                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
       Damask, Amy
       Paulding, Charles
       Baras, Aris
       Abecasis, Goncalo
 
<120>  Genome-Based Methods For Reducing Cardiovascular Risk

<130>  189238.01702 (3225) (10566WO01)

<150>  62/849,670
<151>  2019-05-17

<150>  62/933,181
<151>  2019-11-08

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  3731
<212>  DNA
<213>  homo sapien

<400>  1
gtccgatggg gctctggtgg cgtgatctgc gcgccccagg cgtcaagcac ccacacccta       60

gaaggtttcc gcagcgacgt cgaggcgctc atggttgcag gcgggcgccg ccgttcagtt      120

cagggtctga gcctggagga gtgagccagg cagtgagact ggctcgggcg ggccgggacg      180

cgtcgttgca gcagcggctc ccagctccca gccaggattc cgcgcgcccc ttcacgcgcc      240

ctgctcctga acttcagctc ctgcacagtc ctccccaccg caaggctcaa ggcgccgccg      300

gcgtggaccg cgcacggcct ctaggtctcc tcgccaggac agcaacctct cccctggccc      360

tcatgggcac cgtcagctcc aggcggtcct ggtggccgct gccactgctg ctgctgctgc      420

tgctgctcct gggtcccgcg ggcgcccgtg cgcaggagga cgaggacggc gactacgagg      480

agctggtgct agccttgcgt tccgaggagg acggcctggc cgaagcaccc gagcacggaa      540

ccacagccac cttccaccgc tgcgccaagg atccgtggag gttgcctggc acctacgtgg      600

tggtgctgaa ggaggagacc cacctctcgc agtcagagcg cactgcccgc cgcctgcagg      660

cccaggctgc ccgccgggga tacctcacca agatcctgca tgtcttccat ggccttcttc      720

ctggcttcct ggtgaagatg agtggcgacc tgctggagct ggccttgaag ttgccccatg      780

tcgactacat cgaggaggac tcctctgtct ttgcccagag catcccgtgg aacctggagc      840

ggattacccc tccacggtac cgggcggatg aataccagcc ccccgacgga ggcagcctgg      900

tggaggtgta tctcctagac accagcatac agagtgacca ccgggaaatc gagggcaggg      960

tcatggtcac cgacttcgag aatgtgcccg aggaggacgg gacccgcttc cacagacagg     1020

ccagcaagtg tgacagtcat ggcacccacc tggcaggggt ggtcagcggc cgggatgccg     1080

gcgtggccaa gggtgccagc atgcgcagcc tgcgcgtgct caactgccaa gggaagggca     1140

cggttagcgg caccctcata ggcctggagt ttattcggaa aagccagctg gtccagcctg     1200

tggggccact ggtggtgctg ctgcccctgg cgggtgggta cagccgcgtc ctcaacgccg     1260

cctgccagcg cctggcgagg gctggggtcg tgctggtcac cgctgccggc aacttccggg     1320

acgatgcctg cctctactcc ccagcctcag ctcccgaggt catcacagtt ggggccacca     1380

atgcccaaga ccagccggtg accctgggga ctttggggac caactttggc cgctgtgtgg     1440

acctctttgc cccaggggag gacatcattg gtgcctccag cgactgcagc acctgctttg     1500

tgtcacagag tgggacatca caggctgctg cccacgtggc tggcattgca gccatgatgc     1560

tgtctgccga gccggagctc accctggccg agttgaggca gagactgatc cacttctctg     1620

ccaaagatgt catcaatgag gcctggttcc ctgaggacca gcgggtactg acccccaacc     1680

tggtggccgc cctgcccccc agcacccatg gggcaggttg gcagctgttt tgcaggactg     1740

tatggtcagc acactcgggg cctacacgga tggccacagc cgtcgcccgc tgcgccccag     1800

atgaggagct gctgagctgc tccagtttct ccaggagtgg gaagcggcgg ggcgagcgca     1860

tggaggccca agggggcaag ctggtctgcc gggcccacaa cgcttttggg ggtgagggtg     1920

tctacgccat tgccaggtgc tgcctgctac cccaggccaa ctgcagcgtc cacacagctc     1980

caccagctga ggccagcatg gggacccgtg tccactgcca ccaacagggc cacgtcctca     2040

caggctgcag ctcccactgg gaggtggagg accttggcac ccacaagccg cctgtgctga     2100

ggccacgagg tcagcccaac cagtgcgtgg gccacaggga ggccagcatc cacgcttcct     2160

gctgccatgc cccaggtctg gaatgcaaag tcaaggagca tggaatcccg gcccctcagg     2220

agcaggtgac cgtggcctgc gaggagggct ggaccctgac tggctgcagt gccctccctg     2280

ggacctccca cgtcctgggg gcctacgccg tagacaacac gtgtgtagtc aggagccggg     2340

acgtcagcac tacaggcagc accagcgaag gggccgtgac agccgttgcc atctgctgcc     2400

ggagccggca cctggcgcag gcctcccagg agctccagtg acagccccat cccaggatgg     2460

gtgtctgggg agggtcaagg gctggggctg agctttaaaa tggttccgac ttgtccctct     2520

ctcagccctc catggcctgg cacgagggga tggggatgct tccgcctttc cggggctgct     2580

ggcctggccc ttgagtgggg cagcctcctt gcctggaact cactcactct gggtgcctcc     2640

tccccaggtg gaggtgccag gaagctccct ccctcactgt ggggcatttc accattcaaa     2700

caggtcgagc tgtgctcggg tgctgccagc tgctcccaat gtgccgatgt ccgtgggcag     2760

aatgactttt attgagctct tgttccgtgc caggcattca atcctcaggt ctccaccaag     2820

gaggcaggat tcttcccatg gataggggag ggggcggtag gggctgcagg gacaaacatc     2880

gttggggggt gagtgtgaaa ggtgctgatg gccctcatct ccagctaact gtggagaagc     2940

ccctgggggc tccctgatta atggaggctt agctttctgg atggcatcta gccagaggct     3000

ggagacaggt gcgcccctgg tggtcacagg ctgtgccttg gtttcctgag ccacctttac     3060

tctgctctat gccaggctgt gctagcaaca cccaaaggtg gcctgcgggg agccatcacc     3120

taggactgac tcggcagtgt gcagtggtgc atgcactgtc tcagccaacc cgctccacta     3180

cccggcaggg tacacattcg cacccctact tcacagagga agaaacctgg aaccagaggg     3240

ggcgtgcctg ccaagctcac acagcaggaa ctgagccaga aacgcagatt gggctggctc     3300

tgaagccaag cctcttctta cttcacccgg ctgggctcct catttttacg ggtaacagtg     3360

aggctgggaa ggggaacaca gaccaggaag ctcggtgagt gatggcagaa cgatgcctgc     3420

aggcatggaa ctttttccgt tatcacccag gcctgattca ctggcctggc ggagatgctt     3480

ctaaggcatg gtcgggggag agggccaaca actgtccctc cttgagcacc agccccaccc     3540

aagcaagcag acatttatct tttgggtctg tcctctctgt tgccttttta cagccaactt     3600

ttctagacct gttttgcttt tgtaacttga agatatttat tctgggtttt gtagcatttt     3660

tattaatatg gtgacttttt aaaataaaaa caaacaaacg ttgtcctaac aaaaaaaaaa     3720

aaaaaaaaaa a                                                          3731


<210>  2
<211>  635
<212>  PRT
<213>  homo sapien

<400>  2

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys 
625                 630                 635 


