                         SEQUENCE LISTING

<110>  Massachusetts Institute of Technology
 
<120>  ENGINEERED POST-POLY A SIGNAL RNA AND USES THEREOF

<130>  M0656.70470WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/849,424
<151>  2019-05-17

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
gattcgtcag tagggttgta aaggtttttc ttttcctgag aaaacaacct tttgttttct       60

caggttttgc tttttggcct ttccctagct ttaaaaaaaa aaaagcaaaa c               111


<210>  2
<211>  2615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  2
actttaagta gaaggggatg tccaagtaat tttggttttc taactgttga atcataagct       60

tgacctgccc ccagaggctt tttggatgtt tttatctgtg ttttgccatc tctttacact      120

cctcgacatt cagtttacct taatcttcac atttttacac cttgggaagt ggcaagcatc      180

gctgggttta agataaagga gtcacaaaaa ctaatcaaaa taaaatttgc attatgacaa      240

cttttaatac actttagcat tttatttgat tggttttttt tttttttgct tttagattta      300

atacatatac ggacgattgc acagacttgg ggacctgatg agtccgtgag gacgaaacga      360

gtaagctcgt cttaaaacag ctctggggtt gtacccaccc cagaggccca cgtggcggct      420

agtactccgg tattgcggta cccttgtacg cctgttttat actcccttcc cgtaacttag      480

acgcacaaaa ccaagttcaa tagaaggggg tacaaaccag taccaccacg aacaagcact      540

tctgtttccc cggtgatgtc gtatagactg cttgcgtggt tgaaagcgac ggatccgtta      600

tccgcttatg tacttcgaga agcccagtac cacctcggaa tcttcgatgc gttgcgctca      660

gcactcaacc ccagagtgta gcttaggctg atgagtctgg acatccctca ccggtgacgg      720

tggtccaggc tgcgttggcg gcctacctat ggctaacgcc atgggacgct agttgtgaac      780

aaggtgtgaa gagcctattg agctacataa gaatcctccg gcccctgaat gcggctaatc      840

ccaacctcgg agcaggtggt cacaaaccag tgattggcct gtcgtaacgc gcaagtccgt      900

ggcggaaccg actactttgg gtgtccgtgt ttccttttat tttattgtgg ctgcttatgg      960

tgacaatcac agattgttat cataaagcga aggtgccacc atggtgagcg agctgattaa     1020

ggagaacatg cacatgaagc tgtacatgga gggcaccgtg aacaaccacc acttcaagtg     1080

cacatccgag ggcgaaggca agccctacga gggcacccag accatgagaa tcaaggcggt     1140

cgagggcggc cctctcccct tcgccttcga catcctggct accagcttca tgtacggcag     1200

caaaaccttc atcaaccaca cccagggcat ccccgacttc tttaagcagt ccttccccga     1260

gggcttcaca tgggagagag tcaccacata cgaagatggg ggcgtgctga ccgctaccca     1320

ggacaccagc ctccaggacg gctgcctcat ctacaacgtc aagatcagag gggtgaactt     1380

cccatccaac ggccctgtga tgcagaagaa aacactcggc tgggaggcct ccaccgagac     1440

actgtacccc gctgacggcg gcctggaagg cagagccgac atggccctga agctcgtggg     1500

cgggggccac ctgatctgca accttaagac cacatacaga tccaagaaac ccgctaagaa     1560

cctcaagatg cccggcgtct actatgtgga caggagactg gaaagaatca aggaggccga     1620

caaagagaca tacgtcgagc agcacgaggt ggctgtggcc agatactgcg acctccctag     1680

caaactgggg cacaaactta attgagctta atcaacctct ggattacaaa atttgtgaaa     1740

gattgactgg tattcttaac tatgttgctc cttttacgct atgtggatac gctgctttaa     1800

tgcctttgta tcatgctatt gcttcccgta tggctttcat tttctcctcc ttgtataaat     1860

cctggttgct gtctctttat gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt     1920

gcactgtgtt tgctgacgca acccccactg gttggggcat tgccaccacc tgtcagctcc     1980

tttccgggac tttcgctttc cccctcccta ttgccacggc ggaactcatc gccgcctgcc     2040

ttgcccgctg ctggacaggg gctcggctgt tgggcactga caattccgtg gtgttgtcgg     2100

ggaagctgac gtcctttcca tggctgctcg cctgtgttgc cacctggatt ctgcgcggga     2160

cgtccttctg ctacgtccct tcggccctca atccagcgga ccttccttcc cgcggcctgc     2220

tgccggctct gcggcctctt ccgcgtcttc gccttcgccc tcagacgagt cggatctccc     2280

tttgggccgc ctccccgcct gtttcgcctc ggcgtccggt ccgtgttgct tggtcttcac     2340

ctgtgcagac ttgcgaacca tggattcaat tgttgttgtt aaccggtgat tcgtcagtag     2400

ggttgtaaag gtttttcttt tcctgagaaa acaacctttt gttttctcag gttttgcttt     2460

ttggcctttc cctagcttta aaaaaaaaaa agcaaaactc accgaggcag ttccatagga     2520

tggcaagatc ctggtattgg tctgcgaggc cggcatggtc ccagcctcct cgctggcgcc     2580

ggctgggcaa catgcttcgg catggcgaat gggac                                2615


<210>  3
<211>  88
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
ttaaaacagc tctggggttg tacccacccc agaggcccac gtggcggcta gtactccggt       60

attgcggtac ccttgtacgc ctgtttta                                          88


<210>  4
<211>  497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  4
agttcaatag aagggggtac aaaccagtac caccacgaac aagcacttct gtttccccgg       60

tgatgtcgta tagactgctt gcgtggttga aagcgacgga tccgttatcc gcttatgtac      120

ttcgagaagc ccagtaccac ctcggaatct tcgatgcgtt gcgctcagca ctcaacccca      180

gagtgtagct taggctgatg agtctggaca tccctcaccg gtgacggtgg tccaggctgc      240

gttggcggcc tacctatggc taacgccatg ggacgctagt tgtgaacaag gtgtgaagag      300

cctattgagc tacataagaa tcctccggcc cctgaatgcg gctaatccca acctcggagc      360

aggtggtcac aaaccagtga ttggcctgtc gtaacgcgca agtccgtggc ggaaccgact      420

actttgggtg tccgtgtttc cttttatttt attgtggctg cttatggtga caatcacaga      480

ttgttatcat aaagcga                                                     497


<210>  5
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
ggccggcatg gtcccagcct cctcgctggc gccggctggg caacatgctt cggcatggcg       60

aatgggac                                                                68


<210>  6
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  6
ggggacctga tgagtccgtg aggacgaaac gagtaagctc gtc                         43


<210>  7
<211>  658
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  7
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaagctga cgtcctttcc atggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgcc tgtttcgcct      600

cggcgtccgg tccgtgttgc ttggtcttca cctgtgcaga cttgcgaacc atggattc        658


<210>  8
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  8
taaagcttga ggtgagtatg tgctcgcttc ggcagcacat atactatgtt gaatgaggct       60

tcagtacttt acagaatcgt tgcctgcaca tcttggaaac acttgctggg attacttctt      120

caggttaacc caacagaagg ctcgagtgct gttgacagtg agcgccgctt gaagttttta      180

attaaatagt gaagccacag atgtatttaa ttaaagactt caagcggtgc ctactgcctc      240

ggagaattca aggggctact ttaggagcaa ttatcttgtt tactaaaact gaataccttg      300

ctatctcttt gatacatttt tacaaagctg aattaaaatg gtataaatta aatcactttt      360

ttcaattgtt tccttttttt tcctcagggt acccagcttt cttgtacaaa gtggtacgcg      420


<210>  9
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (80)..(100)
<223>  may be absent

<400>  9
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                            100


<210>  10
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  10
aaaaaaaaaa aaaa                                                         14


<210>  11
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  11
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                            100


<210>  12
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  12
ctcaccgagg acactggggg caagggggac ctgatgagct tttttgcgaa acgagtaagc       60

tcgtc                                                                   65


<210>  13
<211>  156
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (58)..(79)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (98)..(119)
<223>  n is a, c, g, t or u

<400>  13
ucgacttguu aacccaacag aaggcucgag aagguauauu gcuguugaca gugagcgnnn       60

nnnnnnnnnn nnnnnnnnna gugaagccac agauguannn nnnnnnnnnn nnnnnnnnnu      120

gccuacugcc ucggacuuca aggggcuaga auugga                                156


<210>  14
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  14
aaaaaaaaaa                                                              10


<210>  15
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  15
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120


