               SEQUENCE LISTING

<110> OZDARENDELI AYKUT

<120> UNIVERSAL CRIMEAN CONGO HAEMORRHAGIC FEVER VIRUS (CCHFV) VACCINE

<130> P20-0703

<150> TR2019/07557
<151> 2019-05-20

<160> 14

<170> BiSSAP 1.3.6

<210> 1
<211> 5067
<212> DNA
<213> Artificial Sequence


<220> 
<223> nucleic acid sequence encoding group V of Crimean Congo
      Haemorrhagic Fever Virus BGCA Glycoprotein

<400> 1
atgccgacca acattatgca taccctgctg gtgtgcttta ttctgtatct gcagctgctg       60

ggcctgggcg gcgcgcatgg ccagagcaac gcgaccgaac ataacggcac caacaacacc      120

accgcgccgg gcaccagcca gagcccgaaa ccgccggtga gcaccacccc gccgcatgcg      180

ccggaaagca gcaccattaa accgaccacc ccgaccagcg aaaccgaagg cagcggcgaa      240

accaccccga ccccgaacac cacccagggc ccgagcccgc cggaaaccac cccggaacgc      300

ccggcgacca ccgcgaccag caccagcagc accgataaca ccaacagcac cacccagatg      360

accgataaca ccccgaccag caccgtgagc accagcccga gcagcagccc gagcaccccg      420

agcaccccgc agggcattca tcatccggcg cgcagcctgc tgagcgtgag cagcccgaaa      480

accgcgacca ccccgacccc gaccagcccg ggcgaaatga gcagcgaaac cagcagccag      540

catagcgcga tgagccgcac cccgaccccg cataccgcga cccaggtgag caccgaaaac      600

gcgaaccata gcaccccgcg ccagagcgaa agcagcgcgc agccgaccac caccagcccg      660

atgaccagcc cggcgcagag cattctgctg atgagcgcgg cgccgaccgc gattcagaac      720

attcatccga gcccgaccaa ccgcagcaaa cgcaacctgg aaatggaaat tattctgacc      780

ctgagccagg gcctgaaaaa atattatggc aaaattctga aactgctgca tctgaccctg      840

gaagaagata ccgaaggcct gctggaatgg tgcaaacgca acctgggcag caactgcgat      900

gatgattttt ttcagaaacg cattgaagaa ttttttatga ccggcgaagg ctattttaac      960

gaagtgctgc agtttaaaac cctgagcacc ctgagcccga ccgaaccgag ccatgcgcgc     1020

ctgccgaccg cggaaccgtt taaaagctat tttgcgaaag gctttctgag cattgatagc     1080

ggctatttta gcgcgaaatg ctatccgcgc agcagcacca gcggcctgca gctgattaac     1140

gtgacccagc atccggcgcg cattgcggaa accccgggcc cgaaaaccac cagcctgaaa     1200

accattaact gcattaacct gcgcgcgagc gtgtttaaag aacatcgcga aattgaaatt     1260

aacgtgctgc tgccgcagat tgcggtgaac ctgagcaact gccatgtggt gattaacagc     1320

catgtgtgcg attatagcct ggataccgat ggcccggtgc gcctgccgcg catttatcat     1380

gaaggcacct ttattccggg cacctataaa attgtgattg ataaaaaaaa caaactgaac     1440

gatcgctgca ccctggtgac caactgcgtg attaaaggcc gcgaagtgcg caaaggccag     1500

agcgtgctgc gccagtataa aaccgaaatt aaaattggca aagcgagcac cggcagccgc     1560

aaactgctga gcgaagaacc gggcgatgat tgcattagcc gcacccagct gctgcgcacc     1620

gaaaccgcgg aaattcatga tgataactat ggcggcccgg gcgataaaat taccatttgc     1680

aacggcagca ccattgtgga tcagcgcctg ggcagcgaac tgggctgcta taccattaac     1740

cgcgtgaaaa gctttaaact gtgcgaaaac agcgcgaccg gcaaaacctg cgaaattgat     1800

agcaccccgg tgaaatgccg ccagggcttt tgcctgaaaa ttacccagga aggccgcggc     1860

catgtgaaac tgagccgcgg cagcgaagtg gtgctggatg cgtgcgatag cagctgcgaa     1920

gtgatgattc cgaaaggcac cggcgatatt ctggtggatt gcagcggcgg ccagcagcat     1980

tttctgaaag ataacctgat tgatctgggc tgcccgcata ttccgctgct gggcaaaatg     2040

gcgatttata tttgccgcat gagcaaccat ccgcgcacca ccatggcgtt tctgttttgg     2100

tttagctttg gctatgtgat tacctgcatt ttttgcaaag cgctgtttta tagcctgatt     2160

attattggca ccctgggcaa aaaaattaaa cagtatcgcg aactgaaacc gcagacctgc     2220

accatttgcg aaaccgcgcc ggtgaacgcg attgatgcgg aaatgcatga tctgaactgc     2280

agctataaca tttgcccgta ttgcgcgagc cgcctgacca gcgatggcct ggcgcgccat     2340

gtgacccagt gcccgaaacg caaagaaaaa gtggaagaaa ccgaactgta tctgaacctg     2400

gaacgcattc cgtggattgt gcgcaaactg ctgcaggtga gcgaaagcac cggcgtggcg     2460

ctgaaacgca gcagctggct gattgtgctg ctggtgctgc tgaccgtgag cctgagcccg     2520

gtgcagagcg cgccggtggg ccatggcaaa accattgaaa cctatcagac ccgcgaaggc     2580

tttaccagca tttgcctgtt tatgctgggc agcattctgt ttattgtgag ctgcctggtg     2640

aaaggcctgg tggatagcgt gagcgatagc ttttttccgg gcctgagcgt gtgcaaaacc     2700

tgcagcattg gcagcattaa cggctttgaa attgaaagcc ataaatgcta ttgcagcctg     2760

ttttgctgcc cgtattgccg ccattgcagc gcggatcgcg aaattcatca gctgcatctg     2820

agcatttgca aaaaacgcaa aaccggcagc aacgtgatgc tggcggtgtg caaacgcatg     2880

tgctttcgcg cgaccattga agcgagccgc cgcgcgctgc tgattcgcag cattattaac     2940

accacctttg tgatttgcat tctgaccctg accatttgcg tggtgagcac cagcgcggtg     3000

gaaatggaaa acctgccggc gggcacctgg gaacgcgaag aagatctgac caacttttgc     3060

catcaggaat gccaggtgac cgaaaccgaa tgcctgtgcc cgtatgaagc gctggtgctg     3120

cgcaaaccgc tgtttctgga tagcattgtg aaaggcatga aaaacctgct gaacagcacc     3180

agcctggaaa ccagcctgag cattgaagcg ccgtggggcg cgattaacgt gcagagcacc     3240

tttaaaccga ccgtgagcac cgcgaacatt gcgctgagct ggagcagcgt ggaacatcgc     3300

ggcaacaaaa ttctggtgac cggccgcagc gaaagcatta tgaaactgga agaacgcacc     3360

ggcgtgagct gggatctggg cgtggaagat gcgagcgaaa gcaaactgct gaccgtgagc     3420

attatggatc tgagccagat gtatagcccg gtgtttgaat atctgagcgg cgatcgccag     3480

gtggaagaat ggccgaaagc gacctgcacc ggcgattgcc cggaacgctg cggctgcacc     3540

agcagcacct gcctgcataa agaatggccg catagccgca actggcgctg caacccgacc     3600

tggtgctggg gcgtgggcac cggctgcacc tgctgcggcg tggatgtgaa agatctgttt     3660

accgatcata tgtttgtgaa atggaaagtg gaatatatta aaaccgaagc gattgtgtgc     3720

gtggaactga ccagccagga acgccagtgc agcctgattg aagcgggcac ccgctttaac     3780

ctgggcccgg tgaccattac cctgagcgaa ccgcgcaaca ttcagcagaa actgccgccg     3840

gaaattatta ccctgcatcc gaaaattgaa gaaggctttt ttgatctgat gcatgtgcag     3900

aaagtgctga gcgcgagcac cgtgtgcaaa ctgcagagct gcacccatgg cattccgggc     3960

gatctgcagg tgtatcatat tggcaacctg ctgaaaggcg atcgcgtgaa cggccatctg     4020

attcataaaa ttgaaccgca ttttaacacc agctggatga gctgggatgg ctgcgatctg     4080

gattattatt gcaacatggg cgattggccg agctgcacct ataccggcgt gacccagcat     4140

aaccatgcgg cgtttgtgaa cctgctgaac attgaaaccg attataccaa aacctttcat     4200

tttcatagca aacgcgtgac cgcgcatggc gataccccgc agctggatct gaaagcgcgc     4260

ccgacctatg gcgcgggcga aattaccgtg ctggtggaag tggcggatat ggaactgcat     4320

accaaaaaag tggaaattag cggcctgaaa tttgcgagcc tggcgtgcac cggctgctat     4380

gcgtgcagca gcggcattag ctgcaaagtg cgcattcatg tggatgaacc ggatgaactg     4440

accgtgcatg tgaaaagcag cgatccggat gtggtggcgg cgagcaccag cctgatggcg     4500

cgcaaactgg aatttggcac cgatagcacc tttaaagcgt ttagcgcgat gccgaaaacc     4560

agcctgtgct tttatattgt ggaacgcgaa tattgcaaaa gctgcagcga agatgatacc     4620

cagaaatgcg tggataccaa actggaacag ccgcagagca ttctgattga acataaaggc     4680

accattattg gcaaacagaa cgatacctgc accgcgaaag cgagctgctg gctggaaagc     4740

gtgaaaagct ttttttatgg cctgaaaaac atgctgggca gcgtgtttgg caactttttt     4800

attggcattc tgctgtttct ggcgccgttt gtgctgctgg tgctgttttt tatgtttggc     4860

tggaaaattc tgttttgctt taaatgctgc cgccgcaccc gcggcctgtt taaatatcgc     4920

catctgaaag atgatgaaga aaccggctat cgccgcatta ttgaacgcct gaacaacaaa     4980

aaaggcaaaa accgcctgct ggatggcgaa cgcctggcgg atcgcaaaat tgcggaactg     5040

tttagcacca aaacccatat tggctaa                                         5067


<210> 2
<211> 1688
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence encoding group V of Crimean Congo
      Haemorrhagic Fever Virus BGCA Glycoprotein

<400> 2
Met Pro Thr Asn Ile Met His Thr Leu Leu Val Cys Phe Ile Leu Tyr 
1               5                   10                  15      
Leu Gln Leu Leu Gly Leu Gly Gly Ala His Gly Gln Ser Asn Ala Thr 
            20                  25                  30          
Glu His Asn Gly Thr Asn Asn Thr Thr Ala Pro Gly Thr Ser Gln Ser 
        35                  40                  45              
Pro Lys Pro Pro Val Ser Thr Thr Pro Pro His Ala Pro Glu Ser Ser 
    50                  55                  60                  
Thr Ile Lys Pro Thr Thr Pro Thr Ser Glu Thr Glu Gly Ser Gly Glu 
65                  70                  75                  80  
Thr Thr Pro Thr Pro Asn Thr Thr Gln Gly Pro Ser Pro Pro Glu Thr 
                85                  90                  95      
Thr Pro Glu Arg Pro Ala Thr Thr Ala Thr Ser Thr Ser Ser Thr Asp 
            100                 105                 110         
Asn Thr Asn Ser Thr Thr Gln Met Thr Asp Asn Thr Pro Thr Ser Thr 
        115                 120                 125             
Val Ser Thr Ser Pro Ser Ser Ser Pro Ser Thr Pro Ser Thr Pro Gln 
    130                 135                 140                 
Gly Ile His His Pro Ala Arg Ser Leu Leu Ser Val Ser Ser Pro Lys 
145                 150                 155                 160 
Thr Ala Thr Thr Pro Thr Pro Thr Ser Pro Gly Glu Met Ser Ser Glu 
                165                 170                 175     
Thr Ser Ser Gln His Ser Ala Met Ser Arg Thr Pro Thr Pro His Thr 
            180                 185                 190         
Ala Thr Gln Val Ser Thr Glu Asn Ala Asn His Ser Thr Pro Arg Gln 
        195                 200                 205             
Ser Glu Ser Ser Ala Gln Pro Thr Thr Thr Ser Pro Met Thr Ser Pro 
    210                 215                 220                 
Ala Gln Ser Ile Leu Leu Met Ser Ala Ala Pro Thr Ala Ile Gln Asn 
225                 230                 235                 240 
Ile His Pro Ser Pro Thr Asn Arg Ser Lys Arg Asn Leu Glu Met Glu 
                245                 250                 255     
Ile Ile Leu Thr Leu Ser Gln Gly Leu Lys Lys Tyr Tyr Gly Lys Ile 
            260                 265                 270         
Leu Lys Leu Leu His Leu Thr Leu Glu Glu Asp Thr Glu Gly Leu Leu 
        275                 280                 285             
Glu Trp Cys Lys Arg Asn Leu Gly Ser Asn Cys Asp Asp Asp Phe Phe 
    290                 295                 300                 
Gln Lys Arg Ile Glu Glu Phe Phe Met Thr Gly Glu Gly Tyr Phe Asn 
305                 310                 315                 320 
Glu Val Leu Gln Phe Lys Thr Leu Ser Thr Leu Ser Pro Thr Glu Pro 
                325                 330                 335     
Ser His Ala Arg Leu Pro Thr Ala Glu Pro Phe Lys Ser Tyr Phe Ala 
            340                 345                 350         
Lys Gly Phe Leu Ser Ile Asp Ser Gly Tyr Phe Ser Ala Lys Cys Tyr 
        355                 360                 365             
Pro Arg Ser Ser Thr Ser Gly Leu Gln Leu Ile Asn Val Thr Gln His 
    370                 375                 380                 
Pro Ala Arg Ile Ala Glu Thr Pro Gly Pro Lys Thr Thr Ser Leu Lys 
385                 390                 395                 400 
Thr Ile Asn Cys Ile Asn Leu Arg Ala Ser Val Phe Lys Glu His Arg 
                405                 410                 415     
Glu Ile Glu Ile Asn Val Leu Leu Pro Gln Ile Ala Val Asn Leu Ser 
            420                 425                 430         
Asn Cys His Val Val Ile Asn Ser His Val Cys Asp Tyr Ser Leu Asp 
        435                 440                 445             
Thr Asp Gly Pro Val Arg Leu Pro Arg Ile Tyr His Glu Gly Thr Phe 
    450                 455                 460                 
Ile Pro Gly Thr Tyr Lys Ile Val Ile Asp Lys Lys Asn Lys Leu Asn 
465                 470                 475                 480 
Asp Arg Cys Thr Leu Val Thr Asn Cys Val Ile Lys Gly Arg Glu Val 
                485                 490                 495     
Arg Lys Gly Gln Ser Val Leu Arg Gln Tyr Lys Thr Glu Ile Lys Ile 
            500                 505                 510         
Gly Lys Ala Ser Thr Gly Ser Arg Lys Leu Leu Ser Glu Glu Pro Gly 
        515                 520                 525             
Asp Asp Cys Ile Ser Arg Thr Gln Leu Leu Arg Thr Glu Thr Ala Glu 
    530                 535                 540                 
Ile His Asp Asp Asn Tyr Gly Gly Pro Gly Asp Lys Ile Thr Ile Cys 
545                 550                 555                 560 
Asn Gly Ser Thr Ile Val Asp Gln Arg Leu Gly Ser Glu Leu Gly Cys 
                565                 570                 575     
Tyr Thr Ile Asn Arg Val Lys Ser Phe Lys Leu Cys Glu Asn Ser Ala 
            580                 585                 590         
Thr Gly Lys Thr Cys Glu Ile Asp Ser Thr Pro Val Lys Cys Arg Gln 
        595                 600                 605             
Gly Phe Cys Leu Lys Ile Thr Gln Glu Gly Arg Gly His Val Lys Leu 
    610                 615                 620                 
Ser Arg Gly Ser Glu Val Val Leu Asp Ala Cys Asp Ser Ser Cys Glu 
625                 630                 635                 640 
Val Met Ile Pro Lys Gly Thr Gly Asp Ile Leu Val Asp Cys Ser Gly 
                645                 650                 655     
Gly Gln Gln His Phe Leu Lys Asp Asn Leu Ile Asp Leu Gly Cys Pro 
            660                 665                 670         
His Ile Pro Leu Leu Gly Lys Met Ala Ile Tyr Ile Cys Arg Met Ser 
        675                 680                 685             
Asn His Pro Arg Thr Thr Met Ala Phe Leu Phe Trp Phe Ser Phe Gly 
    690                 695                 700                 
Tyr Val Ile Thr Cys Ile Phe Cys Lys Ala Leu Phe Tyr Ser Leu Ile 
705                 710                 715                 720 
Ile Ile Gly Thr Leu Gly Lys Lys Ile Lys Gln Tyr Arg Glu Leu Lys 
                725                 730                 735     
Pro Gln Thr Cys Thr Ile Cys Glu Thr Ala Pro Val Asn Ala Ile Asp 
            740                 745                 750         
Ala Glu Met His Asp Leu Asn Cys Ser Tyr Asn Ile Cys Pro Tyr Cys 
        755                 760                 765             
Ala Ser Arg Leu Thr Ser Asp Gly Leu Ala Arg His Val Thr Gln Cys 
    770                 775                 780                 
Pro Lys Arg Lys Glu Lys Val Glu Glu Thr Glu Leu Tyr Leu Asn Leu 
785                 790                 795                 800 
Glu Arg Ile Pro Trp Ile Val Arg Lys Leu Leu Gln Val Ser Glu Ser 
                805                 810                 815     
Thr Gly Val Ala Leu Lys Arg Ser Ser Trp Leu Ile Val Leu Leu Val 
            820                 825                 830         
Leu Leu Thr Val Ser Leu Ser Pro Val Gln Ser Ala Pro Val Gly His 
        835                 840                 845             
Gly Lys Thr Ile Glu Thr Tyr Gln Thr Arg Glu Gly Phe Thr Ser Ile 
    850                 855                 860                 
Cys Leu Phe Met Leu Gly Ser Ile Leu Phe Ile Val Ser Cys Leu Val 
865                 870                 875                 880 
Lys Gly Leu Val Asp Ser Val Ser Asp Ser Phe Phe Pro Gly Leu Ser 
                885                 890                 895     
Val Cys Lys Thr Cys Ser Ile Gly Ser Ile Asn Gly Phe Glu Ile Glu 
            900                 905                 910         
Ser His Lys Cys Tyr Cys Ser Leu Phe Cys Cys Pro Tyr Cys Arg His 
        915                 920                 925             
Cys Ser Ala Asp Arg Glu Ile His Gln Leu His Leu Ser Ile Cys Lys 
    930                 935                 940                 
Lys Arg Lys Thr Gly Ser Asn Val Met Leu Ala Val Cys Lys Arg Met 
945                 950                 955                 960 
Cys Phe Arg Ala Thr Ile Glu Ala Ser Arg Arg Ala Leu Leu Ile Arg 
                965                 970                 975     
Ser Ile Ile Asn Thr Thr Phe Val Ile Cys Ile Leu Thr Leu Thr Ile 
            980                 985                 990         
Cys Val Val Ser Thr Ser Ala Val Glu Met Glu Asn Leu Pro Ala Gly 
        995                 1000                1005            
Thr Trp Glu Arg Glu Glu Asp Leu Thr Asn Phe Cys His Gln Glu Cys 
    1010                1015                1020                
Gln Val Thr Glu Thr Glu Cys Leu Cys Pro Tyr Glu Ala Leu Val Leu 
1025                1030                1035                1040
Arg Lys Pro Leu Phe Leu Asp Ser Ile Val Lys Gly Met Lys Asn Leu 
                1045                1050                1055    
Leu Asn Ser Thr Ser Leu Glu Thr Ser Leu Ser Ile Glu Ala Pro Trp 
            1060                1065                1070        
Gly Ala Ile Asn Val Gln Ser Thr Phe Lys Pro Thr Val Ser Thr Ala 
        1075                1080                1085            
Asn Ile Ala Leu Ser Trp Ser Ser Val Glu His Arg Gly Asn Lys Ile 
    1090                1095                1100                
Leu Val Thr Gly Arg Ser Glu Ser Ile Met Lys Leu Glu Glu Arg Thr 
1105                1110                1115                1120
Gly Val Ser Trp Asp Leu Gly Val Glu Asp Ala Ser Glu Ser Lys Leu 
                1125                1130                1135    
Leu Thr Val Ser Ile Met Asp Leu Ser Gln Met Tyr Ser Pro Val Phe 
            1140                1145                1150        
Glu Tyr Leu Ser Gly Asp Arg Gln Val Glu Glu Trp Pro Lys Ala Thr 
        1155                1160                1165            
Cys Thr Gly Asp Cys Pro Glu Arg Cys Gly Cys Thr Ser Ser Thr Cys 
    1170                1175                1180                
Leu His Lys Glu Trp Pro His Ser Arg Asn Trp Arg Cys Asn Pro Thr 
1185                1190                1195                1200
Trp Cys Trp Gly Val Gly Thr Gly Cys Thr Cys Cys Gly Val Asp Val 
                1205                1210                1215    
Lys Asp Leu Phe Thr Asp His Met Phe Val Lys Trp Lys Val Glu Tyr 
            1220                1225                1230        
Ile Lys Thr Glu Ala Ile Val Cys Val Glu Leu Thr Ser Gln Glu Arg 
        1235                1240                1245            
Gln Cys Ser Leu Ile Glu Ala Gly Thr Arg Phe Asn Leu Gly Pro Val 
    1250                1255                1260                
Thr Ile Thr Leu Ser Glu Pro Arg Asn Ile Gln Gln Lys Leu Pro Pro 
1265                1270                1275                1280
Glu Ile Ile Thr Leu His Pro Lys Ile Glu Glu Gly Phe Phe Asp Leu 
                1285                1290                1295    
Met His Val Gln Lys Val Leu Ser Ala Ser Thr Val Cys Lys Leu Gln 
            1300                1305                1310        
Ser Cys Thr His Gly Ile Pro Gly Asp Leu Gln Val Tyr His Ile Gly 
        1315                1320                1325            
Asn Leu Leu Lys Gly Asp Arg Val Asn Gly His Leu Ile His Lys Ile 
    1330                1335                1340                
Glu Pro His Phe Asn Thr Ser Trp Met Ser Trp Asp Gly Cys Asp Leu 
1345                1350                1355                1360
Asp Tyr Tyr Cys Asn Met Gly Asp Trp Pro Ser Cys Thr Tyr Thr Gly 
                1365                1370                1375    
Val Thr Gln His Asn His Ala Ala Phe Val Asn Leu Leu Asn Ile Glu 
            1380                1385                1390        
Thr Asp Tyr Thr Lys Thr Phe His Phe His Ser Lys Arg Val Thr Ala 
        1395                1400                1405            
His Gly Asp Thr Pro Gln Leu Asp Leu Lys Ala Arg Pro Thr Tyr Gly 
    1410                1415                1420                
Ala Gly Glu Ile Thr Val Leu Val Glu Val Ala Asp Met Glu Leu His 
1425                1430                1435                1440
Thr Lys Lys Val Glu Ile Ser Gly Leu Lys Phe Ala Ser Leu Ala Cys 
                1445                1450                1455    
Thr Gly Cys Tyr Ala Cys Ser Ser Gly Ile Ser Cys Lys Val Arg Ile 
            1460                1465                1470        
His Val Asp Glu Pro Asp Glu Leu Thr Val His Val Lys Ser Ser Asp 
        1475                1480                1485            
Pro Asp Val Val Ala Ala Ser Thr Ser Leu Met Ala Arg Lys Leu Glu 
    1490                1495                1500                
Phe Gly Thr Asp Ser Thr Phe Lys Ala Phe Ser Ala Met Pro Lys Thr 
1505                1510                1515                1520
Ser Leu Cys Phe Tyr Ile Val Glu Arg Glu Tyr Cys Lys Ser Cys Ser 
                1525                1530                1535    
Glu Asp Asp Thr Gln Lys Cys Val Asp Thr Lys Leu Glu Gln Pro Gln 
            1540                1545                1550        
Ser Ile Leu Ile Glu His Lys Gly Thr Ile Ile Gly Lys Gln Asn Asp 
        1555                1560                1565            
Thr Cys Thr Ala Lys Ala Ser Cys Trp Leu Glu Ser Val Lys Ser Phe 
    1570                1575                1580                
Phe Tyr Gly Leu Lys Asn Met Leu Gly Ser Val Phe Gly Asn Phe Phe 
1585                1590                1595                1600
Ile Gly Ile Leu Leu Phe Leu Ala Pro Phe Val Leu Leu Val Leu Phe 
                1605                1610                1615    
Phe Met Phe Gly Trp Lys Ile Leu Phe Cys Phe Lys Cys Cys Arg Arg 
            1620                1625                1630        
Thr Arg Gly Leu Phe Lys Tyr Arg His Leu Lys Asp Asp Glu Glu Thr 
        1635                1640                1645            
Gly Tyr Arg Arg Ile Ile Glu Arg Leu Asn Asn Lys Lys Gly Lys Asn 
    1650                1655                1660                
Arg Leu Leu Asp Gly Glu Arg Leu Ala Asp Arg Lys Ile Ala Glu Leu 
1665                1670                1675                1680
Phe Ser Thr Lys Thr His Ile Gly 
                1685            

<210> 3
<211> 1449
<212> DNA
<213> Artificial Sequence


<220> 
<223> nucleic acid sequence encoding group I-VI of Crimean Congo
      Haemorrhagic Fever Virus BGCA Nucleoprotein

<400> 3
atggagaaca agatcgaggt gaacaacaag gacgagatga acaagtggtt cgaggagttc      60

aagaagggca acggcctggt ggacaccttc accaacagct acagcttctg cgagagcgtg     120

cccaacctgg acaggttcgt gttccagatg gccagcgcca ccgacgacgc ccagaaggac     180

agcatctacg ccagcgccct ggtggaggcc accaagttct gcgcccccat ctacgagtgc     240

gcctgggtga gcagcaccgg catcgtgaag aagggcctgg agtggttcga gaagaacgcc     300

ggcaccatca agagctggga cgagagctac accgagctga aggtggacgt gcccaagatc     360

gagcagctgg ccaactacca gcaggccgcc ctgaagtgga ggaaggacat cggcttcagg     420

gtgaacgcca acaccgccgc cctgagcaac aaggtgctgg ccgagtacaa ggtgcccggc     480

gagatcgtga tgagcgtgaa ggagatgctg agcgacatga tcaggaggag gaacctgatc     540

ctgaacaggg gcggcgacga gaaccccagg ggccccgtga gcagggagca cgtggagtgg     600

tgcagggagt tcgtgaaggg caagtacatc atggccttca accccccctg gggcgacatc     660

aacaagagcg gcaggagcgg catcgccctg gtggccaccg gcctggccaa gctggccgag     720

accgagggca agggcgtgtt cgacgaggcc aagaagaccg tggaggccct gaacggctac     780

ctggacaagc acaaggacga ggtggacaag gccagcgccg acagcatgat caccaacctg     840

ctgaagcaca tcgccaaggc ccaggagctg tacaagaaca gcagcgccct gagggcccag     900

ggcgcccaga tcgacacccc cttcagcagc ttctactggc tgtacaaggc cggcgtgacc     960

cccgagacct tccccaccgt gagccagttc ctgttcgagc tgggcaagca gcccaggggc    1020

accaagaaga tgaagaaggc cctgctgagc acccccatga agtggggcaa gaagctgtac    1080

gagctgttcg ccgacgacag cttccagcag aacaggatct acatgcaccc cgccgtgctg    1140

accgccggca ggatcagcga gatgggcgtg tgcttcggca ccatccccgt ggccaacccc    1200

gacgacgccg cccagggcag cggccacacc aagagcatcc tgaacctgag gaccaacacc    1260

gagaccaaca acccctgcgc caagaccatc gtgaagctgt tcgagatcca gaagaccggc    1320

ttcaacatcc aggacatgga catcgtggcc agcgagcacc tgctgcacca gagcctggtg    1380

ggcaagcaga gccccttcca gaacgcctac aacgtgaagg gcaacgccac cagcgccaac    1440

atcatctaa                                                            1449


<210> 4
<211> 482
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence encoding group I-VI of Crimean Congo
      Haemorrhagic Fever Virus BGCA Nucleoprotein

<400> 4
Met Glu Asn Lys Ile Glu Val Asn Asn Lys Asp Glu Met Asn Lys Trp 
1               5                   10                  15      
Phe Glu Glu Phe Lys Lys Gly Asn Gly Leu Val Asp Thr Phe Thr Asn 
            20                  25                  30          
Ser Tyr Ser Phe Cys Glu Ser Val Pro Asn Leu Asp Arg Phe Val Phe 
        35                  40                  45              
Gln Met Ala Ser Ala Thr Asp Asp Ala Gln Lys Asp Ser Ile Tyr Ala 
    50                  55                  60                  
Ser Ala Leu Val Glu Ala Thr Lys Phe Cys Ala Pro Ile Tyr Glu Cys 
65                  70                  75                  80  
Ala Trp Val Ser Ser Thr Gly Ile Val Lys Lys Gly Leu Glu Trp Phe 
                85                  90                  95      
Glu Lys Asn Ala Gly Thr Ile Lys Ser Trp Asp Glu Ser Tyr Thr Glu 
            100                 105                 110         
Leu Lys Val Asp Val Pro Lys Ile Glu Gln Leu Ala Asn Tyr Gln Gln 
        115                 120                 125             
Ala Ala Leu Lys Trp Arg Lys Asp Ile Gly Phe Arg Val Asn Ala Asn 
    130                 135                 140                 
Thr Ala Ala Leu Ser Asn Lys Val Leu Ala Glu Tyr Lys Val Pro Gly 
145                 150                 155                 160 
Glu Ile Val Met Ser Val Lys Glu Met Leu Ser Asp Met Ile Arg Arg 
                165                 170                 175     
Arg Asn Leu Ile Leu Asn Arg Gly Gly Asp Glu Asn Pro Arg Gly Pro 
            180                 185                 190         
Val Ser Arg Glu His Val Glu Trp Cys Arg Glu Phe Val Lys Gly Lys 
        195                 200                 205             
Tyr Ile Met Ala Phe Asn Pro Pro Trp Gly Asp Ile Asn Lys Ser Gly 
    210                 215                 220                 
Arg Ser Gly Ile Ala Leu Val Ala Thr Gly Leu Ala Lys Leu Ala Glu 
225                 230                 235                 240 
Thr Glu Gly Lys Gly Val Phe Asp Glu Ala Lys Lys Thr Val Glu Ala 
                245                 250                 255     
Leu Asn Gly Tyr Leu Asp Lys His Lys Asp Glu Val Asp Lys Ala Ser 
            260                 265                 270         
Ala Asp Ser Met Ile Thr Asn Leu Leu Lys His Ile Ala Lys Ala Gln 
        275                 280                 285             
Glu Leu Tyr Lys Asn Ser Ser Ala Leu Arg Ala Gln Gly Ala Gln Ile 
    290                 295                 300                 
Asp Thr Pro Phe Ser Ser Phe Tyr Trp Leu Tyr Lys Ala Gly Val Thr 
305                 310                 315                 320 
Pro Glu Thr Phe Pro Thr Val Ser Gln Phe Leu Phe Glu Leu Gly Lys 
                325                 330                 335     
Gln Pro Arg Gly Thr Lys Lys Met Lys Lys Ala Leu Leu Ser Thr Pro 
            340                 345                 350         
Met Lys Trp Gly Lys Lys Leu Tyr Glu Leu Phe Ala Asp Asp Ser Phe 
        355                 360                 365             
Gln Gln Asn Arg Ile Tyr Met His Pro Ala Val Leu Thr Ala Gly Arg 
    370                 375                 380                 
Ile Ser Glu Met Gly Val Cys Phe Gly Thr Ile Pro Val Ala Asn Pro 
385                 390                 395                 400 
Asp Asp Ala Ala Gln Gly Ser Gly His Thr Lys Ser Ile Leu Asn Leu 
                405                 410                 415     
Arg Thr Asn Thr Glu Thr Asn Asn Pro Cys Ala Lys Thr Ile Val Lys 
            420                 425                 430         
Leu Phe Glu Ile Gln Lys Thr Gly Phe Asn Ile Gln Asp Met Asp Ile 
        435                 440                 445             
Val Ala Ser Glu His Leu Leu His Gln Ser Leu Val Gly Lys Gln Ser 
    450                 455                 460                 
Pro Phe Gln Asn Ala Tyr Asn Val Lys Gly Asn Ala Thr Ser Ala Asn 
465                 470                 475                 480 
Ile Ile 
        

<210> 5
<211> 1449
<212> DNA
<213> Artificial Sequence


<220> 
<223> nucleic acid sequence encoding group V of Crimean Congo
      Haemorrhagic Fever Virus BGCA Nucleoprotein

<400> 5
atggaaaaca aaattgaagt gaacagcaaa gatgaaatga acaaatggtt tgaagaattt      60

aaaaaaggca acggcctgat ggataccttt accaacagct atagcttttg cgaaaacgtg     120

ccgaacctgg ataaatttgt gtttcagatg gcgagcgcga ccgatgatgc gcagaaagat     180

agcatttatg cgagcgcgct ggtggaagcg accaaatttt gcgcgccgat ttatgaatgc     240

gcgtgggtga gcagcaccgg cattgtgaaa aaaggcctgg aatggtttga aaaaaacagc     300

ggcaccatta aaagctggga tgaaaactat gcggaactga aagtggatgt gccgaaaatt     360

gaacagctgg cgaactatca gcaggcggcg ctgaaatggc gcaaagatat tggctttcgc     420

gtgaacgcga acaccgcggc gctgagcaac aaagtgctgg cggaatataa agtgccgggc     480

gaaattgtga tgagcgtgaa agaaatgctg agcgatatga ttcgccgccg caacctgatt     540

ctgaaccgcg gcggcgatga aaacccgcgc ggcccggtga gccgcgaaca tgtggaatgg     600

tgccgcgaat ttgtgaaagg caaatatatt atggcgttta acccgccgtg gggcgatatt     660

aacaaaagcg gccgcagcgg cattgcgctg gtggcgaccg gcctggcgaa actggcggaa     720

accgaaggca aaggcgtgtt tgatgaagcg aaaaaaaccg tggaagcgct gaacggctat     780

ctggataaac atcgcgatga agtggataaa gcgagcgcgg atagcatgat taccaacctg     840

ctgaaacata ttgcgaaagc gcaggaactg tataaaaaca gcagcgcgct gcgcgcgcag     900

ggcgcgcaga ttgatacccc gtttagcagc ttttattggc tgtataaagc gggcgtgacc     960

ccggaaacct ttccgaccat tagccagttt ctgtttgaac tgggcaaaca gccgcgcggc    1020

accaaaaaaa tgaaaaaagc gctgctgagc accccgatga aatggggcaa aaaactgtat    1080

gaactgtttg cggatgatag ctttcagcag aaccgcattt atatgcatcc ggcggtgctg    1140

accgcgggcc gcattagcga aatgggcgtg tgctttggca ccattccggt ggcgaacccg    1200

gatgatgcgg cgcagggcag cggccatacc aaaagcattc tgaacctgcg caccagcacc    1260

gaaaccaaca acccgtgcgc gaaaaccatt gtgaaactgt ttgaaattca gaaaaccggc    1320

tttaacattc aggatatgga tattgtggcg agcgaacatc tgctgcatca gagcctggtg    1380

ggcaaacaga gcccgtttca gaacgcgtat aacgtgaaag gcaacgcgac cagcgcgaac    1440

attatttaa                                                            1449


<210> 6
<211> 482
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence encoding group V of Crimean Congo
      Haemorrhagic Fever Virus BGCA Nucleoprotein

<400> 6
Met Glu Asn Lys Ile Glu Val Asn Ser Lys Asp Glu Met Asn Lys Trp 
1               5                   10                  15      
Phe Glu Glu Phe Lys Lys Gly Asn Gly Leu Met Asp Thr Phe Thr Asn 
            20                  25                  30          
Ser Tyr Ser Phe Cys Glu Asn Val Pro Asn Leu Asp Lys Phe Val Phe 
        35                  40                  45              
Gln Met Ala Ser Ala Thr Asp Asp Ala Gln Lys Asp Ser Ile Tyr Ala 
    50                  55                  60                  
Ser Ala Leu Val Glu Ala Thr Lys Phe Cys Ala Pro Ile Tyr Glu Cys 
65                  70                  75                  80  
Ala Trp Val Ser Ser Thr Gly Ile Val Lys Lys Gly Leu Glu Trp Phe 
                85                  90                  95      
Glu Lys Asn Ser Gly Thr Ile Lys Ser Trp Asp Glu Asn Tyr Ala Glu 
            100                 105                 110         
Leu Lys Val Asp Val Pro Lys Ile Glu Gln Leu Ala Asn Tyr Gln Gln 
        115                 120                 125             
Ala Ala Leu Lys Trp Arg Lys Asp Ile Gly Phe Arg Val Asn Ala Asn 
    130                 135                 140                 
Thr Ala Ala Leu Ser Asn Lys Val Leu Ala Glu Tyr Lys Val Pro Gly 
145                 150                 155                 160 
Glu Ile Val Met Ser Val Lys Glu Met Leu Ser Asp Met Ile Arg Arg 
                165                 170                 175     
Arg Asn Leu Ile Leu Asn Arg Gly Gly Asp Glu Asn Pro Arg Gly Pro 
            180                 185                 190         
Val Ser Arg Glu His Val Glu Trp Cys Arg Glu Phe Val Lys Gly Lys 
        195                 200                 205             
Tyr Ile Met Ala Phe Asn Pro Pro Trp Gly Asp Ile Asn Lys Ser Gly 
    210                 215                 220                 
Arg Ser Gly Ile Ala Leu Val Ala Thr Gly Leu Ala Lys Leu Ala Glu 
225                 230                 235                 240 
Thr Glu Gly Lys Gly Val Phe Asp Glu Ala Lys Lys Thr Val Glu Ala 
                245                 250                 255     
Leu Asn Gly Tyr Leu Asp Lys His Arg Asp Glu Val Asp Lys Ala Ser 
            260                 265                 270         
Ala Asp Ser Met Ile Thr Asn Leu Leu Lys His Ile Ala Lys Ala Gln 
        275                 280                 285             
Glu Leu Tyr Lys Asn Ser Ser Ala Leu Arg Ala Gln Gly Ala Gln Ile 
    290                 295                 300                 
Asp Thr Pro Phe Ser Ser Phe Tyr Trp Leu Tyr Lys Ala Gly Val Thr 
305                 310                 315                 320 
Pro Glu Thr Phe Pro Thr Ile Ser Gln Phe Leu Phe Glu Leu Gly Lys 
                325                 330                 335     
Gln Pro Arg Gly Thr Lys Lys Met Lys Lys Ala Leu Leu Ser Thr Pro 
            340                 345                 350         
Met Lys Trp Gly Lys Lys Leu Tyr Glu Leu Phe Ala Asp Asp Ser Phe 
        355                 360                 365             
Gln Gln Asn Arg Ile Tyr Met His Pro Ala Val Leu Thr Ala Gly Arg 
    370                 375                 380                 
Ile Ser Glu Met Gly Val Cys Phe Gly Thr Ile Pro Val Ala Asn Pro 
385                 390                 395                 400 
Asp Asp Ala Ala Gln Gly Ser Gly His Thr Lys Ser Ile Leu Asn Leu 
                405                 410                 415     
Arg Thr Ser Thr Glu Thr Asn Asn Pro Cys Ala Lys Thr Ile Val Lys 
            420                 425                 430         
Leu Phe Glu Ile Gln Lys Thr Gly Phe Asn Ile Gln Asp Met Asp Ile 
        435                 440                 445             
Val Ala Ser Glu His Leu Leu His Gln Ser Leu Val Gly Lys Gln Ser 
    450                 455                 460                 
Pro Phe Gln Asn Ala Tyr Asn Val Lys Gly Asn Ala Thr Ser Ala Asn 
465                 470                 475                 480 
Ile Ile 
        

<210> 7
<211> 1449
<212> DNA
<213> Artificial Sequence


<220> 
<223> nucleic acid sequence encoding Turkey-Kelkit06 Nucleoprotein

<400> 7
atggaaaaca aaatcgaagt gaacagcaaa gatgaaatga acaaatggtt tgaagaattt      60

aaaaaaggca acggtctgat ggataccttt accaacagct attctttctg cgaaaacgtt     120

ccgaatctgg ataaatttgt cttccagatg gcatccgcta cggatgacgc acagaaagac     180

agcatctatg cgtctgccct ggtggaagct accaaatttt gcgcgccgat ttacgaatgt     240

gcgtgggtga gcagcaccgg catcgttaaa aaaggtctgg aatggttcga aaaagatagt     300

ggcaccatta aatcctggga cgaaaactat gccgaactga aagtggatgt tccgaaaatc     360

gaacagctgg caaattacca gcaagcggcc ctgaaatggc gcaaagatat tggctttcgt     420

gtgaacgcta ataccgcagc tctgagtaac aaagtcctgg cggaatataa agtgccgggt     480

gaaatcgtca tgagcgtgaa agaaatgctg tctgatatga ttcgtcgccg taacctgatc     540

ctgaatcgcg gcggtgacga aaatccgcgc ggtccggtta gccgtgaaca tgtcgaatgg     600

tgtcgtgaat ttgtgaaagg caaatacatt atggccttca acccgccgtg gggtgatatt     660

aataaaagtg gccgctccgg tatcgcactg gttgctaccg gcctggcgaa actggccgaa     720

acggaaggca aaggtgtctt tgatgaagcg aagaaaaccg tggaagcact gaatggttat     780

ctggataaac atcgcgatga agtggataaa gcatcagctg actcgatgat tacgaacctg     840

ccgaaacaca tcgcgaaagc ccaggaactg tacaaaaata gttccgcact gcgtgctcag     900

ggcgcgcaaa tcgatacccc gttttcatcg ttctattggc tgtacaaagc cggtgttacg     960

ccggaaacct ttccgacgat ttctcagttt ctgttcgaac tgggcgaaca accgcgtggc    1020

accaagaaaa tgaaaaaagc tctgctgtca acgccgatga aatggggcaa aaaactgtat    1080

gaactgtttg cagatgactc gttccagcaa aaccgcatct acatgcatcc ggccgtgctg    1140

accgcaggtc gtattagcga aatgggcgtg tgcttcggta cgatcccggt tgcaaacccg    1200

gatgacgcag cacagggctc aggtcacacc aaatcgattc tgaatctgcg tacctctacg    1260

gaaaccaaca atccgtgtgc gaaaaccatt gttaaactgt ttgaaatcca ggaaacgggc    1320

ttcaatattc aagatatgga catcgttgcc agtgaacatc tgctgcacca gtccattgtc    1380

ggtaaacaat ccccgttcca aaatgcttac aatgtgaaag gcaatgctac ctcagcgaat    1440

atcatctaa                                                            1449


<210> 8
<211> 482
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence encoding Turkey-Kelkit06 Nucleoprotein

<400> 8
Met Glu Asn Lys Ile Glu Val Asn Ser Lys Asp Glu Met Asn Lys Trp 
1               5                   10                  15      
Phe Glu Glu Phe Lys Lys Gly Asn Gly Leu Met Asp Thr Phe Thr Asn 
            20                  25                  30          
Ser Tyr Ser Phe Cys Glu Asn Val Pro Asn Leu Asp Lys Phe Val Phe 
        35                  40                  45              
Gln Met Ala Ser Ala Thr Asp Asp Ala Gln Lys Asp Ser Ile Tyr Ala 
    50                  55                  60                  
Ser Ala Leu Val Glu Ala Thr Lys Phe Cys Ala Pro Ile Tyr Glu Cys 
65                  70                  75                  80  
Ala Trp Val Ser Ser Thr Gly Ile Val Lys Lys Gly Leu Glu Trp Phe 
                85                  90                  95      
Glu Lys Asp Ser Gly Thr Ile Lys Ser Trp Asp Glu Asn Tyr Ala Glu 
            100                 105                 110         
Leu Lys Val Asp Val Pro Lys Ile Glu Gln Leu Ala Asn Tyr Gln Gln 
        115                 120                 125             
Ala Ala Leu Lys Trp Arg Lys Asp Ile Gly Phe Arg Val Asn Ala Asn 
    130                 135                 140                 
Thr Ala Ala Leu Ser Asn Lys Val Leu Ala Glu Tyr Lys Val Pro Gly 
145                 150                 155                 160 
Glu Ile Val Met Ser Val Lys Glu Met Leu Ser Asp Met Ile Arg Arg 
                165                 170                 175     
Arg Asn Leu Ile Leu Asn Arg Gly Gly Asp Glu Asn Pro Arg Gly Pro 
            180                 185                 190         
Val Ser Arg Glu His Val Glu Trp Cys Arg Glu Phe Val Lys Gly Lys 
        195                 200                 205             
Tyr Ile Met Ala Phe Asn Pro Pro Trp Gly Asp Ile Asn Lys Ser Gly 
    210                 215                 220                 
Arg Ser Gly Ile Ala Leu Val Ala Thr Gly Leu Ala Lys Leu Ala Glu 
225                 230                 235                 240 
Thr Glu Gly Lys Gly Val Phe Asp Glu Ala Lys Lys Thr Val Glu Ala 
                245                 250                 255     
Leu Asn Gly Tyr Leu Asp Lys His Arg Asp Glu Val Asp Lys Ala Ser 
            260                 265                 270         
Ala Asp Ser Met Ile Thr Asn Leu Pro Lys His Ile Ala Lys Ala Gln 
        275                 280                 285             
Glu Leu Tyr Lys Asn Ser Ser Ala Leu Arg Ala Gln Gly Ala Gln Ile 
    290                 295                 300                 
Asp Thr Pro Phe Ser Ser Phe Tyr Trp Leu Tyr Lys Ala Gly Val Thr 
305                 310                 315                 320 
Pro Glu Thr Phe Pro Thr Ile Ser Gln Phe Leu Phe Glu Leu Gly Glu 
                325                 330                 335     
Gln Pro Arg Gly Thr Lys Lys Met Lys Lys Ala Leu Leu Ser Thr Pro 
            340                 345                 350         
Met Lys Trp Gly Lys Lys Leu Tyr Glu Leu Phe Ala Asp Asp Ser Phe 
        355                 360                 365             
Gln Gln Asn Arg Ile Tyr Met His Pro Ala Val Leu Thr Ala Gly Arg 
    370                 375                 380                 
Ile Ser Glu Met Gly Val Cys Phe Gly Thr Ile Pro Val Ala Asn Pro 
385                 390                 395                 400 
Asp Asp Ala Ala Gln Gly Ser Gly His Thr Lys Ser Ile Leu Asn Leu 
                405                 410                 415     
Arg Thr Ser Thr Glu Thr Asn Asn Pro Cys Ala Lys Thr Ile Val Lys 
            420                 425                 430         
Leu Phe Glu Ile Gln Glu Thr Gly Phe Asn Ile Gln Asp Met Asp Ile 
        435                 440                 445             
Val Ala Ser Glu His Leu Leu His Gln Ser Ile Val Gly Lys Gln Ser 
    450                 455                 460                 
Pro Phe Gln Asn Ala Tyr Asn Val Lys Gly Asn Ala Thr Ser Ala Asn 
465                 470                 475                 480 
Ile Ile 
        

<210> 9
<211> 5099
<212> DNA
<213> Artificial Sequence


<220> 
<223> nucleic acid sequence encoding group I of Crimean Congo
      Haemorrhagic Fever Virus BGCA Glycoprotein

<400> 9
atgctgtttc attttaaatt tatgctgctg attaacttta ttctgtgcca gctgctgtgg       60

ggcggcggcg gcgtgaccag cggcgtggaa accaacagca gcagcaccca ggcgattctg      120

accccgccgg tgaccagcaa cagcaccacc ccggcgccgg gcccgagcac cgataccgcg      180

accgaaaccg tgccgagcac caccaccagc accccggata cccaggtgac caccgatagc      240

ggcagcggcg aaccgagcac cgatccgctg accaccaacg aagcgacccc gccgctgagc      300

gtggcgaccg cgcagaccca ggaaaccaaa acccatacca cccagaaccc gagcaccacc      360

accaacccgg atgcgaccac cccgagcatt accaccagca gcgcgccgaa caccagcctg      420

ccgaccagcc cggtgcatgc ggcgaccccg agcccgagca gcagcgaaga accgaccccg      480

cagaacgcgc atcatctgag ccgcagcctg ctgagcgcgg tgagcaccga aaccggccag      540

attgcgagcg cgaccaccac cgcgaaagaa attaccacca aaaacagccc gccgaccgcg      600

ggcaacgata ccatggtgac cccggcgcag aacggcacca ccagcaacac cagcgaacag      660

gcgaacccga ccaccccgga aattagcccg aaaattcaga ccacccagaa ccagcagacc      720

gtgaccccgg aagcgacccc gattaccacc attaccgcgc tgaccgatcc gaccaaccgc      780

agcaaacgcg aaagcaaagt gcagattatt ctgaccttta gccagggcct gaaaaaatat      840

tatagcaaaa ttctgaaact gctgcatctg acccaggaag aagatagcga aggcctgctg      900

gaatggtgca cccgcgtgct ggaacaggcg tgcgatgatg attattttaa cgaacgcatt      960

gaagaatttt ttattaccgg caaaggctat tttaacgatg tgctgcagtt tcgcctgcat     1020

gataccctga gcaccaccga accggcgcag accaccagcc cgaccgcggt gccgtttcgc     1080

agctattatg cgaaaggcag cctgaccttt gatagcggct attttagcgc gaaatgctat     1140

ccgcgcgcga gcaacagcgg cctgcagctg attaacgtga cccagcatcc ggtgaaaatt     1200

gcgaacaccc cgggcccgaa actgagcaac ctgaaaacca ttaactgcat taacctgaaa     1260

gtgagcaccg ataaagaaca tagcgaactg gaaattaacg tgctgctgcc gcaggtggcg     1320

gtgaacctga gcaactgcca tgtgagcatt aaaagccatg tgtgcgatta tagcctggat     1380

accgatggcg cgattaaact gccgaaagtg gcgcataacg gcgtgtttat tccgggcacc     1440

tataaaattg tgattgataa aaaaaacaac ctgaacgatc gctgcgcgct gattaccaac     1500

tgcgtgatta aaggccgcga agtgcgcaaa ggccagagcg cgctgcgcca gtataaaacc     1560

gaaattcgca ttggccagac ctttaccggc agccgccgcc tgctggcgga aggcggcagc     1620

aacgattgcg tgagccgcac ccagctggtg aaaaccgaag tggcggaaat tcatgaagat     1680

agctatggcg gcccgggcga aaaaattacc atttgcaacg gcagcaccat tgtggatcag     1740

cgcctgggca gcgaactggg ctgctatacc attaaccgcg tgcgcaccta taaactgtgc     1800

gaaaacagcg cgaccgaaaa aagctgcgaa attgatagcg tgccggtgaa atgcaaacag     1860

ggcttttgcc tgaaaattac ccaggaaggc cgcggccatg tgaaactgag ccgcggcacc     1920

gaaattgtgc tggatgtgtg cgataccagc tgcgaactga tgattccgaa aggcaccggc     1980

gatattctgg tggattgcag cggcggccag cagcattttc tgcaggataa cctgattgat     2040

ctgggctgcc cgaacgtgcc gctgctgggc aaaatggcga tttatgtgtg ccgcatgagc     2100

aaccatccga aaaccaccat ggcgtttctg ttttggttta gctttggcta tgtgattacc     2160

tgcattgtgt gcaaagtgct gttttatctg ctgattgtga ttggcaccct gggcaaaaaa     2220

ctgaaacagt atcgcgaact gaaaccgcag acctgcattg tgtgcgaaag cgtgccggtg     2280

aacgcgattg atgcggaaat gcatgaactg aactgcaact ataacatttg cccgtattgc     2340

gcgagccgcc tgaccagcga tggcctggtg cgccatgtga cccagtgccc gaaacgcaaa     2400

gaaaaagtgg aagaaaccga actgtatctg aacctggaac gcattccgtg gctggtgcgc     2460

aaactgctgc aggtgagcga aagcaccggc atggcgctga aacgcagctg ctggatgatt     2520

accctgctga ttctgctgct ggtgagcatt agcccggtgc agagcgcgcc ggtgggcaaa     2580

gaacgcgcga ttgaagtgta tcaggcgcgc gaaagctata ccggcatttg cctgtttgtg     2640

ctgggcagcg tgctgtttgc ggtgagctgg ctgaccaaag cgctgattga tggcattggc     2700

aacagctttt ttccgggcct gagcgtgtgc aaaacctgca gcattggcag cattaacggc     2760

tttgaaattg aaagccataa atgctattgc agcctgtttt gctgcccgta ttgccgcgcg     2820

tgcagcagcg ataaaattac ccatcgcatg catctgaacg tgtgcaaaaa acgcaaaatg     2880

ggcagcaacg tgatgctggc ggtgtgcaaa cgcatgtgct ttaaagcgac cattgaagcg     2940

agcaacaaag cgctgctgat tcgcagcatt attaacagca cctttgtgat ttgcattctg     3000

attctggtga tttgcgtggt gagcaccagc gcggtggata tggaaaacct gccggcgggc     3060

atttgggaaa aagaagaaga tctgaccaac ttttgccatc aggaatgcca ggtgaccgaa     3120

accgaatgcc tgtgcccgta tgaagcgctg gtgctgcgca aaccgctgtt tctggatagc     3180

attgcgaaag gcatgaaaag cctgctgaac agcaccagcc tggaaaccag cctgagcatt     3240

gaagcgccgt ggggcgcgat taacgtgcag agcaccttta aaccgaccgt gagcgcggcg     3300

aacattgcgc tgagctggag cagcgtggaa catcgcggca acaaaattct ggtgagcggc     3360

cgcagcgaaa gcattatgaa actggaagaa cgcaccggca ttagctggaa cctgggcgtg     3420

gaagatgcga gcgaaagcaa aaccctgacc gtgagcgtga tggatctgag ccagatgtat     3480

agcccggtgt ttgaatatct gagcggcgat cgccaggtgg aagaatggcc gaaagcgacc     3540

tgcaccggcg attgcccgga acgctgcggc tgcaccagca gcacctgcct gcataaagaa     3600

tggccgcata gccgcaactg gcgctgcaac ccgacctggt gctggggcgt gggcaccggc     3660

tgcacctgct gcggcctgga tgtgaaagat ctgtttaccg attatatgct ggtgaaatgg     3720

aaagtggaat atattaaaac cgaagcgatt gtgtgcgtgg aactgaccag ccaggaacgc     3780

cagtgcagcc tgattgaagc gggcacccgc tttaacctgg gcccggtgac cattaccctg     3840

agcgaaccgc gcaacgtgca gcagcgcctg ccgccggaaa ttgtgaccct gcatccgaaa     3900

attgaagaag gcttttttga tctgatgcat gtgcagaaag tgctgagcgc gagcaccgtg     3960

tgcaaactgc agagctgcac ccatggcgtg ccgggcgatc tgcaggtgta tcatgtgggc     4020

aacctgctga aaggcgataa agtgaacggc catagcattc ataaaattga aagccatttt     4080

aacaccagct ggatgagctg ggatggctgc gatctggatt atttttgcaa catgggcgat     4140

tggccgactg cacctatacc ggcgtgaccc agcataaccg cgcggcgttt attaacatgc     4200

tgaacattga aaccgattat accaaaacct ttcattttca tagcaaacgc gtgaccgcgc     4260

atggcgatac cccgcagctg gatctgaaag cgcgcccggc gtatggcgcg ggcgaagtga     4320

ccgtgctggt ggaagtggcg gatctggaac tgcataccaa aaaaattgaa gtgagcggcc     4380

tgaaatttgc gagcctgacc tgcagcggct gctatgcgtg cagcagcggc attagctgca     4440

aagtgcgcat tcatgtgaac gaaccggatg aatttaccgt gcatgtgaaa agcagcgatc     4500

cggatgtggt ggcggcgggc agcagcctga tggcgcgcaa aattgaattt ggcgcggata     4560

gcacctttaa agcgtttagc agcatgccga aaaacagcct gtgcttttat attgtggaac     4620

gcgattattg cagcagctgc accgatgatg atacccagaa atgcgtgaac accaaactgg     4680

aacatccgca gagcattctg attgaacata aaggcaccat tattggcaaa cagaacgata     4740

cctgcagcac caaaaccagc tgctggctgg aaagcgtgaa aagctttttt tatggcctga     4800

aaaacatgct gagcggcatt tttggcaacg tgtttctggg catttttctg tttctggcgc     4860

cgtttgtgct gctgattttt tttttttttt ttggctggcg cctgctgttt tgcctgaaat     4920

gctgccgccg cacccgcggc ctgctgaaat ataaacatct gaaagatgaa gaagaagcgg     4980

gctataaaaa aattattgaa cgcctgaacg ataaaaaagg caaaagccgc ctgtttgatg     5040

gcgaacgcct ggcggatcgc aaaattgcgg aactgtttag caccaaaacc catattggc      5099


<210> 10
<211> 1700
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence encoding group I of Crimean Congo
      Haemorrhagic Fever Virus BGCA Glycoprotein

<400> 10
Met Leu Phe His Phe Lys Phe Met Leu Leu Ile Asn Phe Ile Leu Cys 
1               5                   10                  15      
Gln Leu Leu Trp Gly Gly Gly Gly Val Thr Ser Gly Val Glu Thr Asn 
            20                  25                  30          
Ser Ser Ser Thr Gln Ala Ile Leu Thr Pro Pro Val Thr Ser Asn Ser 
        35                  40                  45              
Thr Thr Pro Ala Pro Gly Pro Ser Thr Asp Thr Ala Thr Glu Thr Val 
    50                  55                  60                  
Pro Ser Thr Thr Thr Ser Thr Pro Asp Thr Gln Val Thr Thr Asp Ser 
65                  70                  75                  80  
Gly Ser Gly Glu Pro Ser Thr Asp Pro Leu Thr Thr Asn Glu Ala Thr 
                85                  90                  95      
Pro Pro Leu Ser Val Ala Thr Ala Gln Thr Gln Glu Thr Lys Thr His 
            100                 105                 110         
Thr Thr Gln Asn Pro Ser Thr Thr Thr Asn Pro Asp Ala Thr Thr Pro 
        115                 120                 125             
Ser Ile Thr Thr Ser Ser Ala Pro Asn Thr Ser Leu Pro Thr Ser Pro 
    130                 135                 140                 
Val His Ala Ala Thr Pro Ser Pro Ser Ser Ser Glu Glu Pro Thr Pro 
145                 150                 155                 160 
Gln Asn Ala His His Leu Ser Arg Ser Leu Leu Ser Ala Val Ser Thr 
                165                 170                 175     
Glu Thr Gly Gln Ile Ala Ser Ala Thr Thr Thr Ala Lys Glu Ile Thr 
            180                 185                 190         
Thr Lys Asn Ser Pro Pro Thr Ala Gly Asn Asp Thr Met Val Thr Pro 
        195                 200                 205             
Ala Gln Asn Gly Thr Thr Ser Asn Thr Ser Glu Gln Ala Asn Pro Thr 
    210                 215                 220                 
Thr Pro Glu Ile Ser Pro Lys Ile Gln Thr Thr Gln Asn Gln Gln Thr 
225                 230                 235                 240 
Val Thr Pro Glu Ala Thr Pro Ile Thr Thr Ile Thr Ala Leu Thr Asp 
                245                 250                 255     
Pro Thr Asn Arg Ser Lys Arg Glu Ser Lys Val Gln Ile Ile Leu Thr 
            260                 265                 270         
Phe Ser Gln Gly Leu Lys Lys Tyr Tyr Ser Lys Ile Leu Lys Leu Leu 
        275                 280                 285             
His Leu Thr Gln Glu Glu Asp Ser Glu Gly Leu Leu Glu Trp Cys Thr 
    290                 295                 300                 
Arg Val Leu Glu Gln Ala Cys Asp Asp Asp Tyr Phe Asn Glu Arg Ile 
305                 310                 315                 320 
Glu Glu Phe Phe Ile Thr Gly Lys Gly Tyr Phe Asn Asp Val Leu Gln 
                325                 330                 335     
Phe Arg Leu His Asp Thr Leu Ser Thr Thr Glu Pro Ala Gln Thr Thr 
            340                 345                 350         
Ser Pro Thr Ala Val Pro Phe Arg Ser Tyr Tyr Ala Lys Gly Ser Leu 
        355                 360                 365             
Thr Phe Asp Ser Gly Tyr Phe Ser Ala Lys Cys Tyr Pro Arg Ala Ser 
    370                 375                 380                 
Asn Ser Gly Leu Gln Leu Ile Asn Val Thr Gln His Pro Val Lys Ile 
385                 390                 395                 400 
Ala Asn Thr Pro Gly Pro Lys Leu Ser Asn Leu Lys Thr Ile Asn Cys 
                405                 410                 415     
Ile Asn Leu Lys Val Ser Thr Asp Lys Glu His Ser Glu Leu Glu Ile 
            420                 425                 430         
Asn Val Leu Leu Pro Gln Val Ala Val Asn Leu Ser Asn Cys His Val 
        435                 440                 445             
Ser Ile Lys Ser His Val Cys Asp Tyr Ser Leu Asp Thr Asp Gly Ala 
    450                 455                 460                 
Ile Lys Leu Pro Lys Val Ala His Asn Gly Val Phe Ile Pro Gly Thr 
465                 470                 475                 480 
Tyr Lys Ile Val Ile Asp Lys Lys Asn Asn Leu Asn Asp Arg Cys Ala 
                485                 490                 495     
Leu Ile Thr Asn Cys Val Ile Lys Gly Arg Glu Val Arg Lys Gly Gln 
            500                 505                 510         
Ser Ala Leu Arg Gln Tyr Lys Thr Glu Ile Arg Ile Gly Gln Thr Phe 
        515                 520                 525             
Thr Gly Ser Arg Arg Leu Leu Ala Glu Gly Gly Ser Asn Asp Cys Val 
    530                 535                 540                 
Ser Arg Thr Gln Leu Val Lys Thr Glu Val Ala Glu Ile His Glu Asp 
545                 550                 555                 560 
Ser Tyr Gly Gly Pro Gly Glu Lys Ile Thr Ile Cys Asn Gly Ser Thr 
                565                 570                 575     
Ile Val Asp Gln Arg Leu Gly Ser Glu Leu Gly Cys Tyr Thr Ile Asn 
            580                 585                 590         
Arg Val Arg Thr Tyr Lys Leu Cys Glu Asn Ser Ala Thr Glu Lys Ser 
        595                 600                 605             
Cys Glu Ile Asp Ser Val Pro Val Lys Cys Lys Gln Gly Phe Cys Leu 
    610                 615                 620                 
Lys Ile Thr Gln Glu Gly Arg Gly His Val Lys Leu Ser Arg Gly Thr 
625                 630                 635                 640 
Glu Ile Val Leu Asp Val Cys Asp Thr Ser Cys Glu Leu Met Ile Pro 
                645                 650                 655     
Lys Gly Thr Gly Asp Ile Leu Val Asp Cys Ser Gly Gly Gln Gln His 
            660                 665                 670         
Phe Leu Gln Asp Asn Leu Ile Asp Leu Gly Cys Pro Asn Val Pro Leu 
        675                 680                 685             
Leu Gly Lys Met Ala Ile Tyr Val Cys Arg Met Ser Asn His Pro Lys 
    690                 695                 700                 
Thr Thr Met Ala Phe Leu Phe Trp Phe Ser Phe Gly Tyr Val Ile Thr 
705                 710                 715                 720 
Cys Ile Val Cys Lys Val Leu Phe Tyr Leu Leu Ile Val Ile Gly Thr 
                725                 730                 735     
Leu Gly Lys Lys Leu Lys Gln Tyr Arg Glu Leu Lys Pro Gln Thr Cys 
            740                 745                 750         
Ile Val Cys Glu Ser Val Pro Val Asn Ala Ile Asp Ala Glu Met His 
        755                 760                 765             
Glu Leu Asn Cys Asn Tyr Asn Ile Cys Pro Tyr Cys Ala Ser Arg Leu 
    770                 775                 780                 
Thr Ser Asp Gly Leu Val Arg His Val Thr Gln Cys Pro Lys Arg Lys 
785                 790                 795                 800 
Glu Lys Val Glu Glu Thr Glu Leu Tyr Leu Asn Leu Glu Arg Ile Pro 
                805                 810                 815     
Trp Leu Val Arg Lys Leu Leu Gln Val Ser Glu Ser Thr Gly Met Ala 
            820                 825                 830         
Leu Lys Arg Ser Cys Trp Met Ile Thr Leu Leu Ile Leu Leu Leu Val 
        835                 840                 845             
Ser Ile Ser Pro Val Gln Ser Ala Pro Val Gly Lys Glu Arg Ala Ile 
    850                 855                 860                 
Glu Val Tyr Gln Ala Arg Glu Ser Tyr Thr Gly Ile Cys Leu Phe Val 
865                 870                 875                 880 
Leu Gly Ser Val Leu Phe Ala Val Ser Trp Leu Thr Lys Ala Leu Ile 
                885                 890                 895     
Asp Gly Ile Gly Asn Ser Phe Phe Pro Gly Leu Ser Val Cys Lys Thr 
            900                 905                 910         
Cys Ser Ile Gly Ser Ile Asn Gly Phe Glu Ile Glu Ser His Lys Cys 
        915                 920                 925             
Tyr Cys Ser Leu Phe Cys Cys Pro Tyr Cys Arg Ala Cys Ser Ser Asp 
    930                 935                 940                 
Lys Ile Thr His Arg Met His Leu Asn Val Cys Lys Lys Arg Lys Met 
945                 950                 955                 960 
Gly Ser Asn Val Met Leu Ala Val Cys Lys Arg Met Cys Phe Lys Ala 
                965                 970                 975     
Thr Ile Glu Ala Ser Asn Lys Ala Leu Leu Ile Arg Ser Ile Ile Asn 
            980                 985                 990         
Ser Thr Phe Val Ile Cys Ile Leu Ile Leu Val Ile Cys Val Val Ser 
        995                 1000                1005            
Thr Ser Ala Val Asp Met Glu Asn Leu Pro Ala Gly Ile Trp Glu Lys 
    1010                1015                1020                
Glu Glu Asp Leu Thr Asn Phe Cys His Gln Glu Cys Gln Val Thr Glu 
1025                1030                1035                1040
Thr Glu Cys Leu Cys Pro Tyr Glu Ala Leu Val Leu Arg Lys Pro Leu 
                1045                1050                1055    
Phe Leu Asp Ser Ile Ala Lys Gly Met Lys Ser Leu Leu Asn Ser Thr 
            1060                1065                1070        
Ser Leu Glu Thr Ser Leu Ser Ile Glu Ala Pro Trp Gly Ala Ile Asn 
        1075                1080                1085            
Val Gln Ser Thr Phe Lys Pro Thr Val Ser Ala Ala Asn Ile Ala Leu 
    1090                1095                1100                
Ser Trp Ser Ser Val Glu His Arg Gly Asn Lys Ile Leu Val Ser Gly 
1105                1110                1115                1120
Arg Ser Glu Ser Ile Met Lys Leu Glu Glu Arg Thr Gly Ile Ser Trp 
                1125                1130                1135    
Asn Leu Gly Val Glu Asp Ala Ser Glu Ser Lys Thr Leu Thr Val Ser 
            1140                1145                1150        
Val Met Asp Leu Ser Gln Met Tyr Ser Pro Val Phe Glu Tyr Leu Ser 
        1155                1160                1165            
Gly Asp Arg Gln Val Glu Glu Trp Pro Lys Ala Thr Cys Thr Gly Asp 
    1170                1175                1180                
Cys Pro Glu Arg Cys Gly Cys Thr Ser Ser Thr Cys Leu His Lys Glu 
1185                1190                1195                1200
Trp Pro His Ser Arg Asn Trp Arg Cys Asn Pro Thr Trp Cys Trp Gly 
                1205                1210                1215    
Val Gly Thr Gly Cys Thr Cys Cys Gly Leu Asp Val Lys Asp Leu Phe 
            1220                1225                1230        
Thr Asp Tyr Met Leu Val Lys Trp Lys Val Glu Tyr Ile Lys Thr Glu 
        1235                1240                1245            
Ala Ile Val Cys Val Glu Leu Thr Ser Gln Glu Arg Gln Cys Ser Leu 
    1250                1255                1260                
Ile Glu Ala Gly Thr Arg Phe Asn Leu Gly Pro Val Thr Ile Thr Leu 
1265                1270                1275                1280
Ser Glu Pro Arg Asn Val Gln Gln Arg Leu Pro Pro Glu Ile Val Thr 
                1285                1290                1295    
Leu His Pro Lys Ile Glu Glu Gly Phe Phe Asp Leu Met His Val Gln 
            1300                1305                1310        
Lys Val Leu Ser Ala Ser Thr Val Cys Lys Leu Gln Ser Cys Thr His 
        1315                1320                1325            
Gly Val Pro Gly Asp Leu Gln Val Tyr His Val Gly Asn Leu Leu Lys 
    1330                1335                1340                
Gly Asp Lys Val Asn Gly His Ser Ile His Lys Ile Glu Ser His Phe 
1345                1350                1355                1360
Asn Thr Ser Trp Met Ser Trp Asp Gly Cys Asp Leu Asp Tyr Phe Cys 
                1365                1370                1375    
Asn Met Gly Asp Trp Pro Ser Cys Thr Tyr Thr Gly Val Thr Gln His 
            1380                1385                1390        
Asn Arg Ala Ala Phe Ile Asn Met Leu Asn Ile Glu Thr Asp Tyr Thr 
        1395                1400                1405            
Lys Thr Phe His Phe His Ser Lys Arg Val Thr Ala His Gly Asp Thr 
    1410                1415                1420                
Pro Gln Leu Asp Leu Lys Ala Arg Pro Ala Tyr Gly Ala Gly Glu Val 
1425                1430                1435                1440
Thr Val Leu Val Glu Val Ala Asp Leu Glu Leu His Thr Lys Lys Ile 
                1445                1450                1455    
Glu Val Ser Gly Leu Lys Phe Ala Ser Leu Thr Cys Ser Gly Cys Tyr 
            1460                1465                1470        
Ala Cys Ser Ser Gly Ile Ser Cys Lys Val Arg Ile His Val Asn Glu 
        1475                1480                1485            
Pro Asp Glu Phe Thr Val His Val Lys Ser Ser Asp Pro Asp Val Val 
    1490                1495                1500                
Ala Ala Gly Ser Ser Leu Met Ala Arg Lys Ile Glu Phe Gly Ala Asp 
1505                1510                1515                1520
Ser Thr Phe Lys Ala Phe Ser Ser Met Pro Lys Asn Ser Leu Cys Phe 
                1525                1530                1535    
Tyr Ile Val Glu Arg Asp Tyr Cys Ser Ser Cys Thr Asp Asp Asp Thr 
            1540                1545                1550        
Gln Lys Cys Val Asn Thr Lys Leu Glu His Pro Gln Ser Ile Leu Ile 
        1555                1560                1565            
Glu His Lys Gly Thr Ile Ile Gly Lys Gln Asn Asp Thr Cys Ser Thr 
    1570                1575                1580                
Lys Thr Ser Cys Trp Leu Glu Ser Val Lys Ser Phe Phe Tyr Gly Leu 
1585                1590                1595                1600
Lys Asn Met Leu Ser Gly Ile Phe Gly Asn Val Phe Leu Gly Ile Phe 
                1605                1610                1615    
Leu Phe Leu Ala Pro Phe Val Leu Leu Ile Phe Phe Phe Phe Phe Gly 
            1620                1625                1630        
Trp Arg Leu Leu Phe Cys Leu Lys Cys Cys Arg Arg Thr Arg Gly Leu 
        1635                1640                1645            
Leu Lys Tyr Lys His Leu Lys Asp Glu Glu Glu Ala Gly Tyr Lys Lys 
    1650                1655                1660                
Ile Ile Glu Arg Leu Asn Asp Lys Lys Gly Lys Ser Arg Leu Phe Asp 
1665                1670                1675                1680
Gly Glu Arg Leu Ala Asp Arg Lys Ile Ala Glu Leu Phe Ser Thr Lys 
                1685                1690                1695    
Thr His Ile Gly 
            1700

<210> 11
<211> 5052
<212> DNA
<213> Artificial Sequence


<220> 
<223> nucleic acid sequence encoding group III of Crimean Congo
      Haemorrhagic Fever Virus BGCA Glycoprotein

<400> 11
atgcatatta gcctgatgta tgcggtgctg tgcctgcagc tgtgcggcct gggcgaaacc       60

catggcagcc ataacggcac cgaacataac aaaaccgatg tgatgaccac cccgggcgat      120

aaccagagcc cggaaccgcc ggtgagcacc gcgctgccgg tgaccccgga tccgagcacc      180

gtgaccccga ccaccccggc gagcggcctg gaaggcagcg gcgaagtgta taccagcagc      240

ccgattacca ccgaaggcct gagcctgccg gaagcgacca gcgaactgcc ggcgaccacc      300

ggcattgata ccagcagcgc gagcgatgtg gatagcagca cccaggcggc gggcgatacc      360

agcaccccga ccgtgcgcac cagcctgccg aacagcccga gcaccccgag caccagccag      420

gatacccatc atccggtgcg caacctgctg agcgtgacca gcccgaaacc ggaagaaacc      480

agcaccccga gcaaaagcgg caaagaaagc agcgcgacca gcagcccgca tccggtgagc      540

agccgcccgc cgaccccgcc ggcgaccgcg cagggcccga ccgaaaacaa cagccataac      600

gcgaccgaac agctggaaag cctgacccag agcgcgaccc tgggcctgat gaccagcccg      660

acccagaccg tgctgccgca gagcgcgacc agcattgcgg tgcaggatac ccatccgagc      720

ccgaccaacc gcagcaaacg caacctggaa atggaaatta ttctgaccct gagccagggc      780

ctgaaaaaat attatggcaa aattctgcgc ctgctgcatc tgaccctgga agaagatacc      840

gaaggcctgc tggaatggtg caaacgcaac ctgggcctgg attgcgatga tacctttttt      900

cagaaacgca ttgaagaatt ttttattacc ggcgaaggcc attttaacga agtgctgcag      960

tttcgcaccc cgggcaccct gagcaccacc gaaagcaccc atgcgggcag cccgaccgcg     1020

gaaccgttta aaagctattt tgcgaaaggc tttctgagca ttgatagcgg ctattttagc     1080

gcgaaatgct atagccgcac cagcaacagc ggcctgcagc tgattaacgt gacccgccat     1140

agcacccgca ttgcggatac cccgggcccg aaaattacca acctgaaaac cattaactgc     1200

attaacctga aagcgagcgt gtttaaagaa catcgcgaag tggaaattaa cgtgctgctg     1260

ccgcaggtgg cggtgaacct gagcaactgc catgtggtga ttaaaagcca tgtgtgcgat     1320

tatagcctgg atattgatgg caccgtgcgc ctgccgcata ttcatcatga aggcaccttt     1380

attccgggca cctataaaat tgtgattgat aaaaaaaaca aactgaacga tcgctgcacc     1440

ctgtttacca actgcgtgat taaaggccgc gaagtgcgca aaggccagag cgtgctgcgc     1500

cagtataaaa ccgaaattcg cattggcaaa gcgagcaccg gcagccgccg cctgctgagc     1560

gaagaaagcg gcgatgattg cattagccgc acccagctgc tgcgcaccga aaccgcggaa     1620

attcatggcg ataactatgg cggcccgggc gataaaatta ccatttgcaa cggcagcacc     1680

attgtggatc agcgcctggg cagcgaactg ggctgctata ccattaaccg cgtgaaaagc     1740

tttaaactgt gcgaaaacag cgcgaccggc aaaagctgcg aaattgatag cgtgccggtg     1800

aaatgccgcc agggctattg cctgaaaatt acccaggaag gccgcggcca tgtgaaactg     1860

agccgcggca gcgaagtggt gctggatgcg tgcgatagca gctgcgaagt gatgattccg     1920

aaaggcaccg gcgatattct ggtggattgc agcggcggcc agcagcattt tctgaaagat     1980

aacctgattg atctgggctg cccgaaaatt ccgctgctgg gcaaaatggc gatttatatt     2040

tgccgcatga gcaaccatcc gaaaaccacc atggcgtttc tgttttggtt tagctttggc     2100

tatgtgatta cctgcattct gtgcaaagcg attttttatc tgctgattat tgtgggcacc     2160

ctgggcaaac gctttaaaca gtatcgcgaa ctgaaaccgc agacctgcac catttgcgaa     2220

accaccccgg tgaacgcgat tgatgcggaa atgcatgatc tgaactgcag ctataacatt     2280

tgcccgtatt gcgcgagccg cctgaccagc gatggcctgg cgcgccatgt gacccagtgc     2340

ccgaaacgca aagaaaaagt ggaagaaacc gaactgtatc tgaacctgga acgcattccg     2400

tgggtggtgc gcaaactgct gcaggtgagc gaaagcaccg gcgtggcgct gaaacgcagc     2460

agctggctga ttgtgctgct ggtgctgttt accgtgagcc tgagcccggt gcagagcgcg     2520

ccgattggcc atggcaaaac cattgaagcg tatcgcgcgc gcgaaggcta taccagcatt     2580

tgcctgtttg tgctgggcag cattctgttt attgtgagct gcctgatgaa aggcctggtg     2640

gatagcgtgg gcaacatttt ttttccgggc ctgagcattt gcaaaacctg cagcattggc     2700

agcattaacg gctttgaaat tgaaagccat aaatgctatt gcagcctgtt ttgctgcccg     2760

tattgccgcc attgcagcgc ggataaagaa attcatcagc tgcatctgag catttgcaaa     2820

aaacgcaaaa ccggcagcaa cgtgatgctg gcggtgtgca aacgcatgtg ctttcgcgcg     2880

accatggaag tgagcaacaa agcgctgttt attcgcagca ttattaacac cacctttgtg     2940

gtgtgcattc tgattctggc ggtgtgcgtg gtgagcacca gcgcggtgga aatggaaagc     3000

ctgccggcgg gcacctggga acgcgaagaa gatctgacca acttttgcca tcaggaatgc     3060

caggtgaccg aaaccgaatg cctgtgcccg tatgaagcgc tggtgctgcg ccgcccgctg     3120

tttctggata gcattgtgaa aggcatgaaa aacctgctga acagcaccag cctggaaacc     3180

agcctgagca ttgaagcgcc gtggggcgcg attaacgtgc agagcaccta taaaccgacc     3240

gtgagcaccg cgaacattgc gctgagctgg agcagcgtgg aacatcgcgg caacaaaatt     3300

ctggtgagcg gccgcagcga aagcattatg aaactggaag aacgcaccgg cattagctgg     3360

gatctgggcg tggaagatgc gagcgaaagc aaactgctga ccgtgagcgt gatggatctg     3420

agccagatgt atagcccggt gtttgaatat ctgagcggcg atcgccaggt ggaagaatgg     3480

ccgaaagcga cctgcaccgg cgattgcccg gaacgctgcg gctgcaccag cagcacctgc     3540

ctgcataaag aatggccgca tagccgcaac tggcgctgca acccgacctg gtgctggggc     3600

gtgggcaccg gctgcacctg ctgcggcctg gatgtgaaag atctgtttac cgattatatg     3660

tttgtgaaat ggaaagtgga atatattaaa accgaagcga ttgtgtgcgt ggaactgacc     3720

agccaggaac gccagtgcag cctgattgaa gcgggcaccc gctttaacct gggcccggtg     3780

accattaccc tgagcgaacc gcgcaacatt cagcagaaac tgccgccgga aattattacc     3840

ctgcatccgc gcattgaaga aggctttttt gatctgatgc atgtgcagaa agtgctgagc     3900

gcgagcaccg tgtgcaaact gcagagctgc acccatggcg tgccgggcga tctgcaggtg     3960

tatcatattg gcaacctgct gaaaggcgat aaagtgaacg gccatctgat tcataaaatt     4020

gaaccgcatt ttaacaccag ctggatgagc tgggatggct gcgatctgga ttattattgc     4080

aacatgggcg attggccgag ctgcacctat accggcgtga cccagcataa ccatgcgagc     4140

tttgtgaacc tgctgaacat tgaaaccgat tataccaaaa actttcattt tcatagcaaa     4200

cgcgtgaccg cgcatggcga taccccgcag ctggatctga aagcgcgccc gacctatggc     4260

gcgggcgaaa ttaccgtgct ggtggaagtg gcggatatgg aactgcatac caaaaaaatt     4320

gaaattagcg gcctgaaatt tgcgagcctg acctgcaccg gctgctatgc gtgcagcagc     4380

ggcattagct gcaaagtgcg cattcatgtg gatgaaccgg atgaactgac cgtgcatgtg     4440

aaaagcgatg atccggatgt ggtggcggcg agcagcagcc tgatggcgcg caaactggaa     4500

tttggcaccg atagcacctt taaagcgttt agcgcgatgc cgaaaaccag cctgtgcttt     4560

tatattgtgg aacgcgaata ttgcaaaagc tgcagcaaag aagataccca gaaatgcgtg     4620

aacaccaaac tggaacagcc gcagagcatt ctgattgaac ataaaggcac cattattggc     4680

aaacagaaca acacctgcac cgcgaaagcg agctgctggc tggaaagcgt gaaaagcttt     4740

ttttatggcc tgaaaaacat gctgagcggc atttttggca acgtgtttat tggcattttt     4800

ctgtttctgg cgccgtttat tctgctgatt ctgtttttta tgtttggctg gcgcattctg     4860

ttttgcttta aatgctgccg ccgcacccgc ggcctgttta aatatcgcca tctgaaagat     4920

gatgaagaaa ccggctatcg ccgcattatt gaacgcctga acaacaaaaa aggcaaaaac     4980

aaactgctgg atggcgaacg cctggcggat cgccgcattg cggaactgtt tagcaccaaa     5040

acccatattg gc                                                         5052


<210> 12
<211> 1684
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence encoding group III of Crimean Congo
      Haemorrhagic Fever Virus BGCA Glycoprotein

<400> 12
Met His Ile Ser Leu Met Tyr Ala Val Leu Cys Leu Gln Leu Cys Gly 
1               5                   10                  15      
Leu Gly Glu Thr His Gly Ser His Asn Gly Thr Glu His Asn Lys Thr 
            20                  25                  30          
Asp Val Met Thr Thr Pro Gly Asp Asn Gln Ser Pro Glu Pro Pro Val 
        35                  40                  45              
Ser Thr Ala Leu Pro Val Thr Pro Asp Pro Ser Thr Val Thr Pro Thr 
    50                  55                  60                  
Thr Pro Ala Ser Gly Leu Glu Gly Ser Gly Glu Val Tyr Thr Ser Ser 
65                  70                  75                  80  
Pro Ile Thr Thr Glu Gly Leu Ser Leu Pro Glu Ala Thr Ser Glu Leu 
                85                  90                  95      
Pro Ala Thr Thr Gly Ile Asp Thr Ser Ser Ala Ser Asp Val Asp Ser 
            100                 105                 110         
Ser Thr Gln Ala Ala Gly Asp Thr Ser Thr Pro Thr Val Arg Thr Ser 
        115                 120                 125             
Leu Pro Asn Ser Pro Ser Thr Pro Ser Thr Ser Gln Asp Thr His His 
    130                 135                 140                 
Pro Val Arg Asn Leu Leu Ser Val Thr Ser Pro Lys Pro Glu Glu Thr 
145                 150                 155                 160 
Ser Thr Pro Ser Lys Ser Gly Lys Glu Ser Ser Ala Thr Ser Ser Pro 
                165                 170                 175     
His Pro Val Ser Ser Arg Pro Pro Thr Pro Pro Ala Thr Ala Gln Gly 
            180                 185                 190         
Pro Thr Glu Asn Asn Ser His Asn Ala Thr Glu Gln Leu Glu Ser Leu 
        195                 200                 205             
Thr Gln Ser Ala Thr Leu Gly Leu Met Thr Ser Pro Thr Gln Thr Val 
    210                 215                 220                 
Leu Pro Gln Ser Ala Thr Ser Ile Ala Val Gln Asp Thr His Pro Ser 
225                 230                 235                 240 
Pro Thr Asn Arg Ser Lys Arg Asn Leu Glu Met Glu Ile Ile Leu Thr 
                245                 250                 255     
Leu Ser Gln Gly Leu Lys Lys Tyr Tyr Gly Lys Ile Leu Arg Leu Leu 
            260                 265                 270         
His Leu Thr Leu Glu Glu Asp Thr Glu Gly Leu Leu Glu Trp Cys Lys 
        275                 280                 285             
Arg Asn Leu Gly Leu Asp Cys Asp Asp Thr Phe Phe Gln Lys Arg Ile 
    290                 295                 300                 
Glu Glu Phe Phe Ile Thr Gly Glu Gly His Phe Asn Glu Val Leu Gln 
305                 310                 315                 320 
Phe Arg Thr Pro Gly Thr Leu Ser Thr Thr Glu Ser Thr His Ala Gly 
                325                 330                 335     
Ser Pro Thr Ala Glu Pro Phe Lys Ser Tyr Phe Ala Lys Gly Phe Leu 
            340                 345                 350         
Ser Ile Asp Ser Gly Tyr Phe Ser Ala Lys Cys Tyr Ser Arg Thr Ser 
        355                 360                 365             
Asn Ser Gly Leu Gln Leu Ile Asn Val Thr Arg His Ser Thr Arg Ile 
    370                 375                 380                 
Ala Asp Thr Pro Gly Pro Lys Ile Thr Asn Leu Lys Thr Ile Asn Cys 
385                 390                 395                 400 
Ile Asn Leu Lys Ala Ser Val Phe Lys Glu His Arg Glu Val Glu Ile 
                405                 410                 415     
Asn Val Leu Leu Pro Gln Val Ala Val Asn Leu Ser Asn Cys His Val 
            420                 425                 430         
Val Ile Lys Ser His Val Cys Asp Tyr Ser Leu Asp Ile Asp Gly Thr 
        435                 440                 445             
Val Arg Leu Pro His Ile His His Glu Gly Thr Phe Ile Pro Gly Thr 
    450                 455                 460                 
Tyr Lys Ile Val Ile Asp Lys Lys Asn Lys Leu Asn Asp Arg Cys Thr 
465                 470                 475                 480 
Leu Phe Thr Asn Cys Val Ile Lys Gly Arg Glu Val Arg Lys Gly Gln 
                485                 490                 495     
Ser Val Leu Arg Gln Tyr Lys Thr Glu Ile Arg Ile Gly Lys Ala Ser 
            500                 505                 510         
Thr Gly Ser Arg Arg Leu Leu Ser Glu Glu Ser Gly Asp Asp Cys Ile 
        515                 520                 525             
Ser Arg Thr Gln Leu Leu Arg Thr Glu Thr Ala Glu Ile His Gly Asp 
    530                 535                 540                 
Asn Tyr Gly Gly Pro Gly Asp Lys Ile Thr Ile Cys Asn Gly Ser Thr 
545                 550                 555                 560 
Ile Val Asp Gln Arg Leu Gly Ser Glu Leu Gly Cys Tyr Thr Ile Asn 
                565                 570                 575     
Arg Val Lys Ser Phe Lys Leu Cys Glu Asn Ser Ala Thr Gly Lys Ser 
            580                 585                 590         
Cys Glu Ile Asp Ser Val Pro Val Lys Cys Arg Gln Gly Tyr Cys Leu 
        595                 600                 605             
Lys Ile Thr Gln Glu Gly Arg Gly His Val Lys Leu Ser Arg Gly Ser 
    610                 615                 620                 
Glu Val Val Leu Asp Ala Cys Asp Ser Ser Cys Glu Val Met Ile Pro 
625                 630                 635                 640 
Lys Gly Thr Gly Asp Ile Leu Val Asp Cys Ser Gly Gly Gln Gln His 
                645                 650                 655     
Phe Leu Lys Asp Asn Leu Ile Asp Leu Gly Cys Pro Lys Ile Pro Leu 
            660                 665                 670         
Leu Gly Lys Met Ala Ile Tyr Ile Cys Arg Met Ser Asn His Pro Lys 
        675                 680                 685             
Thr Thr Met Ala Phe Leu Phe Trp Phe Ser Phe Gly Tyr Val Ile Thr 
    690                 695                 700                 
Cys Ile Leu Cys Lys Ala Ile Phe Tyr Leu Leu Ile Ile Val Gly Thr 
705                 710                 715                 720 
Leu Gly Lys Arg Phe Lys Gln Tyr Arg Glu Leu Lys Pro Gln Thr Cys 
                725                 730                 735     
Thr Ile Cys Glu Thr Thr Pro Val Asn Ala Ile Asp Ala Glu Met His 
            740                 745                 750         
Asp Leu Asn Cys Ser Tyr Asn Ile Cys Pro Tyr Cys Ala Ser Arg Leu 
        755                 760                 765             
Thr Ser Asp Gly Leu Ala Arg His Val Thr Gln Cys Pro Lys Arg Lys 
    770                 775                 780                 
Glu Lys Val Glu Glu Thr Glu Leu Tyr Leu Asn Leu Glu Arg Ile Pro 
785                 790                 795                 800 
Trp Val Val Arg Lys Leu Leu Gln Val Ser Glu Ser Thr Gly Val Ala 
                805                 810                 815     
Leu Lys Arg Ser Ser Trp Leu Ile Val Leu Leu Val Leu Phe Thr Val 
            820                 825                 830         
Ser Leu Ser Pro Val Gln Ser Ala Pro Ile Gly His Gly Lys Thr Ile 
        835                 840                 845             
Glu Ala Tyr Arg Ala Arg Glu Gly Tyr Thr Ser Ile Cys Leu Phe Val 
    850                 855                 860                 
Leu Gly Ser Ile Leu Phe Ile Val Ser Cys Leu Met Lys Gly Leu Val 
865                 870                 875                 880 
Asp Ser Val Gly Asn Ile Phe Phe Pro Gly Leu Ser Ile Cys Lys Thr 
                885                 890                 895     
Cys Ser Ile Gly Ser Ile Asn Gly Phe Glu Ile Glu Ser His Lys Cys 
            900                 905                 910         
Tyr Cys Ser Leu Phe Cys Cys Pro Tyr Cys Arg His Cys Ser Ala Asp 
        915                 920                 925             
Lys Glu Ile His Gln Leu His Leu Ser Ile Cys Lys Lys Arg Lys Thr 
    930                 935                 940                 
Gly Ser Asn Val Met Leu Ala Val Cys Lys Arg Met Cys Phe Arg Ala 
945                 950                 955                 960 
Thr Met Glu Val Ser Asn Lys Ala Leu Phe Ile Arg Ser Ile Ile Asn 
                965                 970                 975     
Thr Thr Phe Val Val Cys Ile Leu Ile Leu Ala Val Cys Val Val Ser 
            980                 985                 990         
Thr Ser Ala Val Glu Met Glu Ser Leu Pro Ala Gly Thr Trp Glu Arg 
        995                 1000                1005            
Glu Glu Asp Leu Thr Asn Phe Cys His Gln Glu Cys Gln Val Thr Glu 
    1010                1015                1020                
Thr Glu Cys Leu Cys Pro Tyr Glu Ala Leu Val Leu Arg Arg Pro Leu 
1025                1030                1035                1040
Phe Leu Asp Ser Ile Val Lys Gly Met Lys Asn Leu Leu Asn Ser Thr 
                1045                1050                1055    
Ser Leu Glu Thr Ser Leu Ser Ile Glu Ala Pro Trp Gly Ala Ile Asn 
            1060                1065                1070        
Val Gln Ser Thr Tyr Lys Pro Thr Val Ser Thr Ala Asn Ile Ala Leu 
        1075                1080                1085            
Ser Trp Ser Ser Val Glu His Arg Gly Asn Lys Ile Leu Val Ser Gly 
    1090                1095                1100                
Arg Ser Glu Ser Ile Met Lys Leu Glu Glu Arg Thr Gly Ile Ser Trp 
1105                1110                1115                1120
Asp Leu Gly Val Glu Asp Ala Ser Glu Ser Lys Leu Leu Thr Val Ser 
                1125                1130                1135    
Val Met Asp Leu Ser Gln Met Tyr Ser Pro Val Phe Glu Tyr Leu Ser 
            1140                1145                1150        
Gly Asp Arg Gln Val Glu Glu Trp Pro Lys Ala Thr Cys Thr Gly Asp 
        1155                1160                1165            
Cys Pro Glu Arg Cys Gly Cys Thr Ser Ser Thr Cys Leu His Lys Glu 
    1170                1175                1180                
Trp Pro His Ser Arg Asn Trp Arg Cys Asn Pro Thr Trp Cys Trp Gly 
1185                1190                1195                1200
Val Gly Thr Gly Cys Thr Cys Cys Gly Leu Asp Val Lys Asp Leu Phe 
                1205                1210                1215    
Thr Asp Tyr Met Phe Val Lys Trp Lys Val Glu Tyr Ile Lys Thr Glu 
            1220                1225                1230        
Ala Ile Val Cys Val Glu Leu Thr Ser Gln Glu Arg Gln Cys Ser Leu 
        1235                1240                1245            
Ile Glu Ala Gly Thr Arg Phe Asn Leu Gly Pro Val Thr Ile Thr Leu 
    1250                1255                1260                
Ser Glu Pro Arg Asn Ile Gln Gln Lys Leu Pro Pro Glu Ile Ile Thr 
1265                1270                1275                1280
Leu His Pro Arg Ile Glu Glu Gly Phe Phe Asp Leu Met His Val Gln 
                1285                1290                1295    
Lys Val Leu Ser Ala Ser Thr Val Cys Lys Leu Gln Ser Cys Thr His 
            1300                1305                1310        
Gly Val Pro Gly Asp Leu Gln Val Tyr His Ile Gly Asn Leu Leu Lys 
        1315                1320                1325            
Gly Asp Lys Val Asn Gly His Leu Ile His Lys Ile Glu Pro His Phe 
    1330                1335                1340                
Asn Thr Ser Trp Met Ser Trp Asp Gly Cys Asp Leu Asp Tyr Tyr Cys 
1345                1350                1355                1360
Asn Met Gly Asp Trp Pro Ser Cys Thr Tyr Thr Gly Val Thr Gln His 
                1365                1370                1375    
Asn His Ala Ser Phe Val Asn Leu Leu Asn Ile Glu Thr Asp Tyr Thr 
            1380                1385                1390        
Lys Asn Phe His Phe His Ser Lys Arg Val Thr Ala His Gly Asp Thr 
        1395                1400                1405            
Pro Gln Leu Asp Leu Lys Ala Arg Pro Thr Tyr Gly Ala Gly Glu Ile 
    1410                1415                1420                
Thr Val Leu Val Glu Val Ala Asp Met Glu Leu His Thr Lys Lys Ile 
1425                1430                1435                1440
Glu Ile Ser Gly Leu Lys Phe Ala Ser Leu Thr Cys Thr Gly Cys Tyr 
                1445                1450                1455    
Ala Cys Ser Ser Gly Ile Ser Cys Lys Val Arg Ile His Val Asp Glu 
            1460                1465                1470        
Pro Asp Glu Leu Thr Val His Val Lys Ser Asp Asp Pro Asp Val Val 
        1475                1480                1485            
Ala Ala Ser Ser Ser Leu Met Ala Arg Lys Leu Glu Phe Gly Thr Asp 
    1490                1495                1500                
Ser Thr Phe Lys Ala Phe Ser Ala Met Pro Lys Thr Ser Leu Cys Phe 
1505                1510                1515                1520
Tyr Ile Val Glu Arg Glu Tyr Cys Lys Ser Cys Ser Lys Glu Asp Thr 
                1525                1530                1535    
Gln Lys Cys Val Asn Thr Lys Leu Glu Gln Pro Gln Ser Ile Leu Ile 
            1540                1545                1550        
Glu His Lys Gly Thr Ile Ile Gly Lys Gln Asn Asn Thr Cys Thr Ala 
        1555                1560                1565            
Lys Ala Ser Cys Trp Leu Glu Ser Val Lys Ser Phe Phe Tyr Gly Leu 
    1570                1575                1580                
Lys Asn Met Leu Ser Gly Ile Phe Gly Asn Val Phe Ile Gly Ile Phe 
1585                1590                1595                1600
Leu Phe Leu Ala Pro Phe Ile Leu Leu Ile Leu Phe Phe Met Phe Gly 
                1605                1610                1615    
Trp Arg Ile Leu Phe Cys Phe Lys Cys Cys Arg Arg Thr Arg Gly Leu 
            1620                1625                1630        
Phe Lys Tyr Arg His Leu Lys Asp Asp Glu Glu Thr Gly Tyr Arg Arg 
        1635                1640                1645            
Ile Ile Glu Arg Leu Asn Asn Lys Lys Gly Lys Asn Lys Leu Leu Asp 
    1650                1655                1660                
Gly Glu Arg Leu Ala Asp Arg Arg Ile Ala Glu Leu Phe Ser Thr Lys 
1665                1670                1675                1680
Thr His Ile Gly 
                

<210> 13
<211> 5067
<212> DNA
<213> Artificial Sequence


<220> 
<223> nucleic acid sequence encoding group IV of Crimean Congo
      Haemorrhagic Fever Virus BGCA Glycoprotein

<400> 13
atgccgttta acattatgta taccccgctg ctgtgcgcgg tgctgtgcct gcagctgtgg       60

agcctggaag gcacccatgg cctgagcaac aaaacccagc ataacaacac cagcaccacc      120

aaagcgccgg aagaaagcca gggcccgggc ctgccggtga gcaccgcgag cccgattacc      180

agcgatccgc cgagcattac cagcgcggcg agcgcgagcg gcctggaagg cagcggcgat      240

accaacacca gcccgagcgt gaccacccag ggcctgaccc tgccggaaac caccccggaa      300

ccgctgacca ccaccgatac cgatgcgagc agcaccgtgg tggtggatgt gagcacccag      360

accgtgaaag ataccccgac cagcaccacc cataccagcc tgccgagcac cccgagcgcg      420

ccgaccaccc cgcagggcac ccatcatacc gcgcgcggcc tgctgagcgt gaccagcacc      480

aaaccggaag aagcgagcac cccgaccagc ccgggcaaag cgagcaccga aaccagcagc      540

ccgcgcccgg cgattagcga aaccccgagc ccgagcccga ccacccaggc gccgaccgaa      600

aacaacaacc cgaacaccag ccgccagccg atgccgagcg cgcagccggc gaccccgaac      660

ccggtgacca gcccggcgca gccggcgctg agccagagcg ataccagcac cgcggcgcag      720

gatattcatc cgagcccgac caaccgcagc aaacgcaacc tggaaatgga aattattctg      780

accctgagcc agggcctgaa aaaatattat ggcaaaattc tgaaactgct ggatctgacc      840

ctggaagaag ataccgaagg cctgctggaa tggtgcaaac gcaacctggg cctgacctgc      900

gatgataact tttttcagaa acgcattgaa gaattttttc tgaccggcga aggccatttt      960

aacgaagtgc tgcagtttaa aaccccgagc accctgagcc cgaccgaacc ggcgcgcacc     1020

ggcagcccga ccgtggaacc gtttaaaagc tattttgcga aaggctttct gagcatggat     1080

agcggctatt ttagcgcgaa atgctatccg cgcgcgagca acagcggcct gcagctgatt     1140

aacgtgaccc agcatagcgc gcgcattacc gataccccgg gcccgaaaat taccaacctg     1200

aaaaccatta actgcattaa cctgaaagcg agcgtgttta aagaacatcg cgaaattgaa     1260

attaacgtgc tgctgccgca ggtggcggtg aacctgagca actgccatgt gctgattaaa     1320

agccatgtgt gcgattatag cctggatatt gatggcccgg tgcgcctgcc gcgcattcat     1380

catgaaggca cctttattcc gggcacctat aaaattgtga ttgataaaaa aaacaaacag     1440

aacgatcgct gcaccctggt gaccaactgc gtgattaaag gccgcgaaat tcgcaaaggc     1500

cagagcgtgc tgcgccagta tcgcaccgaa attaaaattg gcaaagcgag cagcggcagc     1560

cgccgcctgc tgagcgaaga aagcggcgat gattgcatta gccgcaccca gctgctgcgc     1620

accgaaaccg cggaaattca tagcgataac tatggcggcc cgggcgataa aattaccatt     1680

tgcaacggca gcaccattgt ggatcagcgc ctgggcagcg aactgggctg ctataccatt     1740

aaccgcgtga aaagctttaa actgtgcgaa aacagcgcga ccggcaaaag ctgcgaaatt     1800

gatagcaccc cggtgaaatg ccgccagggc ttttgcctga aaattaccca ggaaggccgc     1860

ggccatgtga aactgagccg cggcagcgaa gtggtgctgg atgcgtgcga tagcagctgc     1920

gaaattatga ttccgaaagg caccggcgat attctggtgg attgcagcgg cggccagcag     1980

cattttctga aagataacct gattgatctg ggctgcccga acattccgct gctgggcaaa     2040

atggcgattt atatttgccg catgagcaac catccgaaaa ccaccatggc gtttctgttt     2100

tggtttagct ttggctatgt gattacctgc attctgtgca aagtgatttt ttatctgctg     2160

attgtggtgg gcaccctggg caaaaaattt aaacagtatc gcgaactgaa accgcagacc     2220

tgcaccattt gcgaaaccac cccggtgaac gcgattgatg cggaaatgca tgatctgaac     2280

tgcagctata acatttgccc gtattgcgcg agccgcctga ccagcgatgg cctggcgcgc     2340

catgtgatgc agtgcccgaa acgcaaagaa aaaattgaag aaaccgaact gtatctgaac     2400

ctggaacgca ttccgtgggt ggtgcgcaaa ctgctgcagg tgagcgaaag caccggcgtg     2460

gcgctgaaac gcagcagctg gctggtggtg ctgctggtgc tgctgaccgt gagcctgagc     2520

ccggtgcaga gcgcgccgat tggccatggc aaaaccgtgg aaacctatca gacccgcgaa     2580

ggctatacca gcatttgcct gtttgtgctg ggcagcattc tgtttattgt gagctgcctg     2640

atgaaaggcc tggtggatag cgtgggcaac agcttttttc cgggcctgag catttgcaaa     2700

acctgcagca ttggcagcat taacggcttt gaaattgaaa gccataaatg ctattgcagc     2760

ctgttttgct gcccgtattg ccgccattgc agcgcggatc gcgaaattca taaactgcat     2820

ctgagcattt gcaaaaaacg caaaaccggc agcaacgtga tgctggcggt gtgcaaacgc     2880

atgtgctttc gcgcgaccgt ggaagtgagc aacaaagcgc tgctgattcg caacattatt     2940

aacaccacct ttgtggtgtg cattctgatt ctggcggtgt gcgtggtgag caccagcgcg     3000

gtggaaatgg aaagcctgcc ggcgggcacc tgggaacgcg aagaagatct gaccaacttt     3060

tgccatcagg aatgccaggt gaccgaaacc gaatgcctgt gcccgtatga agcgctggtg     3120

ctgcgcaaac cgctgtttct ggatagcatt gtgaaaggca tgaaaaacct gctgaacagc     3180

accagcctgg aaaccagcct gagcattgaa gcgccgtggg gcgcgattaa cgtgcagagc     3240

acctttaaac cgaccgtgag cgcggcgaac attgcgctga gctggagcag cgtggaacat     3300

cgcggcaaca aaattctggt gagcggccgc agcgaaagca ttatgaaact ggaagaacgc     3360

accggcatta gctgggatct gggcgtggaa gatgcgagcg aaagcaaact gctgaccgtg     3420

agcgtgatgg atctgagcca gatgtatagc ccggtgtttg aatatctgag cggcgatcgc     3480

caggtggaag aatggccgaa agcgacctgc accggcgatt gcccggaacg ctgcggctgc     3540

accagcagca cctgcctgca taaagaatgg ccgcatagcc gcaactggcg ctgcaacccg     3600

acctggtgct ggggcgtggg caccggctgc acctgctgcg gcctggatgt gaaagatctg     3660

tttaccgatt atatgtttgt gaaatggaaa gtggaatata ttaaaaccga agcgattgtg     3720

tgcgtggaac tgaccagcca ggaacgccag tgcagcctga ttgaagcggg cacccgcttt     3780

aacctgggcc cggtgaccat taccctgagc gaaccgcgca acattcagca gaaactgccg     3840

ccggaaattg tgaccctgca tccgcgcatt gaagaaggct tttttgatct gatgcatgtg     3900

cagaaagtgc tgagcgcgag caccgtgtgc aaactgcaga gctgcaccca tggcgtgccg     3960

ggcgatctgc aggtgtatca tattggcaac ctgctgaaag gcgataaagt gaacggccat     4020

ctgattcata aaattgaacc gcattttaac accagctgga tgagctggga tggctgcgat     4080

ctggattatt attgcaacat gggcgattgg ccgagctgca cctataccgg cgtgacccag     4140

cataaccatg cggcgtttgt gaacatgctg aacattgaaa ccgattatac caaaaacttt     4200

cattttcata gcaaacgcgt gaccgcgcat ggcgataccc cgcagctgga tctgaaagcg     4260

cgcccgacct atggcgcggg cgaaattacc gtgctggtgg aagtggcgga tatggaactg     4320

cataccaaaa aaattgaaat tagcggcctg aaatttgcga gcctgacctg caccggctgc     4380

tatgcgtgca gcagcggcat tagctgcaaa gtgcgcattc atgtggatga accggatgaa     4440

ctgaccgtgc atgtgaaaag cgaagatccg gatattgtgg cggcgagcag cagcctgatg     4500

gcgcgcaaac tggaatttgg caccgatagc acctttaaag cgtttagcgc gatgccgaaa     4560

accagcctgt gcttttatat tgtggaacgc gaatattgca aaagctgcag caaagaagat     4620

acccagaaat gcgtgaacac caaactggaa cagccgcaga gcattctgat tgaacataaa     4680

ggcaccatta ttggcaaaca gaacgatacc tgcaccgcga aagcgagctg ctggctggaa     4740

agcgtgaaaa gcttttttta tggcctgaaa aacatgctga gcggcatttt tggcaacgtg     4800

tttattggca tttttctgtt tctggcgccg tttattctgc tgattctgtt ttttatgttt     4860

ggctggcgca ttctgttttg ctttaaatgc tgccgccgca cccgcggcct gtttaaatat     4920

cgccatctga aagatgatga agaaaccggc tatcgcaaaa ttattgaacg cctgaacaac     4980

aaaaaaggca aaaacaaact gctggatggc gaacgcctgg cggatcgcaa aattgcggaa     5040

ctgtttagca ccaaaaccca tattggc                                         5067


<210> 14
<211> 1689
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence encoding group IV of Crimean Congo
      Haemorrhagic Fever Virus BGCA Glycoprotein

<400> 14
Met Pro Phe Asn Ile Met Tyr Thr Pro Leu Leu Cys Ala Val Leu Cys 
1               5                   10                  15      
Leu Gln Leu Trp Ser Leu Glu Gly Thr His Gly Leu Ser Asn Lys Thr 
            20                  25                  30          
Gln His Asn Asn Thr Ser Thr Thr Lys Ala Pro Glu Glu Ser Gln Gly 
        35                  40                  45              
Pro Gly Leu Pro Val Ser Thr Ala Ser Pro Ile Thr Ser Asp Pro Pro 
    50                  55                  60                  
Ser Ile Thr Ser Ala Ala Ser Ala Ser Gly Leu Glu Gly Ser Gly Asp 
65                  70                  75                  80  
Thr Asn Thr Ser Pro Ser Val Thr Thr Gln Gly Leu Thr Leu Pro Glu 
                85                  90                  95      
Thr Thr Pro Glu Pro Leu Thr Thr Thr Asp Thr Asp Ala Ser Ser Thr 
            100                 105                 110         
Val Val Val Asp Val Ser Thr Gln Thr Val Lys Asp Thr Pro Thr Ser 
        115                 120                 125             
Thr Thr His Thr Ser Leu Pro Ser Thr Pro Ser Ala Pro Thr Thr Pro 
    130                 135                 140                 
Gln Gly Thr His His Thr Ala Arg Gly Leu Leu Ser Val Thr Ser Thr 
145                 150                 155                 160 
Lys Pro Glu Glu Ala Ser Thr Pro Thr Ser Pro Gly Lys Ala Ser Thr 
                165                 170                 175     
Glu Thr Ser Ser Pro Arg Pro Ala Ile Ser Glu Thr Pro Ser Pro Ser 
            180                 185                 190         
Pro Thr Thr Gln Ala Pro Thr Glu Asn Asn Asn Pro Asn Thr Ser Arg 
        195                 200                 205             
Gln Pro Met Pro Ser Ala Gln Pro Ala Thr Pro Asn Pro Val Thr Ser 
    210                 215                 220                 
Pro Ala Gln Pro Ala Leu Ser Gln Ser Asp Thr Ser Thr Ala Ala Gln 
225                 230                 235                 240 
Asp Ile His Pro Ser Pro Thr Asn Arg Ser Lys Arg Asn Leu Glu Met 
                245                 250                 255     
Glu Ile Ile Leu Thr Leu Ser Gln Gly Leu Lys Lys Tyr Tyr Gly Lys 
            260                 265                 270         
Ile Leu Lys Leu Leu Asp Leu Thr Leu Glu Glu Asp Thr Glu Gly Leu 
        275                 280                 285             
Leu Glu Trp Cys Lys Arg Asn Leu Gly Leu Thr Cys Asp Asp Asn Phe 
    290                 295                 300                 
Phe Gln Lys Arg Ile Glu Glu Phe Phe Leu Thr Gly Glu Gly His Phe 
305                 310                 315                 320 
Asn Glu Val Leu Gln Phe Lys Thr Pro Ser Thr Leu Ser Pro Thr Glu 
                325                 330                 335     
Pro Ala Arg Thr Gly Ser Pro Thr Val Glu Pro Phe Lys Ser Tyr Phe 
            340                 345                 350         
Ala Lys Gly Phe Leu Ser Met Asp Ser Gly Tyr Phe Ser Ala Lys Cys 
        355                 360                 365             
Tyr Pro Arg Ala Ser Asn Ser Gly Leu Gln Leu Ile Asn Val Thr Gln 
    370                 375                 380                 
His Ser Ala Arg Ile Thr Asp Thr Pro Gly Pro Lys Ile Thr Asn Leu 
385                 390                 395                 400 
Lys Thr Ile Asn Cys Ile Asn Leu Lys Ala Ser Val Phe Lys Glu His 
                405                 410                 415     
Arg Glu Ile Glu Ile Asn Val Leu Leu Pro Gln Val Ala Val Asn Leu 
            420                 425                 430         
Ser Asn Cys His Val Leu Ile Lys Ser His Val Cys Asp Tyr Ser Leu 
        435                 440                 445             
Asp Ile Asp Gly Pro Val Arg Leu Pro Arg Ile His His Glu Gly Thr 
    450                 455                 460                 
Phe Ile Pro Gly Thr Tyr Lys Ile Val Ile Asp Lys Lys Asn Lys Gln 
465                 470                 475                 480 
Asn Asp Arg Cys Thr Leu Val Thr Asn Cys Val Ile Lys Gly Arg Glu 
                485                 490                 495     
Ile Arg Lys Gly Gln Ser Val Leu Arg Gln Tyr Arg Thr Glu Ile Lys 
            500                 505                 510         
Ile Gly Lys Ala Ser Ser Gly Ser Arg Arg Leu Leu Ser Glu Glu Ser 
        515                 520                 525             
Gly Asp Asp Cys Ile Ser Arg Thr Gln Leu Leu Arg Thr Glu Thr Ala 
    530                 535                 540                 
Glu Ile His Ser Asp Asn Tyr Gly Gly Pro Gly Asp Lys Ile Thr Ile 
545                 550                 555                 560 
Cys Asn Gly Ser Thr Ile Val Asp Gln Arg Leu Gly Ser Glu Leu Gly 
                565                 570                 575     
Cys Tyr Thr Ile Asn Arg Val Lys Ser Phe Lys Leu Cys Glu Asn Ser 
            580                 585                 590         
Ala Thr Gly Lys Ser Cys Glu Ile Asp Ser Thr Pro Val Lys Cys Arg 
        595                 600                 605             
Gln Gly Phe Cys Leu Lys Ile Thr Gln Glu Gly Arg Gly His Val Lys 
    610                 615                 620                 
Leu Ser Arg Gly Ser Glu Val Val Leu Asp Ala Cys Asp Ser Ser Cys 
625                 630                 635                 640 
Glu Ile Met Ile Pro Lys Gly Thr Gly Asp Ile Leu Val Asp Cys Ser 
                645                 650                 655     
Gly Gly Gln Gln His Phe Leu Lys Asp Asn Leu Ile Asp Leu Gly Cys 
            660                 665                 670         
Pro Asn Ile Pro Leu Leu Gly Lys Met Ala Ile Tyr Ile Cys Arg Met 
        675                 680                 685             
Ser Asn His Pro Lys Thr Thr Met Ala Phe Leu Phe Trp Phe Ser Phe 
    690                 695                 700                 
Gly Tyr Val Ile Thr Cys Ile Leu Cys Lys Val Ile Phe Tyr Leu Leu 
705                 710                 715                 720 
Ile Val Val Gly Thr Leu Gly Lys Lys Phe Lys Gln Tyr Arg Glu Leu 
                725                 730                 735     
Lys Pro Gln Thr Cys Thr Ile Cys Glu Thr Thr Pro Val Asn Ala Ile 
            740                 745                 750         
Asp Ala Glu Met His Asp Leu Asn Cys Ser Tyr Asn Ile Cys Pro Tyr 
        755                 760                 765             
Cys Ala Ser Arg Leu Thr Ser Asp Gly Leu Ala Arg His Val Met Gln 
    770                 775                 780                 
Cys Pro Lys Arg Lys Glu Lys Ile Glu Glu Thr Glu Leu Tyr Leu Asn 
785                 790                 795                 800 
Leu Glu Arg Ile Pro Trp Val Val Arg Lys Leu Leu Gln Val Ser Glu 
                805                 810                 815     
Ser Thr Gly Val Ala Leu Lys Arg Ser Ser Trp Leu Val Val Leu Leu 
            820                 825                 830         
Val Leu Leu Thr Val Ser Leu Ser Pro Val Gln Ser Ala Pro Ile Gly 
        835                 840                 845             
His Gly Lys Thr Val Glu Thr Tyr Gln Thr Arg Glu Gly Tyr Thr Ser 
    850                 855                 860                 
Ile Cys Leu Phe Val Leu Gly Ser Ile Leu Phe Ile Val Ser Cys Leu 
865                 870                 875                 880 
Met Lys Gly Leu Val Asp Ser Val Gly Asn Ser Phe Phe Pro Gly Leu 
                885                 890                 895     
Ser Ile Cys Lys Thr Cys Ser Ile Gly Ser Ile Asn Gly Phe Glu Ile 
            900                 905                 910         
Glu Ser His Lys Cys Tyr Cys Ser Leu Phe Cys Cys Pro Tyr Cys Arg 
        915                 920                 925             
His Cys Ser Ala Asp Arg Glu Ile His Lys Leu His Leu Ser Ile Cys 
    930                 935                 940                 
Lys Lys Arg Lys Thr Gly Ser Asn Val Met Leu Ala Val Cys Lys Arg 
945                 950                 955                 960 
Met Cys Phe Arg Ala Thr Val Glu Val Ser Asn Lys Ala Leu Leu Ile 
                965                 970                 975     
Arg Asn Ile Ile Asn Thr Thr Phe Val Val Cys Ile Leu Ile Leu Ala 
            980                 985                 990         
Val Cys Val Val Ser Thr Ser Ala Val Glu Met Glu Ser Leu Pro Ala 
        995                 1000                1005            
Gly Thr Trp Glu Arg Glu Glu Asp Leu Thr Asn Phe Cys His Gln Glu 
    1010                1015                1020                
Cys Gln Val Thr Glu Thr Glu Cys Leu Cys Pro Tyr Glu Ala Leu Val 
1025                1030                1035                1040
Leu Arg Lys Pro Leu Phe Leu Asp Ser Ile Val Lys Gly Met Lys Asn 
                1045                1050                1055    
Leu Leu Asn Ser Thr Ser Leu Glu Thr Ser Leu Ser Ile Glu Ala Pro 
            1060                1065                1070        
Trp Gly Ala Ile Asn Val Gln Ser Thr Phe Lys Pro Thr Val Ser Ala 
        1075                1080                1085            
Ala Asn Ile Ala Leu Ser Trp Ser Ser Val Glu His Arg Gly Asn Lys 
    1090                1095                1100                
Ile Leu Val Ser Gly Arg Ser Glu Ser Ile Met Lys Leu Glu Glu Arg 
1105                1110                1115                1120
Thr Gly Ile Ser Trp Asp Leu Gly Val Glu Asp Ala Ser Glu Ser Lys 
                1125                1130                1135    
Leu Leu Thr Val Ser Val Met Asp Leu Ser Gln Met Tyr Ser Pro Val 
            1140                1145                1150        
Phe Glu Tyr Leu Ser Gly Asp Arg Gln Val Glu Glu Trp Pro Lys Ala 
        1155                1160                1165            
Thr Cys Thr Gly Asp Cys Pro Glu Arg Cys Gly Cys Thr Ser Ser Thr 
    1170                1175                1180                
Cys Leu His Lys Glu Trp Pro His Ser Arg Asn Trp Arg Cys Asn Pro 
1185                1190                1195                1200
Thr Trp Cys Trp Gly Val Gly Thr Gly Cys Thr Cys Cys Gly Leu Asp 
                1205                1210                1215    
Val Lys Asp Leu Phe Thr Asp Tyr Met Phe Val Lys Trp Lys Val Glu 
            1220                1225                1230        
Tyr Ile Lys Thr Glu Ala Ile Val Cys Val Glu Leu Thr Ser Gln Glu 
        1235                1240                1245            
Arg Gln Cys Ser Leu Ile Glu Ala Gly Thr Arg Phe Asn Leu Gly Pro 
    1250                1255                1260                
Val Thr Ile Thr Leu Ser Glu Pro Arg Asn Ile Gln Gln Lys Leu Pro 
1265                1270                1275                1280
Pro Glu Ile Val Thr Leu His Pro Arg Ile Glu Glu Gly Phe Phe Asp 
                1285                1290                1295    
Leu Met His Val Gln Lys Val Leu Ser Ala Ser Thr Val Cys Lys Leu 
            1300                1305                1310        
Gln Ser Cys Thr His Gly Val Pro Gly Asp Leu Gln Val Tyr His Ile 
        1315                1320                1325            
Gly Asn Leu Leu Lys Gly Asp Lys Val Asn Gly His Leu Ile His Lys 
    1330                1335                1340                
Ile Glu Pro His Phe Asn Thr Ser Trp Met Ser Trp Asp Gly Cys Asp 
1345                1350                1355                1360
Leu Asp Tyr Tyr Cys Asn Met Gly Asp Trp Pro Ser Cys Thr Tyr Thr 
                1365                1370                1375    
Gly Val Thr Gln His Asn His Ala Ala Phe Val Asn Met Leu Asn Ile 
            1380                1385                1390        
Glu Thr Asp Tyr Thr Lys Asn Phe His Phe His Ser Lys Arg Val Thr 
        1395                1400                1405            
Ala His Gly Asp Thr Pro Gln Leu Asp Leu Lys Ala Arg Pro Thr Tyr 
    1410                1415                1420                
Gly Ala Gly Glu Ile Thr Val Leu Val Glu Val Ala Asp Met Glu Leu 
1425                1430                1435                1440
His Thr Lys Lys Ile Glu Ile Ser Gly Leu Lys Phe Ala Ser Leu Thr 
                1445                1450                1455    
Cys Thr Gly Cys Tyr Ala Cys Ser Ser Gly Ile Ser Cys Lys Val Arg 
            1460                1465                1470        
Ile His Val Asp Glu Pro Asp Glu Leu Thr Val His Val Lys Ser Glu 
        1475                1480                1485            
Asp Pro Asp Ile Val Ala Ala Ser Ser Ser Leu Met Ala Arg Lys Leu 
    1490                1495                1500                
Glu Phe Gly Thr Asp Ser Thr Phe Lys Ala Phe Ser Ala Met Pro Lys 
1505                1510                1515                1520
Thr Ser Leu Cys Phe Tyr Ile Val Glu Arg Glu Tyr Cys Lys Ser Cys 
                1525                1530                1535    
Ser Lys Glu Asp Thr Gln Lys Cys Val Asn Thr Lys Leu Glu Gln Pro 
            1540                1545                1550        
Gln Ser Ile Leu Ile Glu His Lys Gly Thr Ile Ile Gly Lys Gln Asn 
        1555                1560                1565            
Asp Thr Cys Thr Ala Lys Ala Ser Cys Trp Leu Glu Ser Val Lys Ser 
    1570                1575                1580                
Phe Phe Tyr Gly Leu Lys Asn Met Leu Ser Gly Ile Phe Gly Asn Val 
1585                1590                1595                1600
Phe Ile Gly Ile Phe Leu Phe Leu Ala Pro Phe Ile Leu Leu Ile Leu 
                1605                1610                1615    
Phe Phe Met Phe Gly Trp Arg Ile Leu Phe Cys Phe Lys Cys Cys Arg 
            1620                1625                1630        
Arg Thr Arg Gly Leu Phe Lys Tyr Arg His Leu Lys Asp Asp Glu Glu 
        1635                1640                1645            
Thr Gly Tyr Arg Lys Ile Ile Glu Arg Leu Asn Asn Lys Lys Gly Lys 
    1650                1655                1660                
Asn Lys Leu Leu Asp Gly Glu Arg Leu Ala Asp Arg Lys Ile Ala Glu 
1665                1670                1675                1680
Leu Phe Ser Thr Lys Thr His Ile Gly 
                1685                

