                         SEQUENCE LISTING

<110>  NURIX THERAPEUTICS, INC.
 
<120>  CYANO CYCLOBUTYL COMPOUNDS FOR CBL-B INHIBITION AND USES THEREOF

<130>  121843.00049

<140>  PCT/US2020/033274
<141>  2020-05-15

<150>  US 62/849,722
<151>  2019-05-17

<150>  US 62/880,437
<151>  2019-07-30

<150>  US 62/888,845
<151>  2019-08-19

<150>  US 62/888,870
<151>  2019-08-19

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  392
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Cbl-b amino acid residues 36-427

<400>  1

Pro Lys Gln Ala Ala Ala Asp Arg Arg Thr Val Glu Lys Thr Trp Lys 
1               5                   10                  15      


Leu Met Asp Lys Val Val Arg Leu Cys Gln Asn Pro Lys Leu Gln Leu 
            20                  25                  30          


Lys Asn Ser Pro Pro Tyr Ile Leu Asp Ile Leu Pro Asp Thr Tyr Gln 
        35                  40                  45              


His Leu Arg Leu Ile Leu Ser Lys Tyr Asp Asp Asn Gln Lys Leu Ala 
    50                  55                  60                  


Gln Leu Ser Glu Asn Glu Tyr Phe Lys Ile Tyr Ile Asp Ser Leu Met 
65                  70                  75                  80  


Lys Lys Ser Lys Arg Ala Ile Arg Leu Phe Lys Glu Gly Lys Glu Arg 
                85                  90                  95      


Met Tyr Glu Glu Gln Ser Gln Asp Arg Arg Asn Leu Thr Lys Leu Ser 
            100                 105                 110         


Leu Ile Phe Ser His Met Leu Ala Glu Ile Lys Ala Ile Phe Pro Asn 
        115                 120                 125             


Gly Gln Phe Gln Gly Asp Asn Phe Arg Ile Thr Lys Ala Asp Ala Ala 
    130                 135                 140                 


Glu Phe Trp Arg Lys Phe Phe Gly Asp Lys Thr Ile Val Pro Trp Lys 
145                 150                 155                 160 


Val Phe Arg Gln Cys Leu His Glu Val His Gln Ile Ser Ser Gly Leu 
                165                 170                 175     


Glu Ala Met Ala Leu Lys Ser Thr Ile Asp Leu Thr Cys Asn Asp Tyr 
            180                 185                 190         


Ile Ser Val Phe Glu Phe Asp Ile Phe Thr Arg Leu Phe Gln Pro Trp 
        195                 200                 205             


Gly Ser Ile Leu Arg Asn Trp Asn Phe Leu Ala Val Thr His Pro Gly 
    210                 215                 220                 


Tyr Met Ala Phe Leu Thr Tyr Asp Glu Val Lys Ala Arg Leu Gln Lys 
225                 230                 235                 240 


Tyr Ser Thr Lys Pro Gly Ser Tyr Ile Phe Arg Leu Ser Cys Thr Arg 
                245                 250                 255     


Leu Gly Gln Trp Ala Ile Gly Tyr Val Thr Gly Asp Gly Asn Ile Leu 
            260                 265                 270         


Gln Thr Ile Pro His Asn Lys Pro Leu Phe Gln Ala Leu Ile Asp Gly 
        275                 280                 285             


Ser Arg Glu Gly Phe Tyr Leu Tyr Pro Asp Gly Arg Ser Tyr Asn Pro 
    290                 295                 300                 


Asp Leu Thr Gly Leu Cys Glu Pro Thr Pro His Asp His Ile Lys Val 
305                 310                 315                 320 


Thr Gln Glu Gln Tyr Glu Leu Tyr Cys Glu Met Gly Ser Thr Phe Gln 
                325                 330                 335     


Leu Cys Lys Ile Cys Ala Glu Asn Asp Lys Asp Val Lys Ile Glu Pro 
            340                 345                 350         


Cys Gly His Leu Met Cys Thr Ser Cys Leu Thr Ala Trp Gln Glu Ser 
        355                 360                 365             


Asp Gly Gln Gly Cys Pro Phe Cys Arg Cys Glu Ile Lys Gly Thr Glu 
    370                 375                 380                 


Pro Ile Ile Val Asp Pro Phe Asp 
385                 390         


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CTL epitope of residues 49-57 of E7

<400>  2

Arg Ala His Tyr Asn Ile Val Thr Phe 
1               5                   


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: amino acid sequence of a Th epitope known as PADRE


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-alanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is L-cyclohexylalanine

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  D-alanine

<400>  3

Ala Lys Xaa Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10              


