                         SEQUENCE LISTING

<110>  Demetrix, Inc.
 
<120>  OPTIMIZED CANNABINOID SYNTHASE POLYPEPTIDES

<130>  DEMT-004/03WO 326934-2035

<150>  US 62/906,551
<151>  2019-09-26

<150>  US 62/906,017
<151>  2019-09-25

<150>  US 62/851,560
<151>  2019-05-22

<160>  323   

<170>  PatentIn version 3.5

<210>  1
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Cannabidiolic Acid (CBDA) Synthase Codon opt 2 Codon optimized

<400>  1
atgaaatgct ctaccttttc tttctggttc gtttgtaaga ttatcttctt cttcttctcc       60

ttcaacatcc aaacctctat cgctaaccct cgtgaaaact ttttgaaatg tttttcccaa      120

tacatcccaa ataacgctac taatttgaag ttggtttaca cccaaaacaa cccattgtat      180

atgtccgttt taaactctac tattcacaat ttgcgtttta cctctgatac tacccctaaa      240

ccattggtca ttgttacccc atcccatgtt tctcatatcc aaggtactat cttgtgttct      300

aaaaaggttg gtttgcaaat tagaactcgt tccggtggtc acgattctga aggtatgtct      360

tacatttctc aagttccttt cgtcattgtc gacttgagaa acatgagatc catcaaaatt      420

gatgttcact ctcaaactgc ttgggtcgaa gccggtgcca ctttaggtga ggtctactat      480

tgggttaacg agaagaacga aaacttgtct ttggctgccg gttactgtcc aactgtctgt      540

gctggtggtc attttggtgg tggtggttac ggtccattga tgagaaacta cggtttggct      600

gctgataaca ttattgatgc tcacttagtt aacgtccacg gtaaagtctt ggatagaaag      660

tccatgggtg aagacttgtt ctgggcttta agaggtggtg gtgctgaatc cttcggtatt      720

attgttgctt ggaaaatcag attggtcgct gttccaaaat ccaccatgtt ttctgtcaag      780

aaaatcatgg aaattcatga attagttaag ttggtcaaca aatggcaaaa cattgcctat      840

aaatacgaca aggatttgtt gttgatgact catttcatca ctcgtaacat cactgataat      900

caaggtaaga acaagactgc tatccatact tacttctctt ccgtcttctt gggtggtgtt      960

gactctttgg tcgatttgat gaacaaatcc tttccagagt taggtattaa gaagactgac     1020

tgtagacaat tatcttggat tgacactatt atcttctact ctggtgttgt caattacgat     1080

actgataact ttaacaagga aattttgttg gaccgttctg ctggtcaaaa cggtgccttc     1140

aagattaagt tagattacgt taagaagcca atcccagaat ctgtcttcgt ccaaattttg     1200

gagaaattgt atgaagagga cattggtgct ggtatgtacg ccttgtatcc ttacggtggt     1260

atcatggacg agatctccga atctgccatc ccttttcctc atcgtgctgg tatcttgtac     1320

gagttgtggt acatctgttc ctgggagaag caagaagata atgaaaagca cttgaactgg     1380

attagaaata tttataattt catgactcca tacgtttcta agaacccacg tttggcttac     1440

ttaaattaca gagatttgga tattggtatc aacgacccta agaaccctaa caactacact     1500

caagctagaa tttggggtga gaaatatttc ggtaagaact tcgatagatt ggtcaaggtt     1560

aaaactttag ttgatccaaa taactttttt agaaacgaac aatctattcc accattgcca     1620

agacacagac actag                                                      1635


<210>  2
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Cannabidiolic Acid (CBDA) Synthase Codon opt 5 Codon optimized

<400>  2
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  3
<211>  544
<212>  PRT
<213>  Cannabis sativa

<400>  3

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  4
<211>  2049
<212>  DNA
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  4
atgtttttca acagactaag cgctggcaag ctgctggtac cactctccgt ggtcctgtac       60

gcccttttcg tggtaatatt acctttacag aattctttcc actcctccaa tgttttagtt      120

agaggtgccg atgatgtaga aaactacgga actgttatcg gtattgactt aggtactact      180

tattcctgtg ttgctgtgat gaaaaatggt aagactgaaa ttcttgctaa tgagcaaggt      240

aacagaatca ccccatctta cgtggcattc accgatgatg aaagattgat tggtgatgct      300

gcaaagaacc aagttgctgc caatcctcaa aacaccatct tcgacattaa gagattgatc      360

ggtttgaaat ataacgacag atctgttcag aaggatatca agcacttgcc atttaatgtg      420

gttaataaag atgggaagcc cgctgtagaa gtaagtgtca aaggagaaaa gaaggttttt      480

actccagaag aaatttctgg tatgatcttg ggtaagatga aacaaattgc cgaagattat      540

ttaggcacta aggttaccca tgctgtcgtt actgttcctg cttatttcaa tgacgcgcaa      600

agacaagcca ccaaggatgc tggtaccatc gctggtttga acgttttgag aattgttaat      660

gaaccaaccg cagccgccat tgcctacggt ttggataaat ctgataagga acatcaaatt      720

attgtttatg atttgggtgg tggtactttc gatgtctctc tattgtctat tgaaaacggt      780

gttttcgaag tccaagccac ttctggtgat actcatttag gtggtgaaga ttttgactat      840

aagatcgttc gtcaattgat aaaagctttc aagaagaagc atggtattga tgtgtctgac      900

aacaacaagg ccctagctaa attgaagaga gaagctgaaa aggctaaacg tgccttgtcc      960

agccaaatgt ccacccgtat tgaaattgac tccttcgttg atggtatcga cttaagtgaa     1020

accttgacca gagctaagtt tgaggaatta aacctagatc tattcaagaa gaccttgaag     1080

cctgtcgaga aggttttgca agattctggt ttggaaaaga aggatgttga tgatatcgtt     1140

ttggttggtg gttctactag aattccaaag gtccaacaat tgttagaatc atactttgat     1200

ggtaagaagg cctccaaggg tattaaccca gatgaagctg ttgcatacgg tgcagccgtt     1260

caagctggtg tcttatccgg tgaagaaggt gtcgaagata ttgttttatt ggatgtcaac     1320

gctttgactc ttggtattga aaccactggt ggtgtcatga ctccattaat taagagaaat     1380

actgctattc ctacaaagaa atcccaaatt ttctctactg ccgttgacaa ccaaccaacc     1440

gttatgatca aggtatacga gggtgaaaga gccatgtcta aggacaacaa tctattaggt     1500

aagtttgaat taaccggcat tccaccagca ccaagaggtg tacctcaaat tgaagtcaca     1560

tttgcacttg acgctaatgg tattctgaag gtgtctgcca cagataaggg aactggtaaa     1620

tccgaatcta tcaccatcac taacgataaa ggtagattaa cccaagaaga gattgataga     1680

atggttgaag aggctgaaaa attcgcttct gaagacgctt ctatcaaggc caaggttgaa     1740

tctagaaaca aattagaaaa ctacgctcac tctttgaaaa accaagttaa tggtgaccta     1800

ggtgaaaaat tggaagaaga agacaaggaa accttattag atgctgctaa cgatgtttta     1860

gaatggttag atgataactt tgaaaccgcc attgctgaag actttgatga aaagttcgaa     1920

tctttgtcca aggtcgctta tccaattact tctaagttgt acggaggtgc tgatggttct     1980

ggtgccgctg attatgacga cgaagatgaa gatgacgatg gtgattattt cgaacacgac     2040

gaattgtag                                                             2049


<210>  5
<211>  682
<212>  PRT
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  5

Met Phe Phe Asn Arg Leu Ser Ala Gly Lys Leu Leu Val Pro Leu Ser 
1               5                   10                  15      


Val Val Leu Tyr Ala Leu Phe Val Val Ile Leu Pro Leu Gln Asn Ser 
            20                  25                  30          


Phe His Ser Ser Asn Val Leu Val Arg Gly Ala Asp Asp Val Glu Asn 
        35                  40                  45              


Tyr Gly Thr Val Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser Cys Val 
    50                  55                  60                  


Ala Val Met Lys Asn Gly Lys Thr Glu Ile Leu Ala Asn Glu Gln Gly 
65                  70                  75                  80  


Asn Arg Ile Thr Pro Ser Tyr Val Ala Phe Thr Asp Asp Glu Arg Leu 
                85                  90                  95      


Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Ala Asn Pro Gln Asn Thr 
            100                 105                 110         


Ile Phe Asp Ile Lys Arg Leu Ile Gly Leu Lys Tyr Asn Asp Arg Ser 
        115                 120                 125             


Val Gln Lys Asp Ile Lys His Leu Pro Phe Asn Val Val Asn Lys Asp 
    130                 135                 140                 


Gly Lys Pro Ala Val Glu Val Ser Val Lys Gly Glu Lys Lys Val Phe 
145                 150                 155                 160 


Thr Pro Glu Glu Ile Ser Gly Met Ile Leu Gly Lys Met Lys Gln Ile 
                165                 170                 175     


Ala Glu Asp Tyr Leu Gly Thr Lys Val Thr His Ala Val Val Thr Val 
            180                 185                 190         


Pro Ala Tyr Phe Asn Asp Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly 
        195                 200                 205             


Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Val Asn Glu Pro Thr Ala 
    210                 215                 220                 


Ala Ala Ile Ala Tyr Gly Leu Asp Lys Ser Asp Lys Glu His Gln Ile 
225                 230                 235                 240 


Ile Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Val Ser Leu Leu Ser 
                245                 250                 255     


Ile Glu Asn Gly Val Phe Glu Val Gln Ala Thr Ser Gly Asp Thr His 
            260                 265                 270         


Leu Gly Gly Glu Asp Phe Asp Tyr Lys Ile Val Arg Gln Leu Ile Lys 
        275                 280                 285             


Ala Phe Lys Lys Lys His Gly Ile Asp Val Ser Asp Asn Asn Lys Ala 
    290                 295                 300                 


Leu Ala Lys Leu Lys Arg Glu Ala Glu Lys Ala Lys Arg Ala Leu Ser 
305                 310                 315                 320 


Ser Gln Met Ser Thr Arg Ile Glu Ile Asp Ser Phe Val Asp Gly Ile 
                325                 330                 335     


Asp Leu Ser Glu Thr Leu Thr Arg Ala Lys Phe Glu Glu Leu Asn Leu 
            340                 345                 350         


Asp Leu Phe Lys Lys Thr Leu Lys Pro Val Glu Lys Val Leu Gln Asp 
        355                 360                 365             


Ser Gly Leu Glu Lys Lys Asp Val Asp Asp Ile Val Leu Val Gly Gly 
    370                 375                 380                 


Ser Thr Arg Ile Pro Lys Val Gln Gln Leu Leu Glu Ser Tyr Phe Asp 
385                 390                 395                 400 


Gly Lys Lys Ala Ser Lys Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr 
                405                 410                 415     


Gly Ala Ala Val Gln Ala Gly Val Leu Ser Gly Glu Glu Gly Val Glu 
            420                 425                 430         


Asp Ile Val Leu Leu Asp Val Asn Ala Leu Thr Leu Gly Ile Glu Thr 
        435                 440                 445             


Thr Gly Gly Val Met Thr Pro Leu Ile Lys Arg Asn Thr Ala Ile Pro 
    450                 455                 460                 


Thr Lys Lys Ser Gln Ile Phe Ser Thr Ala Val Asp Asn Gln Pro Thr 
465                 470                 475                 480 


Val Met Ile Lys Val Tyr Glu Gly Glu Arg Ala Met Ser Lys Asp Asn 
                485                 490                 495     


Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile Pro Pro Ala Pro Arg 
            500                 505                 510         


Gly Val Pro Gln Ile Glu Val Thr Phe Ala Leu Asp Ala Asn Gly Ile 
        515                 520                 525             


Leu Lys Val Ser Ala Thr Asp Lys Gly Thr Gly Lys Ser Glu Ser Ile 
    530                 535                 540                 


Thr Ile Thr Asn Asp Lys Gly Arg Leu Thr Gln Glu Glu Ile Asp Arg 
545                 550                 555                 560 


Met Val Glu Glu Ala Glu Lys Phe Ala Ser Glu Asp Ala Ser Ile Lys 
                565                 570                 575     


Ala Lys Val Glu Ser Arg Asn Lys Leu Glu Asn Tyr Ala His Ser Leu 
            580                 585                 590         


Lys Asn Gln Val Asn Gly Asp Leu Gly Glu Lys Leu Glu Glu Glu Asp 
        595                 600                 605             


Lys Glu Thr Leu Leu Asp Ala Ala Asn Asp Val Leu Glu Trp Leu Asp 
    610                 615                 620                 


Asp Asn Phe Glu Thr Ala Ile Ala Glu Asp Phe Asp Glu Lys Phe Glu 
625                 630                 635                 640 


Ser Leu Ser Lys Val Ala Tyr Pro Ile Thr Ser Lys Leu Tyr Gly Gly 
                645                 650                 655     


Ala Asp Gly Ser Gly Ala Ala Asp Tyr Asp Asp Glu Asp Glu Asp Asp 
            660                 665                 670         


Asp Gly Asp Tyr Phe Glu His Asp Glu Leu 
        675                 680         


<210>  6
<211>  1692
<212>  DNA
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  6
atgagattaa gaaccgccat tgccacactg tgcctcacgg cttttacatc tgcaacttca       60

aacaatagct acatcgccac cgaccaaaca caaaatgcct ttaatgacac tcacttttgt      120

aaggtcgaca ggaatgatca cgttagtccc agttgtaacg taacattcaa tgaattaaat      180

gccataaatg aaaacattag agatgatctt tcggcgttat taaaatctga tttcttcaaa      240

tactttcggc tggatttata caagcaatgt tcattttggg acgccaacga tggtctgtgc      300

ttaaaccgcg cttgctctgt tgatgtcgta gaggactggg atacactgcc tgagtactgg      360

cagcctgaga tcttgggtag tttcaataat gatacaatga aggaagcgga tgatagcgat      420

gacgaatgta agttcttaga tcaactatgt caaaccagta aaaaacctgt agatatcgaa      480

gacaccatca actactgtga tgtaaatgac tttaacggta aaaacgccgt tctgattgat      540

ttaacagcaa atccggaacg atttacaggt tatggtggta agcaagctgg tcaaatttgg      600

tctactatct accaagacaa ctgttttaca attggcgaaa ctggtgaatc attggccaaa      660

gatgcatttt atagacttgt atccggtttc catgcctcta tcggtactca cttatcaaag      720

gaatatttga acacgaaaac tggtaaatgg gagcccaatc tggatttgtt tatggcaaga      780

atcgggaact ttcctgatag agtgacaaac atgtatttca attatgctgt tgtagctaag      840

gctctctgga aaattcaacc atatttacca gaattttcat tctgtgatct agtcaataaa      900

gaaatcaaaa acaaaatgga taacgttatt tcccagctgg acacaaaaat ttttaacgaa      960

gacttagttt ttgccaacga cctaagtttg actttgaagg acgaattcag atctcgcttc     1020

aagaatgtca cgaagattat ggattgtgtg caatgtgata gatgtagatt gtggggcaaa     1080

attcaaacta ccggttacgc aactgccttg aaaattttgt ttgaaatcaa cgacgctgat     1140

gaattcacca aacaacatat tgttggtaag ttaaccaaat atgagttgat tgcactatta     1200

caaactttcg gtagattatc tgaatctatt gaatctgtta acatgttcga aaaaatgtac     1260

gggaaaaggt taaacggttc tgaaaacagg ttaagctcat tcttccaaaa taacttcttc     1320

aacattttga aggaggcagg caagtcgatt cgttacacca tagagaacat caattccact     1380

aaagaaggaa agaaaaagac taacaattct caatcacatg tatttgatga tttaaaaatg     1440

cccaaagcag aaatagttcc aaggccctct aacggtacag taaataaatg gaagaaagct     1500

tggaatactg aagttaacaa cgttttagaa gcattcagat ttatttatag aagctatttg     1560

gatttaccca ggaacatctg ggaattatct ttgatgaagg tatacaaatt ttggaataaa     1620

ttcatcggtg ttgctgatta cgttagtgag gagacacgag agcctatttc ctataagcta     1680

gatatacaat aa                                                         1692


<210>  7
<211>  563
<212>  PRT
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  7

Met Arg Leu Arg Thr Ala Ile Ala Thr Leu Cys Leu Thr Ala Phe Thr 
1               5                   10                  15      


Ser Ala Thr Ser Asn Asn Ser Tyr Ile Ala Thr Asp Gln Thr Gln Asn 
            20                  25                  30          


Ala Phe Asn Asp Thr His Phe Cys Lys Val Asp Arg Asn Asp His Val 
        35                  40                  45              


Ser Pro Ser Cys Asn Val Thr Phe Asn Glu Leu Asn Ala Ile Asn Glu 
    50                  55                  60                  


Asn Ile Arg Asp Asp Leu Ser Ala Leu Leu Lys Ser Asp Phe Phe Lys 
65                  70                  75                  80  


Tyr Phe Arg Leu Asp Leu Tyr Lys Gln Cys Ser Phe Trp Asp Ala Asn 
                85                  90                  95      


Asp Gly Leu Cys Leu Asn Arg Ala Cys Ser Val Asp Val Val Glu Asp 
            100                 105                 110         


Trp Asp Thr Leu Pro Glu Tyr Trp Gln Pro Glu Ile Leu Gly Ser Phe 
        115                 120                 125             


Asn Asn Asp Thr Met Lys Glu Ala Asp Asp Ser Asp Asp Glu Cys Lys 
    130                 135                 140                 


Phe Leu Asp Gln Leu Cys Gln Thr Ser Lys Lys Pro Val Asp Ile Glu 
145                 150                 155                 160 


Asp Thr Ile Asn Tyr Cys Asp Val Asn Asp Phe Asn Gly Lys Asn Ala 
                165                 170                 175     


Val Leu Ile Asp Leu Thr Ala Asn Pro Glu Arg Phe Thr Gly Tyr Gly 
            180                 185                 190         


Gly Lys Gln Ala Gly Gln Ile Trp Ser Thr Ile Tyr Gln Asp Asn Cys 
        195                 200                 205             


Phe Thr Ile Gly Glu Thr Gly Glu Ser Leu Ala Lys Asp Ala Phe Tyr 
    210                 215                 220                 


Arg Leu Val Ser Gly Phe His Ala Ser Ile Gly Thr His Leu Ser Lys 
225                 230                 235                 240 


Glu Tyr Leu Asn Thr Lys Thr Gly Lys Trp Glu Pro Asn Leu Asp Leu 
                245                 250                 255     


Phe Met Ala Arg Ile Gly Asn Phe Pro Asp Arg Val Thr Asn Met Tyr 
            260                 265                 270         


Phe Asn Tyr Ala Val Val Ala Lys Ala Leu Trp Lys Ile Gln Pro Tyr 
        275                 280                 285             


Leu Pro Glu Phe Ser Phe Cys Asp Leu Val Asn Lys Glu Ile Lys Asn 
    290                 295                 300                 


Lys Met Asp Asn Val Ile Ser Gln Leu Asp Thr Lys Ile Phe Asn Glu 
305                 310                 315                 320 


Asp Leu Val Phe Ala Asn Asp Leu Ser Leu Thr Leu Lys Asp Glu Phe 
                325                 330                 335     


Arg Ser Arg Phe Lys Asn Val Thr Lys Ile Met Asp Cys Val Gln Cys 
            340                 345                 350         


Asp Arg Cys Arg Leu Trp Gly Lys Ile Gln Thr Thr Gly Tyr Ala Thr 
        355                 360                 365             


Ala Leu Lys Ile Leu Phe Glu Ile Asn Asp Ala Asp Glu Phe Thr Lys 
    370                 375                 380                 


Gln His Ile Val Gly Lys Leu Thr Lys Tyr Glu Leu Ile Ala Leu Leu 
385                 390                 395                 400 


Gln Thr Phe Gly Arg Leu Ser Glu Ser Ile Glu Ser Val Asn Met Phe 
                405                 410                 415     


Glu Lys Met Tyr Gly Lys Arg Leu Asn Gly Ser Glu Asn Arg Leu Ser 
            420                 425                 430         


Ser Phe Phe Gln Asn Asn Phe Phe Asn Ile Leu Lys Glu Ala Gly Lys 
        435                 440                 445             


Ser Ile Arg Tyr Thr Ile Glu Asn Ile Asn Ser Thr Lys Glu Gly Lys 
    450                 455                 460                 


Lys Lys Thr Asn Asn Ser Gln Ser His Val Phe Asp Asp Leu Lys Met 
465                 470                 475                 480 


Pro Lys Ala Glu Ile Val Pro Arg Pro Ser Asn Gly Thr Val Asn Lys 
                485                 490                 495     


Trp Lys Lys Ala Trp Asn Thr Glu Val Asn Asn Val Leu Glu Ala Phe 
            500                 505                 510         


Arg Phe Ile Tyr Arg Ser Tyr Leu Asp Leu Pro Arg Asn Ile Trp Glu 
        515                 520                 525             


Leu Ser Leu Met Lys Val Tyr Lys Phe Trp Asn Lys Phe Ile Gly Val 
    530                 535                 540                 


Ala Asp Tyr Val Ser Glu Glu Thr Arg Glu Pro Ile Ser Tyr Lys Leu 
545                 550                 555                 560 


Asp Ile Gln 
            


<210>  8
<211>  1569
<212>  DNA
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  8
atgaagtttt ctgctggtgc cgtcctgtca tggtcctccc tgctgctcgc ctcctctgtt       60

ttcgcccaac aagaggctgt ggcccctgaa gactccgctg tcgttaagtt ggccaccgac      120

tccttcaatg agtacattca gtcgcacgac ttggtgcttg cggagttttt tgctccatgg      180

tgtggccact gtaagaacat ggctcctgaa tacgttaaag ccgccgagac tttagttgag      240

aaaaacatta ccttggccca gatcgactgt actgaaaacc aggatctgtg tatggaacac      300

aacattccag ggttcccaag cttgaagatt ttcaaaaaca gcgatgttaa caactcgatc      360

gattacgagg gacctagaac tgccgaggcc attgtccaat tcatgatcaa gcaaagccaa      420

ccggctgtcg ccgttgttgc tgatctacca gcttaccttg ctaacgagac ttttgtcact      480

ccagttatcg tccaatccgg taagattgac gccgacttca acgccacctt ttactccatg      540

gccaacaaac acttcaacga ctacgacttt gtctccgctg aaaacgcaga cgatgatttc      600

aagctttcta tttacttgcc ctccgccatg gacgagcctg tagtatacaa cggtaagaaa      660

gccgatatcg ctgacgctga tgtttttgaa aaatggttgc aagtggaagc cttgccctac      720

tttggtgaaa tcgacggttc cgttttcgcc caatacgtcg aaagcggttt gcctttgggt      780

tacttattct acaatgacga ggaagaattg gaagaataca agcctctctt taccgagttg      840

gccaaaaaga acagaggtct aatgaacttt gttagcatcg atgccagaaa attcggcaga      900

cacgccggca acttgaacat gaaggaacaa ttccctctat ttgccatcca cgacatgact      960

gaagacttga agtacggttt gcctcaactc tctgaagagg cgtttgacga attgagcgac     1020

aagatcgtgt tggagtctaa ggctattgaa tctttggtta aggacttctt gaaaggtgat     1080

gcctccccaa tcgtgaagtc ccaagagatc ttcgagaacc aagattcctc tgtcttccaa     1140

ttggtcggta agaaccatga cgaaatcgtc aacgacccaa agaaggacgt tcttgttttg     1200

tactatgccc catggtgtgg tcactgtaag agattggccc caacttacca agaactagct     1260

gatacctacg ccaacgccac atccgacgtt ttgattgcta aactagacca cactgaaaac     1320

gatgtcagag gcgtcgtaat tgaaggttac ccaacaatcg tcttataccc aggtggtaag     1380

aagtccgaat ctgttgtgta ccaaggttca agatccttgg actctttatt cgacttcatc     1440

aaggaaaacg gtcacttcga cgtcgacggt aaggccttgt acgaagaagc ccaggaaaaa     1500

gctgctgagg aagccgatgc tgacgctgaa ttggctgacg aagaagatgc cattcacgat     1560

gaattgtaa                                                             1569


<210>  9
<211>  522
<212>  PRT
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  9

Met Lys Phe Ser Ala Gly Ala Val Leu Ser Trp Ser Ser Leu Leu Leu 
1               5                   10                  15      


Ala Ser Ser Val Phe Ala Gln Gln Glu Ala Val Ala Pro Glu Asp Ser 
            20                  25                  30          


Ala Val Val Lys Leu Ala Thr Asp Ser Phe Asn Glu Tyr Ile Gln Ser 
        35                  40                  45              


His Asp Leu Val Leu Ala Glu Phe Phe Ala Pro Trp Cys Gly His Cys 
    50                  55                  60                  


Lys Asn Met Ala Pro Glu Tyr Val Lys Ala Ala Glu Thr Leu Val Glu 
65                  70                  75                  80  


Lys Asn Ile Thr Leu Ala Gln Ile Asp Cys Thr Glu Asn Gln Asp Leu 
                85                  90                  95      


Cys Met Glu His Asn Ile Pro Gly Phe Pro Ser Leu Lys Ile Phe Lys 
            100                 105                 110         


Asn Ser Asp Val Asn Asn Ser Ile Asp Tyr Glu Gly Pro Arg Thr Ala 
        115                 120                 125             


Glu Ala Ile Val Gln Phe Met Ile Lys Gln Ser Gln Pro Ala Val Ala 
    130                 135                 140                 


Val Val Ala Asp Leu Pro Ala Tyr Leu Ala Asn Glu Thr Phe Val Thr 
145                 150                 155                 160 


Pro Val Ile Val Gln Ser Gly Lys Ile Asp Ala Asp Phe Asn Ala Thr 
                165                 170                 175     


Phe Tyr Ser Met Ala Asn Lys His Phe Asn Asp Tyr Asp Phe Val Ser 
            180                 185                 190         


Ala Glu Asn Ala Asp Asp Asp Phe Lys Leu Ser Ile Tyr Leu Pro Ser 
        195                 200                 205             


Ala Met Asp Glu Pro Val Val Tyr Asn Gly Lys Lys Ala Asp Ile Ala 
    210                 215                 220                 


Asp Ala Asp Val Phe Glu Lys Trp Leu Gln Val Glu Ala Leu Pro Tyr 
225                 230                 235                 240 


Phe Gly Glu Ile Asp Gly Ser Val Phe Ala Gln Tyr Val Glu Ser Gly 
                245                 250                 255     


Leu Pro Leu Gly Tyr Leu Phe Tyr Asn Asp Glu Glu Glu Leu Glu Glu 
            260                 265                 270         


Tyr Lys Pro Leu Phe Thr Glu Leu Ala Lys Lys Asn Arg Gly Leu Met 
        275                 280                 285             


Asn Phe Val Ser Ile Asp Ala Arg Lys Phe Gly Arg His Ala Gly Asn 
    290                 295                 300                 


Leu Asn Met Lys Glu Gln Phe Pro Leu Phe Ala Ile His Asp Met Thr 
305                 310                 315                 320 


Glu Asp Leu Lys Tyr Gly Leu Pro Gln Leu Ser Glu Glu Ala Phe Asp 
                325                 330                 335     


Glu Leu Ser Asp Lys Ile Val Leu Glu Ser Lys Ala Ile Glu Ser Leu 
            340                 345                 350         


Val Lys Asp Phe Leu Lys Gly Asp Ala Ser Pro Ile Val Lys Ser Gln 
        355                 360                 365             


Glu Ile Phe Glu Asn Gln Asp Ser Ser Val Phe Gln Leu Val Gly Lys 
    370                 375                 380                 


Asn His Asp Glu Ile Val Asn Asp Pro Lys Lys Asp Val Leu Val Leu 
385                 390                 395                 400 


Tyr Tyr Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala Pro Thr Tyr 
                405                 410                 415     


Gln Glu Leu Ala Asp Thr Tyr Ala Asn Ala Thr Ser Asp Val Leu Ile 
            420                 425                 430         


Ala Lys Leu Asp His Thr Glu Asn Asp Val Arg Gly Val Val Ile Glu 
        435                 440                 445             


Gly Tyr Pro Thr Ile Val Leu Tyr Pro Gly Gly Lys Lys Ser Glu Ser 
    450                 455                 460                 


Val Val Tyr Gln Gly Ser Arg Ser Leu Asp Ser Leu Phe Asp Phe Ile 
465                 470                 475                 480 


Lys Glu Asn Gly His Phe Asp Val Asp Gly Lys Ala Leu Tyr Glu Glu 
                485                 490                 495     


Ala Gln Glu Lys Ala Ala Glu Glu Ala Asp Ala Asp Ala Glu Leu Ala 
            500                 505                 510         


Asp Glu Glu Asp Ala Ile His Asp Glu Leu 
        515                 520         


<210>  10
<211>  3348
<212>  DNA
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  10
atgcgtctac ttcgaagaaa catgttagta ttgacactgc tcgtttgtgt gttttcatcc       60

atcatttcat gctcaatccc attgtcgtct cgcacctcaa ggcggcagat agtggaagat      120

gaagttgcct ccactaaaaa gctcaatttc aactatggtg tggataaaaa tataaactcg      180

cccattcctg ctccaagaac cactgaaggt ttaccaaata tgaaactcag ctcatatcca      240

actcctaact tattgaatac tgctgataat cgacgtgcta acaaaaaagg acgtagggct      300

gccaattcta taagtgtacc ctatttggag aatcgttcct tgaacgaact gagtttatca      360

gatatactaa tcgcagccga cgttgagggt ggacttcatg ctgtagatag aagaaatggt      420

catatcatat ggtcaatcga accagaaaat tttcaacctc tgatagaaat acaagaacct      480

tcgaggttag aaacatatga aacgttgatt atagaacctt tcggtgatgg gaacatttac      540

tactttaacg cccatcaagg gttacaaaaa ctgcctttat ccatacgaca acttgtatca      600

acttccccgc tgcacttgaa aacaaatatt gtggttaatg actctggaaa aattgttgaa      660

gatgaaaagg tctacactgg atcgatgaga actataatgt atactataaa catgttgaat      720

ggtgaaatta tatcagcgtt cggacctggt tcaaaaaacg ggtatttcgg gagccagagt      780

gtggattgct cacctgagga gaagataaaa cttcaggaat gtgaaaatat gattgtaata      840

ggcaaaacta tttttgagct gggaattcac tcttatgatg gagcaagcta caatgtcact      900

tactctacat ggcagcaaaa tgttttagat gttcccctag cgcttcagaa tacattttca      960

aaggacggca tgtgcatagc gcctttccgt gataaatcat tgctagcaag cgatttagat     1020

tttagaattg ctagatgggt ttctccgaca ttccccggaa ttattgttgg gcttttcgat     1080

gtgtttaatg atctccgcac caatgaaaat atactggtac cgcatccctt taatcctggt     1140

gatcatgaaa gtatatcgag taacaaagtt tacttggatc agacttcgaa cctctcctgg     1200

tttgcattat ctagtcagaa ttttccatct ttagtcgaat cagctcccat atcaagatac     1260

gcttccagtg accgttggag ggtgtcttca atttttgaag atgagacttt attcaagaac     1320

gcaatcatgg gtgttcatca gatatataat aatgaatatg atcaccttta tgaaaactat     1380

gaaaaaacga atagtttgga cactacgcac aaatatccac ctctgatgat tgattcgtcc     1440

gttgatacaa ccgatttaca tcagaataac gagatgaatt cactaaagga atacatgtca     1500

ccagaagacc ttgaggcata tagaaaaaag atacacgagc aaatatcgag agaattagat     1560

gaaaagaacc aaaattcttt gctactgaag tttggaagtc tagtatatcg aattatagag     1620

actggagtat ttctgttgtt atttctcatt ttttgtgcaa tactacaaag attcaaaatt     1680

ttgccgccac tatatgtatt attatccaaa attggattta tgcctgaaaa ggaaatcccc     1740

atagttgagt cgaaatcgct aaattgtccc tcttcatcgg aaaatgtaac caagccattc     1800

gatatgaaat cagggaagca agttgttttt gaaggtgctg tgaacgatgg aagtctaaaa     1860

tctgaaaaag ataacgatga tgctgatgaa gatgatgaaa aatcactaga tttaaccaca     1920

gaaaagaaga agaggaaaag aggttcgaga ggaggcaaaa agggccgaaa atcacgcatt     1980

gcaaatatac caaactttga gcaatcttta aaaaatttgg tagtatccga aaaaatttta     2040

ggttacggtt catcaggaac agtagttttt cagggaagtt ttcaaggaag acctgttgcg     2100

gtaaagagaa tgttaattga tttttgtgac atagctttaa tggaaataaa acttttgact     2160

gaaagcgatg atcaccctaa cgtcatacga tactactgtt cagaaacaac agacagattt     2220

ttgtatattg ctttagagct ctgcaatttg aaccttcaag atttggtgga gtctaagaat     2280

gtatcagatg aaaacctgaa attacagaaa gagtataatc caatttcgtt attgagacaa     2340

atagcgtccg gggtagcaca tttacattct ttaaagatta tccatcgaga tttaaagcct     2400

caaaatattc tcgtttctac ttcgagtagg tttactgccg atcagcaaac aggagcagaa     2460

aatcttcgaa ttttgatatc agactttggt ctttgcaaaa aactagactc tggtcagtct     2520

tcatttagaa caaatttgaa taacccttct ggcacaagtg gttggagggc cccagagctg     2580

cttgaagaat caaacaattt gcagtgccaa gtcgaaacgg aacactcttc tagtaggcat     2640

acagtagttt catctgattc tttttatgat ccgttcacca agaggaggct aacaagatct     2700

attgatattt tttctatggg atgtgtattc tattatatcc tatccaaagg gaagcatcca     2760

tttggagata aatattcacg tgaaagcaat atcataagag gaatattcag tcttgatgaa     2820

atgaaatgtc tacatgatag atccttaatt gcagaagcta cagatctgat ctcccaaatg     2880

attgatcacg atccgttaaa aagacctact gctatgaaag ttctaaggca tccgttgttt     2940

tggccaaagt cgaaaaaatt ggagttcctt ttaaaagtta gtgataggct tgaaattgaa     3000

aacagagacc ctccaagtgc cctgttaatg aaatttgacg ccggttctga ctttgtaata     3060

cccagtggag attggactgt caagtttgat aaaacattca tggacaacct tgaaaggtac     3120

agaaaatacc attcatcaaa gttaatggat ctattaagag cacttaggaa taaatatcat     3180

cattttatgg atttacctga agatatagca gaactaatgg ggccggtacc cgatggattt     3240

tacgattact tcaccaagcg ttttccaaac ctattaatag gtgtttatat gattgtcaag     3300

gaaaatttaa gtgacgatca aattttacgt gaatttttgt attcataa                  3348


<210>  11
<211>  1115
<212>  PRT
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  11

Met Arg Leu Leu Arg Arg Asn Met Leu Val Leu Thr Leu Leu Val Cys 
1               5                   10                  15      


Val Phe Ser Ser Ile Ile Ser Cys Ser Ile Pro Leu Ser Ser Arg Thr 
            20                  25                  30          


Ser Arg Arg Gln Ile Val Glu Asp Glu Val Ala Ser Thr Lys Lys Leu 
        35                  40                  45              


Asn Phe Asn Tyr Gly Val Asp Lys Asn Ile Asn Ser Pro Ile Pro Ala 
    50                  55                  60                  


Pro Arg Thr Thr Glu Gly Leu Pro Asn Met Lys Leu Ser Ser Tyr Pro 
65                  70                  75                  80  


Thr Pro Asn Leu Leu Asn Thr Ala Asp Asn Arg Arg Ala Asn Lys Lys 
                85                  90                  95      


Gly Arg Arg Ala Ala Asn Ser Ile Ser Val Pro Tyr Leu Glu Asn Arg 
            100                 105                 110         


Ser Leu Asn Glu Leu Ser Leu Ser Asp Ile Leu Ile Ala Ala Asp Val 
        115                 120                 125             


Glu Gly Gly Leu His Ala Val Asp Arg Arg Asn Gly His Ile Ile Trp 
    130                 135                 140                 


Ser Ile Glu Pro Glu Asn Phe Gln Pro Leu Ile Glu Ile Gln Glu Pro 
145                 150                 155                 160 


Ser Arg Leu Glu Thr Tyr Glu Thr Leu Ile Ile Glu Pro Phe Gly Asp 
                165                 170                 175     


Gly Asn Ile Tyr Tyr Phe Asn Ala His Gln Gly Leu Gln Lys Leu Pro 
            180                 185                 190         


Leu Ser Ile Arg Gln Leu Val Ser Thr Ser Pro Leu His Leu Lys Thr 
        195                 200                 205             


Asn Ile Val Val Asn Asp Ser Gly Lys Ile Val Glu Asp Glu Lys Val 
    210                 215                 220                 


Tyr Thr Gly Ser Met Arg Thr Ile Met Tyr Thr Ile Asn Met Leu Asn 
225                 230                 235                 240 


Gly Glu Ile Ile Ser Ala Phe Gly Pro Gly Ser Lys Asn Gly Tyr Phe 
                245                 250                 255     


Gly Ser Gln Ser Val Asp Cys Ser Pro Glu Glu Lys Ile Lys Leu Gln 
            260                 265                 270         


Glu Cys Glu Asn Met Ile Val Ile Gly Lys Thr Ile Phe Glu Leu Gly 
        275                 280                 285             


Ile His Ser Tyr Asp Gly Ala Ser Tyr Asn Val Thr Tyr Ser Thr Trp 
    290                 295                 300                 


Gln Gln Asn Val Leu Asp Val Pro Leu Ala Leu Gln Asn Thr Phe Ser 
305                 310                 315                 320 


Lys Asp Gly Met Cys Ile Ala Pro Phe Arg Asp Lys Ser Leu Leu Ala 
                325                 330                 335     


Ser Asp Leu Asp Phe Arg Ile Ala Arg Trp Val Ser Pro Thr Phe Pro 
            340                 345                 350         


Gly Ile Ile Val Gly Leu Phe Asp Val Phe Asn Asp Leu Arg Thr Asn 
        355                 360                 365             


Glu Asn Ile Leu Val Pro His Pro Phe Asn Pro Gly Asp His Glu Ser 
    370                 375                 380                 


Ile Ser Ser Asn Lys Val Tyr Leu Asp Gln Thr Ser Asn Leu Ser Trp 
385                 390                 395                 400 


Phe Ala Leu Ser Ser Gln Asn Phe Pro Ser Leu Val Glu Ser Ala Pro 
                405                 410                 415     


Ile Ser Arg Tyr Ala Ser Ser Asp Arg Trp Arg Val Ser Ser Ile Phe 
            420                 425                 430         


Glu Asp Glu Thr Leu Phe Lys Asn Ala Ile Met Gly Val His Gln Ile 
        435                 440                 445             


Tyr Asn Asn Glu Tyr Asp His Leu Tyr Glu Asn Tyr Glu Lys Thr Asn 
    450                 455                 460                 


Ser Leu Asp Thr Thr His Lys Tyr Pro Pro Leu Met Ile Asp Ser Ser 
465                 470                 475                 480 


Val Asp Thr Thr Asp Leu His Gln Asn Asn Glu Met Asn Ser Leu Lys 
                485                 490                 495     


Glu Tyr Met Ser Pro Glu Asp Leu Glu Ala Tyr Arg Lys Lys Ile His 
            500                 505                 510         


Glu Gln Ile Ser Arg Glu Leu Asp Glu Lys Asn Gln Asn Ser Leu Leu 
        515                 520                 525             


Leu Lys Phe Gly Ser Leu Val Tyr Arg Ile Ile Glu Thr Gly Val Phe 
    530                 535                 540                 


Leu Leu Leu Phe Leu Ile Phe Cys Ala Ile Leu Gln Arg Phe Lys Ile 
545                 550                 555                 560 


Leu Pro Pro Leu Tyr Val Leu Leu Ser Lys Ile Gly Phe Met Pro Glu 
                565                 570                 575     


Lys Glu Ile Pro Ile Val Glu Ser Lys Ser Leu Asn Cys Pro Ser Ser 
            580                 585                 590         


Ser Glu Asn Val Thr Lys Pro Phe Asp Met Lys Ser Gly Lys Gln Val 
        595                 600                 605             


Val Phe Glu Gly Ala Val Asn Asp Gly Ser Leu Lys Ser Glu Lys Asp 
    610                 615                 620                 


Asn Asp Asp Ala Asp Glu Asp Asp Glu Lys Ser Leu Asp Leu Thr Thr 
625                 630                 635                 640 


Glu Lys Lys Lys Arg Lys Arg Gly Ser Arg Gly Gly Lys Lys Gly Arg 
                645                 650                 655     


Lys Ser Arg Ile Ala Asn Ile Pro Asn Phe Glu Gln Ser Leu Lys Asn 
            660                 665                 670         


Leu Val Val Ser Glu Lys Ile Leu Gly Tyr Gly Ser Ser Gly Thr Val 
        675                 680                 685             


Val Phe Gln Gly Ser Phe Gln Gly Arg Pro Val Ala Val Lys Arg Met 
    690                 695                 700                 


Leu Ile Asp Phe Cys Asp Ile Ala Leu Met Glu Ile Lys Leu Leu Thr 
705                 710                 715                 720 


Glu Ser Asp Asp His Pro Asn Val Ile Arg Tyr Tyr Cys Ser Glu Thr 
                725                 730                 735     


Thr Asp Arg Phe Leu Tyr Ile Ala Leu Glu Leu Cys Asn Leu Asn Leu 
            740                 745                 750         


Gln Asp Leu Val Glu Ser Lys Asn Val Ser Asp Glu Asn Leu Lys Leu 
        755                 760                 765             


Gln Lys Glu Tyr Asn Pro Ile Ser Leu Leu Arg Gln Ile Ala Ser Gly 
    770                 775                 780                 


Val Ala His Leu His Ser Leu Lys Ile Ile His Arg Asp Leu Lys Pro 
785                 790                 795                 800 


Gln Asn Ile Leu Val Ser Thr Ser Ser Arg Phe Thr Ala Asp Gln Gln 
                805                 810                 815     


Thr Gly Ala Glu Asn Leu Arg Ile Leu Ile Ser Asp Phe Gly Leu Cys 
            820                 825                 830         


Lys Lys Leu Asp Ser Gly Gln Ser Ser Phe Arg Thr Asn Leu Asn Asn 
        835                 840                 845             


Pro Ser Gly Thr Ser Gly Trp Arg Ala Pro Glu Leu Leu Glu Glu Ser 
    850                 855                 860                 


Asn Asn Leu Gln Cys Gln Val Glu Thr Glu His Ser Ser Ser Arg His 
865                 870                 875                 880 


Thr Val Val Ser Ser Asp Ser Phe Tyr Asp Pro Phe Thr Lys Arg Arg 
                885                 890                 895     


Leu Thr Arg Ser Ile Asp Ile Phe Ser Met Gly Cys Val Phe Tyr Tyr 
            900                 905                 910         


Ile Leu Ser Lys Gly Lys His Pro Phe Gly Asp Lys Tyr Ser Arg Glu 
        915                 920                 925             


Ser Asn Ile Ile Arg Gly Ile Phe Ser Leu Asp Glu Met Lys Cys Leu 
    930                 935                 940                 


His Asp Arg Ser Leu Ile Ala Glu Ala Thr Asp Leu Ile Ser Gln Met 
945                 950                 955                 960 


Ile Asp His Asp Pro Leu Lys Arg Pro Thr Ala Met Lys Val Leu Arg 
                965                 970                 975     


His Pro Leu Phe Trp Pro Lys Ser Lys Lys Leu Glu Phe Leu Leu Lys 
            980                 985                 990         


Val Ser Asp Arg Leu Glu Ile Glu  Asn Arg Asp Pro Pro  Ser Ala Leu 
        995                 1000                 1005             


Leu Met  Lys Phe Asp Ala Gly  Ser Asp Phe Val Ile  Pro Ser Gly 
    1010                 1015                 1020             


Asp Trp  Thr Val Lys Phe Asp  Lys Thr Phe Met Asp  Asn Leu Glu 
    1025                 1030                 1035             


Arg Tyr  Arg Lys Tyr His Ser  Ser Lys Leu Met Asp  Leu Leu Arg 
    1040                 1045                 1050             


Ala Leu  Arg Asn Lys Tyr His  His Phe Met Asp Leu  Pro Glu Asp 
    1055                 1060                 1065             


Ile Ala  Glu Leu Met Gly Pro  Val Pro Asp Gly Phe  Tyr Asp Tyr 
    1070                 1075                 1080             


Phe Thr  Lys Arg Phe Pro Asn  Leu Leu Ile Gly Val  Tyr Met Ile 
    1085                 1090                 1095             


Val Lys  Glu Asn Leu Ser Asp  Asp Gln Ile Leu Arg  Glu Phe Leu 
    1100                 1105                 1110             


Tyr Ser  
    1115 


<210>  12
<211>  2865
<212>  DNA
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  12
atggtccttt tgaaatggct cgtatgccaa ttggtcttct ttaccgcttt ttcgcatgcg       60

tttaccgact atctattaaa gaagtgtgcg caatctgggt tttgccatag aaacagggtt      120

tatgcagaaa atattgccaa atctcatcac tgctattaca aagtggacgc cgagtctatt      180

gcacacgatc ctttagagaa tgtgcttcat gctaccataa ttaaaactat accaagattg      240

gagggcgatg atatagccgt tcagttccca ttctctctct cttttttaca ggatcactca      300

gtaaggttca ctataaatga gaaagagaga atgccaacca acagcagcgg tttgttgatc      360

tcttcacaac ggttcaatga gacctggaag tacgcattcg acaagaaatt tcaagaggag      420

gcgaacagga ccagtattcc acaattccac ttccttaagc aaaaacaaac tgtgaactca      480

ttctggtcga aaatatcttc atttttgtca ctttcaaact ccactgcaga cacatttcat      540

cttcgaaacg gtgatgtatc cgtagaaatc tttgctgaac cttttcaatt gaaagtttac      600

tggcaaaatg cgctgaaact tattgtaaac gagcaaaatt tcctgaacat tgaacatcat      660

agaactaagc aggaaaactt cgcacacgtg ctgccagaag aaacaacttt caacatgttt      720

aaggacaatt tcttgtattc aaagcatgac tctatgcctt tggggcctga atcggttgcg      780

ctagatttct ctttcatggg ttctactaat gtctacggta taccggaaca tgcgacgtcg      840

ctaaggctga tggacacttc aggtggaaag gaaccctaca ggcttttcaa cgttgatgtc      900

tttgagtaca acatcggtac cagccaacca atgtacggtt cgatcccatt catgttttca      960

tcttcgtcca catctatctt ttgggtcaat gcagctgaca cttgggtaga cataaagtat     1020

gacaccagta aaaataaaac gatgactcat tggatctccg aaaatggtgt catagatgta     1080

gtcatgtccc tggggccaga tattccaact atcattgaca aatttaccga tttgactggt     1140

agaccctttt taccgcccat ttcctctata gggtaccatc aatgtagatg gaattataat     1200

gatgagatgg acgttctcac agtggactct cagatggatg ctcatatgat tccttacgat     1260

tttatttggt tggacttgga gtatacgaac gacaaaaaat attttacttg gaagcagcac     1320

tcctttccca atccaaaaag gctgttatcc aaattaaaaa agttgggtag aaatcttgtc     1380

gtactaatcg atcctcattt aaagaaagat tatgaaatca gtgacagggt aattaatgaa     1440

aatgtagcag tcaaggatca caatggaaat gactatgtag gtcattgctg gccaggtaat     1500

tctatatgga ttgataccat aagcaaatat ggccaaaaga tttggaagtc ctttttcgaa     1560

cggtttatgg atctgccggc tgatttaact aatttattca tttggaatga tatgaacgag     1620

ccttcgattt tcgatggccc agagaccaca gctccaaaag atttgattca cgacaattac     1680

attgaggaaa gatccgtcca taacatatat ggtctatcag tgcatgaagc tacttacgac     1740

gcaataaaat cgatttattc accatccgat aagcgtcctt tccttctaac aagggctttt     1800

tttgccggct ctcaacgtac tgctgccaca tggactggtg acaatgtggc caattgggat     1860

tacttaaaga tttccattcc tatggttctg tcaaacaaca ttgctggtat gccatttata     1920

ggagccgaca tagctggctt tgctgaggat cctacacctg aattgattgc acgttggtac     1980

caagcgggct tatggtaccc attttttaga gcacacgccc atatagacac caagagaaga     2040

gaaccatact tattcaatga acctttgaag tcgatagtac gtgatattat ccaattgaga     2100

tatttcctgc tacctacctt atacaccatg tttcataaat caagtgtcac tggatttccg     2160

ataatgaatc caatgtttat tgaacaccct gaatttgctg aattgtatca tatcgataac     2220

caattttact ggagtaattc aggtctatta gtcaaacctg tcacggagcc tggtcaatca     2280

gaaacggaaa tggttttccc acccggtata ttctatgaat tcgcatcttt acactctttt     2340

ataaacaatg gtactgattt gatagaaaag aatatttctg caccattgga taaaattcca     2400

ttatttattg aaggcggtca cattatcact atgaaagata agtatagaag atcttcaatg     2460

ttaatgaaaa acgatccata tgtaatagtt atagcccctg ataccgaggg acgagccgtt     2520

ggagatcttt atgttgatga tggagaaact tttggctacc aaagaggtga gtacgtagaa     2580

actcagttca ttttcgaaaa caatacctta aaaaatgttc gaagtcatat tcccgagaat     2640

ttgacaggca ttcaccacaa tactttgagg aataccaata ttgaaaaaat cattatcgca     2700

aagaataatt tacaacacaa cataacgttg aaagacagta ttaaagtcaa aaaaaatggc     2760

gaagaaagtt cattgccgac tagatcgtca tatgagaatg ataataagat caccattctt     2820

aacctatcgc ttgacataac tgaagattgg gaagttattt tttga                     2865


<210>  13
<211>  954
<212>  PRT
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  13

Met Val Leu Leu Lys Trp Leu Val Cys Gln Leu Val Phe Phe Thr Ala 
1               5                   10                  15      


Phe Ser His Ala Phe Thr Asp Tyr Leu Leu Lys Lys Cys Ala Gln Ser 
            20                  25                  30          


Gly Phe Cys His Arg Asn Arg Val Tyr Ala Glu Asn Ile Ala Lys Ser 
        35                  40                  45              


His His Cys Tyr Tyr Lys Val Asp Ala Glu Ser Ile Ala His Asp Pro 
    50                  55                  60                  


Leu Glu Asn Val Leu His Ala Thr Ile Ile Lys Thr Ile Pro Arg Leu 
65                  70                  75                  80  


Glu Gly Asp Asp Ile Ala Val Gln Phe Pro Phe Ser Leu Ser Phe Leu 
                85                  90                  95      


Gln Asp His Ser Val Arg Phe Thr Ile Asn Glu Lys Glu Arg Met Pro 
            100                 105                 110         


Thr Asn Ser Ser Gly Leu Leu Ile Ser Ser Gln Arg Phe Asn Glu Thr 
        115                 120                 125             


Trp Lys Tyr Ala Phe Asp Lys Lys Phe Gln Glu Glu Ala Asn Arg Thr 
    130                 135                 140                 


Ser Ile Pro Gln Phe His Phe Leu Lys Gln Lys Gln Thr Val Asn Ser 
145                 150                 155                 160 


Phe Trp Ser Lys Ile Ser Ser Phe Leu Ser Leu Ser Asn Ser Thr Ala 
                165                 170                 175     


Asp Thr Phe His Leu Arg Asn Gly Asp Val Ser Val Glu Ile Phe Ala 
            180                 185                 190         


Glu Pro Phe Gln Leu Lys Val Tyr Trp Gln Asn Ala Leu Lys Leu Ile 
        195                 200                 205             


Val Asn Glu Gln Asn Phe Leu Asn Ile Glu His His Arg Thr Lys Gln 
    210                 215                 220                 


Glu Asn Phe Ala His Val Leu Pro Glu Glu Thr Thr Phe Asn Met Phe 
225                 230                 235                 240 


Lys Asp Asn Phe Leu Tyr Ser Lys His Asp Ser Met Pro Leu Gly Pro 
                245                 250                 255     


Glu Ser Val Ala Leu Asp Phe Ser Phe Met Gly Ser Thr Asn Val Tyr 
            260                 265                 270         


Gly Ile Pro Glu His Ala Thr Ser Leu Arg Leu Met Asp Thr Ser Gly 
        275                 280                 285             


Gly Lys Glu Pro Tyr Arg Leu Phe Asn Val Asp Val Phe Glu Tyr Asn 
    290                 295                 300                 


Ile Gly Thr Ser Gln Pro Met Tyr Gly Ser Ile Pro Phe Met Phe Ser 
305                 310                 315                 320 


Ser Ser Ser Thr Ser Ile Phe Trp Val Asn Ala Ala Asp Thr Trp Val 
                325                 330                 335     


Asp Ile Lys Tyr Asp Thr Ser Lys Asn Lys Thr Met Thr His Trp Ile 
            340                 345                 350         


Ser Glu Asn Gly Val Ile Asp Val Val Met Ser Leu Gly Pro Asp Ile 
        355                 360                 365             


Pro Thr Ile Ile Asp Lys Phe Thr Asp Leu Thr Gly Arg Pro Phe Leu 
    370                 375                 380                 


Pro Pro Ile Ser Ser Ile Gly Tyr His Gln Cys Arg Trp Asn Tyr Asn 
385                 390                 395                 400 


Asp Glu Met Asp Val Leu Thr Val Asp Ser Gln Met Asp Ala His Met 
                405                 410                 415     


Ile Pro Tyr Asp Phe Ile Trp Leu Asp Leu Glu Tyr Thr Asn Asp Lys 
            420                 425                 430         


Lys Tyr Phe Thr Trp Lys Gln His Ser Phe Pro Asn Pro Lys Arg Leu 
        435                 440                 445             


Leu Ser Lys Leu Lys Lys Leu Gly Arg Asn Leu Val Val Leu Ile Asp 
    450                 455                 460                 


Pro His Leu Lys Lys Asp Tyr Glu Ile Ser Asp Arg Val Ile Asn Glu 
465                 470                 475                 480 


Asn Val Ala Val Lys Asp His Asn Gly Asn Asp Tyr Val Gly His Cys 
                485                 490                 495     


Trp Pro Gly Asn Ser Ile Trp Ile Asp Thr Ile Ser Lys Tyr Gly Gln 
            500                 505                 510         


Lys Ile Trp Lys Ser Phe Phe Glu Arg Phe Met Asp Leu Pro Ala Asp 
        515                 520                 525             


Leu Thr Asn Leu Phe Ile Trp Asn Asp Met Asn Glu Pro Ser Ile Phe 
    530                 535                 540                 


Asp Gly Pro Glu Thr Thr Ala Pro Lys Asp Leu Ile His Asp Asn Tyr 
545                 550                 555                 560 


Ile Glu Glu Arg Ser Val His Asn Ile Tyr Gly Leu Ser Val His Glu 
                565                 570                 575     


Ala Thr Tyr Asp Ala Ile Lys Ser Ile Tyr Ser Pro Ser Asp Lys Arg 
            580                 585                 590         


Pro Phe Leu Leu Thr Arg Ala Phe Phe Ala Gly Ser Gln Arg Thr Ala 
        595                 600                 605             


Ala Thr Trp Thr Gly Asp Asn Val Ala Asn Trp Asp Tyr Leu Lys Ile 
    610                 615                 620                 


Ser Ile Pro Met Val Leu Ser Asn Asn Ile Ala Gly Met Pro Phe Ile 
625                 630                 635                 640 


Gly Ala Asp Ile Ala Gly Phe Ala Glu Asp Pro Thr Pro Glu Leu Ile 
                645                 650                 655     


Ala Arg Trp Tyr Gln Ala Gly Leu Trp Tyr Pro Phe Phe Arg Ala His 
            660                 665                 670         


Ala His Ile Asp Thr Lys Arg Arg Glu Pro Tyr Leu Phe Asn Glu Pro 
        675                 680                 685             


Leu Lys Ser Ile Val Arg Asp Ile Ile Gln Leu Arg Tyr Phe Leu Leu 
    690                 695                 700                 


Pro Thr Leu Tyr Thr Met Phe His Lys Ser Ser Val Thr Gly Phe Pro 
705                 710                 715                 720 


Ile Met Asn Pro Met Phe Ile Glu His Pro Glu Phe Ala Glu Leu Tyr 
                725                 730                 735     


His Ile Asp Asn Gln Phe Tyr Trp Ser Asn Ser Gly Leu Leu Val Lys 
            740                 745                 750         


Pro Val Thr Glu Pro Gly Gln Ser Glu Thr Glu Met Val Phe Pro Pro 
        755                 760                 765             


Gly Ile Phe Tyr Glu Phe Ala Ser Leu His Ser Phe Ile Asn Asn Gly 
    770                 775                 780                 


Thr Asp Leu Ile Glu Lys Asn Ile Ser Ala Pro Leu Asp Lys Ile Pro 
785                 790                 795                 800 


Leu Phe Ile Glu Gly Gly His Ile Ile Thr Met Lys Asp Lys Tyr Arg 
                805                 810                 815     


Arg Ser Ser Met Leu Met Lys Asn Asp Pro Tyr Val Ile Val Ile Ala 
            820                 825                 830         


Pro Asp Thr Glu Gly Arg Ala Val Gly Asp Leu Tyr Val Asp Asp Gly 
        835                 840                 845             


Glu Thr Phe Gly Tyr Gln Arg Gly Glu Tyr Val Glu Thr Gln Phe Ile 
    850                 855                 860                 


Phe Glu Asn Asn Thr Leu Lys Asn Val Arg Ser His Ile Pro Glu Asn 
865                 870                 875                 880 


Leu Thr Gly Ile His His Asn Thr Leu Arg Asn Thr Asn Ile Glu Lys 
                885                 890                 895     


Ile Ile Ile Ala Lys Asn Asn Leu Gln His Asn Ile Thr Leu Lys Asp 
            900                 905                 910         


Ser Ile Lys Val Lys Lys Asn Gly Glu Glu Ser Ser Leu Pro Thr Arg 
        915                 920                 925             


Ser Ser Tyr Glu Asn Asp Asn Lys Ile Thr Ile Leu Asn Leu Ser Leu 
    930                 935                 940                 


Asp Ile Thr Glu Asp Trp Glu Val Ile Phe 
945                 950                 


<210>  14
<211>  1218
<212>  DNA
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  14
atgttcagct tgaaagcatt attgccattg gccttgttgt tggtcagcgc caaccaagtt       60

gctgcaaaag tccacaaggc taaaatttat aaacacgagt tgtccgatga gatgaaagaa      120

gtcactttcg agcaacattt agctcattta ggccaaaagt acttgactca atttgagaaa      180

gctaaccccg aagttgtttt ttctagggag catcctttct tcactgaagg tggtcacgat      240

gttccattga caaattactt gaacgcacaa tattacactg acattacttt gggtactcca      300

cctcaaaact tcaaggttat tttggatact ggttcttcaa acctttgggt tccaagtaac      360

gaatgtggtt ccttggcttg tttcctacat tctaaatacg atcatgaagc ttcatcaagc      420

tacaaagcta atggtactga atttgccatt caatatggta ctggttcttt ggaaggttac      480

atttctcaag acactttgtc catcggggat ttgaccattc caaaacaaga cttcgctgag      540

gctaccagcg agccgggctt aacatttgca tttggcaagt tcgatggtat tttgggtttg      600

ggttacgata ccatttctgt tgataaggtg gtccctccat tttacaacgc cattcaacaa      660

gatttgttgg acgaaaagag atttgccttt tatttgggag acacttcaaa ggatactgaa      720

aatggcggtg aagccacctt tggtggtatt gacgagtcta agttcaaggg cgatatcact      780

tggttacctg ttcgtcgtaa ggcttactgg gaagtcaagt ttgaaggtat cggtttaggc      840

gacgagtacg ccgaattgga gagccatggt gccgccatcg atactggtac ttctttgatt      900

accttgccat caggattagc tgaaatgatt aatgctgaaa ttggggccaa gaagggttgg      960

accggtcaat atactctaga ctgtaacacc agagacaatc tacctgatct aattttcaac     1020

ttcaatggct acaacttcac tattgggcca tacgattaca cgcttgaagt ttcaggctcc     1080

tgtatctctg caattacacc aatggatttc ccagaacctg ttggcccact ggccatcgtt     1140

ggtgatgcct tcttgcgtaa atactattct atttacgatt tgggcaacaa tgcggttggt     1200

ttggccaaag caatttga                                                   1218


<210>  15
<211>  405
<212>  PRT
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  15

Met Phe Ser Leu Lys Ala Leu Leu Pro Leu Ala Leu Leu Leu Val Ser 
1               5                   10                  15      


Ala Asn Gln Val Ala Ala Lys Val His Lys Ala Lys Ile Tyr Lys His 
            20                  25                  30          


Glu Leu Ser Asp Glu Met Lys Glu Val Thr Phe Glu Gln His Leu Ala 
        35                  40                  45              


His Leu Gly Gln Lys Tyr Leu Thr Gln Phe Glu Lys Ala Asn Pro Glu 
    50                  55                  60                  


Val Val Phe Ser Arg Glu His Pro Phe Phe Thr Glu Gly Gly His Asp 
65                  70                  75                  80  


Val Pro Leu Thr Asn Tyr Leu Asn Ala Gln Tyr Tyr Thr Asp Ile Thr 
                85                  90                  95      


Leu Gly Thr Pro Pro Gln Asn Phe Lys Val Ile Leu Asp Thr Gly Ser 
            100                 105                 110         


Ser Asn Leu Trp Val Pro Ser Asn Glu Cys Gly Ser Leu Ala Cys Phe 
        115                 120                 125             


Leu His Ser Lys Tyr Asp His Glu Ala Ser Ser Ser Tyr Lys Ala Asn 
    130                 135                 140                 


Gly Thr Glu Phe Ala Ile Gln Tyr Gly Thr Gly Ser Leu Glu Gly Tyr 
145                 150                 155                 160 


Ile Ser Gln Asp Thr Leu Ser Ile Gly Asp Leu Thr Ile Pro Lys Gln 
                165                 170                 175     


Asp Phe Ala Glu Ala Thr Ser Glu Pro Gly Leu Thr Phe Ala Phe Gly 
            180                 185                 190         


Lys Phe Asp Gly Ile Leu Gly Leu Gly Tyr Asp Thr Ile Ser Val Asp 
        195                 200                 205             


Lys Val Val Pro Pro Phe Tyr Asn Ala Ile Gln Gln Asp Leu Leu Asp 
    210                 215                 220                 


Glu Lys Arg Phe Ala Phe Tyr Leu Gly Asp Thr Ser Lys Asp Thr Glu 
225                 230                 235                 240 


Asn Gly Gly Glu Ala Thr Phe Gly Gly Ile Asp Glu Ser Lys Phe Lys 
                245                 250                 255     


Gly Asp Ile Thr Trp Leu Pro Val Arg Arg Lys Ala Tyr Trp Glu Val 
            260                 265                 270         


Lys Phe Glu Gly Ile Gly Leu Gly Asp Glu Tyr Ala Glu Leu Glu Ser 
        275                 280                 285             


His Gly Ala Ala Ile Asp Thr Gly Thr Ser Leu Ile Thr Leu Pro Ser 
    290                 295                 300                 


Gly Leu Ala Glu Met Ile Asn Ala Glu Ile Gly Ala Lys Lys Gly Trp 
305                 310                 315                 320 


Thr Gly Gln Tyr Thr Leu Asp Cys Asn Thr Arg Asp Asn Leu Pro Asp 
                325                 330                 335     


Leu Ile Phe Asn Phe Asn Gly Tyr Asn Phe Thr Ile Gly Pro Tyr Asp 
            340                 345                 350         


Tyr Thr Leu Glu Val Ser Gly Ser Cys Ile Ser Ala Ile Thr Pro Met 
        355                 360                 365             


Asp Phe Pro Glu Pro Val Gly Pro Leu Ala Ile Val Gly Asp Ala Phe 
    370                 375                 380                 


Leu Arg Lys Tyr Tyr Ser Ile Tyr Asp Leu Gly Asn Asn Ala Val Gly 
385                 390                 395                 400 


Leu Ala Lys Ala Ile 
                405 


<210>  16
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Geranyl pyrophosphate olivetolic acid geranyltransferase CsPT4 
       nucleotide sequence (GOT) Codon optimized

<400>  16
atgggtttat ctttggtctg caccttctcc tttcaaacta actaccacac tttattgaat       60

ccacataata agaatcctaa gaactcttta ttgtcctacc aacacccaaa gactcctatt      120

atcaagtcct cttacgataa cttcccatct aagtactgtt tgactaagaa tttccatttg      180

ttgggtttga attctcacaa cagaatttcc tcccaatccc gttctattag agccggttct      240

gatcaaatcg aaggttcccc tcatcatgag tccgataact ccattgctac taaaatttta      300

aatttcggtc atacttgttg gaagttgcaa cgtccttacg ttgtcaaggg tatgatctct      360

attgcttgtg gtttgttcgg tagagaattg tttaacaaca gacacttgtt ctcttggggt      420

ttgatgtgga aagctttctt cgctttggtc ccaattttgt ctttcaattt cttcgccgcc      480

atcatgaacc aaatctacga tgttgatatc gaccgtatca acaagccaga cttaccttta      540

gtttccggtg aaatgtccat tgaaactgct tggatcttgt ctatcattgt tgccttgact      600

ggtttaattg ttactattaa gttgaagtcc gctccattgt ttgtcttcat ctacatcttc      660

ggtatcttcg ctggtttcgc ttactccgtc ccacctatta gatggaaaca atatcctttt      720

accaatttct tgatcactat ttcctctcat gttggtttgg ctttcacttc ttactctgcc      780

accacttctg ctttaggttt gcctttcgtt tggcgtcctg ccttctcttt cattattgct      840

ttcatgactg tcatgggtat gactattgcc tttgctaaag acatttctga tatcgaaggt      900

gatgctaagt acggtgtctc taccgttgct accaagttag gtgctagaaa tatgactttt      960

gttgtttctg gtgtcttatt gttgaactac ttggtttcta tctctattgg tatcatttgg     1020

ccacaagttt tcaagtctaa cattatgatc ttgtctcatg ctattttggc tttctgtttg     1080

atctttcaaa ctcgtgaatt agccttagcc aattatgcct ctgccccatc ccgtcaattt     1140

ttcgaattca tctggttgtt atactatgcc gaatacttcg tttacgtctt catttaa        1197


<210>  17
<211>  398
<212>  PRT
<213>  Cannibis sativa

<400>  17

Met Gly Leu Ser Leu Val Cys Thr Phe Ser Phe Gln Thr Asn Tyr His 
1               5                   10                  15      


Thr Leu Leu Asn Pro His Asn Lys Asn Pro Lys Asn Ser Leu Leu Ser 
            20                  25                  30          


Tyr Gln His Pro Lys Thr Pro Ile Ile Lys Ser Ser Tyr Asp Asn Phe 
        35                  40                  45              


Pro Ser Lys Tyr Cys Leu Thr Lys Asn Phe His Leu Leu Gly Leu Asn 
    50                  55                  60                  


Ser His Asn Arg Ile Ser Ser Gln Ser Arg Ser Ile Arg Ala Gly Ser 
65                  70                  75                  80  


Asp Gln Ile Glu Gly Ser Pro His His Glu Ser Asp Asn Ser Ile Ala 
                85                  90                  95      


Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln Arg Pro 
            100                 105                 110         


Tyr Val Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe Gly Arg 
        115                 120                 125             


Glu Leu Phe Asn Asn Arg His Leu Phe Ser Trp Gly Leu Met Trp Lys 
    130                 135                 140                 


Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe Ala Ala 
145                 150                 155                 160 


Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn Lys Pro 
                165                 170                 175     


Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala Trp Ile 
            180                 185                 190         


Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile Lys Leu 
        195                 200                 205             


Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile Phe Ala 
    210                 215                 220                 


Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Tyr Pro Phe 
225                 230                 235                 240 


Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala Phe Thr 
                245                 250                 255     


Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe Val Trp Arg 
            260                 265                 270         


Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val Met Gly Met Thr 
        275                 280                 285             


Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala Lys Tyr 
    290                 295                 300                 


Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met Thr Phe 
305                 310                 315                 320 


Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val Ser Ile Ser Ile 
                325                 330                 335     


Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile Met Ile Leu Ser 
            340                 345                 350         


His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu Leu Ala 
        355                 360                 365             


Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu Phe Ile 
    370                 375                 380                 


Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
385                 390                 395             


<210>  18
<211>  1158
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Tetraketide synthase (TKS) nucleotide sequence Codon optimized

<400>  18
atgaaccatt taagagctga gggtccagct tccgtcttgg ctatcggtac tgctaatcca       60

gagaacattt tattacaaga tgagtttcca gattactatt tccgtgttac taagtccgag      120

catatgaccc aattgaaaga aaagttccgt aaaatctgtg ataaatctat gattagaaaa      180

agaaactgct ttttaaacga agaacacttg aagcaaaacc caagattagt tgaacacgag      240

atgcaaacct tggacgctag acaagatatg ttggttgtcg aggttcctaa attgggtaaa      300

gacgcctgtg ctaaagctat caaagagtgg ggtcaaccta agtccaagat cactcactta      360

atcttcactt ccgcttccac cactgacatg cctggtgctg attaccactg tgccaagttg      420

ttgggtttgt ctccttctgt caagagagtt atgatgtacc aattaggttg ttacggtggt      480

ggtactgtct taagaattgc taaggacatc gctgaaaaca acaaaggtgc tagagtttta      540

gccgtttgtt gtgacatcat ggcttgttta tttcgtggtc catctgaatc tgacttggag      600

ttgttggttg gtcaagctat ttttggtgat ggtgccgctg ccgtcatcgt tggtgctgag      660

ccagatgaat ccgttggtga aagaccaatt ttcgaattag tctctactgg tcaaactatt      720

ttgccaaact ccgagggtac tatcggtggt catattcgtg aagccggttt aatctttgat      780

ttgcacaaag acgttccaat gttgatctct aacaacatcg aaaagtgttt aattgaggct      840

tttactccaa ttggtatctc tgactggaac tctatcttct ggatcactca tccaggtggt      900

aaggctatct tggacaaggt tgaagaaaaa ttacatttaa agtccgataa attcgtcgat      960

tctcgtcatg ttttgtctga acacggtaac atgtcttcct ccactgtctt gtttgttatg     1020

gatgaattac gtaagagatc tttggaggag ggtaagtcta ctactggtga tggtttcgaa     1080

tggggtgttt tgttcggttt cggtcctggt ttgactgttg aacgtgttgt tgttagatct     1140

gttccaatta agtactag                                                   1158


<210>  19
<211>  385
<212>  PRT
<213>  Cannabis sativa

<400>  19

Met Asn His Leu Arg Ala Glu Gly Pro Ala Ser Val Leu Ala Ile Gly 
1               5                   10                  15      


Thr Ala Asn Pro Glu Asn Ile Leu Leu Gln Asp Glu Phe Pro Asp Tyr 
            20                  25                  30          


Tyr Phe Arg Val Thr Lys Ser Glu His Met Thr Gln Leu Lys Glu Lys 
        35                  40                  45              


Phe Arg Lys Ile Cys Asp Lys Ser Met Ile Arg Lys Arg Asn Cys Phe 
    50                  55                  60                  


Leu Asn Glu Glu His Leu Lys Gln Asn Pro Arg Leu Val Glu His Glu 
65                  70                  75                  80  


Met Gln Thr Leu Asp Ala Arg Gln Asp Met Leu Val Val Glu Val Pro 
                85                  90                  95      


Lys Leu Gly Lys Asp Ala Cys Ala Lys Ala Ile Lys Glu Trp Gly Gln 
            100                 105                 110         


Pro Lys Ser Lys Ile Thr His Leu Ile Phe Thr Ser Ala Ser Thr Thr 
        115                 120                 125             


Asp Met Pro Gly Ala Asp Tyr His Cys Ala Lys Leu Leu Gly Leu Ser 
    130                 135                 140                 


Pro Ser Val Lys Arg Val Met Met Tyr Gln Leu Gly Cys Tyr Gly Gly 
145                 150                 155                 160 


Gly Thr Val Leu Arg Ile Ala Lys Asp Ile Ala Glu Asn Asn Lys Gly 
                165                 170                 175     


Ala Arg Val Leu Ala Val Cys Cys Asp Ile Met Ala Cys Leu Phe Arg 
            180                 185                 190         


Gly Pro Ser Glu Ser Asp Leu Glu Leu Leu Val Gly Gln Ala Ile Phe 
        195                 200                 205             


Gly Asp Gly Ala Ala Ala Val Ile Val Gly Ala Glu Pro Asp Glu Ser 
    210                 215                 220                 


Val Gly Glu Arg Pro Ile Phe Glu Leu Val Ser Thr Gly Gln Thr Ile 
225                 230                 235                 240 


Leu Pro Asn Ser Glu Gly Thr Ile Gly Gly His Ile Arg Glu Ala Gly 
                245                 250                 255     


Leu Ile Phe Asp Leu His Lys Asp Val Pro Met Leu Ile Ser Asn Asn 
            260                 265                 270         


Ile Glu Lys Cys Leu Ile Glu Ala Phe Thr Pro Ile Gly Ile Ser Asp 
        275                 280                 285             


Trp Asn Ser Ile Phe Trp Ile Thr His Pro Gly Gly Lys Ala Ile Leu 
    290                 295                 300                 


Asp Lys Val Glu Glu Lys Leu His Leu Lys Ser Asp Lys Phe Val Asp 
305                 310                 315                 320 


Ser Arg His Val Leu Ser Glu His Gly Asn Met Ser Ser Ser Thr Val 
                325                 330                 335     


Leu Phe Val Met Asp Glu Leu Arg Lys Arg Ser Leu Glu Glu Gly Lys 
            340                 345                 350         


Ser Thr Thr Gly Asp Gly Phe Glu Trp Gly Val Leu Phe Gly Phe Gly 
        355                 360                 365             


Pro Gly Leu Thr Val Glu Arg Val Val Val Arg Ser Val Pro Ile Lys 
    370                 375                 380                 


Tyr 
385 


<210>  20
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Olivetolic acid cyclase (OAC) nucleotide sequence Codon optimized

<400>  20
atggccgtca aacacttgat cgtcttaaaa ttcaaggatg aaattactga agctcaaaaa       60

gaagagttct tcaaaaccta tgtcaattta gtcaacatta ttcctgctat gaaggacgtt      120

tactggggta aggatgtcac ccaaaagaac aaggaagaag gttacactca cattgttgaa      180

gtcactttcg aatctgttga aactatccaa gattatatta tccacccagc tcatgtcggt      240

tttggtgatg tttacagatc tttttgggaa aaattgttga tctttgacta tactccaaga      300

aaataa                                                                 306


<210>  21
<211>  101
<212>  PRT
<213>  Cannabis sativa

<400>  21

Met Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr 
1               5                   10                  15      


Glu Ala Gln Lys Glu Glu Phe Phe Lys Thr Tyr Val Asn Leu Val Asn 
            20                  25                  30          


Ile Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr Gln 
        35                  40                  45              


Lys Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu 
    50                  55                  60                  


Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly 
65                  70                  75                  80  


Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp 
                85                  90                  95      


Tyr Thr Pro Arg Lys 
            100     


<210>  22
<211>  2163
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Acyl-activating enzyme Cs_AAE1 nucleotide sequence Codon optimized

<400>  22
atgggtaaga attacaagtc cttagactct gttgttgctt ctgactttat tgctttaggt       60

attacttccg aagttgctga aaccttacac ggtagattgg ctgaaattgt ttgcaactac      120

ggtgctgcta cccctcaaac ttggattaac attgctaatc atattttgtc tccagatttg      180

ccattttctt tacaccaaat gttgttctac ggttgttaca aggatttcgg tcctgctcct      240

ccagcttgga ttcctgatcc agaaaaagtc aaatctacta acttgggtgc tttgttggaa      300

aagagaggta aggagttttt gggtgttaag tacaaggacc caatttcttc tttctctcac      360

ttccaagaat tctctgttag aaaccctgaa gtttactgga gaactgtttt gatggatgag      420

atgaagattt ctttttctaa ggacccagag tgtatcttaa gaagagacga cattaacaat      480

ccaggtggtt ctgagtggtt accaggtggt tacttgaact ctgccaaaaa ttgcttgaac      540

gttaactcta acaagaaatt gaatgacact atgattgtct ggagagatga gggtaacgat      600

gatttgcctt tgaataaatt gactttggat caattgagaa aaagagtctg gttggttggt      660

tacgctttgg aagaaatggg tttagaaaaa ggttgtgcta tcgccatcga tatgcctatg      720

cacgttgatg ctgttgttat ttatttggct attgttttag ctggttatgt tgttgtttcc      780

atcgccgact ccttctctgc tccagaaatc tccaccagat tgagattgtc taaagccaaa      840

gccattttca cccaagacca catcattaga ggtaagaagc gtattccatt gtattctcgt      900

gttgttgaag ctaaatctcc tatggctatc gtcatcccat gctctggttc taacatcggt      960

gctgaattaa gagacggtga tatttcttgg gactactttt tagaaagagc taaagaattc     1020

aaaaactgcg agtttactgc tagagaacaa cctgtcgacg cttatactaa tattttattc     1080

tcttctggta ctactggtga acctaaggct attccatgga cccaagctac tcctttgaaa     1140

gccgctgctg atggttggtc ccatttagac atcagaaaag gtgatgtcat cgtctggcca     1200

actaacttag gttggatgat gggtccatgg ttagtctacg cttctttgtt gaatggtgcc     1260

tctatcgcct tatataatgg ttccccttta gtctctggtt ttgctaaatt cgttcaagat     1320

gctaaggtta ccatgttagg tgttgtccct tctatcgtta gatcttggaa atctactaac     1380

tgtgtttctg gttacgactg gtccactatt cgttgtttct cttcttctgg tgaagcttcc     1440

aatgtcgatg agtacttatg gttaatgggt cgtgctaact acaagccagt catcgaaatg     1500

tgcggtggta ctgaaattgg tggtgctttt tccgctggtt cttttttaca agcccaatcc     1560

ttgtcttcct tctcctctca atgtatgggt tgtactttat atatcttaga taagaatggt     1620

taccctatgc ctaaaaacaa gccaggtatt ggtgaattag ctttgggtcc tgttatgttt     1680

ggtgcttcta aaaccttgtt aaatggtaat catcacgacg tttacttcaa aggtatgcct     1740

actttgaacg gtgaggtttt gagacgtcat ggtgatattt tcgaattaac ttccaacggt     1800

tattatcacg ctcacggtag agctgatgat actatgaaca ttggtggtat taagatctct     1860

tccatcgaaa ttgagagagt ttgtaacgag gttgacgatc gtgttttcga aactactgct     1920

attggtgtcc ctcctttagg tggtggtcca gaacaattgg ttatcttttt cgtcttgaag     1980

gactccaacg acaccactat cgacttaaac caattaagat tgtctttcaa cttgggtttg     2040

caaaagaagt tgaatccatt atttaaggtt actcgtgtcg ttccattgtc ctccttgcca     2100

agaactgcta ccaacaagat tatgcgtaga gtcttgagac aacaattctc tcactttgag     2160

taa                                                                   2163


<210>  23
<211>  720
<212>  PRT
<213>  Cannabis sativa

<400>  23

Met Gly Lys Asn Tyr Lys Ser Leu Asp Ser Val Val Ala Ser Asp Phe 
1               5                   10                  15      


Ile Ala Leu Gly Ile Thr Ser Glu Val Ala Glu Thr Leu His Gly Arg 
            20                  25                  30          


Leu Ala Glu Ile Val Cys Asn Tyr Gly Ala Ala Thr Pro Gln Thr Trp 
        35                  40                  45              


Ile Asn Ile Ala Asn His Ile Leu Ser Pro Asp Leu Pro Phe Ser Leu 
    50                  55                  60                  


His Gln Met Leu Phe Tyr Gly Cys Tyr Lys Asp Phe Gly Pro Ala Pro 
65                  70                  75                  80  


Pro Ala Trp Ile Pro Asp Pro Glu Lys Val Lys Ser Thr Asn Leu Gly 
                85                  90                  95      


Ala Leu Leu Glu Lys Arg Gly Lys Glu Phe Leu Gly Val Lys Tyr Lys 
            100                 105                 110         


Asp Pro Ile Ser Ser Phe Ser His Phe Gln Glu Phe Ser Val Arg Asn 
        115                 120                 125             


Pro Glu Val Tyr Trp Arg Thr Val Leu Met Asp Glu Met Lys Ile Ser 
    130                 135                 140                 


Phe Ser Lys Asp Pro Glu Cys Ile Leu Arg Arg Asp Asp Ile Asn Asn 
145                 150                 155                 160 


Pro Gly Gly Ser Glu Trp Leu Pro Gly Gly Tyr Leu Asn Ser Ala Lys 
                165                 170                 175     


Asn Cys Leu Asn Val Asn Ser Asn Lys Lys Leu Asn Asp Thr Met Ile 
            180                 185                 190         


Val Trp Arg Asp Glu Gly Asn Asp Asp Leu Pro Leu Asn Lys Leu Thr 
        195                 200                 205             


Leu Asp Gln Leu Arg Lys Arg Val Trp Leu Val Gly Tyr Ala Leu Glu 
    210                 215                 220                 


Glu Met Gly Leu Glu Lys Gly Cys Ala Ile Ala Ile Asp Met Pro Met 
225                 230                 235                 240 


His Val Asp Ala Val Val Ile Tyr Leu Ala Ile Val Leu Ala Gly Tyr 
                245                 250                 255     


Val Val Val Ser Ile Ala Asp Ser Phe Ser Ala Pro Glu Ile Ser Thr 
            260                 265                 270         


Arg Leu Arg Leu Ser Lys Ala Lys Ala Ile Phe Thr Gln Asp His Ile 
        275                 280                 285             


Ile Arg Gly Lys Lys Arg Ile Pro Leu Tyr Ser Arg Val Val Glu Ala 
    290                 295                 300                 


Lys Ser Pro Met Ala Ile Val Ile Pro Cys Ser Gly Ser Asn Ile Gly 
305                 310                 315                 320 


Ala Glu Leu Arg Asp Gly Asp Ile Ser Trp Asp Tyr Phe Leu Glu Arg 
                325                 330                 335     


Ala Lys Glu Phe Lys Asn Cys Glu Phe Thr Ala Arg Glu Gln Pro Val 
            340                 345                 350         


Asp Ala Tyr Thr Asn Ile Leu Phe Ser Ser Gly Thr Thr Gly Glu Pro 
        355                 360                 365             


Lys Ala Ile Pro Trp Thr Gln Ala Thr Pro Leu Lys Ala Ala Ala Asp 
    370                 375                 380                 


Gly Trp Ser His Leu Asp Ile Arg Lys Gly Asp Val Ile Val Trp Pro 
385                 390                 395                 400 


Thr Asn Leu Gly Trp Met Met Gly Pro Trp Leu Val Tyr Ala Ser Leu 
                405                 410                 415     


Leu Asn Gly Ala Ser Ile Ala Leu Tyr Asn Gly Ser Pro Leu Val Ser 
            420                 425                 430         


Gly Phe Ala Lys Phe Val Gln Asp Ala Lys Val Thr Met Leu Gly Val 
        435                 440                 445             


Val Pro Ser Ile Val Arg Ser Trp Lys Ser Thr Asn Cys Val Ser Gly 
    450                 455                 460                 


Tyr Asp Trp Ser Thr Ile Arg Cys Phe Ser Ser Ser Gly Glu Ala Ser 
465                 470                 475                 480 


Asn Val Asp Glu Tyr Leu Trp Leu Met Gly Arg Ala Asn Tyr Lys Pro 
                485                 490                 495     


Val Ile Glu Met Cys Gly Gly Thr Glu Ile Gly Gly Ala Phe Ser Ala 
            500                 505                 510         


Gly Ser Phe Leu Gln Ala Gln Ser Leu Ser Ser Phe Ser Ser Gln Cys 
        515                 520                 525             


Met Gly Cys Thr Leu Tyr Ile Leu Asp Lys Asn Gly Tyr Pro Met Pro 
    530                 535                 540                 


Lys Asn Lys Pro Gly Ile Gly Glu Leu Ala Leu Gly Pro Val Met Phe 
545                 550                 555                 560 


Gly Ala Ser Lys Thr Leu Leu Asn Gly Asn His His Asp Val Tyr Phe 
                565                 570                 575     


Lys Gly Met Pro Thr Leu Asn Gly Glu Val Leu Arg Arg His Gly Asp 
            580                 585                 590         


Ile Phe Glu Leu Thr Ser Asn Gly Tyr Tyr His Ala His Gly Arg Ala 
        595                 600                 605             


Asp Asp Thr Met Asn Ile Gly Gly Ile Lys Ile Ser Ser Ile Glu Ile 
    610                 615                 620                 


Glu Arg Val Cys Asn Glu Val Asp Asp Arg Val Phe Glu Thr Thr Ala 
625                 630                 635                 640 


Ile Gly Val Pro Pro Leu Gly Gly Gly Pro Glu Gln Leu Val Ile Phe 
                645                 650                 655     


Phe Val Leu Lys Asp Ser Asn Asp Thr Thr Ile Asp Leu Asn Gln Leu 
            660                 665                 670         


Arg Leu Ser Phe Asn Leu Gly Leu Gln Lys Lys Leu Asn Pro Leu Phe 
        675                 680                 685             


Lys Val Thr Arg Val Val Pro Leu Ser Ser Leu Pro Arg Thr Ala Thr 
    690                 695                 700                 


Asn Lys Ile Met Arg Arg Val Leu Arg Gln Gln Phe Ser His Phe Glu 
705                 710                 715                 720 


<210>  24
<211>  867
<212>  DNA
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  24
atgactgccg acaacaatag tatgccccat ggtgcagtat ctagttacgc caaattagtg       60

caaaaccaaa cacctgaaga cattttggaa gagtttcctg aaattattcc attacaacaa      120

agacctaata cccgatctag tgagacgtca aatgacgaaa gcggagaaac atgtttttct      180

ggtcatgatg aggagcaaat taagttaatg aatgaaaatt gtattgtttt ggattgggac      240

gataatgcta ttggtgccgg taccaagaaa gtttgtcatt taatggaaaa tattgaaaag      300

ggtttactac atcgtgcatt ctccgtcttt attttcaatg aacaaggtga attactttta      360

caacaaagag ccactgaaaa aataactttc cctgatcttt ggactaacac atgctgctct      420

catccactat gtattgatga cgaattaggt ttgaagggta agctagacga taagattaag      480

ggcgctatta ctgcggcggt gagaaaacta gatcatgaat taggtattcc agaagatgaa      540

actaagacaa ggggtaagtt tcacttttta aacagaatcc attacatggc accaagcaat      600

gaaccatggg gtgaacatga aattgattac atcctatttt ataagatcaa cgctaaagaa      660

aacttgactg tcaacccaaa cgtcaatgaa gttagagact tcaaatgggt ttcaccaaat      720

gatttgaaaa ctatgtttgc tgacccaagt tacaagttta cgccttggtt taagattatt      780

tgcgagaatt acttattcaa ctggtgggag caattagatg acctttctga agtggaaaat      840

gacaggcaaa ttcatagaat gctataa                                          867


<210>  25
<211>  288
<212>  PRT
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  25

Met Thr Ala Asp Asn Asn Ser Met Pro His Gly Ala Val Ser Ser Tyr 
1               5                   10                  15      


Ala Lys Leu Val Gln Asn Gln Thr Pro Glu Asp Ile Leu Glu Glu Phe 
            20                  25                  30          


Pro Glu Ile Ile Pro Leu Gln Gln Arg Pro Asn Thr Arg Ser Ser Glu 
        35                  40                  45              


Thr Ser Asn Asp Glu Ser Gly Glu Thr Cys Phe Ser Gly His Asp Glu 
    50                  55                  60                  


Glu Gln Ile Lys Leu Met Asn Glu Asn Cys Ile Val Leu Asp Trp Asp 
65                  70                  75                  80  


Asp Asn Ala Ile Gly Ala Gly Thr Lys Lys Val Cys His Leu Met Glu 
                85                  90                  95      


Asn Ile Glu Lys Gly Leu Leu His Arg Ala Phe Ser Val Phe Ile Phe 
            100                 105                 110         


Asn Glu Gln Gly Glu Leu Leu Leu Gln Gln Arg Ala Thr Glu Lys Ile 
        115                 120                 125             


Thr Phe Pro Asp Leu Trp Thr Asn Thr Cys Cys Ser His Pro Leu Cys 
    130                 135                 140                 


Ile Asp Asp Glu Leu Gly Leu Lys Gly Lys Leu Asp Asp Lys Ile Lys 
145                 150                 155                 160 


Gly Ala Ile Thr Ala Ala Val Arg Lys Leu Asp His Glu Leu Gly Ile 
                165                 170                 175     


Pro Glu Asp Glu Thr Lys Thr Arg Gly Lys Phe His Phe Leu Asn Arg 
            180                 185                 190         


Ile His Tyr Met Ala Pro Ser Asn Glu Pro Trp Gly Glu His Glu Ile 
        195                 200                 205             


Asp Tyr Ile Leu Phe Tyr Lys Ile Asn Ala Lys Glu Asn Leu Thr Val 
    210                 215                 220                 


Asn Pro Asn Val Asn Glu Val Arg Asp Phe Lys Trp Val Ser Pro Asn 
225                 230                 235                 240 


Asp Leu Lys Thr Met Phe Ala Asp Pro Ser Tyr Lys Phe Thr Pro Trp 
                245                 250                 255     


Phe Lys Ile Ile Cys Glu Asn Tyr Leu Phe Asn Trp Trp Glu Gln Leu 
            260                 265                 270         


Asp Asp Leu Ser Glu Val Glu Asn Asp Arg Gln Ile His Arg Met Leu 
        275                 280                 285             


<210>  26
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Truncated 3-hydroxy-3-methyl-glutaryl-CoA reductase (tHMG1, tHMGR)

<400>  26
atgcaattgg tgaagactga agtcaccaag aagtctttta ctgctcctgt acaaaaggct       60

tctacaccag ttttaaccaa taaaacagtc atttctggat cgaaagtcaa aagtttatca      120

tctgcgcaat cgagctcatc aggaccttca tcatctagtg aggaagatga ttcccgcgat      180

attgaaagct tggataagaa aatacgtcct ttagaagaat tagaagcatt attaagtagt      240

ggaaatacaa aacaattgaa gaacaaagag gtcgctgcct tggttattca cggtaagtta      300

cctttgtacg ctttggagaa aaaattaggt gatactacga gagcggttgc ggtacgtagg      360

aaggctcttt caattttggc agaagctcct gtattagcat ctgatcgttt accatataaa      420

aattatgact acgaccgcgt atttggcgct tgttgtgaaa atgttatagg ttacatgcct      480

ttgcccgttg gtgttatagg ccccttggtt atcgatggta catcttatca tataccaatg      540

gcaactacag agggttgttt ggtagcttct gccatgcgtg gctgtaaggc aatcaatgct      600

ggcggtggtg caacaactgt tttaactaag gatggtatga caagaggccc agtagtccgt      660

ttcccaactt tgaaaagatc tggtgcctgt aagatatggt tagactcaga agagggacaa      720

aacgcaatta aaaaagcttt taactctaca tcaagatttg cacgtctgca acatattcaa      780

acttgtctag caggagattt actcttcatg agatttagaa caactactgg tgacgcaatg      840

ggtatgaata tgatttctaa gggtgtcgaa tactcattaa agcaaatggt agaagagtat      900

ggctgggaag atatggaggt tgtctccgtt tctggtaact actgtaccga caaaaaacca      960

gctgccatca actggatcga aggtcgtggt aagagtgtcg tcgcagaagc tactattcct     1020

ggtgatgttg tcagaaaagt gttaaaaagt gatgtttccg cattggttga gttgaacatt     1080

gctaagaatt tggttggatc tgcaatggct gggtctgttg gtggatttaa cgcacatgca     1140

gctaatttag tgacagctgt tttcttggca ttaggacaag atcctgcaca aaatgtcgaa     1200

agttccaact gtataacatt gatgaaagaa gtggacggtg atttgagaat ttccgtatcc     1260

atgccatcca tcgaagtagg taccatcggt ggtggtactg ttctagaacc acaaggtgcc     1320

atgttggact tattaggtgt aagaggccca catgctaccg ctcctggtac caacgcacgt     1380

caattagcaa gaatagttgc ctgtgccgtc ttggcaggtg aattatcctt atgtgctgcc     1440

ctagcagccg gccatttggt tcaaagtcat atgacccaca acaggaaacc tgctgaacca     1500

acaaaaccta acaatttgga cgccactgat ataaatcgtt tgaaagatgg gtccgtcacc     1560

tgcattaaat cctaa                                                      1575


<210>  27
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Truncated 3-hydroxy-3-methyl-glutaryl-CoA reductase (Sc_tHMG1, tHMGR)

<400>  27

Met Gln Leu Val Lys Thr Glu Val Thr Lys Lys Ser Phe Thr Ala Pro 
1               5                   10                  15      


Val Gln Lys Ala Ser Thr Pro Val Leu Thr Asn Lys Thr Val Ile Ser 
            20                  25                  30          


Gly Ser Lys Val Lys Ser Leu Ser Ser Ala Gln Ser Ser Ser Ser Gly 
        35                  40                  45              


Pro Ser Ser Ser Ser Glu Glu Asp Asp Ser Arg Asp Ile Glu Ser Leu 
    50                  55                  60                  


Asp Lys Lys Ile Arg Pro Leu Glu Glu Leu Glu Ala Leu Leu Ser Ser 
65                  70                  75                  80  


Gly Asn Thr Lys Gln Leu Lys Asn Lys Glu Val Ala Ala Leu Val Ile 
                85                  90                  95      


His Gly Lys Leu Pro Leu Tyr Ala Leu Glu Lys Lys Leu Gly Asp Thr 
            100                 105                 110         


Thr Arg Ala Val Ala Val Arg Arg Lys Ala Leu Ser Ile Leu Ala Glu 
        115                 120                 125             


Ala Pro Val Leu Ala Ser Asp Arg Leu Pro Tyr Lys Asn Tyr Asp Tyr 
    130                 135                 140                 


Asp Arg Val Phe Gly Ala Cys Cys Glu Asn Val Ile Gly Tyr Met Pro 
145                 150                 155                 160 


Leu Pro Val Gly Val Ile Gly Pro Leu Val Ile Asp Gly Thr Ser Tyr 
                165                 170                 175     


His Ile Pro Met Ala Thr Thr Glu Gly Cys Leu Val Ala Ser Ala Met 
            180                 185                 190         


Arg Gly Cys Lys Ala Ile Asn Ala Gly Gly Gly Ala Thr Thr Val Leu 
        195                 200                 205             


Thr Lys Asp Gly Met Thr Arg Gly Pro Val Val Arg Phe Pro Thr Leu 
    210                 215                 220                 


Lys Arg Ser Gly Ala Cys Lys Ile Trp Leu Asp Ser Glu Glu Gly Gln 
225                 230                 235                 240 


Asn Ala Ile Lys Lys Ala Phe Asn Ser Thr Ser Arg Phe Ala Arg Leu 
                245                 250                 255     


Gln His Ile Gln Thr Cys Leu Ala Gly Asp Leu Leu Phe Met Arg Phe 
            260                 265                 270         


Arg Thr Thr Thr Gly Asp Ala Met Gly Met Asn Met Ile Ser Lys Gly 
        275                 280                 285             


Val Glu Tyr Ser Leu Lys Gln Met Val Glu Glu Tyr Gly Trp Glu Asp 
    290                 295                 300                 


Met Glu Val Val Ser Val Ser Gly Asn Tyr Cys Thr Asp Lys Lys Pro 
305                 310                 315                 320 


Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys Ser Val Val Ala Glu 
                325                 330                 335     


Ala Thr Ile Pro Gly Asp Val Val Arg Lys Val Leu Lys Ser Asp Val 
            340                 345                 350         


Ser Ala Leu Val Glu Leu Asn Ile Ala Lys Asn Leu Val Gly Ser Ala 
        355                 360                 365             


Met Ala Gly Ser Val Gly Gly Phe Asn Ala His Ala Ala Asn Leu Val 
    370                 375                 380                 


Thr Ala Val Phe Leu Ala Leu Gly Gln Asp Pro Ala Gln Asn Val Glu 
385                 390                 395                 400 


Ser Ser Asn Cys Ile Thr Leu Met Lys Glu Val Asp Gly Asp Leu Arg 
                405                 410                 415     


Ile Ser Val Ser Met Pro Ser Ile Glu Val Gly Thr Ile Gly Gly Gly 
            420                 425                 430         


Thr Val Leu Glu Pro Gln Gly Ala Met Leu Asp Leu Leu Gly Val Arg 
        435                 440                 445             


Gly Pro His Ala Thr Ala Pro Gly Thr Asn Ala Arg Gln Leu Ala Arg 
    450                 455                 460                 


Ile Val Ala Cys Ala Val Leu Ala Gly Glu Leu Ser Leu Cys Ala Ala 
465                 470                 475                 480 


Leu Ala Ala Gly His Leu Val Gln Ser His Met Thr His Asn Arg Lys 
                485                 490                 495     


Pro Ala Glu Pro Thr Lys Pro Asn Asn Leu Asp Ala Thr Asp Ile Asn 
            500                 505                 510         


Arg Leu Lys Asp Gly Ser Val Thr Cys Ile Lys Ser 
        515                 520                 


<210>  28
<211>  1387
<212>  DNA
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  28
atgactgaac taaaaaaaca aaagaccgct gaacaaaaaa ccagacctca aaatgtcggt       60

attaaaggta tccaaattta catcccaact caatgtgtca accaatctga gctagagaaa      120

tttgatggcg tttctcaagg taaatacaca attggtctgg gccaaaccaa catgtctttt      180

gtcaatgaca gagaagatat ctactcgatg tccctaactg ttttgtctaa gttgatcaag      240

agttacaaca tcgacaccaa caaaattggt agattagaag tcggtactga aactctgatt      300

gacaagtcca agtctgtcaa gtctgtcttg atgcaattgt ttggtgaaaa cactgacgtc      360

gaaggtattg acacgcttaa tgcctgttac ggtggtacca acgcgttgtt caactctttg      420

aactggattg aatctaacgc atgggatggt agagacgcca ttgtagtttg cggtgatatt      480

gccatctacg ataagggtgc cgcaagacca accggtggtg ccggtactgt tgctatgtgg      540

atcggtcctg atgctccaat tgtatttgac tctgtaagag cttcttacat ggaacacgcc      600

tacgattttt acaagccaga tttcaccagc gaatatcctt acgtcgatgg tcatttttca      660

ttaacttgtt acgtcaaggc tcttgatcaa gtttacaaga gttattccaa gaaggctatt      720

tctaaagggt tggttagcga tcccgctggt tcggatgctt tgaacgtttt gaaatatttc      780

gactacaacg ttttccatgt tccaacctgt aaattggtca caaaatcata cggtagatta      840

ctatataacg atttcagagc caatcctcaa ttgttcccag aagttgacgc cgaattagct      900

actcgcgatt atgacgaatc tttaaccgat aagaacattg aaaaaacttt tgttaatgtt      960

gctaagccat tccacaaaga gagagttgcc caatctttga ttgttccaac aaacacaggt     1020

aacatgtaca ccgcatctgt ttatgccgcc tttgcatctc tattaaacta tgttggatct     1080

gacgacttac aaggcaagcg tgttggttta ttttcttacg gttccggttt agctgcatct     1140

ctatattctt gcaaaattgt tggtgacgtc caacatatta tcaaggaatt agatattact     1200

aacaaattag ccaagagaat caccgaaact ccaaaggatt acgaagctgc catcgaattg     1260

agagaaaatg cccatttgaa gaagaacttc aaacctcaag gttccattga gcatttgcaa     1320

agtggtgttt actacttgac caacatcgat gacaaattta gaagatctta cgatgttaaa     1380

aaataat                                                               1387


<210>  29
<211>  461
<212>  PRT
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  29

Met Thr Glu Leu Lys Lys Gln Lys Thr Ala Glu Gln Lys Thr Arg Pro 
1               5                   10                  15      


Gln Asn Val Gly Ile Lys Gly Ile Gln Ile Tyr Ile Pro Thr Gln Cys 
            20                  25                  30          


Val Asn Gln Ser Glu Leu Glu Lys Phe Asp Gly Val Ser Gln Gly Lys 
        35                  40                  45              


Tyr Thr Ile Gly Leu Gly Gln Thr Asn Met Ser Phe Val Asn Asp Arg 
    50                  55                  60                  


Glu Asp Ile Tyr Ser Met Ser Leu Thr Val Leu Ser Lys Leu Ile Lys 
65                  70                  75                  80  


Ser Tyr Asn Ile Asp Thr Asn Lys Ile Gly Arg Leu Glu Val Gly Thr 
                85                  90                  95      


Glu Thr Leu Ile Asp Lys Ser Lys Ser Val Lys Ser Val Leu Met Gln 
            100                 105                 110         


Leu Phe Gly Glu Asn Thr Asp Val Glu Gly Ile Asp Thr Leu Asn Ala 
        115                 120                 125             


Cys Tyr Gly Gly Thr Asn Ala Leu Phe Asn Ser Leu Asn Trp Ile Glu 
    130                 135                 140                 


Ser Asn Ala Trp Asp Gly Arg Asp Ala Ile Val Val Cys Gly Asp Ile 
145                 150                 155                 160 


Ala Ile Tyr Asp Lys Gly Ala Ala Arg Pro Thr Gly Gly Ala Gly Thr 
                165                 170                 175     


Val Ala Met Trp Ile Gly Pro Asp Ala Pro Ile Val Phe Asp Ser Val 
            180                 185                 190         


Arg Ala Ser Tyr Met Glu His Ala Tyr Asp Phe Tyr Lys Pro Asp Phe 
        195                 200                 205             


Thr Ser Glu Tyr Pro Tyr Val Asp Gly His Phe Ser Leu Thr Cys Tyr 
    210                 215                 220                 


Val Lys Ala Leu Asp Gln Val Tyr Lys Ser Tyr Ser Lys Lys Ala Ile 
225                 230                 235                 240 


Ser Lys Gly Leu Val Ser Asp Pro Ala Gly Ser Asp Ala Leu Asn Val 
                245                 250                 255     


Leu Lys Tyr Phe Asp Tyr Asn Val Phe His Val Pro Thr Cys Lys Leu 
            260                 265                 270         


Val Thr Lys Ser Tyr Gly Arg Leu Leu Tyr Asn Asp Phe Arg Ala Asn 
        275                 280                 285             


Pro Gln Leu Phe Pro Glu Val Asp Ala Glu Leu Ala Thr Arg Asp Tyr 
    290                 295                 300                 


Asp Glu Ser Leu Thr Asp Lys Asn Ile Glu Lys Thr Phe Val Asn Val 
305                 310                 315                 320 


Ala Lys Pro Phe His Lys Glu Arg Val Ala Gln Ser Leu Ile Val Pro 
                325                 330                 335     


Thr Asn Thr Gly Asn Met Tyr Thr Ala Ser Val Tyr Ala Ala Phe Ala 
            340                 345                 350         


Ser Leu Leu Asn Tyr Val Gly Ser Asp Asp Leu Gln Gly Lys Arg Val 
        355                 360                 365             


Gly Leu Phe Ser Tyr Gly Ser Gly Leu Ala Ala Ser Leu Tyr Ser Cys 
    370                 375                 380                 


Lys Ile Val Gly Asp Val Gln His Ile Ile Lys Glu Leu Asp Ile Thr 
385                 390                 395                 400 


Asn Lys Leu Ala Lys Arg Ile Thr Glu Thr Pro Lys Asp Tyr Glu Ala 
                405                 410                 415     


Ala Ile Glu Leu Arg Glu Asn Ala His Leu Lys Lys Asn Phe Lys Pro 
            420                 425                 430         


Gln Gly Ser Ile Glu His Leu Gln Ser Gly Val Tyr Tyr Leu Thr Asn 
        435                 440                 445             


Ile Asp Asp Lys Phe Arg Arg Ser Tyr Asp Val Lys Lys 
    450                 455                 460     


<210>  30
<211>  1197
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  30
atgtctcaga acgtttacat tgtatcgact gccagaaccc caattggttc attccagggt       60

tctctatcct ccaagacagc agtggaattg ggtgctgttg ctttaaaagg cgccttggct      120

aaggttccag aattggatgc atccaaggat tttgacgaaa ttatttttgg taacgttctt      180

tctgccaatt tgggccaagc tccggccaga caagttgctt tggctgccgg tttgagtaat      240

catatcgttg caagcacagt taacaaggtc tgtgcatccg ctatgaaggc aatcattttg      300

ggtgctcaat ccatcaaatg tggtaatgct gatgttgtcg tagctggtgg ttgtgaatct      360

atgactaacg caccatacta catgccagca gcccgtgcgg gtgccaaatt tggccaaact      420

gttcttgttg atggtgtcga aagagatggg ttgaacgatg cgtacgatgg tctagccatg      480

ggtgtacacg cagaaaagtg tgcccgtgat tgggatatta ctagagaaca acaagacaat      540

tttgccatcg aatcctacca aaaatctcaa aaatctcaaa aggaaggtaa attcgacaat      600

gaaattgtac ctgttaccat taagggattt agaggtaagc ctgatactca agtcacgaag      660

gacgaggaac ctgctagatt acacgttgaa aaattgagat ctgcaaggac tgttttccaa      720

aaagaaaacg gtactgttac tgccgctaac gcttctccaa tcaacgatgg tgctgcagcc      780

gtcatcttgg tttccgaaaa agttttgaag gaaaagaatt tgaagccttt ggctattatc      840

aaaggttggg gtgaggccgc tcatcaacca gctgatttta catgggctcc atctcttgca      900

gttccaaagg ctttgaaaca tgctggcatc gaagacatca attctgttga ttactttgaa      960

ttcaatgaag ccttttcggt tgtcggtttg gtgaacacta agattttgaa gctagaccca     1020

tctaaggtta atgtatatgg tggtgctgtt gctctaggtc acccattggg ttgttctggt     1080

gctagagtgg ttgttacact gctatccatc ttacagcaag aaggaggtaa gatcggtgtt     1140

gccgccattt gtaatggtgg tggtggtgct tcctctattg tcattgaaaa gatatga        1197


<210>  31
<211>  398
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  31

Met Ser Gln Asn Val Tyr Ile Val Ser Thr Ala Arg Thr Pro Ile Gly 
1               5                   10                  15      


Ser Phe Gln Gly Ser Leu Ser Ser Lys Thr Ala Val Glu Leu Gly Ala 
            20                  25                  30          


Val Ala Leu Lys Gly Ala Leu Ala Lys Val Pro Glu Leu Asp Ala Ser 
        35                  40                  45              


Lys Asp Phe Asp Glu Ile Ile Phe Gly Asn Val Leu Ser Ala Asn Leu 
    50                  55                  60                  


Gly Gln Ala Pro Ala Arg Gln Val Ala Leu Ala Ala Gly Leu Ser Asn 
65                  70                  75                  80  


His Ile Val Ala Ser Thr Val Asn Lys Val Cys Ala Ser Ala Met Lys 
                85                  90                  95      


Ala Ile Ile Leu Gly Ala Gln Ser Ile Lys Cys Gly Asn Ala Asp Val 
            100                 105                 110         


Val Val Ala Gly Gly Cys Glu Ser Met Thr Asn Ala Pro Tyr Tyr Met 
        115                 120                 125             


Pro Ala Ala Arg Ala Gly Ala Lys Phe Gly Gln Thr Val Leu Val Asp 
    130                 135                 140                 


Gly Val Glu Arg Asp Gly Leu Asn Asp Ala Tyr Asp Gly Leu Ala Met 
145                 150                 155                 160 


Gly Val His Ala Glu Lys Cys Ala Arg Asp Trp Asp Ile Thr Arg Glu 
                165                 170                 175     


Gln Gln Asp Asn Phe Ala Ile Glu Ser Tyr Gln Lys Ser Gln Lys Ser 
            180                 185                 190         


Gln Lys Glu Gly Lys Phe Asp Asn Glu Ile Val Pro Val Thr Ile Lys 
        195                 200                 205             


Gly Phe Arg Gly Lys Pro Asp Thr Gln Val Thr Lys Asp Glu Glu Pro 
    210                 215                 220                 


Ala Arg Leu His Val Glu Lys Leu Arg Ser Ala Arg Thr Val Phe Gln 
225                 230                 235                 240 


Lys Glu Asn Gly Thr Val Thr Ala Ala Asn Ala Ser Pro Ile Asn Asp 
                245                 250                 255     


Gly Ala Ala Ala Val Ile Leu Val Ser Glu Lys Val Leu Lys Glu Lys 
            260                 265                 270         


Asn Leu Lys Pro Leu Ala Ile Ile Lys Gly Trp Gly Glu Ala Ala His 
        275                 280                 285             


Gln Pro Ala Asp Phe Thr Trp Ala Pro Ser Leu Ala Val Pro Lys Ala 
    290                 295                 300                 


Leu Lys His Ala Gly Ile Glu Asp Ile Asn Ser Val Asp Tyr Phe Glu 
305                 310                 315                 320 


Phe Asn Glu Ala Phe Ser Val Val Gly Leu Val Asn Thr Lys Ile Leu 
                325                 330                 335     


Lys Leu Asp Pro Ser Lys Val Asn Val Tyr Gly Gly Ala Val Ala Leu 
            340                 345                 350         


Gly His Pro Leu Gly Cys Ser Gly Ala Arg Val Val Val Thr Leu Leu 
        355                 360                 365             


Ser Ile Leu Gln Gln Glu Gly Gly Lys Ile Gly Val Ala Ala Ile Cys 
    370                 375                 380                 


Asn Gly Gly Gly Gly Ala Ser Ser Ile Val Ile Glu Lys Ile 
385                 390                 395             


<210>  32
<211>  1191
<212>  DNA
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  32
atgaccgttt acacagcatc cgttaccgca cccgtcaaca tcgcaaccct taagtattgg       60

gggaaaaggg acacgaagtt gaatctgccc accaattcgt ccatatcagt gactttatcg      120

caagatgacc tcagaacgtt gacctctgcg gctactgcac ctgagtttga acgcgacact      180

ttgtggttaa atggagaacc acacagcatc gacaatgaaa gaactcaaaa ttgtctgcgc      240

gacctacgcc aattaagaaa ggaaatggaa tcgaaggacg cctcattgcc cacattatct      300

caatggaaac tccacattgt ctccgaaaat aactttccta cagcagctgg tttagcttcc      360

tccgctgctg gctttgctgc attggtctct gcaattgcta agttatacca attaccacag      420

tcaacttcag aaatatctag aatagcaaga aaggggtctg gttcagcttg tagatcgttg      480

tttggcggat acgtggcctg ggaaatggga aaagctgaag atggtcatga ttccatggca      540

gtacaaatcg cagacagctc tgactggcct cagatgaaag cttgtgtcct agttgtcagc      600

gatattaaaa aggatgtgag ttccactcag ggtatgcaat tgaccgtggc aacctccgaa      660

ctatttaaag aaagaattga acatgtcgta ccaaagagat ttgaagtcat gcgtaaagcc      720

attgttgaaa aagatttcgc cacctttgca aaggaaacaa tgatggattc caactctttc      780

catgccacat gtttggactc tttccctcca atattctaca tgaatgacac ttccaagcgt      840

atcatcagtt ggtgccacac cattaatcag ttttacggag aaacaatcgt tgcatacacg      900

tttgatgcag gtccaaatgc tgtgttgtac tacttagctg aaaatgagtc gaaactcttt      960

gcatttatct ataaattgtt tggctctgtt cctggatggg acaagaaatt tactactgag     1020

cagcttgagg ctttcaacca tcaatttgaa tcatctaact ttactgcacg tgaattggat     1080

cttgagttgc aaaaggatgt tgccagagtg attttaactc aagtcggttc aggcccacaa     1140

gaaacaaacg aatctttgat tgacgcaaag actggtctac caaaggaata a              1191


<210>  33
<211>  396
<212>  PRT
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  33

Met Thr Val Tyr Thr Ala Ser Val Thr Ala Pro Val Asn Ile Ala Thr 
1               5                   10                  15      


Leu Lys Tyr Trp Gly Lys Arg Asp Thr Lys Leu Asn Leu Pro Thr Asn 
            20                  25                  30          


Ser Ser Ile Ser Val Thr Leu Ser Gln Asp Asp Leu Arg Thr Leu Thr 
        35                  40                  45              


Ser Ala Ala Thr Ala Pro Glu Phe Glu Arg Asp Thr Leu Trp Leu Asn 
    50                  55                  60                  


Gly Glu Pro His Ser Ile Asp Asn Glu Arg Thr Gln Asn Cys Leu Arg 
65                  70                  75                  80  


Asp Leu Arg Gln Leu Arg Lys Glu Met Glu Ser Lys Asp Ala Ser Leu 
                85                  90                  95      


Pro Thr Leu Ser Gln Trp Lys Leu His Ile Val Ser Glu Asn Asn Phe 
            100                 105                 110         


Pro Thr Ala Ala Gly Leu Ala Ser Ser Ala Ala Gly Phe Ala Ala Leu 
        115                 120                 125             


Val Ser Ala Ile Ala Lys Leu Tyr Gln Leu Pro Gln Ser Thr Ser Glu 
    130                 135                 140                 


Ile Ser Arg Ile Ala Arg Lys Gly Ser Gly Ser Ala Cys Arg Ser Leu 
145                 150                 155                 160 


Phe Gly Gly Tyr Val Ala Trp Glu Met Gly Lys Ala Glu Asp Gly His 
                165                 170                 175     


Asp Ser Met Ala Val Gln Ile Ala Asp Ser Ser Asp Trp Pro Gln Met 
            180                 185                 190         


Lys Ala Cys Val Leu Val Val Ser Asp Ile Lys Lys Asp Val Ser Ser 
        195                 200                 205             


Thr Gln Gly Met Gln Leu Thr Val Ala Thr Ser Glu Leu Phe Lys Glu 
    210                 215                 220                 


Arg Ile Glu His Val Val Pro Lys Arg Phe Glu Val Met Arg Lys Ala 
225                 230                 235                 240 


Ile Val Glu Lys Asp Phe Ala Thr Phe Ala Lys Glu Thr Met Met Asp 
                245                 250                 255     


Ser Asn Ser Phe His Ala Thr Cys Leu Asp Ser Phe Pro Pro Ile Phe 
            260                 265                 270         


Tyr Met Asn Asp Thr Ser Lys Arg Ile Ile Ser Trp Cys His Thr Ile 
        275                 280                 285             


Asn Gln Phe Tyr Gly Glu Thr Ile Val Ala Tyr Thr Phe Asp Ala Gly 
    290                 295                 300                 


Pro Asn Ala Val Leu Tyr Tyr Leu Ala Glu Asn Glu Ser Lys Leu Phe 
305                 310                 315                 320 


Ala Phe Ile Tyr Lys Leu Phe Gly Ser Val Pro Gly Trp Asp Lys Lys 
                325                 330                 335     


Phe Thr Thr Glu Gln Leu Glu Ala Phe Asn His Gln Phe Glu Ser Ser 
            340                 345                 350         


Asn Phe Thr Ala Arg Glu Leu Asp Leu Glu Leu Gln Lys Asp Val Ala 
        355                 360                 365             


Arg Val Ile Leu Thr Gln Val Gly Ser Gly Pro Gln Glu Thr Asn Glu 
    370                 375                 380                 


Ser Leu Ile Asp Ala Lys Thr Gly Leu Pro Lys Glu 
385                 390                 395     


<210>  34
<211>  1707
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Pyruvate decarboxylase (Zm_PDC)  Codon optimized

<400>  34
atgtcctaca ccgttggtac ctacttagct gagcgtttgg tccaaatcgg tttgaagcac       60

catttcgccg ttgctggtga ttacaacttg gtcttgttag ataatttatt attgaacaag      120

aacatggaac aagtctactg ctgtaatgaa ttgaactgtg gtttctctgc tgaaggttat      180

gctagagcta aaggtgccgc tgccgctgtt gtcacttact ctgttggtgc tttgtctgcc      240

ttcgacgcta ttggtggtgc ttacgccgag aatttacctg ttattttaat ttctggtgcc      300

cctaacaata acgatcatgc tgctggtcat gttttacacc acgctttggg taaaactgac      360

taccattatc aattagagat ggccaaaaac atcaccgccg ctgccgaggc catttacact      420

ccagaagaag ccccagccaa aattgatcac gtcatcaaaa ccgccttgag agagaaaaaa      480

cctgtttact tggaaatcgc ctgtaatatc gcctctatgc cttgcgccgc tcctggtcct      540

gcttccgcct tattcaacga tgaggcttct gatgaagctt ccttaaacgc tgctgttgag      600

gagactttaa agttcatcgc taatagagat aaggtcgctg ttttagtcgg ttctaagttg      660

cgtgctgccg gtgccgagga agctgctgtt aaattcgccg atgctttagg tggtgctgtc      720

gccaccatgg ccgccgccaa atcctttttc cctgaagaaa acccacacta catcggtact      780

tcttggggtg aagtctctta cccaggtgtc gaaaagacta tgaaggaagc cgatgccgtc      840

atcgccttgg ccccagtttt taatgattat tccaccactg gttggactga tatcccagat      900

cctaaaaagt tagttttagc cgagcctaga tccgttgttg ttaacggtat tagattccct      960

tccgttcact tgaaggatta cttaactaga ttggctcaaa aggtttccaa gaagaccggt     1020

gctttggact ttttcaaatc tttgaacgcc ggtgagttaa agaaggccgc ccctgctgac     1080

ccatctgctc cattggttaa cgctgagatt gctagacaag tcgaagcttt attgacccca     1140

aacactaccg ttatcgccga aactggtgac tcttggttta atgctcaaag aatgaagtta     1200

ccaaatggtg ccagagttga gtacgaaatg caatggggtc atatcggttg gtctgtccca     1260

gctgcttttg gttatgctgt tggtgcccct gagagaagaa acatcttgat ggttggtgac     1320

ggttccttcc aattgactgc tcaagaagtc gctcaaatgg ttagattaaa attaccagtc     1380

atcatcttct tgatcaataa ctacggttac actatcgaag tcatgattca cgatggtcct     1440

tacaataata ttaagaactg ggactatgct ggtttgatgg aagtctttaa tggtaacggt     1500

ggttacgatt ccggtgctgg taagggttta aaggctaaga ctggtggtga attagctgaa     1560

gccattaagg ttgccttggc taacaccgac ggtcctactt taatcgaatg tttcattggt     1620

agagaggatt gtaccgaaga gttagttaag tggggtaaga gagttgccgc tgctaattcc     1680

cgtaagcctg tcaataaatt gttataa                                         1707


<210>  35
<211>  568
<212>  PRT
<213>  Zymomonas mobilis

<400>  35

Met Ser Tyr Thr Val Gly Thr Tyr Leu Ala Glu Arg Leu Val Gln Ile 
1               5                   10                  15      


Gly Leu Lys His His Phe Ala Val Ala Gly Asp Tyr Asn Leu Val Leu 
            20                  25                  30          


Leu Asp Asn Leu Leu Leu Asn Lys Asn Met Glu Gln Val Tyr Cys Cys 
        35                  40                  45              


Asn Glu Leu Asn Cys Gly Phe Ser Ala Glu Gly Tyr Ala Arg Ala Lys 
    50                  55                  60                  


Gly Ala Ala Ala Ala Val Val Thr Tyr Ser Val Gly Ala Leu Ser Ala 
65                  70                  75                  80  


Phe Asp Ala Ile Gly Gly Ala Tyr Ala Glu Asn Leu Pro Val Ile Leu 
                85                  90                  95      


Ile Ser Gly Ala Pro Asn Asn Asn Asp His Ala Ala Gly His Val Leu 
            100                 105                 110         


His His Ala Leu Gly Lys Thr Asp Tyr His Tyr Gln Leu Glu Met Ala 
        115                 120                 125             


Lys Asn Ile Thr Ala Ala Ala Glu Ala Ile Tyr Thr Pro Glu Glu Ala 
    130                 135                 140                 


Pro Ala Lys Ile Asp His Val Ile Lys Thr Ala Leu Arg Glu Lys Lys 
145                 150                 155                 160 


Pro Val Tyr Leu Glu Ile Ala Cys Asn Ile Ala Ser Met Pro Cys Ala 
                165                 170                 175     


Ala Pro Gly Pro Ala Ser Ala Leu Phe Asn Asp Glu Ala Ser Asp Glu 
            180                 185                 190         


Ala Ser Leu Asn Ala Ala Val Glu Glu Thr Leu Lys Phe Ile Ala Asn 
        195                 200                 205             


Arg Asp Lys Val Ala Val Leu Val Gly Ser Lys Leu Arg Ala Ala Gly 
    210                 215                 220                 


Ala Glu Glu Ala Ala Val Lys Phe Ala Asp Ala Leu Gly Gly Ala Val 
225                 230                 235                 240 


Ala Thr Met Ala Ala Ala Lys Ser Phe Phe Pro Glu Glu Asn Pro His 
                245                 250                 255     


Tyr Ile Gly Thr Ser Trp Gly Glu Val Ser Tyr Pro Gly Val Glu Lys 
            260                 265                 270         


Thr Met Lys Glu Ala Asp Ala Val Ile Ala Leu Ala Pro Val Phe Asn 
        275                 280                 285             


Asp Tyr Ser Thr Thr Gly Trp Thr Asp Ile Pro Asp Pro Lys Lys Leu 
    290                 295                 300                 


Val Leu Ala Glu Pro Arg Ser Val Val Val Asn Gly Ile Arg Phe Pro 
305                 310                 315                 320 


Ser Val His Leu Lys Asp Tyr Leu Thr Arg Leu Ala Gln Lys Val Ser 
                325                 330                 335     


Lys Lys Thr Gly Ala Leu Asp Phe Phe Lys Ser Leu Asn Ala Gly Glu 
            340                 345                 350         


Leu Lys Lys Ala Ala Pro Ala Asp Pro Ser Ala Pro Leu Val Asn Ala 
        355                 360                 365             


Glu Ile Ala Arg Gln Val Glu Ala Leu Leu Thr Pro Asn Thr Thr Val 
    370                 375                 380                 


Ile Ala Glu Thr Gly Asp Ser Trp Phe Asn Ala Gln Arg Met Lys Leu 
385                 390                 395                 400 


Pro Asn Gly Ala Arg Val Glu Tyr Glu Met Gln Trp Gly His Ile Gly 
                405                 410                 415     


Trp Ser Val Pro Ala Ala Phe Gly Tyr Ala Val Gly Ala Pro Glu Arg 
            420                 425                 430         


Arg Asn Ile Leu Met Val Gly Asp Gly Ser Phe Gln Leu Thr Ala Gln 
        435                 440                 445             


Glu Val Ala Gln Met Val Arg Leu Lys Leu Pro Val Ile Ile Phe Leu 
    450                 455                 460                 


Ile Asn Asn Tyr Gly Tyr Thr Ile Glu Val Met Ile His Asp Gly Pro 
465                 470                 475                 480 


Tyr Asn Asn Ile Lys Asn Trp Asp Tyr Ala Gly Leu Met Glu Val Phe 
                485                 490                 495     


Asn Gly Asn Gly Gly Tyr Asp Ser Gly Ala Gly Lys Gly Leu Lys Ala 
            500                 505                 510         


Lys Thr Gly Gly Glu Leu Ala Glu Ala Ile Lys Val Ala Leu Ala Asn 
        515                 520                 525             


Thr Asp Gly Pro Thr Leu Ile Glu Cys Phe Ile Gly Arg Glu Asp Cys 
    530                 535                 540                 


Thr Glu Glu Leu Val Lys Trp Gly Lys Arg Val Ala Ala Ala Asn Ser 
545                 550                 555                 560 


Arg Lys Pro Val Asn Lys Leu Leu 
                565             


<210>  36
<211>  1356
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  36
atgtcagagt tgagagcctt cagtgcccca gggaaagcgt tactagctgg tggatattta       60

gttttagatc cgaaatatga agcatttgta gtcggattat cggcaagaat gcatgctgta      120

gcccatcctt acggttcatt gcaagagtct gataagtttg aagtgcgtgt gaaaagtaaa      180

caatttaaag atggggagtg gctgtaccat ataagtccta aaactggctt cattcctgtt      240

tcgataggcg gatctaagaa ccctttcatt gaaaaagtta tcgctaacgt atttagctac      300

tttaagccta acatggacga ctactgcaat agaaacttgt tcgttattga tattttctct      360

gatgatgcct accattctca ggaggacagc gttaccgaac atcgtggcaa cagaagattg      420

agttttcatt cgcacagaat tgaagaagtt cccaaaacag ggctgggctc ctcggcaggt      480

ttagtcacag ttttaactac agctttggcc tccttttttg tatcggacct ggaaaataat      540

gtagacaaat atagagaagt tattcataat ttatcacaag ttgctcattg tcaagctcag      600

ggtaaaattg gaagcgggtt tgatgtagcg gcggcagcat atggatctat cagatataga      660

agattcccac ccgcattaat ctctaatttg ccagatattg gaagtgctac ttacggcagt      720

aaactggcgc atttggttaa tgaagaagac tggaatataa cgattaaaag taaccattta      780

ccttcgggat taactttatg gatgggcgat attaagaatg gttcagaaac agtaaaactg      840

gtccagaagg taaaaaattg gtatgattcg catatgccgg aaagcttgaa aatatataca      900

gaactcgatc atgcaaattc tagatttatg gatggactat ctaaactaga tcgcttacac      960

gagactcatg acgattacag cgatcagata tttgagtctc ttgagaggaa tgactgtacc     1020

tgtcaaaagt atcctgagat cacagaagtt agagatgcag ttgccacaat tagacgttcc     1080

tttagaaaaa taactaaaga atctggtgcc gatatcgaac ctcccgtaca aactagctta     1140

ttggatgatt gccagacctt aaaaggagtt cttacttgct taatacctgg tgctggtggt     1200

tatgacgcca ttgcagtgat tgctaagcaa gatgttgatc ttagggctca aaccgctgat     1260

gacaaaagat tttctaaggt tcaatggctg gatgtaactc aggctgactg gggtgttagg     1320

aaagaaaaag atccggaaac ttatcttgat aaataa                               1356


<210>  37
<211>  451
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  37

Met Ser Glu Leu Arg Ala Phe Ser Ala Pro Gly Lys Ala Leu Leu Ala 
1               5                   10                  15      


Gly Gly Tyr Leu Val Leu Asp Pro Lys Tyr Glu Ala Phe Val Val Gly 
            20                  25                  30          


Leu Ser Ala Arg Met His Ala Val Ala His Pro Tyr Gly Ser Leu Gln 
        35                  40                  45              


Glu Ser Asp Lys Phe Glu Val Arg Val Lys Ser Lys Gln Phe Lys Asp 
    50                  55                  60                  


Gly Glu Trp Leu Tyr His Ile Ser Pro Lys Thr Gly Phe Ile Pro Val 
65                  70                  75                  80  


Ser Ile Gly Gly Ser Lys Asn Pro Phe Ile Glu Lys Val Ile Ala Asn 
                85                  90                  95      


Val Phe Ser Tyr Phe Lys Pro Asn Met Asp Asp Tyr Cys Asn Arg Asn 
            100                 105                 110         


Leu Phe Val Ile Asp Ile Phe Ser Asp Asp Ala Tyr His Ser Gln Glu 
        115                 120                 125             


Asp Ser Val Thr Glu His Arg Gly Asn Arg Arg Leu Ser Phe His Ser 
    130                 135                 140                 


His Arg Ile Glu Glu Val Pro Lys Thr Gly Leu Gly Ser Ser Ala Gly 
145                 150                 155                 160 


Leu Val Thr Val Leu Thr Thr Ala Leu Ala Ser Phe Phe Val Ser Asp 
                165                 170                 175     


Leu Glu Asn Asn Val Asp Lys Tyr Arg Glu Val Ile His Asn Leu Ser 
            180                 185                 190         


Gln Val Ala His Cys Gln Ala Gln Gly Lys Ile Gly Ser Gly Phe Asp 
        195                 200                 205             


Val Ala Ala Ala Ala Tyr Gly Ser Ile Arg Tyr Arg Arg Phe Pro Pro 
    210                 215                 220                 


Ala Leu Ile Ser Asn Leu Pro Asp Ile Gly Ser Ala Thr Tyr Gly Ser 
225                 230                 235                 240 


Lys Leu Ala His Leu Val Asn Glu Glu Asp Trp Asn Ile Thr Ile Lys 
                245                 250                 255     


Ser Asn His Leu Pro Ser Gly Leu Thr Leu Trp Met Gly Asp Ile Lys 
            260                 265                 270         


Asn Gly Ser Glu Thr Val Lys Leu Val Gln Lys Val Lys Asn Trp Tyr 
        275                 280                 285             


Asp Ser His Met Pro Glu Ser Leu Lys Ile Tyr Thr Glu Leu Asp His 
    290                 295                 300                 


Ala Asn Ser Arg Phe Met Asp Gly Leu Ser Lys Leu Asp Arg Leu His 
305                 310                 315                 320 


Glu Thr His Asp Asp Tyr Ser Asp Gln Ile Phe Glu Ser Leu Glu Arg 
                325                 330                 335     


Asn Asp Cys Thr Cys Gln Lys Tyr Pro Glu Ile Thr Glu Val Arg Asp 
            340                 345                 350         


Ala Val Ala Thr Ile Arg Arg Ser Phe Arg Lys Ile Thr Lys Glu Ser 
        355                 360                 365             


Gly Ala Asp Ile Glu Pro Pro Val Gln Thr Ser Leu Leu Asp Asp Cys 
    370                 375                 380                 


Gln Thr Leu Lys Gly Val Leu Thr Cys Leu Ile Pro Gly Ala Gly Gly 
385                 390                 395                 400 


Tyr Asp Ala Ile Ala Val Ile Ala Lys Gln Asp Val Asp Leu Arg Ala 
                405                 410                 415     


Gln Thr Ala Asp Asp Lys Arg Phe Ser Lys Val Gln Trp Leu Asp Val 
            420                 425                 430         


Thr Gln Ala Asp Trp Gly Val Arg Lys Glu Lys Asp Pro Glu Thr Tyr 
        435                 440                 445             


Leu Asp Lys 
    450     


<210>  38
<211>  1332
<212>  DNA
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  38
atgtcattac cgttcttaac ttctgcaccg ggaaaggtta ttatttttgg tgaacactct       60

gctgtgtaca acaagcctgc cgtcgctgct agtgtgtctg cgttgagaac ctacctgcta      120

ataagcgagt catctgcacc agatactatt gaattggact tcccggacat tagctttaat      180

cataagtggt ccatcaatga tttcaatgcc atcaccgagg atcaagtaaa ctcccaaaaa      240

ttggccaagg ctcaacaagc caccgatggc ttgtctcagg aactcgttag tcttttggat      300

ccgttgttag ctcaactatc cgaatccttc cactaccatg cagcgttttg tttcctgtat      360

atgtttgttt gcctatgccc ccatgccaag aatattaagt tttctttaaa gtctacttta      420

cccatcggtg ctgggttggg ctcaagcgcc tctatttctg tatcactggc cttagctatg      480

gcctacttgg gggggttaat aggatctaat gacttggaaa agctgtcaga aaacgataag      540

catatagtga atcaatgggc cttcataggt gaaaagtgta ttcacggtac cccttcagga      600

atagataacg ctgtggccac ttatggtaat gccctgctat ttgaaaaaga ctcacataat      660

ggaacaataa acacaaacaa ttttaagttc ttagatgatt tcccagccat tccaatgatc      720

ctaacctata ctagaattcc aaggtctaca aaagatcttg ttgctcgcgt tcgtgtgttg      780

gtcaccgaga aatttcctga agttatgaag ccaattctag atgccatggg tgaatgtgcc      840

ctacaaggct tagagatcat gactaagtta agtaaatgta aaggcaccga tgacgaggct      900

gtagaaacta ataatgaact gtatgaacaa ctattggaat tgataagaat aaatcatgga      960

ctgcttgtct caatcggtgt ttctcatcct ggattagaac ttattaaaaa tctgagcgat     1020

gatttgagaa ttggctccac aaaacttacc ggtgctggtg gcggcggttg ctctttgact     1080

ttgttacgaa gagacattac tcaagagcaa attgacagtt tcaaaaagaa attgcaagat     1140

gattttagtt acgagacatt tgaaacagac ttgggtggga ctggctgctg tttgttaagc     1200

gcaaaaaatt tgaataaaga tcttaaaatc aaatccctag tattccaatt atttgaaaat     1260

aaaactacca caaagcaaca aattgacgat ctattattgc caggaaacac gaatttacca     1320

tggacttcat aa                                                         1332


<210>  39
<211>  443
<212>  PRT
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  39

Met Ser Leu Pro Phe Leu Thr Ser Ala Pro Gly Lys Val Ile Ile Phe 
1               5                   10                  15      


Gly Glu His Ser Ala Val Tyr Asn Lys Pro Ala Val Ala Ala Ser Val 
            20                  25                  30          


Ser Ala Leu Arg Thr Tyr Leu Leu Ile Ser Glu Ser Ser Ala Pro Asp 
        35                  40                  45              


Thr Ile Glu Leu Asp Phe Pro Asp Ile Ser Phe Asn His Lys Trp Ser 
    50                  55                  60                  


Ile Asn Asp Phe Asn Ala Ile Thr Glu Asp Gln Val Asn Ser Gln Lys 
65                  70                  75                  80  


Leu Ala Lys Ala Gln Gln Ala Thr Asp Gly Leu Ser Gln Glu Leu Val 
                85                  90                  95      


Ser Leu Leu Asp Pro Leu Leu Ala Gln Leu Ser Glu Ser Phe His Tyr 
            100                 105                 110         


His Ala Ala Phe Cys Phe Leu Tyr Met Phe Val Cys Leu Cys Pro His 
        115                 120                 125             


Ala Lys Asn Ile Lys Phe Ser Leu Lys Ser Thr Leu Pro Ile Gly Ala 
    130                 135                 140                 


Gly Leu Gly Ser Ser Ala Ser Ile Ser Val Ser Leu Ala Leu Ala Met 
145                 150                 155                 160 


Ala Tyr Leu Gly Gly Leu Ile Gly Ser Asn Asp Leu Glu Lys Leu Ser 
                165                 170                 175     


Glu Asn Asp Lys His Ile Val Asn Gln Trp Ala Phe Ile Gly Glu Lys 
            180                 185                 190         


Cys Ile His Gly Thr Pro Ser Gly Ile Asp Asn Ala Val Ala Thr Tyr 
        195                 200                 205             


Gly Asn Ala Leu Leu Phe Glu Lys Asp Ser His Asn Gly Thr Ile Asn 
    210                 215                 220                 


Thr Asn Asn Phe Lys Phe Leu Asp Asp Phe Pro Ala Ile Pro Met Ile 
225                 230                 235                 240 


Leu Thr Tyr Thr Arg Ile Pro Arg Ser Thr Lys Asp Leu Val Ala Arg 
                245                 250                 255     


Val Arg Val Leu Val Thr Glu Lys Phe Pro Glu Val Met Lys Pro Ile 
            260                 265                 270         


Leu Asp Ala Met Gly Glu Cys Ala Leu Gln Gly Leu Glu Ile Met Thr 
        275                 280                 285             


Lys Leu Ser Lys Cys Lys Gly Thr Asp Asp Glu Ala Val Glu Thr Asn 
    290                 295                 300                 


Asn Glu Leu Tyr Glu Gln Leu Leu Glu Leu Ile Arg Ile Asn His Gly 
305                 310                 315                 320 


Leu Leu Val Ser Ile Gly Val Ser His Pro Gly Leu Glu Leu Ile Lys 
                325                 330                 335     


Asn Leu Ser Asp Asp Leu Arg Ile Gly Ser Thr Lys Leu Thr Gly Ala 
            340                 345                 350         


Gly Gly Gly Gly Cys Ser Leu Thr Leu Leu Arg Arg Asp Ile Thr Gln 
        355                 360                 365             


Glu Gln Ile Asp Ser Phe Lys Lys Lys Leu Gln Asp Asp Phe Ser Tyr 
    370                 375                 380                 


Glu Thr Phe Glu Thr Asp Leu Gly Gly Thr Gly Cys Cys Leu Leu Ser 
385                 390                 395                 400 


Ala Lys Asn Leu Asn Lys Asp Leu Lys Ile Lys Ser Leu Val Phe Gln 
                405                 410                 415     


Leu Phe Glu Asn Lys Thr Thr Thr Lys Gln Gln Ile Asp Asp Leu Leu 
            420                 425                 430         


Leu Pro Gly Asn Thr Asn Leu Pro Trp Thr Ser 
        435                 440             


<210>  40
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Variant farnesyl pyrophosphate synthase (ERG20mut, F96W, N127W; GPPS) Codon optimized

<400>  40
atggcttctg agaaggagat tcgtcgtgag agattcttga atgtttttcc taaattagtc       60

gaggaattga acgcttcttt gttggcttat ggtatgccta aggaagcttg tgattggtat      120

gctcactcct tgaattataa tactccaggt ggtaaattga accgtggttt gtctgttgtt      180

gacacttacg ctattttatc taacaagacc gtcgagcaat tgggtcaaga agagtatgaa      240

aaggtcgcta ttttaggttg gtgtattgaa ttgttgcaag cttactggtt ggttgccgat      300

gacatgatgg acaagtctat tactcgtcgt ggtcaacctt gctggtataa ggtcccagag      360

gttggtgaaa ttgctatctg ggacgctttc atgttggaag ctgctatcta taaattgttg      420

aaatcccact tcagaaacga gaaatactac attgacatca ccgagttgtt ccacgaagtc      480

actttccaaa ctgagttagg tcaattaatg gacttgatca ccgctccaga agacaaagtt      540

gacttgtcca agttttcctt gaaaaagcac tctttcatcg ttactttcaa gactgcttat      600

tactctttct acttaccagt tgccttggct atgtacgtcg ccggtatcac tgacgaaaag      660

gacttgaagc aagctcgtga cgttttgatt ccattaggtg aatatttcca aatccaagat      720

gactacttag actgttttgg tacccctgaa caaatcggta agatcggtac tgatattcaa      780

gataacaagt gctcttgggt tatcaacaag gctttagagt tagcctccgc cgaacaacgt      840

aaaactttag atgaaaacta cggtaaaaaa gactctgttg ctgaggccaa gtgtaagaag      900

atttttaacg atttaaaaat cgaacaattg tatcacgaat atgaagagtc cattgctaag      960

gatttgaagg ctaaaatttc tcaagttgac gaatcccgtg gtttcaaagc tgacgttttg     1020

actgcttttt taaacaaggt ttacaagcgt tccaaataa                            1059


<210>  41
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Variant farnesyl pyrophosphate synthase (ERG20mut, F96W, N127W; GPPS)

<400>  41

Met Ala Ser Glu Lys Glu Ile Arg Arg Glu Arg Phe Leu Asn Val Phe 
1               5                   10                  15      


Pro Lys Leu Val Glu Glu Leu Asn Ala Ser Leu Leu Ala Tyr Gly Met 
            20                  25                  30          


Pro Lys Glu Ala Cys Asp Trp Tyr Ala His Ser Leu Asn Tyr Asn Thr 
        35                  40                  45              


Pro Gly Gly Lys Leu Asn Arg Gly Leu Ser Val Val Asp Thr Tyr Ala 
    50                  55                  60                  


Ile Leu Ser Asn Lys Thr Val Glu Gln Leu Gly Gln Glu Glu Tyr Glu 
65                  70                  75                  80  


Lys Val Ala Ile Leu Gly Trp Cys Ile Glu Leu Leu Gln Ala Tyr Trp 
                85                  90                  95      


Leu Val Ala Asp Asp Met Met Asp Lys Ser Ile Thr Arg Arg Gly Gln 
            100                 105                 110         


Pro Cys Trp Tyr Lys Val Pro Glu Val Gly Glu Ile Ala Ile Trp Asp 
        115                 120                 125             


Ala Phe Met Leu Glu Ala Ala Ile Tyr Lys Leu Leu Lys Ser His Phe 
    130                 135                 140                 


Arg Asn Glu Lys Tyr Tyr Ile Asp Ile Thr Glu Leu Phe His Glu Val 
145                 150                 155                 160 


Thr Phe Gln Thr Glu Leu Gly Gln Leu Met Asp Leu Ile Thr Ala Pro 
                165                 170                 175     


Glu Asp Lys Val Asp Leu Ser Lys Phe Ser Leu Lys Lys His Ser Phe 
            180                 185                 190         


Ile Val Thr Phe Lys Thr Ala Tyr Tyr Ser Phe Tyr Leu Pro Val Ala 
        195                 200                 205             


Leu Ala Met Tyr Val Ala Gly Ile Thr Asp Glu Lys Asp Leu Lys Gln 
    210                 215                 220                 


Ala Arg Asp Val Leu Ile Pro Leu Gly Glu Tyr Phe Gln Ile Gln Asp 
225                 230                 235                 240 


Asp Tyr Leu Asp Cys Phe Gly Thr Pro Glu Gln Ile Gly Lys Ile Gly 
                245                 250                 255     


Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Val Ile Asn Lys Ala Leu 
            260                 265                 270         


Glu Leu Ala Ser Ala Glu Gln Arg Lys Thr Leu Asp Glu Asn Tyr Gly 
        275                 280                 285             


Lys Lys Asp Ser Val Ala Glu Ala Lys Cys Lys Lys Ile Phe Asn Asp 
    290                 295                 300                 


Leu Lys Ile Glu Gln Leu Tyr His Glu Tyr Glu Glu Ser Ile Ala Lys 
305                 310                 315                 320 


Asp Leu Lys Ala Lys Ile Ser Gln Val Asp Glu Ser Arg Gly Phe Lys 
                325                 330                 335     


Ala Asp Val Leu Thr Ala Phe Leu Asn Lys Val Tyr Lys Arg Ser Lys 
            340                 345                 350         


<210>  42
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  GFP

<400>  42
atgtctaccg cactaacaga aggagctaaa ctattcgaaa aggagattcc ttacattaca       60

gaattagagg gtgatgtcga aggaatgaaa ttcattatca agggcgaggg tactggtgac      120

gctactaccg gtacgattaa agcaaagtac atctgtacaa caggtgacct tcctgttccg      180

tgggctactc tggtgagcac tttgtcttat ggagttcaat gttttgctaa atacccttcg      240

cacattaaag actttttcaa aagtgcaatg cctgagggct atactcagga gagaacaata      300

tctttcgaag gagatggtgt gtataagact agggctatgg tcacgtatga aagaggatcc      360

atctacaata gagtaacttt aactggtgaa aacttcaaaa aggacggtca catccttaga      420

aagaatgttg cctttcaatg cccaccatcc atcttgtaca ttttgccaga cacagttaac      480

aatggtatca gagttgagtt taaccaagct tatgacatag agggtgtcac cgaaaagttg      540

gttacaaaat gttcacagat gaatcgtccc ctggcaggat cagctgccgt ccatatccca      600

cgttaccatc atatcactta tcataccaag ctgtccaaag atcgtgatga gagaagggat      660

cacatgtgtt tggttgaagt ggtaaaggcc gtggatttgg atacttacca aggttga         717


<210>  43
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GFP

<400>  43

Met Ser Thr Ala Leu Thr Glu Gly Ala Lys Leu Phe Glu Lys Glu Ile 
1               5                   10                  15      


Pro Tyr Ile Thr Glu Leu Glu Gly Asp Val Glu Gly Met Lys Phe Ile 
            20                  25                  30          


Ile Lys Gly Glu Gly Thr Gly Asp Ala Thr Thr Gly Thr Ile Lys Ala 
        35                  40                  45              


Lys Tyr Ile Cys Thr Thr Gly Asp Leu Pro Val Pro Trp Ala Thr Leu 
    50                  55                  60                  


Val Ser Thr Leu Ser Tyr Gly Val Gln Cys Phe Ala Lys Tyr Pro Ser 
65                  70                  75                  80  


His Ile Lys Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Thr Gln 
                85                  90                  95      


Glu Arg Thr Ile Ser Phe Glu Gly Asp Gly Val Tyr Lys Thr Arg Ala 
            100                 105                 110         


Met Val Thr Tyr Glu Arg Gly Ser Ile Tyr Asn Arg Val Thr Leu Thr 
        115                 120                 125             


Gly Glu Asn Phe Lys Lys Asp Gly His Ile Leu Arg Lys Asn Val Ala 
    130                 135                 140                 


Phe Gln Cys Pro Pro Ser Ile Leu Tyr Ile Leu Pro Asp Thr Val Asn 
145                 150                 155                 160 


Asn Gly Ile Arg Val Glu Phe Asn Gln Ala Tyr Asp Ile Glu Gly Val 
                165                 170                 175     


Thr Glu Lys Leu Val Thr Lys Cys Ser Gln Met Asn Arg Pro Leu Ala 
            180                 185                 190         


Gly Ser Ala Ala Val His Ile Pro Arg Tyr His His Ile Thr Tyr His 
        195                 200                 205             


Thr Lys Leu Ser Lys Asp Arg Asp Glu Arg Arg Asp His Met Cys Leu 
    210                 215                 220                 


Val Glu Val Val Lys Ala Val Asp Leu Asp Thr Tyr Gln Gly 
225                 230                 235             


<210>  44
<211>  545
<212>  PRT
<213>  Cannabis sativa

<400>  44

Met Asn Cys Ser Ala Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Leu Ser Phe His Ile Gln Ile Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Lys His Ile Pro Asn Asn Val Ala Asn 
        35                  40                  45              


Pro Lys Leu Val Tyr Thr Gln His Asp Gln Leu Tyr Met Ser Ile Leu 
    50                  55                  60                  


Asn Ser Thr Ile Gln Asn Leu Arg Phe Ile Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser Asn Asn Ser His Ile Gln Ala Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Val Val Asp Leu Arg Asn Met His Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Ile Asn Glu Lys Asn Glu Asn Leu Ser Phe Pro Gly Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Gly Val Gly Gly His Phe Ser Gly Gly Gly Tyr Gly Ala 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val Asp Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Ile Arg Gly Gly Gly Gly Glu Asn Phe Gly Ile 
225                 230                 235                 240 


Ile Ala Ala Trp Lys Ile Lys Leu Val Ala Val Pro Ser Lys Ser Thr 
                245                 250                 255     


Ile Phe Ser Val Lys Lys Asn Met Glu Ile His Gly Leu Val Lys Leu 
            260                 265                 270         


Phe Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Val 
        275                 280                 285             


Leu Met Thr His Phe Ile Thr Lys Asn Ile Thr Asp Asn His Gly Lys 
    290                 295                 300                 


Asn Lys Thr Thr Val His Gly Tyr Phe Ser Ser Ile Phe His Gly Gly 
305                 310                 315                 320 


Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly 
                325                 330                 335     


Ile Lys Lys Thr Asp Cys Lys Glu Phe Ser Trp Ile Asp Thr Thr Ile 
            340                 345                 350         


Phe Tyr Ser Gly Val Val Asn Phe Asn Thr Ala Asn Phe Lys Lys Glu 
        355                 360                 365             


Ile Leu Leu Asp Arg Ser Ala Gly Lys Lys Thr Ala Phe Ser Ile Lys 
    370                 375                 380                 


Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Thr Ala Met Val Lys Ile 
385                 390                 395                 400 


Leu Glu Lys Leu Tyr Glu Glu Asp Val Gly Ala Gly Met Tyr Val Leu 
                405                 410                 415     


Tyr Pro Tyr Gly Gly Ile Met Glu Glu Ile Ser Glu Ser Ala Ile Pro 
            420                 425                 430         


Phe Pro His Arg Ala Gly Ile Met Tyr Glu Leu Trp Tyr Thr Ala Ser 
        435                 440                 445             


Trp Glu Lys Gln Glu Asp Asn Glu Lys His Ile Asn Trp Val Arg Ser 
    450                 455                 460                 


Val Tyr Asn Phe Thr Thr Pro Tyr Val Ser Gln Asn Pro Arg Leu Ala 
465                 470                 475                 480 


Tyr Leu Asn Tyr Arg Asp Leu Asp Leu Gly Lys Thr Asn His Ala Ser 
                485                 490                 495     


Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly 
            500                 505                 510         


Lys Asn Phe Asn Arg Leu Val Lys Val Lys Thr Lys Val Asp Pro Asn 
        515                 520                 525             


Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Pro His His 
    530                 535                 540                 


His 
545 


<210>  45
<211>  1638
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  THCA synthase Codon optimized sequence 1

<400>  45
atgaattgtt ctgctttctc tttctggttc gtttgtaaga tcatcttttt cttcttatct       60

ttccatattc aaatctctat cgctaaccct cgtgagaact tcttgaaatg tttctccaaa      120

catatcccaa acaatgtcgc taaccctaag ttagtttaca ctcaacatga tcaattatat      180

atgtctatct tgaactctac catccaaaac ttgagattca tctccgatac caccccaaaa      240

ccattggtta ttgttacccc atccaacaat tctcatattc aagctaccat tttgtgctcc      300

aaaaaggtcg gtttgcaaat ccgtactaga tctggtggtc acgatgctga aggtatgtct      360

tacatttccc aagtcccatt cgttgttgtc gatttaagaa atatgcactc tatcaaaatc      420

gacgttcact ctcaaactgc ttgggttgaa gccggtgcca ctttaggtga ggtttactac      480

tggattaacg aaaagaatga aaacttatcc tttccaggtg gttactgtcc aactgttggt      540

gttggtggtc acttctctgg tggtggttat ggtgccttga tgagaaacta cggtttagct      600

gctgataata ttatcgacgc tcacttggtt aatgtcgacg gtaaggtttt ggacagaaaa      660

tccatgggtg aagatttatt ctgggccatt agaggtggtg gtggtgaaaa cttcggtatc      720

attgctgctt ggaaaattaa attggtcgct gtcccatcca agtctactat tttctccgtc      780

aagaaaaaca tggaaattca tggtttggtt aaattattca acaagtggca aaacattgct      840

tacaaatacg acaaagactt agttttgatg acccacttca ttactaaaaa cattaccgac      900

aaccatggta aaaataaaac tactgttcac ggttacttct cttccatttt tcatggtggt      960

gtcgactcct tggtcgattt aatgaacaaa tctttccctg agttgggtat caagaagacc     1020

gactgtaaag aattctcttg gatcgacact actattttct actctggtgt cgttaacttc     1080

aacaccgcta atttcaagaa ggaaatttta ttagatagat ccgctggtaa aaagaccgct     1140

ttctctatca aattagacta cgttaaaaaa ccaatcccag aaaccgctat ggtcaaaatc     1200

ttggaaaaat tatatgaaga agacgttggt gccggtatgt acgtcttata tccatatggt     1260

ggtattatgg aagagatctc tgaatccgct atcccttttc cacacagagc cggtattatg     1320

tacgaattat ggtacactgc ttcctgggag aaacaagaag ataatgaaaa gcacattaac     1380

tgggttagat ctgtttacaa cttcactact ccatacgtct ctcaaaaccc aagattagcc     1440

tacttaaact accgtgattt ggatttaggt aaaactaatc acgcttcccc aaacaactac     1500

acccaagcta gaatttgggg tgagaagtac tttggtaaga acttcaaccg tttagtcaag     1560

gtcaagacta aagttgatcc aaacaatttt ttcagaaacg aacaatctat cccaccttta     1620

ccaccacacc accattag                                                   1638


<210>  46
<211>  878
<212>  DNA
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  46
tgttgtggaa atgtaaagag ccccattatc ttagcctaaa aaaaccttct ctttggaact       60

ttcagtaata cgcttaactg ctcattgcta tattgaagta cggattagaa gccgccgagc      120

gggcgacagc cctccgacgg aagactctcc tccgtgcgtc ctggtcttca ccggtcgcgt      180

tcctgaaacg cagatgtgcc tcgcgccgca ctgctccgaa caataaagat tctacaatac      240

tagcttttat ggttatgaag aggaaaaatt ggcagtaacc tggccccaca aaccttcaaa      300

tcaacgaatc aaattaacaa ccataggata ataatgcgat tagtttttta gccttatttc      360

tggggtaatt aatcagcgaa gcgatgattt ttgatctatt aacagatata taaatgcaaa      420

agctgcataa ccactttaac taatactttc aacattttcg gtttgtatta cttcttattc      480

aaatgtcata aaagtatcaa caaaaaattg ttaatatacc tctatacttt aacgtcaagg      540

agaaaaaact atactcttat taccctatcc tatggataaa gcaatcttga tgaggataat      600

gatttttttt tgaatataca taaatactac cgtttttctg ctagattttg tgaagacgta      660

aataagtaca tattactttt taagccaaga caagattaag cattaacttt acccttttct      720

cttctaagtt tcaatactag ttatcactgt ttaaaagtta tggcgagaac gtcggcggtt      780

aaaatatatt accctgaacg tggtgaattg aagttctagg atggtttaaa gatttttcct      840

ttttgggaaa taagtaaaca atatattgct gcctttgc                              878


<210>  47
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  OAC Y27F variant (OAC) Codon optimized

<400>  47
atggccgtca aacacttgat cgtcttaaaa ttcaaggatg aaattactga agctcaaaaa       60

gaagagttct tcaaaacctt cgtcaattta gtcaacatta ttcctgctat gaaggacgtt      120

tactggggta aggatgtcac ccaaaagaac aaggaagaag gttacactca cattgttgaa      180

gtcactttcg aatctgttga aactatccaa gattatatta tccacccagc tcatgtcggt      240

tttggtgatg tttacagatc tttttgggaa aaattgttga tctttgacta tactccaaga      300

aaataa                                                                 306


<210>  48
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OAC Y27F variant (OAC)

<400>  48

Met Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr 
1               5                   10                  15      


Glu Ala Gln Lys Glu Glu Phe Phe Lys Thr Phe Val Asn Leu Val Asn 
            20                  25                  30          


Ile Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr Gln 
        35                  40                  45              


Lys Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu 
    50                  55                  60                  


Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly 
65                  70                  75                  80  


Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp 
                85                  90                  95      


Tyr Thr Pro Arg Lys 
            100     


<210>  49
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, C12F variant Codon optimized

<400>  49
atgaaatgct ccactttctc tttctggttc gtttttaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  50
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, C12F variant

<400>  50

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Phe Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  51
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, F17M variant Codon optimized

<400>  51
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttcat gttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  52
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, F17M variant

<400>  52

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Met Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  53
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, F18T variant Codon optimized

<400>  53
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cactttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  54
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, F18T variant

<400>  54

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Thr Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  55
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, F18W variant Codon optimized

<400>  55
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt ctggttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  56
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, F18W variant

<400>  56

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Trp Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  57
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S20G variant Codon optimized

<400>  57
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttctttggt       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  58
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S20G variant

<400>  58

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Gly Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  59
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, R31Q variant Codon optimized

<400>  59
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct caagagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  60
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, R31Q variant

<400>  60

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Gln Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  61
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N33K variant Codon optimized

<400>  61
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaaat tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  62
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N33K variant

<400>  62

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Lys Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  63
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, P43E variant Codon optimized

<400>  63
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcgaaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  64
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, P43E variant

<400>  64

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Glu Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  65
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L49E variant Codon optimized

<400>  65
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacgaaaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  66
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L49E variant

<400>  66

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Glu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  67
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L49K variant Codon optimized

<400>  67
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacaaaaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  68
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L49K variant

<400>  68

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Lys Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  69
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L49Q variant Codon optimized

<400>  69
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taaccaaaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  70
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L49Q variant

<400>  70

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Gln Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  71
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, K50T variant Codon optimized

<400>  71
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgact ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  72
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, K50T variant

<400>  72

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Thr Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  73
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L51I variant Codon optimized

<400>  73
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag attgtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  74
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L51I variant

<400>  74

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Ile Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  75
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, Q55E variant Codon optimized

<400>  75
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctgaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  76
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, Q55E variant

<400>  76

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Glu Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  77
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, Q55P variant Codon optimized

<400>  77
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctccaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  78
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, Q55P variant

<400>  78

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Pro Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  79
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N56E variant Codon optimized

<400>  79
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaagaaaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  80
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N56E variant

<400>  80

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Glu Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  81
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N57D variant Codon optimized

<400>  81
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacga tccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  82
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N57D variant

<400>  82

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asp Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  83
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N57E variant Codon optimized

<400>  83
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacga accattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  84
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N57E variant

<400>  84

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Glu Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  85
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L59E variant Codon optimized

<400>  85
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccagaatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  86
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L59E variant

<400>  86

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Glu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  87
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, M61H variant Codon optimized

<400>  87
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

cattctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  88
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, M61H variant

<400>  88

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr His Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  89
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, M61S variant Codon optimized

<400>  89
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

tcttctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  90
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, M61S variant

<400>  90

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Ser Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  91
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, M61W variant Codon optimized

<400>  91
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

tggtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  92
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, M61W variant

<400>  92

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Trp Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  93
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S62N variant Codon optimized

<400>  93
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgaatgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  94
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S62N variant

<400>  94

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Asn Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  95
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S62Q variant Codon optimized

<400>  95
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgcaagtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  96
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S62Q variant

<400>  96

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Gln Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  97
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, V63M variant Codon optimized

<400>  97
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctatgt taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  98
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, V63M variant

<400>  98

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Met Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  99
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S66D variant Codon optimized

<400>  99
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaacgatac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  100
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S66D variant

<400>  100

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Asp Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  101
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L71A variant Codon optimized

<400>  101
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac gctcgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  102
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L71A variant

<400>  102

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Ala Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  103
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L71H variant Codon optimized

<400>  103
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac catcgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  104
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L71H variant

<400>  104

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn His Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  105
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L71Q variant Codon optimized

<400>  105
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac caacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  106
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L71Q variant

<400>  106

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Gln Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  107
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S75D variant Codon optimized

<400>  107
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca ctgatgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  108
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S75D variant

<400>  108

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Asp Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  109
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S75E variant Codon optimized

<400>  109
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca ctgaagatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  110
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S75E variant

<400>  110

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Glu Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  111
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, I97V variant Codon optimized

<400>  111
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccgt tttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  112
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, I97V variant

<400>  112

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Val Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  113
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L98V variant Codon optimized

<400>  113
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cgtttgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  114
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L98V variant

<400>  114

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Val Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  115
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S100A variant Codon optimized

<400>  115
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgtgct      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  116
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S100A variant

<400>  116

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ala Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  117
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, V103A variant Codon optimized

<400>  117
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggctg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  118
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, V103A variant

<400>  118

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Ala Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  119
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, V103F variant Codon optimized

<400>  119
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaagtttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  120
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, V103F variant

<400>  120

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Phe Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  121
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, T109V variant Codon optimized

<400>  121
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtgttaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  122
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, T109V variant

<400>  122

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Val Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  123
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, Q124D variant Codon optimized

<400>  123
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccg atgtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  124
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, Q124D variant

<400>  124

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Asp Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  125
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, Q124E variant Codon optimized

<400>  125
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccg aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  126
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, Q124E variant

<400>  126

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Glu Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  127
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, Q124N variant Codon optimized

<400>  127
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttcca atgtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  128
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, Q124N variant

<400>  128

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Asn Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  129
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, V125E variant Codon optimized

<400>  129
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagaaccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  130
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, V125E variant

<400>  130

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Glu Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  131
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, V125Q variant Codon optimized

<400>  131
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aacaaccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  132
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, V125Q variant

<400>  132

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Gln Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  133
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, I129V variant Codon optimized

<400>  133
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcgttgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  134
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, I129V variant

<400>  134

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Val Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  135
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L132M variant Codon optimized

<400>  135
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacatgagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  136
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L132M variant

<400>  136

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Met Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  137
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S137G variant Codon optimized

<400>  137
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgtgg tatcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  138
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S137G variant

<400>  138

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Gly Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  139
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, H143D variant Codon optimized

<400>  139
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtcgatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  140
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, H143D variant

<400>  140

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val Asp Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  141
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, V149I variant Codon optimized

<400>  141
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttggattgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  142
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, V149I variant

<400>  142

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Ile Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  143
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, W161K variant Codon optimized

<400>  143
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

aaagttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  144
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, W161K variant

<400>  144

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Lys Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  145
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, W161R variant Codon optimized

<400>  145
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

agagttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  146
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, W161R variant

<400>  146

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Arg Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  147
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, W161Y variant Codon optimized

<400>  147
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tatgttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  148
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, W161Y variant

<400>  148

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Tyr Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  149
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, K165A variant Codon optimized

<400>  149
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg aggctaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  150
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, K165A variant

<400>  150

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Ala Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  151
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, E167P variant Codon optimized

<400>  151
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatcc aaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  152
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, E167P variant

<400>  152

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Pro Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  153
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N168S variant Codon optimized

<400>  153
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gtctttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  154
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N168S variant

<400>  154

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Ser Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  155
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S170T variant Codon optimized

<400>  155
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttaact ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  156
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S170T variant

<400>  156

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Thr Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  157
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L171I variant Codon optimized

<400>  157
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct attgctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  158
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L171I variant

<400>  158

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Ile Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  159
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, A172V variant Codon optimized

<400>  159
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggttgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  160
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, A172V variant

<400>  160

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Val Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  161
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, Y175F variant Codon optimized

<400>  161
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gtttttgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  162
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, Y175F variant

<400>  162

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Phe Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  163
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, C180A variant Codon optimized

<400>  163
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgttgct      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  164
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, C180A variant

<400>  164

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Ala Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  165
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, A181V variant Codon optimized

<400>  165
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gttggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  166
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, A181V variant

<400>  166

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Val Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  167
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N196Q variant Codon optimized

<400>  167
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtcaata cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  168
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N196Q variant

<400>  168

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Gln Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  169
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N196T variant Codon optimized

<400>  169
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtactta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  170
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N196T variant

<400>  170

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Thr Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  171
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N196V variant Codon optimized

<400>  171
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtgttta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  172
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N196V variant

<400>  172

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Val Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  173
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, H208T variant Codon optimized

<400>  173
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc cactttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  174
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, H208T variant

<400>  174

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala Thr 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  175
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, A235P variant Codon optimized

<400>  175
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtccagaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  176
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, A235P variant

<400>  176

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Pro Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  177
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, A250T variant Codon optimized

<400>  177
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttact gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  178
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, A250T variant

<400>  178

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Thr Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  179
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, M256V variant Codon optimized

<400>  179
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactgtttt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  180
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, M256V variant

<400>  180

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Val 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  181
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, K260C variant Codon optimized

<400>  181
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgtttgt      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  182
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, K260C variant

<400>  182

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Cys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  183
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, K260W variant Codon optimized

<400>  183
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgtttgg      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  184
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, K260W variant

<400>  184

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Trp Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  185
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L268I variant Codon optimized

<400>  185
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gattgttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  186
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L268I variant

<400>  186

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Ile Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  187
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, H309V variant Codon optimized

<400>  187
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattgttact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  188
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, H309V variant

<400>  188

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile Val Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  189
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, T310A variant Codon optimized

<400>  189
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacgct tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  190
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, T310A variant

<400>  190

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Ala Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  191
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, T310C variant Codon optimized

<400>  191
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcactgt tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  192
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, T310C variant

<400>  192

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Cys Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  193
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, F316Y variant Codon optimized

<400>  193
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgtttattt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  194
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, F316Y variant

<400>  194

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Tyr Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  195
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L326I variant Codon optimized

<400>  195
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatattat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  196
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L326I variant

<400>  196

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Ile Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  197
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, G378T variant Codon optimized

<400>  197
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tactgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  198
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, G378T variant

<400>  198

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Thr Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  199
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, G378S variant Codon optimized

<400>  199
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa ttctgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  200
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, G378S variant

<400>  200

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Ser Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  201
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, K389E variant Codon optimized

<400>  201
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taaggaacct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  202
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, K389E variant

<400>  202

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Glu Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  203
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, E406K variant Codon optimized

<400>  203
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaaaaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  204
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, E406K variant

<400>  204

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Lys Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  205
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S428L variant Codon optimized

<400>  205
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga attggccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  206
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, S428L variant

<400>  206

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Leu Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  207
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L439M variant Codon optimized

<400>  207
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcatgtac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  208
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L439M variant

<400>  208

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Met Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  209
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N466D variant Codon optimized

<400>  209
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctatgattt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  210
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N466D variant

<400>  210

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asp Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  211
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, K474S variant Codon optimized

<400>  211
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcct ctaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  212
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, K474S variant

<400>  212

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Ser Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  213
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, Y499M variant Codon optimized

<400>  213
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caatatgact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  214
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, Y499M variant

<400>  214

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Met Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  215
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, Y499V variant Codon optimized

<400>  215
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caatgttact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  216
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, Y499V variant

<400>  216

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Val Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  217
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N527E variant Codon optimized

<400>  217
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaga aaacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  218
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, N527E variant

<400>  218

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Glu Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  219
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, P538T variant Codon optimized

<400>  219
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc aactttgcct     1620

agacatagac actag                                                      1635


<210>  220
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, P538T variant

<400>  220

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Thr Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  221
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, R541E variant Codon optimized

<400>  221
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

gaacatagac actag                                                      1635


<210>  222
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, R541E variant

<400>  222

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Glu His Arg His 
    530                 535                 540                 


<210>  223
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, R541V variant Codon optimized

<400>  223
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

gttcatagac actag                                                      1635


<210>  224
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, R541V variant

<400>  224

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Val His Arg His 
    530                 535                 540                 


<210>  225
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, H542V variant Codon optimized

<400>  225
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agagttagac actag                                                      1635


<210>  226
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, H542V variant

<400>  226

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg Val Arg His 
    530                 535                 540                 


<210>  227
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, R543A variant Codon optimized

<400>  227
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatgctc actag                                                      1635


<210>  228
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, R543A variant

<400>  228

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Ala His 
    530                 535                 540                 


<210>  229
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, R543E variant Codon optimized

<400>  229
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatgaac actag                                                      1635


<210>  230
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, R543E variant

<400>  230

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Glu His 
    530                 535                 540                 


<210>  231
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, H544E variant Codon optimized

<400>  231
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagag aatag                                                      1635


<210>  232
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, H544E variant

<400>  232

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg Glu 
    530                 535                 540                 


<210>  233
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, H544D variant Codon optimized

<400>  233
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagag attag                                                      1635


<210>  234
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, H544D variant

<400>  234

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg Asp 
    530                 535                 540                 


<210>  235
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology ui1

<400>  235
gcttgtactg aaattaacga gaagattgct ttgtcgagac gtatcgaaaa gcattggcgt       60

ttgattggtt gggcaaccat taaaaagggt actacattgg aacccatcgc ttaaggaacc      120

aataaaacca ctgcaaagac aaaaatttca taattaatct gaaagaaagt gaagataaga      180

aacgggctag gaggaaggga aactgacact tctggttatt gcaatatgct catatacatt      240

gatgcgtaat gacattgatg atctttattc tctttttata acgttttctt tctttttttt      300

tccttcttac atagtattca actgtatatt taacatgttt tacgtatttt taagaaaaaa      360

ttactaaacg cgataatatt aagcaaatat ttatctcata gttctcgaac tcatttattt      420

cccattgatg ccatgaaaac ctctcaaacc tttatcgtct agttacacca gtagtcaata      480

aactgccttt ctttttttac                                                  500


<210>  236
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology di1

<400>  236
acaattgcac aaagataatg aagctccaaa attattcagt atctattgag tatatataac       60

cttgaaaagg ttttatttta tataagttcg ccatcttagt atagtggtta gtacacatcg      120

ttgtggccga tgaaaccctg gttcgattct aggagatggc atatttattt tttatattct      180

taatatacaa agaatgtcgt gtgaagctgt aggcacaggt aattttgtaa ccatagtcag      240

atgtggtgat catgagagcg aattataatt ttataccagc tggcaagaat tgagtaatat      300

ttagaccagc atataaaagt agaataaaaa gttatatgta caaatttttt ttgacgccag      360

gcatgaacaa aaactactat ggctttggaa ttttcaagct cttcgaaatc attccacacc      420

catggataaa aaatactaga ataattggat gaaattccaa tatttggtct tctctaaaaa      480

tgccgaatgg gatgttatca                                                  500


<210>  237
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology ui2

<400>  237
agttttgccg ctttgcttga tcactgttag tatttcggca aattatatgg tattggtcgc       60

cttgccaggt tctttaggaa gttcatcata aactaacgct ttcaagaatt tacggaaatg      120

atagggttta tagtttttat aacagtagtg gacctagaaa acaccgatag ctggcggcgg      180

ttatatctca ttactactat gaaaactgtg gctcctgagt agctactgaa ggatgtgccc      240

atcttaatcc agacctagtc aatacaatca atacaactgt ctagctgaaa actgacaaaa      300

aagtttgtcg atgtctctag tatattcact ataacactaa attttattgt aaattattac      360

acaagttttc aagaagaaaa acaatattaa acacaataac tagattatgc gaggcacggc      420

aaaaggagtg aagagggcaa aatacggaga agacaatata gaataaattt ctttttttga      480

ttagagaaga ttgtttgcca                                                  500


<210>  238
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology di2

<400>  238
atagtcttac catgatgatc agtcggattc tgacgacgtt gggtatttta aaacacgcgt       60

aattgaaagg gtgatgttga gaatggacca cttcaagata tgctcgaaaa tgtagctata      120

tttcacggat gaataactcg taagaatgtg cagtagctga tggacctagg aacgatcaag      180

tcaacgttgt attttggttc ggcaaacaat tgatatgatg ttgacaagaa aaccatctgc      240

gctctaatct ctaagtacac gtgcatttgg acctatcatc aaaagagaat aagaggatac      300

tttcaagaga agttcaaaaa agaatcatta ttatgatcca atgacagtga caataagatc      360

aacataaaaa agaaaagtca gaagtataaa tctgggtctt tttctctaaa ataattatag      420

tctgttaatt tataaaactg cctaaaaaat atacttaaaa tatgtctaca gattatgcag      480

ctggaaaaaa tcaagcaaaa                                                  500


<210>  239
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology ui3

<400>  239
ccagttatcc taggcaatta ctttatttga gtcttatatg acgtcactag aagctcagta       60

agagcaaccg agacctgaac atcctttttt ttttttgctt ctttatttgg cagcattttt      120

caaaaataat aaaatggaag ccgcgagtac gaacaatgat gtgttctggg aatacctcgt      180

caaaacaaga caatggtaag gattttcttt catcaggcag aaagatctgg atctgaatgg      240

catcattttg tgatgtgtaa aagcgggacc ttgttatttc gactttttgc atcatgttga      300

tgcaatttgc tacttttccg acggtgcgct ccaacggatg ggtatttcct taataacaag      360

gcatttctct ggaagttggc ttactgtttg aaatcacagc cggtcacaaa ataaagtaaa      420

aaaactatct ctctccacaa gaagtaatta caggttgtat actacgtgtg atcgtatttc      480

tttatgaaca ctaaggagtt                                                  500


<210>  240
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology di3

<400>  240
cgtgtctgaa aaatcttgaa ttttcagaaa agaataagcc ccaaatgtca gtgatggtag       60

tagcagtact cccctacgat tttagatact ttagagagcc caccttcaga atcggaagga      120

ggataatttt gtaaagccct tctgtttttt ctcttgcata acttatattt ccacatcaaa      180

aagtagtgtg ctaagaaaaa ggagacgaga aaaaggatta cggcactctc tgcatctaga      240

catataccaa aagttgggtt tgctcacgaa aataccataa ttgtggtgtc aaaaaaatcc      300

tgcctcataa taccactgca gcaattgtgg atgactaaaa aataacttgc attccacgat      360

gttattttac tttataaagc acctgcaatt tttttttttg tattaactca tcgagtatgt      420

ctgatgtgta aactgaacca ggcttaatat cgtttctaat tcttgttgtg agaaaacttt      480

cctgcctaat gtatttcgtc                                                  500


<210>  241
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology ui7

<400>  241
taaaatttta ctcatagtag ataatggcat aaatcagtgg taaaaaaaga atacgcatga       60

caaattttga aaaccgtacg tgacataaaa tacctataat aagatgaaga catcaattct      120

caagttccac ttttcgccgg ttgagtgtat cggtcatagt acaaaggcag aaatgaataa      180

tagtaatatt aatcgcagtt tcctgttgtt tagagaactg aaacgctttg tgggcatcag      240

gtttagatta actgctaccc ttcttctgta tttgtctggc catgcttctc aaataaaccg      300

ctgcggataa catttcaagt ggtttctcaa gggagaatca tagtttagct taacatacag      360

caaatcgtca ctatcttgac tgatgcccgg tgtatagaga atgggtagtt aatatcatct      420

agatggggtt tctttgaaaa caccagtttc tttgaggaca ccagtttcag tgcttctctc      480

taccccatca actattgcac                                                  500


<210>  242
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology di7

<400>  242
cgtcttgctt ttttcggtag tttttcgttt cgataaaggc aacaatgctg tatattgtat       60

gcaggaagtt cttaaggaaa atacaggaat ctttagaaaa agaataaata gctttccatt      120

gtatcatgaa caagtcactc ttcatattat atgtcgtcgc ttcttatccc tttaagttat      180

gaattgttga gcttaggatt ttaccacaac tgaataacat tttctttatt ctaataatcg      240

atttttttta ataagattag acttgagtgc catcagcaaa gaaaaatact tttaatgtcc      300

tttttttaac tctacacaga atttagttgg ctgtttcatt gatttacaaa aatataaata      360

tataccgtta aaattatagc gataaactga gtatgtggtc tctcttttcc cgcagaatat      420

gaaagctttt cttttataaa tcttataata ttggtctctt tttggtacgt ttggcaaatt      480

ggcattcatt tatcatgaaa                                                  500


<210>  243
<211>  503
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology ui10

<400>  243
aggaccactt catcaagttt cgaaagtgaa attaaatcca tttcagaaaa tttcaagaac       60

tctattccag aatcttccat actcttcagg atatcatata ataacaactc taataatacc      120

tctagtagcg agatcttcac acttttggta gaaaaagttt ggaattttga cgacttgata      180

atggcgatca attctaaaat ttcgaataca cataataaca acatttcacc aatcaccaag      240

atcaaatatc aggacgaaga tggggatttt gttgtgttag gtagcgatga agattggaat      300

gttgctaaag aaatgttggc ggaaaacaat gagaaattct tgaacattcg tctgtattga      360

taaataaaac tagtatacag caaatactaa ataattcaag aaaaaaacat tagatagaga      420

ggggcagatg ttcaagctat acccattata ttgatccaca cttagtatta agatacgtct      480

gtgaaggatg aaaaaaaatg tat                                              503


<210>  244
<211>  485
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology di10

<400>  244
ttgtgcgttt ttataatttt tttttttttg taattctatg caaatgtaat ataagtatat       60

ttaaagaaat aatgagtcct gtgaaaacaa aaagaaaaaa agatcattaa tgtatgttaa      120

cgtatttgct ttgcaaattt taatttattt gttgttaaat gcattttttt tttgtcgttt      180

cagcgagttt tcttgaggtt gctactatca ttaaaatcac aatccacaga ggaagttgat      240

ctctttttca gttgggtggg ggcagagcat gggtgagcag tggccatggg tctaacagga      300

aataatcttt ttgaacgcac agataaattt tgtaataatt ttctatttga cattagagat      360

ggggtggtgg gagttagtgg gcttggccaa aagatgcttg aattttgtgg gatgctcagt      420

gaccttttaa aagaattttg ggtagaagag aacgaacctg aatgtgaatg gtgtgatgca      480

gagtc                                                                  485


<210>  245
<211>  490
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology ui21

<400>  245
ccatctatcc ttcgcctctc cttcgctctg taattttttt tactcgcgcg cttccgactt       60

ttgaaagaag gagcaataaa gttaaataaa tgtaattaaa ttatgctttt ttaggcaagt      120

tcgggacttt gttgccacgt attgctcttc tatgcaagca cttcactcct tttctttcat      180

ctctgttttc ttccactggc tggaagcttg agggttgcct cttgattctt tatcgcctgc      240

aaccattgcc ttgttccgtc ctctcaaggc gttccttccg tgctttttaa atactagaat      300

cattcgagac gtatttatga gcatgttact tcttgatgtt tatctaagag ggttgtttag      360

gttatccgca ttatttttaa agttttaagg ttacatcatt tattcagacg cgttcggagg      420

agagtgcatt caccaagatg taaatttctt cagttttccg gattaggatt ggaaaaatga      480

agaaaaatag                                                             490


<210>  246
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology di21

<400>  246
ctaaagtaat tgtagcagtt gttattaagg agttctttaa atcatattgc ttgcttgtat       60

cagaccattg gaaacttcaa tgtttaaact ctagaaaggt tgatctgctc aaatattttc      120

atatttacgg catgtcctaa cttgaacatt tgtagaagag agacatattt cttagtgtag      180

gcaagatatt tgaatgacat tgtctgccga aatatactcg acttgcagtg gaactgcaag      240

tcgaaaagga tatcgcttta gccaaacaaa aatttgttgt gctattcagt gagcatgcat      300

tggctataga ggccgcacct aaattgtatc ttttgattta tgtaactgcc acactttctc      360

tagcacagtc atgatacggc tttttttcat ttagccacca aatactgtaa atatcgtttt      420

agaacgttat gaaaaaatgc tcatccactt aaaaacctct ccgtattctg aaagttggta      480

taatcttgca ctttaagtgt                                                  500


<210>  247
<211>  503
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology ui33

<400>  247
tctgttaacc attctggttc acttgccgtc gtatgttgcg gaccacctat tttcgtcgac       60

accgctagaa atcaaactgc caaagctgtt atcagaaacc catcaagaat gattgaatac      120

ttggaggaat accaagcctg gtgaacaatt tttcatattt aagtaaacac tcaatgtata      180

atatcctcta actgttgtaa tttcattaac gtaaatggtt tgcgcctttt ttaggggacc      240

cttgttgatt cattctaact actgaggcat aagttgtttc aaataacact ttttcagaaa      300

aataatcgta ttaaaaagca gaaaaatcat acgtaagatg acagaagctt catatttagt      360

aactctgaat tgtataacac accaattgcc gatagaatat gaaccaatcg atcttcagcg      420

ttcatgtact taatttaact acctgtattt tcttataaag ataaaattgg tgtataatgt      480

aagggccaag agaaaaagga atc                                              503


<210>  248
<211>  494
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology di33

<400>  248
atttcttcaa aaaaataact gaataaacac ctatataatg ttcagaggtt atactttagt       60

gttttagaat gcagtaccaa aagtaatata ttgaattaat aactatatga tgtgtagcta      120

agaattaaat agtaaacgtc ttctgaaacc ttttaagagg taattattgg tattccaaag      180

tcatatgtgg aggtaaggga gacacaaaat tatctggaat gacagcgtgc tgacacatat      240

aaagttccgt aacttcaaat gccttcatta ttcaacatag gaaaagtgaa atgtgtgcct      300

ctaaaatata cggaacatcg tcgaactaaa aaaatccatt aagcaaagtt agaaacagca      360

tgcactacaa gacatttggt tcatcatgaa gaatgctcaa ttgaaccatc aatcactttc      420

tcttgttcga tgttagcatt atcctcacta tcagttgaat cctcaatgct ttcggtttca      480

gtcctcgcat cttc                                                        494


<210>  249
<211>  502
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology ui34

<400>  249
tgagcaacca atcacttctg aaaccgctat gaagaaggtt gaagatggta acattttggt       60

tttccaagtt tccatgaaag ctaacaaata ccaaatcaag aaggccgtca aggaattata      120

cgaagttgac gtattgaagg ttaacacttt ggttagacca aacggtacca agaaggctta      180

cgttagattg actgctgact acgatgcttt ggacattgct aacagaatcg gttacattta      240

atctaattgg tttaattaat aaatttaata ttatttttaa atttttcttt aaatatacaa      300

taaatctttc ataacatgtt aaattcatga ttaagcgtaa ataaagtgta gtggcagagt      360

gcacggggtt tcctgtgcct tacaaagtag gtaccaattt gcgtattgca gcgagggttc      420

cggttactat ttataattac gtgttagtgt actgtgattt tattgaggct ataacaagaa      480

aaggatctgt gaaggttttg ag                                               502


<210>  250
<211>  492
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology di34

<400>  250
cccttttctt ttcgcaagat gagagtaaag agttgtacat caggtaagaa tgttattatt       60

taaattcgaa gtgataaatt cttttcatga tgaatcactc gcttatatgg ggtagaatat      120

atatatatgt gtgtgtgtgt gtgtgtttgt gtatgtaggg atggtgcgcg tttgttgtgt      180

gacatttgct actcattctt ttccttttcc tacgactggc ttaacgggaa tattatcaat      240

ttgctgcatt cttatgcttc ggtccgatgc tcattaagat gatgcagatc tcgatgcaac      300

gaattccaag cccttatcga tatttttctt taactgggag acgcaaattg gcaacatttg      360

gttgcgttcc atgtcgttca tcctattaac gatgtcataa tccacatagg aaacaccctt      420

tgtagtaata gttaatggta tggcaaagta gtctgcaccg tccaccagag gcaataattg      480

atctgcccca gg                                                          492


<210>  251
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology ui1001

<400>  251
atgagttaac gtagattact ttccgttagt gtaacggaca agatgacaca gtattgaaac       60

gctcctctat ctttgtgggt gttgagggag gagagagtta ttagtctaga cgctatatat      120

cacagagtcg agtgcccaat aatatagcag gtagacgcca acttaactac tggatgtgag      180

ttagagagga atatactgtt ttattaactc gtaccgtagt ggtttctggc gagaattcgc      240

cggcttaaaa tctattgact aactagaatt agcttaaagt ggaccttatt gaatctcacc      300

gggttatcgc gacatttata ttatcgaagg gtccagcttg gggtttgttt ggaaggttga      360

cttgttgttg tagttgtatc actaataatt acgattctca acgaccggcc caaagattgc      420

ctgggttaaa ttcagcgtct gatgtatact tagctcttcg caagtagtgt tctaattaaa      480

gatcacttca acttatcttc                                                  500


<210>  252
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology di1001

<400>  252
aaggtaactt aggctgacga cgcaataatg cacgctcgcg tgtgatgaga ttacatcagt       60

aagaattcat atctcgatat gggataatta cgggctcaca ctctaggaat accaagaaca      120

gtaatgtttc cttattaata tgtagataag gatcttctta aagtttaatt gatggcgaat      180

tccaaatagt gacttaactt tcgcgcagag tatcgcagga caaggttagc ttttcgtaag      240

cctgatgtta tgccataact agccaccttg taatccccgc gctcagtaaa tctatctact      300

tatttgcttc acttcttcac ggagagtact gattttcttc tctcaatact actgactacc      360

ttagggcgac atactttagt tctgcataag cgtcaacctc ttgcctaagg gtatggatcc      420

ttgttaagcc ttattccata tagttgagct gaagaacaga tccctcaact cgagtgcgac      480

tagtagctag ttacgaacac                                                  500


<210>  253
<211>  508
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology uPEP4

<400>  253
tgttaatccg ttttcaatat cttgagctcc tcaattgtat ttgctgaggt ctgattattt       60

ctataaccaa aagcggttat tgaatctatg gagaggctgt aacccgtctt atgccttccg      120

ggtactatat ttcatttgcg ggtgtcgatg gattaagggg cggaggcggc cctttttagg      180

atttatataa aaagccatac ttccgtactt cgtaacctct tatcaactgg ttaagggaac      240

agagtaaaga agtttgggta attcgctgct atttattcat tccaccttct tcttttttga      300

gcgaagcctt tataatcaaa ttttagtggt cttttctatt tttatttgag aagcctacca      360

cgtaagggaa gaataacaaa aagtatatct caccctactg tattcataaa aagttttttc      420

tattagaatt ctataagaaa agaaaaaaaa aaagcctagt gacctagtat ttaatccaaa      480

taaaattcaa acaaaaacca aaactaac                                         508


<210>  254
<211>  509
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology dPEP4

<400>  254
gctaaacttt tcttacttct ccgccctatc cttttctgcc atctagagag cttttataag       60

tagataacaa taaaaaaaac tatagtatat ttaaaaaaaa aaaacaagac aaaccatctt      120

gtcctcagtt ttagaatcca ttgttctatg ctgctgccca taatgtcatt atatgcgggt      180

agcccgatga tgcggctcga gaatttcctt gtttatcctt ttccaatagc ggaacaattg      240

ataataaagc aatgtaagca gaagcgaaaa ataaaaagaa ataggctgca gagattcaca      300

ggctgcgctc tagaaacatt tgaaatcaag gcaaacatag aacacttgat aaaattctta      360

ccataatacc accattgatg attcaaaaaa tgagcccaag cttaaggagg ccatcaacga      420

ggtctagttc tggttcaagt aatatcccac aatcgccctc tgtacgatca acttcatcgt      480

tttctaatct gacaagaaac tccatacgg                                        509


<210>  255
<211>  503
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology uROT2

<400>  255
gctgcattct tcagtggtat gttatttatg taacgggtat gcgaaccaca acgccagatt       60

cttgaagggg aaacctaact acacagtctt agcaacaacc gccggcgctc tgggtctttt      120

gacgctggac ggtataattt caaagaaata ctactccaga tacgacaaga aataataaca      180

tactatttaa taacatcctt ttcacacact cacacactca catactttat atacatatat      240

ttttataact attactgctg atttatttgt aaggaaacgt gctttcctct tcatcggtca      300

agtgataagt ttctataata taatagcttt tctgtctact atcattcttt tttcatttca      360

agtaccctta atttgtttta cccggaccac gaaattttct cactacggca cttgagagct      420

ataactcaat gaacatgttg cttggagtga tttgattgct ctgcgtatct taaaatagcg      480

gtctcgaatc aaccgtatgc aac                                              503


<210>  256
<211>  499
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology dROT2

<400>  256
gggaaaaaaa cgaaggggta tctttacatc tttttagctc tttcttgcaa attaaacgta       60

aaaatatccg taaatataac atataaccat tatctataga aaaaaagaac cgaaaattgt      120

gtcaggccct acttcccgtg agctaacttc attcttgtcg aaaacttgac tagggtcgtc      180

cagtcgcaaa acgtatcaca tttcggacat ttcccacctc gaggtatcaa gtttcttctc      240

cctactatca actgttcatc atctagaaag tacctgtgaa gacatttcaa gtggttaaca      300

gacccgcagt ctttattatt gcaaagcgct acaaacggct tcagattttg ctcttcagac      360

gtgtagtcaa tttctttctc acaaatttca catcgcacta cccctgtagt tagtttcttt      420

tcgaaagttt cgaatatgtt tctttcattt tcaatgactt tagtgtatac agcttctacc      480

acttttaaat tctcatcac                                                   499


<210>  257
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker D0

<400>  257
atcgacgggc cggccagtgt ctctcgttta aacttg                                 36


<210>  258
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker D2

<400>  258
atgagtatgc tatactccca ctaatggcat cacgct                                 36


<210>  259
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker D3

<400>  259
taggcaagaa tagcggagca ctaggtttcg acttaa                                 36


<210>  260
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker D4

<400>  260
acgatccacg gcttctaaag actgacaatt gctttc                                 36


<210>  261
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker D9

<400>  261
caaagctagg ccggccctta gtactagttt aaaccg                                 36


<210>  262
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker D20

<400>  262
tcggagcaaa tgaaacgatt ccgataagtg ttgcaa                                 36


<210>  263
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker D21

<400>  263
ttgtgggtga aagaaggaga ggtacgtttc tatcgt                                 36


<210>  264
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker D22

<400>  264
agacagaccc gccttaatct acaagattcg tgacat                                 36


<210>  265
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker D23

<400>  265
cattatattt cctacggagt cggaagcagg gacgta                                 36


<210>  266
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker D30

<400>  266
ggaccaccag taacactcca attctgggtg atttac                                 36


<210>  267
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker DH7

<400>  267
ctcttattac cctatcctat ggtactttct cggcag                                 36


<210>  268
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker G1

<400>  268
acctctatac tttaacgtca aggagaaaaa actata                                 36


<210>  269
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker G7

<400>  269
catgataaaa aaaaacagtt gaatattccc tcaaaa                                 36


<210>  270
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker G10

<400>  270
aaaaaaaaag taagaatttt tgaaaattca atataa                                 36


<210>  271
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker RG1

<400>  271
tatagttttt tctccttgac gttaaagtat agaggt                                 36


<210>  272
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker LTTDH1

<400>  272
ataaagcaat cttgatgagg ataatgattt tttttt                                 36


<210>  273
<211>  635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Promoter pGAL1

<400>  273
tttggatgga cgcaaagaag tttaataatc atattacatg gcaataccac catatacata       60

tccatatcta atcttactta tatgttgtgg aaatgtaaag agccccatta tcttagccta      120

aaaaaacctt ctctttggaa ctttcagtaa tacgcttaac tgctcattgc tatattgaag      180

tacggattag aagccgccga gcgggcgaca gccctccgac ggaagactct cctccgtgcg      240

tcctggtctt caccggtcgc gttcctgaaa cgcagatgtg cctcgcgccg cactgctccg      300

aacaataaag attctacaat actagctttt atggttatga agaggaaaaa ttggcagtaa      360

cctggcccca caaaccttca aatcaacgaa tcaaattaac aaccatagga taataatgcg      420

attagttttt tagccttatt tctggggtaa ttaatcagcg aagcgatgat ttttgatcta      480

ttaacagata tataaatgca aaagctgcat aaccacttta actaatactt tcaacatttt      540

cggtttgtat tacttcttat tcaaatgtca taaaagtatc aacaaaaaat tgttaatata      600

cctctatact ttaacgtcaa ggagaaaaaa ctata                                 635


<210>  274
<211>  668
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Promoter pGAL1-10

<400>  274
tatagttttt tctccttgac gttaaagtat agaggtatat taacaatttt ttgttgatac       60

ttttatgaca tttgaataag aagtaataca aaccgaaaat gttgaaagta ttagttaaag      120

tggttatgca gcttttgcat ttatatatct gttaatagat caaaaatcat cgcttcgctg      180

attaattacc ccagaaataa ggctaaaaaa ctaatcgcat tattatccta tggttgttaa      240

tttgattcgt tgatttgaag gtttgtgggg ccaggttact gccaattttt cctcttcata      300

accataaaag ctagtattgt agaatcttta ttgttcggag cagtgcggcg cgaggcacat      360

ctgcgtttca ggaacgcgac cggtgaagac caggacgcac ggaggagagt cttccgtcgg      420

agggctgtcg cccgctcggc ggcttctaat ccgtacttca atatagcaat gagcagttaa      480

gcgtattact gaaagttcca aagagaaggt ttttttaggc taagataatg gggctcttta      540

catttccaca acatataagt aagattagat atggatatgt atatggtggt attgccatgt      600

aatatgatta ttaaacttct ttgcgtccat ccaaaaaaaa agtaagaatt tttgaaaatt      660

caatataa                                                               668


<210>  275
<211>  465
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Promoter pGAL7

<400>  275
ggacggtagc aacaagaata tagcacgagc cgcgaagttc atttcgttac ttttgatatc       60

gctcacaact attgcgaagc gcttcagtga aaaaatcata aggaaaagtt gtaaatatta      120

ttggtagtat tcgtttggta aagtagaggg ggtaattttt cccctttatt ttgttcatac      180

attcttaaat tgctttgcct ctccttttgg aaagctatac ttcggagcac tgttgagcga      240

aggctcatta gatatatttt ctgtcatttt ccttaaccca aaaataaggg aaagggtcca      300

aaaagcgctc ggacaactgt tgaccgtgat ccgaaggact ggctatacag tgttcacaaa      360

atagccaagc tgaaaataat gtgtagctat gttcagttag tttggctagc aaagatataa      420

aagcaggtcg gaaatattta tgggcattat tatgcagagc atcaa                      465


<210>  276
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Promoter pTDH3

<400>  276
ttagtcaaaa aattagcctt ttaattctgc tgtaacccgt acatgcccaa aatagggggc       60

gggttacaca gaatatataa catcgtaggt gtctgggtga acagtttatt cctggcatcc      120

actaaatata atggagcccg ctttttaagc tggcatccag aaaaaaaaag aatcccagca      180

ccaaaatatt gttttcttca ccaaccatca gttcataggt ccattctctt agcgcaacta      240

cagagaacag gggcacaaac aggcaaaaaa cgggcacaac ctcaatggag tgatgcaacc      300

tgcctggagt aaatgatgac acaaggcaat tgacccacgc atgtatctat ctcattttct      360

tacaccttct attaccttct gctctctctg atttggaaaa agctgaaaaa aaaggttgaa      420

accagttccc tgaaattatt cccctacttg actaataagt atataaagac ggtaggtatt      480

gattgtaatt ctgtaaatct atttcttaaa cttcttaaat tctactttta tagttagtct      540

tttttttagt tttaaaacac caagaactta gtttcgaata aacacacata aacaaacaaa      600


<210>  277
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Promoter pTEF1

<400>  277
gacagcctag acatcaatag tcatacaaca gaaagcgacc acccaacttt ggctgataat       60

agcgtataaa caatgcatac tttgtacgtt caaaatacaa tgcagtagat atatttatgc      120

atattacata taatacatat cacataggaa gcaacaggcg cgttggactt ttaattttcg      180

aggaccgcga atccttacat cacacccaat cccccacaag tgatccccca cacaccatag      240

cttcaaaatg tttctactcc ttttttactc ttccagattt tctcggactc cgcgcatcgc      300

cgtaccactt caaaacaccc aagcacagca tactaaattt cccctctttc ttcctctagg      360

gtgtcgttaa ttacccgtac taaaggtttg gaaaagaaaa aagagaccgc ctcgtttctt      420

tttcttcgtc gaaaaaggca ataaaaattt ttatcacgtt tctttttctt gaaaattttt      480

ttttttgatt tttttctctt tcgatgacct cccattgata tttaagttaa taaacggtct      540

tcaatttctc aagtttcagt ttcatttttc ttgttctatt acaacttttt ttacttcttg      600

ctcattagaa agaaagcata gcaatctaat ctaagtttta attacaaa                   648


<210>  278
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SRS SRS_A

<400>  278
gagatcccca aacagtttaa tctctgatta actcttgcgt cgtatagtcg ggcttaactc       60

tatactcaaa atcactaaca agacgtagac gcaagacgat aagaccgggc aggatactat      120

cactcaatac agttcagata tctccatcta actgtactct actcaaaaac gtcttactaa      180

agaagaacgt ctccccaaca catgtaggaa ggaagtgatt acttatcttt tggctaaatc      240

tacataatta gtcagcgaac attctagaca gagagtgaaa tctgacacgt gagattagtg      300

cttatactct gattaggctc agtgaaacta gctgtgcatg taccgtgatt attaggttga      360

cataggaatt tagtgcctaa tatcggctcg attataaata tcagtaattc gatatcgtca      420

tgtctttatg cttacaggta tagtaatttg gccttagtgg aacgatcaat cggcttctgt      480

aatattattc aaccttccct                                                  500


<210>  279
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SRS SRS_B

<400>  279
atcaatttgt gattactttg ctaggtaacg ccactactgg tgttataatt gctgttactt       60

aagcgccttg taatcgatat aagtgaaaat acaaaacgca gcctactgtt caatcggaac      120

tttagtatat tcgctgagga ctagtacgtg gcagaatcca gttataatgt tttgaatcgc      180

ttttaaggta ctgaagtaat ccacaggacg ccaagctctt atagcacagt gggatatatt      240

tgcacgtgat tattgcaaaa gagctaaggg tcgtacttca cgtcttttaa ctgagtacaa      300

cccaaatttg gttcgcttcg caagttgata gcgtagcgac acgtacagtt ggtttgaaac      360

agtagtactt ccttttaatt cggaggctta ttgtacggaa agtgttctgt taattaaggt      420

agaccagcag aacaccgcgc accagggatt gcatatcttt agggtatttc gagattgcat      480

cccattgaaa tcgtaccttt                                                  500


<210>  280
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SRS SRS_C

<400>  280
gaagactaac gaacgaggtg gtatatagtt accctatgta aaatcgttaa ttgtcattag       60

acaatgtttc aggagtagaa ttcagctagc tgttagccca ctggcacacg ctaggacgct      120

atcaggacgg tctttgaacc tataactcag tatatggttt tagacctata atctgcttct      180

aaggcacgcg ggggagtaac ttagatacta gtgcttccag gaaaatctgg cgcgataata      240

gcccgatctt ctaatagact atccctacca aaagttataa atcattgttc tcttgacgtt      300

aacatcactt gctgaaaatt agaatgtgaa gaaaaccata aacaaattag cctggcagac      360

agtgaatata ctctacgttg aacatataca aaaatagaag cgccggaaag aagatccttc      420

ccagtagagt ccgttaaact aatttcctaa ttgctaaata ctgtatctac ctgataatgg      480

ggtcggttac ttcagtttat                                                  500


<210>  281
<211>  497
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SRS SRS_D

<400>  281
ctcgtaactt gatttaataa cggaggctat tgaacttaaa atcgcatctg gctgttaaat       60

tcaataaact tgctttcagg ttaacttcct ttgattaagt cgtgaattaa gatcttatta      120

caactctggt acgtcctaag ttagattaaa gtactgttgg aggaacggaa taatatttct      180

tgtgttacgc agctagtgaa ccagtgtcac aggaggtgta acaaccggtt gaaattctaa      240

cttttgaagc tttacctaag ggtactgtat aaggatcaca ttgttagtac aacgctagtt      300

cgtaggcgtt caaacttaat tgtttagtag tccgcacttg actaactgac gctccttggt      360

ctgctcttcg taattaggct ttcgaaaggt acgatggaat actaagtata ataacagttg      420

tctgacaact acggtacgta tttgatgttg aggcagtgag ctaactccac ttagtgtgta      480

accttacgta tcatata                                                     497


<210>  282
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SRS SRS_G

<400>  282
atgagttaac gtagattact ttccgttagt gtaacggaca agatgacaca gtattgaaac       60

gctcctctat ctttgtgggt gttgagggag gagagagtta ttagtctaga cgctatatat      120

cacagagtcg agtgcccaat aatatagcag gtagacgcca acttaactac tggatgtgag      180

ttagagagga atatactgtt ttattaactc gtaccgtagt ggtttctggc gagaattcgc      240

cggcttaaaa tctattgact aactagaatt agcttaaagt ggaccttatt gaatctcacc      300

gggttatcgc gacatttata ttatcgaagg gtccagcttg gggtttgttt ggaaggttga      360

cttgttgttg tagttgtatc actaataatt acgattctca acgaccggcc caaagattgc      420

ctgggttaaa ttcagcgtct gatgtatact tagctcttcg caagtagtgt tctaattaaa      480

gatcacttca acttatcttc                                                  500


<210>  283
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SRS SRS_H

<400>  283
aaggtaactt aggctgacga cgcaataatg cacgctcgcg tgtgatgaga ttacatcagt       60

aagaattcat atctcgatat gggataatta cgggctcaca ctctaggaat accaagaaca      120

gtaatgtttc cttattaata tgtagataag gatcttctta aagtttaatt gatggcgaat      180

tccaaatagt gacttaactt tcgcgcagag tatcgcagga caaggttagc ttttcgtaag      240

cctgatgtta tgccataact agccaccttg taatccccgc gctcagtaaa tctatctact      300

tatttgcttc acttcttcac ggagagtact gattttcttc tctcaatact actgactacc      360

ttagggcgac atactttagt tctgcataag cgtcaacctc ttgcctaagg gtatggatcc      420

ttgttaagcc ttattccata tagttgagct gaagaacaga tccctcaact cgagtgcgac      480

tagtagctag ttacgaacac                                                  500


<210>  284
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SRS SRS_J

<400>  284
ggtcattgag gcggtaagaa tctgatttat ctagatctat agcaacgtca aataattcaa       60

atcccgtact tttcaagatt ctgagggtta aggtcttgat tgtgattcta aatacttgta      120

ggtaccgagt aatagacgcg cactcagatt tggtctaata cgattattta cccatagaga      180

gagtaatcgt ctatggcccg tagttagcaa ggttcaacgt gtattatgta ctgagtacgc      240

agatctgatt accctataat ttccaagata ttagtgattc taacggatat agtcaatacc      300

tcccaattcc ccacgcttcg attgtagtat ttgattcggc tgacaaacgc cgacaagatt      360

cgctgtaact ctttggctaa tagaaaagta aatcaacacg cgttcttaaa ttcttgacat      420

gtaagtactt ggaacaatct tacctgttat ccattatctg tttatcgatc ttacctaacc      480

atccagtttg cctgagtggg                                                  500


<210>  285
<211>  250
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Terminator tTDH1

<400>  285
ataaagcaat cttgatgagg ataatgattt ttttttgaat atacataaat actaccgttt       60

ttctgctaga ttttgtgaag acgtaaataa gtacatatta ctttttaagc caagacaaga      120

ttaagcatta actttaccct tttctcttct aagtttcaat actagttatc actgtttaaa      180

agttatggcg agaacgtcgg cggttaaaat atattaccct gaacgtggtg aattgaagtt      240

ctaggatggt                                                             250


<210>  286
<211>  301
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Terminator tENO1

<400>  286
agcttttgat taagccttct agtccaaaaa acacgttttt ttgtcattta tttcattttc       60

ttagaatagt ttagtttatt cattttatag tcacgaatgt tttatgattc tatatagggt      120

tgcaaacaag catttttcat tttatgttaa aacaatttca ggtttacctt ttattctgct      180

tgtggtgacg cgtgtatccg cccgctcttt tggtcaccca tgtatttaat tgcataaata      240

attcttaaaa gtggagctag tctatttcta tttacatacc tctcatttct catttcctcc      300

t                                                                      301


<210>  287
<211>  296
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Terminator tSSA1

<400>  287
gccaattggt gcggcaattg ataataacga aaatgtcttt taatgatctg ggtataatga       60

ggaattttcc gaacgttttt actttatata tatatataca tgtaacatat attctatacg      120

ctatagagaa aggaaatttt tcaattaaaa aaaaaataga gaaagagttt cacttcttga      180

ttatcgctaa cactaatggt tgaagtactg ctactttaat tttatagata ggcaaaaaaa      240

aattattcgg ggcgagctgg gaattgaacc cagggcctct cgcatgcttt gtcttc          296


<210>  288
<211>  250
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Terminator tADH1

<400>  288
gcgaatttct tatgatttat gatttttatt attaaataag ttataaaaaa aataagtgta       60

tacaaatttt aaagtgactc ttaggtttta aaacgaaaat tcttattctt gagtaactct      120

ttcctgtagg tcaggttgct ttctcaggta tagcatgagg tcgctcttat tgaccacacc      180

tctaccggca tgccgagcaa atgcctgcaa atcgctcccc atttcaccca attgtagata      240

tgctaactcc                                                             250


<210>  289
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Terminator tCYC1

<400>  289
atcatgtaat tagttatgtc acgcttacat tcacgccctc cccccacatc cgctctaacc       60

gaaaaggaag gagttagaca acctgaagtc taggtcccta tttatttttt tatagttatg      120

ttagtattaa gaacgttatt tatatttcaa atttttcttt tttttctgta cagacgcgtg      180

tacgcatgta acattatact gaaaaccttg cttgagaagg ttttgggacg ctcgaaggct      240

ttaatttgc                                                              249


<210>  290
<211>  509
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Terminator tHUG1

<400>  290
agtatgcttc tctttttttt tgtaggccag tgataggaaa gaacaataga atataaatac       60

gtcagaatat aatagatatg tttttatatt tagacctcgt acataggaat aattgacgtt      120

ttttttggcc aacatttgaa attttttttt gttacctcgc gctgagccca aacgggctcc      180

actacccgcc gcggtcgcca ttttgggaag tcatccgtcc caaaaaggaa atagccataa      240

catgtcgtta ctgttttgga acatcgcccg tttcgcccga ttccgcctca gcgggtataa      300

aaagagatct ttttttttcc tggctgtccc ttcccatttt taaatgtctt atctgctcct      360

ttgtgatctt acggtctcac taacctctct tcaactgctc aataatttcc cgctatgcaa      420

aattcccaag actactttta cgctcaaaat cgctcccaac aacaacaagc cccttccaca      480

ttgcgtaccg tgaccatggc ggaatttag                                        509


<210>  291
<211>  505
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Terminator tSPG5

<400>  291
aaagacgttg tttcatcgcg ctattaccaa gaaggttact ttacttgttc ttgcacatgg       60

acgcacgttg tgtgttcata tatatatata tatatatata tatatatttg tgcttgtttt      120

cattgtctct atagttaata cattctattt ttatcgttat atttgcattc tcttcgcata      180

aaaacttcat gaaaattcgg cagaaaataa gccatatatg tactttatcc ataggcaaag      240

aaaagcactt aacgagaata tacaacaatt gcactagtac tgcatgtata tactcttatg      300

attatagcgg caagaaaaca aatataaaca cactaacaga tgaattcgaa tgaagatata      360

catgaagaac gcattgaagt tccacgaact ccccatcaaa cccagccaga gaaagactct      420

gatcgcatcg ctctcaggga tgaaatatca gtaccagaag gcgatgaaaa agcatattcg      480

gatgagaaag tagaaatggc aacca                                            505


<210>  292
<211>  522
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Promoter pGAL10

<400>  292
atctgttaat agatcaaaaa tcatcgcttc gctgattaat taccccagaa ataaggctaa       60

aaaactaatc gcattattat cctatggttg ttaatttgat tcgttgattt gaaggtttgt      120

ggggccaggt tactgccaat ttttcctctt cataaccata aaagctagta ttgtagaatc      180

tttattgttc ggagcagtgc ggcgcgaggc acatctgcgt ttcaggaacg cgaccggtga      240

agaccaggac gcacggagga gagtcttccg tcggagggct gtcgcccgct cggcggcttc      300

taatccgtac ttcaatatag caatgagcag ttaagcgtat tactgaaagt tccaaagaga      360

aggttttttt aggctaagat aatggggctc tttacatttc cacaacatat aagtaagatt      420

agatatggat atgtatatgg tggtattgcc atgtaatatg attattaaac ttctttgcgt      480

ccatccaaaa aaaaagtaag aatttttgaa aattcaatat aa                         522


<210>  293
<211>  921
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  aromatic prenyltransferase (NphB-ScCO) nucleotide sequence

<400>  293
atgtctgagg cggcagacgt agagagagta tacgctgcta tggaggaagc ggctggatta       60

ttgggggtgg cttgtgccag agacaagata tatccgttac tgtctacttt ccaggacact      120

cttgtagaag gagggagtgt ggtggtgttt agtatggcat caggccgtca ttcaacagag      180

ctagatttca gtatatctgt gccaacaagt cacggtgatc catacgcaac cgtagtcgag      240

aagggtcttt tcccggcaac agggcatcct gtagatgatt tgcttgccga cacacagaag      300

cacctgcccg tctccatgtt cgcaatcgat ggtgaggtga ccggaggatt taaaaagact      360

tacgctttct tcccgactga caatatgcca ggagttgccg agttgagtgc aataccatcc      420

atgccgccag cagtcgcgga gaacgccgaa ttgttcgccc gttacggctt ggacaaagtc      480

caaatgacta gtatggacta taaaaagagg caggtgaatc tatatttcag cgaactttct      540

gcccaaacct tggaggcgga gagcgtttta gcccttgtta gggagttagg gctacacgtc      600

ccgaatgagt tgggtttgaa attttgtaag cgtagctttt cagtatatcc gacgctgaac      660

tgggaaactg gaaagattga caggctatgc tttgcagtga tttctaatga ccctacgctt      720

gtaccttcct cagacgaggg cgacatcgag aaattccaca actatgccac aaaagctccg      780

tatgcctacg tcggcgaaaa acgtactcta gtatacggtt tgactctgag tcccaaggaa      840

gagtattaca agctaggagc gtactatcat atcactgatg tgcaacgtgg cttgctgaaa      900

gccttcgact ccttagagga c                                                921


<210>  294
<211>  307
<212>  PRT
<213>  Unknown

<220>  
<223>  Streptomyces sp.

<400>  294

Met Ser Glu Ala Ala Asp Val Glu Arg Val Tyr Ala Ala Met Glu Glu 
1               5                   10                  15      


Ala Ala Gly Leu Leu Gly Val Ala Cys Ala Arg Asp Lys Ile Tyr Pro 
            20                  25                  30          


Leu Leu Ser Thr Phe Gln Asp Thr Leu Val Glu Gly Gly Ser Val Val 
        35                  40                  45              


Val Phe Ser Met Ala Ser Gly Arg His Ser Thr Glu Leu Asp Phe Ser 
    50                  55                  60                  


Ile Ser Val Pro Thr Ser His Gly Asp Pro Tyr Ala Thr Val Val Glu 
65                  70                  75                  80  


Lys Gly Leu Phe Pro Ala Thr Gly His Pro Val Asp Asp Leu Leu Ala 
                85                  90                  95      


Asp Thr Gln Lys His Leu Pro Val Ser Met Phe Ala Ile Asp Gly Glu 
            100                 105                 110         


Val Thr Gly Gly Phe Lys Lys Thr Tyr Ala Phe Phe Pro Thr Asp Asn 
        115                 120                 125             


Met Pro Gly Val Ala Glu Leu Ser Ala Ile Pro Ser Met Pro Pro Ala 
    130                 135                 140                 


Val Ala Glu Asn Ala Glu Leu Phe Ala Arg Tyr Gly Leu Asp Lys Val 
145                 150                 155                 160 


Gln Met Thr Ser Met Asp Tyr Lys Lys Arg Gln Val Asn Leu Tyr Phe 
                165                 170                 175     


Ser Glu Leu Ser Ala Gln Thr Leu Glu Ala Glu Ser Val Leu Ala Leu 
            180                 185                 190         


Val Arg Glu Leu Gly Leu His Val Pro Asn Glu Leu Gly Leu Lys Phe 
        195                 200                 205             


Cys Lys Arg Ser Phe Ser Val Tyr Pro Thr Leu Asn Trp Glu Thr Gly 
    210                 215                 220                 


Lys Ile Asp Arg Leu Cys Phe Ala Val Ile Ser Asn Asp Pro Thr Leu 
225                 230                 235                 240 


Val Pro Ser Ser Asp Glu Gly Asp Ile Glu Lys Phe His Asn Tyr Ala 
                245                 250                 255     


Thr Lys Ala Pro Tyr Ala Tyr Val Gly Glu Lys Arg Thr Leu Val Tyr 
            260                 265                 270         


Gly Leu Thr Leu Ser Pro Lys Glu Glu Tyr Tyr Lys Leu Gly Ala Tyr 
        275                 280                 285             


Tyr His Ile Thr Asp Val Gln Arg Gly Leu Leu Lys Ala Phe Asp Ser 
    290                 295                 300                 


Leu Glu Asp 
305         


<210>  295
<211>  3349
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  IRE1 fragment

<400>  295
atgcggtcta cttcgaagaa acatgttagt attgacactg ctcgtttgtg tgttttcatc       60

catcatttca tgctcaatcc cattgtcgtc tcgcacctca aggcggcaga tagtggaaga      120

tgaagttgcc tccactaaaa agctcaattt caactatggt gtggataaaa atataaactc      180

gcccattcct gctccaagaa ccactgaagg tttaccaaat atgaaactca gctcatatcc      240

aactcctaac ttattgaata ctgctgataa tcgacgtgct aacaaaaaag gacgtagggc      300

tgccaattct ataagtgtac cctatttgga gaatcgttcc ttgaacgaac tgagtttatc      360

agatatacta atcgcagccg acgttgaggg tggacttcat gctgtagata gaagaaatgg      420

tcatatcata tggtcaatcg aaccagaaaa ttttcaacct ctgatagaaa tacaagaacc      480

ttcgaggtta gaaacatatg aaacgttgat tatagaacct ttcggtgatg ggaacattta      540

ctactttaac gcccatcaag ggttacaaaa actgccttta tccatacgac aacttgtatc      600

aacttccccg ctgcacttga aaacaaatat tgtggttaat gactctggaa aaattgttga      660

agatgaaaag gtctacactg gatcgatgag aactataatg tatactataa acatgttgaa      720

tggtgaaatt atatcagcgt tcggacctgg ttcaaaaaac gggtatttcg ggagccagag      780

tgtggattgc tcacctgagg agaagataaa acttcaggaa tgtgaaaata tgattgtaat      840

aggcaaaact atttttgagc tgggaattca ctcttatgat ggagcaagct acaatgtcac      900

ttactctaca tggcagcaaa atgttttaga tgttccccta gcgcttcaga atacattttc      960

aaaggacggc atgtgcatag cgcctttccg tgataaatca ttgctagcaa gcgatttaga     1020

ttttagaatt gctagatggg tttctccgac attccccgga attattgttg ggcttttcga     1080

tgtgtttaat gatctccgca ccaatgaaaa tatactggta ccgcatccct ttaatcctgg     1140

tgatcatgaa agtatatcga gtaacaaagt ttacttggat cagacttcga acctctcctg     1200

gtttgcatta tctagtcaga attttccatc tttagtcgaa tcagctccca tatcaagata     1260

cgcttccagt gaccgttgga gggtgtcttc aatttttgaa gatgagactt tattcaagaa     1320

cgcaatcatg ggtgttcatc agatatataa taatgaatat gatcaccttt atgaaaacta     1380

tgaaaaaacg aatagtttgg acactacgca caaatatcca cctctgatga ttgattcgtc     1440

cgttgataca accgatttac atcagaataa cgagatgaat tcactaaagg aatacatgtc     1500

accagaagac cttgaggcat atagaaaaaa gatacacgag caaatatcga gagaattaga     1560

tgaaaagaac caaaattctt tgctactgaa gtttggaagt ctagtatatc gaattataga     1620

gactggagta tttctgttgt tatttctcat tttttgtgca atactacaaa gattcaaaat     1680

tttgccgcca ctatatgtat tattatccaa aattggattt atgcctgaaa aggaaatccc     1740

catagttgag tcgaaatcgc taaattgtcc ctcttcatcg gaaaatgtaa ccaagccatt     1800

cgatatgaaa tcagggaagc aagttgtttt tgaaggtgct gtgaacgatg gaagtctaaa     1860

atctgaaaaa gataacgatg atgctgatga agatgatgaa aaatcactag atttaaccac     1920

agaaaagaag aagaggaaaa gaggttcgag aggaggcaaa aagggccgaa aatcacgcat     1980

tgcaaatata ccaaactttg agcaatcttt aaaaaatttg gtagtatccg aaaaaatttt     2040

aggttacggt tcatcaggaa cagtagtttt tcagggaagt tttcaaggaa gacctgttgc     2100

ggtaaagaga atgttaattg atttttgtga catagcttta atggaaataa aacttttgac     2160

tgaaagcgat gatcacccta acgtcatacg atactactgt tcagaaacaa cagacagatt     2220

tttgtatatt gctttagagc tctgcaattt gaaccttcaa gatttggtgg agtctaagaa     2280

tgtatcagat gaaaacctga aattacagaa agagtataat ccaatttcgt tattgagaca     2340

aatagcgtcc ggggtagcac atttacattc tttaaagatt atccatcgag atttaaagcc     2400

tcaaaatatt ctcgtttcta cttcgagtag gtttactgcc gatcagcaaa caggagcaga     2460

aaatcttcga attttgatat cagactttgg tctttgcaaa aaactagact ctggtcagtc     2520

ttcatttaga acaaatttga ataacccttc tggcacaagt ggttggaggg ccccagagct     2580

gcttgaagaa tcaaacaatt tgcagtgcca agtcgaaacg gaacactctt ctagtaggca     2640

tacagtagtt tcatctgatt ctttttatga tccgttcacc aagaggaggc taacaagatc     2700

tattgatatt ttttctatgg gatgtgtatt ctattatatc ctatccaaag ggaagcatcc     2760

atttggagat aaatattcac gtgaaagcaa tatcataaga ggaatattca gtcttgatga     2820

aatgaaatgt ctacatgata gatccttaat tgcagaagct acagatctga tctcccaaat     2880

gattgatcac gatccgttaa aaagacctac tgctatgaaa gttctaaggc atccgttgtt     2940

ttggccaaag tcgaaaaaat tggagttcct tttaaaagtt agtgataggc ttgaaattga     3000

aaacagagac cctccaagtg ccctgttaat gaaatttgac gccggttctg actttgtaat     3060

acccagtgga gattggactg tcaagtttga taaaacattc atggacaacc ttgaaaggta     3120

cagaaaatac cattcatcaa agttaatgga tctattaaga gcacttagga ataaatatca     3180

tcattttatg gatttacctg aagatatagc agaactaatg gggccggtac ccgatggatt     3240

ttacgattac ttcaccaagc gttttccaaa cctattaata ggtgtttata tgattgtcaa     3300

ggaaaattta agtgacgatc aaattttacg tgaatttttg tattcataa                 3349


<210>  296
<211>  1108
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IRE1 fragment

<400>  296

Met Leu Val Leu Thr Leu Leu Val Cys Val Phe Ser Ser Ile Ile Ser 
1               5                   10                  15      


Cys Ser Ile Pro Leu Ser Ser Arg Thr Ser Arg Arg Gln Ile Val Glu 
            20                  25                  30          


Asp Glu Val Ala Ser Thr Lys Lys Leu Asn Phe Asn Tyr Gly Val Asp 
        35                  40                  45              


Lys Asn Ile Asn Ser Pro Ile Pro Ala Pro Arg Thr Thr Glu Gly Leu 
    50                  55                  60                  


Pro Asn Met Lys Leu Ser Ser Tyr Pro Thr Pro Asn Leu Leu Asn Thr 
65                  70                  75                  80  


Ala Asp Asn Arg Arg Ala Asn Lys Lys Gly Arg Arg Ala Ala Asn Ser 
                85                  90                  95      


Ile Ser Val Pro Tyr Leu Glu Asn Arg Ser Leu Asn Glu Leu Ser Leu 
            100                 105                 110         


Ser Asp Ile Leu Ile Ala Ala Asp Val Glu Gly Gly Leu His Ala Val 
        115                 120                 125             


Asp Arg Arg Asn Gly His Ile Ile Trp Ser Ile Glu Pro Glu Asn Phe 
    130                 135                 140                 


Gln Pro Leu Ile Glu Ile Gln Glu Pro Ser Arg Leu Glu Thr Tyr Glu 
145                 150                 155                 160 


Thr Leu Ile Ile Glu Pro Phe Gly Asp Gly Asn Ile Tyr Tyr Phe Asn 
                165                 170                 175     


Ala His Gln Gly Leu Gln Lys Leu Pro Leu Ser Ile Arg Gln Leu Val 
            180                 185                 190         


Ser Thr Ser Pro Leu His Leu Lys Thr Asn Ile Val Val Asn Asp Ser 
        195                 200                 205             


Gly Lys Ile Val Glu Asp Glu Lys Val Tyr Thr Gly Ser Met Arg Thr 
    210                 215                 220                 


Ile Met Tyr Thr Ile Asn Met Leu Asn Gly Glu Ile Ile Ser Ala Phe 
225                 230                 235                 240 


Gly Pro Gly Ser Lys Asn Gly Tyr Phe Gly Ser Gln Ser Val Asp Cys 
                245                 250                 255     


Ser Pro Glu Glu Lys Ile Lys Leu Gln Glu Cys Glu Asn Met Ile Val 
            260                 265                 270         


Ile Gly Lys Thr Ile Phe Glu Leu Gly Ile His Ser Tyr Asp Gly Ala 
        275                 280                 285             


Ser Tyr Asn Val Thr Tyr Ser Thr Trp Gln Gln Asn Val Leu Asp Val 
    290                 295                 300                 


Pro Leu Ala Leu Gln Asn Thr Phe Ser Lys Asp Gly Met Cys Ile Ala 
305                 310                 315                 320 


Pro Phe Arg Asp Lys Ser Leu Leu Ala Ser Asp Leu Asp Phe Arg Ile 
                325                 330                 335     


Ala Arg Trp Val Ser Pro Thr Phe Pro Gly Ile Ile Val Gly Leu Phe 
            340                 345                 350         


Asp Val Phe Asn Asp Leu Arg Thr Asn Glu Asn Ile Leu Val Pro His 
        355                 360                 365             


Pro Phe Asn Pro Gly Asp His Glu Ser Ile Ser Ser Asn Lys Val Tyr 
    370                 375                 380                 


Leu Asp Gln Thr Ser Asn Leu Ser Trp Phe Ala Leu Ser Ser Gln Asn 
385                 390                 395                 400 


Phe Pro Ser Leu Val Glu Ser Ala Pro Ile Ser Arg Tyr Ala Ser Ser 
                405                 410                 415     


Asp Arg Trp Arg Val Ser Ser Ile Phe Glu Asp Glu Thr Leu Phe Lys 
            420                 425                 430         


Asn Ala Ile Met Gly Val His Gln Ile Tyr Asn Asn Glu Tyr Asp His 
        435                 440                 445             


Leu Tyr Glu Asn Tyr Glu Lys Thr Asn Ser Leu Asp Thr Thr His Lys 
    450                 455                 460                 


Tyr Pro Pro Leu Met Ile Asp Ser Ser Val Asp Thr Thr Asp Leu His 
465                 470                 475                 480 


Gln Asn Asn Glu Met Asn Ser Leu Lys Glu Tyr Met Ser Pro Glu Asp 
                485                 490                 495     


Leu Glu Ala Tyr Arg Lys Lys Ile His Glu Gln Ile Ser Arg Glu Leu 
            500                 505                 510         


Asp Glu Lys Asn Gln Asn Ser Leu Leu Leu Lys Phe Gly Ser Leu Val 
        515                 520                 525             


Tyr Arg Ile Ile Glu Thr Gly Val Phe Leu Leu Leu Phe Leu Ile Phe 
    530                 535                 540                 


Cys Ala Ile Leu Gln Arg Phe Lys Ile Leu Pro Pro Leu Tyr Val Leu 
545                 550                 555                 560 


Leu Ser Lys Ile Gly Phe Met Pro Glu Lys Glu Ile Pro Ile Val Glu 
                565                 570                 575     


Ser Lys Ser Leu Asn Cys Pro Ser Ser Ser Glu Asn Val Thr Lys Pro 
            580                 585                 590         


Phe Asp Met Lys Ser Gly Lys Gln Val Val Phe Glu Gly Ala Val Asn 
        595                 600                 605             


Asp Gly Ser Leu Lys Ser Glu Lys Asp Asn Asp Asp Ala Asp Glu Asp 
    610                 615                 620                 


Asp Glu Lys Ser Leu Asp Leu Thr Thr Glu Lys Lys Lys Arg Lys Arg 
625                 630                 635                 640 


Gly Ser Arg Gly Gly Lys Lys Gly Arg Lys Ser Arg Ile Ala Asn Ile 
                645                 650                 655     


Pro Asn Phe Glu Gln Ser Leu Lys Asn Leu Val Val Ser Glu Lys Ile 
            660                 665                 670         


Leu Gly Tyr Gly Ser Ser Gly Thr Val Val Phe Gln Gly Ser Phe Gln 
        675                 680                 685             


Gly Arg Pro Val Ala Val Lys Arg Met Leu Ile Asp Phe Cys Asp Ile 
    690                 695                 700                 


Ala Leu Met Glu Ile Lys Leu Leu Thr Glu Ser Asp Asp His Pro Asn 
705                 710                 715                 720 


Val Ile Arg Tyr Tyr Cys Ser Glu Thr Thr Asp Arg Phe Leu Tyr Ile 
                725                 730                 735     


Ala Leu Glu Leu Cys Asn Leu Asn Leu Gln Asp Leu Val Glu Ser Lys 
            740                 745                 750         


Asn Val Ser Asp Glu Asn Leu Lys Leu Gln Lys Glu Tyr Asn Pro Ile 
        755                 760                 765             


Ser Leu Leu Arg Gln Ile Ala Ser Gly Val Ala His Leu His Ser Leu 
    770                 775                 780                 


Lys Ile Ile His Arg Asp Leu Lys Pro Gln Asn Ile Leu Val Ser Thr 
785                 790                 795                 800 


Ser Ser Arg Phe Thr Ala Asp Gln Gln Thr Gly Ala Glu Asn Leu Arg 
                805                 810                 815     


Ile Leu Ile Ser Asp Phe Gly Leu Cys Lys Lys Leu Asp Ser Gly Gln 
            820                 825                 830         


Ser Ser Phe Arg Thr Asn Leu Asn Asn Pro Ser Gly Thr Ser Gly Trp 
        835                 840                 845             


Arg Ala Pro Glu Leu Leu Glu Glu Ser Asn Asn Leu Gln Cys Gln Val 
    850                 855                 860                 


Glu Thr Glu His Ser Ser Ser Arg His Thr Val Val Ser Ser Asp Ser 
865                 870                 875                 880 


Phe Tyr Asp Pro Phe Thr Lys Arg Arg Leu Thr Arg Ser Ile Asp Ile 
                885                 890                 895     


Phe Ser Met Gly Cys Val Phe Tyr Tyr Ile Leu Ser Lys Gly Lys His 
            900                 905                 910         


Pro Phe Gly Asp Lys Tyr Ser Arg Glu Ser Asn Ile Ile Arg Gly Ile 
        915                 920                 925             


Phe Ser Leu Asp Glu Met Lys Cys Leu His Asp Arg Ser Leu Ile Ala 
    930                 935                 940                 


Glu Ala Thr Asp Leu Ile Ser Gln Met Ile Asp His Asp Pro Leu Lys 
945                 950                 955                 960 


Arg Pro Thr Ala Met Lys Val Leu Arg His Pro Leu Phe Trp Pro Lys 
                965                 970                 975     


Ser Lys Lys Leu Glu Phe Leu Leu Lys Val Ser Asp Arg Leu Glu Ile 
            980                 985                 990         


Glu Asn Arg Asp Pro Pro Ser Ala  Leu Leu Met Lys Phe  Asp Ala Gly 
        995                 1000                 1005             


Ser Asp  Phe Val Ile Pro Ser  Gly Asp Trp Thr Val  Lys Phe Asp 
    1010                 1015                 1020             


Lys Thr  Phe Met Asp Asn Leu  Glu Arg Tyr Arg Lys  Tyr His Ser 
    1025                 1030                 1035             


Ser Lys  Leu Met Asp Leu Leu  Arg Ala Leu Arg Asn  Lys Tyr His 
    1040                 1045                 1050             


His Phe  Met Asp Leu Pro Glu  Asp Ile Ala Glu Leu  Met Gly Pro 
    1055                 1060                 1065             


Val Pro  Asp Gly Phe Tyr Asp  Tyr Phe Thr Lys Arg  Phe Pro Asn 
    1070                 1075                 1080             


Leu Leu  Ile Gly Val Tyr Met  Ile Val Lys Glu Asn  Leu Ser Asp 
    1085                 1090                 1095             


Asp Gln  Ile Leu Arg Glu Phe  Leu Tyr Ser 
    1100                 1105             


<210>  297
<211>  921
<212>  DNA
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  297
atgcagttga gcaaggctgc tgagatgtgt tatgagataa caaactctta cttacacata       60

gaccagaaat ctcagataat agcaagtaca caagaagcga tacggttgac aagaaaatac      120

ttactaagtg aaatttttgt acgttggagt ccactgaatg gggaaatatc attctcgtac      180

aacggaggaa aagattgcca ggtattacta ctgttatatc tgagttgctt atgggaatat      240

ttcttcatta aggctcaaaa ttcccaattc gatttcgagt ttcaaagctt ccccatgcaa      300

agacttccaa ctgttttcat tgatcaagaa gaaactttcc ctacattaga gaattttgta      360

ctggaaacct cagagcgata ttgcctttcc ttatacgaat cacaaaggca atctggtgca      420

tcggtcaata tggcagacgc atttagagat tttataaaga tataccctga gaccgaagct      480

atagtgatag gtattagaca cacagaccca tttggtgaag cattaaagcc tattcaaaga      540

acagattcta actggcctga ttttatgagg ttgcaacctc tcttacactg ggacttaacc      600

aatatatgga gtttcttact gtattctaat gagccaattt gtggactata tggtaaaggt      660

ttcacatcaa tcggcggaat taacaactca ttgcctaacc cacacttgag aaaggactcc      720

aataatccag ccttgcattt tgaatgggaa atcattcatg catttggcaa ggacgcagaa      780

ggcgaacgta gttccgctat aaacacgtca cctatttccg tggtggataa ggaaagattc      840

agcaaatacc atgacaatta ctatcctggc tggtatttgg ttgatgacac tttagagaga      900

gcaggcagga tcaagaatta a                                                921


<210>  298
<211>  306
<212>  PRT
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  298

Met Gln Leu Ser Lys Ala Ala Glu Met Cys Tyr Glu Ile Thr Asn Ser 
1               5                   10                  15      


Tyr Leu His Ile Asp Gln Lys Ser Gln Ile Ile Ala Ser Thr Gln Glu 
            20                  25                  30          


Ala Ile Arg Leu Thr Arg Lys Tyr Leu Leu Ser Glu Ile Phe Val Arg 
        35                  40                  45              


Trp Ser Pro Leu Asn Gly Glu Ile Ser Phe Ser Tyr Asn Gly Gly Lys 
    50                  55                  60                  


Asp Cys Gln Val Leu Leu Leu Leu Tyr Leu Ser Cys Leu Trp Glu Tyr 
65                  70                  75                  80  


Phe Phe Ile Lys Ala Gln Asn Ser Gln Phe Asp Phe Glu Phe Gln Ser 
                85                  90                  95      


Phe Pro Met Gln Arg Leu Pro Thr Val Phe Ile Asp Gln Glu Glu Thr 
            100                 105                 110         


Phe Pro Thr Leu Glu Asn Phe Val Leu Glu Thr Ser Glu Arg Tyr Cys 
        115                 120                 125             


Leu Ser Leu Tyr Glu Ser Gln Arg Gln Ser Gly Ala Ser Val Asn Met 
    130                 135                 140                 


Ala Asp Ala Phe Arg Asp Phe Ile Lys Ile Tyr Pro Glu Thr Glu Ala 
145                 150                 155                 160 


Ile Val Ile Gly Ile Arg His Thr Asp Pro Phe Gly Glu Ala Leu Lys 
                165                 170                 175     


Pro Ile Gln Arg Thr Asp Ser Asn Trp Pro Asp Phe Met Arg Leu Gln 
            180                 185                 190         


Pro Leu Leu His Trp Asp Leu Thr Asn Ile Trp Ser Phe Leu Leu Tyr 
        195                 200                 205             


Ser Asn Glu Pro Ile Cys Gly Leu Tyr Gly Lys Gly Phe Thr Ser Ile 
    210                 215                 220                 


Gly Gly Ile Asn Asn Ser Leu Pro Asn Pro His Leu Arg Lys Asp Ser 
225                 230                 235                 240 


Asn Asn Pro Ala Leu His Phe Glu Trp Glu Ile Ile His Ala Phe Gly 
                245                 250                 255     


Lys Asp Ala Glu Gly Glu Arg Ser Ser Ala Ile Asn Thr Ser Pro Ile 
            260                 265                 270         


Ser Val Val Asp Lys Glu Arg Phe Ser Lys Tyr His Asp Asn Tyr Tyr 
        275                 280                 285             


Pro Gly Trp Tyr Leu Val Asp Asp Thr Leu Glu Arg Ala Gly Arg Ile 
    290                 295                 300                 


Lys Asn 
305     


<210>  299
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, I445M variant

<400>  299
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatgtgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  300
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, I445M variant

<400>  300

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Met Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  301
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, M412Q variant

<400>  301
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtcaatacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  302
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, M412Q variant

<400>  302

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Gln Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  303
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L415M variant

<400>  303
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccatgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  304
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, L415M variant

<400>  304

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Met Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  305
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, D115N variant

<400>  305
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc ataattccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  306
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, D115N variant

<400>  306

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asn Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  307
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, A414T variant

<400>  307
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtaca ctttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  308
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, A414T variant

<400>  308

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Thr Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  309
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, A414V variant

<400>  309
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ttttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  310
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, A414V variant

<400>  310

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Val Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  311
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, A414M variant

<400>  311
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtaca tgttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  312
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, A414M variant

<400>  312

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Met Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  313
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, M61W, G378T variant

<400>  313
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

tggtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tactgccttt     1140

aaaatcaaat tggactacgt taagaagcct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  314
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, M61W, G378T variant

<400>  314

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Trp Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Thr Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  315
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, M61W, K389E variant

<400>  315
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

tggtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tggtgccttt     1140

aaaatcaaat tggactacgt taaggaacct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  316
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, M61W, K389E variant

<400>  316

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Trp Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Glu Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  317
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, G378T, K389E variant

<400>  317
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

atgtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tactgccttt     1140

aaaatcaaat tggactacgt taaggaacct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  318
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, G378T, K389E variant

<400>  318

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Thr Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Glu Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  319
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, M61W, G378T, K389E variant

<400>  319
atgaaatgct ccactttctc tttctggttc gtttgtaaga ttatcttctt cttcttttct       60

ttcaacatcc aaacttccat tgccaaccct cgtgagaact tcttgaaatg tttttctcaa      120

tatatcccaa ataacgctac taacttgaag ttagtctata ctcaaaacaa cccattatat      180

tggtctgtct taaactctac cattcacaac ttacgtttca cttctgatac tactccaaaa      240

cctttggtca tcgtcacccc atcccacgtt tctcacatcc aaggtaccat cttgtgttcc      300

aaaaaggttg gtttacaaat ccgtactaga tccggtggtc atgactccga aggtatgtct      360

tacatttccc aagtcccttt cgtcatcgtc gacttaagaa atatgcgttc catcaagatt      420

gatgtccatt cccaaactgc ttgggttgaa gccggtgcca ctttaggtga agtctattac      480

tgggttaacg agaagaatga gaacttatct ttggctgccg gttactgtcc aactgtttgt      540

gctggtggtc atttcggtgg tggtggttac ggtccattaa tgcgtaacta cggtttggct      600

gccgataaca tcattgatgc ccacttagtc aacgttcatg gtaaggtctt ggaccgtaag      660

tctatgggtg aggatttatt ctgggctttg agaggtggtg gtgctgaatc tttcggtatt      720

atcgtcgctt ggaagattag attagttgct gttccaaagt ctactatgtt ctctgttaag      780

aagatcatgg aaattcacga gttggttaaa ttagttaaca aatggcaaaa cattgcctac      840

aagtacgata aagatttgtt attaatgact cactttatca ctagaaacat tactgataac      900

caaggtaaga ataagactgc cattcacact tacttctctt ctgttttctt gggtggtgtt      960

gattccttgg tcgatttgat gaacaagtct tttccagaat taggtattaa gaagaccgat     1020

tgtcgtcaat tatcttggat tgataccatt attttttact ccggtgttgt caactacgac     1080

actgataatt ttaataagga gattttgtta gatagatctg ctggtcaaaa tactgccttt     1140

aaaatcaaat tggactacgt taaggaacct attccagaat ccgtctttgt tcaaattttg     1200

gagaagttat acgaagaaga tattggtgct ggtatgtacg ccttgtatcc atatggtggt     1260

attatggatg aaatttctga atccgccatc cctttccctc atcgtgctgg tatcttatac     1320

gagttgtggt acatctgttc ttgggaaaag caagaagata atgaaaagca tttgaactgg     1380

atccgtaaca tctataactt catgactcca tacgtttcca aaaaccctag attggcttac     1440

ttaaattaca gagacttaga tattggtatt aacgacccta agaacccaaa caattacact     1500

caagctagaa tctggggtga aaagtacttc ggtaagaatt tcgacagatt agttaaggtc     1560

aagactttag ttgacccaaa taacttcttc agaaacgaac aatctatccc accattgcct     1620

agacatagac actag                                                      1635


<210>  320
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CBDA Synthase, M61W, G378T, K389E variant

<400>  320

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Trp Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Thr Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Glu Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  321
<211>  505
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology ui12

<400>  321
tcctacaacg atatcattca cttgaaggaa tacaaaattg ataatgatcc aattgaaaag       60

tacgttaaga acagcggcaa taatttgggg atttgtttct acaaagaata aaaattcatg      120

ttcgacatat agatagcagg gtaatgtacg tgtatatttt aatgtaataa agaggcctta      180

ctagacggta aagttaagaa tatcgagtga acttttcctt aagataaagg taaatatagt      240

cgagtattta tttattattc ttttccacta tacagtattt aaaattctgt aagaaattga      300

ttctacatac ataagacaaa cgaacaggtc agagagaatc agatttttgg ttagcaagaa      360

tacattttgg agaagaaaga cattaactcc accttactgt atcatcttat ttgctttttc      420

actccttcct aatatttttt ttattttatt ttgaatttct tcctatttct gatgcattga      480

acagatcgta atctgtaagt aaata                                            505


<210>  322
<211>  476
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Flanking homology di12

<400>  322
aaatcttggc tccgttgtgt acaaaacttc ttaatgaata tatatatatt tttcccttat       60

tttatctttt tttttcgaat tttttatgta aacattctta tactggaaca atagatggct      120

aatgagtccc tataatttcg attttagatg ttaacgcttc atttcttttc atataaaaga      180

ctacctgcca aatgtatttt ctcctgagta agtgacatac aaaaacccgt ccttatcctt      240

gtgttcttga tatatggcag acatcaacgc cgcagtaggt ggcaaagtat cattgacaaa      300

aatgaagatg gccttctcag ggggtagcat aattctcttt cttataacat aaacaaattg      360

ccctacggta aggtcagcag gaactagata tttacgctta tcaatctctg gaatatctga      420

cttttcagct ttttcgcaaa tcacaggtat cctattcttg aacctgtcag caatcc          476


<210>  323
<211>  1030
<212>  DNA
<213>  Unknown

<220>  
<223>  Saccharomyces sp.

<400>  323
gttaaccatt ctggttcact tgccgtcgta tgttgcggac cacctatttt cgtcgacacc       60

gctagaaatc aaactgccaa agctgttatc agaaacccat caagaatgat tgaatacttg      120

gaggaatacc aagcctggtg aacaattttt catatttaag taaacactca atgtataata      180

tcctctaact gttgtaattt cattaacgta aatggtttgc gcctttttta ggggaccctt      240

gttgattcat tctaactact gaggcataag ttgtttcaaa taacactttt tcagaaaaat      300

aatcgtatta aaaagcagaa aaatcatacg taagatgaca gaagcttcat atttagtaac      360

tctgaattgt ataacacacc aattgccgat agaatatgaa ccaatcgatc ttcagcgttc      420

atgtacttaa tttaactacc tgtattttct tataaagata aaattggtgt ataatgtaag      480

ggccaagaga aaaaggaatc ccgcatccca agcaacttct agtggactat ttcttcaaaa      540

aaataactga ataaacacct atataatgtt cagaggttat actttagtgt tttagaatgc      600

agtaccaaaa gtaatatatt gaattaataa ctatatgatg tgtagctaag aattaaatag      660

taaacgtctt ctgaaacctt ttaagaggta attattggta ttccaaagtc atatgtggag      720

gtaagggaga cacaaaatta tctggaatga cagcgtgctg acacatataa agttccgtaa      780

cttcaaatgc cttcattatt caacatagga aaagtgaaat gtgtgcctct aaaatatacg      840

gaacatcgtc gaactaaaaa aatccattaa gcaaagttag aaacagcatg cactacaaga      900

catttggttc atcatgaaga atgctcaatt gaaccatcaa tcactttctc ttgttcgatg      960

ttagcattat cctcactatc agttgaatcc tcaatgcttt cggtttcagt cctcgcatct     1020

tcctgaactt                                                            1030


