                         SEQUENCE LISTING

<110>  University of Georgia Research Foundation, Inc.
 
<120>  ANTIBODIES THAT BIND HUMAN METAPNEUMOVIRUS FUSION PROTEIN AND 
       THEIR USE

<130>  8618-102433-02

<150>  62/851,020
<151>  2019-05-21

<160>  72    

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Ser Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Arg Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ile Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Val Arg Gly Gly Tyr Asn Leu Trp His Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  2
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Tyr Glu Leu Ser Gln Ser Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Lys Leu Gly Asn Lys Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asp Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Gly Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Ser Cys Gln Ala Trp Asp Gly Arg Thr Ala Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  3
<211>  364
<212>  DNA
<213>  Homo sapiens

<400>  3
caggtgcagc tacagcagtg gggcgcagga ctcttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcagt ggttactctt ggacctggat tcgccagccc      120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac      180

ccgtccctca agagtcgagt caccatatca atagacacgt ccaggaacca gttctccctg      240

aagctgatct ctgtgaccgc cgcggacacg gctgtatatt attgtgcgag aggcgtgcgt      300

ggtggctaca atttgtggca ctttgacgtc tggggccagg gaaccctggt caccgtctcc      360

tcag                                                                   364


<210>  4
<211>  322
<212>  DNA
<213>  Homo sapiens

<400>  4
tcctatgagc tgagtcagtc accctcagtg tccgtgtctc caggacagac agccagaatc       60

acctgctctg gagataaatt ggggaataaa tatgcttcct ggtatcagca gaaaccaggc      120

cagtcccctg tgctggtcat ctatcaggat gacaagcggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacagcc actctgacca tcggcgggac ccaggctatg      240

gatgaggctg actattcctg tcaggcgtgg gacggcagaa ctgctgtggt tttcggcgga      300

gggaccaagc tgaccgtcct ag                                               322


<210>  5
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Gly Ser Phe Ser Gly Tyr Ser 
1               5               


<210>  6
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  6

Ile Asn His Ser Gly Ser Thr 
1               5           


<210>  7
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala Arg Gly Val Arg Gly Gly Tyr Asn Leu Trp His Phe Asp Val 
1               5                   10                  15  


<210>  8
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  8

Lys Leu Gly Asn Lys Tyr 
1               5       


<210>  9
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Asp Asp 
1           


<210>  10
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Ala Trp Asp Gly Arg Thr Ala Val Val 
1               5                   10  


<210>  11
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  11

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Gly Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gln Gly Arg Arg Tyr Tyr Tyr Ser Ser Gly Tyr Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  12
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Ile Val Met Thr Gln Ser Pro Ala Ala Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser His Ser Val Ala Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Arg Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  13
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  13
caggtgcagc tggtgcagtc tgggggaggc ggggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt catcttcagt gactatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa tcaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaggaa cacgctgtat      240

ctgcaaatga acagtctgag agttgaggac acggctgtat attactgtgc gaaagatcaa      300

gggaggaggt actattatag tagtggttat ctagactact ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210>  14
<211>  325
<212>  DNA
<213>  Homo sapiens

<400>  14
gacattgtga tgacccagtc tccagccgcc ctgtctgtgt ctccagggga acgagccacc       60

ctctcctgca gggccagtca cagtgttgcc agcaacctgg cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctctggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataggt ggcctccgtg gacgttcggc      300

caagggacca aggtggaaat caaac                                            325


<210>  15
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  15

Gly Phe Ile Phe Ser Asp Tyr Gly 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  16

Ile Ser Tyr Asp Gly Ser Asn Gln 
1               5               


<210>  17
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Lys Asp Gln Gly Arg Arg Tyr Tyr Tyr Ser Ser Gly Tyr Leu Asp 
1               5                   10                  15      


Tyr 
    


<210>  18
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  18

His Ser Val Ala Ser Asn 
1               5       


<210>  19
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  19

Gly Ala Ser 
1           


<210>  20
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Gln Tyr Asn Arg Trp Pro Pro Trp Thr 
1               5                   10  


<210>  21
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Asp Glu Ser Arg Arg Tyr Tyr Tyr Ser Ser Gly Ile His Ser 
            100                 105                 110         


His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  22
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  22

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Phe Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ala Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Asn Tyr Trp Pro Pro 
                85                  90                  95      


Gly Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  23
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  23
caggtgcagc tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt cagcttcagt gactatggca tggactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtggcagtt atatcatatg atggaagtaa tcaatactat      180

gcagactccg tgaagggccg attcaccgtc tccagagaca attccaagaa cacggtatat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt atttctgtgc aaaagatgaa      300

agtcgtaggt attattatag ttcagggatc catagccact ggggccaggg caccctggtc      360

accgtctcct ca                                                          372


<210>  24
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  24
gacattgtga tgacccagtc tccagccacc ctctctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc cgcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctttggt gcgtccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgcgtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcaccag tataattact ggcctccggg gacttttggc      300

caggggacca ggctggagat caaa                                             324


<210>  25
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Phe Ser Phe Ser Asp Tyr Gly 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  26

Ile Ser Tyr Asp Gly Ser Asn Gln 
1               5               


<210>  27
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Lys Asp Glu Ser Arg Arg Tyr Tyr Tyr Ser Ser Gly Ile His Ser 
1               5                   10                  15      


His 
    


<210>  28
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Ser Val Ser Arg Asn 
1               5       


<210>  29
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  29

Gly Ala Ser 
1           


<210>  30
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  30

His Gln Tyr Asn Tyr Trp Pro Pro Gly Thr 
1               5                   10  


<210>  31
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr His Asp 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Val Gly Asn Gly Asp Thr Lys Ser Ser Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Leu Thr Ile Thr Arg Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Arg Ser Leu Lys Tyr Glu Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Asp Gln Tyr Cys Ile Gly Gly Val Cys Tyr Gly Gly Lys 
            100                 105                 110         


Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  32
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  32

Ser Tyr Glu Leu Asn Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Met Ile Thr Cys Gly Gly Tyr Tyr Val Gly Val Lys Ser Leu 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ala Gly Gln Ala Pro Val Leu Val Val His 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Lys Ser Gly Asp Thr Ala Thr Leu Ile Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Arg Asp Ser Asp His 
                85                  90                  95      


Pro Tyr Val Phe Gly Thr Gly Thr Thr Val Thr Val Leu 
            100                 105                 


<210>  33
<211>  384
<212>  DNA
<213>  Homo sapiens

<400>  33
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact catgattcta tccattgggt gcgccaggcc      120

cccggacaaa ggcttgagtg gatgggatgg atcaacgttg gcaatggtga cacaaaatct      180

tcacagaagt ttcaggacag actcaccatt accagggaca catctgcgaa cacagcctac      240

atggaggtca gaagcctgaa atatgaagat acggctatgt atttctgtgc gagagtggac      300

caatattgta ttggtggtgt ctgctatggg ggaaagaatt ggttcgaccc ctggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210>  34
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  34
tcctatgagc tgaatcagcc accctcggtg tcggtggccc cagggcagac ggccatgatt       60

acctgtgggg gatattatgt cggagttaaa agtttgcact ggtaccaaca gaaggcaggc      120

caggcccctg tgctggtcgt ccatgatgat agcgaccggc cctctgggat ccctgagcga      180

ttctctggct ccaaatctgg cgacacggcc acactgatca tcagtagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagggata gtgatcatcc ttatgtcttc      300

ggaactggga ccacggtcac cgtcctg                                          327


<210>  35
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  35

Gly Tyr Thr Phe Thr His Asp Ser 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  36

Ile Asn Val Gly Asn Gly Asp Thr 
1               5               


<210>  37
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  37

Ala Arg Val Asp Gln Tyr Cys Ile Gly Gly Val Cys Tyr Gly Gly Lys 
1               5                   10                  15      


Asn Trp Phe Asp Pro 
            20      


<210>  38
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  38

Tyr Val Gly Val Lys Ser 
1               5       


<210>  39
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  39

Asp Asp Ser 
1           


<210>  40
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  40

Gln Val Trp Asp Arg Asp Ser Asp His Pro Tyr Val 
1               5                   10          


<210>  41
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  41

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Ser 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Val Phe Tyr Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ala Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Met Asp Thr Ser Lys Asn Thr Leu His Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Leu Ser Arg Ala Ser Gly Met Pro Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Pro Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  42
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  42

Glu Leu Ala Leu Ile Gln Pro Ala Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Thr Leu Thr Val Leu Gly Gln 
            100                 105             


<210>  43
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ala Ser Ser Ser Tyr Ser Asp Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Arg Ala Thr Gly Tyr Ser Ser Ile Thr Pro Tyr Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  44
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Arg Ser 
                85                  90                  95      


Leu Ser Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  45
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  45

Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu Asn Lys Gly 
1               5                   10                  15      


Cys Ser Tyr 
            


<210>  46
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  46

Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly 
1               5                   10                  15      


Cys Asp Tyr 
            


<210>  47
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  47

Ala Arg Val Asp Gln Tyr Cys Ile Gly Gly Val Cys Tyr Gly Gly Lys 
1               5                   10                  15      


Asn Trp Phe Asp Pro 
            20      


<210>  48
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Val Trp Asp Arg Asp Ser Asp His Pro Tyr Val 
1               5                   10          


<210>  49
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  49

Gln Gly Lys Leu Val Glu Ser Gly Gly Gly Val Ile Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Gly Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Val Tyr Ala Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Met His 
65                  70                  75                  80  


Leu Gln Met Ser Asp Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Ala Phe Asp Leu Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  50
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  50

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Gly Ile Ser Arg Ser 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Asp Ala Ser His Leu Glu Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Arg Ile 
                85                  90                  95      


Ser Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  51
<211>  345
<212>  DNA
<213>  Homo sapiens

<400>  51
caggggaagt tggtggagtc tgggggaggc gtgatccaac ctgggaggtc cctaagactc       60

tcttgtgcag cctctggatt cgacttcagt cgttatggtc tccactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt attgtatacg ctggaagtaa taaatattat      180

gcagactccg tgaagggccg attcaccatc tccaaagata attctaagaa cacgatgcat      240

ctgcaaatga gcgacctgag aactgaggac acggctgttt attactgtgc gagagaccag      300

gcttttgatc tctggggcca agggacaatg gtcaccgtgt cctca                      345


<210>  52
<211>  322
<212>  DNA
<213>  Homo sapiens

<400>  52
gacatccaga tgacccagtc tcctgcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca gggcattagc aggtctgtaa attggtacca gcagaagcca      120

gggaaagccc ctaaactcct gatcttcgat gcatcccatt tggaaagagg ggtcccatca      180

aggttcagtg gcagtggata tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcaacaa tatgataatc tccggatcag cttcggccaa      300

gggacacgac tcgagatcaa aa                                               322


<210>  53
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  53

Gly Phe Asp Phe Ser Arg Tyr Gly 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  54

Ile Val Tyr Ala Gly Ser Asn Lys 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  55

Ala Arg Asp Gln Ala Phe Asp Leu 
1               5               


<210>  56
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  56

Gln Gly Ile Ser Arg Ser 
1               5       


<210>  57
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  57

Asp Ala Ser 
1           


<210>  58
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  58

Gln Gln Tyr Asp Asn Leu Arg Ile Ser 
1               5                   


<210>  59
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  59

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Val Ala Ser Gly Phe Thr Phe Gly Thr Tyr 
            20                  25                  30          


Gly Met Tyr Trp Leu Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Trp Leu Asp Gly Ser Lys Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Lys Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Ser Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Pro Gly Ser Val Trp Tyr Asp Thr Arg Gly His Met Lys 
            100                 105                 110         


Gly Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ala Ser 
        115                 120                 125             


<210>  60
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  60

Gln Ser Val Leu Thr Gln Thr Pro Ser Val Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Glu Asn Asn 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asp Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Asn Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  61
<211>  385
<212>  DNA
<213>  Homo sapiens

<400>  61
gaagtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggacgtc cctgagactc       60

acctgtgtag cgtctggatt cacattcggt acttatggca tgtactggct ccgccagtct      120

ccaggcaagg ggctggagtg ggtggccttt atatggcttg atggaagtaa gacttactat      180

gcagactccg tgaagggccg attcaccgtc tccagagaca attccaagaa taagttgtat      240

ctggaaatga acagcctgag cgccgaggac acggcgatgt actactgtgc gagagcccca      300

ggctcggttt ggtatgacac tcgtggccat atgaaagggt ggttcgaccc ctggggccag      360

ggaaccctgg tcaccgtcgc ctcag                                            385


<210>  62
<211>  331
<212>  DNA
<213>  Homo sapiens

<400>  62
cagtctgtgc tgactcagac accctcagtg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgaa aataattatt tatactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat ggtgataatc ggcggccctc aggggtccct      180

gaccgattct ccggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaagatg aggctgatta ttactgtgca acatgggatg acaacctgag tggtccggtg      300

ttcggcggag ggaccaaggt gaccgtccta g                                     331


<210>  63
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  63

Gly Phe Thr Phe Gly Thr Tyr Gly 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  64

Ile Trp Leu Asp Gly Ser Lys Thr 
1               5               


<210>  65
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  65

Ala Arg Ala Pro Gly Ser Val Trp Tyr Asp Thr Arg Gly His Met Lys 
1               5                   10                  15      


Gly Trp Phe Asp Pro 
            20      


<210>  66
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  66

Ser Ser Asn Ile Glu Asn Asn Tyr 
1               5               


<210>  67
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  67

Gly Asp Asn 
1           


<210>  68
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  68

Ala Thr Trp Asp Asp Asn Leu Ser Gly Pro Val 
1               5                   10      


<210>  69
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  69

Lys Lys Arg Lys Arg Arg 
1               5       


<210>  70
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  70

Arg Gln Ser Arg 
1               


<210>  71
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  71

Arg Arg Arg Arg Arg Arg 
1               5       


<210>  72
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  72

Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu 
1               5                   10                  15      


Lys Thr Val Ser Ala Asp 
            20          


