tyr 
    1145                 1150                 1155             


Val Glu  Lys Glu Glu Lys Leu  Ser Asp Val Lys Ile  Ile Lys Asn 
    1160                 1165                 1170             


Asn Ile  Pro Leu Asn Gln Leu  Ile Glu Ile Asp Gly  Arg Gln Tyr 
    1175                 1180                 1185             


Leu Leu  Thr Ser Pro Thr Glu  Cys Val Asn Ala Met  Gln Leu Val 
    1190                 1195                 1200             


Leu Asn  Glu Glu Gln Cys Lys  Leu Ile Ala Asp Ile  Tyr Asn Ala 
    1205                 1210                 1215             


Ile Tyr  Lys Gln Asp Phe Asp  Gly Leu Asp Asn Met  Leu Met Ile 
    1220                 1225                 1230             


Gln Leu  Tyr Leu Gln Leu Ile  Asp Lys Leu Lys Thr  Leu Tyr Pro 
    1235                 1240                 1245             


Ile Tyr  Met Gly Ile Val Glu  Lys Phe Glu Lys Leu  Thr Glu Asp 
    1250                 1255                 1260             


Phe Val  Ser Ile Ser Lys Glu  Glu Lys Ala Asn Val  Ile Lys Gln 
    1265                 1270                 1275             


Met Leu  Ile Ile Met His Lys  Gly Pro Gln Asn Gly  Asn Ile Ile 
    1280                 1285                 1290             


Tyr Asp  Asp Phe Asn Val Gly  Lys Arg Ile Gly Arg  Leu Asn Gly 
    1295                 1300                 1305             


Arg Thr  Phe Tyr Leu Asp Asn  Ile Glu Phe Ile Ser  Gln Ser Pro 
    1310                 1315                 1320             


Thr Gly  Ile Tyr Thr Lys Lys  Tyr Lys Leu 
    1325                 1330             


<210>  545
<211>  1335
<212>  PRT
<213>  Sharpea azabuensis

<400>  545

Met Ala Lys Asn Lys Asp Ile Arg Tyr Ser Ile Gly Leu Asp Ile Gly 
1               5                   10                  15      


Thr Asn Ser Val Gly Trp Ala Val Met Asp Glu His Tyr Glu Leu Leu 
            20                  25                  30          


Lys Lys Gly Asn His His Met Trp Gly Ser Arg Leu Phe Asp Ala Ala 
        35                  40                  45              


Glu Pro Ala Ala Thr Arg Arg Ala Ser Arg Ser Ile Arg Arg Arg Tyr 
    50                  55                  60                  


Asn Lys Arg Arg Glu Arg Ile Arg Leu Leu Arg Asp Leu Leu Gly Asp 
65                  70                  75                  80  


Met Val Met Glu Val Asp Pro Thr Phe Phe Ile Arg Leu Leu Asn Val 
                85                  90                  95      


Ser Phe Leu Asp Glu Glu Asp Lys Gln Lys Asn Leu Gly Asn Asp Tyr 
            100                 105                 110         


Lys Asp Asn Tyr Asn Leu Phe Ile Glu Lys Asp Phe Asn Asp Lys Thr 
        115                 120                 125             


Tyr Tyr Asp Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Cys 
    130                 135                 140                 


Glu Asn Lys Glu Lys Ala Asp Pro Arg Leu Ile Tyr Leu Ala Leu His 
145                 150                 155                 160 


His Ile Val Lys Tyr Arg Gly Asn Phe Leu Tyr Glu Gly Gln Ser Phe 
                165                 170                 175     


Thr Met Asp Asn Ser Asp Ile Glu Glu Arg Leu Asn Ser Ala Ile Glu 
            180                 185                 190         


Lys Phe Met Ser Ile Asn Glu Phe Asp Asn Arg Ile Val Glu Ser Asp 
        195                 200                 205             


Ile Asn Ser Met Ile Ala Val Leu Ser Lys Ile Tyr Gln Arg Ser Lys 
    210                 215                 220                 


Lys Ala Asp Asp Leu Leu Lys Ile Met Asn Pro Thr Lys Glu Glu Lys 
225                 230                 235                 240 


Ala Ala Tyr Lys Glu Phe Thr Lys Ala Leu Val Gly Leu Lys Phe Asn 
                245                 250                 255     


Ile Ser Lys Met Ile Leu Ala Gln Glu Val Lys Lys Gly Asp Thr Asp 
            260                 265                 270         


Ile Val Leu Glu Phe Ser Asn Ala Asn Tyr Asp Ser Thr Ile Asp Glu 
        275                 280                 285             


Leu Gln Ser Glu Leu Gly Glu Tyr Ile Glu Phe Ile Glu Met Leu His 
    290                 295                 300                 


Asn Ile Tyr Ser Trp Val Glu Leu Gln Ala Ile Leu Gly Ala Thr His 
305                 310                 315                 320 


Thr Asp Asn Pro Ser Ile Ser Ala Ala Met Val Glu Arg Tyr Glu Glu 
                325                 330                 335     


His Lys Lys Asp Leu Arg Val Leu Lys Lys Val Ile Arg Glu Glu Leu 
            340                 345                 350         


Pro Asp Lys Tyr Asn Glu Val Phe Arg Lys Asp Asn Arg Lys Leu His 
        355                 360                 365             


Asn Tyr Leu Gly Tyr Ile Lys Tyr Pro Lys Asp Thr Pro Val Glu Glu 
    370                 375                 380                 


Phe Tyr Lys Tyr Ile Lys Gly Leu Leu Ala Lys Val Asp Thr Asp Glu 
385                 390                 395                 400 


Ala Arg Glu Ile Leu Glu Arg Ile Asp Leu Glu Lys Phe Met Leu Lys 
                405                 410                 415     


Gln Asn Ser Arg Thr Asn Gly Ser Ile Pro Tyr Gln Met Gln Lys Asp 
            420                 425                 430         


Glu Met Ile Gln Ile Ile Asp Asn Gln Ser Val Tyr Tyr Pro Gln Leu 
        435                 440                 445             


Lys Glu Asn Arg Asp Lys Leu Ile Ser Ile Leu Glu Phe Arg Ile Pro 
    450                 455                 460                 


Tyr Tyr Phe Gly Pro Leu Asn Ala His Ser Glu Phe Ala Trp Ile Lys 
465                 470                 475                 480 


Lys Phe Glu Asp Lys Gln Lys Glu Arg Ile Leu Pro Trp Asn Tyr Asp 
                485                 490                 495     


Gln Ile Val Asp Ile Asp Ala Thr Ala Glu Gly Phe Ile Glu Arg Met 
            500                 505                 510         


Lys Asn Thr Gly Thr Tyr Phe Pro Asp Glu Pro Val Met Ala Lys Asn 
        515                 520                 525             


Ser Leu Thr Val Ser Lys Phe Glu Val Leu Asn Glu Leu Asn Lys Ile 
    530                 535                 540                 


Arg Ile Asn Gly Lys Leu Ile Ala Val Glu Thr Lys Lys Glu Leu Leu 
545                 550                 555                 560 


Ser Asp Leu Phe Met Lys Asn Lys Thr Ile Thr Asp Lys Lys Leu Lys 
                565                 570                 575     


Asp Trp Leu Val Thr His Gln Tyr Tyr Asp Ile Asn Glu Glu Leu Lys 
            580                 585                 590         


Ile Glu Gly Tyr Gln Lys Asp Leu Gln Phe Ser Thr Ser Leu Ala Pro 
        595                 600                 605             


Trp Ile Asp Phe Thr Lys Ile Phe Gly Glu Ile Asn Ala Ser Asn Tyr 
    610                 615                 620                 


Gln Leu Ile Glu Lys Ile Ile Tyr Asp Ile Ser Ile Phe Glu Asp Lys 
625                 630                 635                 640 


Lys Ile Leu Lys Arg Arg Leu Lys Lys Val Tyr Gln Leu Asp Asp Leu 
                645                 650                 655     


Leu Val Asp Lys Ile Leu Lys Leu Asn Tyr Thr Gly Trp Ser Arg Leu 
            660                 665                 670         


Ser Glu Lys Leu Leu Thr Gly Met Thr Ala Asp Asn Glu Phe Gly Ser 
        675                 680                 685             


Lys Ala Thr Val Leu Phe Val Leu Glu Asn Ser Asn Lys Asn Leu Met 
    690                 695                 700                 


Glu Ile Ile Asn Asp Glu Lys Leu Gly Tyr Lys Gln Ile Ile Glu Glu 
705                 710                 715                 720 


Ser Asn Met Gln Asp Ile Glu Gly Pro Phe Lys Tyr Asp Glu Val Lys 
                725                 730                 735     


Lys Leu Ala Gly Ser Pro Ala Ile Lys Arg Gly Ile Trp Gln Ala Leu 
            740                 745                 750         


Leu Val Val Arg Glu Ile Thr Lys Phe Met Lys His Glu Pro Ser His 
        755                 760                 765             


Ile Tyr Ile Glu Phe Ala Arg Glu Glu Gln Glu Lys Val Arg Lys Glu 
    770                 775                 780                 


Ser Lys Ile Ala Lys Leu Gln Lys Ile Tyr Glu Asn Leu Asn Leu Gln 
785                 790                 795                 800 


Thr Lys Glu Asp Gln Gln Val Tyr Glu Ser Leu Lys Lys Glu Asp Ala 
                805                 810                 815     


Lys Lys Arg Met Glu Thr Asp Ala Leu Tyr Leu Tyr Tyr Leu Gln Met 
            820                 825                 830         


Gly Lys Ser Met Tyr Ser Gly Lys Pro Leu Asp Ile Asp Lys Leu Ser 
        835                 840                 845             


Thr Tyr Gln Ile Asp His Ile Leu Pro Gln Ser Leu Ile Lys Asp Asp 
    850                 855                 860                 


Ser Phe Asp Asn Arg Val Leu Val Leu Pro Glu Glu Asn Gln Trp Lys 
865                 870                 875                 880 


Leu Asp Ser Glu Thr Val Pro Phe Glu Ile Arg Asn Lys Met Ile Gly 
                885                 890                 895     


Phe Trp Gln Met Leu His Glu Asn Gly Leu Met Ser Asn Lys Lys Phe 
            900                 905                 910         


Phe Ser Leu Ile Arg Thr Asp Phe Ser Asp Lys Asp Lys Glu Arg Phe 
        915                 920                 925             


Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys Asn Val Ala 
    930                 935                 940                 


Val Ile Ile Asn Asp His Tyr Thr Asn Thr Asn Ile Val Thr Val Arg 
945                 950                 955                 960 


Ala Glu Leu Ser His Gln Phe Arg Glu Arg Tyr Lys Ile Tyr Lys Asn 
                965                 970                 975     


Arg Asp Ile Asn Asp Phe His His Ala His Asp Ala Tyr Ile Ala Cys 
            980                 985                 990         


Ile Val Gly Gln Phe Met His Gln  Asn Phe Glu His Leu  Asp Ala Lys 
        995                 1000                 1005             


Ile Ile  Tyr Gly Gln Tyr Lys  Lys Asn Tyr Lys Lys  Asp Val Lys 
    1010                 1015                 1020             


His His  Asn Asn Tyr Gly Phe  Ile Leu Asn Ser Met  Asn His Leu 
    1025                 1030                 1035             


Gln Ser  Asp Ile Asp Thr Gly  Glu Val Met Trp Asp  Pro Ala Lys 
    1040                 1045                 1050             


Ile Gly  Lys Ile Lys Ser Cys  Phe Tyr Tyr Lys Asp  Val Tyr Val 
    1055                 1060                 1065             


Thr Lys  Lys Leu Glu Gln Asn  Ser Gly Thr Leu Phe  Asn Val Thr 
    1070                 1075                 1080             


Val Leu  Pro Asn Asp Ala His  Ser Glu Lys Gly Ile  Thr Ala Ala 
    1085                 1090                 1095             


Thr Val  Pro Leu Asn Lys Tyr  Arg Ala Asp Val His  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Phe  Gly Asn Val Gln Ser  Ile Ile Val Ala Ile  Glu Gly Lys 
    1115                 1120                 1125             


Lys Lys  Lys Gly Lys Lys Leu  Ile Asp Val Arg Lys  Leu Thr Ser 
    1130                 1135                 1140             


Ile Pro  Leu His Leu Lys Asn  Ala Pro Val Glu Glu  Gln Leu Ser 
    1145                 1150                 1155             


Tyr Ile  Ala Ser Pro Glu His  Glu Asp Leu Ile Asp  Val Arg Ile 
    1160                 1165                 1170             


Val Lys  Glu Ile Leu Lys Asn  Gln Leu Ile Glu Ile  Asp Gly Gly 
    1175                 1180                 1185             


Leu Tyr  Tyr Val Thr Ser Pro  Thr Glu Tyr Val Thr  Ala Arg Gln 
    1190                 1195                 1200             


Leu Ser  Leu Asn Glu Gln Ser  Cys Lys Leu Ile Ser  Glu Ile Tyr 
    1205                 1210                 1215             


Ala Ala  Met Leu Lys Lys Arg  Tyr Glu Tyr Leu Asp  Glu Glu Glu 
    1220                 1225                 1230             


Ile Phe  Asp Leu Tyr Leu Gln  Leu Leu Gln Lys Met  Asp Thr Leu 
    1235                 1240                 1245             


Tyr Pro  Ala Tyr Lys Gly Ile  Ala Lys Arg Phe Phe  Asp Arg Ala 
    1250                 1255                 1260             


Glu Asp  Phe Lys Asn Ile Asp  Val Val Glu Lys Cys  Asp Val Ile 
    1265                 1270                 1275             


Lys Gln  Ile Leu Ile Ile Met  His Ala Gly Pro Met  Asn Gly Asn 
    1280                 1285                 1290             


Ile Met  Tyr Asp Asp Phe Lys  Phe Thr Asn Arg Ile  Gly Arg Phe 
    1295                 1300                 1305             


Thr His  Lys Asn Ile Asp Leu  Asn Lys Thr Thr Phe  Ile Ser Thr 
    1310                 1315                 1320             


Ser Val  Thr Gly Leu Phe Ser  Lys Lys Tyr Lys Leu  
    1325                 1330                 1335 


<210>  546
<211>  1417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  546

Met Asp Tyr Lys Asp Asp Asp Asp Lys Asp Tyr Lys Asp Asp Asp Asp 
1               5                   10                  15      


Lys Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro 
            20                  25                  30          


Ala Ala Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
        35                  40                  45              


Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys 
    50                  55                  60                  


Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu 
65                  70                  75                  80  


Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
                85                  90                  95      


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile 
            100                 105                 110         


Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp 
        115                 120                 125             


Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys 
    130                 135                 140                 


Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala 
145                 150                 155                 160 


Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val 
                165                 170                 175     


Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
            180                 185                 190         


His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn 
        195                 200                 205             


Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr 
    210                 215                 220                 


Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp 
225                 230                 235                 240 


Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu 
                245                 250                 255     


Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly 
            260                 265                 270         


Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn 
        275                 280                 285             


Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr 
    290                 295                 300                 


Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala 
305                 310                 315                 320 


Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser 
                325                 330                 335     


Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala 
            340                 345                 350         


Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu 
        355                 360                 365             


Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe 
    370                 375                 380                 


Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala 
385                 390                 395                 400 


Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met 
                405                 410                 415     


Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu 
            420                 425                 430         


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
        435                 440                 445             


Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro 
    450                 455                 460                 


Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
465                 470                 475                 480 


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala 
                485                 490                 495     


Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu 
            500                 505                 510         


Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met 
        515                 520                 525             


Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His 
    530                 535                 540                 


Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
545                 550                 555                 560 


Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu 
                565                 570                 575     


Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val 
            580                 585                 590         


Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe 
        595                 600                 605             


Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu 
    610                 615                 620                 


Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu 
625                 630                 635                 640 


Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu 
                645                 650                 655     


Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr 
            660                 665                 670         


Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg 
        675                 680                 685             


Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg 
    690                 695                 700                 


Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly 
705                 710                 715                 720 


Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr 
                725                 730                 735     


Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser 
            740                 745                 750         


Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys 
        755                 760                 765             


Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met 
    770                 775                 780                 


Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
785                 790                 795                 800 


Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg 
                805                 810                 815     


Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His 
            820                 825                 830         


Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr 
        835                 840                 845             


Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn 
    850                 855                 860                 


Arg Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu 
865                 870                 875                 880 


Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn 
                885                 890                 895     


Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met 
            900                 905                 910         


Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg 
        915                 920                 925             


Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu 
    930                 935                 940                 


Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile 
945                 950                 955                 960 


Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr 
                965                 970                 975     


Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys 
            980                 985                 990         


Ser Lys Leu Val Ser Asp Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val 
        995                 1000                 1005             


Arg Glu  Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
    1010                 1015                 1020             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1025                 1030                 1035             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1040                 1045                 1050             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1055                 1060                 1065             


Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile 
    1070                 1075                 1080             


Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1085                 1090                 1095             


Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe 
    1100                 1105                 1110             


Ala Thr  Val Arg Lys Val Leu  Ser Met Pro Gln Val  Asn Ile Val 
    1115                 1120                 1125             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1130                 1135                 1140             


Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp 
    1145                 1150                 1155             


Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala 
    1160                 1165                 1170             


Tyr Ser  Val Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys 
    1175                 1180                 1185             


Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu 
    1190                 1195                 1200             


Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys 
    1205                 1210                 1215             


Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys 
    1220                 1225                 1230             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala 
    1235                 1240                 1245             


Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser 
    1250                 1255                 1260             


Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu 
    1265                 1270                 1275             


Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu 
    1280                 1285                 1290             


Gln His  Lys His Tyr Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu 
    1295                 1300                 1305             


Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val 
    1310                 1315                 1320             


Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln 
    1325                 1330                 1335             


Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala 
    1340                 1345                 1350             


Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg 
    1355                 1360                 1365             


Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala Thr Leu  Ile His Gln 
    1370                 1375                 1380             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1385                 1390                 1395             


Gly Gly  Asp Lys Arg Pro Ala  Ala Thr Lys Lys Ala  Gly Gln Ala 
    1400                 1405                 1410             


Lys Lys  Lys Lys 
    1415         


<210>  547
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  547

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  548
<211>  1376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  548

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Pro Pro  Lys Lys Lys Arg Lys  Val 
    1370                 1375     


<210>  549
<211>  1372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  549

Gly Ala Ala Ser Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
1               5                   10                  15      


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            20                  25                  30          


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        35                  40                  45              


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    50                  55                  60                  


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
65                  70                  75                  80  


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                85                  90                  95      


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            100                 105                 110         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        115                 120                 125             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    130                 135                 140                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
145                 150                 155                 160 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                165                 170                 175     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            180                 185                 190         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        195                 200                 205             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    210                 215                 220                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
225                 230                 235                 240 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                245                 250                 255     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            260                 265                 270         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        275                 280                 285             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    290                 295                 300                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
305                 310                 315                 320 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                325                 330                 335     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            340                 345                 350         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        355                 360                 365             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    370                 375                 380                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
385                 390                 395                 400 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                405                 410                 415     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            420                 425                 430         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        435                 440                 445             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    450                 455                 460                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
465                 470                 475                 480 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                485                 490                 495     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            500                 505                 510         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        515                 520                 525             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    530                 535                 540                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
545                 550                 555                 560 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                565                 570                 575     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            580                 585                 590         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        595                 600                 605             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    610                 615                 620                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
625                 630                 635                 640 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                645                 650                 655     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        675                 680                 685             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    690                 695                 700                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
705                 710                 715                 720 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            740                 745                 750         


Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala 
        755                 760                 765             


Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg 
    770                 775                 780                 


Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu 
785                 790                 795                 800 


Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr 
                805                 810                 815     


Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu 
            820                 825                 830         


Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln 
        835                 840                 845             


Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser 
    850                 855                 860                 


Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val 
865                 870                 875                 880 


Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile 
                885                 890                 895     


Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu 
            900                 905                 910         


Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr 
        915                 920                 925             


Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn 
    930                 935                 940                 


Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile 
945                 950                 955                 960 


Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe 
                965                 970                 975     


Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr 
            980                 985                 990         


Leu Asn Ala Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
        995                 1000                 1005             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1010                 1015                 1020             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1025                 1030                 1035             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1040                 1045                 1050             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1055                 1060                 1065             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1070                 1075                 1080             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1085                 1090                 1095             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1100                 1105                 1110             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1115                 1120                 1125             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1130                 1135                 1140             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1145                 1150                 1155             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1160                 1165                 1170             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1175                 1180                 1185             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1190                 1195                 1200             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1205                 1210                 1215             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1220                 1225                 1230             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1235                 1240                 1245             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1250                 1255                 1260             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1265                 1270                 1275             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1280                 1285                 1290             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1295                 1300                 1305             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1310                 1315                 1320             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1325                 1330                 1335             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1340                 1345                 1350             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1355                 1360                 1365             


Leu Gly  Gly Asp 
    1370         


<210>  550
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  550

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Glu 
    130                 135                 140                 


Asn Arg Gln Gly Leu Glu Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  551
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  551

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Ala Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  552
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  552

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Ala Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
    50                  55                  60                  


Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro 
                85                  90                  95      


Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val 
        115                 120                 125             


Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp 
            180                 185                 190         


Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  553
<211>  1803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  553

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys 
        115                 120                 125             


Arg Gly Ala Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ser Lys Arg Gly Ala Ala Gly Ser Leu Met Asn Val 
                325                 330                 335     


Leu Asn Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Asp Phe Tyr Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Ile Asn Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp 
                405                 410                 415     


Lys Lys Tyr Ser Ile Gly Leu Thr Ile Gly Thr Asn Ser Val Gly Trp 
            420                 425                 430         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        435                 440                 445             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    450                 455                 460                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
465                 470                 475                 480 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                485                 490                 495     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            500                 505                 510         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        515                 520                 525             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    530                 535                 540                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
545                 550                 555                 560 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                565                 570                 575     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            580                 585                 590         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        595                 600                 605             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    610                 615                 620                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
625                 630                 635                 640 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                645                 650                 655     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            660                 665                 670         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        675                 680                 685             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    690                 695                 700                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
705                 710                 715                 720 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Val 
                725                 730                 735     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            740                 745                 750         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        755                 760                 765             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    770                 775                 780                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
785                 790                 795                 800 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                805                 810                 815     


Arg Thr Phe Asp Asn Gly Ile Ile Pro His Gln Ile His Leu Gly Glu 
            820                 825                 830         


Leu His Ala Ile Leu Arg Arg Gln Gly Asp Phe Tyr Pro Phe Leu Lys 
        835                 840                 845             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    850                 855                 860                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
865                 870                 875                 880 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                885                 890                 895     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            900                 905                 910         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        915                 920                 925             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    930                 935                 940                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
945                 950                 955                 960 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                965                 970                 975     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            980                 985                 990         


Glu Ile Ser Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
        995                 1000                 1005             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1010                 1015                 1020             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1025                 1030                 1035             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1040                 1045                 1050             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Leu 
    1055                 1060                 1065             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1070                 1075                 1080             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1085                 1090                 1095             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1100                 1105                 1110             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1115                 1120                 1125             


Cys Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1130                 1135                 1140             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1145                 1150                 1155             


Asp Glu  Leu Val Lys Val Met  Gly Gly His Lys Pro  Glu Asn Ile 
    1160                 1165                 1170             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1175                 1180                 1185             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1190                 1195                 1200             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1205                 1210                 1215             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1220                 1225                 1230             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1235                 1240                 1245             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1250                 1255                 1260             


Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1265                 1270                 1275             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1280                 1285                 1290             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1295                 1300                 1305             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1310                 1315                 1320             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr 
    1325                 1330                 1335             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1340                 1345                 1350             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1355                 1360                 1365             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1370                 1375                 1380             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1385                 1390                 1395             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1400                 1405                 1410             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1415                 1420                 1425             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1430                 1435                 1440             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1445                 1450                 1455             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1460                 1465                 1470             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1475                 1480                 1485             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1490                 1495                 1500             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1505                 1510                 1515             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1520                 1525                 1530             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1535                 1540                 1545             


Asn Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1550                 1555                 1560             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1565                 1570                 1575             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1580                 1585                 1590             


Gly Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1595                 1600                 1605             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1610                 1615                 1620             


Arg Lys  Arg Met Leu Ala Ser  Ala Ser Val Leu His  Lys Gly Asn 
    1625                 1630                 1635             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1640                 1645                 1650             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Ser Glu Asp  Asn Lys Gln 
    1655                 1660                 1665             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1670                 1675                 1680             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1685                 1690                 1695             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1700                 1705                 1710             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1715                 1720                 1725             


Leu Thr  Asn Leu Gly Ala Ser  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1730                 1735                 1740             


Thr Ile  Gly Arg Lys Leu Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1745                 1750                 1755             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1760                 1765                 1770             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Ser Gly Gly  Ser Lys Arg 
    1775                 1780                 1785             


Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    1790                 1795                 1800             


<210>  554
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  554

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Arg Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Val  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Arg 
    1205                 1210                 1215             


Phe Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Arg Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Val  Tyr Arg Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  555
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  555

Met Gly Lys Arg Asn Tyr Ile Leu Gly Leu Ala Ile Gly Ile Thr Ser 
1               5                   10                  15      


Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala 
            20                  25                  30          


Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg 
        35                  40                  45              


Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg 
    50                  55                  60                  


Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp 
65                  70                  75                  80  


His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly 
                85                  90                  95      


Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His 
            100                 105                 110         


Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp 
        115                 120                 125             


Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys 
    130                 135                 140                 


Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys 
145                 150                 155                 160 


Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp 
                165                 170                 175     


Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His 
            180                 185                 190         


Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr 
        195                 200                 205             


Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp 
    210                 215                 220                 


Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr 
225                 230                 235                 240 


Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu 
                245                 250                 255     


Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu 
            260                 265                 270         


Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val 
        275                 280                 285             


Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile 
    290                 295                 300                 


Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly 
305                 310                 315                 320 


Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile 
                325                 330                 335     


Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile 
            340                 345                 350         


Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu 
        355                 360                 365             


Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile 
    370                 375                 380                 


Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala 
385                 390                 395                 400 


Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile 
                405                 410                 415     


Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser 
            420                 425                 430         


Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser 
        435                 440                 445             


Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala 
    450                 455                 460                 


Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala 
465                 470                 475                 480 


Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln 
                485                 490                 495     


Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr 
            500                 505                 510         


Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His 
        515                 520                 525             


Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu 
    530                 535                 540                 


Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile 
545                 550                 555                 560 


Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val 
                565                 570                 575     


Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr 
            580                 585                 590         


Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His 
        595                 600                 605             


Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys 
    610                 615                 620                 


Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys 
625                 630                 635                 640 


Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly 
                645                 650                 655     


Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val 
            660                 665                 670         


Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys 
        675                 680                 685             


Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu 
    690                 695                 700                 


Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys 
705                 710                 715                 720 


Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu 
                725                 730                 735     


Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys 
            740                 745                 750         


Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys 
        755                 760                 765             


Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Lys Leu 
    770                 775                 780                 


Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr 
785                 790                 795                 800 


Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys 
                805                 810                 815     


Leu Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His 
            820                 825                 830         


His Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr 
        835                 840                 845             


Gly Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn 
    850                 855                 860                 


Tyr Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys 
865                 870                 875                 880 


Ile Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp 
                885                 890                 895     


Asp Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro 
            900                 905                 910         


Tyr Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr 
        915                 920                 925             


Val Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn 
    930                 935                 940                 


Ser Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln 
945                 950                 955                 960 


Ala Glu Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Ile Asn 
                965                 970                 975     


Gly Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg 
            980                 985                 990         


Ile Glu Val Asn Met Ile Asp Ile  Thr Tyr Arg Glu Tyr  Leu Glu Asn 
        995                 1000                 1005             


Met Asn  Asp Lys Arg Pro Pro  His Ile Ile Lys Thr  Ile Ala Ser 
    1010                 1015                 1020             


Lys Thr  Gln Ser Ile Lys Lys  Tyr Ser Thr Asp Ile  Leu Gly Asn 
    1025                 1030                 1035             


Leu Tyr  Glu Val Lys Ser Lys  Lys His Pro Gln Ile  Ile Lys Lys 
    1040                 1045                 1050             


Gly 
    


<210>  556
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  556

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Thr Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Leu Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ile Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Lys 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Asp Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Ile Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Val Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  557
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (5)..(124)
<223>  may be absent

<400>  557

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
1               5                   10                  15      


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
        35                  40                  45              


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
    50                  55                  60                  


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
65                  70                  75                  80  


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
                85                  90                  95      


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            100                 105                 110         


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
        115                 120                 


<210>  558
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (5)..(124)
<223>  may be absent

<400>  558

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    50                  55                  60                  


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        115                 120                 


<210>  559
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (6)..(155)
<223>  may be absent

<400>  559

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155 


<210>  560
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (6)..(155)
<223>  may be absent

<400>  560

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
        35                  40                  45              


Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
    50                  55                  60                  


Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
                85                  90                  95      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
            100                 105                 110         


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
        115                 120                 125             


Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
    130                 135                 140                 


Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
145                 150                 155 


<210>  561
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  561

Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 
1               5                   10                  15      


Thr Pro Glu Ser Ser Gly Gly Ser 
            20                  


<210>  562
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(93)
<223>  may be absent

<400>  562

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        35                  40                  45              


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    50                  55                  60                  


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
65                  70                  75                  80  


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                85                  90              


<210>  563
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(62)
<223>  may be absent

<400>  563

Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro 
1               5                   10                  15      


Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro 
            20                  25                  30          


Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro 
        35                  40                  45              


Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro 
    50                  55                  60          


<210>  564
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  564

Gly Gly Ser Gly Gly Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
1               5                   10                  15      


Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
            20                  25                  30          


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 
        35                  40                  45              


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 
    50                  55                  60                  


Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
65                  70                  75                  80  


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
                85                  90                  95      


Thr Ser Gly Gly Ser Gly Gly Ser 
            100                 


<210>  565
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  565
guuuuaguac ucuguaauga aaauuacaga aucuacuaaa acaaggcaaa augccguguu       60

uaucucguca acuuguuggc gagauuuuuu u                                      91


<210>  566
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  566
uaauuucuac uaaguguaga u                                                 21


<210>  567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  567
uaauuucuac ucuuguagau                                                   20


<210>  568
<211>  97
<212>  RNA
<213>  S. thermophilus

<400>  568
guuuuagagc uguguuguuu guuaaaacaa cacagcgagu uaaaauaagg cuuaguccgu       60

acucaacuug aaaagguggc accgauucgg uguuuuu                                97


<210>  569
<211>  95
<212>  RNA
<213>  F. novicida

<400>  569
aucuaaaauu auaaauguac caaauaauua augcucugua aucauuuaaa aguauuuuga       60

acggaccucu guuugacacg ucugaauaac uaaaa                                  95


<210>  570
<211>  109
<212>  RNA
<213>  S. thermophilus

<400>  570
uguaagggac gccuuacaca guuacuuaaa ucuugcagaa gcuacaaaga uaaggcuuca       60

ugccgaaauc aacacccugu cauuuuaugg caggguguuu ucguuauuu                  109


<210>  571
<211>  92
<212>  RNA
<213>  L. innocua

<400>  571
auuguuagua uucaaaauaa cauagcaagu uaaaauaagg cuuuguccgu uaucaacuuu       60

uaauuaagua gcgcuguuuc ggcgcuuuuu uu                                     92


<210>  572
<211>  107
<212>  RNA
<213>  S. mutans

<400>  572
guuggaauca uucgaaacaa cacagcaagu uaaaauaagg cagugauuuu uaauccaguc       60

cguacacaac uugaaaaagu gcgcaccgau ucggugcuuu uuuauuu                    107


<210>  573
<211>  96
<212>  RNA
<213>  S. thermophilus

<400>  573
uugugguuug aaaccauucg aaacaacaca gcgaguuaaa auaaggcuua guccguacuc       60

aacuugaaaa gguggcaccg auucgguguu uuuuuu                                 96


<210>  574
<211>  102
<212>  RNA
<213>  N. meningitidis

<400>  574
acauauuguc gcacugcgaa augagaaccg uugcuacaau aaggccgucu gaaaagaugu       60

gccgcaacgc ucugccccuu aaagcuucug cuuuaagggg ca                         102


<210>  575
<211>  110
<212>  RNA
<213>  P. multocida

<400>  575
gcauauuguu gcacugcgaa augagagacg uugcuacaau aaggcuucug aaaagaauga       60

ccguaacgcu cugccccuug ugauucuuaa uugcaagggg caucguuuuu                 110


<210>  576
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  576
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcct                                            145


<210>  577
<211>  146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  577
ttggccactc cctctatgcg cactcgctcg ctcggtgggg cctggcgacc aaaggtcgcc       60

agacggacgt gctttgcacg tccggcccca ccgagcgagc gagtgcgcat agagggagtg      120

gccaactcca tcactagagg tatggc                                           146


<210>  578
<211>  167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  578
ctctcccccc tgtcgcgttc gctcgctcgc tggctcgttt gggggggtgg cagctcaaag       60

agctgccaga cgacggccct ctggccgtcg cccccccaaa cgagccagcg agcgagcgaa      120

cgcgacaggg gggagagtgc cacactctca agcaaggggg ttttgta                    167


<210>  579
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  579
tggagttcag acgtgtgctc ttccgatctc ccttattgga agtcagggct ta               52


<210>  580
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  580
acactctttc cctacacgac gctcttccga tctnnnngga ggatcactaa gagaaggct        59


<210>  581
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  581
acactctttc cctacacgac gctcttccga tctnnnnaat gaaggcgctc ttgggaa          57


<210>  582
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  582
tggagttcag acgtgtgctc ttccgatctc gtacggtaaa ccccagagg                   49


<210>  583
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  583
acactctttc cctacacgac gctcttccga tctnnnnggt gtccgcctgg ctc              53


<210>  584
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  584
tggagttcag acgtgtgctc ttccgatctc acctgtcctc tggtctgga                   49


<210>  585
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  585
acactctttc cctacacgac gctcttccga tctnnnnaca aaagaagggg gagcgac          57


<210>  586
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  586
tggagttcag acgtgtgctc ttccgatctt gcacagcata aaagggtgc                   49


<210>  587
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  587
acactctttc cctacacgac gctcttccga tctnnnnggc aaggggcatc cttatgt          57


<210>  588
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  588

Arg Leu Thr Ala Ser Asn Ile Thr Glu Thr 
1               5                   10  


<210>  589
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  589

Arg Leu Ile Ala Ser Asn Ile Thr Glu Thr 
1               5                   10  


<210>  590
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  590
cggctaacag ccagtaacat cacggaaacc                                        30


<210>  591
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  591
cggctaatag ccagtaacat cacggaaacc                                        30


<210>  592
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  592
gatgttccaa tcagta                                                       16


<210>  593
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  593
tctgcttctc cagccc                                                       16


<210>  594
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  594
acgtgctcag tctggg                                                       16


<210>  595
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  595
gcgaggcaga gggtcc                                                       16


<210>  596
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  596
ccactgtagt cacaca                                                       16


<210>  597
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  597
gtggcactgc ggctgg                                                       16


<210>  598
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  598
caccgcgggc tggagctgtt cgcgc                                             25


<210>  599
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  599
aaacgcgcga acagctccag cccgc                                             25


<210>  600
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  600
caccgctaac agccagtaac atca                                              24


<210>  601
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  601
aaactgatgt tactggctgt tagc                                              24


<210>  602
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  602
caccgaacag ctctgaacga gaccc                                             25


<210>  603
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  603
aaacgggtct cgttcagagc tgttc                                             25


<210>  604
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  604
caccgccacc gcagccacgc agagca                                            26


<210>  605
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  605
aaactgctct gcgtggctgc ggtggc                                            26


<210>  606
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  606
acactctttc cctacacgac gctcttccga tctnnnncct tcgggcatag catggtc          57


<210>  607
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  607
tggagttcag acgtgtgctc ttccgatctt atatgcctcg gcatcggtcc                  50


<210>  608
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  608
acactctttc cctacacgac gctcttccga tctnnnnggg gacatgctgc ttacggtt         58


<210>  609
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  609
tggagttcag acgtgtgctc ttccgatctt ggcccgctca cctcaaatgc                  50


<210>  610
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  610
acactctttc cctacacgac gctcttccga tctnnnngcc ggggtctcgt tcagagct         58


<210>  611
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  611
tggagttcag acgtgtgctc ttccgatctc taccgcctgc ggacatggt                   49


<210>  612
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  612
acactctttc cctacacgac gctcttccga tctnnnncag ctcagcctga gtgttga          57


<210>  613
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  613
tggagttcag acgtgtgctc ttccgatctc tcgtgggttt gtggttgc                    48


<210>  614
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  614
acactctttc cctacacgac gctcttccga tctnnnncat tgcagagagg cgtatca          57


<210>  615
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  615
tggagttcag acgtgtgctc ttccgatctg gggtcccagg tgctgac                     47


<210>  616
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  616
acactctttc cctacacgac gctcttccga tctnnnncca gccccatctg tcaaact          57


<210>  617
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  617
tggagttcag acgtgtgctc ttccgatctt gaatggattc cttggaaaca atga             54


<210>  618
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  618
acactctttc cctacacgac gctcttccga tctnnnnatg tgggctgcct agaaagg          57


<210>  619
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  619
tggagttcag acgtgtgctc ttccgatctc ccagccaaac ttgtcaacc                   49


<210>  620
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  620
acactctttc cctacacgac gctcttccga tctnnnngaa cccaggtagc cagagac          57


<210>  621
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  621
tggagttcag acgtgtgctc ttccgatctt cctttcaacc cgaacggag                   49


<210>  622
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  622
acactctttc cctacacgac gctcttccga tctnnnnacg tctcatatgc cccttgg          57


<210>  623
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  623
tggagttcag acgtgtgctc ttccgatcta cgtaggaatt ttggtgggac a                51


<210>  624
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  624
acactctttc cctacacgac gctcttccga tctnnnnggc gtccatgtcc ttcccga          57


<210>  625
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  625
tggagttcag acgtgtgctc ttccgatcta catgtgcggc ctcatcagcc a                51


<210>  626
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  626
acactctttc cctacacgac gctcttccga tctnnnnaga acaatgggga tggggaggtt       60


<210>  627
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  627
tggagttcag acgtgtgctc ttccgatctc tcagtggcct cgtacttcct                  50


<210>  628
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  628
acactctttc cctacacgac gctcttccga tctnnnnggc agggcttcca gtcctcatt        59


<210>  629
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  629
tggagttcag acgtgtgctc ttccgatctg tgctcattct gggctctttt tggc             54


<210>  630
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  630
acactctttc cctacacgac gctcttccga tctnnnnccc ggccccacct atactcaaa        59


<210>  631
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  631
tggagttcag acgtgtgctc ttccgatctg cttgctgcgc tagccttcat                  50


<210>  632
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  632
acactctttc cctacacgac gctcttccga tctnnnncta cccagggaga ttcatgc          57


<210>  633
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  633
tggagttcag acgtgtgctc ttccgatctt ggactgaacc tctgaacctg                  50


<210>  634
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  634
acactctttc cctacacgac gctcttccga tctnnnntgc acactctgtg gagaactggt       60


<210>  635
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  635
tggagttcag acgtgtgctc ttccgatcta gtgtgtccat gtgatttgaa tgct             54


<210>  636
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  636
acactctttc cctacacgac gctcttccga tctnnnnggc cagccttcat ccttggc          57


<210>  637
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  637
tggagttcag acgtgtgctc ttccgatctt gcgtggctag gtgggcttt                   49


<210>  638
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  638
acactctttc cctacacgac gctcttccga tctnnnntct gcaacctgtg ggctcaaga        59


<210>  639
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  639
tggagttcag acgtgtgctc ttccgatcta gtcagatctc tccaggggtc at               52


<210>  640
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<400>  640
acactctttc cctacacgac gctcttccga tctnnnnagg tttgctgcgg tattttca         58


<210>  641
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  641
tggagttcag acgtgtgctc ttccgatctt gtgtagtgaa gaaatggaaa cct              53


<210>  642
<211>  5020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  642
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagaaggt cgggcaggaa gagggcctat ttcccatgat      240

tccttcatat ttgcatatac gatacaaggc tgttagagag ataattagaa ttaatttgac      300

tgtaaacaca aagatattag tacaaaatac gtgacgtaga aagtaataat ttcttgggta      360

gtttgcagtt ttaaaattat gttttaaaat ggactatcat atgcttaccg taacttgaaa      420

gtatttcgat ttcttggctt tatatatctt gtggaaagga cgaaacaccc gagacgatta      480

atgcgtctcg gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac      540

ttgaaaaagt ggcaccgagt cggtgctttt tttgctagcg gtacccgtta cataacttac      600

ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caatagtaac      660

gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt      720

ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa      780

atggcccgcc tggcattgtg cccagtacat gaccttatgg gactttccta cttggcagta      840

catctacgta ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac      900

tctccccatc tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt      960

ttgtgcagcg atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg     1020

cgaggggcgg ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct     1080

ccgaaagttt ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc     1140

gcggcgggcg ggagtcgctg cgacgctgcc ttcgccccgt gccccgctcc gccgccgcct     1200

cgcgccgccc gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg     1260

gcccttctcc tccgggctgt aattagctga gcaagaggta agggtttaag ggatggttgg     1320

ttggtggggt attaatgttt aattacctgg agcacctgcc tgaaatcact ttttttcagg     1380

ttggaccggt gccaccatga agaggactgc cgatggatca gagtttgaat ctcccaagaa     1440

gaagaggaaa gtaagctcag agactggccc agtggctgtg gaccccacat taagacggcg     1500

gatcgagccc catgagtttg aggtattctt cgatccgaga gagctccgca aggagacctg     1560

cctgctttac gaaattaatt gggggggccg gcactccatt tggcgacata catcacagaa     1620

cactaacaag cacgtcgaag tcaacttcat cgagaagttc acgacagaaa gatatttctg     1680

tccgaacaca aggtgcagca ttacctggtt tctcagctgg agcccatgcg gcgaatgtag     1740

tagggccatc actgaattcc tgtcaaggta tccccacgtc actctgttta tttacatcgc     1800

aaggctgtac caccacgctg acccccgcaa tcgacaaggc ctgcgggatt tgatctcttc     1860

aggtgtgact atccaaatta tgactgagca ggagtcagga tactgctgga gaaactttgt     1920

gaattatagc ccgagtaatg aagcccactg gcctaggtat ccccatctgt gggtacgact     1980

gtacgttctt gaactgtact gcatcatact gggcctgcct ccttgtctca acattctgag     2040

aaggaagcag ccacagctga cattctttac catcgctctt cagtcttgtc attaccagcg     2100

actgccccca cacattctct gggccaccgg gttgaaatct ggtggttctt ctggtggttc     2160

tagcggcagc gagactcccg ggacctcaga gtccgccaca cccgaaagtt ctggtggttc     2220

ttctggtggt tctgataaaa agtattctat tggtttagcc atcggcacta attccgttgg     2280

atgggctgtc ataaccgatg aatacaaagt accttcaaag aaatttaagg tgttggggaa     2340

cacagaccgt cattcgatta aaaagaatct tatcggtgcc ctcctattcg atagtggcga     2400

aacggcagag gcgactcgcc tgaaacgaac cgctcggaga aggtatacac gtcgcaagaa     2460

ccgaatatgt tacttacaag aaatttttag caatgagatg gccaaagttg acgattcttt     2520

ctttcaccgt ttggaagagt ccttccttgt cgaagaggac aagaaacatg aacggcaccc     2580

catctttgga aacatagtag atgaggtggc atatcatgaa aagtacccaa cgatttatca     2640

cctcagaaaa aagctagttg actcaactga taaagcggac ctgaggttaa tctacttggc     2700

tcttgcccat atgataaagt tccgtgggca ctttctcatt gagggtgatc taaatccgga     2760

caactcggat gtcgacaaac tgttcatcca gttagtacaa acctataatc agttgtttga     2820

agagaaccct ataaatgcaa gtggcgtgga tgcgaaggct attcttagcg cccgcctctc     2880

taaatcccga cggctagaaa acctgatcgc acaattaccc ggagagaaga aaaatgggtt     2940

gttcggtaac cttatagcgc tctcactagg cctgacacca aattttaagt cgaacttcga     3000

cttagctgaa gatgccaaat tgcagcttag taaggacacg tacgatgacg atctcgacaa     3060

tctactggca caaattggag atcagtatgc ggacttattt ttggctgcca aaaaccttag     3120

cgatgcaatc ctcctatctg acatactgag agttaatact gagattacca aggcgccgtt     3180

atccgcttca atgatcaaaa ggtacgatga acatcaccaa gacttgacac ttctcaaggc     3240

cctagtccgt cagcaactgc ctgagaaata taaggaaata ttctttgatc agtcgaaaaa     3300

cgggtacgca ggttatattg acggcggagc gagtcaagag gaattctaca agtttatcaa     3360

acccatatta gagaagatgg atgggacgga agagttgctt gtaaaactca atcgcgaaga     3420

tctactgcga aagcagcgga ctttcgacaa cggtagcatt ccacatcaaa tccacttagg     3480

cgaattgcat gctatactta gaaggcagga ggatttttat ccgttcctca aagacaatcg     3540

tgaaaagatt gagaaaatcc taacctttcg cataccttac tatgtgggac ccctggcccg     3600

agggaactct cggttcgcat ggatgacaag aaagtccgaa gaaacgatta ctccatggaa     3660

ttttgaggaa gttgtcgata aaggtgcgtc agctcaatcg ttcatcgaga ggatgaccaa     3720

ctttgacaag aatttaccga acgaaaaagt attgcctaag cacagtttac tttacgagta     3780

tttcacagtg tacaatgaac tcacgaaagt taagtatgtc actgagggca tgcgtaaacc     3840

cgcctttcta agcggagaac agaagaaagc aatagtagat ctgttattca agaccaaccg     3900

caaagtgaca gttaagcaat tgaaagagga ctactttaag aaaattgaat gcctgtcata     3960

cgaaaccgag atactgacag tagaatatgg ccttctgcca atcgggaaga ttgtggagaa     4020

acggatagaa tgcacagttt actctgtcga taacaatggt aacatttata ctcagccagt     4080

tgcccagtgg cacgaccggg gagagcagga agtattcgaa tactgtctgg aggatggaag     4140

tctcattagg gccactaagg accacaaatt tatgacagtc gatggccaga tgctgcctat     4200

agacgaaatc tttgagcgag agttggacct catgcgagtt gacaaccttc ctaattctgg     4260

tggttctaaa agaaccgccg acggcagcga attcgagccc aagaagaaga ggaaagtcta     4320

agatctgata atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac     4380

tatgttgctc cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt     4440

gcttcccgta tggctttcat tttctcctcc ttgtataaat cctggttagt tcttgccacg     4500

gcggaactca tcgccgcctg ccttgcccgc tgctggacag gggctcggct gttgggcact     4560

gacaattccg tggtgcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc     4620

ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg     4680

aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg     4740

acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta     4800

tggctcgagt taagggcgaa ttcccgataa ggatcttcct agagcatggc tacgtagata     4860

agtagcatgg cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc     4920

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     4980

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag                           5020


<210>  643
<211>  4987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  643
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagaaggt cgggcaggaa gagggcctat ttcccatgat      240

tccttcatat ttgcatatac gatacaaggc tgttagagag ataattagaa ttaatttgac      300

tgtaaacaca aagatattag tacaaaatac gtgacgtaga aagtaataat ttcttgggta      360

gtttgcagtt ttaaaattat gttttaaaat ggactatcat atgcttaccg taacttgaaa      420

gtatttcgat ttcttggctt tatatatctt gtggaaagga cgaaacaccc gagacgatta      480

atgcgtctcg gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac      540

ttgaaaaagt ggcaccgagt cggtgctttt tttgctagcg gtacccgtta cataacttac      600

ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caatagtaac      660

gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt      720

ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa      780

atggcccgcc tggcattgtg cccagtacat gaccttatgg gactttccta cttggcagta      840

catctacgta ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac      900

tctccccatc tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt      960

ttgtgcagcg atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg     1020

cgaggggcgg ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct     1080

ccgaaagttt ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc     1140

gcggcgggcg ggagtcgctg cgacgctgcc ttcgccccgt gccccgctcc gccgccgcct     1200

cgcgccgccc gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg     1260

gcccttctcc tccgggctgt aattagctga gcaagaggta agggtttaag ggatggttgg     1320

ttggtggggt attaatgttt aattacctgg agcacctgcc tgaaatcact ttttttcagg     1380

ttggaccggt gccaccatga agaggactgc cgatggatca gagtttgaat ctcccaagaa     1440

gaagaggaaa gtaatcaaga tagctacaag gaagtatctt ggcaaacaaa acgtttatga     1500

tattggagtc gaaagagatc acaactttgc tctgaagaac ggattcatag cttctaattg     1560

cttcgattct gtcgagatct ccggggtaga agatcgattt aatgcgtcac ttggtacgta     1620

tcatgacctc ctaaagataa ttaaagataa ggacttcctg gataacgaag agaatgaaga     1680

tatcttagaa gatatagtgt tgactcttac cctctttgaa gatcgggaaa tgattgagga     1740

aagactaaaa acatacgctc acctgttcga cgataaggtt atgaaacagt taaagaggcg     1800

tcgctatacg ggctggggac gattgtcgcg gaaacttatc aacgggataa gagacaagca     1860

aagtggtaaa actattctcg attttctaaa gagcgacggc ttcgccaata ggaactttat     1920

gcagctgatc catgatgact ctttaacctt caaagaggat atacaaaagg cacaggtttc     1980

cggacaaggg gactcattgc acgaacatat tgcgaatctt gctggttcgc cagccatcaa     2040

aaagggcata ctccagacag tcaaagtagt ggatgagcta gttaaggtca tgggacgtca     2100

caaaccggaa aacattgtaa tcgagatggc acgcgaaaat caaacgactc agaaggggca     2160

aaaaaacagt cgagagcgga tgaagagaat agaagagggt attaaagaac tgggcagcca     2220

gatcttaaag gagcatcctg tggaaaatac ccaattgcag aacgagaaac tttacctcta     2280

ttacctacaa aatggaaggg acatgtatgt tgatcaggaa ctggacataa accgtttatc     2340

tgattacgac gtcgatcaca ttgtacccca atcctttttg aaggacgatt caatcgacaa     2400

taaagtgctt acacgctcgg ataagaaccg agggaaaagt gacaatgttc caagcgagga     2460

agtcgtaaag aaaatgaaga actattggcg gcagctccta aatgcgaaac tgataacgca     2520

aagaaagttc gataacttaa ctaaagctga gaggggtggc ttgtctgaac ttgacaaggc     2580

cggatttatt aaacgtcagc tcgtggaaac ccgccaaatc acaaagcatg ttgcacagat     2640

actagattcc cgaatgaata cgaaatacga cgagaacgat aagctgattc gggaagtcaa     2700

agtaatcact ttaaagtcaa aattggtgtc ggacttcaga aaggattttc aattctataa     2760

agttagggag ataaataact accaccatgc gcacgacgct tatcttaatg ccgtcgtagg     2820

gaccgcactc attaagaaat acccgaagct agaaagtgag tttgtgtatg gtgattacaa     2880

agtttatgac gtccgtaaga tgatcgcgaa aagcgaacag gagataggca aggctacagc     2940

caaatacttc ttttattcta acattatgaa tttctttaag acggaaatca ctctggcaaa     3000

cggagagata cgcaaacgac ctttaattga aaccaatggg gagacaggtg aaatcgtatg     3060

ggataagggc cgggacttcg cgacggtgag aaaagttttg tccatgcccc aagtcaacat     3120

agtaaagaaa actgaggtgc agaccggagg gttttcaaag gaatcgattc ttccaaaaag     3180

gaatagtgat aagctcatcg ctcgtaaaaa ggactgggac ccgaaaaagt acggtggctt     3240

cgatagccct acagttgcct attctgtcct agtagtggca aaagttgaga agggaaaatc     3300

caagaaactg aagtcagtca aagaattatt ggggataacg attatggagc gctcgtcttt     3360

tgaaaagaac cccatcgact tccttgaggc gaaaggttac aaggaagtaa aaaaggatct     3420

cataattaaa ctaccaaagt atagtctgtt tgagttagaa aatggccgaa aacggatgtt     3480

ggctagcgcc ggagagcttc aaaaggggaa cgaactcgca ctaccgtcta aatacgtgaa     3540

tttcctgtat ttagcgtccc attacgagaa gttgaaaggt tcacctgaag ataacgaaca     3600

gaagcaactt tttgttgagc agcacaaaca ttatctcgac gaaatcatag agcaaatttc     3660

ggaattcagt aagagagtca tcctagctga tgccaatctg gacaaagtat taagcgcata     3720

caacaagcac agggataaac ccatacgtga gcaggcggaa aatattatcc atttgtttac     3780

tcttaccaac ctcggcgctc cagccgcatt caagtatttt gacacaacga tagatcgcaa     3840

acgatacact tctaccaagg aggtgctaga cgcgacactg attcaccaat ccatcacggg     3900

attatatgaa actcggatag atttgtcaca gcttgggggt gactctggtg gttctggagg     3960

atctggtggt tctactaatc tgtcagatat tattgaaaag gagaccggta agcaactggt     4020

tatccaggaa tccatcctca tgctcccaga ggaggtggaa gaagtcattg ggaacaagcc     4080

ggaaagcgat atactcgtgc acaccgccta cgacgagagc accgacgaga atgtcatgct     4140

tctgactagc gacgcccctg aatacaagcc ttgggctctg gtcatacagg atagcaacgg     4200

tgagaacaag attaagatgc tctctggtgg ttctaaaaga accgccgacg gcagcgaatt     4260

cgagcccaag aagaagagga aagtctaaga tctgataatc aacctctgga ttacaaaatt     4320

tgtgaaagat tgactggtat tcttaactat gttgctcctt ttacgctatg tggatacgct     4380

gctttaatgc ctttgtatca tgctattgct tcccgtatgg ctttcatttt ctcctccttg     4440

tataaatcct ggttagttct tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc     4500

tggacagggg ctcggctgtt gggcactgac aattccgtgg tgcgactgtg ccttctagtt     4560

gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc     4620

ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt     4680

ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca     4740

ggcatgctgg ggatgcggtg ggctctatgg ctcgagttaa gggcgaattc ccgataagga     4800

tcttcctaga gcatggctac gtagataagt agcatggcgg gttaatcatt aactacaagg     4860

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg     4920

ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag     4980

cgcgcag                                                               4987


<210>  644
<211>  4830
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  644
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggcctcta gactcgagaa ggtcgggcag gaagagggcc tatttcccat      180

gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta gaattaattt      240

gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat aatttcttgg      300

gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta ccgtaacttg      360

aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca cccgagacga      420

ttaatgcgtc tcggttttag agctagaaat agcaagttaa aataaggcta gtccgttatc      480

aacttgaaaa agtggcaccg agtcggtgct ttttttgcta gcggtacccg ttacataact      540

tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaatagt      600

aacgccaata gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca      660

cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg      720

taaatggccc gcctggcatt gtgcccagta catgacctta tgggactttc ctacttggca      780

gtacatctac gtattagtca tcgctattac catggtcgag gtgagcccca cgttctgctt      840

cactctcccc atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt      900

attttgtgca gcgatggggg cggggggggg gggggggcgc gcgccaggcg gggcggggcg      960

gggcgagggg cggggcgggg cgaggcggag aggtgcggcg gcagccaatc agagcggcgc     1020

gctccgaaag tttcctttta tggcgaggcg gcggcggcgg cggccctata aaaagcgaag     1080

cgcgcggcgg gcgggagtcg ctgcgacgct gccttcgccc cgtgccccgc tccgccgccg     1140

cctcgcgccg cccgccccgg ctctgactga ccgcgttact cccacaggtg agcgggcggg     1200

acggcccttc tcctccgggc tgtaattagc tgagcaagag gtaagggttt aagggatggt     1260

tggttggtgg ggtattaatg tttaattacc tggagcacct gcctgaaatc actttttttc     1320

aggttggacc ggtgccacca tgtcctcaga gactgggcct gtcgccgtcg atccaaccct     1380

gcgccgccgg attgaacctc acgagtttga agtgttcttt gacccccggg agctgagaaa     1440

ggagacatgc ctgctgtacg agatcaactg gggaggcagg cactccatct ggaggcacac     1500

ctctcagaac acaaataagc acgtggaggt gaacttcatc gagaagttta ccacagagcg     1560

gtacttctgc cccaatacca gatgtagcat cacatggttt ctgagctggt ccccttgcgg     1620

agagtgtagc agggccatca ccgagttcct gtccagatat ccacacgtga cactgtttat     1680

ctacatcgcc aggctgtatc accacgcaga cccaaggaat aggcagggcc tgcgcgatct     1740

gatcagctcc ggcgtgacca tccagatcat gacagagcag gagtccggct actgctggcg     1800

gaacttcgtg aattattctc ctagcaacga ggcccactgg cctaggtacc cacacctgtg     1860

ggtgcgcctg tacgtgctgg agctgtattg catcatcctg ggcctgcccc cttgtctgaa     1920

tatcctgcgg agaaagcagc cccagctgac cttctttaca atcgccctgc agtcttgtca     1980

ctatcagagg ctgccacccc acatcctgtg ggccacaggc ctgaagtctg gaggatctag     2040

cggaggatcc tctggcagcg agacaccagg aacaagcgag tcagcaacac cagagagcag     2100

tggcggcagc agcggcggca gcgacaagaa gtacagcatc ggcctggcca tcggcaccaa     2160

ctctgtgggc tgggccgtga tcaccgacga gtacaaggtg cccagcaaga aattcaaggt     2220

gctgggcaac accgaccggc acagcatcaa gaagaacctg atcggagccc tgctgttcga     2280

cagcggcgaa acagccgagg ccacccggct gaagagaacc gccagaagaa gatacaccag     2340

acggaagaac cggatctgct atctgcaaga gatcttcagc aacgagatgg ccaaggtgga     2400

cgacagcttc ttccacagac tggaagagtc cttcctggtg gaagaggata agaagcacga     2460

gcggcacccc atcttcggca acatcgtgga cgaggtggcc taccacgaga agtaccccac     2520

catctaccac ctgagaaaga aactggtgga cagcaccgac aaggccgacc tgcggctgat     2580

ctatctggcc ctggcccaca tgatcaagtt ccggggccac ttcctgatcg agggcgacct     2640

gaaccccgac aacagcgacg tggacaagct gttcatccag ctggtgcaga cctacaacca     2700

gctgttcgag gaaaacccca tcaacgccag cggcgtggac gccaaggcca tcctgtctgc     2760

cagactgagc aagagcagac ggctggaaaa tctgatcgcc cagctgcccg gcgagaagaa     2820

gaatggcctg ttcggaaacc tgattgccct gagcctgggc ctgaccccca acttcaagag     2880

caacttcgac ctggccgagg atgccaaact gcagctgagc aaggacacct acgacgacga     2940

cctggacaac ctgctggccc agatcggcga ccagtacgcc gacctgtttc tggccgccaa     3000

gaacctgtcc gacgccatcc tgctgagcga catcctgaga gtgaacaccg agatcaccaa     3060

ggcccccctg agcgcctcta tgatcaagag atacgacgag caccaccagg acctgaccct     3120

gctgaaagct ctcgtgcggc agcagctgcc tgagaagtac aaagagattt tcttcgacca     3180

gagcaagaac ggctacgccg gctacattga cggcggagcc agccaggaag agttctacaa     3240

gttcatcaag cccatcctgg aaaagatgga cggcaccgag gaactgctcg tgaagctgaa     3300

cagagaggac ctgctgcgga agcagcggac cttcgacaac ggcagcatcc cccaccagat     3360

ccacctggga gagctgcacg ccattctgcg gcggcaggaa gatttttacc cattcctgaa     3420

ggacaaccgg gaaaagatcg agaagatcct gaccttccgc atcccctact acgtgggccc     3480

tctggccagg ggaaacagca gattcgcctg gatgaccaga aagagcgagg aaaccatcac     3540

cccctggaac ttcgaggaag tggtggacaa gggcgcttcc gcccagagct tcatcgagcg     3600

gatgaccaac ttcgataaga acctgcccaa cgagaaggtg ctgcccaagc acagcctgct     3660

gtacgagtac ttcaccgtgt ataacgagct gaccaaagtg aaatacgtga ccgagggaat     3720

gagaaagccc gccttcctga gcggcgagca gaaaaaggcc atcgtggacc tgctgttcaa     3780

gaccaaccgg aaagtgaccg tgaagcagct gaaagaggac tacttcaaga aaatcgagtg     3840

cctgtcatac gaaaccgaga tactgacagt agaatatggc cttctgccaa tcgggaagat     3900

tgtggagaaa cggatagaat gcacagttta ctctgtcgat aacaatggta acatttatac     3960

tcagccagtt gcccagtggc acgaccgggg agagcaggaa gtattcgaat actgtctgga     4020

ggatggaagt ctcattaggg ccactaagga ccacaaattt atgacagtcg atggccagat     4080

gctgcctata gacgaaatct ttgagcgaga gttggacctc atgcgagttg acaaccttcc     4140

taattctggt ggttctaaaa gaaccgccga cggcagcgaa ttcgagccca agaagaagag     4200

gaaagtctaa gatctgataa tcaacctctg gattacaaaa tttgtgaaag attgactggt     4260

attcttaact atgttgctcc ttttacgcta tgtggatacg ctgctttaat gcctttgtat     4320

catgctattg cttcccgtat ggctttcatt ttctcctcct tgtataaatc ctggttagtt     4380

cttgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg     4440

ttgggcactg acaattccgt ggtgcgactg tgccttctag ttgccagcca tctgttgttt     4500

gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat     4560

aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg     4620

tggggcagga cagcaagggg gaggattggg aagacaatag caggcatgct ggggatgcgg     4680

tgggctctat gggcggccgc aggaacccct agtgatggag ttggccactc cctctctgcg     4740

cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg     4800

ggcggcctca gtgagcgagc gagcgcgcag                                      4830


<210>  645
<211>  4851
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  645
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggcctcta gactcgagaa ggtcgggcag gaagagggcc tatttcccat      180

gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta gaattaattt      240

gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat aatttcttgg      300

gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta ccgtaacttg      360

aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca cccgagacga      420

ttaatgcgtc tcggttttag agctagaaat agcaagttaa aataaggcta gtccgttatc      480

aacttgaaaa agtggcaccg agtcggtgct ttttttgcta gcggtacccg ttacataact      540

tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaatagt      600

aacgccaata gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca      660

cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg      720

taaatggccc gcctggcatt gtgcccagta catgacctta tgggactttc ctacttggca      780

gtacatctac gtattagtca tcgctattac catggtcgag gtgagcccca cgttctgctt      840

cactctcccc atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt      900

attttgtgca gcgatggggg cggggggggg gggggggcgc gcgccaggcg gggcggggcg      960

gggcgagggg cggggcgggg cgaggcggag aggtgcggcg gcagccaatc agagcggcgc     1020

gctccgaaag tttcctttta tggcgaggcg gcggcggcgg cggccctata aaaagcgaag     1080

cgcgcggcgg gcgggagtcg ctgcgacgct gccttcgccc cgtgccccgc tccgccgccg     1140

cctcgcgccg cccgccccgg ctctgactga ccgcgttact cccacaggtg agcgggcggg     1200

acggcccttc tcctccgggc tgtaattagc tgagcaagag gtaagggttt aagggatggt     1260

tggttggtgg ggtattaatg tttaattacc tggagcacct gcctgaaatc actttttttc     1320

aggttggacc ggtgccacca tgaagaggac tgccgatgga tcagagtttg aatctcccaa     1380

gaagaagagg aaagtaatca agatagctac aaggaagtat cttggcaaac aaaacgttta     1440

tgatattgga gtcgaaagag atcacaactt tgctctgaag aacggattca tagcttctaa     1500

ttgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     1560

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     1620

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     1680

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     1740

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     1800

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     1860

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     1920

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     1980

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     2040

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     2100

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     2160

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     2220

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     2280

gtccgactac gatgtggacc atatcgtgcc tcagagcttt ctgaaggacg actccatcga     2340

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     2400

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     2460

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     2520

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     2580

gatcctggac tcccggatga acactaagta cgacgagaat gacaagctga tccgggaagt     2640

gaaagtgatc accctgaagt ccaagctggt gtccgatttc cggaaggatt tccagtttta     2700

caaagtgcgc gagatcaaca actaccacca cgcccacgac gcctacctga acgccgtcgt     2760

gggaaccgcc ctgatcaaaa agtaccctaa gctggaaagc gagttcgtgt acggcgacta     2820

caaggtgtac gacgtgcgga agatgatcgc caagagcgag caggaaatcg gcaaggctac     2880

cgccaagtac ttcttctaca gcaacatcat gaactttttc aagaccgaga ttaccctggc     2940

caacggcgag atccggaagc ggcctctgat cgagacaaac ggcgaaaccg gggagatcgt     3000

gtgggataag ggccgggatt ttgccaccgt gcggaaagtg ctgagcatgc cccaagtgaa     3060

tatcgtgaaa aagaccgagg tgcagacagg cggcttcagc aaagagtcta tcctgcccaa     3120

gaggaacagc gataagctga tcgccagaaa gaaggactgg gaccctaaga agtacggcgg     3180

cttcgacagc cccaccgtgg cctattctgt gctggtggtg gccaaagtgg aaaagggcaa     3240

gtccaagaaa ctgaagagtg tgaaagagct gctggggatc accatcatgg aaagaagcag     3300

cttcgagaag aatcccatcg actttctgga agccaagggc tacaaagaag tgaaaaagga     3360

cctgatcatc aagctgccta agtactccct gttcgagctg gaaaacggcc ggaagagaat     3420

gctggcctct gccggcgaac tgcagaaggg aaacgaactg gccctgccct ccaaatatgt     3480

gaacttcctg tacctggcca gccactatga gaagctgaag ggctcccccg aggataatga     3540

gcagaaacag ctgtttgtgg aacagcacaa gcactacctg gacgagatca tcgagcagat     3600

cagcgagttc tccaagagag tgatcctggc cgacgctaat ctggacaaag tgctgtccgc     3660

ctacaacaag caccgggata agcccatcag agagcaggcc gagaatatca tccacctgtt     3720

taccctgacc aatctgggag cccctgccgc cttcaagtac tttgacacca ccatcgaccg     3780

gaagaggtac accagcacca aagaggtgct ggacgccacc ctgatccacc agagcatcac     3840

cggcctgtac gagacacgga tcgacctgtc tcagctggga ggtgacagcg gcgggagcgg     3900

cgggagcggg gggagcacta atctgagcga catcattgag aaggagactg ggaaacagct     3960

ggtcattcag gagtccatcc tgatgctgcc tgaggaggtg gaggaagtga tcggcaacaa     4020

gccagagtct gacatcctgg tgcacaccgc ctacgacgag tccacagatg agaatgtgat     4080

gctgctgacc tctgacgccc ccgagtataa gccttgggcc ctggtcatcc aggattctaa     4140

cggcgagaat aagatcaaga tgctgagcgg aggatccaaa agaaccgccg acggcagcga     4200

attcgagccc aagaagaaga ggaaagtcta agatctgata atcaacctct ggattacaaa     4260

atttgtgaaa gattgactgg tattcttaac tatgttgctc cttttacgct atgtggatac     4320

gctgctttaa tgcctttgta tcatgctatt gcttcccgta tggctttcat tttctcctcc     4380

ttgtataaat cctggttagt tcttgccacg gcggaactca tcgccgcctg ccttgcccgc     4440

tgctggacag gggctcggct gttgggcact gacaattccg tggtgcgact gtgccttcta     4500

gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca     4560

ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc     4620

attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata     4680

gcaggcatgc tggggatgcg gtgggctcta tgggcggccg caggaacccc tagtgatgga     4740

gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc     4800

ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca g              4851


<210>  646
<211>  4916
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  646
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggcctcta gatcagggta cccgttacat aacttacggt aaatggcccg      180

cctggctgac cgcccaacga cccccgccca ttgacgtcaa tagtaacgcc aatagggact      240

ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa      300

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg      360

cattgtgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta      420

gtcatcgcta ttaccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc      480

cccccctccc cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg      540

ggggcggggg gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc      600

ggggcgaggc ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct      660

tttatggcga ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga      720

gtcgctgcga cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc      780

ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc      840

gggctgtaat tagctgagca agaggtaagg gtttaaggga tggttggttg gtggggtatt      900

aatgtttaat tacctggagc acctgcctga aatcactttt tttcaggttg gaccggtgcc      960

accatgaaac ggacagccga cggaagcgag ttcgagtcac caaagaagaa gcggaaagtc     1020

tctgaagtcg agtttagcca cgagtattgg atgaggcacg cactgaccct ggcaaagcga     1080

gcatgggatg aaagagaagt ccccgtgggc gccgtgctgg tgcacaacaa tagagtgatc     1140

ggagagggat ggaacaggcc aatcggccgc cacgacccta ccgcacacgc agagatcatg     1200

gcactgaggc agggaggcct ggtcatgcag aattaccgcc tgatcgatgc caccctgtat     1260

gtgacactgg agccatgcgt gatgtgcgca ggagcaatga tccacagcag gatcggaaga     1320

gtggtgttcg gagcacggga cgccaagacc ggcgcagcag gctccctgat ggatgtgctg     1380

caccaccccg gcatgaacca ccgggtggag atcacagagg gaatcctggc agacgagtgc     1440

gccgccctgc tgagcgattt ctttagaatg cggagacagg agatcaaggc ccagaagaag     1500

gcacagagct ccaccgactc tggaggatct agcggaggat cctctggaag cgagacacca     1560

ggcacaagcg agtccgccac accagagagc tccggcggct cctccggagg atcctctgag     1620

gtggagtttt cccacgagta ctggatgaga catgccctga ccctggccaa gagggcacgc     1680

gatgagaggg aggtgcctgt gggagccgtg ctggtgctga acaatagagt gatcggcgag     1740

ggctggaaca gagccatcgg cctgcacgac ccaacagccc atgccgaaat tatggccctg     1800

agacagggcg gcctggtcat gcagaactac agactgattg acgccaccct gtacgtgaca     1860

ttcgagcctt gcgtgatgtg cgccggcgcc atgatccact ctaggatcgg ccgcgtggtg     1920

tttggcgtga ggaacgcaaa aaccggcgcc gcaggctccc tgatggacgt gctgcactac     1980

cccggcatga atcaccgcgt cgaaattacc gagggaatcc tggcagatga atgtgccgcc     2040

ctgctgtgct atttctttcg gatgcctaga caggtgttca atgctcagaa gaaggcccag     2100

agctccaccg actccggagg atctagcgga ggctcctctg gctctgagac acctggcaca     2160

agcgagagcg caacacctga aagcagcggg ggcagcagcg gggggtcaga caagaagtac     2220

agcatcggcc tggccatcgg caccaactct gtgggctggg ccgtgatcac cgacgagtac     2280

aaggtgccca gcaagaaatt caaggtgctg ggcaacaccg accggcacag catcaagaag     2340

aacctgatcg gagccctgct gttcgacagc ggcgaaacag ccgaggccac ccggctgaag     2400

agaaccgcca gaagaagata caccagacgg aagaaccgga tctgctatct gcaagagatc     2460

ttcagcaacg agatggccaa ggtggacgac agcttcttcc acagactgga agagtccttc     2520

ctggtggaag aggataagaa gcacgagcgg caccccatct tcggcaacat cgtggacgag     2580

gtggcctacc acgagaagta ccccaccatc taccacctga gaaagaaact ggtggacagc     2640

accgacaagg ccgacctgcg gctgatctat ctggccctgg cccacatgat caagttccgg     2700

ggccacttcc tgatcgaggg cgacctgaac cccgacaaca gcgacgtgga caagctgttc     2760

atccagctgg tgcagaccta caaccagctg ttcgaggaaa accccatcaa cgccagcggc     2820

gtggacgcca aggccatcct gtctgccaga ctgagcaaga gcagacggct ggaaaatctg     2880

atcgcccagc tgcccggcga gaagaagaat ggcctgttcg gaaacctgat tgccctgagc     2940

ctgggcctga cccccaactt caagagcaac ttcgacctgg ccgaggatgc caaactgcag     3000

ctgagcaagg acacctacga cgacgacctg gacaacctgc tggcccagat cggcgaccag     3060

tacgccgacc tgtttctggc cgccaagaac ctgtccgacg ccatcctgct gagcgacatc     3120

ctgagagtga acaccgagat caccaaggcc cccctgagcg cctctatgat caagagatac     3180

gacgagcacc accaggacct gaccctgctg aaagctctcg tgcggcagca gctgcctgag     3240

aagtacaaag agattttctt cgaccagagc aagaacggct acgccggcta cattgacggc     3300

ggagccagcc aggaagagtt ctacaagttc atcaagccca tcctggaaaa gatggacggc     3360

accgaggaac tgctcgtgaa gctgaacaga gaggacctgc tgcggaagca gcggaccttc     3420

gacaacggca gcatccccca ccagatccac ctgggagagc tgcacgccat tctgcggcgg     3480

caggaagatt tttacccatt cctgaaggac aaccgggaaa agatcgagaa gatcctgacc     3540

ttccgcatcc cctactacgt gggccctctg gccaggggaa acagcagatt cgcctggatg     3600

accagaaaga gcgaggaaac catcaccccc tggaacttcg aggaagtggt ggacaagggc     3660

gcttccgccc agagcttcat cgagcggatg accaacttcg ataagaacct gcccaacgag     3720

aaggtgctgc ccaagcacag cctgctgtac gagtacttca ccgtgtataa cgagctgacc     3780

aaagtgaaat acgtgaccga gggaatgaga aagcccgcct tcctgagcgg cgagcagaaa     3840

aaggccatcg tggacctgct gttcaagacc aaccggaaag tgaccgtgaa gcagctgaaa     3900

gaggactact tcaagaaaat cgagtgcctg tcctacgaga cagagatcct gacagtggag     3960

tatggcctgc tgccaatcgg caagatcgtg gagaagagga tcgagtgtac cgtgtactct     4020

gtggataaca atggcaacat ctatacacag cccgtggcac agtggcacga taggggagag     4080

caggaggtgt tcgagtattg cctggaggac ggcagcctga tcagggcaac caaggaccac     4140

aagttcatga cagtggatgg ccagatgctg cccatcgacg agattttcga gcgggagctg     4200

gacctgatga gagtggataa cctgcctaat agcggaggca gtaaaagaac agcagacggg     4260

agtgagtttg agcccaagaa aaagagaaag gtgtaagatc tgataatcaa cctctggatt     4320

acaaaatttg tgaaagattg actggtattc ttaactatgt tgctcctttt acgctatgtg     4380

gatacgctgc tttaatgcct ttgtatcatg ctattgcttc ccgtatggct ttcattttct     4440

cctccttgta taaatcctgg ttagttcttg ccacggcgga actcatcgcc gcctgccttg     4500

cccgctgctg gacaggggct cggctgttgg gcactgacaa ttccgtggtg cgactgtgcc     4560

ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg     4620

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag     4680

gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga     4740

caatagcagg catgctgggg atgcggtggg ctctatgggc ggccgcagga acccctagtg     4800

atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag     4860

gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcag         4916


<210>  647
<211>  5458
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  647
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggcctcta gatcagggta cccgttacat aacttacggt aaatggcccg      180

cctggctgac cgcccaacga cccccgccca ttgacgtcaa tagtaacgcc aatagggact      240

ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa      300

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg      360

cattgtgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta      420

gtcatcgcta ttaccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc      480

cccccctccc cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg      540

ggggcggggg gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc      600

ggggcgaggc ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct      660

tttatggcga ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga      720

gtcgctgcga cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc      780

ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc      840

gggctgtaat tagctgagca agaggtaagg gtttaaggga tggttggttg gtggggtatt      900

aatgtttaat tacctggagc acctgcctga aatcactttt tttcaggttg gaccggtgcc      960

accatgaaac ggacagccga cggaagcgag ttcgagtcac caaagaagaa gcggaaagtc     1020

atcaagattg ctacacggaa atacctggga aagcagaacg tgtacgacat cggcgtggag     1080

cgggatcaca acttcgccct gaagaatggc tttatcgcca gcaattgctt cgactccgtg     1140

gaaatctccg gcgtggaaga tcggttcaac gcctccctgg gcacatacca cgatctgctg     1200

aaaattatca aggacaagga cttcctggac aatgaggaaa acgaggacat tctggaagat     1260

atcgtgctga ccctgacact gtttgaggac agagagatga tcgaggaacg gctgaaaacc     1320

tatgcccacc tgttcgacga caaagtgatg aagcagctga agcggcggag atacaccggc     1380

tggggcaggc tgagccggaa gctgatcaac ggcatccggg acaagcagtc cggcaagaca     1440

atcctggatt tcctgaagtc cgacggcttc gccaacagaa acttcatgca gctgatccac     1500

gacgacagcc tgacctttaa agaggacatc cagaaagccc aggtgtccgg ccagggcgat     1560

agcctgcacg agcacattgc caatctggcc ggcagccccg ccattaagaa gggcatcctg     1620

cagacagtga aggtggtgga cgagctcgtg aaagtgatgg gccggcacaa gcccgagaac     1680

atcgtgatcg aaatggccag agagaaccag accacccaga agggacagaa gaacagccgc     1740

gagagaatga agcggatcga agagggcatc aaagagctgg gcagccagat cctgaaagaa     1800

caccccgtgg aaaacaccca gctgcagaac gagaagctgt acctgtacta cctgcagaat     1860

gggcgggata tgtacgtgga ccaggaactg gacatcaacc ggctgtccga ctacgatgtg     1920

gaccatatcg tgcctcagag ctttctgaag gacgactcca tcgacaacaa ggtgctgacc     1980

agaagcgaca agaaccgggg caagagcgac aacgtgccct ccgaagaggt cgtgaagaag     2040

atgaagaact actggcggca gctgctgaac gccaagctga ttacccagag aaagttcgac     2100

aatctgacca aggccgagag aggcggcctg agcgaactgg ataaggccgg cttcatcaag     2160

agacagctgg tggaaacccg gcagatcaca aagcacgtgg cacagatcct ggactcccgg     2220

atgaacacta agtacgacga gaatgacaag ctgatccggg aagtgaaagt gatcaccctg     2280

aagtccaagc tggtgtccga tttccggaag gatttccagt tttacaaagt gcgcgagatc     2340

aacaactacc accacgccca cgacgcctac ctgaacgccg tcgtgggaac cgccctgatc     2400

aaaaagtacc ctaagctgga aagcgagttc gtgtacggcg actacaaggt gtacgacgtg     2460

cggaagatga tcgccaagag cgagcaggaa atcggcaagg ctaccgccaa gtacttcttc     2520

tacagcaaca tcatgaactt tttcaagacc gagattaccc tggccaacgg cgagatccgg     2580

aagcggcctc tgatcgagac aaacggcgaa accggggaga tcgtgtggga taagggccgg     2640

gattttgcca ccgtgcggaa agtgctgagc atgccccaag tgaatatcgt gaaaaagacc     2700

gaggtgcaga caggcggctt cagcaaagag tctatcctgc ccaagaggaa cagcgataag     2760

ctgatcgcca gaaagaagga ctgggaccct aagaagtacg gcggcttcga cagccccacc     2820

gtggcctatt ctgtgctggt ggtggccaaa gtggaaaagg gcaagtccaa gaaactgaag     2880

agtgtgaaag agctgctggg gatcaccatc atggaaagaa gcagcttcga gaagaatccc     2940

atcgactttc tggaagccaa gggctacaaa gaagtgaaaa aggacctgat catcaagctg     3000

cctaagtact ccctgttcga gctggaaaac ggccggaaga gaatgctggc ctctgccggc     3060

gaactgcaga agggaaacga actggccctg ccctccaaat atgtgaactt cctgtacctg     3120

gccagccact atgagaagct gaagggctcc cccgaggata atgagcagaa acagctgttt     3180

gtggaacagc acaagcacta cctggacgag atcatcgagc agatcagcga gttctccaag     3240

agagtgatcc tggccgacgc taatctggac aaagtgctgt ccgcctacaa caagcaccgg     3300

gataagccca tcagagagca ggccgagaat atcatccacc tgtttaccct gaccaatctg     3360

ggagcccctg ccgccttcaa gtactttgac accaccatcg accggaagag gtacaccagc     3420

accaaagagg tgctggacgc caccctgatc caccagagca tcaccggcct gtacgagaca     3480

cggatcgacc tgtctcagct gggaggtgac tctggcggct caaaaagaac cgccgacggc     3540

agcgaattcg agcccaagaa gaagaggaaa gtctaagatc tgataatcaa cctctggatt     3600

acaaaatttg tgaaagattg actggtattc ttaactatgt tgctcctttt acgctatgtg     3660

gatacgctgc tttaatgcct ttgtatcatg ctattgcttc ccgtatggct ttcattttct     3720

cctccttgta taaatcctgg ttagttcttg ccacggcgga actcatcgcc gcctgccttg     3780

cccgctgctg gacaggggct cggctgttgg gcactgacaa ttccgtggtg cgactgtgcc     3840

ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg     3900

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag     3960

gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga     4020

caatagcagg catgctgggg atgcggtggg ctctatggct cgagaaaaaa agcaccgact     4080

cggtgccact ttttcaagtt gataacggac tagccttatt ttaacttgct atttctagct     4140

ctaaaaccga gacgtataaa cgcagaaagg cccacccgaa ggtgagccag tgtgactcta     4200

gtagagagcg ttcaccgaca aacaacagat aaaacgaaag gcccagtctt tcgactgagc     4260

ctttcgtttt atttgatgcc tggagatcct tattaagcac ccgtggagtg acgaccttca     4320

gcacgttcgt actgttcaac gatggtgtag tcttcgttgt gggaggtgat gtccagtttg     4380

atgtcggttt tgtaagcacc cggcagctga acgggttttt tagccatgta ggtggtttta     4440

acttcagcgt cgtagtgacc accgtctttc agtttcagac gcattttgat ttcacctttc     4500

agagcaccgt cttccgggta catacgttcg gtggaagctt cccaacccat ggtttttttc     4560

tgcataaccg gaccgtcgga cgggaagttg gtaccacgca gtttaacttt gtagatgaac     4620

tcaccgtctt gcagggagga gtcctgggta acggtaacaa caccaccgtc ttcgaagttc     4680

ataacacgtt cccatttgaa accttccggg aaggacagtt tcaggtagtc cgggatgtca     4740

gccgggtgtt taacgtaagc tttggaaccg tactggaact gcggggacag gatgtcccaa     4800

gcgaacggca gcggaccacc tttggtaact ttcagtttag cggtctgggt accttcgtac     4860

ggacgacctt caccttcacc ttcgatttcg aactcgtgac cgttaacgga accttccata     4920

cgaactttga aacgcatgaa ctctttgata acgtcttcgc tactcgccat agatcctttc     4980

tcctctttca gatccgtgct cagtatctct atcactgata gggatgtcaa tctctatcac     5040

tgatagggac gtctcgggtg tttcgtcctt tccacaagat atataaagcc aagaaatcga     5100

aatactttca agttacggta agcatatgat agtccatttt aaaacataat tttaaaactg     5160

caaactaccc aagaaattat tactttctac gtcacgtatt ttgtactaat atctttgtgt     5220

ttacagtcaa attaattcta attatctctc taacagcctt gtatcgtata tgcaaatatg     5280

aaggaatcat gggaaatagg ccctcttcct gcccgacctt gcggccgcag gaacccctag     5340

tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa     5400

aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcag       5458


<210>  648
<211>  4882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  648
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggcctcta gatcagggta cccgttacat aacttacggt aaatggcccg      180

cctggctgac cgcccaacga cccccgccca ttgacgtcaa tagtaacgcc aatagggact      240

ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa      300

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg      360

cattgtgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta      420

gtcatcgcta ttaccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc      480

cccccctccc cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg      540

ggggcggggg gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc      600

ggggcgaggc ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct      660

tttatggcga ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga      720

gtcgctgcga cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc      780

ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc      840

gggctgtaat tagctgagca agaggtaagg gtttaaggga tggttggttg gtggggtatt      900

aatgtttaat tacctggagc acctgcctga aatcactttt tttcaggttg gaccggtgcc      960

accatgaaac ggacagccga cggaagcgag ttcgagtcac caaagaagaa gcggaaagtc     1020

tcctcagaga ctgggcctgt cgccgtcgat ccaaccctgc gccgccggat tgaacctcac     1080

gagtttgaag tgttctttga cccccgggag ctgagaaagg agacatgcct gctgtacgag     1140

atcaactggg gaggcaggca ctccatctgg aggcacacct ctcagaacac aaataagcac     1200

gtggaggtga acttcatcga gaagtttacc acagagcggt acttctgccc caataccaga     1260

tgtagcatca catggtttct gagctggtcc ccttgcggag agtgtagcag ggccatcacc     1320

gagttcctgt ccagatatcc acacgtgaca ctgtttatct acatcgccag gctgtatcac     1380

cacgcagacc caaggaatag gcagggcctg cgcgatctga tcagctccgg cgtgaccatc     1440

cagatcatga cagagcagga gtccggctac tgctggcgga acttcgtgaa ttattctcct     1500

agcaacgagg cccactggcc taggtaccca cacctgtggg tgcgcctgta cgtgctggag     1560

ctgtattgca tcatcctggg cctgccccct tgtctgaata tcctgcggag aaagcagccc     1620

cagctgacct tctttacaat cgccctgcag tcttgtcact atcagaggct gccaccccac     1680

atcctgtggg ccacaggcct gaagtctgga ggatctagcg gaggatcctc tggcagcgag     1740

acaccaggaa caagcgagtc agcaacacca gagagcagtg gcggcagcag cggcggcagc     1800

gacaagaagt acagcatcgg cctggccatc ggcaccaact ctgtgggctg ggccgtgatc     1860

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac     1920

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc     1980

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat     2040

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg     2100

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac     2160

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa     2220

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg     2280

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg     2340

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc     2400

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg     2460

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg     2520

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat     2580

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag     2640

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg     2700

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg     2760

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     2820

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     2880

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     2940

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     3000

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     3060

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     3120

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     3180

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     3240

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     3300

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     3360

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     3420

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     3480

aagcagctga aagaggacta cttcaagaaa atcgagtgcc tgtcctacga gacagagatc     3540

ctgacagtgg agtatggcct gctgccaatc ggcaagatcg tggagaagag gatcgagtgt     3600

accgtgtact ctgtggataa caatggcaac atctatacac agcccgtggc acagtggcac     3660

gataggggag agcaggaggt gttcgagtat tgcctggagg acggcagcct gatcagggca     3720

accaaggacc acaagttcat gacagtggat ggccagatgc tgcccatcga cgagattttc     3780

gagcgggagc tggacctgat gagagtggat aacctgccta atagcggagg cagtaaaaga     3840

acagcagacg ggagtgagtt tgagcccaag aaaaagagaa aggtgtaaga tctgataatc     3900

aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat gttgctcctt     3960

ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct tcccgtatgg     4020

ctttcatttt ctcctccttg tataaatcct ggttagttct tgccacggcg gaactcatcg     4080

ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt gggcactgac aattccgtgg     4140

tgcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt     4200

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca     4260

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga     4320

ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg ctcgagaaaa     4380

aaagcaccga ctcggtgcca ctttttcaag ttgataacgg actagcctta ttttaacttg     4440

ctatttctag ctctaaaacc gagacgcatt aatcgtctcg ggtgtttcgt cctttccaca     4500

agatatataa agccaagaaa tcgaaatact ttcaagttac ggtaagcata tgatagtcca     4560

ttttaaaaca taattttaaa actgcaaact acccaagaaa ttattacttt ctacgtcacg     4620

tattttgtac taatatcttt gtgtttacag tcaaattaat tctaattatc tctctaacag     4680

ccttgtatcg tatatgcaaa tatgaaggaa tcatgggaaa taggccctct tcctgcccga     4740

ccttgcggcc gcaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     4800

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     4860

cagtgagcga gcgagcgcgc ag                                              4882


<210>  649
<211>  4849
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  649
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggcctcta gatcagggta cccgttacat aacttacggt aaatggcccg      180

cctggctgac cgcccaacga cccccgccca ttgacgtcaa tagtaacgcc aatagggact      240

ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa      300

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg      360

cattgtgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta      420

gtcatcgcta ttaccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc      480

cccccctccc cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg      540

ggggcggggg gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc      600

ggggcgaggc ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct      660

tttatggcga ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga      720

gtcgctgcga cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc      780

ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc      840

gggctgtaat tagctgagca agaggtaagg gtttaaggga tggttggttg gtggggtatt      900

aatgtttaat tacctggagc acctgcctga aatcactttt tttcaggttg gaccggtgcc      960

accatgaaac ggacagccga cggaagcgag ttcgagtcac caaagaagaa gcggaaagtc     1020

atcaagattg ctacacggaa atacctggga aagcagaacg tgtacgacat cggcgtggag     1080

cgggatcaca acttcgccct gaagaatggc tttatcgcca gcaattgctt cgactccgtg     1140

gaaatctccg gcgtggaaga tcggttcaac gcctccctgg gcacatacca cgatctgctg     1200

aaaattatca aggacaagga cttcctggac aatgaggaaa acgaggacat tctggaagat     1260

atcgtgctga ccctgacact gtttgaggac agagagatga tcgaggaacg gctgaaaacc     1320

tatgcccacc tgttcgacga caaagtgatg aagcagctga agcggcggag atacaccggc     1380

tggggcaggc tgagccggaa gctgatcaac ggcatccggg acaagcagtc cggcaagaca     1440

atcctggatt tcctgaagtc cgacggcttc gccaacagaa acttcatgca gctgatccac     1500

gacgacagcc tgacctttaa agaggacatc cagaaagccc aggtgtccgg ccagggcgat     1560

agcctgcacg agcacattgc caatctggcc ggcagccccg ccattaagaa gggcatcctg     1620

cagacagtga aggtggtgga cgagctcgtg aaagtgatgg gccggcacaa gcccgagaac     1680

atcgtgatcg aaatggccag agagaaccag accacccaga agggacagaa gaacagccgc     1740

gagagaatga agcggatcga agagggcatc aaagagctgg gcagccagat cctgaaagaa     1800

caccccgtgg aaaacaccca gctgcagaac gagaagctgt acctgtacta cctgcagaat     1860

gggcgggata tgtacgtgga ccaggaactg gacatcaacc ggctgtccga ctacgatgtg     1920

gaccatatcg tgcctcagag ctttctgaag gacgactcca tcgacaacaa ggtgctgacc     1980

agaagcgaca agaaccgggg caagagcgac aacgtgccct ccgaagaggt cgtgaagaag     2040

atgaagaact actggcggca gctgctgaac gccaagctga ttacccagag aaagttcgac     2100

aatctgacca aggccgagag aggcggcctg agcgaactgg ataaggccgg cttcatcaag     2160

agacagctgg tggaaacccg gcagatcaca aagcacgtgg cacagatcct ggactcccgg     2220

atgaacacta agtacgacga gaatgacaag ctgatccggg aagtgaaagt gatcaccctg     2280

aagtccaagc tggtgtccga tttccggaag gatttccagt tttacaaagt gcgcgagatc     2340

aacaactacc accacgccca cgacgcctac ctgaacgccg tcgtgggaac cgccctgatc     2400

aaaaagtacc ctaagctgga aagcgagttc gtgtacggcg actacaaggt gtacgacgtg     2460

cggaagatga tcgccaagag cgagcaggaa atcggcaagg ctaccgccaa gtacttcttc     2520

tacagcaaca tcatgaactt tttcaagacc gagattaccc tggccaacgg cgagatccgg     2580

aagcggcctc tgatcgagac aaacggcgaa accggggaga tcgtgtggga taagggccgg     2640

gattttgcca ccgtgcggaa agtgctgagc atgccccaag tgaatatcgt gaaaaagacc     2700

gaggtgcaga caggcggctt cagcaaagag tctatcctgc ccaagaggaa cagcgataag     2760

ctgatcgcca gaaagaagga ctgggaccct aagaagtacg gcggcttcga cagccccacc     2820

gtggcctatt ctgtgctggt ggtggccaaa gtggaaaagg gcaagtccaa gaaactgaag     2880

agtgtgaaag agctgctggg gatcaccatc atggaaagaa gcagcttcga gaagaatccc     2940

atcgactttc tggaagccaa gggctacaaa gaagtgaaaa aggacctgat catcaagctg     3000

cctaagtact ccctgttcga gctggaaaac ggccggaaga gaatgctggc ctctgccggc     3060

gaactgcaga agggaaacga actggccctg ccctccaaat atgtgaactt cctgtacctg     3120

gccagccact atgagaagct gaagggctcc cccgaggata atgagcagaa acagctgttt     3180

gtggaacagc acaagcacta cctggacgag atcatcgagc agatcagcga gttctccaag     3240

agagtgatcc tggccgacgc taatctggac aaagtgctgt ccgcctacaa caagcaccgg     3300

gataagccca tcagagagca ggccgagaat atcatccacc tgtttaccct gaccaatctg     3360

ggagcccctg ccgccttcaa gtactttgac accaccatcg accggaagag gtacaccagc     3420

accaaagagg tgctggacgc caccctgatc caccagagca tcaccggcct gtacgagaca     3480

cggatcgacc tgtctcagct gggaggtgac agcggcggga gcggcgggag cggggggagc     3540

actaatctga gcgacatcat tgagaaggag actgggaaac agctggtcat tcaggagtcc     3600

atcctgatgc tgcctgagga ggtggaggaa gtgatcggca acaagccaga gtctgacatc     3660

ctggtgcaca ccgcctacga cgagtccaca gatgagaatg tgatgctgct gacctctgac     3720

gcccccgagt ataagccttg ggccctggtc atccaggatt ctaacggcga gaataagatc     3780

aagatgctga gcggaggatc caaaagaacc gccgacggca gcgaattcga gcccaagaag     3840

aagaggaaag tctaagatct gataatcaac ctctggatta caaaatttgt gaaagattga     3900

ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt     3960

tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt     4020

tagttcttgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc     4080

ggctgttggg cactgacaat tccgtggtgc gactgtgcct tctagttgcc agccatctgt     4140

tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc     4200

ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg     4260

tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga     4320

tgcggtgggc tctatggctc gagaaaaaaa gcaccgactc ggtgccactt tttcaagttg     4380

ataacggact agccttattt taacttgcta tttctagctc taaaaccgag acgcattaat     4440

cgtctcgggt gtttcgtcct ttccacaaga tatataaagc caagaaatcg aaatactttc     4500

aagttacggt aagcatatga tagtccattt taaaacataa ttttaaaact gcaaactacc     4560

caagaaatta ttactttcta cgtcacgtat tttgtactaa tatctttgtg tttacagtca     4620

aattaattct aattatctct ctaacagcct tgtatcgtat atgcaaatat gaaggaatca     4680

tgggaaatag gccctcttcc tgcccgacct tgcggccgca ggaaccccta gtgatggagt     4740

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc     4800

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag                 4849


<210>  650
<211>  4773
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  650
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggcctcta gatcagggta cccgttacat aacttacggt aaatggcccg      180

cctggctgac cgcccaacga cccccgccca ttgacgtcaa tagtaacgcc aatagggact      240

ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa      300

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg      360

cattgtgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta      420

gtcatcgcta ttaccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc      480

cccccctccc cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg      540

ggggcggggg gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc      600

ggggcgaggc ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct      660

tttatggcga ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga      720

gtcgctgcga cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc      780

ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc      840

gggctgtaat tagctgagca agaggtaagg gtttaaggga tggttggttg gtggggtatt      900

aatgtttaat tacctggagc acctgcctga aatcactttt tttcaggttg gaccggtgcc      960

accatgaaac ggacagccga cggaagcgag ttcgagtcac caaagaagaa gcggaaagtc     1020

tcctcagaga ctgggcctgt cgccgtcgat ccaaccctgc gccgccggat tgaacctcac     1080

gagtttgaag tgttctttga cccccgggag ctgagaaagg agacatgcct gctgtacgag     1140

atcaactggg gaggcaggca ctccatctgg aggcacacct ctcagaacac aaataagcac     1200

gtggaggtga acttcatcga gaagtttacc acagagcggt acttctgccc caataccaga     1260

tgtagcatca catggtttct gagctggtcc ccttgcggag agtgtagcag ggccatcacc     1320

gagttcctgt ccagatatcc acacgtgaca ctgtttatct acatcgccag gctgtatcac     1380

cacgcagacc caaggaatag gcagggcctg cgcgatctga tcagctccgg cgtgaccatc     1440

cagatcatga cagagcagga gtccggctac tgctggcgga acttcgtgaa ttattctcct     1500

agcaacgagg cccactggcc taggtaccca cacctgtggg tgcgcctgta cgtgctggag     1560

ctgtattgca tcatcctggg cctgccccct tgtctgaata tcctgcggag aaagcagccc     1620

cagctgacct tctttacaat cgccctgcag tcttgtcact atcagaggct gccaccccac     1680

atcctgtggg ccacaggcct gaagtctgga ggatctagcg gaggatcctc tggcagcgag     1740

acaccaggaa caagcgagtc agcaacacca gagagcagtg gcggcagcag cggcggcagc     1800

gggaagcgaa attacattct ggggctggcc attggcatta catcagtggg ctatggcatc     1860

attgactacg agacaaggga cgtgatcgac gccggcgtga gactgttcaa ggaggccaac     1920

gtggagaaca atgagggccg gagatccaag aggggagcaa ggcgcctgaa gcggagaagg     1980

cgccacagaa tccagagagt gaagaagctg ctgttcgatt acaacctgct gaccgaccac     2040

tccgagctgt ctggcatcaa tccttatgag gccagagtga agggcctgtc ccagaagctg     2100

tctgaggagg agtttagcgc cgccctgctg cacctggcaa agaggagagg cgtgcacaac     2160

gtgaatgagg tggaggagga caccggcaac gagctgtcca caaaggagca gatcagccgc     2220

aattccaagg ccctggagga gaagtatgtg gccgagctgc agctggagcg gctgaagaag     2280

gatggcgagg tgaggggctc catcaatcgc ttcaagacct ctgactacgt gaaggaggcc     2340

aagcagctgc tgaaggtgca gaaggcctac caccagctgg atcagtcctt tatcgataca     2400

tatatcgacc tgctggagac aaggcgcaca tactatgagg gaccaggaga gggctctccc     2460

ttcggctgga aggacatcaa ggagtggtac gagatgctga tgggccactg cacctatttt     2520

ccagaggagc tgagaagcgt gaagtacgcc tataacgccg atctgtacaa cgccctgaat     2580

gacctgaaca acctggtcat caccagggat gagaacgaga agctggagta ctatgagaag     2640

ttccagatca tcgagaacgt gttcaagcag aagaagaagc ctacactgaa gcagatcgcc     2700

aaggagatcc tggtgaacga ggaggacatc aagggctacc gcgtgacctc cacaggcaag     2760

ccagagttca ccaatctgaa ggtgtatcac gatatcaagg acatcacagc ccggaaggag     2820

atcatcgaga acgccgagct gctggatcag atcgccaaga tcctgaccat ctatcagagc     2880

tccgaggaca tccaggagga gctgaccaac ctgaatagcg agctgacaca ggaggagatc     2940

gagcagatca gcaatctgaa gggctacacc ggcacacaca acctgagcct gaaggccatc     3000

aatctgatcc tggatgagct gtggcacaca aacgacaatc agatcgccat ctttaaccgg     3060

ctgaagctgg tgccaaagaa ggtggacctg tcccagcaga aggagatccc aaccacactg     3120

gtggacgatt tcatcctgtc tcccgtggtg aagcggagct tcatccagag catcaaagtg     3180

atcaacgcca tcatcaagaa gtacggcctg cccaatgata tcatcatcga gctggccagg     3240

gagaagaact ccaaggacgc ccagaagatg atcaatgaga tgcagaagag gaaccgccag     3300

accaatgagc ggatcgagga gatcatcaga accacaggca aggagaacgc caagtacctg     3360

atcgagaaga tcaagctgca cgatatgcag gagggcaagt gcctgtccta cgagacagag     3420

atcctgacag tggagtatgg cctgctgcca atcggcaaga tcgtggagaa gaggatcgag     3480

tgtaccgtgt actctgtgga taacaatggc aacatctata cacagcccgt ggcacagtgg     3540

cacgataggg gagagcagga ggtgttcgag tattgcctgg aggacggcag cctgatcagg     3600

gcaaccaagg accacaagtt catgacagtg gatggccaga tgctgcccat cgacgagatt     3660

ttcgagcggg agctggacct gatgagagtg gataacctgc ctaatagcgg aggcagtaaa     3720

agaacagcag acgggagtga gtttgagccc aagaaaaaga gaaaggtgta agatctgata     3780

atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc     3840

cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta     3900

tggctttcat tttctcctcc ttgtataaat cctggttagt tcttgccacg gcggaactca     3960

tcgccgcctg ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg     4020

tggtgcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc     4080

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     4140

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     4200

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggctcgaga     4260

aaaaaatctc gccaacaagt tgacgagata aacacggcat tttgccttgt tttagtagat     4320

tctgtaattt tcattacaga gtactaaaac cgagacgcat taatcgtctc gggtgtttcg     4380

tcctttccac aagatatata aagccaagaa atcgaaatac tttcaagtta cggtaagcat     4440

atgatagtcc attttaaaac ataattttaa aactgcaaac tacccaagaa attattactt     4500

tctacgtcac gtattttgta ctaatatctt tgtgtttaca gtcaaattaa ttctaattat     4560

ctctctaaca gccttgtatc gtatatgcaa atatgaagga atcatgggaa ataggccctc     4620

ttcctgcccg accttgcggc cgcaggaacc cctagtgatg gagttggcca ctccctctct     4680

gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc     4740

ccgggcggcc tcagtgagcg agcgagcgcg cag                                  4773


<210>  651
<211>  4032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  651
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggcctcta gatcagggta cccgttacat aacttacggt aaatggcccg      180

cctggctgac cgcccaacga cccccgccca ttgacgtcaa tagtaacgcc aatagggact      240

ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa      300

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg      360

cattgtgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta      420

gtcatcgcta ttaccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc      480

cccccctccc cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg      540

ggggcggggg gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc      600

ggggcgaggc ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct      660

tttatggcga ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga      720

gtcgctgcga cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc      780

ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc      840

gggctgtaat tagctgagca agaggtaagg gtttaaggga tggttggttg gtggggtatt      900

aatgtttaat tacctggagc acctgcctga aatcactttt tttcaggttg gaccggtgcc      960

accatgaaac ggacagccga cggaagcgag ttcgagtcac caaagaagaa gcggaaagtc     1020

atcaagattg ctacacggaa atacctggga aagcagaacg tgtacgacat cggcgtggag     1080

cgggatcaca acttcgccct gaagaatggc tttatcgcca gcaattgtct gtattctctg     1140

gaggccatcc ctctggagga cctgctgaac aatccattca actacgaggt ggatcacatc     1200

atcccccgga gcgtgagctt cgacaattct tttaacaata aggtgctggt gaagcaggag     1260

gagaacagca agaagggcaa taggacccct ttccagtacc tgtctagctc cgattctaag     1320

atcagctacg agacattcaa gaagcacatc ctgaatctgg ccaagggcaa gggccgcatc     1380

agcaagacca agaaggagta cctgctggag gagcgggaca tcaacagatt ctccgtgcag     1440

aaggacttca tcaaccggaa tctggtggac accagatacg ccacacgcgg cctgatgaat     1500

ctgctgcggt cttatttcag agtgaacaat ctggatgtga aggtgaagag catcaacggc     1560

ggcttcacct cctttctgcg gagaaagtgg aagtttaaga aggagcgcaa caagggctat     1620

aagcaccacg ccgaggatgc cctgatcatc gccaatgccg acttcatctt taaggagtgg     1680

aagaagctgg acaaggccaa gaaagtgatg gagaaccaga tgttcgagga gaagcaggcc     1740

gagagcatgc ccgagatcga gacagagcag gagtacaagg agattttcat cacacctcac     1800

cagatcaagc acatcaagga cttcaaggac tacaagtatt ctcacagggt ggataagaag     1860

cccaaccgcg agctgatcaa tgacaccctg tatagcacac ggaaggacga taagggcaat     1920

accctgatcg tgaacaatct gaacggcctg tacgacaagg ataatgacaa gctgaagaag     1980

ctgatcaaca agtctcccga gaagctgctg atgtaccacc acgatcctca gacatatcag     2040

aagctgaagc tgatcatgga gcagtacggc gacgagaaga acccactgta taagtactat     2100

gaggagacag gcaactacct gacaaagtat agcaagaagg ataatggccc cgtgatcaag     2160

aagatcaagt actatggcaa caagctgaat gcccacctgg acatcaccga cgattaccct     2220

aactctcgca ataaggtggt gaagctgagc ctgaagccat accggttcga cgtgtacctg     2280

gacaacggcg tgtataagtt tgtgacagtg aagaatctgg atgtgatcaa gaaggagaac     2340

tactatgagg tgaacagcaa gtgctacgag gaggccaaga agctgaagaa gatcagcaac     2400

caggccgagt tcatcgcctc tttttacaac aatgacctga tcaagatcaa tggcgagctg     2460

tatagagtga tcggcgtgaa caatgatctg ctgaacagaa tcgaagtgaa tatgatcgac     2520

atcacctaca gggagtatct ggagaacatg aatgataaga ggccccctcg catcatcaag     2580

accatcgcct ctaagacaca gagcatcaag aagtacagca cagacatcct ggggaacctg     2640

tatgaagtca agagcaagaa acatcctcag attatcaaga aaggcagcgg cgggagcggc     2700

gggagcgggg ggagcactaa tctgagcgac atcattgaga aggagactgg gaaacagctg     2760

gtcattcagg agtccatcct gatgctgcct gaggaggtgg aggaagtgat cggcaacaag     2820

ccagagtctg acatcctggt gcacaccgcc tacgacgagt ccacagatga gaatgtgatg     2880

ctgctgacct ctgacgcccc cgagtataag ccttgggccc tggtcatcca ggattctaac     2940

ggcgagaata agatcaagat gctgagcgga ggatccaaaa gaaccgccga cggcagcgaa     3000

ttcgagccca agaagaagag gaaagtctaa gatctgataa tcaacctctg gattacaaaa     3060

tttgtgaaag attgactggt attcttaact atgttgctcc ttttacgcta tgtggatacg     3120

ctgctttaat gcctttgtat catgctattg cttcccgtat ggctttcatt ttctcctcct     3180

tgtataaatc ctggttagtt cttgccacgg cggaactcat cgccgcctgc cttgcccgct     3240

gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgcgactg tgccttctag     3300

ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac     3360

tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca     3420

ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag     3480

caggcatgct ggggatgcgg tgggctctat ggctcgagaa aaaaatctcg ccaacaagtt     3540

gacgagataa acacggcatt ttgccttgtt ttagtagatt ctgtaatttt cattacagag     3600

tactaaaacc gagacgcatt aatcgtctcg ggtgtttcgt cctttccaca agatatataa     3660

agccaagaaa tcgaaatact ttcaagttac ggtaagcata tgatagtcca ttttaaaaca     3720

taattttaaa actgcaaact acccaagaaa ttattacttt ctacgtcacg tattttgtac     3780

taatatcttt gtgtttacag tcaaattaat tctaattatc tctctaacag ccttgtatcg     3840

tatatgcaaa tatgaaggaa tcatgggaaa taggccctct tcctgcccga ccttgcggcc     3900

gcaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga     3960

ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct cagtgagcga     4020

gcgagcgcgc ag                                                         4032


<210>  652
<211>  4789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  652
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggcctcta gatcagggta cccgttacat aacttacggt aaatggcccg      180

cctggctgac cgcccaacga cccccgccca ttgacgtcaa tagtaacgcc aatagggact      240

ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa      300

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg      360

cattgtgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta      420

gtcatcgcta ttaccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc      480

cccccctccc cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg      540

ggggcggggg gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc      600

ggggcgaggc ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct      660

tttatggcga ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga      720

gtcgctgcga cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc      780

ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc      840

gggctgtaat tagctgagca agaggtaagg gtttaaggga tggttggttg gtggggtatt      900

aatgtttaat tacctggagc acctgcctga aatcactttt tttcaggttg gaccggtgcc      960

accatgaaac ggacagccga cggaagcgag ttcgagtcac caaagaagaa gcggaaagtc     1020

gatagcctgc tgatgaatcg gaggaagttt ctgtaccagt tcaaaaatgt gcggtgggca     1080

aaagggcgaa gggagaccta cctgtgctat gtggtgaaga ggagagatag cgccaccagc     1140

ttctccctgg actttggcta cctgaggaac aagaatggct gccacgtgga gctgctgttc     1200

ctgcggtaca tctccgactg ggatctggac cccggccggt gttatcgcgt gacctggttc     1260

acatcttgga gcccttgcta cgattgtgcc aggcacgtgg ccgactttct gagaggcaac     1320

ccaaatctgt ctctgcggat cttcaccgcc cgcctgtatt tttgcgagga tcggaaggcc     1380

gagccagagg gcctgcggcg cctgcacagg gccggcgtgc agatcgccat catgacattc     1440

aaggactact tttattgttg gaacaccttc gtggagaatc acgagaggac cttcaaggcc     1500

tgggagggcc tgcacgagaa ctccgtgagg ctgagcaggc agctgaggag aatcctgctg     1560

cccctgtatg aagtggacga cctgcgggac gcctttagaa ctctgggact gtctggagga     1620

tctagcggag gatcctctgg cagcgagaca ccaggaacaa gcgagtcagc aacaccagag     1680

agcagtggcg gcagcagcgg cggcagcgac aagaagtaca gcatcggcct ggccatcggc     1740

accaactctg tgggctgggc cgtgatcacc gacgagtaca aggtgcccag caagaaattc     1800

aaggtgctgg gcaacaccga ccggcacagc atcaagaaga acctgatcgg agccctgctg     1860

ttcgacagcg gcgaaacagc cgaggccacc cggctgaaga gaaccgccag aagaagatac     1920

accagacgga agaaccggat ctgctatctg caagagatct tcagcaacga gatggccaag     1980

gtggacgaca gcttcttcca cagactggaa gagtccttcc tggtggaaga ggataagaag     2040

cacgagcggc accccatctt cggcaacatc gtggacgagg tggcctacca cgagaagtac     2100

cccaccatct accacctgag aaagaaactg gtggacagca ccgacaaggc cgacctgcgg     2160

ctgatctatc tggccctggc ccacatgatc aagttccggg gccacttcct gatcgagggc     2220

gacctgaacc ccgacaacag cgacgtggac aagctgttca tccagctggt gcagacctac     2280

aaccagctgt tcgaggaaaa ccccatcaac gccagcggcg tggacgccaa ggccatcctg     2340

tctgccagac tgagcaagag cagacggctg gaaaatctga tcgcccagct gcccggcgag     2400

aagaagaatg gcctgttcgg aaacctgatt gccctgagcc tgggcctgac ccccaacttc     2460

aagagcaact tcgacctggc cgaggatgcc aaactgcagc tgagcaagga cacctacgac     2520

gacgacctgg acaacctgct ggcccagatc ggcgaccagt acgccgacct gtttctggcc     2580

gccaagaacc tgtccgacgc catcctgctg agcgacatcc tgagagtgaa caccgagatc     2640

accaaggccc ccctgagcgc ctctatgatc aagagatacg acgagcacca ccaggacctg     2700

accctgctga aagctctcgt gcggcagcag ctgcctgaga agtacaaaga gattttcttc     2760

gaccagagca agaacggcta cgccggctac attgacggcg gagccagcca ggaagagttc     2820

tacaagttca tcaagcccat cctggaaaag atggacggca ccgaggaact gctcgtgaag     2880

ctgaacagag aggacctgct gcggaagcag cggaccttcg acaacggcag catcccccac     2940

cagatccacc tgggagagct gcacgccatt ctgcggcggc aggaagattt ttacccattc     3000

ctgaaggaca accgggaaaa gatcgagaag atcctgacct tccgcatccc ctactacgtg     3060

ggccctctgg ccaggggaaa cagcagattc gcctggatga ccagaaagag cgaggaaacc     3120

atcaccccct ggaacttcga ggaagtggtg gacaagggcg cttccgccca gagcttcatc     3180

gagcggatga ccaacttcga taagaacctg cccaacgaga aggtgctgcc caagcacagc     3240

ctgctgtacg agtacttcac cgtgtataac gagctgacca aagtgaaata cgtgaccgag     3300

ggaatgagaa agcccgcctt cctgagcggc gagcagaaaa aggccatcgt ggacctgctg     3360

ttcaagacca accggaaagt gaccgtgaag cagctgaaag aggactactt caagaaaatc     3420

gagtgcctgt cctacgagac agagatcctg acagtggagt atggcctgct gccaatcggc     3480

aagatcgtgg agaagaggat cgagtgtacc gtgtactctg tggataacaa tggcaacatc     3540

tatacacagc ccgtggcaca gtggcacgat aggggagagc aggaggtgtt cgagtattgc     3600

ctggaggacg gcagcctgat cagggcaacc aaggaccaca agttcatgac agtggatggc     3660

cagatgctgc ccatcgacga gattttcgag cgggagctgg acctgatgag agtggataac     3720

ctgcctaata gcggaggcag taaaagaaca gcagacggga gtgagtttga gcccaagaaa     3780

aagagaaagg tgtaagatct gataatcaac ctctggatta caaaatttgt gaaagattga     3840

ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt     3900

tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt     3960

tagttcttgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc     4020

ggctgttggg cactgacaat tccgtggtgc gactgtgcct tctagttgcc agccatctgt     4080

tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc     4140

ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg     4200

tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga     4260

tgcggtgggc tctatggctc gagaaaaaaa gcaccgactc ggtgccactt tttcaagttg     4320

ataacggact agccttattt taacttgcta tttctagctc taaaaccgag acgcattaat     4380

cgtctcgggt gtttcgtcct ttccacaaga tatataaagc caagaaatcg aaatactttc     4440

aagttacggt aagcatatga tagtccattt taaaacataa ttttaaaact gcaaactacc     4500

caagaaatta ttactttcta cgtcacgtat tttgtactaa tatctttgtg tttacagtca     4560

aattaattct aattatctct ctaacagcct tgtatcgtat atgcaaatat gaaggaatca     4620

tgggaaatag gccctcttcc tgcccgacct tgcggccgca ggaaccccta gtgatggagt     4680

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc     4740

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag                 4789


<210>  653
<211>  4849
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  653
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggcctcta gatcagggta cccgttacat aacttacggt aaatggcccg      180

cctggctgac cgcccaacga cccccgccca ttgacgtcaa tagtaacgcc aatagggact      240

ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa      300

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg      360

cattgtgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta      420

gtcatcgcta ttaccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc      480

cccccctccc cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg      540

ggggcggggg gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc      600

ggggcgaggc ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct      660

tttatggcga ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga      720

gtcgctgcga cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc      780

ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc      840

gggctgtaat tagctgagca agaggtaagg gtttaaggga tggttggttg gtggggtatt      900

aatgtttaat tacctggagc acctgcctga aatcactttt tttcaggttg gaccggtgcc      960

accatgaaac ggacagccga cggaagcgag ttcgagtcac caaagaagaa gcggaaagtc     1020

atcaagattg ctacacggaa atacctggga aagcagaacg tgtacgacat cggcgtggag     1080

cgggatcaca acttcgccct gaagaatggc tttatcgcca gcaattgctt cgactccgtg     1140

gaaatctccg gcgtggaaga tcggttcaac gcctccctgg gcacatacca cgatctgctg     1200

aaaattatca aggacaagga cttcctggac aatgaggaaa acgaggacat tctggaagat     1260

atcgtgctga ccctgacact gtttgaggac agagagatga tcgaggaacg gctgaaaacc     1320

tatgcccacc tgttcgacga caaagtgatg aagcagctga agcggcggag atacaccggc     1380

tggggcaggc tgagccggaa gctgatcaac ggcatccggg acaagcagtc cggcaagaca     1440

atcctggatt tcctgaagtc cgacggcttc gccaacagaa acttcatgca gctgatccac     1500

gacgacagcc tgacctttaa agaggacatc cagaaagccc aggtgtccgg ccagggcgat     1560

agcctgcacg agcacattgc caatctggcc ggcagccccg ccattaagaa gggcatcctg     1620

cagacagtga aggtggtgga cgagctcgtg aaagtgatgg gccggcacaa gcccgagaac     1680

atcgtgatcg aaatggccag agagaaccag accacccaga agggacagaa gaacagccgc     1740

gagagaatga agcggatcga agagggcatc aaagagctgg gcagccagat cctgaaagaa     1800

caccccgtgg aaaacaccca gctgcagaac gagaagctgt acctgtacta cctgcagaat     1860

gggcgggata tgtacgtgga ccaggaactg gacatcaacc ggctgtccga ctacgatgtg     1920

gaccatatcg tgcctcagag ctttctgaag gacgactcca tcgacaacaa ggtgctgacc     1980

agaagcgaca agaaccgggg caagagcgac aacgtgccct ccgaagaggt cgtgaagaag     2040

atgaagaact actggcggca gctgctgaac gccaagctga ttacccagag aaagttcgac     2100

aatctgacca aggccgagag aggcggcctg agcgaactgg ataaggccgg cttcatcaag     2160

agacagctgg tggaaacccg gcagatcaca aagcacgtgg cacagatcct ggactcccgg     2220

atgaacacta agtacgacga gaatgacaag ctgatccggg aagtgaaagt gatcaccctg     2280

aagtccaagc tggtgtccga tttccggaag gatttccagt tttacaaagt gcgcgagatc     2340

aacaactacc accacgccca cgacgcctac ctgaacgccg tcgtgggaac cgccctgatc     2400

aaaaagtacc ctaagctgga aagcgagttc gtgtacggcg actacaaggt gtacgacgtg     2460

cggaagatga tcgccaagag cgagcaggaa atcggcaagg ctaccgccaa gtacttcttc     2520

tacagcaaca tcatgaactt tttcaagacc gagattaccc tggccaacgg cgagatccgg     2580

aagcggcctc tgatcgagac aaacggcgaa accggggaga tcgtgtggga taagggccgg     2640

gattttgcca ccgtgcggaa agtgctgagc atgccccaag tgaatatcgt gaaaaagacc     2700

gaggtgcaga caggcggctt cagcaaagag tctatcctgc ccaagaggaa cagcgataag     2760

ctgatcgcca gaaagaagga ctgggaccct aagaagtacg gcggcttcga cagccccacc     2820

gtggcctatt ctgtgctggt ggtggccaaa gtggaaaagg gcaagtccaa gaaactgaag     2880

agtgtgaaag agctgctggg gatcaccatc atggaaagaa gcagcttcga gaagaatccc     2940

atcgactttc tggaagccaa gggctacaaa gaagtgaaaa aggacctgat catcaagctg     3000

cctaagtact ccctgttcga gctggaaaac ggccggaaga gaatgctggc ctctgccggc     3060

gaactgcaga agggaaacga actggccctg ccctccaaat atgtgaactt cctgtacctg     3120

gccagccact atgagaagct gaagggctcc cccgaggata atgagcagaa acagctgttt     3180

gtggaacagc acaagcacta cctggacgag atcatcgagc agatcagcga gttctccaag     3240

agagtgatcc tggccgacgc taatctggac aaagtgctgt ccgcctacaa caagcaccgg     3300

gataagccca tcagagagca ggccgagaat atcatccacc tgtttaccct gaccaatctg     3360

ggagcccctg ccgccttcaa gtactttgac accaccatcg accggaagag gtacaccagc     3420

accaaagagg tgctggacgc caccctgatc caccagagca tcaccggcct gtacgagaca     3480

cggatcgacc tgtctcagct gggaggtgac agcggcggga gcggcgggag cggggggagc     3540

actaatctga gcgacatcat tgagaaggag actgggaaac agctggtcat tcaggagtcc     3600

atcctgatgc tgcctgagga ggtggaggaa gtgatcggca acaagccaga gtctgacatc     3660

ctggtgcaca ccgcctacga cgagtccaca gatgagaatg tgatgctgct gacctctgac     3720

gcccccgagt ataagccttg ggccctggtc atccaggatt ctaacggcga gaataagatc     3780

aagatgctga gcggaggatc caaaagaacc gccgacggca gcgaattcga gcccaagaag     3840

aagaggaaag tctaagatct gataatcaac ctctggatta caaaatttgt gaaagattga     3900

ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt     3960

tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt     4020

tagttcttgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc     4080

ggctgttggg cactgacaat tccgtggtgc gactgtgcct tctagttgcc agccatctgt     4140

tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc     4200

ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg     4260

tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga     4320

tgcggtgggc tctatggctc gagaaaaaaa gcaccgactc ggtgccactt tttcaagttg     4380

ataacggact agccttattt taacttgcta tttctagctc taaaaccgag acgcattaat     4440

cgtctcgggt gtttcgtcct ttccacaaga tatataaagc caagaaatcg aaatactttc     4500

aagttacggt aagcatatga tagtccattt taaaacataa ttttaaaact gcaaactacc     4560

caagaaatta ttactttcta cgtcacgtat tttgtactaa tatctttgtg tttacagtca     4620

aattaattct aattatctct ctaacagcct tgtatcgtat atgcaaatat gaaggaatca     4680

tgggaaatag gccctcttcc tgcccgacct tgcggccgca ggaaccccta gtgatggagt     4740

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc     4800

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag                 4849


<210>  654
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is a, c, g, or t

<400>  654
gctaacagcc agtaacatca ngg                                               23


<210>  655
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  655
gctaacagcc agtaacatca cgg                                               23


<210>  656
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  656
gctaatagcc agtaacatca cgg                                               23


<210>  657
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  657
gctaaaaaac aataacatca tgg                                               23


<210>  658
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  658
tcaaatagcc agtaaaatca ggg                                               23


<210>  659
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  659
tctagcagac aataacatca ggg                                               23


<210>  660
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  660
gctaaaagaa agaaacatca agg                                               23


<210>  661
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  661
gataaaagcc aaaaacatca tgg                                               23


<210>  662
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  662
cagtttggtt cctcagtggc ctcgtgcttc ctgttcctca ggtggatg                    48


<210>  663
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  X may be Y or C

<400>  663

Gln Phe Gly Ser Ser Val Ala Ser Xaa Phe Leu Phe Leu Arg 
1               5                   10                  


<210>  664
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  664
catccacctg aggaacagga agcacgaggc cactgaggaa ccaaactg                    48


<210>  665
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  665
caggaagcac gaggccactg agg                                               23


<210>  666
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  666
aggaagcacg aggccactga gga                                               23


<210>  667
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  667
aacaggaagc acgaggccac tga                                               23


<210>  668
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is a, c, g, or t

<400>  668
caggaagcac gaggccactg ngg                                               23


<210>  669
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  669
ctccgcgagt accctgagca                                                   20


<210>  670
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  670
ctccatgagt accctgagca                                                   20


<210>  671
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  671
gccccttccg cgcgctccac g                                                 21


<210>  672
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  672
ttctacagcc acataaccag                                                   20


<210>  673
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  673
gtgatggaga gtcctcatac                                                   20


<210>  674
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  674
caggtcgacc aaggatacag                                                   20


<210>  675
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  675
cactgtatcc ttggtcaacc                                                   20


<210>  676
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  676
ttacgtggct ctggggcatc                                                   20


<210>  677
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  677
gacaacacta tcttcaacct                                                   20


<210>  678
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  678
tgtcctctac gaacagtacc                                                   20


<210>  679
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  679
cacaccggag gggagagggg                                                   20


<210>  680
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  680
tcgataggca ctgccgttaa                                                   20


<210>  681
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  681
cttacagcca gtaatgtcac                                                   20


<210>  682
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  682
aagtcaggct ttcttcagag                                                   20


<210>  683
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  683
ttgacactct gaagaaagcc                                                   20


<210>  684
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  684
gcgtggtagg tcatgaagta                                                   20


<210>  685
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  685
gtacgtgact ccgaccctgg                                                   20


<210>  686
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  686
actacaggca gcatgtcccc                                                   20


<210>  687
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  687
tcaagggaca tgctgcctat                                                   20


<210>  688
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  688
ctcagagggg agacttcatg                                                   20


<210>  689
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  689
cagcaaacgc aggcagggtc                                                   20


<210>  690
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  690
aactagtcag tgatattgtc                                                   20


<210>  691
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  691
tgtcaagtgg acaatatcac                                                   20


<210>  692
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  692
actcaacagc aagacgactg                                                   20


<210>  693
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  693
gcaagacaac tgtggcttca                                                   20


<210>  694
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  694
ggatgaagcc acagtcgtct                                                   20


<210>  695
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  695
tttcaactgg gtgaagccac                                                   20


<210>  696
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  696
gatcaacgat tatttcgact                                                   20


<210>  697
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  697
acaagggggc gaagcctatt                                                   20


<210>  698
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  698
ccaaataggc ttcgccccct                                                   20


<210>  699
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  699
gcaccgcgtt aaatatctgc                                                   20


<210>  700
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  700
ctactgcacc agggaatcat                                                   20


<210>  701
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  701
ctacaccagg gaatcattgt                                                   20


<210>  702
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  702
tgtgcagcgg catgggctgc                                                   20


<210>  703
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  703
gttctacccc ttggaagaag                                                   20


<210>  704
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  704
gcctatgtac tttgtcctgg                                                   20


<210>  705
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  705
gcagacccgc atgcaggtac                                                   20


<210>  706
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  706
gcatcaaaag agactgatcc                                                   20


<210>  707
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  707
agaacaggag tttttgaaga                                                   20


<210>  708
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  708
ttaaacatca agaggtaagt                                                   20


<210>  709
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  709
atacctagta ggcctgcacc                                                   20


<210>  710
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  710
caggatgact tcaatcacaa                                                   20


<210>  711
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  711
cactgtgatt gaagtcatcc                                                   20


<210>  712
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  712
gaaggtcaag ggcaacccaa                                                   20


<210>  713
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  713
tcatgctgag ctcggtggct                                                   20


<210>  714
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  714
tcaagtggat tcgaaggtct                                                   20


<210>  715
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  715
tctgataagc cggggggggg                                                   20


<210>  716
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  716
ccttgaggca catgaaaagc                                                   20


<210>  717
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  717
tcaccttcaa tacttcgttc                                                   20


<210>  718
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  718
tcattcagca gtgaaggaaa                                                   20


<210>  719
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  719
cacaggaaca ctggtccacc                                                   20


<210>  720
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  720
acaggtgggt catatgcaga                                                   20


<210>  721
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  721
tacagtaagt ggcaagagac                                                   20


<210>  722
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  722
accatacgca gtacagaaag                                                   20


<210>  723
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  723
actacgtacg gtaagtggca                                                   20


<210>  724
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  724
atacagtgaa agaggggcca                                                   20


<210>  725
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  725
ttataagtca agaacctgaa                                                   20


<210>  726
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  726
caagttcttg acttacaaat                                                   20


<210>  727
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  727
tgatatggag agtgtggaat                                                   20


<210>  728
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  728
ctatatgtca agcggaggtc                                                   20


<210>  729
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  729
ggaagtccaa agggtacatc                                                   20


<210>  730
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  730
agctactccg tccggaagaa                                                   20


<210>  731
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  731
ttccagacgg agcagctcat                                                   20


<210>  732
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  732
cagcataacc gctcgcggcc                                                   20


<210>  733
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  733
caggcaagcc tggctgctgg                                                   20


<210>  734
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  734
ctagtcagcc cccagcagcc                                                   20


<210>  735
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  735
aatccagctg acctctggtc                                                   20


<210>  736
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  736
ccaagagagg cgtcctgctg                                                   20


<210>  737
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  737
ggtcacgctg tggccgcgca                                                   20


<210>  738
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  738
tcttagcagc tacatggtgc                                                   20


<210>  739
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  739
aggcaggtat aaagattcca                                                   20


<210>  740
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  740
ctgtatggga aggacgctga                                                   20


<210>  741
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  741
tattataact ctttcacatt                                                   20


<210>  742
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  742
tctgtcaagg gctacatgtc                                                   20


<210>  743
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  743
tgacacgtag ccctcgacag                                                   20


