                         SEQUENCE LISTING

<110>  ATSO Corporate Affairs
       ROJAS, Alberto Checa
       GODNEZ, Orlando Santilln
       Palestino, Ral Domnguez
 
<120>  METHODS OF DIAGNOSING AND TREATING CERVICAL CANCER

<130>  ATSO1100-1WO

<150>  MX/a/2019/005940
<151>  2019-05-21

<160>  147   

<170>  PatentIn version 3.5

<210>  1
<211>  419
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Farnesyl pyrophosphate synthase (FDPS)

<400>  1

Met Pro Leu Ser Arg Trp Leu Arg Ser Val Gly Val Phe Leu Leu Pro 
1               5                   10                  15      


Ala Pro Tyr Trp Ala Pro Arg Glu Arg Trp Leu Gly Ser Leu Arg Arg 
            20                  25                  30          


Pro Ser Leu Val His Gly Tyr Pro Val Leu Ala Trp His Ser Ala Arg 
        35                  40                  45              


Cys Trp Cys Gln Ala Trp Thr Glu Glu Pro Arg Ala Leu Cys Ser Ser 
    50                  55                  60                  


Leu Arg Met Asn Gly Asp Gln Asn Ser Asp Val Tyr Ala Gln Glu Lys 
65                  70                  75                  80  


Gln Asp Phe Val Gln His Phe Ser Gln Ile Val Arg Val Leu Thr Glu 
                85                  90                  95      


Asp Glu Met Gly His Pro Glu Ile Gly Asp Ala Ile Ala Arg Leu Lys 
            100                 105                 110         


Glu Val Leu Glu Tyr Asn Ala Ile Gly Gly Lys Tyr Asn Arg Gly Leu 
        115                 120                 125             


Thr Val Val Val Ala Phe Arg Glu Leu Val Glu Pro Arg Lys Gln Asp 
    130                 135                 140                 


Ala Asp Ser Leu Gln Arg Ala Trp Thr Val Gly Trp Cys Val Glu Leu 
145                 150                 155                 160 


Leu Gln Ala Phe Phe Leu Val Ala Asp Asp Ile Met Asp Ser Ser Leu 
                165                 170                 175     


Thr Arg Arg Gly Gln Ile Cys Trp Tyr Gln Lys Pro Gly Val Gly Leu 
            180                 185                 190         


Asp Ala Ile Asn Asp Ala Asn Leu Leu Glu Ala Cys Ile Tyr Arg Leu 
        195                 200                 205             


Leu Lys Leu Tyr Cys Arg Glu Gln Pro Tyr Tyr Leu Asn Leu Ile Glu 
    210                 215                 220                 


Leu Phe Leu Gln Ser Ser Tyr Gln Thr Glu Ile Gly Gln Thr Leu Asp 
225                 230                 235                 240 


Leu Leu Thr Ala Pro Gln Gly Asn Val Asp Leu Val Arg Phe Thr Glu 
                245                 250                 255     


Lys Arg Tyr Lys Ser Ile Val Lys Tyr Lys Thr Ala Phe Tyr Ser Phe 
            260                 265                 270         


Tyr Leu Pro Ile Ala Ala Ala Met Tyr Met Ala Gly Ile Asp Gly Glu 
        275                 280                 285             


Lys Glu His Ala Asn Ala Lys Lys Ile Leu Leu Glu Met Gly Glu Phe 
    290                 295                 300                 


Phe Gln Ile Gln Asp Asp Tyr Leu Asp Leu Phe Gly Asp Pro Ser Val 
305                 310                 315                 320 


Thr Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu 
                325                 330                 335     


Val Val Gln Cys Leu Gln Arg Ala Thr Pro Glu Gln Tyr Gln Ile Leu 
            340                 345                 350         


Lys Glu Asn Tyr Gly Gln Lys Glu Ala Glu Lys Val Ala Arg Val Lys 
        355                 360                 365             


Ala Leu Tyr Glu Glu Leu Asp Leu Pro Ala Val Phe Leu Gln Tyr Glu 
    370                 375                 380                 


Glu Asp Ser Tyr Ser His Ile Met Ala Leu Ile Glu Gln Tyr Ala Ala 
385                 390                 395                 400 


Pro Leu Pro Pro Ala Val Phe Leu Gly Leu Ala Arg Lys Ile Tyr Lys 
                405                 410                 415     


Arg Arg Lys 
            


<210>  2
<211>  2839
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Neurofibromin 1 (NF1)

<400>  2

Met Ala Ala His Arg Pro Val Glu Trp Val Gln Ala Val Val Ser Arg 
1               5                   10                  15      


Phe Asp Glu Gln Leu Pro Ile Lys Thr Gly Gln Gln Asn Thr His Thr 
            20                  25                  30          


Lys Val Ser Thr Glu His Asn Lys Glu Cys Leu Ile Asn Ile Ser Lys 
        35                  40                  45              


Tyr Lys Phe Ser Leu Val Ile Ser Gly Leu Thr Thr Ile Leu Lys Asn 
    50                  55                  60                  


Val Asn Asn Met Arg Ile Phe Gly Glu Ala Ala Glu Lys Asn Leu Tyr 
65                  70                  75                  80  


Leu Ser Gln Leu Ile Ile Leu Asp Thr Leu Glu Lys Cys Leu Ala Gly 
                85                  90                  95      


Gln Pro Lys Asp Thr Met Arg Leu Asp Glu Thr Met Leu Val Lys Gln 
            100                 105                 110         


Leu Leu Pro Glu Ile Cys His Phe Leu His Thr Cys Arg Glu Gly Asn 
        115                 120                 125             


Gln His Ala Ala Glu Leu Arg Asn Ser Ala Ser Gly Val Leu Phe Ser 
    130                 135                 140                 


Leu Ser Cys Asn Asn Phe Asn Ala Val Phe Ser Arg Ile Ser Thr Arg 
145                 150                 155                 160 


Leu Gln Glu Leu Thr Val Cys Ser Glu Asp Asn Val Asp Val His Asp 
                165                 170                 175     


Ile Glu Leu Leu Gln Tyr Ile Asn Val Asp Cys Ala Lys Leu Lys Arg 
            180                 185                 190         


Leu Leu Lys Glu Thr Ala Phe Lys Phe Lys Ala Leu Lys Lys Val Ala 
        195                 200                 205             


Gln Leu Ala Val Ile Asn Ser Leu Glu Lys Ala Phe Trp Asn Trp Val 
    210                 215                 220                 


Glu Asn Tyr Pro Asp Glu Phe Thr Lys Leu Tyr Gln Ile Pro Gln Thr 
225                 230                 235                 240 


Asp Met Ala Glu Cys Ala Glu Lys Leu Phe Asp Leu Val Asp Gly Phe 
                245                 250                 255     


Ala Glu Ser Thr Lys Arg Lys Ala Ala Val Trp Pro Leu Gln Ile Ile 
            260                 265                 270         


Leu Leu Ile Leu Cys Pro Glu Ile Ile Gln Asp Ile Ser Lys Asp Val 
        275                 280                 285             


Val Asp Glu Asn Asn Met Asn Lys Lys Leu Phe Leu Asp Ser Leu Arg 
    290                 295                 300                 


Lys Ala Leu Ala Gly His Gly Gly Ser Arg Gln Leu Thr Glu Ser Ala 
305                 310                 315                 320 


Ala Ile Ala Cys Val Lys Leu Cys Lys Ala Ser Thr Tyr Ile Asn Trp 
                325                 330                 335     


Glu Asp Asn Ser Val Ile Phe Leu Leu Val Gln Ser Met Val Val Asp 
            340                 345                 350         


Leu Lys Asn Leu Leu Phe Asn Pro Ser Lys Pro Phe Ser Arg Gly Ser 
        355                 360                 365             


Gln Pro Ala Asp Val Asp Leu Met Ile Asp Cys Leu Val Ser Cys Phe 
    370                 375                 380                 


Arg Ile Ser Pro His Asn Asn Gln His Phe Lys Ile Cys Leu Ala Gln 
385                 390                 395                 400 


Asn Ser Pro Ser Thr Phe His Tyr Val Leu Val Asn Ser Leu His Arg 
                405                 410                 415     


Ile Ile Thr Asn Ser Ala Leu Asp Trp Trp Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Tyr Cys His Ser Val Glu Leu Arg Asn Met Phe Gly Glu Thr Leu His 
        435                 440                 445             


Lys Ala Val Gln Gly Cys Gly Ala His Pro Ala Ile Arg Met Ala Pro 
    450                 455                 460                 


Ser Leu Thr Phe Lys Glu Lys Val Thr Ser Leu Lys Phe Lys Glu Lys 
465                 470                 475                 480 


Pro Thr Asp Leu Glu Thr Arg Ser Tyr Lys Tyr Leu Leu Leu Ser Met 
                485                 490                 495     


Val Lys Leu Ile His Ala Asp Pro Lys Leu Leu Leu Cys Asn Pro Arg 
            500                 505                 510         


Lys Gln Gly Pro Glu Thr Gln Gly Ser Thr Ala Glu Leu Ile Thr Gly 
        515                 520                 525             


Leu Val Gln Leu Val Pro Gln Ser His Met Pro Glu Ile Ala Gln Glu 
    530                 535                 540                 


Ala Met Glu Ala Leu Leu Val Leu His Gln Leu Asp Ser Ile Asp Leu 
545                 550                 555                 560 


Trp Asn Pro Asp Ala Pro Val Glu Thr Phe Trp Glu Ile Ser Ser Gln 
                565                 570                 575     


Met Leu Phe Tyr Ile Cys Lys Lys Leu Thr Ser His Gln Met Leu Ser 
            580                 585                 590         


Ser Thr Glu Ile Leu Lys Trp Leu Arg Glu Ile Leu Ile Cys Arg Asn 
        595                 600                 605             


Lys Phe Leu Leu Lys Asn Lys Gln Ala Asp Arg Ser Ser Cys His Phe 
    610                 615                 620                 


Leu Leu Phe Tyr Gly Val Gly Cys Asp Ile Pro Ser Ser Gly Asn Thr 
625                 630                 635                 640 


Ser Gln Met Ser Met Asp His Glu Glu Leu Leu Arg Thr Pro Gly Ala 
                645                 650                 655     


Ser Leu Arg Lys Gly Lys Gly Asn Ser Ser Met Asp Ser Ala Ala Gly 
            660                 665                 670         


Cys Ser Gly Thr Pro Pro Ile Cys Arg Gln Ala Gln Thr Lys Leu Glu 
        675                 680                 685             


Val Ala Leu Tyr Met Phe Leu Trp Asn Pro Asp Thr Glu Ala Val Leu 
    690                 695                 700                 


Val Ala Met Ser Cys Phe Arg His Leu Cys Glu Glu Ala Asp Ile Arg 
705                 710                 715                 720 


Cys Gly Val Asp Glu Val Ser Val His Asn Leu Leu Pro Asn Tyr Asn 
                725                 730                 735     


Thr Phe Met Glu Phe Ala Ser Val Ser Asn Met Met Ser Thr Gly Arg 
            740                 745                 750         


Ala Ala Leu Gln Lys Arg Val Met Ala Leu Leu Arg Arg Ile Glu His 
        755                 760                 765             


Pro Thr Ala Gly Asn Thr Glu Ala Trp Glu Asp Thr His Ala Lys Trp 
    770                 775                 780                 


Glu Gln Ala Thr Lys Leu Ile Leu Asn Tyr Pro Lys Ala Lys Met Glu 
785                 790                 795                 800 


Asp Gly Gln Ala Ala Glu Ser Leu His Lys Thr Ile Val Lys Arg Arg 
                805                 810                 815     


Met Ser His Val Ser Gly Gly Gly Ser Ile Asp Leu Ser Asp Thr Asp 
            820                 825                 830         


Ser Leu Gln Glu Trp Ile Asn Met Thr Gly Phe Leu Cys Ala Leu Gly 
        835                 840                 845             


Gly Val Cys Leu Gln Gln Arg Ser Asn Ser Gly Leu Ala Thr Tyr Ser 
    850                 855                 860                 


Pro Pro Met Gly Pro Val Ser Glu Arg Lys Gly Ser Met Ile Ser Val 
865                 870                 875                 880 


Met Ser Ser Glu Gly Asn Ala Asp Thr Pro Val Ser Lys Phe Met Asp 
                885                 890                 895     


Arg Leu Leu Ser Leu Met Val Cys Asn His Glu Lys Val Gly Leu Gln 
            900                 905                 910         


Ile Arg Thr Asn Val Lys Asp Leu Val Gly Leu Glu Leu Ser Pro Ala 
        915                 920                 925             


Leu Tyr Pro Met Leu Phe Asn Lys Leu Lys Asn Thr Ile Ser Lys Phe 
    930                 935                 940                 


Phe Asp Ser Gln Gly Gln Val Leu Leu Thr Asp Thr Asn Thr Gln Phe 
945                 950                 955                 960 


Val Glu Gln Thr Ile Ala Ile Met Lys Asn Leu Leu Asp Asn His Thr 
                965                 970                 975     


Glu Gly Ser Ser Glu His Leu Gly Gln Ala Ser Ile Glu Thr Met Met 
            980                 985                 990         


Leu Asn Leu Val Arg Tyr Val Arg  Val Leu Gly Asn Met  Val His Ala 
        995                 1000                 1005             


Ile Gln  Ile Lys Thr Lys Leu  Cys Gln Leu Val Glu  Val Met Met 
    1010                 1015                 1020             


Ala Arg  Arg Asp Asp Leu Ser  Phe Cys Gln Glu Met  Lys Phe Arg 
    1025                 1030                 1035             


Asn Lys  Met Val Glu Tyr Leu  Thr Asp Trp Val Met  Gly Thr Ser 
    1040                 1045                 1050             


Asn Gln  Ala Ala Asp Asp Asp  Val Lys Cys Leu Thr  Arg Asp Leu 
    1055                 1060                 1065             


Asp Gln  Ala Ser Met Glu Ala  Val Val Ser Leu Leu  Ala Gly Leu 
    1070                 1075                 1080             


Pro Leu  Gln Pro Glu Glu Gly  Asp Gly Val Glu Leu  Met Glu Ala 
    1085                 1090                 1095             


Lys Ser  Gln Leu Phe Leu Lys  Tyr Phe Thr Leu Phe  Met Asn Leu 
    1100                 1105                 1110             


Leu Asn  Asp Cys Ser Glu Val  Glu Asp Glu Ser Ala  Gln Thr Gly 
    1115                 1120                 1125             


Gly Arg  Lys Arg Gly Met Ser  Arg Arg Leu Ala Ser  Leu Arg His 
    1130                 1135                 1140             


Cys Thr  Val Leu Ala Met Ser  Asn Leu Leu Asn Ala  Asn Val Asp 
    1145                 1150                 1155             


Ser Gly  Leu Met His Ser Ile  Gly Leu Gly Tyr His  Lys Asp Leu 
    1160                 1165                 1170             


Gln Thr  Arg Ala Thr Phe Met  Glu Val Leu Thr Lys  Ile Leu Gln 
    1175                 1180                 1185             


Gln Gly  Thr Glu Phe Asp Thr  Leu Ala Glu Thr Val  Leu Ala Asp 
    1190                 1195                 1200             


Arg Phe  Glu Arg Leu Val Glu  Leu Val Thr Met Met  Gly Asp Gln 
    1205                 1210                 1215             


Gly Glu  Leu Pro Ile Ala Met  Ala Leu Ala Asn Val  Val Pro Cys 
    1220                 1225                 1230             


Ser Gln  Trp Asp Glu Leu Ala  Arg Val Leu Val Thr  Leu Phe Asp 
    1235                 1240                 1245             


Ser Arg  His Leu Leu Tyr Gln  Leu Leu Trp Asn Met  Phe Ser Lys 
    1250                 1255                 1260             


Glu Val  Glu Leu Ala Asp Ser  Met Gln Thr Leu Phe  Arg Gly Asn 
    1265                 1270                 1275             


Ser Leu  Ala Ser Lys Ile Met  Thr Phe Cys Phe Lys  Val Tyr Gly 
    1280                 1285                 1290             


Ala Thr  Tyr Leu Gln Lys Leu  Leu Asp Pro Leu Leu  Arg Ile Val 
    1295                 1300                 1305             


Ile Thr  Ser Ser Asp Trp Gln  His Val Ser Phe Glu  Val Asp Pro 
    1310                 1315                 1320             


Thr Arg  Leu Glu Pro Ser Glu  Ser Leu Glu Glu Asn  Gln Arg Asn 
    1325                 1330                 1335             


Leu Leu  Gln Met Thr Glu Lys  Phe Phe His Ala Ile  Ile Ser Ser 
    1340                 1345                 1350             


Ser Ser  Glu Phe Pro Pro Gln  Leu Arg Ser Val Cys  His Cys Leu 
    1355                 1360                 1365             


Tyr Gln  Ala Thr Cys His Ser  Leu Leu Asn Lys Ala  Thr Val Lys 
    1370                 1375                 1380             


Glu Lys  Lys Glu Asn Lys Lys  Ser Val Val Ser Gln  Arg Phe Pro 
    1385                 1390                 1395             


Gln Asn  Ser Ile Gly Ala Val  Gly Ser Ala Met Phe  Leu Arg Phe 
    1400                 1405                 1410             


Ile Asn  Pro Ala Ile Val Ser  Pro Tyr Glu Ala Gly  Ile Leu Asp 
    1415                 1420                 1425             


Lys Lys  Pro Pro Pro Arg Ile  Glu Arg Gly Leu Lys  Leu Met Ser 
    1430                 1435                 1440             


Lys Ile  Leu Gln Ser Ile Ala  Asn His Val Leu Phe  Thr Lys Glu 
    1445                 1450                 1455             


Glu His  Met Arg Pro Phe Asn  Asp Phe Val Lys Ser  Asn Phe Asp 
    1460                 1465                 1470             


Ala Ala  Arg Arg Phe Phe Leu  Asp Ile Ala Ser Asp  Cys Pro Thr 
    1475                 1480                 1485             


Ser Asp  Ala Val Asn His Ser  Leu Ser Phe Ile Ser  Asp Gly Asn 
    1490                 1495                 1500             


Val Leu  Ala Leu His Arg Leu  Leu Trp Asn Asn Gln  Glu Lys Ile 
    1505                 1510                 1515             


Gly Gln  Tyr Leu Ser Ser Asn  Arg Asp His Lys Ala  Val Gly Arg 
    1520                 1525                 1530             


Arg Pro  Phe Asp Lys Met Ala  Thr Leu Leu Ala Tyr  Leu Gly Pro 
    1535                 1540                 1545             


Pro Glu  His Lys Pro Val Ala  Asp Thr His Trp Ser  Ser Leu Asn 
    1550                 1555                 1560             


Leu Thr  Ser Ser Lys Phe Glu  Glu Phe Met Thr Arg  His Gln Val 
    1565                 1570                 1575             


His Glu  Lys Glu Glu Phe Lys  Ala Leu Lys Thr Leu  Ser Ile Phe 
    1580                 1585                 1590             


Tyr Gln  Ala Gly Thr Ser Lys  Ala Gly Asn Pro Ile  Phe Tyr Tyr 
    1595                 1600                 1605             


Val Ala  Arg Arg Phe Lys Thr  Gly Gln Ile Asn Gly  Asp Leu Leu 
    1610                 1615                 1620             


Ile Tyr  His Val Leu Leu Thr  Leu Lys Pro Tyr Tyr  Ala Lys Pro 
    1625                 1630                 1635             


Tyr Glu  Ile Val Val Asp Leu  Thr His Thr Gly Pro  Ser Asn Arg 
    1640                 1645                 1650             


Phe Lys  Thr Asp Phe Leu Ser  Lys Trp Phe Val Val  Phe Pro Gly 
    1655                 1660                 1665             


Phe Ala  Tyr Asp Asn Val Ser  Ala Val Tyr Ile Tyr  Asn Cys Asn 
    1670                 1675                 1680             


Ser Trp  Val Arg Glu Tyr Thr  Lys Tyr His Glu Arg  Leu Leu Thr 
    1685                 1690                 1695             


Gly Leu  Lys Gly Ser Lys Arg  Leu Val Phe Ile Asp  Cys Pro Gly 
    1700                 1705                 1710             


Lys Leu  Ala Glu His Ile Glu  His Glu Gln Gln Lys  Leu Pro Ala 
    1715                 1720                 1725             


Ala Thr  Leu Ala Leu Glu Glu  Asp Leu Lys Val Phe  His Asn Ala 
    1730                 1735                 1740             


Leu Lys  Leu Ala His Lys Asp  Thr Lys Val Ser Ile  Lys Val Gly 
    1745                 1750                 1755             


Ser Thr  Ala Val Gln Val Thr  Ser Ala Glu Arg Thr  Lys Val Leu 
    1760                 1765                 1770             


Gly Gln  Ser Val Phe Leu Asn  Asp Ile Tyr Tyr Ala  Ser Glu Ile 
    1775                 1780                 1785             


Glu Glu  Ile Cys Leu Val Asp  Glu Asn Gln Phe Thr  Leu Thr Ile 
    1790                 1795                 1800             


Ala Asn  Gln Gly Thr Pro Leu  Thr Phe Met His Gln  Glu Cys Glu 
    1805                 1810                 1815             


Ala Ile  Val Gln Ser Ile Ile  His Ile Arg Thr Arg  Trp Glu Leu 
    1820                 1825                 1830             


Ser Gln  Pro Asp Ser Ile Pro  Gln His Thr Lys Ile  Arg Pro Lys 
    1835                 1840                 1845             


Asp Val  Pro Gly Thr Leu Leu  Asn Ile Ala Leu Leu  Asn Leu Gly 
    1850                 1855                 1860             


Ser Ser  Asp Pro Ser Leu Arg  Ser Ala Ala Tyr Asn  Leu Leu Cys 
    1865                 1870                 1875             


Ala Leu  Thr Cys Thr Phe Asn  Leu Lys Ile Glu Gly  Gln Leu Leu 
    1880                 1885                 1890             


Glu Thr  Ser Gly Leu Cys Ile  Pro Ala Asn Asn Thr  Leu Phe Ile 
    1895                 1900                 1905             


Val Ser  Ile Ser Lys Thr Leu  Ala Ala Asn Glu Pro  His Leu Thr 
    1910                 1915                 1920             


Leu Glu  Phe Leu Glu Glu Cys  Ile Ser Gly Phe Ser  Lys Ser Ser 
    1925                 1930                 1935             


Ile Glu  Leu Lys His Leu Cys  Leu Glu Tyr Met Thr  Pro Trp Leu 
    1940                 1945                 1950             


Ser Asn  Leu Val Arg Phe Cys  Lys His Asn Asp Asp  Ala Lys Arg 
    1955                 1960                 1965             


Gln Arg  Val Thr Ala Ile Leu  Asp Lys Leu Ile Thr  Met Thr Ile 
    1970                 1975                 1980             


Asn Glu  Lys Gln Met Tyr Pro  Ser Ile Gln Ala Lys  Ile Trp Gly 
    1985                 1990                 1995             


Ser Leu  Gly Gln Ile Thr Asp  Leu Leu Asp Val Val  Leu Asp Ser 
    2000                 2005                 2010             


Phe Ile  Lys Thr Ser Ala Thr  Gly Gly Leu Gly Ser  Ile Lys Ala 
    2015                 2020                 2025             


Glu Val  Met Ala Asp Thr Ala  Val Ala Leu Ala Ser  Gly Asn Val 
    2030                 2035                 2040             


Lys Leu  Val Ser Ser Lys Val  Ile Gly Arg Met Cys  Lys Ile Ile 
    2045                 2050                 2055             


Asp Lys  Thr Cys Leu Ser Pro  Thr Pro Thr Leu Glu  Gln His Leu 
    2060                 2065                 2070             


Met Trp  Asp Asp Ile Ala Ile  Leu Ala Arg Tyr Met  Leu Met Leu 
    2075                 2080                 2085             


Ser Phe  Asn Asn Ser Leu Asp  Val Ala Ala His Leu  Pro Tyr Leu 
    2090                 2095                 2100             


Phe His  Val Val Thr Phe Leu  Val Ala Thr Gly Pro  Leu Ser Leu 
    2105                 2110                 2115             


Arg Ala  Ser Thr His Gly Leu  Val Ile Asn Ile Ile  His Ser Leu 
    2120                 2125                 2130             


Cys Thr  Cys Ser Gln Leu His  Phe Ser Glu Glu Thr  Lys Gln Val 
    2135                 2140                 2145             


Leu Arg  Leu Ser Leu Thr Glu  Phe Ser Leu Pro Lys  Phe Tyr Leu 
    2150                 2155                 2160             


Leu Phe  Gly Ile Ser Lys Val  Lys Ser Ala Ala Val  Ile Ala Phe 
    2165                 2170                 2175             


Arg Ser  Ser Tyr Arg Asp Arg  Ser Phe Ser Pro Gly  Ser Tyr Glu 
    2180                 2185                 2190             


Arg Glu  Thr Phe Ala Leu Thr  Ser Leu Glu Thr Val  Thr Glu Ala 
    2195                 2200                 2205             


Leu Leu  Glu Ile Met Glu Ala  Cys Met Arg Asp Ile  Pro Thr Cys 
    2210                 2215                 2220             


Lys Trp  Leu Asp Gln Trp Thr  Glu Leu Ala Gln Arg  Phe Ala Phe 
    2225                 2230                 2235             


Gln Tyr  Asn Pro Ser Leu Gln  Pro Arg Ala Leu Val  Val Phe Gly 
    2240                 2245                 2250             


Cys Ile  Ser Lys Arg Val Ser  His Gly Gln Ile Lys  Gln Ile Ile 
    2255                 2260                 2265             


Arg Ile  Leu Ser Lys Ala Leu  Glu Ser Cys Leu Lys  Gly Pro Asp 
    2270                 2275                 2280             


Thr Tyr  Asn Ser Gln Val Leu  Ile Glu Ala Thr Val  Ile Ala Leu 
    2285                 2290                 2295             


Thr Lys  Leu Gln Pro Leu Leu  Asn Lys Asp Ser Pro  Leu His Lys 
    2300                 2305                 2310             


Ala Leu  Phe Trp Val Ala Val  Ala Val Leu Gln Leu  Asp Glu Val 
    2315                 2320                 2325             


Asn Leu  Tyr Ser Ala Gly Thr  Ala Leu Leu Glu Gln  Asn Leu His 
    2330                 2335                 2340             


Thr Leu  Asp Ser Leu Arg Ile  Phe Asn Asp Lys Ser  Pro Glu Glu 
    2345                 2350                 2355             


Val Phe  Met Ala Ile Arg Asn  Pro Leu Glu Trp His  Cys Lys Gln 
    2360                 2365                 2370             


Met Asp  His Phe Val Gly Leu  Asn Phe Asn Ser Asn  Phe Asn Phe 
    2375                 2380                 2385             


Ala Leu  Val Gly His Leu Leu  Lys Gly Tyr Arg His  Pro Ser Pro 
    2390                 2395                 2400             


Ala Ile  Val Ala Arg Thr Val  Arg Ile Leu His Thr  Leu Leu Thr 
    2405                 2410                 2415             


Leu Val  Asn Lys His Arg Asn  Cys Asp Lys Phe Glu  Val Asn Thr 
    2420                 2425                 2430             


Gln Ser  Val Ala Tyr Leu Ala  Ala Leu Leu Thr Val  Ser Glu Glu 
    2435                 2440                 2445             


Val Arg  Ser Arg Cys Ser Leu  Lys His Arg Lys Ser  Leu Leu Leu 
    2450                 2455                 2460             


Thr Asp  Ile Ser Met Glu Asn  Val Pro Met Asp Thr  Tyr Pro Ile 
    2465                 2470                 2475             


His His  Gly Asp Pro Ser Tyr  Arg Thr Leu Lys Glu  Thr Gln Pro 
    2480                 2485                 2490             


Trp Ser  Ser Pro Lys Gly Ser  Glu Gly Tyr Leu Ala  Ala Thr Tyr 
    2495                 2500                 2505             


Pro Thr  Val Gly Gln Thr Ser  Pro Arg Ala Arg Lys  Ser Met Ser 
    2510                 2515                 2520             


Leu Asp  Met Gly Gln Pro Ser  Gln Ala Asn Thr Lys  Lys Leu Leu 
    2525                 2530                 2535             


Gly Thr  Arg Lys Ser Phe Asp  His Leu Ile Ser Asp  Thr Lys Ala 
    2540                 2545                 2550             


Pro Lys  Arg Gln Glu Met Glu  Ser Gly Ile Thr Thr  Pro Pro Lys 
    2555                 2560                 2565             


Met Arg  Arg Val Ala Glu Thr  Asp Tyr Glu Met Glu  Thr Gln Arg 
    2570                 2575                 2580             


Ile Ser  Ser Ser Gln Gln His  Pro His Leu Arg Lys  Val Ser Val 
    2585                 2590                 2595             


Ser Glu  Ser Asn Val Leu Leu  Asp Glu Glu Val Leu  Thr Asp Pro 
    2600                 2605                 2610             


Lys Ile  Gln Ala Leu Leu Leu  Thr Val Leu Ala Thr  Leu Val Lys 
    2615                 2620                 2625             


Tyr Thr  Thr Asp Glu Phe Asp  Gln Arg Ile Leu Tyr  Glu Tyr Leu 
    2630                 2635                 2640             


Ala Glu  Ala Ser Val Val Phe  Pro Lys Val Phe Pro  Val Val His 
    2645                 2650                 2655             


Asn Leu  Leu Asp Ser Lys Ile  Asn Thr Leu Leu Ser  Leu Cys Gln 
    2660                 2665                 2670             


Asp Pro  Asn Leu Leu Asn Pro  Ile His Gly Ile Val  Gln Ser Val 
    2675                 2680                 2685             


Val Tyr  His Glu Glu Ser Pro  Pro Gln Tyr Gln Thr  Ser Tyr Leu 
    2690                 2695                 2700             


Gln Ser  Phe Gly Phe Asn Gly  Leu Trp Arg Phe Ala  Gly Pro Phe 
    2705                 2710                 2715             


Ser Lys  Gln Thr Gln Ile Pro  Asp Tyr Ala Glu Leu  Ile Val Lys 
    2720                 2725                 2730             


Phe Leu  Asp Ala Leu Ile Asp  Thr Tyr Leu Pro Gly  Ile Asp Glu 
    2735                 2740                 2745             


Glu Thr  Ser Glu Glu Ser Leu  Leu Thr Pro Thr Ser  Pro Tyr Pro 
    2750                 2755                 2760             


Pro Ala  Leu Gln Ser Gln Leu  Ser Ile Thr Ala Asn  Leu Asn Leu 
    2765                 2770                 2775             


Ser Asn  Ser Met Thr Ser Leu  Ala Thr Ser Gln His  Ser Pro Gly 
    2780                 2785                 2790             


Ile Asp  Lys Glu Asn Val Glu  Leu Ser Pro Thr Thr  Gly His Cys 
    2795                 2800                 2805             


Asn Ser  Gly Arg Thr Arg His  Gly Ser Ala Ser Gln  Val Gln Lys 
    2810                 2815                 2820             


Gln Arg  Ser Ala Gly Ser Phe  Lys Arg Asn Ser Ile  Lys Lys Ile 
    2825                 2830                 2835             


Val 
    


<210>  3
<211>  335
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Glyceraldehyde-3 phosphate dehydrogenase (GAPDH)

<400>  3

Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Arg Ile Gly Arg 
1               5                   10                  15      


Leu Val Thr Arg Ala Ala Phe Asn Ser Gly Lys Val Asp Ile Val Ala 
            20                  25                  30          


Ile Asn Asp Pro Phe Ile Asp Leu Asn Tyr Met Val Tyr Met Phe Gln 
        35                  40                  45              


Tyr Asp Ser Thr His Gly Lys Phe His Gly Thr Val Lys Ala Glu Asn 
    50                  55                  60                  


Gly Lys Leu Val Ile Asn Gly Asn Pro Ile Thr Ile Phe Gln Glu Arg 
65                  70                  75                  80  


Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala Gly Ala Glu Tyr Val Val 
                85                  90                  95      


Glu Ser Thr Gly Val Phe Thr Thr Met Glu Lys Ala Gly Ala His Leu 
            100                 105                 110         


Gln Gly Gly Ala Lys Arg Val Ile Ile Ser Ala Pro Ser Ala Asp Ala 
        115                 120                 125             


Pro Met Phe Val Met Gly Val Asn His Glu Lys Tyr Asp Asn Ser Leu 
    130                 135                 140                 


Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu 
145                 150                 155                 160 


Ala Lys Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met Thr 
                165                 170                 175     


Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser 
            180                 185                 190         


Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala Leu Gln Asn Ile Ile Pro 
        195                 200                 205             


Ala Ser Thr Gly Ala Ala Lys Ala Val Gly Lys Val Ile Pro Glu Leu 
    210                 215                 220                 


Asn Gly Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Ala Asn Val 
225                 230                 235                 240 


Ser Val Val Asp Leu Thr Cys Arg Leu Glu Lys Pro Ala Lys Tyr Asp 
                245                 250                 255     


Asp Ile Lys Lys Val Val Lys Gln Ala Ser Glu Gly Pro Leu Lys Gly 
            260                 265                 270         


Ile Leu Gly Tyr Thr Glu His Gln Val Val Ser Ser Asp Phe Asn Ser 
        275                 280                 285             


Asp Thr His Ser Ser Thr Phe Asp Ala Gly Ala Gly Ile Ala Leu Asn 
    290                 295                 300                 


Asp His Phe Val Lys Leu Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr 
305                 310                 315                 320 


Ser Asn Arg Val Val Asp Leu Met Ala His Met Ala Ser Lys Glu 
                325                 330                 335 


<210>  4
<211>  1894
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Protein 1 containing fibronectin domain type III

<220>
<221>  misc_feature
<223>  or Fibronectin Type III Domain Containing  protein 1 (FNDC1)

<400>  4

Met Ala Pro Glu Ala Gly Ala Thr Leu Arg Ala Pro Arg Arg Leu Ser 
1               5                   10                  15      


Trp Ala Ala Leu Leu Leu Leu Ala Ala Leu Leu Pro Val Ala Ser Ser 
            20                  25                  30          


Ala Ala Ala Ser Val Asp His Pro Leu Lys Pro Arg His Val Lys Leu 
        35                  40                  45              


Leu Ser Thr Lys Met Gly Leu Lys Val Thr Trp Asp Pro Pro Lys Asp 
    50                  55                  60                  


Ala Thr Ser Arg Pro Val Glu His Tyr Asn Ile Ala Tyr Gly Lys Ser 
65                  70                  75                  80  


Leu Lys Ser Leu Lys Tyr Ile Lys Val Asn Ala Glu Thr Tyr Ser Phe 
                85                  90                  95      


Leu Ile Glu Asp Val Glu Pro Gly Val Val Tyr Phe Val Leu Leu Thr 
            100                 105                 110         


Ala Glu Asn His Ser Gly Val Ser Arg Pro Val Tyr Arg Ala Glu Ser 
        115                 120                 125             


Pro Pro Gly Gly Glu Trp Ile Glu Ile Asp Gly Phe Pro Ile Lys Gly 
    130                 135                 140                 


Pro Gly Pro Phe Asn Glu Thr Val Thr Glu Lys Glu Val Pro Asn Lys 
145                 150                 155                 160 


Pro Leu Arg Val Arg Val Arg Ser Ser Asp Asp Arg Leu Ser Val Ala 
                165                 170                 175     


Trp Lys Ala Pro Arg Leu Ser Gly Ala Lys Ser Pro Arg Arg Ser Arg 
            180                 185                 190         


Gly Phe Leu Leu Gly Tyr Gly Glu Ser Gly Arg Lys Met Asn Tyr Val 
        195                 200                 205             


Pro Leu Thr Arg Asp Glu Arg Thr His Glu Ile Lys Lys Leu Ala Ser 
    210                 215                 220                 


Glu Ser Val Tyr Val Val Ser Leu Gln Ser Met Asn Ser Gln Gly Arg 
225                 230                 235                 240 


Ser Gln Pro Val Tyr Arg Ala Ala Leu Thr Lys Arg Lys Ile Ser Glu 
                245                 250                 255     


Glu Asp Glu Leu Asp Val Pro Asp Asp Ile Ser Val Arg Val Met Ser 
            260                 265                 270         


Ser Gln Ser Val Leu Val Ser Trp Val Asp Pro Val Leu Glu Lys Gln 
        275                 280                 285             


Lys Lys Val Val Ala Ser Arg Gln Tyr Thr Val Arg Tyr Arg Glu Lys 
    290                 295                 300                 


Gly Glu Leu Ala Arg Trp Asp Tyr Lys Gln Ile Ala Asn Arg Arg Val 
305                 310                 315                 320 


Leu Ile Glu Asn Leu Ile Pro Asp Thr Val Tyr Glu Phe Ala Val Arg 
                325                 330                 335     


Ile Ser Gln Gly Glu Arg Asp Gly Lys Trp Ser Thr Ser Val Phe Gln 
            340                 345                 350         


Arg Thr Pro Glu Ser Ala Pro Thr Thr Ala Pro Glu Asn Leu Asn Val 
        355                 360                 365             


Trp Pro Val Asn Gly Lys Pro Thr Val Val Ala Ala Ser Trp Asp Ala 
    370                 375                 380                 


Leu Pro Glu Thr Glu Gly Lys Val Lys Glu Tyr Ile Leu Ser Tyr Ala 
385                 390                 395                 400 


Pro Ala Leu Lys Pro Phe Gly Ala Lys Ser Leu Thr Tyr Pro Gly Asp 
                405                 410                 415     


Thr Thr Ser Ala Leu Val Asp Gly Leu Gln Pro Gly Glu Arg Tyr Leu 
            420                 425                 430         


Phe Lys Ile Arg Ala Thr Asn Arg Arg Gly Leu Gly Pro His Ser Lys 
        435                 440                 445             


Ala Phe Ile Val Ala Met Pro Thr Thr Ser Lys Ala Asp Val Glu Gln 
    450                 455                 460                 


Asn Thr Glu Asp Asn Gly Lys Pro Glu Lys Pro Glu Pro Ser Ser Pro 
465                 470                 475                 480 


Ser Pro Arg Ala Pro Ala Ser Ser Gln His Pro Ser Val Pro Ala Ser 
                485                 490                 495     


Pro Gln Gly Arg Asn Ala Lys Asp Leu Leu Leu Asp Leu Lys Asn Lys 
            500                 505                 510         


Ile Leu Ala Asn Gly Gly Ala Pro Arg Lys Pro Gln Leu Arg Ala Lys 
        515                 520                 525             


Lys Ala Glu Glu Leu Asp Leu Gln Ser Thr Glu Ile Thr Gly Glu Glu 
    530                 535                 540                 


Glu Leu Gly Ser Arg Glu Asp Ser Pro Met Ser Pro Ser Asp Thr Gln 
545                 550                 555                 560 


Asp Gln Lys Arg Thr Leu Arg Pro Pro Ser Arg His Gly His Ser Val 
                565                 570                 575     


Val Ala Pro Gly Arg Thr Ala Val Arg Ala Arg Met Pro Ala Leu Pro 
            580                 585                 590         


Arg Arg Glu Gly Val Asp Lys Pro Gly Phe Ser Leu Ala Thr Gln Pro 
        595                 600                 605             


Arg Pro Gly Ala Pro Pro Ser Ala Ser Ala Ser Pro Ala His His Ala 
    610                 615                 620                 


Ser Thr Gln Gly Thr Ser His Arg Pro Ser Leu Pro Ala Ser Leu Asn 
625                 630                 635                 640 


Asp Asn Asp Leu Val Asp Ser Asp Glu Asp Glu Arg Ala Val Gly Ser 
                645                 650                 655     


Leu His Pro Lys Gly Ala Phe Ala Gln Pro Arg Pro Ala Leu Ser Pro 
            660                 665                 670         


Ser Arg Gln Ser Pro Ser Ser Val Leu Arg Asp Arg Ser Ser Val His 
        675                 680                 685             


Pro Gly Ala Lys Pro Ala Ser Pro Ala Arg Arg Thr Pro His Ser Gly 
    690                 695                 700                 


Ala Ala Glu Glu Asp Ser Ser Ala Ser Ala Pro Pro Ser Arg Leu Ser 
705                 710                 715                 720 


Pro Pro His Gly Gly Ser Ser Arg Leu Leu Pro Thr Gln Pro His Leu 
                725                 730                 735     


Ser Ser Pro Leu Ser Lys Gly Gly Lys Asp Gly Glu Asp Ala Pro Ala 
            740                 745                 750         


Thr Asn Ser Asn Ala Pro Ser Arg Ser Thr Met Ser Ser Ser Val Ser 
        755                 760                 765             


Ser His Leu Ser Ser Arg Thr Gln Val Ser Glu Gly Ala Glu Ala Ser 
    770                 775                 780                 


Asp Gly Glu Ser His Gly Asp Gly Asp Arg Glu Asp Gly Gly Arg Gln 
785                 790                 795                 800 


Ala Glu Ala Thr Ala Gln Thr Leu Arg Ala Arg Pro Ala Ser Gly His 
                805                 810                 815     


Phe His Leu Leu Arg His Lys Pro Phe Ala Ala Asn Gly Arg Ser Pro 
            820                 825                 830         


Ser Arg Phe Ser Ile Gly Arg Gly Pro Arg Leu Gln Pro Ser Ser Ser 
        835                 840                 845             


Pro Gln Ser Thr Val Pro Ser Arg Ala His Pro Arg Val Pro Ser His 
    850                 855                 860                 


Ser Asp Ser His Pro Lys Leu Ser Ser Gly Ile His Gly Asp Glu Glu 
865                 870                 875                 880 


Asp Glu Lys Pro Leu Pro Ala Thr Val Val Asn Asp His Val Pro Ser 
                885                 890                 895     


Ser Ser Arg Gln Pro Ile Ser Arg Gly Trp Glu Asp Leu Arg Arg Ser 
            900                 905                 910         


Pro Gln Arg Gly Ala Ser Leu His Arg Lys Glu Pro Ile Pro Glu Asn 
        915                 920                 925             


Pro Lys Ser Thr Gly Ala Asp Thr His Pro Gln Gly Lys Tyr Ser Ser 
    930                 935                 940                 


Leu Ala Ser Lys Ala Gln Asp Val Gln Gln Ser Thr Asp Ala Asp Thr 
945                 950                 955                 960 


Glu Gly His Ser Pro Lys Ala Gln Pro Gly Ser Thr Asp Arg His Ala 
                965                 970                 975     


Ser Pro Ala Arg Pro Pro Ala Ala Arg Ser Gln Gln His Pro Ser Val 
            980                 985                 990         


Pro Arg Arg Met Thr Pro Gly Arg  Ala Pro Gln Gln Gln  Pro Pro Pro 
        995                 1000                 1005             


Pro Val  Ala Thr Ser Gln His  His Pro Gly Pro Gln  Ser Arg Asp 
    1010                 1015                 1020             


Ala Gly  Arg Ser Pro Ser Gln  Pro Arg Leu Ser Leu  Thr Gln Ala 
    1025                 1030                 1035             


Gly Arg  Pro Arg Pro Thr Ser  Gln Gly Arg Ser His  Ser Ser Ser 
    1040                 1045                 1050             


Asp Pro  Tyr Thr Ala Ser Ser  Arg Gly Met Leu Pro  Thr Ala Leu 
    1055                 1060                 1065             


Gln Asn  Gln Asp Glu Asp Ala  Gln Gly Ser Tyr Asp  Asp Asp Ser 
    1070                 1075                 1080             


Thr Glu  Val Glu Ala Gln Asp  Val Arg Ala Pro Ala  His Ala Ala 
    1085                 1090                 1095             


Arg Ala  Lys Glu Ala Ala Ala  Ser Leu Pro Lys His  Gln Gln Val 
    1100                 1105                 1110             


Glu Ser  Pro Thr Gly Ala Gly  Ala Gly Gly Asp His  Arg Ser Gln 
    1115                 1120                 1125             


Arg Gly  His Ala Ala Ser Pro  Ala Arg Pro Ser Arg  Pro Gly Gly 
    1130                 1135                 1140             


Pro Gln  Ser Arg Ala Arg Val  Pro Ser Arg Ala Ala  Pro Gly Lys 
    1145                 1150                 1155             


Ser Glu  Pro Pro Ser Lys Arg  Pro Leu Ser Ser Lys  Ser Gln Gln 
    1160                 1165                 1170             


Ser Val  Ser Ala Glu Asp Asp  Glu Glu Glu Asp Ala  Gly Phe Phe 
    1175                 1180                 1185             


Lys Gly  Gly Lys Glu Asp Leu  Leu Ser Ser Ser Val  Pro Lys Trp 
    1190                 1195                 1200             


Pro Ser  Ser Ser Thr Pro Arg  Gly Gly Lys Asp Ala  Asp Gly Ser 
    1205                 1210                 1215             


Leu Ala  Lys Glu Glu Arg Glu  Pro Ala Ile Ala Leu  Ala Pro Arg 
    1220                 1225                 1230             


Gly Gly  Ser Leu Ala Pro Val  Lys Arg Pro Leu Pro  Pro Pro Pro 
    1235                 1240                 1245             


Gly Ser  Ser Pro Arg Ala Ser  His Val Pro Ser Arg  Leu Pro Pro 
    1250                 1255                 1260             


Arg Ser  Ala Ala Thr Val Ser  Pro Val Ala Gly Thr  His Pro Trp 
    1265                 1270                 1275             


Pro Gln  Tyr Thr Thr Arg Ala  Pro Pro Gly His Phe  Ser Thr Thr 
    1280                 1285                 1290             


Pro Met  Leu Ser Leu Arg Gln  Arg Met Met His Ala  Arg Phe Arg 
    1295                 1300                 1305             


Asn Pro  Leu Ser Arg Gln Pro  Ala Arg Pro Ser Tyr  Arg Gln Gly 
    1310                 1315                 1320             


Tyr Asn  Gly Arg Pro Asn Val  Glu Gly Lys Val Leu  Pro Gly Ser 
    1325                 1330                 1335             


Asn Gly  Lys Pro Asn Gly Gln  Arg Ile Ile Asn Gly  Pro Gln Gly 
    1340                 1345                 1350             


Thr Lys  Trp Val Val Asp Leu  Asp Arg Gly Leu Val  Leu Asn Ala 
    1355                 1360                 1365             


Glu Gly  Arg Tyr Leu Gln Asp  Ser His Gly Asn Pro  Leu Arg Ile 
    1370                 1375                 1380             


Lys Leu  Gly Gly Asp Gly Arg  Thr Ile Val Asp Leu  Glu Gly Thr 
    1385                 1390                 1395             


Pro Val  Val Ser Pro Asp Gly  Leu Pro Leu Phe Gly  Gln Gly Arg 
    1400                 1405                 1410             


His Gly  Thr Pro Leu Ala Asn  Ala Gln Asp Lys Pro  Ile Leu Ser 
    1415                 1420                 1425             


Leu Gly  Gly Lys Pro Leu Val  Gly Leu Glu Val Ile  Lys Lys Thr 
    1430                 1435                 1440             


Thr His  Pro Pro Thr Thr Thr  Met Gln Pro Thr Thr  Thr Thr Thr 
    1445                 1450                 1455             


Pro Leu  Pro Thr Thr Thr Thr  Pro Arg Pro Thr Thr  Ala Thr Thr 
    1460                 1465                 1470             


Arg Arg  Thr Thr Thr Thr Arg  Arg Thr Thr Thr Arg  Arg Pro Thr 
    1475                 1480                 1485             


Thr Thr  Val Arg Thr Thr Thr  Arg Thr Thr Thr Thr  Thr Thr Pro 
    1490                 1495                 1500             


Thr Pro  Thr Thr Pro Ile Pro  Thr Cys Pro Pro Gly  Thr Leu Glu 
    1505                 1510                 1515             


Arg His  Asp Asp Asp Gly Asn  Leu Ile Met Ser Ser  Asn Gly Ile 
    1520                 1525                 1530             


Pro Glu  Cys Tyr Ala Glu Glu  Asp Glu Phe Ser Gly  Leu Glu Thr 
    1535                 1540                 1545             


Asp Thr  Ala Val Pro Thr Glu  Glu Ala Tyr Val Ile  Tyr Asp Glu 
    1550                 1555                 1560             


Asp Tyr  Glu Phe Glu Thr Ser  Arg Pro Pro Thr Thr  Thr Glu Pro 
    1565                 1570                 1575             


Ser Thr  Thr Ala Thr Thr Pro  Arg Val Ile Pro Glu  Glu Gly Ala 
    1580                 1585                 1590             


Ile Ser  Ser Phe Pro Glu Glu  Glu Phe Asp Leu Ala  Gly Arg Lys 
    1595                 1600                 1605             


Arg Phe  Val Ala Pro Tyr Val  Thr Tyr Leu Asn Lys  Asp Pro Ser 
    1610                 1615                 1620             


Ala Pro  Cys Ser Leu Thr Asp  Ala Leu Asp His Phe  Gln Val Asp 
    1625                 1630                 1635             


Ser Leu  Asp Glu Ile Ile Pro  Asn Asp Leu Lys Lys  Ser Asp Leu 
    1640                 1645                 1650             


Pro Pro  Gln His Ala Pro Arg  Asn Ile Thr Val Val  Ala Val Glu 
    1655                 1660                 1665             


Gly Cys  His Ser Phe Val Ile  Val Asp Trp Asp Lys  Ala Thr Pro 
    1670                 1675                 1680             


Gly Asp  Val Val Thr Gly Tyr  Leu Val Tyr Ser Ala  Ser Tyr Glu 
    1685                 1690                 1695             


Asp Phe  Ile Arg Asn Lys Trp  Ser Thr Gln Ala Ser  Ser Val Thr 
    1700                 1705                 1710             


His Leu  Pro Ile Glu Asn Leu  Lys Pro Asn Thr Arg  Tyr Tyr Phe 
    1715                 1720                 1725             


Lys Val  Gln Ala Gln Asn Pro  His Gly Tyr Gly Pro  Ile Ser Pro 
    1730                 1735                 1740             


Ser Val  Ser Phe Val Thr Glu  Ser Asp Asn Pro Leu  Leu Val Val 
    1745                 1750                 1755             


Arg Pro  Pro Gly Gly Glu Pro  Ile Trp Ile Pro Phe  Ala Phe Lys 
    1760                 1765                 1770             


His Asp  Pro Ser Tyr Thr Asp  Cys His Gly Arg Gln  Tyr Val Lys 
    1775                 1780                 1785             


Arg Thr  Trp Tyr Arg Lys Phe  Val Gly Val Val Leu  Cys Asn Ser 
    1790                 1795                 1800             


Leu Arg  Tyr Lys Ile Tyr Leu  Ser Asp Asn Leu Lys  Asp Thr Phe 
    1805                 1810                 1815             


Tyr Ser  Ile Gly Asp Ser Trp  Gly Arg Gly Glu Asp  His Cys Gln 
    1820                 1825                 1830             


Phe Val  Asp Ser His Leu Asp  Gly Arg Thr Gly Pro  Gln Ser Tyr 
    1835                 1840                 1845             


Val Glu  Ala Leu Pro Thr Ile  Gln Gly Tyr Tyr Arg  Gln Tyr Arg 
    1850                 1855                 1860             


Gln Glu  Pro Val Arg Phe Gly  Asn Ile Gly Phe Gly  Thr Pro Tyr 
    1865                 1870                 1875             


Tyr Tyr  Val Gly Trp Tyr Glu  Cys Gly Val Ser Ile  Pro Gly Lys 
    1880                 1885                 1890             


Trp 
    


<210>  5
<211>  406
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Eukaryotic initiation factor 4A-I (EIF4A1)

<400>  5

Met Ser Ala Ser Gln Asp Ser Arg Ser Arg Asp Asn Gly Pro Asp Gly 
1               5                   10                  15      


Met Glu Pro Glu Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp 
            20                  25                  30          


Ser Phe Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr 
        35                  40                  45              


Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu 
    50                  55                  60                  


Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr 
65                  70                  75                  80  


Gly Lys Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu 
                85                  90                  95      


Asp Leu Lys Ala Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu 
            100                 105                 110         


Ala Gln Gln Ile Gln Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly 
        115                 120                 125             


Ala Ser Cys His Ala Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val 
    130                 135                 140                 


Gln Lys Leu Gln Met Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly 
145                 150                 155                 160 


Arg Val Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile 
                165                 170                 175     


Lys Met Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe 
            180                 185                 190         


Lys Asp Gln Ile Tyr Asp Ile Phe Gln Lys Leu Asn Ser Asn Thr Gln 
        195                 200                 205             


Val Val Leu Leu Ser Ala Thr Met Pro Ser Asp Val Leu Glu Val Thr 
    210                 215                 220                 


Lys Lys Phe Met Arg Asp Pro Ile Arg Ile Leu Val Lys Lys Glu Glu 
225                 230                 235                 240 


Leu Thr Leu Glu Gly Ile Arg Gln Phe Tyr Ile Asn Val Glu Arg Glu 
                245                 250                 255     


Glu Trp Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr Leu Thr Ile 
            260                 265                 270         


Thr Gln Ala Val Ile Phe Ile Asn Thr Arg Arg Lys Val Asp Trp Leu 
        275                 280                 285             


Thr Glu Lys Met His Ala Arg Asp Phe Thr Val Ser Ala Met His Gly 
    290                 295                 300                 


Asp Met Asp Gln Lys Glu Arg Asp Val Ile Met Arg Glu Phe Arg Ser 
305                 310                 315                 320 


Gly Ser Ser Arg Val Leu Ile Thr Thr Asp Leu Leu Ala Arg Gly Ile 
                325                 330                 335     


Asp Val Gln Gln Val Ser Leu Val Ile Asn Tyr Asp Leu Pro Thr Asn 
            340                 345                 350         


Arg Glu Asn Tyr Ile His Arg Ile Gly Arg Gly Gly Arg Phe Gly Arg 
        355                 360                 365             


Lys Gly Val Ala Ile Asn Met Val Thr Glu Glu Asp Lys Arg Thr Leu 
    370                 375                 380                 


Arg Asp Ile Glu Thr Phe Tyr Asn Thr Ser Ile Glu Glu Met Pro Leu 
385                 390                 395                 400 


Asn Val Ala Asp Leu Ile 
                405     


<210>  6
<211>  334
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  L-lactate dehydrogenase chain B (LDHB)

<400>  6

Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu 
1               5                   10                  15      


Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val 
            20                  25                  30          


Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu 
        35                  40                  45              


Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met 
    50                  55                  60                  


Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala 
65                  70                  75                  80  


Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr 
                85                  90                  95      


Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln 
            100                 105                 110         


Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr 
        115                 120                 125             


Ser Pro Asp Cys Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu 
    130                 135                 140                 


Thr Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile 
145                 150                 155                 160 


Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala 
                165                 170                 175     


Glu Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly 
            180                 185                 190         


Glu His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala 
        195                 200                 205             


Gly Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp 
    210                 215                 220                 


Ser Glu Asn Trp Lys Glu Val His Lys Met Val Val Glu Ser Ala Tyr 
225                 230                 235                 240 


Glu Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser 
                245                 250                 255     


Val Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His 
            260                 265                 270         


Pro Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val 
        275                 280                 285             


Phe Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val 
    290                 295                 300                 


Ile Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser 
305                 310                 315                 320 


Ala Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu 
                325                 330                 


<210>  7
<211>  372
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Nuclear heterogeneous Ribonucleoprotein A1 (HNRNPA1)

<400>  7

Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Gly Tyr Gly Gly Gly 
                245                 250                 255     


Gly Pro Gly Tyr Ser Gly Gly Ser Arg Gly Tyr Gly Ser Gly Gly Gln 
            260                 265                 270         


Gly Tyr Gly Asn Gln Gly Ser Gly Tyr Gly Gly Ser Gly Ser Tyr Asp 
        275                 280                 285             


Ser Tyr Asn Asn Gly Gly Gly Gly Gly Phe Gly Gly Gly Ser Gly Ser 
    290                 295                 300                 


Asn Phe Gly Gly Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn 
305                 310                 315                 320 


Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg 
                325                 330                 335     


Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg 
            340                 345                 350         


Asn Gln Gly Gly Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser 
        355                 360                 365             


Gly Arg Arg Phe 
    370         


<210>  8
<211>  2849
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Polycystic kidney disease protein 1-like 1 (PKD1L1)

<400>  8

Met Ala Glu Glu Ala Ala Gln Asn Ile Ser Asp Asp Gln Glu Arg Cys 
1               5                   10                  15      


Leu Gln Ala Ala Cys Cys Leu Ser Phe Gly Gly Glu Leu Ser Val Ser 
            20                  25                  30          


Thr Asp Lys Ser Trp Gly Leu His Leu Cys Ser Cys Ser Pro Pro Gly 
        35                  40                  45              


Gly Gly Leu Trp Val Glu Val Tyr Ala Asn His Val Leu Leu Met Ser 
    50                  55                  60                  


Asp Gly Lys Cys Gly Cys Pro Trp Cys Ala Leu Asn Gly Lys Ala Glu 
65                  70                  75                  80  


Asp Arg Glu Ser Gln Ser Pro Ser Ser Ser Ala Ser Arg Gln Lys Asn 
                85                  90                  95      


Ile Trp Lys Thr Thr Ser Glu Ala Ala Leu Ser Val Val Asn Glu Lys 
            100                 105                 110         


Thr Gln Ala Val Val Asn Glu Lys Thr Gln Ala Pro Leu Asp Cys Asp 
        115                 120                 125             


Asn Ser Ala Asp Arg Ile Pro His Lys Pro Phe Ile Ile Ile Ala Arg 
    130                 135                 140                 


Ala Trp Ser Ser Gly Gly Pro Arg Phe His His Arg Arg Leu Cys Ala 
145                 150                 155                 160 


Thr Gly Thr Ala Asp Ser Thr Phe Ser Ala Leu Leu Gln Leu Gln Gly 
                165                 170                 175     


Thr Thr Ser Ala Ala Ala Pro Cys Ser Leu Lys Met Glu Ala Ser Cys 
            180                 185                 190         


Cys Val Leu Arg Leu Leu Cys Cys Ala Glu Asp Val Ala Thr Gly Leu 
        195                 200                 205             


Leu Pro Gly Thr Val Thr Met Glu Thr Pro Thr Lys Val Ala Arg Pro 
    210                 215                 220                 


Thr Gln Thr Ser Ser Gln Arg Val Pro Leu Trp Pro Ile Ser His Phe 
225                 230                 235                 240 


Pro Thr Ser Pro Arg Ser Ser His Gly Leu Pro Pro Gly Ile Pro Arg 
                245                 250                 255     


Thr Pro Ser Phe Thr Ala Ser Gln Ser Gly Ser Glu Ile Leu Tyr Pro 
            260                 265                 270         


Pro Thr Gln His Pro Pro Val Ala Ile Leu Ala Arg Asn Ser Asp Asn 
        275                 280                 285             


Phe Met Asn Pro Val Leu Asn Cys Ser Leu Glu Val Glu Ala Arg Ala 
    290                 295                 300                 


Pro Pro Asn Leu Gly Phe Arg Val His Met Ala Ser Gly Glu Ala Leu 
305                 310                 315                 320 


Cys Leu Met Met Asp Phe Gly Asp Ser Ser Gly Val Glu Met Arg Leu 
                325                 330                 335     


His Asn Met Ser Glu Ala Met Ala Val Thr Ala Tyr His Gln Tyr Ser 
            340                 345                 350         


Lys Gly Ile Phe Phe His Leu Leu His Phe Gln Leu Asp Met Ser Thr 
        355                 360                 365             


Tyr Lys Glu Ala Glu Thr Gln Asn Thr Thr Leu Asn Val Tyr Leu Cys 
    370                 375                 380                 


Gln Ser Glu Asn Ser Cys Leu Glu Asp Ser Asp Pro Ser Asn Leu Gly 
385                 390                 395                 400 


Tyr Glu Leu Ile Ser Ala Phe Val Thr Lys Gly Val Tyr Met Leu Lys 
                405                 410                 415     


Ala Val Ile Tyr Asn Glu Phe His Gly Thr Glu Val Glu Leu Gly Pro 
            420                 425                 430         


Tyr Tyr Val Glu Ile Gly His Glu Ala Val Ser Ala Phe Met Asn Ser 
        435                 440                 445             


Ser Ser Val His Glu Asp Glu Val Leu Val Phe Ala Asp Ser Gln Val 
    450                 455                 460                 


Asn Gln Lys Ser Thr Val Val Ile His His Phe Pro Ser Ile Pro Ser 
465                 470                 475                 480 


Tyr Asn Val Ser Phe Ile Ser Gln Thr Gln Val Gly Asp Ser Gln Ala 
                485                 490                 495     


Trp His Ser Met Thr Val Trp Tyr Lys Met Gln Ser Val Ser Val Tyr 
            500                 505                 510         


Thr Asn Gly Thr Val Phe Ala Thr Asp Thr Asp Ile Thr Phe Thr Ala 
        515                 520                 525             


Val Thr Lys Glu Thr Ile Pro Leu Glu Phe Glu Trp Tyr Phe Gly Glu 
    530                 535                 540                 


Asp Pro Pro Val Arg Thr Thr Ser Arg Ser Ile Lys Lys Arg Leu Ser 
545                 550                 555                 560 


Ile Pro Gln Trp Tyr Arg Val Met Val Lys Ala Ser Asn Arg Met Ser 
                565                 570                 575     


Ser Val Val Ser Glu Pro His Val Ile Arg Val Gln Lys Lys Ile Val 
            580                 585                 590         


Ala Asn Arg Leu Thr Ser Pro Ser Ser Ala Leu Val Asn Ala Ser Val 
        595                 600                 605             


Ala Phe Glu Cys Trp Ile Asn Phe Gly Thr Asp Val Ala Tyr Leu Trp 
    610                 615                 620                 


Asp Phe Gly Asp Gly Thr Val Ser Leu Gly Ser Ser Ser Ser Ser His 
625                 630                 635                 640 


Val Tyr Ser Arg Glu Gly Glu Phe Thr Val Glu Val Leu Ala Phe Asn 
                645                 650                 655     


Asn Val Ser Ala Ser Thr Leu Arg Gln Gln Leu Phe Ile Val Cys Glu 
            660                 665                 670         


Pro Cys Gln Pro Pro Leu Val Lys Asn Met Gly Pro Gly Lys Val Gln 
        675                 680                 685             


Ile Trp Arg Ser Gln Pro Val Arg Leu Gly Val Thr Phe Glu Ala Ala 
    690                 695                 700                 


Val Phe Cys Asp Ile Ser Gln Gly Leu Ser Tyr Thr Trp Asn Leu Met 
705                 710                 715                 720 


Asp Ser Glu Gly Leu Pro Val Ser Leu Pro Ala Ala Val Asp Thr His 
                725                 730                 735     


Arg Gln Thr Leu Ile Leu Pro Ser His Thr Leu Glu Tyr Gly Asn Tyr 
            740                 745                 750         


Thr Ala Leu Ala Lys Val Gln Ile Glu Gly Ser Val Val Tyr Ser Asn 
        755                 760                 765             


Tyr Cys Val Gly Leu Glu Val Arg Ala Gln Ala Pro Val Ser Val Ile 
    770                 775                 780                 


Ser Glu Gly Thr His Leu Phe Phe Ser Arg Thr Thr Ser Ser Pro Ile 
785                 790                 795                 800 


Val Leu Arg Gly Thr Gln Ser Phe Asp Pro Asp Asp Pro Gly Ala Thr 
                805                 810                 815     


Leu Arg Tyr His Trp Glu Cys Ala Thr Ala Gly Ser Pro Ala His Pro 
            820                 825                 830         


Cys Phe Asp Ser Ser Thr Ala His Gln Leu Asp Ala Ala Ala Pro Thr 
        835                 840                 845             


Val Ser Phe Glu Ala Gln Trp Leu Ser Asp Ser Tyr Asp Gln Phe Leu 
    850                 855                 860                 


Val Met Leu Arg Val Ser Ser Gly Gly Arg Asn Ser Ser Glu Thr Arg 
865                 870                 875                 880 


Val Phe Leu Ser Pro Tyr Pro Asp Ser Ala Phe Arg Phe Val His Ile 
                885                 890                 895     


Ser Trp Val Ser Phe Lys Asp Thr Phe Val Asn Trp Asn Asp Glu Leu 
            900                 905                 910         


Ser Leu Gln Ala Met Cys Glu Asp Cys Ser Glu Ile Pro Asn Leu Ser 
        915                 920                 925             


Tyr Ser Trp Asp Leu Phe Leu Val Asn Ala Thr Glu Lys Asn Arg Ile 
    930                 935                 940                 


Glu Val Pro Phe Cys Arg Val Val Gly Leu Leu Gly Ser Leu Gly Leu 
945                 950                 955                 960 


Gly Ala Ile Ser Glu Ser Ser Gln Leu Asn Leu Leu Pro Thr Glu Pro 
                965                 970                 975     


Gly Thr Ala Asp Pro Asp Ala Thr Thr Thr Pro Phe Ser Arg Glu Pro 
            980                 985                 990         


Ser Pro Val Thr Leu Gly Gln Pro  Ala Thr Ser Ala Pro  Arg Gly Thr 
        995                 1000                 1005             


Pro Thr  Glu Pro Met Thr Gly  Val Tyr Trp Ile Pro  Pro Ala Gly 
    1010                 1015                 1020             


Asp Ser  Ala Val Leu Gly Glu  Ala Pro Glu Glu Gly  Ser Leu Asp 
    1025                 1030                 1035             


Leu Glu  Pro Gly Pro Gln Ser  Lys Gly Ser Leu Met  Thr Gly Arg 
    1040                 1045                 1050             


Ser Glu  Arg Ser Gln Pro Thr  His Ser Pro Asp Pro  His Leu Ser 
    1055                 1060                 1065             


Asp Phe  Glu Ala Tyr Tyr Ser  Asp Ile Gln Glu Ala  Ile Pro Ser 
    1070                 1075                 1080             


Gly Gly  Arg Gln Pro Ala Lys  Asp Thr Ser Phe Pro  Gly Ser Gly 
    1085                 1090                 1095             


Pro Ser  Leu Ser Ala Glu Glu  Ser Pro Gly Asp Gly  Asp Asn Leu 
    1100                 1105                 1110             


Val Asp  Pro Ser Leu Ser Ala  Gly Arg Ala Glu Pro  Val Leu Met 
    1115                 1120                 1125             


Ile Asp  Trp Pro Lys Ala Leu  Leu Gly Arg Ala Val  Phe Gln Gly 
    1130                 1135                 1140             


Tyr Ser  Ser Ser Gly Ile Thr  Glu Gln Thr Val Thr  Ile Lys Pro 
    1145                 1150                 1155             


Tyr Ser  Leu Ser Ser Gly Glu  Thr Tyr Val Leu Gln  Val Ser Val 
    1160                 1165                 1170             


Ala Ser  Lys His Gly Leu Leu  Gly Lys Ala Gln Leu  Tyr Leu Thr 
    1175                 1180                 1185             


Val Asn  Pro Ala Pro Arg Asp  Met Ala Cys Gln Val  Gln Pro His 
    1190                 1195                 1200             


His Gly  Leu Glu Ala His Thr  Val Phe Ser Val Phe  Cys Met Ser 
    1205                 1210                 1215             


Gly Lys  Pro Asp Phe His Tyr  Glu Phe Ser Tyr Gln  Ile Gly Asn 
    1220                 1225                 1230             


Thr Ser  Lys His Thr Leu Tyr  His Gly Arg Asp Thr  Gln Tyr Tyr 
    1235                 1240                 1245             


Phe Val  Leu Pro Ala Gly Glu  His Leu Asp Asn Tyr  Lys Val Met 
    1250                 1255                 1260             


Val Ser  Thr Glu Ile Thr Asp  Gly Lys Gly Ser Lys  Val Gln Pro 
    1265                 1270                 1275             


Cys Thr  Val Val Val Thr Val  Leu Pro Arg Tyr His  Gly Asn Asp 
    1280                 1285                 1290             


Cys Leu  Gly Glu Asp Leu Tyr  Asn Ser Ser Leu Lys  Asn Leu Ser 
    1295                 1300                 1305             


Thr Leu  Gln Leu Met Gly Ser  Tyr Thr Glu Ile Arg  Asn Tyr Ile 
    1310                 1315                 1320             


Thr Val  Ile Thr Arg Ile Leu  Ser Arg Leu Ser Lys  Glu Asp Lys 
    1325                 1330                 1335             


Thr Ala  Ser Cys Asn Gln Trp  Ser Arg Ile Gln Asp  Ala Leu Ile 
    1340                 1345                 1350             


Ser Ser  Val Cys Arg Leu Ala  Phe Val Asp Gln Glu  Glu Met Ile 
    1355                 1360                 1365             


Gly Ser  Val Leu Met Leu Arg  Asp Leu Val Ser Phe  Ser Asn Lys 
    1370                 1375                 1380             


Leu Gly  Phe Met Ser Ala Val  Leu Ile Leu Lys Tyr  Thr Arg Ala 
    1385                 1390                 1395             


Leu Leu  Ala Gln Gly Gln Phe  Ser Gly Pro Phe Val  Ile Asp Lys 
    1400                 1405                 1410             


Gly Val  Arg Leu Glu Leu Ile  Gly Leu Ile Ser Arg  Val Trp Glu 
    1415                 1420                 1425             


Val Ser  Glu Gln Glu Asn Ser  Lys Glu Glu Val Tyr  Arg His Glu 
    1430                 1435                 1440             


Glu Gly  Ile Thr Val Ile Ser  Asp Leu Leu Leu Gly  Cys Leu Ser 
    1445                 1450                 1455             


Leu Asn  His Val Ser Thr Gly  Gln Met Glu Phe Arg  Thr Leu Leu 
    1460                 1465                 1470             


His Tyr  Asn Leu Gln Ser Ser  Val Gln Ser Leu Gly  Ser Val Gln 
    1475                 1480                 1485             


Val His  Leu Pro Gly Asp Leu  Ala Gly His Ser Pro  Ala Gly Ala 
    1490                 1495                 1500             


Glu Thr  Gln Ser Pro Cys Tyr  Ile Ser Gln Leu Ile  Leu Phe Lys 
    1505                 1510                 1515             


Lys Asn  Pro Tyr Pro Gly Ser  Gln Ala Pro Gly Gln  Ile Gly Gly 
    1520                 1525                 1530             


Val Val  Gly Leu Asn Leu Tyr  Thr Cys Ser Ser Arg  Arg Pro Ile 
    1535                 1540                 1545             


Asn Arg  Gln Trp Leu Arg Lys  Pro Val Met Val Glu  Phe Gly Glu 
    1550                 1555                 1560             


Glu Asp  Gly Leu Asp Asn Arg  Arg Asn Lys Thr Thr  Phe Val Leu 
    1565                 1570                 1575             


Leu Arg  Asp Lys Val Asn Leu  His Gln Phe Thr Glu  Leu Ser Glu 
    1580                 1585                 1590             


Asn Pro  Gln Glu Ser Leu Gln  Ile Glu Ile Glu Phe  Ser Lys Pro 
    1595                 1600                 1605             


Val Thr  Arg Ala Phe Pro Val  Met Leu Leu Val Arg  Phe Ser Glu 
    1610                 1615                 1620             


Lys Pro  Thr Pro Ser Asp Phe  Leu Val Lys Gln Ile  Tyr Phe Trp 
    1625                 1630                 1635             


Asp Glu  Ser Ile Val Gln Ile  Tyr Ile Pro Ala Ala  Ser Gln Lys 
    1640                 1645                 1650             


Asp Ala  Ser Val Gly Tyr Leu  Ser Leu Leu Asp Ala  Asp Tyr Asp 
    1655                 1660                 1665             


Arg Lys  Pro Pro Asn Arg Tyr  Leu Ala Lys Ala Val  Asn Tyr Thr 
    1670                 1675                 1680             


Val His  Phe Gln Trp Ile Arg  Cys Leu Phe Trp Asp  Lys Arg Glu 
    1685                 1690                 1695             


Trp Lys  Ser Glu Arg Phe Ser  Pro Gln Pro Gly Thr  Ser Pro Glu 
    1700                 1705                 1710             


Lys Val  Asn Cys Ser Tyr His  Arg Leu Ala Ala Phe  Ala Leu Leu 
    1715                 1720                 1725             


Arg Arg  Lys Leu Lys Ala Ser  Phe Glu Val Ser Asp  Ile Ser Lys 
    1730                 1735                 1740             


Leu Gln  Ser His Pro Glu Asn  Leu Leu Pro Ser Ile  Phe Ile Met 
    1745                 1750                 1755             


Gly Ser  Val Ile Leu Tyr Gly  Phe Leu Val Ala Lys  Ser Arg Gln 
    1760                 1765                 1770             


Val Asp  His His Glu Lys Lys  Lys Ala Gly Tyr Ile  Phe Leu Gln 
    1775                 1780                 1785             


Glu Ala  Ser Leu Pro Gly His  Gln Leu Tyr Ala Val  Val Ile Asp 
    1790                 1795                 1800             


Thr Gly  Phe Arg Ala Pro Ala  Arg Leu Thr Ser Lys  Val Tyr Ile 
    1805                 1810                 1815             


Val Leu  Cys Gly Asp Asn Gly  Leu Ser Glu Thr Lys  Glu Leu Ser 
    1820                 1825                 1830             


Cys Pro  Glu Lys Pro Leu Phe  Glu Arg Asn Ser Arg  His Thr Phe 
    1835                 1840                 1845             


Ile Leu  Ser Ala Pro Ala Gln  Leu Gly Leu Leu Arg  Lys Ile Arg 
    1850                 1855                 1860             


Leu Trp  His Asp Ser Arg Gly  Pro Ser Pro Gly Trp  Phe Ile Ser 
    1865                 1870                 1875             


His Val  Met Val Lys Glu Leu  His Thr Gly Gln Gly  Trp Phe Phe 
    1880                 1885                 1890             


Pro Ala  Gln Cys Trp Leu Ser  Ala Gly Arg His Asp  Gly Arg Val 
    1895                 1900                 1905             


Glu Arg  Glu Leu Thr Cys Leu  Gln Gly Gly Leu Gly  Phe Arg Lys 
    1910                 1915                 1920             


Leu Phe  Tyr Cys Lys Phe Thr  Glu Tyr Leu Glu Asp  Phe His Val 
    1925                 1930                 1935             


Trp Leu  Ser Val Tyr Ser Arg  Pro Ser Ser Ser Arg  Tyr Leu His 
    1940                 1945                 1950             


Thr Pro  Arg Leu Thr Val Ser  Phe Ser Leu Leu Cys  Val Tyr Ala 
    1955                 1960                 1965             


Cys Leu  Thr Ala Leu Val Ala  Ala Gly Gly Gln Glu  Gln Pro His 
    1970                 1975                 1980             


Leu Asp  Val Ser Pro Thr Leu  Gly Ser Phe Arg Val  Gly Leu Leu 
    1985                 1990                 1995             


Cys Thr  Leu Leu Ala Ser Pro  Gly Ala Gln Leu Leu  Ser Leu Leu 
    2000                 2005                 2010             


Phe Arg  Leu Ser Lys Glu Ala  Pro Gly Ser Ala Arg  Val Glu Pro 
    2015                 2020                 2025             


His Ser  Pro Leu Arg Gly Gly  Ala Gln Thr Glu Ala  Pro His Gly 
    2030                 2035                 2040             


Pro Asn  Ser Trp Gly Arg Ile  Pro Asp Ala Gln Glu  Pro Arg Lys 
    2045                 2050                 2055             


Gln Pro  Ala Ser Ala Ile Leu  Ser Gly Ser Gly Arg  Ala Gln Arg 
    2060                 2065                 2070             


Lys Ala  Ala Ser Asp Asn Gly  Thr Ala Cys Pro Ala  Pro Lys Leu 
    2075                 2080                 2085             


Gln Val  His Gly Ala Asp His  Ser Arg Thr Ser Leu  Met Gly Lys 
    2090                 2095                 2100             


Ser His  Cys Cys Pro Pro His  Thr Gln Ala Pro Ser  Ser Gly Leu 
    2105                 2110                 2115             


Glu Gly  Leu Met Pro Gln Trp  Ser Arg Ala Leu Gln  Pro Trp Trp 
    2120                 2125                 2130             


Ser Ser  Ala Val Trp Ala Ile  Cys Gly Thr Ala Ser  Leu Ala Cys 
    2135                 2140                 2145             


Ser Leu  Gly Thr Gly Phe Leu  Ala Tyr Arg Phe Gly  Gln Glu Gln 
    2150                 2155                 2160             


Cys Val  Gln Trp Leu His Leu  Leu Ser Leu Ser Val  Val Cys Cys 
    2165                 2170                 2175             


Ile Phe  Ile Thr Gln Pro Leu  Met Val Cys Leu Met  Ala Leu Gly 
    2180                 2185                 2190             


Phe Ala  Trp Lys Arg Arg Ala  Asp Asn His Phe Phe  Thr Glu Ser 
    2195                 2200                 2205             


Leu Cys  Glu Ala Thr Arg Asp  Leu Asp Ser Glu Leu  Ala Glu Arg 
    2210                 2215                 2220             


Ser Trp  Thr Arg Leu Pro Phe  Ser Ser Ser Cys Ser  Ile Pro Asp 
    2225                 2230                 2235             


Cys Ala  Gly Glu Val Glu Lys  Val Leu Ala Ala Arg  Gln Gln Ala 
    2240                 2245                 2250             


Arg His  Leu Arg Trp Ala His  Pro Pro Ser Lys Ala  Gln Leu Arg 
    2255                 2260                 2265             


Gly Thr  Arg Gln Arg Met Arg  Arg Glu Ser Arg Thr  Arg Ala Ala 
    2270                 2275                 2280             


Leu Arg  Asp Ile Ser Met Asp  Ile Leu Met Leu Leu  Leu Leu Leu 
    2285                 2290                 2295             


Cys Val  Ile Tyr Gly Arg Phe  Ser Gln Asp Glu Tyr  Ser Leu Asn 
    2300                 2305                 2310             


Gln Ala  Ile Arg Lys Glu Phe  Thr Arg Asn Ala Arg  Asn Cys Leu 
    2315                 2320                 2325             


Gly Gly  Leu Arg Asn Ile Ala  Asp Trp Trp Asp Trp  Ser Leu Thr 
    2330                 2335                 2340             


Thr Leu  Leu Asp Gly Leu Tyr  Pro Gly Gly Thr Pro  Ser Ala Arg 
    2345                 2350                 2355             


Val Pro  Gly Ala Gln Pro Gly  Ala Leu Gly Gly Lys  Cys Tyr Leu 
    2360                 2365                 2370             


Ile Gly  Ser Ser Val Ile Arg  Gln Leu Lys Val Phe  Pro Arg His 
    2375                 2380                 2385             


Leu Cys  Lys Pro Pro Arg Pro  Phe Ser Ala Leu Ile  Glu Asp Ser 
    2390                 2395                 2400             


Ile Pro  Thr Cys Ser Pro Glu  Val Gly Gly Pro Glu  Asn Pro Tyr 
    2405                 2410                 2415             


Leu Ile  Asp Pro Glu Asn Gln  Asn Val Thr Leu Asn  Gly Pro Gly 
    2420                 2425                 2430             


Gly Cys  Gly Thr Arg Glu Asp  Cys Val Leu Ser Leu  Gly Arg Thr 
    2435                 2440                 2445             


Arg Thr  Glu Ala His Thr Ala  Leu Ser Arg Leu Arg  Ala Ser Met 
    2450                 2455                 2460             


Trp Ile  Asp Arg Ser Thr Arg  Ala Val Ser Val His  Phe Thr Leu 
    2465                 2470                 2475             


Tyr Asn  Pro Pro Thr Gln Leu  Phe Thr Ser Val Ser  Leu Arg Val 
    2480                 2485                 2490             


Glu Ile  Leu Pro Thr Gly Ser  Leu Val Pro Ser Ser  Leu Val Glu 
    2495                 2500                 2505             


Ser Phe  Ser Ile Phe Arg Ser  Asp Ser Ala Leu Gln  Tyr His Leu 
    2510                 2515                 2520             


Met Leu  Pro Gln Leu Val Phe  Leu Ala Leu Ser Leu  Ile His Leu 
    2525                 2530                 2535             


Cys Val  Gln Leu Tyr Arg Met  Met Asp Lys Gly Val  Leu Ser Tyr 
    2540                 2545                 2550             


Trp Arg  Lys Pro Arg Asn Trp  Leu Glu Leu Ser Val  Val Gly Val 
    2555                 2560                 2565             


Ser Leu  Thr Tyr Tyr Ala Val  Ser Gly His Leu Val  Thr Leu Ala 
    2570                 2575                 2580             


Gly Asp  Val Thr Asn Gln Phe  His Arg Gly Leu Cys  Arg Ala Phe 
    2585                 2590                 2595             


Met Asp  Leu Thr Leu Met Ala  Ser Trp Asn Gln Arg  Ala Arg Trp 
    2600                 2605                 2610             


Leu Arg  Gly Ile Leu Leu Phe  Leu Phe Thr Leu Lys  Cys Val Tyr 
    2615                 2620                 2625             


Leu Pro  Gly Ile Gln Asn Thr  Met Ala Ser Cys Ser  Ser Met Met 
    2630                 2635                 2640             


Arg His  Ser Leu Pro Ser Ile  Phe Val Ala Gly Leu  Val Gly Ala 
    2645                 2650                 2655             


Leu Met  Leu Ala Ala Leu Ser  His Leu His Arg Phe  Leu Leu Ser 
    2660                 2665                 2670             


Met Trp  Val Leu Pro Pro Gly  Thr Phe Thr Asp Ala  Phe Pro Gly 
    2675                 2680                 2685             


Leu Leu  Phe His Phe Pro Arg  Arg Ser Gln Lys Asp  Cys Leu Leu 
    2690                 2695                 2700             


Gly Leu  Ser Lys Ser Asp Gln  Arg Ala Met Ala Cys  Tyr Phe Gly 
    2705                 2710                 2715             


Ile Leu  Leu Ile Val Ser Ala  Thr Leu Cys Phe Gly  Met Leu Arg 
    2720                 2725                 2730             


Gly Phe  Leu Met Thr Leu Pro  Gln Lys Arg Lys Ser  Phe Gln Ser 
    2735                 2740                 2745             


Lys Ser  Phe Val Arg Leu Lys  Asp Val Thr Ala Tyr  Met Trp Glu 
    2750                 2755                 2760             


Lys Val  Leu Thr Phe Leu Arg  Leu Glu Thr Pro Lys  Leu Glu Glu 
    2765                 2770                 2775             


Ala Glu  Met Val Glu Asn His  Asn Tyr Tyr Leu Asp  Glu Phe Ala 
    2780                 2785                 2790             


Asn Leu  Leu Asp Glu Leu Leu  Met Lys Ile Asn Gly  Leu Ser Asp 
    2795                 2800                 2805             


Ser Leu  Gln Leu Pro Leu Leu  Glu Lys Thr Ser Asn  Asn Thr Gly 
    2810                 2815                 2820             


Glu Ala  Arg Thr Glu Glu Ser  Pro Leu Val Asp Ile  Ser Ser Tyr 
    2825                 2830                 2835             


Gln Ala  Ala Glu Pro Ala Asp  Ile Lys Asp Phe 
    2840                 2845                 


<210>  9
<211>  646
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Cognate thermal shock protein 71 kDa

<220>
<221>  misc_feature
<223>  or heat shock protein cognate 71 kDa (HSPA8)

<400>  9

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His 
225                 230                 235                 240 


Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg 
                405                 410                 415     


Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Val Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Asp Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Lys Gln Arg Asp Lys Val Ser Ser Lys Asn Ser Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ala Thr Val Glu Asp Glu Lys Leu Gln Gly 
545                 550                 555                 560 


Lys Ile Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Glu 
                565                 570                 575     


Ile Ile Asn Trp Leu Asp Lys Asn Gln Thr Ala Glu Lys Glu Glu Phe 
            580                 585                 590         


Glu His Gln Gln Lys Glu Leu Glu Lys Val Cys Asn Pro Ile Ile Thr 
        595                 600                 605             


Lys Leu Tyr Gln Ser Ala Gly Gly Met Pro Gly Gly Met Pro Gly Gly 
    610                 615                 620                 


Phe Pro Gly Gly Gly Ala Pro Pro Ser Gly Gly Ala Ser Ser Gly Pro 
625                 630                 635                 640 


Thr Ile Glu Glu Val Asp 
                645     


<210>  10
<211>  4377
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Anikirina-3

<220>
<221>  misc_feature
<223>  or Ankyrin-3 (ANK3)

<400>  10

Met Ala His Ala Ala Ser Gln Leu Lys Lys Asn Arg Asp Leu Glu Ile 
1               5                   10                  15      


Asn Ala Glu Glu Glu Pro Glu Lys Lys Arg Lys His Arg Lys Arg Ser 
            20                  25                  30          


Arg Asp Arg Lys Lys Lys Ser Asp Ala Asn Ala Ser Tyr Leu Arg Ala 
        35                  40                  45              


Ala Arg Ala Gly His Leu Glu Lys Ala Leu Asp Tyr Ile Lys Asn Gly 
    50                  55                  60                  


Val Asp Ile Asn Ile Cys Asn Gln Asn Gly Leu Asn Ala Leu His Leu 
65                  70                  75                  80  


Ala Ser Lys Glu Gly His Val Glu Val Val Ser Glu Leu Leu Gln Arg 
                85                  90                  95      


Glu Ala Asn Val Asp Ala Ala Thr Lys Lys Gly Asn Thr Ala Leu His 
            100                 105                 110         


Ile Ala Ser Leu Ala Gly Gln Ala Glu Val Val Lys Val Leu Val Thr 
        115                 120                 125             


Asn Gly Ala Asn Val Asn Ala Gln Ser Gln Asn Gly Phe Thr Pro Leu 
    130                 135                 140                 


Tyr Met Ala Ala Gln Glu Asn His Leu Glu Val Val Lys Phe Leu Leu 
145                 150                 155                 160 


Asp Asn Gly Ala Ser Gln Ser Leu Ala Thr Glu Asp Gly Phe Thr Pro 
                165                 170                 175     


Leu Ala Val Ala Leu Gln Gln Gly His Asp Gln Val Val Ser Leu Leu 
            180                 185                 190         


Leu Glu Asn Asp Thr Lys Gly Lys Val Arg Leu Pro Ala Leu His Ile 
        195                 200                 205             


Ala Ala Arg Lys Asp Asp Thr Lys Ala Ala Ala Leu Leu Leu Gln Asn 
    210                 215                 220                 


Asp Asn Asn Ala Asp Val Glu Ser Lys Ser Gly Phe Thr Pro Leu His 
225                 230                 235                 240 


Ile Ala Ala His Tyr Gly Asn Ile Asn Val Ala Thr Leu Leu Leu Asn 
                245                 250                 255     


Arg Ala Ala Ala Val Asp Phe Thr Ala Arg Asn Asp Ile Thr Pro Leu 
            260                 265                 270         


His Val Ala Ser Lys Arg Gly Asn Ala Asn Met Val Lys Leu Leu Leu 
        275                 280                 285             


Asp Arg Gly Ala Lys Ile Asp Ala Lys Thr Arg Asp Gly Leu Thr Pro 
    290                 295                 300                 


Leu His Cys Gly Ala Arg Ser Gly His Glu Gln Val Val Glu Met Leu 
305                 310                 315                 320 


Leu Asp Arg Ala Ala Pro Ile Leu Ser Lys Thr Lys Asn Gly Leu Ser 
                325                 330                 335     


Pro Leu His Met Ala Thr Gln Gly Asp His Leu Asn Cys Val Gln Leu 
            340                 345                 350         


Leu Leu Gln His Asn Val Pro Val Asp Asp Val Thr Asn Asp Tyr Leu 
        355                 360                 365             


Thr Ala Leu His Val Ala Ala His Cys Gly His Tyr Lys Val Ala Lys 
    370                 375                 380                 


Val Leu Leu Asp Lys Lys Ala Asn Pro Asn Ala Lys Ala Leu Asn Gly 
385                 390                 395                 400 


Phe Thr Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met 
                405                 410                 415     


Glu Leu Leu Leu Lys His Gly Ala Ser Ile Gln Ala Val Thr Glu Ser 
            420                 425                 430         


Gly Leu Thr Pro Ile His Val Ala Ala Phe Met Gly His Val Asn Ile 
        435                 440                 445             


Val Ser Gln Leu Met His His Gly Ala Ser Pro Asn Thr Thr Asn Val 
    450                 455                 460                 


Arg Gly Glu Thr Ala Leu His Met Ala Ala Arg Ser Gly Gln Ala Glu 
465                 470                 475                 480 


Val Val Arg Tyr Leu Val Gln Asp Gly Ala Gln Val Glu Ala Lys Ala 
                485                 490                 495     


Lys Asp Asp Gln Thr Pro Leu His Ile Ser Ala Arg Leu Gly Lys Ala 
            500                 505                 510         


Asp Ile Val Gln Gln Leu Leu Gln Gln Gly Ala Ser Pro Asn Ala Ala 
        515                 520                 525             


Thr Thr Ser Gly Tyr Thr Pro Leu His Leu Ser Ala Arg Glu Gly His 
    530                 535                 540                 


Glu Asp Val Ala Ala Phe Leu Leu Asp His Gly Ala Ser Leu Ser Ile 
545                 550                 555                 560 


Thr Thr Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala Lys Tyr Gly 
                565                 570                 575     


Lys Leu Glu Val Ala Asn Leu Leu Leu Gln Lys Ser Ala Ser Pro Asp 
            580                 585                 590         


Ala Ala Gly Lys Ser Gly Leu Thr Pro Leu His Val Ala Ala His Tyr 
        595                 600                 605             


Asp Asn Gln Lys Val Ala Leu Leu Leu Leu Asp Gln Gly Ala Ser Pro 
    610                 615                 620                 


His Ala Ala Ala Lys Asn Gly Tyr Thr Pro Leu His Ile Ala Ala Lys 
625                 630                 635                 640 


Lys Asn Gln Met Asp Ile Ala Thr Thr Leu Leu Glu Tyr Gly Ala Asp 
                645                 650                 655     


Ala Asn Ala Val Thr Arg Gln Gly Ile Ala Ser Val His Leu Ala Ala 
            660                 665                 670         


Gln Glu Gly His Val Asp Met Val Ser Leu Leu Leu Gly Arg Asn Ala 
        675                 680                 685             


Asn Val Asn Leu Ser Asn Lys Ser Gly Leu Thr Pro Leu His Leu Ala 
    690                 695                 700                 


Ala Gln Glu Asp Arg Val Asn Val Ala Glu Val Leu Val Asn Gln Gly 
705                 710                 715                 720 


Ala His Val Asp Ala Gln Thr Lys Met Gly Tyr Thr Pro Leu His Val 
                725                 730                 735     


Gly Cys His Tyr Gly Asn Ile Lys Ile Val Asn Phe Leu Leu Gln His 
            740                 745                 750         


Ser Ala Lys Val Asn Ala Lys Thr Lys Asn Gly Tyr Thr Pro Leu His 
        755                 760                 765             


Gln Ala Ala Gln Gln Gly His Thr His Ile Ile Asn Val Leu Leu Gln 
    770                 775                 780                 


Asn Asn Ala Ser Pro Asn Glu Leu Thr Val Asn Gly Asn Thr Ala Leu 
785                 790                 795                 800 


Gly Ile Ala Arg Arg Leu Gly Tyr Ile Ser Val Val Asp Thr Leu Lys 
                805                 810                 815     


Ile Val Thr Glu Glu Thr Met Thr Thr Thr Thr Val Thr Glu Lys His 
            820                 825                 830         


Lys Met Asn Val Pro Glu Thr Met Asn Glu Val Leu Asp Met Ser Asp 
        835                 840                 845             


Asp Glu Val Arg Lys Ala Asn Ala Pro Glu Met Leu Ser Asp Gly Glu 
    850                 855                 860                 


Tyr Ile Ser Asp Val Glu Glu Gly Glu Asp Ala Met Thr Gly Asp Thr 
865                 870                 875                 880 


Asp Lys Tyr Leu Gly Pro Gln Asp Leu Lys Glu Leu Gly Asp Asp Ser 
                885                 890                 895     


Leu Pro Ala Glu Gly Tyr Met Gly Phe Ser Leu Gly Ala Arg Ser Ala 
            900                 905                 910         


Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser Tyr Thr Leu Asn Arg Ser 
        915                 920                 925             


Ser Tyr Ala Arg Asp Ser Met Met Ile Glu Glu Leu Leu Val Pro Ser 
    930                 935                 940                 


Lys Glu Gln His Leu Thr Phe Thr Arg Glu Phe Asp Ser Asp Ser Leu 
945                 950                 955                 960 


Arg His Tyr Ser Trp Ala Ala Asp Thr Leu Asp Asn Val Asn Leu Val 
                965                 970                 975     


Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala 
            980                 985                 990         


Arg Gly Gly Ser Met Arg Gly Ser  Arg His His Gly Met  Arg Ile Ile 
        995                 1000                 1005             


Ile Pro  Pro Arg Lys Cys Thr  Ala Pro Thr Arg Ile  Thr Cys Arg 
    1010                 1015                 1020             


Leu Val  Lys Arg His Lys Leu  Ala Asn Pro Pro Pro  Met Val Glu 
    1025                 1030                 1035             


Gly Glu  Gly Leu Ala Ser Arg  Leu Val Glu Met Gly  Pro Ala Gly 
    1040                 1045                 1050             


Ala Gln  Phe Leu Gly Pro Val  Ile Val Glu Ile Pro  His Phe Gly 
    1055                 1060                 1065             


Ser Met  Arg Gly Lys Glu Arg  Glu Leu Ile Val Leu  Arg Ser Glu 
    1070                 1075                 1080             


Asn Gly  Glu Thr Trp Lys Glu  His Gln Phe Asp Ser  Lys Asn Glu 
    1085                 1090                 1095             


Asp Leu  Thr Glu Leu Leu Asn  Gly Met Asp Glu Glu  Leu Asp Ser 
    1100                 1105                 1110             


Pro Glu  Glu Leu Gly Lys Lys  Arg Ile Cys Arg Ile  Ile Thr Lys 
    1115                 1120                 1125             


Asp Phe  Pro Gln Tyr Phe Ala  Val Val Ser Arg Ile  Lys Gln Glu 
    1130                 1135                 1140             


Ser Asn  Gln Ile Gly Pro Glu  Gly Gly Ile Leu Ser  Ser Thr Thr 
    1145                 1150                 1155             


Val Pro  Leu Val Gln Ala Ser  Phe Pro Glu Gly Ala  Leu Thr Lys 
    1160                 1165                 1170             


Arg Ile  Arg Val Gly Leu Gln  Ala Gln Pro Val Pro  Asp Glu Ile 
    1175                 1180                 1185             


Val Lys  Lys Ile Leu Gly Asn  Lys Ala Thr Phe Ser  Pro Ile Val 
    1190                 1195                 1200             


Thr Val  Glu Pro Arg Arg Arg  Lys Phe His Lys Pro  Ile Thr Met 
    1205                 1210                 1215             


Thr Ile  Pro Val Pro Pro Pro  Ser Gly Glu Gly Val  Ser Asn Gly 
    1220                 1225                 1230             


Tyr Lys  Gly Asp Thr Thr Pro  Asn Leu Arg Leu Leu  Cys Ser Ile 
    1235                 1240                 1245             


Thr Gly  Gly Thr Ser Pro Ala  Gln Trp Glu Asp Ile  Thr Gly Thr 
    1250                 1255                 1260             


Thr Pro  Leu Thr Phe Ile Lys  Asp Cys Val Ser Phe  Thr Thr Asn 
    1265                 1270                 1275             


Val Ser  Ala Arg Phe Trp Leu  Ala Asp Cys His Gln  Val Leu Glu 
    1280                 1285                 1290             


Thr Val  Gly Leu Ala Thr Gln  Leu Tyr Arg Glu Leu  Ile Cys Val 
    1295                 1300                 1305             


Pro Tyr  Met Ala Lys Phe Val  Val Phe Ala Lys Met  Asn Asp Pro 
    1310                 1315                 1320             


Val Glu  Ser Ser Leu Arg Cys  Phe Cys Met Thr Asp  Asp Lys Val 
    1325                 1330                 1335             


Asp Lys  Thr Leu Glu Gln Gln  Glu Asn Phe Glu Glu  Val Ala Arg 
    1340                 1345                 1350             


Ser Lys  Asp Ile Glu Val Leu  Glu Gly Lys Pro Ile  Tyr Val Asp 
    1355                 1360                 1365             


Cys Tyr  Gly Asn Leu Ala Pro  Leu Thr Lys Gly Gly  Gln Gln Leu 
    1370                 1375                 1380             


Val Phe  Asn Phe Tyr Ser Phe  Lys Glu Asn Arg Leu  Pro Phe Ser 
    1385                 1390                 1395             


Ile Lys  Ile Arg Asp Thr Ser  Gln Glu Pro Cys Gly  Arg Leu Ser 
    1400                 1405                 1410             


Phe Leu  Lys Glu Pro Lys Thr  Thr Lys Gly Leu Pro  Gln Thr Ala 
    1415                 1420                 1425             


Val Cys  Asn Leu Asn Ile Thr  Leu Pro Ala His Lys  Lys Glu Thr 
    1430                 1435                 1440             


Glu Ser  Asp Gln Asp Asp Glu  Ile Glu Lys Thr Asp  Arg Arg Gln 
    1445                 1450                 1455             


Ser Phe  Ala Ser Leu Ala Leu  Arg Lys Arg Tyr Ser  Tyr Leu Thr 
    1460                 1465                 1470             


Glu Pro  Gly Met Ile Glu Arg  Ser Thr Gly Ala Thr  Arg Ser Leu 
    1475                 1480                 1485             


Pro Thr  Thr Tyr Ser Tyr Lys  Pro Phe Phe Ser Thr  Arg Pro Tyr 
    1490                 1495                 1500             


Gln Ser  Trp Thr Thr Ala Pro  Ile Thr Val Pro Gly  Pro Ala Lys 
    1505                 1510                 1515             


Ser Gly  Phe Thr Ser Leu Ser  Ser Ser Ser Ser Asn  Thr Pro Ser 
    1520                 1525                 1530             


Ala Ser  Pro Leu Lys Ser Ile  Trp Ser Val Ser Thr  Pro Ser Pro 
    1535                 1540                 1545             


Ile Lys  Ser Thr Leu Gly Ala  Ser Thr Thr Ser Ser  Val Lys Ser 
    1550                 1555                 1560             


Ile Ser  Asp Val Ala Ser Pro  Ile Arg Ser Phe Arg  Thr Met Ser 
    1565                 1570                 1575             


Ser Pro  Ile Lys Thr Val Val  Ser Gln Ser Pro Tyr  Asn Ile Gln 
    1580                 1585                 1590             


Val Ser  Ser Gly Thr Leu Ala  Arg Ala Pro Ala Val  Thr Glu Ala 
    1595                 1600                 1605             


Thr Pro  Leu Lys Gly Leu Ala  Ser Asn Ser Thr Phe  Ser Ser Arg 
    1610                 1615                 1620             


Thr Ser  Pro Val Thr Thr Ala  Gly Ser Leu Leu Glu  Arg Ser Ser 
    1625                 1630                 1635             


Ile Thr  Met Thr Pro Pro Ala  Ser Pro Lys Ser Asn  Ile Asn Met 
    1640                 1645                 1650             


Tyr Ser  Ser Ser Leu Pro Phe  Lys Ser Ile Ile Thr  Ser Ala Ala 
    1655                 1660                 1665             


Pro Leu  Ile Ser Ser Pro Leu  Lys Ser Val Val Ser  Pro Val Lys 
    1670                 1675                 1680             


Ser Ala  Val Asp Val Ile Ser  Ser Ala Lys Ile Thr  Met Ala Ser 
    1685                 1690                 1695             


Ser Leu  Ser Ser Pro Val Lys  Gln Met Pro Gly His  Ala Glu Val 
    1700                 1705                 1710             


Ala Leu  Val Asn Gly Ser Ile  Ser Pro Leu Lys Tyr  Pro Ser Ser 
    1715                 1720                 1725             


Ser Thr  Leu Ile Asn Gly Cys  Lys Ala Thr Ala Thr  Leu Gln Glu 
    1730                 1735                 1740             


Lys Ile  Ser Ser Ala Thr Asn  Ser Val Ser Ser Val  Val Ser Ala 
    1745                 1750                 1755             


Ala Thr  Asp Thr Val Glu Lys  Val Phe Ser Thr Thr  Thr Ala Met 
    1760                 1765                 1770             


Pro Phe  Ser Pro Leu Arg Ser  Tyr Val Ser Ala Ala  Pro Ser Ala 
    1775                 1780                 1785             


Phe Gln  Ser Leu Arg Thr Pro  Ser Ala Ser Ala Leu  Tyr Thr Ser 
    1790                 1795                 1800             


Leu Gly  Ser Ser Ile Ser Ala  Thr Thr Ser Ser Val  Thr Ser Ser 
    1805                 1810                 1815             


Ile Ile  Thr Val Pro Val Tyr  Ser Val Val Asn Val  Leu Pro Glu 
    1820                 1825                 1830             


Pro Ala  Leu Lys Lys Leu Pro  Asp Ser Asn Ser Phe  Thr Lys Ser 
    1835                 1840                 1845             


Ala Ala  Ala Leu Leu Ser Pro  Ile Lys Thr Leu Thr  Thr Glu Thr 
    1850                 1855                 1860             


His Pro  Gln Pro His Phe Ser  Arg Thr Ser Ser Pro  Val Lys Ser 
    1865                 1870                 1875             


Ser Leu  Phe Leu Ala Pro Ser  Ala Leu Lys Leu Ser  Thr Pro Ser 
    1880                 1885                 1890             


Ser Leu  Ser Ser Ser Gln Glu  Ile Leu Lys Asp Val  Ala Glu Met 
    1895                 1900                 1905             


Lys Glu  Asp Leu Met Arg Met  Thr Ala Ile Leu Gln  Thr Asp Val 
    1910                 1915                 1920             


Pro Glu  Glu Lys Pro Phe Gln  Pro Glu Leu Pro Lys  Glu Gly Arg 
    1925                 1930                 1935             


Ile Asp  Asp Glu Glu Pro Phe  Lys Ile Val Glu Lys  Val Lys Glu 
    1940                 1945                 1950             


Asp Leu  Val Lys Val Ser Glu  Ile Leu Lys Lys Asp  Val Cys Val 
    1955                 1960                 1965             


Asp Asn  Lys Gly Ser Pro Lys  Ser Pro Lys Ser Asp  Lys Gly His 
    1970                 1975                 1980             


Ser Pro  Glu Asp Asp Trp Ile  Glu Phe Ser Ser Glu  Glu Ile Arg 
    1985                 1990                 1995             


Glu Ala  Arg Gln Gln Ala Ala  Ala Ser Gln Ser Pro  Ser Leu Pro 
    2000                 2005                 2010             


Glu Arg  Val Gln Val Lys Ala  Lys Ala Ala Ser Glu  Lys Asp Tyr 
    2015                 2020                 2025             


Asn Leu  Thr Lys Val Ile Asp  Tyr Leu Thr Asn Asp  Ile Gly Ser 
    2030                 2035                 2040             


Ser Ser  Leu Thr Asn Leu Lys  Tyr Lys Phe Glu Asp  Ala Lys Lys 
    2045                 2050                 2055             


Asp Gly  Glu Glu Arg Gln Lys  Arg Val Leu Lys Pro  Ala Ile Ala 
    2060                 2065                 2070             


Leu Gln  Glu His Lys Leu Lys  Met Pro Pro Ala Ser  Met Arg Thr 
    2075                 2080                 2085             


Ser Thr  Ser Glu Lys Glu Leu  Cys Lys Met Ala Asp  Ser Phe Phe 
    2090                 2095                 2100             


Gly Thr  Asp Thr Ile Leu Glu  Ser Pro Asp Asp Phe  Ser Gln His 
    2105                 2110                 2115             


Asp Gln  Asp Lys Ser Pro Leu  Ser Asp Ser Gly Phe  Glu Thr Arg 
    2120                 2125                 2130             


Ser Glu  Lys Thr Pro Ser Ala  Pro Gln Ser Ala Glu  Ser Thr Gly 
    2135                 2140                 2145             


Pro Lys  Pro Leu Phe His Glu  Val Pro Ile Pro Pro  Val Ile Thr 
    2150                 2155                 2160             


Glu Thr  Arg Thr Glu Val Val  His Val Ile Arg Ser  Tyr Asp Pro 
    2165                 2170                 2175             


Ser Ala  Gly Asp Val Pro Gln  Thr Gln Pro Glu Glu  Pro Val Ser 
    2180                 2185                 2190             


Pro Lys  Pro Ser Pro Thr Phe  Met Glu Leu Glu Pro  Lys Pro Thr 
    2195                 2200                 2205             


Thr Ser  Ser Ile Lys Glu Lys  Val Lys Ala Phe Gln  Met Lys Ala 
    2210                 2215                 2220             


Ser Ser  Glu Glu Asp Asp His  Asn Arg Val Leu Ser  Lys Gly Met 
    2225                 2230                 2235             


Arg Val  Lys Glu Glu Thr His  Ile Thr Thr Thr Thr  Arg Met Val 
    2240                 2245                 2250             


Tyr His  Ser Pro Pro Gly Gly  Glu Gly Ala Ser Glu  Arg Ile Glu 
    2255                 2260                 2265             


Glu Thr  Met Ser Val His Asp  Ile Met Lys Ala Phe  Gln Ser Gly 
    2270                 2275                 2280             


Arg Asp  Pro Ser Lys Glu Leu  Ala Gly Leu Phe Glu  His Lys Ser 
    2285                 2290                 2295             


Ala Val  Ser Pro Asp Val His  Lys Ser Ala Ala Glu  Thr Ser Ala 
    2300                 2305                 2310             


Gln His  Ala Glu Lys Asp Asn  Gln Met Lys Pro Lys  Leu Glu Arg 
    2315                 2320                 2325             


Ile Ile  Glu Val His Ile Glu  Lys Gly Asn Gln Ala  Glu Pro Thr 
    2330                 2335                 2340             


Glu Val  Ile Ile Arg Glu Thr  Lys Lys His Pro Glu  Lys Glu Met 
    2345                 2350                 2355             


Tyr Val  Tyr Gln Lys Asp Leu  Ser Arg Gly Asp Ile  Asn Leu Lys 
    2360                 2365                 2370             


Asp Phe  Leu Pro Glu Lys His  Asp Ala Phe Pro Cys  Ser Glu Glu 
    2375                 2380                 2385             


Gln Gly  Gln Gln Glu Glu Glu  Glu Leu Thr Ala Glu  Glu Ser Leu 
    2390                 2395                 2400             


Pro Ser  Tyr Leu Glu Ser Ser  Arg Val Asn Thr Pro  Val Ser Gln 
    2405                 2410                 2415             


Glu Glu  Asp Ser Arg Pro Ser  Ser Ala Gln Leu Ile  Ser Asp Asp 
    2420                 2425                 2430             


Ser Tyr  Lys Thr Leu Lys Leu  Leu Ser Gln His Ser  Ile Glu Tyr 
    2435                 2440                 2445             


His Asp  Asp Glu Leu Ser Glu  Leu Arg Gly Glu Ser  Tyr Arg Phe 
    2450                 2455                 2460             


Ala Glu  Lys Met Leu Leu Ser  Glu Lys Leu Asp Val  Ser His Ser 
    2465                 2470                 2475             


Asp Thr  Glu Glu Ser Val Thr  Asp His Ala Gly Pro  Pro Ser Ser 
    2480                 2485                 2490             


Glu Leu  Gln Gly Ser Asp Lys  Arg Ser Arg Glu Lys  Ile Ala Thr 
    2495                 2500                 2505             


Ala Pro  Lys Lys Glu Ile Leu  Ser Lys Ile Tyr Lys  Asp Val Ser 
    2510                 2515                 2520             


Glu Asn  Gly Val Gly Lys Val  Ser Lys Asp Glu His  Phe Asp Lys 
    2525                 2530                 2535             


Val Thr  Val Leu His Tyr Ser  Gly Asn Val Ser Ser  Pro Lys His 
    2540                 2545                 2550             


Ala Met  Trp Met Arg Phe Thr  Glu Asp Arg Leu Asp  Arg Gly Arg 
    2555                 2560                 2565             


Glu Lys  Leu Ile Tyr Glu Asp  Arg Val Asp Arg Thr  Val Lys Glu 
    2570                 2575                 2580             


Ala Glu  Glu Lys Leu Thr Glu  Val Ser Gln Phe Phe  Arg Asp Lys 
    2585                 2590                 2595             


Thr Glu  Lys Leu Asn Asp Glu  Leu Gln Ser Pro Glu  Lys Lys Ala 
    2600                 2605                 2610             


Arg Pro  Lys Asn Gly Lys Glu  Tyr Ser Ser Gln Ser  Pro Thr Ser 
    2615                 2620                 2625             


Ser Ser  Pro Glu Lys Val Leu  Leu Thr Glu Leu Leu  Ala Ser Asn 
    2630                 2635                 2640             


Asp Glu  Trp Val Lys Ala Arg  Gln His Gly Pro Asp  Gly Gln Gly 
    2645                 2650                 2655             


Phe Pro  Lys Ala Glu Glu Lys  Ala Pro Ser Leu Pro  Ser Ser Pro 
    2660                 2665                 2670             


Glu Lys  Met Val Leu Ser Gln  Gln Thr Glu Asp Ser  Lys Ser Thr 
    2675                 2680                 2685             


Val Glu  Ala Lys Gly Ser Ile  Ser Gln Ser Lys Ala  Pro Asp Gly 
    2690                 2695                 2700             


Pro Gln  Ser Gly Phe Gln Leu  Lys Gln Ser Lys Leu  Ser Ser Ile 
    2705                 2710                 2715             


Arg Leu  Lys Phe Glu Gln Gly  Thr His Ala Lys Ser  Lys Asp Met 
    2720                 2725                 2730             


Ser Gln  Glu Asp Arg Lys Ser  Asp Gly Gln Ser Arg  Ile Pro Val 
    2735                 2740                 2745             


Lys Lys  Ile Gln Glu Ser Lys  Leu Pro Val Tyr Gln  Val Phe Ala 
    2750                 2755                 2760             


Arg Glu  Lys Gln Gln Lys Ala  Ile Asp Leu Pro Asp  Glu Ser Val 
    2765                 2770                 2775             


Ser Val  Gln Lys Asp Phe Met  Val Leu Lys Thr Lys  Asp Glu His 
    2780                 2785                 2790             


Ala Gln  Ser Asn Glu Ile Val  Val Asn Asp Ser Gly  Ser Asp Asn 
    2795                 2800                 2805             


Val Lys  Lys Gln Arg Thr Glu  Met Ser Ser Lys Ala  Met Pro Asp 
    2810                 2815                 2820             


Ser Phe  Ser Glu Gln Gln Ala  Lys Asp Leu Ala Cys  His Ile Thr 
    2825                 2830                 2835             


Ser Asp  Leu Ala Thr Arg Gly  Pro Trp Asp Lys Lys  Val Phe Arg 
    2840                 2845                 2850             


Thr Trp  Glu Ser Ser Gly Ala  Thr Asn Asn Lys Ser  Gln Lys Glu 
    2855                 2860                 2865             


Lys Leu  Ser His Val Leu Val  His Asp Val Arg Glu  Asn His Ile 
    2870                 2875                 2880             


Gly His  Pro Glu Ser Lys Ser  Val Asp Gln Lys Asn  Glu Phe Met 
    2885                 2890                 2895             


Ser Val  Thr Glu Arg Glu Arg  Lys Leu Leu Thr Asn  Gly Ser Leu 
    2900                 2905                 2910             


Ser Glu  Ile Lys Glu Met Thr  Val Lys Ser Pro Ser  Lys Lys Val 
    2915                 2920                 2925             


Leu Tyr  Arg Glu Tyr Val Val  Lys Glu Gly Asp His  Pro Gly Gly 
    2930                 2935                 2940             


Leu Leu  Asp Gln Pro Ser Arg  Arg Ser Glu Ser Ser  Ala Val Ser 
    2945                 2950                 2955             


His Ile  Pro Val Arg Val Ala  Asp Glu Arg Arg Met  Leu Ser Ser 
    2960                 2965                 2970             


Asn Ile  Pro Asp Gly Phe Cys  Glu Gln Ser Ala Phe  Pro Lys His 
    2975                 2980                 2985             


Glu Leu  Ser Gln Lys Leu Ser  Gln Ser Ser Met Ser  Lys Glu Thr 
    2990                 2995                 3000             


Val Glu  Thr Gln His Phe Asn  Ser Ile Glu Asp Glu  Lys Val Thr 
    3005                 3010                 3015             


Tyr Ser  Glu Ile Ser Lys Val  Ser Lys His Gln Ser  Tyr Val Gly 
    3020                 3025                 3030             


Leu Cys  Pro Pro Leu Glu Glu  Thr Glu Thr Ser Pro  Thr Lys Ser 
    3035                 3040                 3045             


Pro Asp  Ser Leu Glu Phe Ser  Pro Gly Lys Glu Ser  Pro Ser Ser 
    3050                 3055                 3060             


Asp Val  Phe Asp His Ser Pro  Ile Asp Gly Leu Glu  Lys Leu Ala 
    3065                 3070                 3075             


Pro Leu  Ala Gln Thr Glu Gly  Gly Lys Glu Ile Lys  Thr Leu Pro 
    3080                 3085                 3090             


Val Tyr  Val Ser Phe Val Gln  Val Gly Lys Gln Tyr  Glu Lys Glu 
    3095                 3100                 3105             


Ile Gln  Gln Gly Gly Val Lys  Lys Ile Ile Ser Gln  Glu Cys Lys 
    3110                 3115                 3120             


Thr Val  Gln Glu Thr Arg Gly  Thr Phe Tyr Thr Thr  Arg Gln Gln 
    3125                 3130                 3135             


Lys Gln  Pro Pro Ser Pro Gln  Gly Ser Pro Glu Asp  Asp Thr Leu 
    3140                 3145                 3150             


Glu Gln  Val Ser Phe Leu Asp  Ser Ser Gly Lys Ser  Pro Leu Thr 
    3155                 3160                 3165             


Pro Glu  Thr Pro Ser Ser Glu  Glu Val Ser Tyr Glu  Phe Thr Ser 
    3170                 3175                 3180             


Lys Thr  Pro Asp Ser Leu Ile  Ala Tyr Ile Pro Gly  Lys Pro Ser 
    3185                 3190                 3195             


Pro Ile  Pro Glu Val Ser Glu  Glu Ser Glu Glu Glu  Glu Gln Ala 
    3200                 3205                 3210             


Lys Ser  Thr Ser Leu Lys Gln  Thr Thr Val Glu Glu  Thr Ala Val 
    3215                 3220                 3225             


Glu Arg  Glu Met Pro Asn Asp  Val Ser Lys Asp Ser  Asn Gln Arg 
    3230                 3235                 3240             


Pro Lys  Asn Asn Arg Val Ala  Tyr Ile Glu Phe Pro  Pro Pro Pro 
    3245                 3250                 3255             


Pro Leu  Asp Ala Asp Gln Ile  Glu Ser Asp Lys Lys  His His Tyr 
    3260                 3265                 3270             


Leu Pro  Glu Lys Glu Val Asp  Met Ile Glu Val Asn  Leu Gln Asp 
    3275                 3280                 3285             


Glu His  Asp Lys Tyr Gln Leu  Ala Glu Pro Val Ile  Arg Val Gln 
    3290                 3295                 3300             


Pro Pro  Ser Pro Val Pro Pro  Gly Ala Asp Val Ser  Asp Ser Ser 
    3305                 3310                 3315             


Asp Asp  Glu Ser Ile Tyr Gln  Pro Val Pro Val Lys  Lys Tyr Thr 
    3320                 3325                 3330             


Phe Lys  Leu Lys Glu Val Asp  Asp Glu Gln Lys Glu  Lys Pro Lys 
    3335                 3340                 3345             


Ala Ser  Ala Glu Lys Ala Ser  Asn Gln Lys Glu Leu  Glu Ser Asn 
    3350                 3355                 3360             


Gly Ser  Gly Lys Asp Asn Glu  Phe Gly Leu Gly Leu  Asp Ser Pro 
    3365                 3370                 3375             


Gln Asn  Glu Ile Ala Gln Asn  Gly Asn Asn Asp Gln  Ser Ile Thr 
    3380                 3385                 3390             


Glu Cys  Ser Ile Ala Thr Thr  Ala Glu Phe Ser His  Asp Thr Asp 
    3395                 3400                 3405             


Ala Thr  Glu Ile Asp Ser Leu  Asp Gly Tyr Asp Leu  Gln Asp Glu 
    3410                 3415                 3420             


Asp Asp  Gly Leu Thr Glu Ser  Asp Ser Lys Leu Pro  Ile Gln Ala 
    3425                 3430                 3435             


Met Glu  Ile Lys Lys Asp Ile  Trp Asn Thr Glu Gly  Ile Leu Lys 
    3440                 3445                 3450             


Pro Ala  Asp Arg Ser Phe Ser  Gln Ser Lys Leu Glu  Val Ile Glu 
    3455                 3460                 3465             


Glu Glu  Gly Lys Val Gly Pro  Asp Glu Asp Lys Pro  Pro Ser Lys 
    3470                 3475                 3480             


Ser Ser  Ser Ser Glu Lys Thr  Pro Asp Lys Thr Asp  Gln Lys Ser 
    3485                 3490                 3495             


Gly Ala  Gln Phe Phe Thr Leu  Glu Gly Arg His Pro  Asp Arg Ser 
    3500                 3505                 3510             


Val Phe  Pro Asp Thr Tyr Phe  Ser Tyr Lys Val Asp  Glu Glu Phe 
    3515                 3520                 3525             


Ala Thr  Pro Phe Lys Thr Val  Ala Thr Lys Gly Leu  Asp Phe Asp 
    3530                 3535                 3540             


Pro Trp  Ser Asn Asn Arg Gly  Asp Asp Glu Val Phe  Asp Ser Lys 
    3545                 3550                 3555             


Ser Arg  Glu Asp Glu Thr Lys  Pro Phe Gly Leu Ala  Val Glu Asp 
    3560                 3565                 3570             


Arg Ser  Pro Ala Thr Thr Pro  Asp Thr Thr Pro Ala  Arg Thr Pro 
    3575                 3580                 3585             


Thr Asp  Glu Ser Thr Pro Thr  Ser Glu Pro Asn Pro  Phe Pro Phe 
    3590                 3595                 3600             


His Glu  Gly Lys Met Phe Glu  Met Thr Arg Ser Gly  Ala Ile Asp 
    3605                 3610                 3615             


Met Ser  Lys Arg Asp Phe Val  Glu Glu Arg Leu Gln  Phe Phe Gln 
    3620                 3625                 3630             


Ile Gly  Glu His Thr Ser Glu  Gly Lys Ser Gly Asp  Gln Gly Glu 
    3635                 3640                 3645             


Gly Asp  Lys Ser Met Val Thr  Ala Thr Pro Gln Pro  Gln Ser Gly 
    3650                 3655                 3660             


Asp Thr  Thr Val Glu Thr Asn  Leu Glu Arg Asn Val  Glu Thr Pro 
    3665                 3670                 3675             


Thr Val  Glu Pro Asn Pro Ser  Ile Pro Thr Ser Gly  Glu Cys Gln 
    3680                 3685                 3690             


Glu Gly  Thr Ser Ser Ser Gly  Ser Leu Glu Lys Ser  Ala Ala Ala 
    3695                 3700                 3705             


Thr Asn  Thr Ser Lys Val Asp  Pro Lys Leu Arg Thr  Pro Ile Lys 
    3710                 3715                 3720             


Met Gly  Ile Ser Ala Ser Thr  Met Thr Met Lys Lys  Glu Gly Pro 
    3725                 3730                 3735             


Gly Glu  Ile Thr Asp Lys Ile  Glu Ala Val Met Thr  Ser Cys Gln 
    3740                 3745                 3750             


Gly Leu  Glu Asn Glu Thr Ile  Thr Met Ile Ser Asn  Thr Ala Asn 
    3755                 3760                 3765             


Ser Gln  Met Gly Val Arg Pro  His Glu Lys His Asp  Phe Gln Lys 
    3770                 3775                 3780             


Asp Asn  Phe Asn Asn Asn Asn  Asn Leu Asp Ser Ser  Thr Ile Gln 
    3785                 3790                 3795             


Thr Asp  Asn Ile Met Ser Asn  Ile Val Leu Thr Glu  His Ser Ala 
    3800                 3805                 3810             


Pro Thr  Cys Thr Thr Glu Lys  Asp Asn Pro Val Lys  Val Ser Ser 
    3815                 3820                 3825             


Gly Lys  Lys Thr Gly Val Leu  Gln Gly His Cys Val  Arg Asp Lys 
    3830                 3835                 3840             


Gln Lys  Val Leu Gly Glu Gln  Gln Lys Thr Lys Glu  Leu Ile Gly 
    3845                 3850                 3855             


Ile Arg  Gln Lys Ser Lys Leu  Pro Ile Lys Ala Thr  Ser Pro Lys 
    3860                 3865                 3870             


Asp Thr  Phe Pro Pro Asn His  Met Ser Asn Thr Lys  Ala Ser Lys 
    3875                 3880                 3885             


Met Lys  Gln Val Ser Gln Ser  Glu Lys Thr Lys Ala  Leu Thr Thr 
    3890                 3895                 3900             


Ser Ser  Cys Val Asp Val Lys  Ser Arg Ile Pro Val  Lys Asn Thr 
    3905                 3910                 3915             


His Arg  Asp Asn Ile Ile Ala  Val Arg Lys Ala Cys  Ala Thr Gln 
    3920                 3925                 3930             


Lys Gln  Gly Gln Pro Glu Lys  Gly Lys Ala Lys Gln  Leu Pro Ser 
    3935                 3940                 3945             


Lys Leu  Pro Val Lys Val Arg  Ser Thr Cys Val Thr  Thr Thr Thr 
    3950                 3955                 3960             


Thr Thr  Ala Thr Thr Thr Thr  Thr Thr Thr Thr Thr  Thr Thr Thr 
    3965                 3970                 3975             


Ser Cys  Thr Val Lys Val Arg  Lys Ser Gln Leu Lys  Glu Val Cys 
    3980                 3985                 3990             


Lys His  Ser Ile Glu Tyr Phe  Lys Gly Ile Ser Gly  Glu Thr Leu 
    3995                 4000                 4005             


Lys Leu  Val Asp Arg Leu Ser  Glu Glu Glu Lys Lys  Met Gln Ser 
    4010                 4015                 4020             


Glu Leu  Ser Asp Glu Glu Glu  Ser Thr Ser Arg Asn  Thr Ser Leu 
    4025                 4030                 4035             


Ser Glu  Thr Ser Arg Gly Gly  Gln Pro Ser Val Thr  Thr Lys Ser 
    4040                 4045                 4050             


Ala Arg  Asp Lys Lys Thr Glu  Ala Ala Pro Leu Lys  Ser Lys Ser 
    4055                 4060                 4065             


Glu Lys  Ala Gly Ser Glu Lys  Arg Ser Ser Arg Arg  Thr Gly Pro 
    4070                 4075                 4080             


Gln Ser  Pro Cys Glu Arg Thr  Asp Ile Arg Met Ala  Ile Val Ala 
    4085                 4090                 4095             


Asp His  Leu Gly Leu Ser Trp  Thr Glu Leu Ala Arg  Glu Leu Asn 
    4100                 4105                 4110             


Phe Ser  Val Asp Glu Ile Asn  Gln Ile Arg Val Glu  Asn Pro Asn 
    4115                 4120                 4125             


Ser Leu  Ile Ser Gln Ser Phe  Met Leu Leu Lys Lys  Trp Val Thr 
    4130                 4135                 4140             


Arg Asp  Gly Lys Asn Ala Thr  Thr Asp Ala Leu Thr  Ser Val Leu 
    4145                 4150                 4155             


Thr Lys  Ile Asn Arg Ile Asp  Ile Val Thr Leu Leu  Glu Gly Pro 
    4160                 4165                 4170             


Ile Phe  Asp Tyr Gly Asn Ile  Ser Gly Thr Arg Ser  Phe Ala Asp 
    4175                 4180                 4185             


Glu Asn  Asn Val Phe His Asp  Pro Val Asp Gly Trp  Gln Asn Glu 
    4190                 4195                 4200             


Thr Ser  Ser Gly Asn Leu Glu  Ser Cys Ala Gln Ala  Arg Arg Val 
    4205                 4210                 4215             


Thr Gly  Gly Leu Leu Asp Arg  Leu Asp Asp Ser Pro  Asp Gln Cys 
    4220                 4225                 4230             


Arg Asp  Ser Ile Thr Ser Tyr  Leu Lys Gly Glu Ala  Gly Lys Phe 
    4235                 4240                 4245             


Glu Ala  Asn Gly Ser His Thr  Glu Ile Thr Pro Glu  Ala Lys Thr 
    4250                 4255                 4260             


Lys Ser  Tyr Phe Pro Glu Ser  Gln Asn Asp Val Gly  Lys Gln Ser 
    4265                 4270                 4275             


Thr Lys  Glu Thr Leu Lys Pro  Lys Ile His Gly Ser  Gly His Val 
    4280                 4285                 4290             


Glu Glu  Pro Ala Ser Pro Leu  Ala Ala Tyr Gln Lys  Ser Leu Glu 
    4295                 4300                 4305             


Glu Thr  Ser Lys Leu Ile Ile  Glu Glu Thr Lys Pro  Cys Val Pro 
    4310                 4315                 4320             


Val Ser  Met Lys Lys Met Ser  Arg Thr Ser Pro Ala  Asp Gly Lys 
    4325                 4330                 4335             


Pro Arg  Leu Ser Leu His Glu  Glu Glu Gly Ser Ser  Gly Ser Glu 
    4340                 4345                 4350             


Gln Lys  Gln Gly Glu Gly Phe  Lys Val Lys Thr Lys  Lys Glu Ile 
    4355                 4360                 4365             


Arg His  Val Glu Lys Lys Ser  His Ser 
    4370                 4375         


<210>  11
<211>  1491
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Rho 23

<220>
<221>  misc_feature
<223>  or Rho GTPase-activating protein 23 (ARHGAP23)

<400>  11

Met Asn Gly Val Ala Phe Cys Leu Val Gly Ile Pro Pro Arg Pro Glu 
1               5                   10                  15      


Pro Arg Pro Pro Gln Leu Pro Leu Gly Pro Arg Asp Gly Cys Ser Pro 
            20                  25                  30          


Arg Arg Pro Phe Pro Trp Gln Gly Pro Arg Thr Leu Leu Leu Tyr Lys 
        35                  40                  45              


Ser Pro Gln Asp Gly Phe Gly Phe Thr Leu Arg His Phe Ile Val Tyr 
    50                  55                  60                  


Pro Pro Glu Ser Ala Val His Cys Ser Leu Lys Glu Glu Glu Asn Gly 
65                  70                  75                  80  


Gly Arg Gly Gly Gly Pro Ser Pro Arg Tyr Arg Leu Glu Pro Met Asp 
                85                  90                  95      


Thr Ile Phe Val Lys Asn Val Lys Glu Asp Gly Pro Ala His Arg Ala 
            100                 105                 110         


Gly Leu Arg Thr Gly Asp Arg Leu Val Lys Val Asn Gly Glu Ser Val 
        115                 120                 125             


Ile Gly Lys Thr Tyr Ser Gln Val Ile Ala Leu Ile Gln Asn Ser Asp 
    130                 135                 140                 


Asp Thr Leu Glu Leu Ser Ile Met Pro Lys Asp Glu Asp Ile Leu Gln 
145                 150                 155                 160 


Leu Ala Tyr Ser Gln Asp Ala Tyr Leu Lys Gly Asn Glu Pro Tyr Ser 
                165                 170                 175     


Gly Glu Ala Arg Ser Ile Pro Glu Pro Pro Pro Ile Cys Tyr Pro Arg 
            180                 185                 190         


Lys Thr Tyr Ala Pro Pro Ala Arg Ala Ser Thr Arg Ala Thr Met Val 
        195                 200                 205             


Pro Glu Pro Thr Ser Ala Leu Pro Ser Asp Pro Arg Ser Pro Ala Ala 
    210                 215                 220                 


Trp Ser Asp Pro Gly Leu Arg Val Pro Pro Ala Ala Arg Ala His Leu 
225                 230                 235                 240 


Asp Asn Ser Ser Leu Gly Met Ser Gln Pro Arg Pro Ser Pro Gly Ala 
                245                 250                 255     


Phe Pro His Leu Ser Ser Glu Pro Arg Thr Pro Arg Ala Phe Pro Glu 
            260                 265                 270         


Pro Gly Ser Arg Val Pro Pro Ser Arg Leu Glu Cys Gln Gln Ala Leu 
        275                 280                 285             


Ser His Trp Leu Ser Asn Gln Val Pro Arg Arg Ala Gly Glu Arg Arg 
    290                 295                 300                 


Cys Pro Ala Met Ala Pro Arg Ala Arg Ser Ala Ser Gln Asp Arg Leu 
305                 310                 315                 320 


Glu Glu Val Ala Ala Pro Arg Pro Trp Pro Cys Ser Thr Ser Gln Asp 
                325                 330                 335     


Ala Leu Ser Gln Leu Gly Gln Glu Gly Trp His Arg Ala Arg Ser Asp 
            340                 345                 350         


Asp Tyr Leu Ser Arg Ala Thr Arg Ser Ala Glu Ala Leu Gly Pro Gly 
        355                 360                 365             


Ala Leu Val Ser Pro Arg Phe Glu Arg Cys Gly Trp Ala Ser Gln Arg 
    370                 375                 380                 


Ser Ser Ala Arg Thr Pro Ala Cys Pro Thr Arg Asp Leu Pro Gly Pro 
385                 390                 395                 400 


Gln Ala Pro Pro Pro Ser Gly Leu Gln Gly Leu Asp Asp Leu Gly Tyr 
                405                 410                 415     


Ile Gly Tyr Arg Ser Tyr Ser Pro Ser Phe Gln Arg Arg Thr Gly Leu 
            420                 425                 430         


Leu His Ala Leu Ser Phe Arg Asp Ser Pro Phe Gly Gly Leu Pro Thr 
        435                 440                 445             


Phe Asn Leu Ala Gln Ser Pro Ala Ser Phe Pro Pro Glu Ala Ser Glu 
    450                 455                 460                 


Pro Pro Arg Val Val Arg Pro Glu Pro Ser Thr Arg Ala Leu Glu Pro 
465                 470                 475                 480 


Pro Ala Glu Asp Arg Gly Asp Glu Val Val Leu Arg Gln Lys Pro Pro 
                485                 490                 495     


Thr Gly Arg Lys Val Gln Leu Thr Pro Ala Arg Gln Met Asn Leu Gly 
            500                 505                 510         


Phe Gly Asp Glu Ser Pro Glu Pro Glu Ala Ser Gly Arg Gly Glu Arg 
        515                 520                 525             


Leu Gly Arg Lys Val Ala Pro Leu Ala Thr Thr Glu Asp Ser Leu Ala 
    530                 535                 540                 


Ser Ile Pro Phe Ile Asp Glu Pro Thr Ser Pro Ser Ile Asp Leu Gln 
545                 550                 555                 560 


Ala Lys His Val Pro Ala Ser Ala Val Val Ser Ser Ala Met Asn Ser 
                565                 570                 575     


Ala Pro Val Leu Gly Thr Ser Pro Ser Ser Pro Thr Phe Thr Phe Thr 
            580                 585                 590         


Leu Gly Arg His Tyr Ser Gln Asp Cys Ser Ser Ile Lys Ala Gly Arg 
        595                 600                 605             


Arg Ser Ser Tyr Leu Leu Ala Ile Thr Thr Glu Arg Ser Lys Ser Cys 
    610                 615                 620                 


Asp Asp Gly Leu Asn Thr Phe Arg Asp Glu Gly Arg Val Leu Arg Arg 
625                 630                 635                 640 


Leu Pro Asn Arg Ile Pro Ser Leu Arg Met Leu Arg Ser Phe Phe Thr 
                645                 650                 655     


Asp Gly Ser Leu Asp Ser Trp Gly Thr Ser Glu Asp Ala Asp Ala Pro 
            660                 665                 670         


Ser Lys Arg His Ser Thr Ser Asp Leu Ser Asp Ala Thr Phe Ser Asp 
        675                 680                 685             


Ile Arg Arg Glu Gly Trp Leu Tyr Tyr Lys Gln Ile Leu Thr Lys Lys 
    690                 695                 700                 


Gly Lys Lys Ala Gly Ser Gly Leu Arg Gln Trp Lys Arg Val Tyr Ala 
705                 710                 715                 720 


Ala Leu Arg Ala Arg Ser Leu Ser Leu Ser Lys Glu Arg Arg Glu Pro 
                725                 730                 735     


Gly Pro Ala Ala Ala Gly Ala Ala Ala Ala Gly Ala Gly Glu Asp Glu 
            740                 745                 750         


Ala Ala Pro Val Cys Ile Gly Ser Cys Leu Val Asp Ile Ser Tyr Ser 
        755                 760                 765             


Glu Thr Lys Arg Arg His Val Phe Arg Leu Thr Thr Ala Asp Phe Cys 
    770                 775                 780                 


Glu Tyr Leu Phe Gln Ala Glu Asp Arg Asp Asp Met Leu Gly Trp Ile 
785                 790                 795                 800 


Arg Ala Ile Arg Glu Asn Ser Arg Ala Glu Gly Glu Asp Pro Gly Cys 
                805                 810                 815     


Ala Asn Gln Ala Leu Ile Ser Lys Lys Leu Asn Asp Tyr Arg Lys Val 
            820                 825                 830         


Ser His Ser Ser Gly Pro Lys Ala Asp Ser Ser Pro Lys Gly Ser Arg 
        835                 840                 845             


Gly Leu Gly Gly Leu Lys Ser Glu Phe Leu Lys Gln Ser Ala Ala Arg 
    850                 855                 860                 


Gly Leu Arg Thr Gln Asp Leu Pro Ala Gly Ser Lys Asp Asp Ser Ala 
865                 870                 875                 880 


Ala Ala Pro Lys Thr Pro Trp Gly Ile Asn Ile Ile Lys Lys Asn Lys 
                885                 890                 895     


Lys Ala Ala Pro Arg Ala Phe Gly Val Arg Leu Glu Glu Cys Gln Pro 
            900                 905                 910         


Ala Thr Glu Asn Gln Arg Val Pro Leu Ile Val Ala Ala Cys Cys Arg 
        915                 920                 925             


Ile Val Glu Ala Arg Gly Leu Glu Ser Thr Gly Ile Tyr Arg Val Pro 
    930                 935                 940                 


Gly Asn Asn Ala Val Val Ser Ser Leu Gln Glu Gln Leu Asn Arg Gly 
945                 950                 955                 960 


Pro Gly Asp Ile Asn Leu Gln Asp Glu Arg Trp Gln Asp Leu Asn Val 
                965                 970                 975     


Ile Ser Ser Leu Leu Lys Ser Phe Phe Arg Lys Leu Pro Glu Pro Leu 
            980                 985                 990         


Phe Thr Asp Asp Lys Tyr Asn Asp  Phe Ile Glu Ala Asn  Arg Ile Glu 
        995                 1000                 1005             


Asp Ala  Arg Glu Arg Met Arg  Thr Leu Arg Lys Leu  Ile Arg Asp 
    1010                 1015                 1020             


Leu Pro  Gly His Tyr Tyr Glu  Thr Leu Lys Phe Leu  Val Gly His 
    1025                 1030                 1035             


Leu Lys  Thr Ile Ala Asp His  Ser Glu Lys Asn Lys  Met Glu Pro 
    1040                 1045                 1050             


Arg Asn  Leu Ala Leu Val Phe  Gly Pro Thr Leu Val  Arg Thr Ser 
    1055                 1060                 1065             


Glu Asp  Asn Met Thr Asp Met  Val Thr His Met Pro  Asp Arg Tyr 
    1070                 1075                 1080             


Lys Ile  Val Glu Thr Leu Ile  Gln His Ser Asp Trp  Phe Phe Ser 
    1085                 1090                 1095             


Asp Glu  Glu Asp Lys Gly Glu  Arg Thr Pro Val Gly  Asp Lys Glu 
    1100                 1105                 1110             


Pro Gln  Ala Val Pro Asn Ile  Glu Tyr Leu Leu Pro  Asn Ile Gly 
    1115                 1120                 1125             


Arg Thr  Val Pro Pro Gly Asp  Pro Gly Ser Asp Ser  Thr Thr Cys 
    1130                 1135                 1140             


Ser Ser  Ala Lys Ser Lys Gly  Ser Trp Ala Pro Lys  Lys Glu Pro 
    1145                 1150                 1155             


Tyr Ala  Arg Glu Met Leu Ala  Ile Ser Phe Ile Ser  Ala Val Asn 
    1160                 1165                 1170             


Arg Lys  Arg Lys Lys Arg Arg  Glu Ala Arg Gly Leu  Gly Ser Ser 
    1175                 1180                 1185             


Thr Asp  Asp Asp Ser Glu Gln  Glu Ala His Lys Pro  Gly Ala Gly 
    1190                 1195                 1200             


Ala Thr  Ala Pro Gly Thr Gln  Glu Arg Pro Gln Gly  Pro Leu Pro 
    1205                 1210                 1215             


Gly Ala  Val Ala Pro Glu Ala  Pro Gly Arg Leu Ser  Pro Pro Ala 
    1220                 1225                 1230             


Ala Pro  Glu Glu Arg Pro Ala  Ala Asp Thr Arg Ser  Ile Val Ser 
    1235                 1240                 1245             


Gly Tyr  Ser Thr Leu Ser Thr  Met Asp Arg Ser Val  Cys Ser Gly 
    1250                 1255                 1260             


Ala Ser  Gly Arg Arg Ala Gly  Ala Gly Asp Glu Ala  Asp Asp Glu 
    1265                 1270                 1275             


Arg Ser  Glu Leu Ser His Val  Glu Thr Asp Thr Glu  Gly Ala Ala 
    1280                 1285                 1290             


Gly Ala  Gly Pro Gly Gly Arg  Leu Thr Arg Arg Pro  Ser Phe Ser 
    1295                 1300                 1305             


Ser His  His Leu Met Pro Cys  Asp Thr Leu Ala Arg  Arg Arg Leu 
    1310                 1315                 1320             


Ala Arg  Gly Arg Pro Asp Gly  Glu Gly Ala Gly Arg  Gly Gly Pro 
    1325                 1330                 1335             


Arg Ala  Pro Glu Pro Pro Gly  Ser Ala Ser Ser Ser  Ser Gln Glu 
    1340                 1345                 1350             


Ser Leu  Arg Pro Pro Ala Ala  Ala Leu Ala Ser Arg  Pro Ser Arg 
    1355                 1360                 1365             


Met Glu  Ala Leu Arg Leu Arg  Leu Arg Gly Thr Ala  Asp Asp Met 
    1370                 1375                 1380             


Leu Ala  Val Arg Leu Arg Arg  Pro Leu Ser Pro Glu  Thr Arg Arg 
    1385                 1390                 1395             


Arg Arg  Ser Ser Trp Arg Arg  His Thr Val Val Val  Gln Ser Pro 
    1400                 1405                 1410             


Leu Thr  Asp Leu Asn Phe Asn  Glu Trp Lys Glu Leu  Gly Gly Gly 
    1415                 1420                 1425             


Gly Pro  Pro Glu Pro Ala Gly  Ala Arg Ala His Ser  Asp Asn Lys 
    1430                 1435                 1440             


Asp Ser  Gly Leu Ser Ser Leu  Glu Ser Thr Lys Ala  Arg Ala Pro 
    1445                 1450                 1455             


Ser Ser  Ala Ala Ser Gln Pro  Pro Ala Pro Gly Asp  Thr Gly Ser 
    1460                 1465                 1470             


Leu Gln  Ser Gln Pro Pro Arg  Arg Ser Ala Ala Ser  Arg Leu His 
    1475                 1480                 1485             


Gln Cys  Leu 
    1490     


<210>  12
<211>  520
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Cytoskeletal Keratin 78 type II

<220>
<221>  misc_feature
<223>  or Keratin, type II cytoskeletal 78 (KRT78)

<400>  12

Met Ser Leu Ser Pro Cys Arg Ala Gln Arg Gly Phe Ser Ala Arg Ser 
1               5                   10                  15      


Ala Cys Ser Ala Arg Ser Arg Gly Arg Ser Arg Gly Gly Phe Ser Ser 
            20                  25                  30          


Arg Gly Gly Phe Ser Ser Arg Ser Leu Asn Ser Phe Gly Gly Cys Leu 
        35                  40                  45              


Glu Gly Ser Arg Gly Ser Thr Trp Gly Ser Gly Gly Arg Leu Gly Val 
    50                  55                  60                  


Arg Phe Gly Glu Trp Ser Gly Gly Pro Gly Leu Ser Leu Cys Pro Pro 
65                  70                  75                  80  


Gly Gly Ile Gln Glu Val Thr Ile Asn Gln Asn Leu Leu Thr Pro Leu 
                85                  90                  95      


Lys Ile Glu Ile Asp Pro Gln Phe Gln Val Val Arg Thr Gln Glu Thr 
            100                 105                 110         


Gln Glu Ile Arg Thr Leu Asn Asn Gln Phe Ala Ser Phe Ile Asp Lys 
        115                 120                 125             


Val Arg Phe Leu Glu Gln Gln Asn Lys Val Leu Glu Thr Lys Trp His 
    130                 135                 140                 


Leu Leu Gln Gln Gln Gly Leu Ser Gly Ser Gln Gln Gly Leu Glu Pro 
145                 150                 155                 160 


Val Phe Glu Ala Cys Leu Asp Gln Leu Arg Lys Gln Leu Glu Gln Leu 
                165                 170                 175     


Gln Gly Glu Arg Gly Ala Leu Asp Ala Glu Leu Lys Ala Cys Arg Asp 
            180                 185                 190         


Gln Glu Glu Glu Tyr Lys Ser Lys Tyr Glu Glu Glu Ala His Arg Arg 
        195                 200                 205             


Ala Thr Leu Glu Asn Asp Phe Val Val Leu Lys Lys Asp Val Asp Gly 
    210                 215                 220                 


Val Phe Leu Ser Lys Met Glu Leu Glu Gly Lys Leu Glu Ala Leu Arg 
225                 230                 235                 240 


Glu Tyr Leu Tyr Phe Leu Lys His Leu Asn Glu Glu Glu Leu Gly Gln 
                245                 250                 255     


Leu Gln Thr Gln Ala Ser Asp Thr Ser Val Val Leu Ser Met Asp Asn 
            260                 265                 270         


Asn Arg Tyr Leu Asp Phe Ser Ser Ile Ile Thr Glu Val Arg Ala Arg 
        275                 280                 285             


Tyr Glu Glu Ile Ala Arg Ser Ser Lys Ala Glu Ala Glu Ala Leu Tyr 
    290                 295                 300                 


Gln Thr Lys Tyr Gln Glu Leu Gln Val Ser Ala Gln Leu His Gly Asp 
305                 310                 315                 320 


Arg Met Gln Glu Thr Lys Val Gln Ile Ser Gln Leu His Gln Glu Ile 
                325                 330                 335     


Gln Arg Leu Gln Ser Gln Thr Glu Asn Leu Lys Lys Gln Asn Ala Ser 
            340                 345                 350         


Leu Gln Ala Ala Ile Thr Asp Ala Glu Gln Arg Gly Glu Leu Ala Leu 
        355                 360                 365             


Lys Asp Ala Gln Ala Lys Val Asp Glu Leu Glu Ala Ala Leu Arg Met 
    370                 375                 380                 


Ala Lys Gln Asn Leu Ala Arg Leu Leu Cys Glu Tyr Gln Glu Leu Thr 
385                 390                 395                 400 


Ser Thr Lys Leu Ser Leu Asp Val Glu Ile Ala Thr Tyr Arg Arg Leu 
                405                 410                 415     


Leu Glu Gly Glu Glu Cys Arg Met Ser Gly Glu Cys Thr Ser Gln Val 
            420                 425                 430         


Thr Ile Ser Ser Val Gly Gly Ser Ala Val Met Ser Gly Gly Val Gly 
        435                 440                 445             


Gly Gly Leu Gly Ser Thr Cys Gly Leu Gly Ser Gly Lys Gly Ser Pro 
    450                 455                 460                 


Gly Ser Cys Cys Thr Ser Ile Val Thr Gly Gly Ser Asn Ile Ile Leu 
465                 470                 475                 480 


Gly Ser Gly Lys Asp Pro Val Leu Asp Ser Cys Ser Val Ser Gly Ser 
                485                 490                 495     


Ser Ala Gly Ser Ser Cys His Thr Ile Leu Lys Lys Thr Val Glu Ser 
            500                 505                 510         


Ser Leu Lys Thr Ser Ile Thr Tyr 
        515                 520 


<210>  13
<211>  3177
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Alpha-3 collagen chain (VI)

<220>
<221>  misc_feature
<223>  or Collagen type VI, alpha 3 (COL6A3)

<400>  13

Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe 
1               5                   10                  15      


Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Asp Val 
            20                  25                  30          


Lys Asn Gly Ala Ala Ala Asp Ile Ile Phe Leu Val Asp Ser Ser Trp 
        35                  40                  45              


Thr Ile Gly Glu Glu His Phe Gln Leu Val Arg Glu Phe Leu Tyr Asp 
    50                  55                  60                  


Val Val Lys Ser Leu Ala Val Gly Glu Asn Asp Phe His Phe Ala Leu 
65                  70                  75                  80  


Val Gln Phe Asn Gly Asn Pro His Thr Glu Phe Leu Leu Asn Thr Tyr 
                85                  90                  95      


Arg Thr Lys Gln Glu Val Leu Ser His Ile Ser Asn Met Ser Tyr Ile 
            100                 105                 110         


Gly Gly Thr Asn Gln Thr Gly Lys Gly Leu Glu Tyr Ile Met Gln Ser 
        115                 120                 125             


His Leu Thr Lys Ala Ala Gly Ser Arg Ala Gly Asp Gly Val Pro Gln 
    130                 135                 140                 


Val Ile Val Val Leu Thr Asp Gly His Ser Lys Asp Gly Leu Ala Leu 
145                 150                 155                 160 


Pro Ser Ala Glu Leu Lys Ser Ala Asp Val Asn Val Phe Ala Ile Gly 
                165                 170                 175     


Val Glu Asp Ala Asp Glu Gly Ala Leu Lys Glu Ile Ala Ser Glu Pro 
            180                 185                 190         


Leu Asn Met His Met Phe Asn Leu Glu Asn Phe Thr Ser Leu His Asp 
        195                 200                 205             


Ile Val Gly Asn Leu Val Ser Cys Val His Ser Ser Val Ser Pro Glu 
    210                 215                 220                 


Arg Ala Gly Asp Thr Glu Thr Leu Lys Asp Ile Thr Ala Gln Asp Ser 
225                 230                 235                 240 


Ala Asp Ile Ile Phe Leu Ile Asp Gly Ser Asn Asn Thr Gly Ser Val 
                245                 250                 255     


Asn Phe Ala Val Ile Leu Asp Phe Leu Val Asn Leu Leu Glu Lys Leu 
            260                 265                 270         


Pro Ile Gly Thr Gln Gln Ile Arg Val Gly Val Val Gln Phe Ser Asp 
        275                 280                 285             


Glu Pro Arg Thr Met Phe Ser Leu Asp Thr Tyr Ser Thr Lys Ala Gln 
    290                 295                 300                 


Val Leu Gly Ala Val Lys Ala Leu Gly Phe Ala Gly Gly Glu Leu Ala 
305                 310                 315                 320 


Asn Ile Gly Leu Ala Leu Asp Phe Val Val Glu Asn His Phe Thr Arg 
                325                 330                 335     


Ala Gly Gly Ser Arg Val Glu Glu Gly Val Pro Gln Val Leu Val Leu 
            340                 345                 350         


Ile Ser Ala Gly Pro Ser Ser Asp Glu Ile Arg Tyr Gly Val Val Ala 
        355                 360                 365             


Leu Lys Gln Ala Ser Val Phe Ser Phe Gly Leu Gly Ala Gln Ala Ala 
    370                 375                 380                 


Ser Arg Ala Glu Leu Gln His Ile Ala Thr Asp Asp Asn Leu Val Phe 
385                 390                 395                 400 


Thr Val Pro Glu Phe Arg Ser Phe Gly Asp Leu Gln Glu Lys Leu Leu 
                405                 410                 415     


Pro Tyr Ile Val Gly Val Ala Gln Arg His Ile Val Leu Lys Pro Pro 
            420                 425                 430         


Thr Ile Val Thr Gln Val Ile Glu Val Asn Lys Arg Asp Ile Val Phe 
        435                 440                 445             


Leu Val Asp Gly Ser Ser Ala Leu Gly Leu Ala Asn Phe Asn Ala Ile 
    450                 455                 460                 


Arg Asp Phe Ile Ala Lys Val Ile Gln Arg Leu Glu Ile Gly Gln Asp 
465                 470                 475                 480 


Leu Ile Gln Val Ala Val Ala Gln Tyr Ala Asp Thr Val Arg Pro Glu 
                485                 490                 495     


Phe Tyr Phe Asn Thr His Pro Thr Lys Arg Glu Val Ile Thr Ala Val 
            500                 505                 510         


Arg Lys Met Lys Pro Leu Asp Gly Ser Ala Leu Tyr Thr Gly Ser Ala 
        515                 520                 525             


Leu Asp Phe Val Arg Asn Asn Leu Phe Thr Ser Ser Ala Gly Tyr Arg 
    530                 535                 540                 


Ala Ala Glu Gly Ile Pro Lys Leu Leu Val Leu Ile Thr Gly Gly Lys 
545                 550                 555                 560 


Ser Leu Asp Glu Ile Ser Gln Pro Ala Gln Glu Leu Lys Arg Ser Ser 
                565                 570                 575     


Ile Met Ala Phe Ala Ile Gly Asn Lys Gly Ala Asp Gln Ala Glu Leu 
            580                 585                 590         


Glu Glu Ile Ala Phe Asp Ser Ser Leu Val Phe Ile Pro Ala Glu Phe 
        595                 600                 605             


Arg Ala Ala Pro Leu Gln Gly Met Leu Pro Gly Leu Leu Ala Pro Leu 
    610                 615                 620                 


Arg Thr Leu Ser Gly Thr Pro Glu Val His Ser Asn Lys Arg Asp Ile 
625                 630                 635                 640 


Ile Phe Leu Leu Asp Gly Ser Ala Asn Val Gly Lys Thr Asn Phe Pro 
                645                 650                 655     


Tyr Val Arg Asp Phe Val Met Asn Leu Val Asn Ser Leu Asp Ile Gly 
            660                 665                 670         


Asn Asp Asn Ile Arg Val Gly Leu Val Gln Phe Ser Asp Thr Pro Val 
        675                 680                 685             


Thr Glu Phe Ser Leu Asn Thr Tyr Gln Thr Lys Ser Asp Ile Leu Gly 
    690                 695                 700                 


His Leu Arg Gln Leu Gln Leu Gln Gly Gly Ser Gly Leu Asn Thr Gly 
705                 710                 715                 720 


Ser Ala Leu Ser Tyr Val Tyr Ala Asn His Phe Thr Glu Ala Gly Gly 
                725                 730                 735     


Ser Arg Ile Arg Glu His Val Pro Gln Leu Leu Leu Leu Leu Thr Ala 
            740                 745                 750         


Gly Gln Ser Glu Asp Ser Tyr Leu Gln Ala Ala Asn Ala Leu Thr Arg 
        755                 760                 765             


Ala Gly Ile Leu Thr Phe Cys Val Gly Ala Ser Gln Ala Asn Lys Ala 
    770                 775                 780                 


Glu Leu Glu Gln Ile Ala Phe Asn Pro Ser Leu Val Tyr Leu Met Asp 
785                 790                 795                 800 


Asp Phe Ser Ser Leu Pro Ala Leu Pro Gln Gln Leu Ile Gln Pro Leu 
                805                 810                 815     


Thr Thr Tyr Val Ser Gly Gly Val Glu Glu Val Pro Leu Ala Gln Pro 
            820                 825                 830         


Glu Ser Lys Arg Asp Ile Leu Phe Leu Phe Asp Gly Ser Ala Asn Leu 
        835                 840                 845             


Val Gly Gln Phe Pro Val Val Arg Asp Phe Leu Tyr Lys Ile Ile Asp 
    850                 855                 860                 


Glu Leu Asn Val Lys Pro Glu Gly Thr Arg Ile Ala Val Ala Gln Tyr 
865                 870                 875                 880 


Ser Asp Asp Val Lys Val Glu Ser Arg Phe Asp Glu His Gln Ser Lys 
                885                 890                 895     


Pro Glu Ile Leu Asn Leu Val Lys Arg Met Lys Ile Lys Thr Gly Lys 
            900                 905                 910         


Ala Leu Asn Leu Gly Tyr Ala Leu Asp Tyr Ala Gln Arg Tyr Ile Phe 
        915                 920                 925             


Val Lys Ser Ala Gly Ser Arg Ile Glu Asp Gly Val Leu Gln Phe Leu 
    930                 935                 940                 


Val Leu Leu Val Ala Gly Arg Ser Ser Asp Arg Val Asp Gly Pro Ala 
945                 950                 955                 960 


Ser Asn Leu Lys Gln Ser Gly Val Val Pro Phe Ile Phe Gln Ala Lys 
                965                 970                 975     


Asn Ala Asp Pro Ala Glu Leu Glu Gln Ile Val Leu Ser Pro Ala Phe 
            980                 985                 990         


Ile Leu Ala Ala Glu Ser Leu Pro  Lys Ile Gly Asp Leu  His Pro Gln 
        995                 1000                 1005             


Ile Val  Asn Leu Leu Lys Ser  Val His Asn Gly Ala  Pro Ala Pro 
    1010                 1015                 1020             


Val Ser  Gly Glu Lys Asp Val  Val Phe Leu Leu Asp  Gly Ser Glu 
    1025                 1030                 1035             


Gly Val  Arg Ser Gly Phe Pro  Leu Leu Lys Glu Phe  Val Gln Arg 
    1040                 1045                 1050             


Val Val  Glu Ser Leu Asp Val  Gly Gln Asp Arg Val  Arg Val Ala 
    1055                 1060                 1065             


Val Val  Gln Tyr Ser Asp Arg  Thr Arg Pro Glu Phe  Tyr Leu Asn 
    1070                 1075                 1080             


Ser Tyr  Met Asn Lys Gln Asp  Val Val Asn Ala Val  Arg Gln Leu 
    1085                 1090                 1095             


Thr Leu  Leu Gly Gly Pro Thr  Pro Asn Thr Gly Ala  Ala Leu Glu 
    1100                 1105                 1110             


Phe Val  Leu Arg Asn Ile Leu  Val Ser Ser Ala Gly  Ser Arg Ile 
    1115                 1120                 1125             


Thr Glu  Gly Val Pro Gln Leu  Leu Ile Val Leu Thr  Ala Asp Arg 
    1130                 1135                 1140             


Ser Gly  Asp Asp Val Arg Asn  Pro Ser Val Val Val  Lys Arg Gly 
    1145                 1150                 1155             


Gly Ala  Val Pro Ile Gly Ile  Gly Ile Gly Asn Ala  Asp Ile Thr 
    1160                 1165                 1170             


Glu Met  Gln Thr Ile Ser Phe  Ile Pro Asp Phe Ala  Val Ala Ile 
    1175                 1180                 1185             


Pro Thr  Phe Arg Gln Leu Gly  Thr Val Gln Gln Val  Ile Ser Glu 
    1190                 1195                 1200             


Arg Val  Thr Gln Leu Thr Arg  Glu Glu Leu Ser Arg  Leu Gln Pro 
    1205                 1210                 1215             


Val Leu  Gln Pro Leu Pro Ser  Pro Gly Val Gly Gly  Lys Arg Asp 
    1220                 1225                 1230             


Val Val  Phe Leu Ile Asp Gly  Ser Gln Ser Ala Gly  Pro Glu Phe 
    1235                 1240                 1245             


Gln Tyr  Val Arg Thr Leu Ile  Glu Arg Leu Val Asp  Tyr Leu Asp 
    1250                 1255                 1260             


Val Gly  Phe Asp Thr Thr Arg  Val Ala Val Ile Gln  Phe Ser Asp 
    1265                 1270                 1275             


Asp Pro  Lys Val Glu Phe Leu  Leu Asn Ala His Ser  Ser Lys Asp 
    1280                 1285                 1290             


Glu Val  Gln Asn Ala Val Gln  Arg Leu Arg Pro Lys  Gly Gly Arg 
    1295                 1300                 1305             


Gln Ile  Asn Val Gly Asn Ala  Leu Glu Tyr Val Ser  Arg Asn Ile 
    1310                 1315                 1320             


Phe Lys  Arg Pro Leu Gly Ser  Arg Ile Glu Glu Gly  Val Pro Gln 
    1325                 1330                 1335             


Phe Leu  Val Leu Ile Ser Ser  Gly Lys Ser Asp Asp  Glu Val Asp 
    1340                 1345                 1350             


Asp Pro  Ala Val Glu Leu Lys  Gln Phe Gly Val Ala  Pro Phe Thr 
    1355                 1360                 1365             


Ile Ala  Arg Asn Ala Asp Gln  Glu Glu Leu Val Lys  Ile Ser Leu 
    1370                 1375                 1380             


Ser Pro  Glu Tyr Val Phe Ser  Val Ser Thr Phe Arg  Glu Leu Pro 
    1385                 1390                 1395             


Ser Leu  Glu Gln Lys Leu Leu  Thr Pro Ile Thr Thr  Leu Thr Ser 
    1400                 1405                 1410             


Glu Gln  Ile Gln Lys Leu Leu  Ala Ser Thr Arg Tyr  Pro Pro Pro 
    1415                 1420                 1425             


Ala Val  Glu Ser Asp Ala Ala  Asp Ile Val Phe Leu  Ile Asp Ser 
    1430                 1435                 1440             


Ser Glu  Gly Val Arg Pro Asp  Gly Phe Ala His Ile  Arg Asp Phe 
    1445                 1450                 1455             


Val Ser  Arg Ile Val Arg Arg  Leu Asn Ile Gly Pro  Ser Lys Val 
    1460                 1465                 1470             


Arg Val  Gly Val Val Gln Phe  Ser Asn Asp Val Phe  Pro Glu Phe 
    1475                 1480                 1485             


Tyr Leu  Lys Thr Tyr Arg Ser  Gln Ala Pro Val Leu  Asp Ala Ile 
    1490                 1495                 1500             


Arg Arg  Leu Arg Leu Arg Gly  Gly Ser Pro Leu Asn  Thr Gly Lys 
    1505                 1510                 1515             


Ala Leu  Glu Phe Val Ala Arg  Asn Leu Phe Val Lys  Ser Ala Gly 
    1520                 1525                 1530             


Ser Arg  Ile Glu Asp Gly Val  Pro Gln His Leu Val  Leu Val Leu 
    1535                 1540                 1545             


Gly Gly  Lys Ser Gln Asp Asp  Val Ser Arg Phe Ala  Gln Val Ile 
    1550                 1555                 1560             


Arg Ser  Ser Gly Ile Val Ser  Leu Gly Val Gly Asp  Arg Asn Ile 
    1565                 1570                 1575             


Asp Arg  Thr Glu Leu Gln Thr  Ile Thr Asn Asp Pro  Arg Leu Val 
    1580                 1585                 1590             


Phe Thr  Val Arg Glu Phe Arg  Glu Leu Pro Asn Ile  Glu Glu Arg 
    1595                 1600                 1605             


Ile Met  Asn Ser Phe Gly Pro  Ser Ala Ala Thr Pro  Ala Pro Pro 
    1610                 1615                 1620             


Gly Val  Asp Thr Pro Pro Pro  Ser Arg Pro Glu Lys  Lys Lys Ala 
    1625                 1630                 1635             


Asp Ile  Val Phe Leu Leu Asp  Gly Ser Ile Asn Phe  Arg Arg Asp 
    1640                 1645                 1650             


Ser Phe  Gln Glu Val Leu Arg  Phe Val Ser Glu Ile  Val Asp Thr 
    1655                 1660                 1665             


Val Tyr  Glu Asp Gly Asp Ser  Ile Gln Val Gly Leu  Val Gln Tyr 
    1670                 1675                 1680             


Asn Ser  Asp Pro Thr Asp Glu  Phe Phe Leu Lys Asp  Phe Ser Thr 
    1685                 1690                 1695             


Lys Arg  Gln Ile Ile Asp Ala  Ile Asn Lys Val Val  Tyr Lys Gly 
    1700                 1705                 1710             


Gly Arg  His Ala Asn Thr Lys  Val Gly Leu Glu His  Leu Arg Val 
    1715                 1720                 1725             


Asn His  Phe Val Pro Glu Ala  Gly Ser Arg Leu Asp  Gln Arg Val 
    1730                 1735                 1740             


Pro Gln  Ile Ala Phe Val Ile  Thr Gly Gly Lys Ser  Val Glu Asp 
    1745                 1750                 1755             


Ala Gln  Asp Val Ser Leu Ala  Leu Thr Gln Arg Gly  Val Lys Val 
    1760                 1765                 1770             


Phe Ala  Val Gly Val Arg Asn  Ile Asp Ser Glu Glu  Val Gly Lys 
    1775                 1780                 1785             


Ile Ala  Ser Asn Ser Ala Thr  Ala Phe Arg Val Gly  Asn Val Gln 
    1790                 1795                 1800             


Glu Leu  Ser Glu Leu Ser Glu  Gln Val Leu Glu Thr  Leu His Asp 
    1805                 1810                 1815             


Ala Met  His Glu Thr Leu Cys  Pro Gly Val Thr Asp  Ala Ala Lys 
    1820                 1825                 1830             


Ala Cys  Asn Leu Asp Val Ile  Leu Gly Phe Asp Gly  Ser Arg Asp 
    1835                 1840                 1845             


Gln Asn  Val Phe Val Ala Gln  Lys Gly Phe Glu Ser  Lys Val Asp 
    1850                 1855                 1860             


Ala Ile  Leu Asn Arg Ile Ser  Gln Met His Arg Val  Ser Cys Ser 
    1865                 1870                 1875             


Gly Gly  Arg Ser Pro Thr Val  Arg Val Ser Val Val  Ala Asn Thr 
    1880                 1885                 1890             


Pro Ser  Gly Pro Val Glu Ala  Phe Asp Phe Asp Glu  Tyr Gln Pro 
    1895                 1900                 1905             


Glu Met  Leu Glu Lys Phe Arg  Asn Met Arg Ser Gln  His Pro Tyr 
    1910                 1915                 1920             


Val Leu  Thr Glu Asp Thr Leu  Lys Val Tyr Leu Asn  Lys Phe Arg 
    1925                 1930                 1935             


Gln Ser  Ser Pro Asp Ser Val  Lys Val Val Ile His  Phe Thr Asp 
    1940                 1945                 1950             


Gly Ala  Asp Gly Asp Leu Ala  Asp Leu His Arg Ala  Ser Glu Asn 
    1955                 1960                 1965             


Leu Arg  Gln Glu Gly Val Arg  Ala Leu Ile Leu Val  Gly Leu Glu 
    1970                 1975                 1980             


Arg Val  Val Asn Leu Glu Arg  Leu Met His Leu Glu  Phe Gly Arg 
    1985                 1990                 1995             


Gly Phe  Met Tyr Asp Arg Pro  Leu Arg Leu Asn Leu  Leu Asp Leu 
    2000                 2005                 2010             


Asp Tyr  Glu Leu Ala Glu Gln  Leu Asp Asn Ile Ala  Glu Lys Ala 
    2015                 2020                 2025             


Cys Cys  Gly Val Pro Cys Lys  Cys Ser Gly Gln Arg  Gly Asp Arg 
    2030                 2035                 2040             


Gly Pro  Ile Gly Ser Ile Gly  Pro Lys Gly Ile Pro  Gly Glu Asp 
    2045                 2050                 2055             


Gly Tyr  Arg Gly Tyr Pro Gly  Asp Glu Gly Gly Pro  Gly Glu Arg 
    2060                 2065                 2070             


Gly Pro  Pro Gly Val Asn Gly  Thr Gln Gly Phe Gln  Gly Cys Pro 
    2075                 2080                 2085             


Gly Gln  Arg Gly Val Lys Gly  Ser Arg Gly Phe Pro  Gly Glu Lys 
    2090                 2095                 2100             


Gly Glu  Val Gly Glu Ile Gly  Leu Asp Gly Leu Asp  Gly Glu Asp 
    2105                 2110                 2115             


Gly Asp  Lys Gly Leu Pro Gly  Ser Ser Gly Glu Lys  Gly Asn Pro 
    2120                 2125                 2130             


Gly Arg  Arg Gly Asp Lys Gly  Pro Arg Gly Glu Lys  Gly Glu Arg 
    2135                 2140                 2145             


Gly Asp  Val Gly Ile Arg Gly  Asp Pro Gly Asn Pro  Gly Gln Asp 
    2150                 2155                 2160             


Ser Gln  Glu Arg Gly Pro Lys  Gly Glu Thr Gly Asp  Leu Gly Pro 
    2165                 2170                 2175             


Met Gly  Val Pro Gly Arg Asp  Gly Val Pro Gly Gly  Pro Gly Glu 
    2180                 2185                 2190             


Thr Gly  Lys Asn Gly Gly Phe  Gly Arg Arg Gly Pro  Pro Gly Ala 
    2195                 2200                 2205             


Lys Gly  Asn Lys Gly Gly Pro  Gly Gln Pro Gly Phe  Glu Gly Glu 
    2210                 2215                 2220             


Gln Gly  Thr Arg Gly Ala Gln  Gly Pro Ala Gly Pro  Ala Gly Pro 
    2225                 2230                 2235             


Pro Gly  Leu Ile Gly Glu Gln  Gly Ile Ser Gly Pro  Arg Gly Ser 
    2240                 2245                 2250             


Gly Gly  Ala Ala Gly Ala Pro  Gly Glu Arg Gly Arg  Thr Gly Pro 
    2255                 2260                 2265             


Leu Gly  Arg Lys Gly Glu Pro  Gly Glu Pro Gly Pro  Lys Gly Gly 
    2270                 2275                 2280             


Ile Gly  Asn Arg Gly Pro Arg  Gly Glu Thr Gly Asp  Asp Gly Arg 
    2285                 2290                 2295             


Asp Gly  Val Gly Ser Glu Gly  Arg Arg Gly Lys Lys  Gly Glu Arg 
    2300                 2305                 2310             


Gly Phe  Pro Gly Tyr Pro Gly  Pro Lys Gly Asn Pro  Gly Glu Pro 
    2315                 2320                 2325             


Gly Leu  Asn Gly Thr Thr Gly  Pro Lys Gly Ile Arg  Gly Arg Arg 
    2330                 2335                 2340             


Gly Asn  Ser Gly Pro Pro Gly  Ile Val Gly Gln Lys  Gly Asp Pro 
    2345                 2350                 2355             


Gly Tyr  Pro Gly Pro Ala Gly  Pro Lys Gly Asn Arg  Gly Asp Ser 
    2360                 2365                 2370             


Ile Asp  Gln Cys Ala Leu Ile  Gln Ser Ile Lys Asp  Lys Cys Pro 
    2375                 2380                 2385             


Cys Cys  Tyr Gly Pro Leu Glu  Cys Pro Val Phe Pro  Thr Glu Leu 
    2390                 2395                 2400             


Ala Phe  Ala Leu Asp Thr Ser  Glu Gly Val Asn Gln  Asp Thr Phe 
    2405                 2410                 2415             


Gly Arg  Met Arg Asp Val Val  Leu Ser Ile Val Asn  Asp Leu Thr 
    2420                 2425                 2430             


Ile Ala  Glu Ser Asn Cys Pro  Arg Gly Ala Arg Val  Ala Val Val 
    2435                 2440                 2445             


Thr Tyr  Asn Asn Glu Val Thr  Thr Glu Ile Arg Phe  Ala Asp Ser 
    2450                 2455                 2460             


Lys Arg  Lys Ser Val Leu Leu  Asp Lys Ile Lys Asn  Leu Gln Val 
    2465                 2470                 2475             


Ala Leu  Thr Ser Lys Gln Gln  Ser Leu Glu Thr Ala  Met Ser Phe 
    2480                 2485                 2490             


Val Ala  Arg Asn Thr Phe Lys  Arg Val Arg Asn Gly  Phe Leu Met 
    2495                 2500                 2505             


Arg Lys  Val Ala Val Phe Phe  Ser Asn Thr Pro Thr  Arg Ala Ser 
    2510                 2515                 2520             


Pro Gln  Leu Arg Glu Ala Val  Leu Lys Leu Ser Asp  Ala Gly Ile 
    2525                 2530                 2535             


Thr Pro  Leu Phe Leu Thr Arg  Gln Glu Asp Arg Gln  Leu Ile Asn 
    2540                 2545                 2550             


Ala Leu  Gln Ile Asn Asn Thr  Ala Val Gly His Ala  Leu Val Leu 
    2555                 2560                 2565             


Pro Ala  Gly Arg Asp Leu Thr  Asp Phe Leu Glu Asn  Val Leu Thr 
    2570                 2575                 2580             


Cys His  Val Cys Leu Asp Ile  Cys Asn Ile Asp Pro  Ser Cys Gly 
    2585                 2590                 2595             


Phe Gly  Ser Trp Arg Pro Ser  Phe Arg Asp Arg Arg  Ala Ala Gly 
    2600                 2605                 2610             


Ser Asp  Val Asp Ile Asp Met  Ala Phe Ile Leu Asp  Ser Ala Glu 
    2615                 2620                 2625             


Thr Thr  Thr Leu Phe Gln Phe  Asn Glu Met Lys Lys  Tyr Ile Ala 
    2630                 2635                 2640             


Tyr Leu  Val Arg Gln Leu Asp  Met Ser Pro Asp Pro  Lys Ala Ser 
    2645                 2650                 2655             


Gln His  Phe Ala Arg Val Ala  Val Val Gln His Ala  Pro Ser Glu 
    2660                 2665                 2670             


Ser Val  Asp Asn Ala Ser Met  Pro Pro Val Lys Val  Glu Phe Ser 
    2675                 2680                 2685             


Leu Thr  Asp Tyr Gly Ser Lys  Glu Lys Leu Val Asp  Phe Leu Ser 
    2690                 2695                 2700             


Arg Gly  Met Thr Gln Leu Gln  Gly Thr Arg Ala Leu  Gly Ser Ala 
    2705                 2710                 2715             


Ile Glu  Tyr Thr Ile Glu Asn  Val Phe Glu Ser Ala  Pro Asn Pro 
    2720                 2725                 2730             


Arg Asp  Leu Lys Ile Val Val  Leu Met Leu Thr Gly  Glu Val Pro 
    2735                 2740                 2745             


Glu Gln  Gln Leu Glu Glu Ala  Gln Arg Val Ile Leu  Gln Ala Lys 
    2750                 2755                 2760             


Cys Lys  Gly Tyr Phe Phe Val  Val Leu Gly Ile Gly  Arg Lys Val 
    2765                 2770                 2775             


Asn Ile  Lys Glu Val Tyr Thr  Phe Ala Ser Glu Pro  Asn Asp Val 
    2780                 2785                 2790             


Phe Phe  Lys Leu Val Asp Lys  Ser Thr Glu Leu Asn  Glu Glu Pro 
    2795                 2800                 2805             


Leu Met  Arg Phe Gly Arg Leu  Leu Pro Ser Phe Val  Ser Ser Glu 
    2810                 2815                 2820             


Asn Ala  Phe Tyr Leu Ser Pro  Asp Ile Arg Lys Gln  Cys Asp Trp 
    2825                 2830                 2835             


Phe Gln  Gly Asp Gln Pro Thr  Lys Asn Leu Val Lys  Phe Gly His 
    2840                 2845                 2850             


Lys Gln  Val Asn Val Pro Asn  Asn Val Thr Ser Ser  Pro Thr Ser 
    2855                 2860                 2865             


Asn Pro  Val Thr Thr Thr Lys  Pro Val Thr Thr Thr  Lys Pro Val 
    2870                 2875                 2880             


Thr Thr  Thr Thr Lys Pro Val  Thr Thr Thr Thr Lys  Pro Val Thr 
    2885                 2890                 2895             


Ile Ile  Asn Gln Pro Ser Val  Lys Pro Ala Ala Ala  Lys Pro Ala 
    2900                 2905                 2910             


Pro Ala  Lys Pro Val Ala Ala  Lys Pro Val Ala Thr  Lys Met Ala 
    2915                 2920                 2925             


Thr Val  Arg Pro Pro Val Ala  Val Lys Pro Ala Thr  Ala Ala Lys 
    2930                 2935                 2940             


Pro Val  Ala Ala Lys Pro Ala  Ala Val Arg Pro Pro  Ala Ala Ala 
    2945                 2950                 2955             


Ala Ala  Lys Pro Val Ala Thr  Lys Pro Glu Val Pro  Arg Pro Gln 
    2960                 2965                 2970             


Ala Ala  Lys Pro Ala Ala Thr  Lys Pro Ala Thr Thr  Lys Pro Met 
    2975                 2980                 2985             


Val Lys  Met Ser Arg Glu Val  Gln Val Phe Glu Ile  Thr Glu Asn 
    2990                 2995                 3000             


Ser Ala  Lys Leu His Trp Glu  Arg Ala Glu Pro Pro  Gly Pro Tyr 
    3005                 3010                 3015             


Phe Tyr  Asp Leu Thr Val Thr  Ser Ala His Asp Gln  Ser Leu Val 
    3020                 3025                 3030             


Leu Lys  Gln Asn Leu Thr Val  Thr Asp Arg Val Ile  Gly Gly Leu 
    3035                 3040                 3045             


Leu Ala  Gly Gln Thr Tyr His  Val Ala Val Val Cys  Tyr Leu Arg 
    3050                 3055                 3060             


Ser Gln  Val Arg Ala Thr Tyr  His Gly Ser Phe Ser  Thr Lys Lys 
    3065                 3070                 3075             


Ser Gln  Pro Pro Pro Pro Gln  Pro Ala Arg Ser Ala  Ser Ser Ser 
    3080                 3085                 3090             


Thr Ile  Asn Leu Met Val Ser  Thr Glu Pro Leu Ala  Leu Thr Glu 
    3095                 3100                 3105             


Thr Asp  Ile Cys Lys Leu Pro  Lys Asp Glu Gly Thr  Cys Arg Asp 
    3110                 3115                 3120             


Phe Ile  Leu Lys Trp Tyr Tyr  Asp Pro Asn Thr Lys  Ser Cys Ala 
    3125                 3130                 3135             


Arg Phe  Trp Tyr Gly Gly Cys  Gly Gly Asn Glu Asn  Lys Phe Gly 
    3140                 3145                 3150             


Ser Gln  Lys Glu Cys Glu Lys  Val Cys Ala Pro Val  Leu Ala Lys 
    3155                 3160                 3165             


Pro Gly  Val Ile Ser Val Met  Gly Thr 
    3170                 3175         


<210>  14
<211>  263
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Beta subunit of proteasome type-5

<220>
<221>  misc_feature
<223>  or Proteasome subunit beta type-5 (PSMB5)

<400>  14

Met Ala Leu Ala Ser Val Leu Glu Arg Pro Leu Pro Val Asn Gln Arg 
1               5                   10                  15      


Gly Phe Phe Gly Leu Gly Gly Arg Ala Asp Leu Leu Asp Leu Gly Pro 
            20                  25                  30          


Gly Ser Leu Ser Asp Gly Leu Ser Leu Ala Ala Pro Gly Trp Gly Val 
        35                  40                  45              


Pro Glu Glu Pro Gly Ile Glu Met Leu His Gly Thr Thr Thr Leu Ala 
    50                  55                  60                  


Phe Lys Phe Arg His Gly Val Ile Val Ala Ala Asp Ser Arg Ala Thr 
65                  70                  75                  80  


Ala Gly Ala Tyr Ile Ala Ser Gln Thr Val Lys Lys Val Ile Glu Ile 
                85                  90                  95      


Asn Pro Tyr Leu Leu Gly Thr Met Ala Gly Gly Ala Ala Asp Cys Ser 
            100                 105                 110         


Phe Trp Glu Arg Leu Leu Ala Arg Gln Cys Arg Ile Tyr Glu Leu Arg 
        115                 120                 125             


Asn Lys Glu Arg Ile Ser Val Ala Ala Ala Ser Lys Leu Leu Ala Asn 
    130                 135                 140                 


Met Val Tyr Gln Tyr Lys Gly Met Gly Leu Ser Met Gly Thr Met Ile 
145                 150                 155                 160 


Cys Gly Trp Asp Lys Arg Gly Pro Gly Leu Tyr Tyr Val Asp Ser Glu 
                165                 170                 175     


Gly Asn Arg Ile Ser Gly Ala Thr Phe Ser Val Gly Ser Gly Ser Val 
            180                 185                 190         


Tyr Ala Tyr Gly Val Met Asp Arg Gly Tyr Ser Tyr Asp Leu Glu Val 
        195                 200                 205             


Glu Gln Ala Tyr Asp Leu Ala Arg Arg Ala Ile Tyr Gln Ala Thr Tyr 
    210                 215                 220                 


Arg Asp Ala Tyr Ser Gly Gly Ala Val Asn Leu Tyr His Val Arg Glu 
225                 230                 235                 240 


Asp Gly Trp Ile Arg Val Ser Ser Asp Asn Val Ala Asp Leu His Glu 
                245                 250                 255     


Lys Tyr Ser Gly Ser Thr Pro 
            260             


<210>  15
<211>  353
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)

<400>  15

Met Glu Lys Thr Leu Glu Thr Val Pro Leu Glu Arg Lys Lys Arg Glu 
1               5                   10                  15      


Lys Glu Gln Phe Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr 
            20                  25                  30          


Thr Glu Glu Ser Leu Arg Asn Tyr Tyr Glu Gln Trp Gly Lys Leu Thr 
        35                  40                  45              


Asp Cys Val Val Met Arg Asp Pro Ala Ser Lys Arg Ser Arg Gly Phe 
    50                  55                  60                  


Gly Phe Val Thr Phe Ser Ser Met Ala Glu Val Asp Ala Ala Met Ala 
65                  70                  75                  80  


Ala Arg Pro His Ser Ile Asp Gly Arg Val Val Glu Pro Lys Arg Ala 
                85                  90                  95      


Val Ala Arg Glu Glu Ser Gly Lys Pro Gly Ala His Val Thr Val Lys 
            100                 105                 110         


Lys Leu Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu His His Leu 
        115                 120                 125             


Arg Asp Tyr Phe Glu Glu Tyr Gly Lys Ile Asp Thr Ile Glu Ile Ile 
    130                 135                 140                 


Thr Asp Arg Gln Ser Gly Lys Lys Arg Gly Phe Gly Phe Val Thr Phe 
145                 150                 155                 160 


Asp Asp His Asp Pro Val Asp Lys Ile Val Leu Gln Lys Tyr His Thr 
                165                 170                 175     


Ile Asn Gly His Asn Ala Glu Val Arg Lys Ala Leu Ser Arg Gln Glu 
            180                 185                 190         


Met Gln Glu Val Gln Ser Ser Arg Ser Gly Arg Gly Gly Asn Phe Gly 
        195                 200                 205             


Phe Gly Asp Ser Arg Gly Gly Gly Gly Asn Phe Gly Pro Gly Pro Gly 
    210                 215                 220                 


Ser Asn Phe Arg Gly Gly Ser Asp Gly Tyr Gly Ser Gly Arg Gly Phe 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Tyr Gly Gly Gly Pro Gly Gly Gly Asn Phe 
                245                 250                 255     


Gly Gly Ser Pro Gly Tyr Gly Gly Gly Arg Gly Gly Tyr Gly Gly Gly 
            260                 265                 270         


Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly Gly Gly Tyr Asp 
        275                 280                 285             


Asn Tyr Gly Gly Gly Asn Tyr Gly Ser Gly Asn Tyr Asn Asp Phe Gly 
    290                 295                 300                 


Asn Tyr Asn Gln Gln Pro Ser Asn Tyr Gly Pro Met Lys Ser Gly Asn 
305                 310                 315                 320 


Phe Gly Gly Ser Arg Asn Met Gly Gly Pro Tyr Gly Gly Gly Asn Tyr 
                325                 330                 335     


Gly Pro Gly Gly Ser Gly Gly Ser Gly Gly Tyr Gly Gly Arg Ser Arg 
            340                 345                 350         


Tyr 
    


<210>  16
<211>  126
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Histone H2B type 1-B (HIST1H2BB)

<400>  16

Met Pro Glu Pro Ser Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys 
1               5                   10                  15      


Lys Ala Ile Thr Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg 
            20                  25                  30          


Ser Arg Lys Glu Ser Tyr Ser Ile Tyr Val Tyr Lys Val Leu Lys Gln 
        35                  40                  45              


Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn 
    50                  55                  60                  


Ser Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Glu Ala Ser Arg 
65                  70                  75                  80  


Leu Ala His Tyr Asn Lys Arg Ser Thr Ile Thr Ser Arg Glu Ile Gln 
                85                  90                  95      


Thr Ala Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val 
            100                 105                 110         


Ser Glu Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys 
        115                 120                 125     


<210>  17
<211>  2243
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  homolog of DnaJ subfamily C member 13

<220>
<221>  misc_feature
<223>  or DnaJ homolog subfamily C member 13 (DNAJC13)

<400>  17

Met Asn Ile Ile Arg Glu Asn Lys Asp Leu Ala Cys Phe Tyr Thr Thr 
1               5                   10                  15      


Lys His Ser Trp Arg Gly Lys Tyr Lys Arg Val Phe Ser Val Gly Thr 
            20                  25                  30          


His Ala Ile Thr Thr Tyr Asn Pro Asn Thr Leu Glu Val Thr Asn Gln 
        35                  40                  45              


Trp Pro Tyr Gly Asp Ile Cys Ser Ile Ser Pro Val Gly Lys Gly Gln 
    50                  55                  60                  


Gly Thr Glu Phe Asn Leu Thr Phe Arg Lys Gly Ser Gly Lys Lys Ser 
65                  70                  75                  80  


Glu Thr Leu Lys Phe Ser Thr Glu His Arg Thr Glu Leu Leu Thr Glu 
                85                  90                  95      


Ala Leu Arg Phe Arg Thr Asp Phe Ser Glu Gly Lys Ile Thr Gly Arg 
            100                 105                 110         


Arg Tyr Asn Cys Tyr Lys His His Trp Ser Asp Ser Arg Lys Pro Val 
        115                 120                 125             


Ile Leu Glu Val Thr Pro Gly Gly Phe Asp Gln Ile Asn Pro Ala Thr 
    130                 135                 140                 


Asn Arg Val Leu Cys Ser Tyr Asp Tyr Arg Asn Ile Glu Gly Phe Val 
145                 150                 155                 160 


Asp Leu Ser Asp Tyr Gln Gly Gly Phe Cys Ile Leu Tyr Gly Gly Phe 
                165                 170                 175     


Ser Arg Leu His Leu Phe Ala Ser Glu Gln Arg Glu Glu Ile Ile Lys 
            180                 185                 190         


Ser Ala Ile Asp His Ala Gly Asn Tyr Ile Gly Ile Ser Leu Arg Ile 
        195                 200                 205             


Arg Lys Glu Pro Leu Glu Phe Glu Gln Tyr Leu Asn Leu Arg Phe Gly 
    210                 215                 220                 


Lys Tyr Ser Thr Asp Glu Ser Ile Thr Ser Leu Ala Glu Phe Val Val 
225                 230                 235                 240 


Gln Lys Ile Ser Pro Arg His Ser Glu Pro Val Lys Arg Val Leu Ala 
                245                 250                 255     


Leu Thr Glu Thr Cys Leu Val Glu Arg Asp Pro Ala Thr Tyr Asn Ile 
            260                 265                 270         


Ala Thr Leu Lys Pro Leu Gly Glu Val Phe Ala Leu Val Cys Asp Ser 
        275                 280                 285             


Glu Asn Pro Gln Leu Phe Thr Ile Glu Phe Ile Lys Gly Gln Val Arg 
    290                 295                 300                 


Lys Tyr Ser Ser Thr Glu Arg Asp Ser Leu Leu Ala Ser Leu Leu Asp 
305                 310                 315                 320 


Gly Val Arg Ala Ser Gly Asn Arg Asp Val Cys Val Lys Met Thr Pro 
                325                 330                 335     


Thr His Lys Gly Gln Arg Trp Gly Leu Leu Ser Met Pro Val Asp Glu 
            340                 345                 350         


Glu Val Glu Ser Leu His Leu Arg Phe Leu Ala Thr Pro Pro Asn Gly 
        355                 360                 365             


Asn Phe Ala Asp Ala Val Phe Arg Phe Asn Ala Asn Ile Ser Tyr Ser 
    370                 375                 380                 


Gly Val Leu His Ala Val Thr Gln Asp Gly Leu Phe Ser Glu Asn Lys 
385                 390                 395                 400 


Glu Lys Leu Ile Asn Asn Ala Ile Thr Ala Leu Leu Ser Gln Glu Gly 
                405                 410                 415     


Asp Val Val Ala Ser Asn Ala Glu Leu Glu Ser Gln Phe Gln Ala Val 
            420                 425                 430         


Arg Arg Leu Val Ala Ser Lys Ala Gly Phe Leu Ala Phe Thr Gln Leu 
        435                 440                 445             


Pro Lys Phe Arg Glu Arg Leu Gly Val Lys Val Val Lys Ala Leu Lys 
    450                 455                 460                 


Arg Ser Asn Asn Gly Ile Ile His Ala Ala Val Asp Met Leu Cys Ala 
465                 470                 475                 480 


Leu Met Cys Pro Met His Asp Asp Tyr Asp Leu Arg Gln Glu Gln Leu 
                485                 490                 495     


Asn Lys Ala Ser Leu Leu Ser Ser Lys Lys Phe Leu Glu Asn Leu Leu 
            500                 505                 510         


Glu Lys Phe Asn Ser His Val Asp His Gly Thr Gly Ala Leu Val Ile 
        515                 520                 525             


Ser Ser Leu Leu Asp Phe Leu Thr Phe Ala Leu Cys Ala Pro Tyr Ser 
    530                 535                 540                 


Glu Thr Thr Glu Gly Gln Gln Phe Asp Met Leu Leu Glu Met Val Ala 
545                 550                 555                 560 


Ser Asn Gly Arg Thr Leu Phe Lys Leu Phe Gln His Pro Ser Met Ala 
                565                 570                 575     


Ile Ile Lys Gly Ala Gly Leu Val Met Lys Ala Ile Ile Glu Glu Gly 
            580                 585                 590         


Asp Lys Glu Ile Ala Thr Lys Met Gln Glu Leu Ala Leu Ser Glu Gly 
        595                 600                 605             


Ala Leu Pro Arg His Leu His Thr Ala Met Phe Thr Ile Ser Ser Asp 
    610                 615                 620                 


Gln Arg Met Leu Thr Asn Arg Gln Leu Ser Arg His Leu Val Gly Leu 
625                 630                 635                 640 


Trp Thr Ala Asp Asn Ala Thr Ala Thr Asn Leu Leu Lys Arg Ile Leu 
                645                 650                 655     


Pro Pro Gly Leu Leu Ala Tyr Leu Glu Ser Ser Asp Leu Val Pro Glu 
            660                 665                 670         


Lys Asp Ala Asp Arg Met His Val Arg Asp Asn Val Lys Ile Ala Met 
        675                 680                 685             


Asp Gln Tyr Gly Lys Phe Asn Lys Val Pro Glu Trp Gln Arg Leu Ala 
    690                 695                 700                 


Gly Lys Ala Ala Lys Glu Val Glu Lys Phe Ala Lys Glu Lys Val Asp 
705                 710                 715                 720 


Leu Val Leu Met His Trp Arg Asp Arg Met Gly Ile Ala Gln Lys Glu 
                725                 730                 735     


Asn Ile Asn Gln Lys Pro Val Val Leu Arg Lys Arg Arg Gln Arg Ile 
            740                 745                 750         


Lys Ile Glu Ala Asn Trp Asp Leu Phe Tyr Tyr Arg Phe Gly Gln Asp 
        755                 760                 765             


His Ala Arg Ser Asn Leu Ile Trp Asn Phe Lys Thr Arg Glu Glu Leu 
    770                 775                 780                 


Lys Asp Thr Leu Glu Ser Glu Met Arg Ala Phe Asn Ile Asp Arg Glu 
785                 790                 795                 800 


Leu Gly Ser Ala Asn Val Ile Ser Trp Asn His His Glu Phe Glu Val 
                805                 810                 815     


Lys Tyr Glu Cys Leu Ala Glu Glu Ile Lys Ile Gly Asp Tyr Tyr Leu 
            820                 825                 830         


Arg Leu Leu Leu Glu Glu Asp Glu Asn Glu Glu Ser Gly Ser Ile Lys 
        835                 840                 845             


Arg Ser Tyr Glu Phe Phe Asn Glu Leu Tyr His Arg Phe Leu Leu Thr 
    850                 855                 860                 


Pro Lys Val Asn Met Lys Cys Leu Cys Leu Gln Ala Leu Ala Ile Val 
865                 870                 875                 880 


Tyr Gly Arg Cys His Glu Glu Ile Gly Pro Phe Thr Asp Thr Arg Tyr 
                885                 890                 895     


Ile Ile Gly Met Leu Glu Arg Cys Thr Asp Lys Leu Glu Arg Asp Arg 
            900                 905                 910         


Leu Ile Leu Phe Leu Asn Lys Leu Ile Leu Asn Lys Lys Asn Val Lys 
        915                 920                 925             


Asp Leu Met Asp Ser Asn Gly Ile Arg Ile Leu Val Asp Leu Leu Thr 
    930                 935                 940                 


Leu Ala His Leu His Val Ser Arg Ala Thr Val Pro Leu Gln Ser Asn 
945                 950                 955                 960 


Val Ile Glu Ala Ala Pro Asp Met Lys Arg Glu Ser Glu Lys Glu Trp 
                965                 970                 975     


Tyr Phe Gly Asn Ala Asp Lys Glu Arg Ser Gly Pro Tyr Gly Phe His 
            980                 985                 990         


Glu Met Gln Glu Leu Trp Thr Lys  Gly Met Leu Asn Ala  Lys Thr Arg 
        995                 1000                 1005             


Cys Trp  Ala Gln Gly Met Asp  Gly Trp Arg Pro Leu  Gln Ser Ile 
    1010                 1015                 1020             


Pro Gln  Leu Lys Trp Cys Leu  Leu Ala Ser Gly Gln  Ala Val Leu 
    1025                 1030                 1035             


Asn Glu  Thr Asp Leu Ala Thr  Leu Ile Leu Asn Met  Leu Ile Thr 
    1040                 1045                 1050             


Met Cys  Gly Tyr Phe Pro Ser  Arg Asp Gln Asp Asn  Ala Ile Ile 
    1055                 1060                 1065             


Arg Pro  Leu Pro Lys Val Lys  Arg Leu Leu Ser Asp  Ser Thr Cys 
    1070                 1075                 1080             


Leu Pro  His Ile Ile Gln Leu  Leu Leu Thr Phe Asp  Pro Ile Leu 
    1085                 1090                 1095             


Val Glu  Lys Val Ala Ile Leu  Leu Tyr His Ile Met  Gln Asp Asn 
    1100                 1105                 1110             


Pro Gln  Leu Pro Arg Leu Tyr  Leu Ser Gly Val Phe  Phe Phe Ile 
    1115                 1120                 1125             


Met Met  Tyr Thr Gly Ser Asn  Val Leu Pro Val Ala  Arg Phe Leu 
    1130                 1135                 1140             


Lys Tyr  Thr His Thr Lys Gln  Ala Phe Lys Ser Glu  Glu Thr Lys 
    1145                 1150                 1155             


Gly Gln  Asp Ile Phe Gln Arg  Ser Ile Leu Gly His  Ile Leu Pro 
    1160                 1165                 1170             


Glu Ala  Met Val Cys Tyr Leu  Glu Asn Tyr Glu Pro  Glu Lys Phe 
    1175                 1180                 1185             


Ser Glu  Ile Phe Leu Gly Glu  Phe Asp Thr Pro Glu  Ala Ile Trp 
    1190                 1195                 1200             


Ser Ser  Glu Met Arg Arg Leu  Met Ile Glu Lys Ile  Ala Ala His 
    1205                 1210                 1215             


Leu Ala  Asp Phe Thr Pro Arg  Leu Gln Ser Asn Thr  Arg Ala Leu 
    1220                 1225                 1230             


Tyr Gln  Tyr Cys Pro Ile Pro  Ile Ile Asn Tyr Pro  Gln Leu Glu 
    1235                 1240                 1245             


Asn Glu  Leu Phe Cys Asn Ile  Tyr Tyr Leu Lys Gln  Leu Cys Asp 
    1250                 1255                 1260             


Thr Leu  Arg Phe Pro Asp Trp  Pro Ile Lys Asp Pro  Val Lys Leu 
    1265                 1270                 1275             


Leu Lys  Asp Thr Leu Asp Ala  Trp Lys Lys Glu Val  Glu Lys Lys 
    1280                 1285                 1290             


Pro Pro  Met Met Ser Ile Asp  Asp Ala Tyr Glu Val  Leu Asn Leu 
    1295                 1300                 1305             


Pro Gln  Gly Gln Gly Pro His  Asp Glu Ser Lys Ile  Arg Lys Ala 
    1310                 1315                 1320             


Tyr Phe  Arg Leu Ala Gln Lys  Tyr His Pro Asp Lys  Asn Pro Glu 
    1325                 1330                 1335             


Gly Arg  Asp Met Phe Glu Lys  Val Asn Lys Ala Tyr  Glu Phe Leu 
    1340                 1345                 1350             


Cys Thr  Lys Ser Ala Lys Ile  Val Asp Gly Pro Asp  Pro Glu Asn 
    1355                 1360                 1365             


Ile Ile  Leu Ile Leu Lys Thr  Gln Ser Ile Leu Phe  Asn Arg His 
    1370                 1375                 1380             


Lys Glu  Asp Leu Gln Pro Tyr  Lys Tyr Ala Gly Tyr  Pro Met Leu 
    1385                 1390                 1395             


Ile Arg  Thr Ile Thr Met Glu  Thr Ser Asp Asp Leu  Leu Phe Ser 
    1400                 1405                 1410             


Lys Glu  Ser Pro Leu Leu Pro  Ala Ala Thr Glu Leu  Ala Phe His 
    1415                 1420                 1425             


Thr Val  Asn Cys Ser Ala Leu  Asn Ala Glu Glu Leu  Arg Arg Glu 
    1430                 1435                 1440             


Asn Gly  Leu Glu Val Leu Gln  Glu Ala Phe Ser Arg  Cys Val Ala 
    1445                 1450                 1455             


Val Leu  Thr Arg Ala Ser Lys  Pro Ser Asp Met Ser  Val Gln Val 
    1460                 1465                 1470             


Cys Gly  Tyr Ile Ser Lys Cys  Tyr Ser Val Ala Ala  Gln Phe Glu 
    1475                 1480                 1485             


Glu Cys  Arg Glu Lys Ile Thr  Glu Met Pro Ser Ile  Ile Lys Asp 
    1490                 1495                 1500             


Leu Cys  Arg Val Leu Tyr Phe  Gly Lys Ser Ile Pro  Arg Val Ala 
    1505                 1510                 1515             


Ala Leu  Gly Val Glu Cys Val  Ser Ser Phe Ala Val  Asp Phe Trp 
    1520                 1525                 1530             


Leu Gln  Thr His Leu Phe Gln  Ala Gly Ile Leu Trp  Tyr Leu Leu 
    1535                 1540                 1545             


Gly Phe  Leu Phe Asn Tyr Asp  Tyr Thr Leu Glu Glu  Ser Gly Ile 
    1550                 1555                 1560             


Gln Lys  Ser Glu Glu Thr Asn  Gln Gln Glu Val Ala  Asn Ser Leu 
    1565                 1570                 1575             


Ala Lys  Leu Ser Val His Ala  Leu Ser Arg Leu Gly  Gly Tyr Leu 
    1580                 1585                 1590             


Ala Glu  Glu Gln Ala Thr Pro  Glu Asn Pro Thr Ile  Arg Lys Ser 
    1595                 1600                 1605             


Leu Ala  Gly Met Leu Thr Pro  Tyr Val Ala Arg Lys  Leu Ala Val 
    1610                 1615                 1620             


Ala Ser  Val Thr Glu Ile Leu  Lys Met Leu Asn Ser  Asn Thr Glu 
    1625                 1630                 1635             


Ser Pro  Tyr Leu Ile Trp Asn  Asn Ser Thr Arg Ala  Glu Leu Leu 
    1640                 1645                 1650             


Glu Phe  Leu Glu Ser Gln Gln  Glu Asn Met Ile Lys  Lys Gly Asp 
    1655                 1660                 1665             


Cys Asp  Lys Thr Tyr Gly Ser  Glu Phe Val Tyr Ser  Asp His Ala 
    1670                 1675                 1680             


Lys Glu  Leu Ile Val Gly Glu  Ile Phe Val Arg Val  Tyr Asn Glu 
    1685                 1690                 1695             


Val Pro  Thr Phe Gln Leu Glu  Val Pro Lys Ala Phe  Ala Ala Ser 
    1700                 1705                 1710             


Leu Leu  Asp Tyr Ile Gly Ser  Gln Ala Gln Tyr Leu  His Thr Phe 
    1715                 1720                 1725             


Met Ala  Ile Thr His Ala Ala  Lys Val Glu Ser Glu  Gln His Gly 
    1730                 1735                 1740             


Asp Arg  Leu Pro Arg Val Glu  Met Ala Leu Glu Ala  Leu Arg Asn 
    1745                 1750                 1755             


Val Ile  Lys Tyr Asn Pro Gly  Ser Glu Ser Glu Cys  Ile Gly His 
    1760                 1765                 1770             


Phe Lys  Leu Ile Phe Ser Leu  Leu Arg Val His Gly  Ala Gly Gln 
    1775                 1780                 1785             


Val Gln  Gln Leu Ala Leu Glu  Val Val Asn Ile Val  Thr Ser Asn 
    1790                 1795                 1800             


Gln Asp  Cys Val Asn Asn Ile  Ala Glu Ser Met Val  Leu Ser Ser 
    1805                 1810                 1815             


Leu Leu  Ala Leu Leu His Ser  Leu Pro Ser Ser Arg  Gln Leu Val 
    1820                 1825                 1830             


Leu Glu  Thr Leu Tyr Ala Leu  Thr Ser Ser Thr Lys  Ile Ile Lys 
    1835                 1840                 1845             


Glu Ala  Met Ala Lys Gly Ala  Leu Ile Tyr Leu Leu  Asp Met Phe 
    1850                 1855                 1860             


Cys Asn  Ser Thr His Pro Gln  Val Arg Ala Gln Thr  Ala Glu Leu 
    1865                 1870                 1875             


Phe Ala  Lys Met Thr Ala Asp  Lys Leu Ile Gly Pro  Lys Val Arg 
    1880                 1885                 1890             


Ile Thr  Leu Met Lys Phe Leu  Pro Ser Val Phe Met  Asp Ala Met 
    1895                 1900                 1905             


Arg Asp  Asn Pro Glu Ala Ala  Val His Ile Phe Glu  Gly Thr His 
    1910                 1915                 1920             


Glu Asn  Pro Glu Leu Ile Trp  Asn Asp Asn Ser Arg  Asp Lys Val 
    1925                 1930                 1935             


Ser Thr  Thr Val Arg Glu Met  Met Leu Glu His Phe  Lys Asn Gln 
    1940                 1945                 1950             


Gln Asp  Asn Pro Glu Ala Asn  Trp Lys Leu Pro Glu  Asp Phe Ala 
    1955                 1960                 1965             


Val Val  Phe Gly Glu Ala Glu  Gly Glu Leu Ala Val  Gly Gly Val 
    1970                 1975                 1980             


Phe Leu  Arg Ile Phe Ile Ala  Gln Pro Ala Trp Val  Leu Arg Lys 
    1985                 1990                 1995             


Pro Arg  Glu Phe Leu Ile Ala  Leu Leu Glu Lys Leu  Thr Glu Leu 
    2000                 2005                 2010             


Leu Glu  Lys Asn Asn Pro His  Gly Glu Thr Leu Glu  Thr Leu Thr 
    2015                 2020                 2025             


Met Ala  Thr Val Cys Leu Phe  Ser Ala Gln Pro Gln  Leu Ala Asp 
    2030                 2035                 2040             


Gln Val  Pro Pro Leu Gly His  Leu Pro Lys Val Ile  Gln Ala Met 
    2045                 2050                 2055             


Asn His  Arg Asn Asn Ala Ile  Pro Lys Ser Ala Ile  Arg Val Ile 
    2060                 2065                 2070             


His Ala  Leu Ser Glu Asn Glu  Leu Cys Val Arg Ala  Met Ala Ser 
    2075                 2080                 2085             


Leu Glu  Thr Ile Gly Pro Leu  Met Asn Gly Met Lys  Lys Arg Ala 
    2090                 2095                 2100             


Asp Thr  Val Gly Leu Ala Cys  Glu Ala Ile Asn Arg  Met Phe Gln 
    2105                 2110                 2115             


Lys Glu  Gln Ser Glu Leu Val  Ala Gln Ala Leu Lys  Ala Asp Leu 
    2120                 2125                 2130             


Val Pro  Tyr Leu Leu Lys Leu  Leu Glu Gly Ile Gly  Leu Glu Asn 
    2135                 2140                 2145             


Leu Asp  Ser Pro Ala Ala Thr  Lys Ala Gln Ile Val  Lys Ala Leu 
    2150                 2155                 2160             


Lys Ala  Met Thr Arg Ser Leu  Gln Tyr Gly Glu Gln  Val Asn Glu 
    2165                 2170                 2175             


Ile Leu  Cys Arg Ser Ser Val  Trp Ser Ala Phe Lys  Asp Gln Lys 
    2180                 2185                 2190             


His Asp  Leu Phe Ile Ser Glu  Ser Gln Thr Ala Gly  Tyr Leu Thr 
    2195                 2200                 2205             


Gly Pro  Gly Val Ala Gly Tyr  Leu Thr Ala Gly Thr  Ser Thr Ser 
    2210                 2215                 2220             


Val Met  Ser Asn Leu Pro Pro  Pro Val Asp His Glu  Ala Gly Asp 
    2225                 2230                 2235             


Leu Gly  Tyr Gln Thr 
    2240             


<210>  18
<211>  434
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Beta enolase (ENO3)

<400>  18

Met Ala Met Gln Lys Ile Phe Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu His Thr Ala Lys Gly Arg Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gly Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Glu Asn Ile Asn Asn Thr Leu Gly Pro Ala Leu Leu Gln Lys 
65                  70                  75                  80  


Lys Leu Ser Val Val Asp Gln Glu Lys Val Asp Lys Phe Met Ile Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Pro Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ser 
                165                 170                 175     


Ser Phe Lys Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His His Leu 
            180                 185                 190         


Lys Gly Val Ile Lys Ala Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Asn Glu Ala Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gln Ala Ala Gly Tyr Pro Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Asn Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ala Arg His Ile Thr 
            260                 265                 270         


Gly Glu Lys Leu Gly Glu Leu Tyr Lys Ser Phe Ile Lys Asn Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Ala Thr Trp 
    290                 295                 300                 


Thr Ser Phe Leu Ser Gly Val Asn Ile Gln Ile Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Gln Ala Val Glu Lys Lys Ala 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Ile Gln Ala Cys Lys Leu Ala Gln Ser Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met Arg Ile Glu Glu Ala 
                405                 410                 415     


Leu Gly Asp Lys Ala Ile Phe Ala Gly Arg Lys Phe Arg Asn Pro Lys 
            420                 425                 430         


Ala Lys 
        


<210>  19
<211>  210
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Glutathione S-transferase P (GSTP1)

<400>  19

Met Pro Pro Tyr Thr Val Val Tyr Phe Pro Val Arg Gly Arg Cys Ala 
1               5                   10                  15      


Ala Leu Arg Met Leu Leu Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu 
            20                  25                  30          


Val Val Thr Val Glu Thr Trp Gln Glu Gly Ser Leu Lys Ala Ser Cys 
        35                  40                  45              


Leu Tyr Gly Gln Leu Pro Lys Phe Gln Asp Gly Asp Leu Thr Leu Tyr 
    50                  55                  60                  


Gln Ser Asn Thr Ile Leu Arg His Leu Gly Arg Thr Leu Gly Leu Tyr 
65                  70                  75                  80  


Gly Lys Asp Gln Gln Glu Ala Ala Leu Val Asp Met Val Asn Asp Gly 
                85                  90                  95      


Val Glu Asp Leu Arg Cys Lys Tyr Ile Ser Leu Ile Tyr Thr Asn Tyr 
            100                 105                 110         


Glu Ala Gly Lys Asp Asp Tyr Val Lys Ala Leu Pro Gly Gln Leu Lys 
        115                 120                 125             


Pro Phe Glu Thr Leu Leu Ser Gln Asn Gln Gly Gly Lys Thr Phe Ile 
    130                 135                 140                 


Val Gly Asp Gln Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu 
145                 150                 155                 160 


Leu Ile His Glu Val Leu Ala Pro Gly Cys Leu Asp Ala Phe Pro Leu 
                165                 170                 175     


Leu Ser Ala Tyr Val Gly Arg Leu Ser Ala Arg Pro Lys Leu Lys Ala 
            180                 185                 190         


Phe Leu Ala Ser Pro Glu Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly 
        195                 200                 205             


Lys Gln 
    210 


<210>  20
<211>  225
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Glutathione S-transferase Mu 3 (GSTM3)

<400>  20

Met Ser Cys Glu Ser Ser Met Val Leu Gly Tyr Trp Asp Ile Arg Gly 
1               5                   10                  15      


Leu Ala His Ala Ile Arg Leu Leu Leu Glu Phe Thr Asp Thr Ser Tyr 
            20                  25                  30          


Glu Glu Lys Arg Tyr Thr Cys Gly Glu Ala Pro Asp Tyr Asp Arg Ser 
        35                  40                  45              


Gln Trp Leu Asp Val Lys Phe Lys Leu Asp Leu Asp Phe Pro Asn Leu 
    50                  55                  60                  


Pro Tyr Leu Leu Asp Gly Lys Asn Lys Ile Thr Gln Ser Asn Ala Ile 
65                  70                  75                  80  


Leu Arg Tyr Ile Ala Arg Lys His Asn Met Cys Gly Glu Thr Glu Glu 
                85                  90                  95      


Glu Lys Ile Arg Val Asp Ile Ile Glu Asn Gln Val Met Asp Phe Arg 
            100                 105                 110         


Thr Gln Leu Ile Arg Leu Cys Tyr Ser Ser Asp His Glu Lys Leu Lys 
        115                 120                 125             


Pro Gln Tyr Leu Glu Glu Leu Pro Gly Gln Leu Lys Gln Phe Ser Met 
    130                 135                 140                 


Phe Leu Gly Lys Phe Ser Trp Phe Ala Gly Glu Lys Leu Thr Phe Val 
145                 150                 155                 160 


Asp Phe Leu Thr Tyr Asp Ile Leu Asp Gln Asn Arg Ile Phe Asp Pro 
                165                 170                 175     


Lys Cys Leu Asp Glu Phe Pro Asn Leu Lys Ala Phe Met Cys Arg Phe 
            180                 185                 190         


Glu Ala Leu Glu Lys Ile Ala Ala Tyr Leu Gln Ser Asp Gln Phe Cys 
        195                 200                 205             


Lys Met Pro Ile Asn Asn Lys Met Ala Gln Trp Gly Asn Lys Pro Val 
    210                 215                 220                 


Cys 
225 


<210>  21
<211>  419
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Farnesyl pyrophosphate synthase Variant 2

<400>  21

Met Pro Leu Ser Arg Trp Leu Arg Ser Val Gly Val Phe Leu Leu Pro 
1               5                   10                  15      


Ala Pro Tyr Trp Ala Pro Arg Glu Arg Trp Leu Gly Ser Leu Arg Arg 
            20                  25                  30          


Pro Ser Leu Val His Gly Tyr Pro Val Leu Ala Trp His Ser Ala Arg 
        35                  40                  45              


Cys Trp Cys Gln Ala Trp Thr Glu Glu Pro Arg Ala Leu Cys Ser Ser 
    50                  55                  60                  


Leu Arg Met Asn Gly Asp Gln Asn Ser Asp Val Tyr Ala Gln Glu Lys 
65                  70                  75                  80  


Gln Asp Phe Val Gln His Phe Ser Gln Ile Val Arg Val Leu Thr Glu 
                85                  90                  95      


Asp Glu Met Gly His Pro Glu Ile Gly Asp Ala Ile Ala Arg Leu Lys 
            100                 105                 110         


Glu Val Leu Glu Tyr Asn Ala Ile Gly Gly Lys Tyr Asn Arg Gly Leu 
        115                 120                 125             


Thr Val Val Val Ala Phe Arg Glu Leu Val Glu Pro Arg Lys Gln Asp 
    130                 135                 140                 


Ala Asp Ser Leu Gln Arg Ala Trp Thr Val Gly Trp Cys Val Glu Leu 
145                 150                 155                 160 


Leu Gln Ala Phe Phe Leu Val Ala Asp Asp Ile Met Asp Ser Ser Leu 
                165                 170                 175     


Thr Arg Arg Gly Gln Ile Cys Trp Tyr Gln Lys Pro Gly Val Gly Leu 
            180                 185                 190         


Asp Ala Ile Asn Asp Ala Asn Leu Leu Glu Ala Cys Ile Tyr Arg Leu 
        195                 200                 205             


Leu Lys Leu Tyr Cys Arg Glu Gln Pro Tyr Tyr Leu Asn Leu Ile Glu 
    210                 215                 220                 


Leu Phe Leu Gln Ser Ser Tyr Gln Thr Glu Ile Gly Gln Thr Leu Asp 
225                 230                 235                 240 


Leu Leu Thr Ala Pro Gln Gly Asn Val Asp Leu Val Arg Phe Thr Glu 
                245                 250                 255     


Lys Arg Tyr Lys Ser Ile Val Lys Tyr Lys Thr Ala Phe Tyr Ser Phe 
            260                 265                 270         


Tyr Leu Pro Ile Ala Ala Ala Met Tyr Met Ala Gly Ile Asp Gly Glu 
        275                 280                 285             


Lys Glu His Ala Asn Ala Lys Lys Ile Leu Leu Glu Met Gly Glu Phe 
    290                 295                 300                 


Phe Gln Ile Gln Asp Asp Tyr Leu Asp Leu Phe Gly Asp Pro Ser Val 
305                 310                 315                 320 


Thr Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu 
                325                 330                 335     


Val Val Gln Cys Leu Gln Arg Ala Thr Pro Glu Gln Tyr Gln Ile Leu 
            340                 345                 350         


Lys Glu Asn Tyr Gly Gln Lys Glu Ala Glu Lys Val Ala Arg Val Lys 
        355                 360                 365             


Ala Leu Tyr Glu Glu Leu Asp Leu Pro Ala Val Phe Leu Gln Tyr Glu 
    370                 375                 380                 


Glu Asp Ser Tyr Ser His Ile Met Ala Leu Ile Glu Gln Tyr Ala Ala 
385                 390                 395                 400 


Pro Leu Pro Pro Ala Val Phe Leu Gly Leu Ala Arg Lys Ile Tyr Lys 
                405                 410                 415     


Arg Arg Lys 
            


<210>  22
<211>  353
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Farnesyl pyrophosphate synthase Variant 3

<400>  22

Met Asn Gly Asp Gln Asn Ser Asp Val Tyr Ala Gln Glu Lys Gln Asp 
1               5                   10                  15      


Phe Val Gln His Phe Ser Gln Ile Val Arg Val Leu Thr Glu Asp Glu 
            20                  25                  30          


Met Gly His Pro Glu Ile Gly Asp Ala Ile Ala Arg Leu Lys Glu Val 
        35                  40                  45              


Leu Glu Tyr Asn Ala Ile Gly Gly Lys Tyr Asn Arg Gly Leu Thr Val 
    50                  55                  60                  


Val Val Ala Phe Arg Glu Leu Val Glu Pro Arg Lys Gln Asp Ala Asp 
65                  70                  75                  80  


Ser Leu Gln Arg Ala Trp Thr Val Gly Trp Cys Val Glu Leu Leu Gln 
                85                  90                  95      


Ala Phe Phe Leu Val Ala Asp Asp Ile Met Asp Ser Ser Leu Thr Arg 
            100                 105                 110         


Arg Gly Gln Ile Cys Trp Tyr Gln Lys Pro Gly Val Gly Leu Asp Ala 
        115                 120                 125             


Ile Asn Asp Ala Asn Leu Leu Glu Ala Cys Ile Tyr Arg Leu Leu Lys 
    130                 135                 140                 


Leu Tyr Cys Arg Glu Gln Pro Tyr Tyr Leu Asn Leu Ile Glu Leu Phe 
145                 150                 155                 160 


Leu Gln Ser Ser Tyr Gln Thr Glu Ile Gly Gln Thr Leu Asp Leu Leu 
                165                 170                 175     


Thr Ala Pro Gln Gly Asn Val Asp Leu Val Arg Phe Thr Glu Lys Arg 
            180                 185                 190         


Tyr Lys Ser Ile Val Lys Tyr Lys Thr Ala Phe Tyr Ser Phe Tyr Leu 
        195                 200                 205             


Pro Ile Ala Ala Ala Met Tyr Met Ala Gly Ile Asp Gly Glu Lys Glu 
    210                 215                 220                 


His Ala Asn Ala Lys Lys Ile Leu Leu Glu Met Gly Glu Phe Phe Gln 
225                 230                 235                 240 


Ile Gln Asp Asp Tyr Leu Asp Leu Phe Gly Asp Pro Ser Val Thr Gly 
                245                 250                 255     


Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu Val Val 
            260                 265                 270         


Gln Cys Leu Gln Arg Ala Thr Pro Glu Gln Tyr Gln Ile Leu Lys Glu 
        275                 280                 285             


Asn Tyr Gly Gln Lys Glu Ala Glu Lys Val Ala Arg Val Lys Ala Leu 
    290                 295                 300                 


Tyr Glu Glu Leu Asp Leu Pro Ala Val Phe Leu Gln Tyr Glu Glu Asp 
305                 310                 315                 320 


Ser Tyr Ser His Ile Met Ala Leu Ile Glu Gln Tyr Ala Ala Pro Leu 
                325                 330                 335     


Pro Pro Ala Val Phe Leu Gly Leu Ala Arg Lys Ile Tyr Lys Arg Arg 
            340                 345                 350         


Lys 
    


<210>  23
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Asn Gly Asp Gln Asn Ser Asp Val Tyr Ala Gln Glu Lys Gln Asp 
1               5                   10                  15      


Phe Val Gln His Phe Ser Gln Ile Val Arg Val Leu Thr Glu Asp Glu 
            20                  25                  30          


Met Gly His Pro Glu Ile Gly Asp Ala Ile Ala Arg Leu Lys Glu Val 
        35                  40                  45              


Leu Glu Tyr Asn Ala Ile Gly Gly Lys Tyr Asn Arg Gly Leu Thr Val 
    50                  55                  60                  


Val Val Ala Phe Arg Glu Leu Val Glu Pro Arg Lys Gln Asp Ala Asp 
65                  70                  75                  80  


Ser Leu Gln Arg Ala Trp Thr Val Gly Trp Cys Val Glu Leu Leu Gln 
                85                  90                  95      


Ala Phe Phe Leu Val Ala Asp Asp Ile Met Asp Ser Ser Leu Thr Arg 
            100                 105                 110         


Arg Gly Gln Ile Cys Trp Tyr Gln Lys Pro Gly Val Gly Leu Asp Ala 
        115                 120                 125             


Ile Asn Asp Ala Asn Leu Leu Glu Ala Cys Ile Tyr Arg Leu Leu Lys 
    130                 135                 140                 


Leu Tyr Cys Arg Glu Gln Pro Tyr Tyr Leu Asn Leu Ile Glu Leu Phe 
145                 150                 155                 160 


Leu Gln Ser Ser Tyr Gln Thr Glu Ile Gly Gln Thr Leu Asp Leu Leu 
                165                 170                 175     


Thr Ala Pro Gln Gly Asn Val Asp Leu Val Arg Phe Thr Glu Lys Arg 
            180                 185                 190         


Tyr Lys Ser Ile Val Lys Tyr Lys Thr Ala Phe Tyr Ser Phe Tyr Leu 
        195                 200                 205             


Pro Ile Ala Ala Ala Met Tyr Met Ala Gly Ile Asp Gly Glu Lys Glu 
    210                 215                 220                 


His Ala Asn Ala Lys Lys Ile Leu Leu Glu Met Gly Glu Phe Phe Gln 
225                 230                 235                 240 


Ile Gln Asp Asp Tyr Leu Asp Leu Phe Gly Asp Pro Ser Val Thr Gly 
                245                 250                 255     


Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu Val Val 
            260                 265                 270         


Gln Cys Leu Gln Arg Ala Thr Pro Glu Gln Tyr Gln Ile Leu Lys Glu 
        275                 280                 285             


Asn Tyr Gly Gln Lys Glu Ala Glu Lys Val Ala Arg Val Lys Ala Leu 
    290                 295                 300                 


Tyr Glu Glu Leu Asp Leu Pro Ala Val Phe Leu Gln Tyr Glu Glu Asp 
305                 310                 315                 320 


Ser Tyr Ser His Ile Met Ala Leu Ile Glu Gln Tyr Ala Ala Pro Leu 
                325                 330                 335     


Pro Pro Ala Val Phe Leu Gly Leu Ala Arg Lys Ile Tyr Lys Arg Arg 
            340                 345                 350         


Lys 
    


<210>  24
<211>  248
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Farnesyl pyrophosphate synthase Variant 5

<400>  24

Met Asp Ser Ser Leu Thr Arg Arg Gly Gln Ile Cys Trp Tyr Gln Lys 
1               5                   10                  15      


Pro Gly Val Gly Leu Asp Ala Ile Asn Asp Ala Asn Leu Leu Glu Ala 
            20                  25                  30          


Cys Ile Tyr Arg Leu Leu Lys Leu Tyr Cys Arg Glu Gln Pro Tyr Tyr 
        35                  40                  45              


Leu Asn Leu Ile Glu Leu Phe Leu Gln Ser Ser Tyr Gln Thr Glu Ile 
    50                  55                  60                  


Gly Gln Thr Leu Asp Leu Leu Thr Ala Pro Gln Gly Asn Val Asp Leu 
65                  70                  75                  80  


Val Arg Phe Thr Glu Lys Arg Tyr Lys Ser Ile Val Lys Tyr Lys Thr 
                85                  90                  95      


Ala Phe Tyr Ser Phe Tyr Leu Pro Ile Ala Ala Ala Met Tyr Met Ala 
            100                 105                 110         


Gly Ile Asp Gly Glu Lys Glu His Ala Asn Ala Lys Lys Ile Leu Leu 
        115                 120                 125             


Glu Met Gly Glu Phe Phe Gln Ile Gln Asp Asp Tyr Leu Asp Leu Phe 
    130                 135                 140                 


Gly Asp Pro Ser Val Thr Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn 
145                 150                 155                 160 


Lys Cys Ser Trp Leu Val Val Gln Cys Leu Gln Arg Ala Thr Pro Glu 
                165                 170                 175     


Gln Tyr Gln Ile Leu Lys Glu Asn Tyr Gly Gln Lys Glu Ala Glu Lys 
            180                 185                 190         


Val Ala Arg Val Lys Ala Leu Tyr Glu Glu Leu Asp Leu Pro Ala Val 
        195                 200                 205             


Phe Leu Gln Tyr Glu Glu Asp Ser Tyr Ser His Ile Met Ala Leu Ile 
    210                 215                 220                 


Glu Gln Tyr Ala Ala Pro Leu Pro Pro Ala Val Phe Leu Gly Leu Ala 
225                 230                 235                 240 


Arg Lys Ile Tyr Lys Arg Arg Lys 
                245             


<210>  25
<211>  353
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Farnesyl pyrophosphate synthase Variant 6

<400>  25

Met Asn Gly Asp Gln Asn Ser Asp Val Tyr Ala Gln Glu Lys Gln Asp 
1               5                   10                  15      


Phe Val Gln His Phe Ser Gln Ile Val Arg Val Leu Thr Glu Asp Glu 
            20                  25                  30          


Met Gly His Pro Glu Ile Gly Asp Ala Ile Ala Arg Leu Lys Glu Val 
        35                  40                  45              


Leu Glu Tyr Asn Ala Ile Gly Gly Lys Tyr Asn Arg Gly Leu Thr Val 
    50                  55                  60                  


Val Val Ala Phe Arg Glu Leu Val Glu Pro Arg Lys Gln Asp Ala Asp 
65                  70                  75                  80  


Ser Leu Gln Arg Ala Trp Thr Val Gly Trp Cys Val Glu Leu Leu Gln 
                85                  90                  95      


Ala Phe Phe Leu Val Ala Asp Asp Ile Met Asp Ser Ser Leu Thr Arg 
            100                 105                 110         


Arg Gly Gln Ile Cys Trp Tyr Gln Lys Pro Gly Val Gly Leu Asp Ala 
        115                 120                 125             


Ile Asn Asp Ala Asn Leu Leu Glu Ala Cys Ile Tyr Arg Leu Leu Lys 
    130                 135                 140                 


Leu Tyr Cys Arg Glu Gln Pro Tyr Tyr Leu Asn Leu Ile Glu Leu Phe 
145                 150                 155                 160 


Leu Gln Ser Ser Tyr Gln Thr Glu Ile Gly Gln Thr Leu Asp Leu Leu 
                165                 170                 175     


Thr Ala Pro Gln Gly Asn Val Asp Leu Val Arg Phe Thr Glu Lys Arg 
            180                 185                 190         


Tyr Lys Ser Ile Val Lys Tyr Lys Thr Ala Phe Tyr Ser Phe Tyr Leu 
        195                 200                 205             


Pro Ile Ala Ala Ala Met Tyr Met Ala Gly Ile Asp Gly Glu Lys Glu 
    210                 215                 220                 


His Ala Asn Ala Lys Lys Ile Leu Leu Glu Met Gly Glu Phe Phe Gln 
225                 230                 235                 240 


Ile Gln Asp Asp Tyr Leu Asp Leu Phe Gly Asp Pro Ser Val Thr Gly 
                245                 250                 255     


Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu Val Val 
            260                 265                 270         


Gln Cys Leu Gln Arg Ala Thr Pro Glu Gln Tyr Gln Ile Leu Lys Glu 
        275                 280                 285             


Asn Tyr Gly Gln Lys Glu Ala Glu Lys Val Ala Arg Val Lys Ala Leu 
    290                 295                 300                 


Tyr Glu Glu Leu Asp Leu Pro Ala Val Phe Leu Gln Tyr Glu Glu Asp 
305                 310                 315                 320 


Ser Tyr Ser His Ile Met Ala Leu Ile Glu Gln Tyr Ala Ala Pro Leu 
                325                 330                 335     


Pro Pro Ala Val Phe Leu Gly Leu Ala Arg Lys Ile Tyr Lys Arg Arg 
            340                 345                 350         


Lys 
    


<210>  26
<211>  274
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Farnesyl pyrophosphate synthase Variant 7

<400>  26

Met Pro Leu Ser Arg Trp Leu Arg Ser Val Gly Val Phe Leu Leu Pro 
1               5                   10                  15      


Ala Pro Tyr Trp Ala Pro Arg Glu Arg Trp Leu Gly Ser Leu Arg Arg 
            20                  25                  30          


Pro Ser Leu Val His Gly Tyr Pro Val Leu Ala Trp His Ser Ala Arg 
        35                  40                  45              


Cys Trp Cys Gln Ala Trp Thr Glu Glu Pro Arg Ala Leu Cys Ser Ser 
    50                  55                  60                  


Leu Arg Met Asn Gly Asp Gln Asn Ser Asp Val Tyr Ala Gln Glu Lys 
65                  70                  75                  80  


Gln Asp Phe Val Gln His Phe Ser Gln Ile Val Arg Val Leu Thr Glu 
                85                  90                  95      


Asp Glu Met Gly His Pro Glu Ile Gly Asp Ala Ile Ala Arg Leu Lys 
            100                 105                 110         


Glu Val Leu Glu Tyr Asn Ala Ile Gly Gly Lys Tyr Asn Arg Gly Leu 
        115                 120                 125             


Thr Val Val Val Ala Phe Arg Glu Leu Val Glu Pro Arg Lys Gln Asp 
    130                 135                 140                 


Ala Asp Ser Leu Gln Arg Ala Trp Thr Val Gly Trp Cys Val Glu Leu 
145                 150                 155                 160 


Leu Gln Ala Phe Phe Leu Val Ala Asp Asp Ile Met Asp Ser Ser Leu 
                165                 170                 175     


Thr Arg Arg Gly Gln Ile Cys Trp Tyr Gln Lys Pro Gly Val Gly Leu 
            180                 185                 190         


Asp Ala Ile Asn Asp Ala Asn Leu Leu Glu Ala Cys Ile Tyr Arg Leu 
        195                 200                 205             


Leu Lys Leu Tyr Cys Arg Glu Gln Pro Tyr Tyr Leu Asn Leu Ile Glu 
    210                 215                 220                 


Leu Phe Leu Gln Ser Ser Tyr Gln Thr Glu Ile Gly Gln Thr Leu Asp 
225                 230                 235                 240 


Leu Leu Thr Ala Pro Gln Gly Asn Val Asp Leu Val Arg Phe Thr Glu 
                245                 250                 255     


Lys Arg Tyr Lys Ser Ile Val Lys Tyr Lys Thr Ala Phe Tyr Ser Phe 
            260                 265                 270         


Tyr Leu 
        


<210>  27
<211>  174
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Farnesyl pyrophosphate synthase Variant 8

<400>  27

Met Pro Leu Ser Arg Trp Leu Arg Ser Val Gly Val Phe Leu Leu Pro 
1               5                   10                  15      


Ala Pro Tyr Trp Ala Pro Arg Glu Arg Trp Leu Gly Ser Leu Arg Arg 
            20                  25                  30          


Pro Ser Leu Val His Gly Tyr Pro Val Leu Ala Trp His Ser Ala Arg 
        35                  40                  45              


Cys Trp Cys Gln Ala Trp Thr Glu Glu Pro Arg Ala Leu Cys Ser Ser 
    50                  55                  60                  


Leu Arg Met Asn Gly Asp Gln Asn Ser Asp Val Tyr Ala Gln Glu Lys 
65                  70                  75                  80  


Gln Asp Phe Val Gln His Phe Ser Gln Ile Val Arg Val Leu Thr Glu 
                85                  90                  95      


Asp Glu Met Gly His Pro Glu Ile Gly Asp Ala Ile Ala Arg Leu Lys 
            100                 105                 110         


Glu Val Leu Glu Tyr Asn Ala Ile Gly Gly Lys Tyr Asn Arg Gly Leu 
        115                 120                 125             


Thr Val Val Val Ala Phe Arg Glu Leu Val Glu Pro Arg Lys Gln Asp 
    130                 135                 140                 


Ala Asp Ser Leu Gln Arg Ala Trp Thr Val Gly Trp Cys Val Glu Leu 
145                 150                 155                 160 


Leu Gln Ala Phe Phe Leu Val Ala Asp Asp Ile Met Asp Ser 
                165                 170                 


<210>  28
<211>  2818
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Neurofibromin 1 Variant 2

<400>  28

Met Ala Ala His Arg Pro Val Glu Trp Val Gln Ala Val Val Ser Arg 
1               5                   10                  15      


Phe Asp Glu Gln Leu Pro Ile Lys Thr Gly Gln Gln Asn Thr His Thr 
            20                  25                  30          


Lys Val Ser Thr Glu His Asn Lys Glu Cys Leu Ile Asn Ile Ser Lys 
        35                  40                  45              


Tyr Lys Phe Ser Leu Val Ile Ser Gly Leu Thr Thr Ile Leu Lys Asn 
    50                  55                  60                  


Val Asn Asn Met Arg Ile Phe Gly Glu Ala Ala Glu Lys Asn Leu Tyr 
65                  70                  75                  80  


Leu Ser Gln Leu Ile Ile Leu Asp Thr Leu Glu Lys Cys Leu Ala Gly 
                85                  90                  95      


Gln Pro Lys Asp Thr Met Arg Leu Asp Glu Thr Met Leu Val Lys Gln 
            100                 105                 110         


Leu Leu Pro Glu Ile Cys His Phe Leu His Thr Cys Arg Glu Gly Asn 
        115                 120                 125             


Gln His Ala Ala Glu Leu Arg Asn Ser Ala Ser Gly Val Leu Phe Ser 
    130                 135                 140                 


Leu Ser Cys Asn Asn Phe Asn Ala Val Phe Ser Arg Ile Ser Thr Arg 
145                 150                 155                 160 


Leu Gln Glu Leu Thr Val Cys Ser Glu Asp Asn Val Asp Val His Asp 
                165                 170                 175     


Ile Glu Leu Leu Gln Tyr Ile Asn Val Asp Cys Ala Lys Leu Lys Arg 
            180                 185                 190         


Leu Leu Lys Glu Thr Ala Phe Lys Phe Lys Ala Leu Lys Lys Val Ala 
        195                 200                 205             


Gln Leu Ala Val Ile Asn Ser Leu Glu Lys Ala Phe Trp Asn Trp Val 
    210                 215                 220                 


Glu Asn Tyr Pro Asp Glu Phe Thr Lys Leu Tyr Gln Ile Pro Gln Thr 
225                 230                 235                 240 


Asp Met Ala Glu Cys Ala Glu Lys Leu Phe Asp Leu Val Asp Gly Phe 
                245                 250                 255     


Ala Glu Ser Thr Lys Arg Lys Ala Ala Val Trp Pro Leu Gln Ile Ile 
            260                 265                 270         


Leu Leu Ile Leu Cys Pro Glu Ile Ile Gln Asp Ile Ser Lys Asp Val 
        275                 280                 285             


Val Asp Glu Asn Asn Met Asn Lys Lys Leu Phe Leu Asp Ser Leu Arg 
    290                 295                 300                 


Lys Ala Leu Ala Gly His Gly Gly Ser Arg Gln Leu Thr Glu Ser Ala 
305                 310                 315                 320 


Ala Ile Ala Cys Val Lys Leu Cys Lys Ala Ser Thr Tyr Ile Asn Trp 
                325                 330                 335     


Glu Asp Asn Ser Val Ile Phe Leu Leu Val Gln Ser Met Val Val Asp 
            340                 345                 350         


Leu Lys Asn Leu Leu Phe Asn Pro Ser Lys Pro Phe Ser Arg Gly Ser 
        355                 360                 365             


Gln Pro Ala Asp Val Asp Leu Met Ile Asp Cys Leu Val Ser Cys Phe 
    370                 375                 380                 


Arg Ile Ser Pro His Asn Asn Gln His Phe Lys Ile Cys Leu Ala Gln 
385                 390                 395                 400 


Asn Ser Pro Ser Thr Phe His Tyr Val Leu Val Asn Ser Leu His Arg 
                405                 410                 415     


Ile Ile Thr Asn Ser Ala Leu Asp Trp Trp Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Tyr Cys His Ser Val Glu Leu Arg Asn Met Phe Gly Glu Thr Leu His 
        435                 440                 445             


Lys Ala Val Gln Gly Cys Gly Ala His Pro Ala Ile Arg Met Ala Pro 
    450                 455                 460                 


Ser Leu Thr Phe Lys Glu Lys Val Thr Ser Leu Lys Phe Lys Glu Lys 
465                 470                 475                 480 


Pro Thr Asp Leu Glu Thr Arg Ser Tyr Lys Tyr Leu Leu Leu Ser Met 
                485                 490                 495     


Val Lys Leu Ile His Ala Asp Pro Lys Leu Leu Leu Cys Asn Pro Arg 
            500                 505                 510         


Lys Gln Gly Pro Glu Thr Gln Gly Ser Thr Ala Glu Leu Ile Thr Gly 
        515                 520                 525             


Leu Val Gln Leu Val Pro Gln Ser His Met Pro Glu Ile Ala Gln Glu 
    530                 535                 540                 


Ala Met Glu Ala Leu Leu Val Leu His Gln Leu Asp Ser Ile Asp Leu 
545                 550                 555                 560 


Trp Asn Pro Asp Ala Pro Val Glu Thr Phe Trp Glu Ile Ser Ser Gln 
                565                 570                 575     


Met Leu Phe Tyr Ile Cys Lys Lys Leu Thr Ser His Gln Met Leu Ser 
            580                 585                 590         


Ser Thr Glu Ile Leu Lys Trp Leu Arg Glu Ile Leu Ile Cys Arg Asn 
        595                 600                 605             


Lys Phe Leu Leu Lys Asn Lys Gln Ala Asp Arg Ser Ser Cys His Phe 
    610                 615                 620                 


Leu Leu Phe Tyr Gly Val Gly Cys Asp Ile Pro Ser Ser Gly Asn Thr 
625                 630                 635                 640 


Ser Gln Met Ser Met Asp His Glu Glu Leu Leu Arg Thr Pro Gly Ala 
                645                 650                 655     


Ser Leu Arg Lys Gly Lys Gly Asn Ser Ser Met Asp Ser Ala Ala Gly 
            660                 665                 670         


Cys Ser Gly Thr Pro Pro Ile Cys Arg Gln Ala Gln Thr Lys Leu Glu 
        675                 680                 685             


Val Ala Leu Tyr Met Phe Leu Trp Asn Pro Asp Thr Glu Ala Val Leu 
    690                 695                 700                 


Val Ala Met Ser Cys Phe Arg His Leu Cys Glu Glu Ala Asp Ile Arg 
705                 710                 715                 720 


Cys Gly Val Asp Glu Val Ser Val His Asn Leu Leu Pro Asn Tyr Asn 
                725                 730                 735     


Thr Phe Met Glu Phe Ala Ser Val Ser Asn Met Met Ser Thr Gly Arg 
            740                 745                 750         


Ala Ala Leu Gln Lys Arg Val Met Ala Leu Leu Arg Arg Ile Glu His 
        755                 760                 765             


Pro Thr Ala Gly Asn Thr Glu Ala Trp Glu Asp Thr His Ala Lys Trp 
    770                 775                 780                 


Glu Gln Ala Thr Lys Leu Ile Leu Asn Tyr Pro Lys Ala Lys Met Glu 
785                 790                 795                 800 


Asp Gly Gln Ala Ala Glu Ser Leu His Lys Thr Ile Val Lys Arg Arg 
                805                 810                 815     


Met Ser His Val Ser Gly Gly Gly Ser Ile Asp Leu Ser Asp Thr Asp 
            820                 825                 830         


Ser Leu Gln Glu Trp Ile Asn Met Thr Gly Phe Leu Cys Ala Leu Gly 
        835                 840                 845             


Gly Val Cys Leu Gln Gln Arg Ser Asn Ser Gly Leu Ala Thr Tyr Ser 
    850                 855                 860                 


Pro Pro Met Gly Pro Val Ser Glu Arg Lys Gly Ser Met Ile Ser Val 
865                 870                 875                 880 


Met Ser Ser Glu Gly Asn Ala Asp Thr Pro Val Ser Lys Phe Met Asp 
                885                 890                 895     


Arg Leu Leu Ser Leu Met Val Cys Asn His Glu Lys Val Gly Leu Gln 
            900                 905                 910         


Ile Arg Thr Asn Val Lys Asp Leu Val Gly Leu Glu Leu Ser Pro Ala 
        915                 920                 925             


Leu Tyr Pro Met Leu Phe Asn Lys Leu Lys Asn Thr Ile Ser Lys Phe 
    930                 935                 940                 


Phe Asp Ser Gln Gly Gln Val Leu Leu Thr Asp Thr Asn Thr Gln Phe 
945                 950                 955                 960 


Val Glu Gln Thr Ile Ala Ile Met Lys Asn Leu Leu Asp Asn His Thr 
                965                 970                 975     


Glu Gly Ser Ser Glu His Leu Gly Gln Ala Ser Ile Glu Thr Met Met 
            980                 985                 990         


Leu Asn Leu Val Arg Tyr Val Arg  Val Leu Gly Asn Met  Val His Ala 
        995                 1000                 1005             


Ile Gln  Ile Lys Thr Lys Leu  Cys Gln Leu Val Glu  Val Met Met 
    1010                 1015                 1020             


Ala Arg  Arg Asp Asp Leu Ser  Phe Cys Gln Glu Met  Lys Phe Arg 
    1025                 1030                 1035             


Asn Lys  Met Val Glu Tyr Leu  Thr Asp Trp Val Met  Gly Thr Ser 
    1040                 1045                 1050             


Asn Gln  Ala Ala Asp Asp Asp  Val Lys Cys Leu Thr  Arg Asp Leu 
    1055                 1060                 1065             


Asp Gln  Ala Ser Met Glu Ala  Val Val Ser Leu Leu  Ala Gly Leu 
    1070                 1075                 1080             


Pro Leu  Gln Pro Glu Glu Gly  Asp Gly Val Glu Leu  Met Glu Ala 
    1085                 1090                 1095             


Lys Ser  Gln Leu Phe Leu Lys  Tyr Phe Thr Leu Phe  Met Asn Leu 
    1100                 1105                 1110             


Leu Asn  Asp Cys Ser Glu Val  Glu Asp Glu Ser Ala  Gln Thr Gly 
    1115                 1120                 1125             


Gly Arg  Lys Arg Gly Met Ser  Arg Arg Leu Ala Ser  Leu Arg His 
    1130                 1135                 1140             


Cys Thr  Val Leu Ala Met Ser  Asn Leu Leu Asn Ala  Asn Val Asp 
    1145                 1150                 1155             


Ser Gly  Leu Met His Ser Ile  Gly Leu Gly Tyr His  Lys Asp Leu 
    1160                 1165                 1170             


Gln Thr  Arg Ala Thr Phe Met  Glu Val Leu Thr Lys  Ile Leu Gln 
    1175                 1180                 1185             


Gln Gly  Thr Glu Phe Asp Thr  Leu Ala Glu Thr Val  Leu Ala Asp 
    1190                 1195                 1200             


Arg Phe  Glu Arg Leu Val Glu  Leu Val Thr Met Met  Gly Asp Gln 
    1205                 1210                 1215             


Gly Glu  Leu Pro Ile Ala Met  Ala Leu Ala Asn Val  Val Pro Cys 
    1220                 1225                 1230             


Ser Gln  Trp Asp Glu Leu Ala  Arg Val Leu Val Thr  Leu Phe Asp 
    1235                 1240                 1245             


Ser Arg  His Leu Leu Tyr Gln  Leu Leu Trp Asn Met  Phe Ser Lys 
    1250                 1255                 1260             


Glu Val  Glu Leu Ala Asp Ser  Met Gln Thr Leu Phe  Arg Gly Asn 
    1265                 1270                 1275             


Ser Leu  Ala Ser Lys Ile Met  Thr Phe Cys Phe Lys  Val Tyr Gly 
    1280                 1285                 1290             


Ala Thr  Tyr Leu Gln Lys Leu  Leu Asp Pro Leu Leu  Arg Ile Val 
    1295                 1300                 1305             


Ile Thr  Ser Ser Asp Trp Gln  His Val Ser Phe Glu  Val Asp Pro 
    1310                 1315                 1320             


Thr Arg  Leu Glu Pro Ser Glu  Ser Leu Glu Glu Asn  Gln Arg Asn 
    1325                 1330                 1335             


Leu Leu  Gln Met Thr Glu Lys  Phe Phe His Ala Ile  Ile Ser Ser 
    1340                 1345                 1350             


Ser Ser  Glu Phe Pro Pro Gln  Leu Arg Ser Val Cys  His Cys Leu 
    1355                 1360                 1365             


Tyr Gln  Val Val Ser Gln Arg  Phe Pro Gln Asn Ser  Ile Gly Ala 
    1370                 1375                 1380             


Val Gly  Ser Ala Met Phe Leu  Arg Phe Ile Asn Pro  Ala Ile Val 
    1385                 1390                 1395             


Ser Pro  Tyr Glu Ala Gly Ile  Leu Asp Lys Lys Pro  Pro Pro Arg 
    1400                 1405                 1410             


Ile Glu  Arg Gly Leu Lys Leu  Met Ser Lys Ile Leu  Gln Ser Ile 
    1415                 1420                 1425             


Ala Asn  His Val Leu Phe Thr  Lys Glu Glu His Met  Arg Pro Phe 
    1430                 1435                 1440             


Asn Asp  Phe Val Lys Ser Asn  Phe Asp Ala Ala Arg  Arg Phe Phe 
    1445                 1450                 1455             


Leu Asp  Ile Ala Ser Asp Cys  Pro Thr Ser Asp Ala  Val Asn His 
    1460                 1465                 1470             


Ser Leu  Ser Phe Ile Ser Asp  Gly Asn Val Leu Ala  Leu His Arg 
    1475                 1480                 1485             


Leu Leu  Trp Asn Asn Gln Glu  Lys Ile Gly Gln Tyr  Leu Ser Ser 
    1490                 1495                 1500             


Asn Arg  Asp His Lys Ala Val  Gly Arg Arg Pro Phe  Asp Lys Met 
    1505                 1510                 1515             


Ala Thr  Leu Leu Ala Tyr Leu  Gly Pro Pro Glu His  Lys Pro Val 
    1520                 1525                 1530             


Ala Asp  Thr His Trp Ser Ser  Leu Asn Leu Thr Ser  Ser Lys Phe 
    1535                 1540                 1545             


Glu Glu  Phe Met Thr Arg His  Gln Val His Glu Lys  Glu Glu Phe 
    1550                 1555                 1560             


Lys Ala  Leu Lys Thr Leu Ser  Ile Phe Tyr Gln Ala  Gly Thr Ser 
    1565                 1570                 1575             


Lys Ala  Gly Asn Pro Ile Phe  Tyr Tyr Val Ala Arg  Arg Phe Lys 
    1580                 1585                 1590             


Thr Gly  Gln Ile Asn Gly Asp  Leu Leu Ile Tyr His  Val Leu Leu 
    1595                 1600                 1605             


Thr Leu  Lys Pro Tyr Tyr Ala  Lys Pro Tyr Glu Ile  Val Val Asp 
    1610                 1615                 1620             


Leu Thr  His Thr Gly Pro Ser  Asn Arg Phe Lys Thr  Asp Phe Leu 
    1625                 1630                 1635             


Ser Lys  Trp Phe Val Val Phe  Pro Gly Phe Ala Tyr  Asp Asn Val 
    1640                 1645                 1650             


Ser Ala  Val Tyr Ile Tyr Asn  Cys Asn Ser Trp Val  Arg Glu Tyr 
    1655                 1660                 1665             


Thr Lys  Tyr His Glu Arg Leu  Leu Thr Gly Leu Lys  Gly Ser Lys 
    1670                 1675                 1680             


Arg Leu  Val Phe Ile Asp Cys  Pro Gly Lys Leu Ala  Glu His Ile 
    1685                 1690                 1695             


Glu His  Glu Gln Gln Lys Leu  Pro Ala Ala Thr Leu  Ala Leu Glu 
    1700                 1705                 1710             


Glu Asp  Leu Lys Val Phe His  Asn Ala Leu Lys Leu  Ala His Lys 
    1715                 1720                 1725             


Asp Thr  Lys Val Ser Ile Lys  Val Gly Ser Thr Ala  Val Gln Val 
    1730                 1735                 1740             


Thr Ser  Ala Glu Arg Thr Lys  Val Leu Gly Gln Ser  Val Phe Leu 
    1745                 1750                 1755             


Asn Asp  Ile Tyr Tyr Ala Ser  Glu Ile Glu Glu Ile  Cys Leu Val 
    1760                 1765                 1770             


Asp Glu  Asn Gln Phe Thr Leu  Thr Ile Ala Asn Gln  Gly Thr Pro 
    1775                 1780                 1785             


Leu Thr  Phe Met His Gln Glu  Cys Glu Ala Ile Val  Gln Ser Ile 
    1790                 1795                 1800             


Ile His  Ile Arg Thr Arg Trp  Glu Leu Ser Gln Pro  Asp Ser Ile 
    1805                 1810                 1815             


Pro Gln  His Thr Lys Ile Arg  Pro Lys Asp Val Pro  Gly Thr Leu 
    1820                 1825                 1830             


Leu Asn  Ile Ala Leu Leu Asn  Leu Gly Ser Ser Asp  Pro Ser Leu 
    1835                 1840                 1845             


Arg Ser  Ala Ala Tyr Asn Leu  Leu Cys Ala Leu Thr  Cys Thr Phe 
    1850                 1855                 1860             


Asn Leu  Lys Ile Glu Gly Gln  Leu Leu Glu Thr Ser  Gly Leu Cys 
    1865                 1870                 1875             


Ile Pro  Ala Asn Asn Thr Leu  Phe Ile Val Ser Ile  Ser Lys Thr 
    1880                 1885                 1890             


Leu Ala  Ala Asn Glu Pro His  Leu Thr Leu Glu Phe  Leu Glu Glu 
    1895                 1900                 1905             


Cys Ile  Ser Gly Phe Ser Lys  Ser Ser Ile Glu Leu  Lys His Leu 
    1910                 1915                 1920             


Cys Leu  Glu Tyr Met Thr Pro  Trp Leu Ser Asn Leu  Val Arg Phe 
    1925                 1930                 1935             


Cys Lys  His Asn Asp Asp Ala  Lys Arg Gln Arg Val  Thr Ala Ile 
    1940                 1945                 1950             


Leu Asp  Lys Leu Ile Thr Met  Thr Ile Asn Glu Lys  Gln Met Tyr 
    1955                 1960                 1965             


Pro Ser  Ile Gln Ala Lys Ile  Trp Gly Ser Leu Gly  Gln Ile Thr 
    1970                 1975                 1980             


Asp Leu  Leu Asp Val Val Leu  Asp Ser Phe Ile Lys  Thr Ser Ala 
    1985                 1990                 1995             


Thr Gly  Gly Leu Gly Ser Ile  Lys Ala Glu Val Met  Ala Asp Thr 
    2000                 2005                 2010             


Ala Val  Ala Leu Ala Ser Gly  Asn Val Lys Leu Val  Ser Ser Lys 
    2015                 2020                 2025             


Val Ile  Gly Arg Met Cys Lys  Ile Ile Asp Lys Thr  Cys Leu Ser 
    2030                 2035                 2040             


Pro Thr  Pro Thr Leu Glu Gln  His Leu Met Trp Asp  Asp Ile Ala 
    2045                 2050                 2055             


Ile Leu  Ala Arg Tyr Met Leu  Met Leu Ser Phe Asn  Asn Ser Leu 
    2060                 2065                 2070             


Asp Val  Ala Ala His Leu Pro  Tyr Leu Phe His Val  Val Thr Phe 
    2075                 2080                 2085             


Leu Val  Ala Thr Gly Pro Leu  Ser Leu Arg Ala Ser  Thr His Gly 
    2090                 2095                 2100             


Leu Val  Ile Asn Ile Ile His  Ser Leu Cys Thr Cys  Ser Gln Leu 
    2105                 2110                 2115             


His Phe  Ser Glu Glu Thr Lys  Gln Val Leu Arg Leu  Ser Leu Thr 
    2120                 2125                 2130             


Glu Phe  Ser Leu Pro Lys Phe  Tyr Leu Leu Phe Gly  Ile Ser Lys 
    2135                 2140                 2145             


Val Lys  Ser Ala Ala Val Ile  Ala Phe Arg Ser Ser  Tyr Arg Asp 
    2150                 2155                 2160             


Arg Ser  Phe Ser Pro Gly Ser  Tyr Glu Arg Glu Thr  Phe Ala Leu 
    2165                 2170                 2175             


Thr Ser  Leu Glu Thr Val Thr  Glu Ala Leu Leu Glu  Ile Met Glu 
    2180                 2185                 2190             


Ala Cys  Met Arg Asp Ile Pro  Thr Cys Lys Trp Leu  Asp Gln Trp 
    2195                 2200                 2205             


Thr Glu  Leu Ala Gln Arg Phe  Ala Phe Gln Tyr Asn  Pro Ser Leu 
    2210                 2215                 2220             


Gln Pro  Arg Ala Leu Val Val  Phe Gly Cys Ile Ser  Lys Arg Val 
    2225                 2230                 2235             


Ser His  Gly Gln Ile Lys Gln  Ile Ile Arg Ile Leu  Ser Lys Ala 
    2240                 2245                 2250             


Leu Glu  Ser Cys Leu Lys Gly  Pro Asp Thr Tyr Asn  Ser Gln Val 
    2255                 2260                 2265             


Leu Ile  Glu Ala Thr Val Ile  Ala Leu Thr Lys Leu  Gln Pro Leu 
    2270                 2275                 2280             


Leu Asn  Lys Asp Ser Pro Leu  His Lys Ala Leu Phe  Trp Val Ala 
    2285                 2290                 2295             


Val Ala  Val Leu Gln Leu Asp  Glu Val Asn Leu Tyr  Ser Ala Gly 
    2300                 2305                 2310             


Thr Ala  Leu Leu Glu Gln Asn  Leu His Thr Leu Asp  Ser Leu Arg 
    2315                 2320                 2325             


Ile Phe  Asn Asp Lys Ser Pro  Glu Glu Val Phe Met  Ala Ile Arg 
    2330                 2335                 2340             


Asn Pro  Leu Glu Trp His Cys  Lys Gln Met Asp His  Phe Val Gly 
    2345                 2350                 2355             


Leu Asn  Phe Asn Ser Asn Phe  Asn Phe Ala Leu Val  Gly His Leu 
    2360                 2365                 2370             


Leu Lys  Gly Tyr Arg His Pro  Ser Pro Ala Ile Val  Ala Arg Thr 
    2375                 2380                 2385             


Val Arg  Ile Leu His Thr Leu  Leu Thr Leu Val Asn  Lys His Arg 
    2390                 2395                 2400             


Asn Cys  Asp Lys Phe Glu Val  Asn Thr Gln Ser Val  Ala Tyr Leu 
    2405                 2410                 2415             


Ala Ala  Leu Leu Thr Val Ser  Glu Glu Val Arg Ser  Arg Cys Ser 
    2420                 2425                 2430             


Leu Lys  His Arg Lys Ser Leu  Leu Leu Thr Asp Ile  Ser Met Glu 
    2435                 2440                 2445             


Asn Val  Pro Met Asp Thr Tyr  Pro Ile His His Gly  Asp Pro Ser 
    2450                 2455                 2460             


Tyr Arg  Thr Leu Lys Glu Thr  Gln Pro Trp Ser Ser  Pro Lys Gly 
    2465                 2470                 2475             


Ser Glu  Gly Tyr Leu Ala Ala  Thr Tyr Pro Thr Val  Gly Gln Thr 
    2480                 2485                 2490             


Ser Pro  Arg Ala Arg Lys Ser  Met Ser Leu Asp Met  Gly Gln Pro 
    2495                 2500                 2505             


Ser Gln  Ala Asn Thr Lys Lys  Leu Leu Gly Thr Arg  Lys Ser Phe 
    2510                 2515                 2520             


Asp His  Leu Ile Ser Asp Thr  Lys Ala Pro Lys Arg  Gln Glu Met 
    2525                 2530                 2535             


Glu Ser  Gly Ile Thr Thr Pro  Pro Lys Met Arg Arg  Val Ala Glu 
    2540                 2545                 2550             


Thr Asp  Tyr Glu Met Glu Thr  Gln Arg Ile Ser Ser  Ser Gln Gln 
    2555                 2560                 2565             


His Pro  His Leu Arg Lys Val  Ser Val Ser Glu Ser  Asn Val Leu 
    2570                 2575                 2580             


Leu Asp  Glu Glu Val Leu Thr  Asp Pro Lys Ile Gln  Ala Leu Leu 
    2585                 2590                 2595             


Leu Thr  Val Leu Ala Thr Leu  Val Lys Tyr Thr Thr  Asp Glu Phe 
    2600                 2605                 2610             


Asp Gln  Arg Ile Leu Tyr Glu  Tyr Leu Ala Glu Ala  Ser Val Val 
    2615                 2620                 2625             


Phe Pro  Lys Val Phe Pro Val  Val His Asn Leu Leu  Asp Ser Lys 
    2630                 2635                 2640             


Ile Asn  Thr Leu Leu Ser Leu  Cys Gln Asp Pro Asn  Leu Leu Asn 
    2645                 2650                 2655             


Pro Ile  His Gly Ile Val Gln  Ser Val Val Tyr His  Glu Glu Ser 
    2660                 2665                 2670             


Pro Pro  Gln Tyr Gln Thr Ser  Tyr Leu Gln Ser Phe  Gly Phe Asn 
    2675                 2680                 2685             


Gly Leu  Trp Arg Phe Ala Gly  Pro Phe Ser Lys Gln  Thr Gln Ile 
    2690                 2695                 2700             


Pro Asp  Tyr Ala Glu Leu Ile  Val Lys Phe Leu Asp  Ala Leu Ile 
    2705                 2710                 2715             


Asp Thr  Tyr Leu Pro Gly Ile  Asp Glu Glu Thr Ser  Glu Glu Ser 
    2720                 2725                 2730             


Leu Leu  Thr Pro Thr Ser Pro  Tyr Pro Pro Ala Leu  Gln Ser Gln 
    2735                 2740                 2745             


Leu Ser  Ile Thr Ala Asn Leu  Asn Leu Ser Asn Ser  Met Thr Ser 
    2750                 2755                 2760             


Leu Ala  Thr Ser Gln His Ser  Pro Gly Ile Asp Lys  Glu Asn Val 
    2765                 2770                 2775             


Glu Leu  Ser Pro Thr Thr Gly  His Cys Asn Ser Gly  Arg Thr Arg 
    2780                 2785                 2790             


His Gly  Ser Ala Ser Gln Val  Gln Lys Gln Arg Ser  Ala Gly Ser 
    2795                 2800                 2805             


Phe Lys  Arg Asn Ser Ile Lys  Lys Ile Val 
    2810                 2815             


<210>  29
<211>  593
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Neurofibromin 1 Variant 3

<400>  29

Met Ala Ala His Arg Pro Val Glu Trp Val Gln Ala Val Val Ser Arg 
1               5                   10                  15      


Phe Asp Glu Gln Leu Pro Ile Lys Thr Gly Gln Gln Asn Thr His Thr 
            20                  25                  30          


Lys Val Ser Thr Glu His Asn Lys Glu Cys Leu Ile Asn Ile Ser Lys 
        35                  40                  45              


Tyr Lys Phe Ser Leu Val Ile Ser Gly Leu Thr Thr Ile Leu Lys Asn 
    50                  55                  60                  


Val Asn Asn Met Arg Ile Phe Gly Glu Ala Ala Glu Lys Asn Leu Tyr 
65                  70                  75                  80  


Leu Ser Gln Leu Ile Ile Leu Asp Thr Leu Glu Lys Cys Leu Ala Gly 
                85                  90                  95      


Gln Pro Lys Asp Thr Met Arg Leu Asp Glu Thr Met Leu Val Lys Gln 
            100                 105                 110         


Leu Leu Pro Glu Ile Cys His Phe Leu His Thr Cys Arg Glu Gly Asn 
        115                 120                 125             


Gln His Ala Ala Glu Leu Arg Asn Ser Ala Ser Gly Val Leu Phe Ser 
    130                 135                 140                 


Leu Ser Cys Asn Asn Phe Asn Ala Val Phe Ser Arg Ile Ser Thr Arg 
145                 150                 155                 160 


Leu Gln Glu Leu Thr Val Cys Ser Glu Asp Asn Val Asp Val His Asp 
                165                 170                 175     


Ile Glu Leu Leu Gln Tyr Ile Asn Val Asp Cys Ala Lys Leu Lys Arg 
            180                 185                 190         


Leu Leu Lys Glu Thr Ala Phe Lys Phe Lys Ala Leu Lys Lys Val Ala 
        195                 200                 205             


Gln Leu Ala Val Ile Asn Ser Leu Glu Lys Ala Phe Trp Asn Trp Val 
    210                 215                 220                 


Glu Asn Tyr Pro Asp Glu Phe Thr Lys Leu Tyr Gln Ile Pro Gln Thr 
225                 230                 235                 240 


Asp Met Ala Glu Cys Ala Glu Lys Leu Phe Asp Leu Val Asp Gly Phe 
                245                 250                 255     


Ala Glu Ser Thr Lys Arg Lys Ala Ala Val Trp Pro Leu Gln Ile Ile 
            260                 265                 270         


Leu Leu Ile Leu Cys Pro Glu Ile Ile Gln Asp Ile Ser Lys Asp Val 
        275                 280                 285             


Val Asp Glu Asn Asn Met Asn Lys Lys Leu Phe Leu Asp Ser Leu Arg 
    290                 295                 300                 


Lys Ala Leu Ala Gly His Gly Gly Ser Arg Gln Leu Thr Glu Ser Ala 
305                 310                 315                 320 


Ala Ile Ala Cys Val Lys Leu Cys Lys Ala Ser Thr Tyr Ile Asn Trp 
                325                 330                 335     


Glu Asp Asn Ser Val Ile Phe Leu Leu Val Gln Ser Met Val Val Asp 
            340                 345                 350         


Leu Lys Asn Leu Leu Phe Asn Pro Ser Lys Pro Phe Ser Arg Gly Ser 
        355                 360                 365             


Gln Pro Ala Asp Val Asp Leu Met Ile Asp Cys Leu Val Ser Cys Phe 
    370                 375                 380                 


Arg Ile Ser Pro His Asn Asn Gln His Phe Lys Ile Cys Leu Ala Gln 
385                 390                 395                 400 


Asn Ser Pro Ser Thr Phe His Tyr Val Leu Val Asn Ser Leu His Arg 
                405                 410                 415     


Ile Ile Thr Asn Ser Ala Leu Asp Trp Trp Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Tyr Cys His Ser Val Glu Leu Arg Asn Met Phe Gly Glu Thr Leu His 
        435                 440                 445             


Lys Ala Val Gln Gly Cys Gly Ala His Pro Ala Ile Arg Met Ala Pro 
    450                 455                 460                 


Ser Leu Thr Phe Lys Glu Lys Val Thr Ser Leu Lys Phe Lys Glu Lys 
465                 470                 475                 480 


Pro Thr Asp Leu Glu Thr Arg Ser Tyr Lys Tyr Leu Leu Leu Ser Met 
                485                 490                 495     


Val Lys Leu Ile His Ala Asp Pro Lys Leu Leu Leu Cys Asn Pro Arg 
            500                 505                 510         


Lys Gln Gly Pro Glu Thr Gln Gly Ser Thr Ala Glu Leu Ile Thr Gly 
        515                 520                 525             


Leu Val Gln Leu Val Pro Gln Ser His Met Pro Glu Ile Ala Gln Glu 
    530                 535                 540                 


Ala Met Glu Ala Leu Leu Val Leu His Gln Leu Asp Ser Ile Asp Leu 
545                 550                 555                 560 


Trp Asn Pro Asp Ala Pro Val Glu Thr Phe Trp Glu Ile Arg Tyr Met 
                565                 570                 575     


Tyr Phe Tyr Phe Leu Asn Ser Thr Phe Lys Phe Tyr Phe Val Phe Leu 
            580                 585                 590         


Ser 
    


<210>  30
<211>  2502
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Neurofibromin 1 Variant 4

<400>  30

Asn Trp Glu Asp Asn Ser Val Ile Phe Leu Leu Val Gln Ser Met Val 
1               5                   10                  15      


Val Asp Leu Lys Asn Leu Leu Phe Asn Pro Ser Lys Pro Phe Ser Arg 
            20                  25                  30          


Gly Ser Gln Pro Ala Asp Val Asp Leu Met Ile Asp Cys Leu Val Ser 
        35                  40                  45              


Cys Phe Arg Ile Ser Pro His Asn Asn Gln His Phe Lys Ile Cys Leu 
    50                  55                  60                  


Ala Gln Asn Ser Pro Ser Thr Phe His Tyr Val Leu Val Asn Ser Leu 
65                  70                  75                  80  


His Arg Ile Ile Thr Asn Ser Ala Leu Asp Trp Trp Pro Lys Ile Asp 
                85                  90                  95      


Ala Val Tyr Cys His Ser Val Glu Leu Arg Asn Met Phe Gly Glu Thr 
            100                 105                 110         


Leu His Lys Ala Val Gln Gly Cys Gly Ala His Pro Ala Ile Arg Met 
        115                 120                 125             


Ala Pro Ser Leu Thr Phe Lys Glu Lys Val Thr Ser Leu Lys Phe Lys 
    130                 135                 140                 


Glu Lys Pro Thr Asp Leu Glu Thr Arg Ser Tyr Lys Tyr Leu Leu Leu 
145                 150                 155                 160 


Ser Met Val Lys Leu Ile His Ala Asp Pro Lys Leu Leu Leu Cys Asn 
                165                 170                 175     


Pro Arg Lys Gln Gly Pro Glu Thr Gln Gly Ser Thr Ala Glu Leu Ile 
            180                 185                 190         


Thr Gly Leu Val Gln Leu Val Pro Gln Ser His Met Pro Glu Ile Ala 
        195                 200                 205             


Gln Glu Ala Met Glu Ala Leu Leu Val Leu His Gln Leu Asp Ser Ile 
    210                 215                 220                 


Asp Leu Trp Asn Pro Asp Ala Pro Val Glu Thr Phe Trp Glu Ile Ser 
225                 230                 235                 240 


Ser Gln Met Leu Phe Tyr Ile Cys Lys Lys Leu Thr Ser His Gln Met 
                245                 250                 255     


Leu Ser Ser Thr Glu Ile Leu Lys Trp Leu Arg Glu Ile Leu Ile Cys 
            260                 265                 270         


Arg Asn Lys Phe Leu Leu Lys Asn Lys Gln Ala Asp Arg Ser Ser Cys 
        275                 280                 285             


His Phe Leu Leu Phe Tyr Gly Val Gly Cys Asp Ile Pro Ser Ser Gly 
    290                 295                 300                 


Asn Thr Ser Gln Met Ser Met Asp His Glu Glu Leu Leu Arg Thr Pro 
305                 310                 315                 320 


Gly Ala Ser Leu Arg Lys Gly Lys Gly Asn Ser Ser Met Asp Ser Ala 
                325                 330                 335     


Ala Gly Cys Ser Gly Thr Pro Pro Ile Cys Arg Gln Ala Gln Thr Lys 
            340                 345                 350         


Leu Glu Val Ala Leu Tyr Met Phe Leu Trp Asn Pro Asp Thr Glu Ala 
        355                 360                 365             


Val Leu Val Ala Met Ser Cys Phe Arg His Leu Cys Glu Glu Ala Asp 
    370                 375                 380                 


Ile Arg Cys Gly Val Asp Glu Val Ser Val His Asn Leu Leu Pro Asn 
385                 390                 395                 400 


Tyr Asn Thr Phe Met Glu Phe Ala Ser Val Ser Asn Met Met Ser Thr 
                405                 410                 415     


Gly Arg Ala Ala Leu Gln Lys Arg Val Met Ala Leu Leu Arg Arg Ile 
            420                 425                 430         


Glu His Pro Thr Ala Gly Asn Thr Glu Ala Trp Glu Asp Thr His Ala 
        435                 440                 445             


Lys Trp Glu Gln Ala Thr Lys Leu Ile Leu Asn Tyr Pro Lys Ala Lys 
    450                 455                 460                 


Met Glu Asp Gly Gln Ala Ala Glu Ser Leu His Lys Thr Ile Val Lys 
465                 470                 475                 480 


Arg Arg Met Ser His Val Ser Gly Gly Gly Ser Ile Asp Leu Ser Asp 
                485                 490                 495     


Thr Asp Ser Leu Gln Glu Trp Ile Asn Met Thr Gly Phe Leu Cys Ala 
            500                 505                 510         


Leu Gly Gly Val Cys Leu Gln Gln Arg Ser Asn Ser Gly Leu Ala Thr 
        515                 520                 525             


Tyr Ser Pro Pro Met Gly Pro Val Ser Glu Arg Lys Gly Ser Met Ile 
    530                 535                 540                 


Ser Val Met Ser Ser Glu Gly Asn Ala Asp Thr Pro Val Ser Lys Phe 
545                 550                 555                 560 


Met Asp Arg Leu Leu Ser Leu Met Val Cys Asn His Glu Lys Val Gly 
                565                 570                 575     


Leu Gln Ile Arg Thr Asn Val Lys Asp Leu Val Gly Leu Glu Leu Ser 
            580                 585                 590         


Pro Ala Leu Tyr Pro Met Leu Phe Asn Lys Leu Lys Asn Thr Ile Ser 
        595                 600                 605             


Lys Phe Phe Asp Ser Gln Gly Gln Val Leu Leu Thr Asp Thr Asn Thr 
    610                 615                 620                 


Gln Phe Val Glu Gln Thr Ile Ala Ile Met Lys Asn Leu Leu Asp Asn 
625                 630                 635                 640 


His Thr Glu Gly Ser Ser Glu His Leu Gly Gln Ala Ser Ile Glu Thr 
                645                 650                 655     


Met Met Leu Asn Leu Val Arg Tyr Val Arg Val Leu Gly Asn Met Val 
            660                 665                 670         


His Ala Ile Gln Ile Lys Thr Lys Leu Cys Gln Leu Val Glu Val Met 
        675                 680                 685             


Met Ala Arg Arg Asp Asp Leu Ser Phe Cys Gln Glu Met Lys Phe Arg 
    690                 695                 700                 


Asn Lys Met Val Glu Tyr Leu Thr Asp Trp Val Met Gly Thr Ser Asn 
705                 710                 715                 720 


Gln Ala Ala Asp Asp Asp Val Lys Cys Leu Thr Arg Asp Leu Asp Gln 
                725                 730                 735     


Ala Ser Met Glu Ala Val Val Ser Leu Leu Ala Gly Leu Pro Leu Gln 
            740                 745                 750         


Pro Glu Glu Gly Asp Gly Val Glu Leu Met Glu Ala Lys Ser Gln Leu 
        755                 760                 765             


Phe Leu Lys Tyr Phe Thr Leu Phe Met Asn Leu Leu Asn Asp Cys Ser 
    770                 775                 780                 


Glu Val Glu Asp Glu Ser Ala Gln Thr Gly Gly Arg Lys Arg Gly Met 
785                 790                 795                 800 


Ser Arg Arg Leu Ala Ser Leu Arg His Cys Thr Val Leu Ala Met Ser 
                805                 810                 815     


Asn Leu Leu Asn Ala Asn Val Asp Ser Gly Leu Met His Ser Ile Gly 
            820                 825                 830         


Leu Gly Tyr His Lys Asp Leu Gln Thr Arg Ala Thr Phe Met Glu Val 
        835                 840                 845             


Leu Thr Lys Ile Leu Gln Gln Gly Thr Glu Phe Asp Thr Leu Ala Glu 
    850                 855                 860                 


Thr Val Leu Ala Asp Arg Phe Glu Arg Leu Val Glu Leu Val Thr Met 
865                 870                 875                 880 


Met Gly Asp Gln Gly Glu Leu Pro Ile Ala Met Ala Leu Ala Asn Val 
                885                 890                 895     


Val Pro Cys Ser Gln Trp Asp Glu Leu Ala Arg Val Leu Val Thr Leu 
            900                 905                 910         


Phe Asp Ser Arg His Leu Leu Tyr Gln Leu Leu Trp Asn Met Phe Ser 
        915                 920                 925             


Lys Glu Val Glu Leu Ala Asp Ser Met Gln Thr Leu Phe Arg Gly Asn 
    930                 935                 940                 


Ser Leu Ala Ser Lys Ile Met Thr Phe Cys Phe Lys Val Tyr Gly Ala 
945                 950                 955                 960 


Thr Tyr Leu Gln Lys Leu Leu Asp Pro Leu Leu Arg Ile Val Ile Thr 
                965                 970                 975     


Ser Ser Asp Trp Gln His Val Ser Phe Glu Val Asp Pro Thr Arg Leu 
            980                 985                 990         


Glu Pro Ser Glu Ser Leu Glu Glu  Asn Gln Arg Asn Leu  Leu Gln Met 
        995                 1000                 1005             


Thr Glu  Lys Phe Phe His Ala  Ile Ile Ser Ser Ser  Ser Glu Phe 
    1010                 1015                 1020             


Pro Pro  Gln Leu Arg Ser Val  Cys His Cys Leu Tyr  Gln Val Val 
    1025                 1030                 1035             


Ser Gln  Arg Phe Pro Gln Asn  Ser Ile Gly Ala Val  Gly Ser Ala 
    1040                 1045                 1050             


Met Phe  Leu Arg Phe Ile Asn  Pro Ala Ile Val Ser  Pro Tyr Glu 
    1055                 1060                 1065             


Ala Gly  Ile Leu Asp Lys Lys  Pro Pro Pro Arg Ile  Glu Arg Gly 
    1070                 1075                 1080             


Leu Lys  Leu Met Ser Lys Ile  Leu Gln Ser Ile Ala  Asn His Val 
    1085                 1090                 1095             


Leu Phe  Thr Lys Glu Glu His  Met Arg Pro Phe Asn  Asp Phe Val 
    1100                 1105                 1110             


Lys Ser  Asn Phe Asp Ala Ala  Arg Arg Phe Phe Leu  Asp Ile Ala 
    1115                 1120                 1125             


Ser Asp  Cys Pro Thr Ser Asp  Ala Val Asn His Ser  Leu Ser Phe 
    1130                 1135                 1140             


Ile Ser  Asp Gly Asn Val Leu  Ala Leu His Arg Leu  Leu Trp Asn 
    1145                 1150                 1155             


Asn Gln  Glu Lys Ile Gly Gln  Tyr Leu Ser Ser Asn  Arg Asp His 
    1160                 1165                 1170             


Lys Ala  Val Gly Arg Arg Pro  Phe Asp Lys Met Ala  Thr Leu Leu 
    1175                 1180                 1185             


Ala Tyr  Leu Gly Pro Pro Glu  His Lys Pro Val Ala  Asp Thr His 
    1190                 1195                 1200             


Trp Ser  Ser Leu Asn Leu Thr  Ser Ser Lys Phe Glu  Glu Phe Met 
    1205                 1210                 1215             


Thr Arg  His Gln Val His Glu  Lys Glu Glu Phe Lys  Ala Leu Lys 
    1220                 1225                 1230             


Thr Leu  Ser Ile Phe Tyr Gln  Ala Gly Thr Ser Lys  Ala Gly Asn 
    1235                 1240                 1245             


Pro Ile  Phe Tyr Tyr Val Ala  Arg Arg Phe Lys Thr  Gly Gln Ile 
    1250                 1255                 1260             


Asn Gly  Asp Leu Leu Ile Tyr  His Val Leu Leu Thr  Leu Lys Pro 
    1265                 1270                 1275             


Tyr Tyr  Ala Lys Pro Tyr Glu  Ile Val Val Asp Leu  Thr His Thr 
    1280                 1285                 1290             


Gly Pro  Ser Asn Arg Phe Lys  Thr Asp Phe Leu Ser  Lys Trp Phe 
    1295                 1300                 1305             


Val Val  Phe Pro Gly Phe Ala  Tyr Asp Asn Val Ser  Ala Val Tyr 
    1310                 1315                 1320             


Ile Tyr  Asn Cys Asn Ser Trp  Val Arg Glu Tyr Thr  Lys Tyr His 
    1325                 1330                 1335             


Glu Arg  Leu Leu Thr Gly Leu  Lys Gly Ser Lys Arg  Leu Val Phe 
    1340                 1345                 1350             


Ile Asp  Cys Pro Gly Lys Leu  Ala Glu His Ile Glu  His Glu Gln 
    1355                 1360                 1365             


Gln Lys  Leu Pro Ala Ala Thr  Leu Ala Leu Glu Glu  Asp Leu Lys 
    1370                 1375                 1380             


Val Phe  His Asn Ala Leu Lys  Leu Ala His Lys Asp  Thr Lys Val 
    1385                 1390                 1395             


Ser Ile  Lys Val Gly Ser Thr  Ala Val Gln Val Thr  Ser Ala Glu 
    1400                 1405                 1410             


Arg Thr  Lys Val Leu Gly Gln  Ser Val Phe Leu Asn  Asp Ile Tyr 
    1415                 1420                 1425             


Tyr Ala  Ser Glu Ile Glu Glu  Ile Cys Leu Val Asp  Glu Asn Gln 
    1430                 1435                 1440             


Phe Thr  Leu Thr Ile Ala Asn  Gln Gly Thr Pro Leu  Thr Phe Met 
    1445                 1450                 1455             


His Gln  Glu Cys Glu Ala Ile  Val Gln Ser Ile Ile  His Ile Arg 
    1460                 1465                 1470             


Thr Arg  Trp Glu Leu Ser Gln  Pro Asp Ser Ile Pro  Gln His Thr 
    1475                 1480                 1485             


Lys Ile  Arg Pro Lys Asp Val  Pro Gly Thr Leu Leu  Asn Ile Ala 
    1490                 1495                 1500             


Leu Leu  Asn Leu Gly Ser Ser  Asp Pro Ser Leu Arg  Ser Ala Ala 
    1505                 1510                 1515             


Tyr Asn  Leu Leu Cys Ala Leu  Thr Cys Thr Phe Asn  Leu Lys Ile 
    1520                 1525                 1530             


Glu Gly  Gln Leu Leu Glu Thr  Ser Gly Leu Cys Ile  Pro Ala Asn 
    1535                 1540                 1545             


Asn Thr  Leu Phe Ile Val Ser  Ile Ser Lys Thr Leu  Ala Ala Asn 
    1550                 1555                 1560             


Glu Pro  His Leu Thr Leu Glu  Phe Leu Glu Glu Cys  Ile Ser Gly 
    1565                 1570                 1575             


Phe Ser  Lys Ser Ser Ile Glu  Leu Lys His Leu Cys  Leu Glu Tyr 
    1580                 1585                 1590             


Met Thr  Pro Trp Leu Ser Asn  Leu Val Arg Phe Cys  Lys His Asn 
    1595                 1600                 1605             


Asp Asp  Ala Lys Arg Gln Arg  Val Thr Ala Ile Leu  Asp Lys Leu 
    1610                 1615                 1620             


Ile Thr  Met Thr Ile Asn Glu  Lys Gln Met Tyr Pro  Ser Ile Gln 
    1625                 1630                 1635             


Ala Lys  Ile Trp Gly Ser Leu  Gly Gln Ile Thr Asp  Leu Leu Asp 
    1640                 1645                 1650             


Val Val  Leu Asp Ser Phe Ile  Lys Thr Ser Ala Thr  Gly Gly Leu 
    1655                 1660                 1665             


Gly Ser  Ile Lys Ala Glu Val  Met Ala Asp Thr Ala  Val Ala Leu 
    1670                 1675                 1680             


Ala Ser  Gly Asn Val Lys Leu  Val Ser Ser Lys Val  Ile Gly Arg 
    1685                 1690                 1695             


Met Cys  Lys Ile Ile Asp Lys  Thr Cys Leu Ser Pro  Thr Pro Thr 
    1700                 1705                 1710             


Leu Glu  Gln His Leu Met Trp  Asp Asp Ile Ala Ile  Leu Ala Arg 
    1715                 1720                 1725             


Tyr Met  Leu Met Leu Ser Phe  Asn Asn Ser Leu Asp  Val Ala Ala 
    1730                 1735                 1740             


His Leu  Pro Tyr Leu Phe His  Val Val Thr Phe Leu  Val Ala Thr 
    1745                 1750                 1755             


Gly Pro  Leu Ser Leu Arg Ala  Ser Thr His Gly Leu  Val Ile Asn 
    1760                 1765                 1770             


Ile Ile  His Ser Leu Cys Thr  Cys Ser Gln Leu His  Phe Ser Glu 
    1775                 1780                 1785             


Glu Thr  Lys Gln Val Leu Arg  Leu Ser Leu Thr Glu  Phe Ser Leu 
    1790                 1795                 1800             


Pro Lys  Phe Tyr Leu Leu Phe  Gly Ile Ser Lys Val  Lys Ser Ala 
    1805                 1810                 1815             


Ala Val  Ile Ala Phe Arg Ser  Ser Tyr Arg Asp Arg  Ser Phe Ser 
    1820                 1825                 1830             


Pro Gly  Ser Tyr Glu Arg Glu  Thr Phe Ala Leu Thr  Ser Leu Glu 
    1835                 1840                 1845             


Thr Val  Thr Glu Ala Leu Leu  Glu Ile Met Glu Ala  Cys Met Arg 
    1850                 1855                 1860             


Asp Ile  Pro Thr Cys Lys Trp  Leu Asp Gln Trp Thr  Glu Leu Ala 
    1865                 1870                 1875             


Gln Arg  Phe Ala Phe Gln Tyr  Asn Pro Ser Leu Gln  Pro Arg Ala 
    1880                 1885                 1890             


Leu Val  Val Phe Gly Cys Ile  Ser Lys Arg Val Ser  His Gly Gln 
    1895                 1900                 1905             


Ile Lys  Gln Ile Ile Arg Ile  Leu Ser Lys Ala Leu  Glu Ser Cys 
    1910                 1915                 1920             


Leu Lys  Gly Pro Asp Thr Tyr  Asn Ser Gln Val Leu  Ile Glu Ala 
    1925                 1930                 1935             


Thr Val  Ile Ala Leu Thr Lys  Leu Gln Pro Leu Leu  Asn Lys Asp 
    1940                 1945                 1950             


Ser Pro  Leu His Lys Ala Leu  Phe Trp Val Ala Val  Ala Val Leu 
    1955                 1960                 1965             


Gln Leu  Asp Glu Val Asn Leu  Tyr Ser Ala Gly Thr  Ala Leu Leu 
    1970                 1975                 1980             


Glu Gln  Asn Leu His Thr Leu  Asp Ser Leu Arg Ile  Phe Asn Asp 
    1985                 1990                 1995             


Lys Ser  Pro Glu Glu Val Phe  Met Ala Ile Arg Asn  Pro Leu Glu 
    2000                 2005                 2010             


Trp His  Cys Lys Gln Met Asp  His Phe Val Gly Leu  Asn Phe Asn 
    2015                 2020                 2025             


Ser Asn  Phe Asn Phe Ala Leu  Val Gly His Leu Leu  Lys Gly Tyr 
    2030                 2035                 2040             


Arg His  Pro Ser Pro Ala Ile  Val Ala Arg Thr Val  Arg Ile Leu 
    2045                 2050                 2055             


His Thr  Leu Leu Thr Leu Val  Asn Lys His Arg Asn  Cys Asp Lys 
    2060                 2065                 2070             


Phe Glu  Val Asn Thr Gln Ser  Val Ala Tyr Leu Ala  Ala Leu Leu 
    2075                 2080                 2085             


Thr Val  Ser Glu Glu Val Arg  Ser Arg Cys Ser Leu  Lys His Arg 
    2090                 2095                 2100             


Lys Ser  Leu Leu Leu Thr Asp  Ile Ser Met Glu Asn  Val Pro Met 
    2105                 2110                 2115             


Asp Thr  Tyr Pro Ile His His  Gly Asp Pro Ser Tyr  Arg Thr Leu 
    2120                 2125                 2130             


Lys Glu  Thr Gln Pro Trp Ser  Ser Pro Lys Gly Ser  Glu Gly Tyr 
    2135                 2140                 2145             


Leu Ala  Ala Thr Tyr Pro Thr  Val Gly Gln Thr Ser  Pro Arg Ala 
    2150                 2155                 2160             


Arg Lys  Ser Met Ser Leu Asp  Met Gly Gln Pro Ser  Gln Ala Asn 
    2165                 2170                 2175             


Thr Lys  Lys Leu Leu Gly Thr  Arg Lys Ser Phe Asp  His Leu Ile 
    2180                 2185                 2190             


Ser Asp  Thr Lys Ala Pro Lys  Arg Gln Glu Met Glu  Ser Gly Ile 
    2195                 2200                 2205             


Thr Thr  Pro Pro Lys Met Arg  Arg Val Ala Glu Thr  Asp Tyr Glu 
    2210                 2215                 2220             


Met Glu  Thr Gln Arg Ile Ser  Ser Ser Gln Gln His  Pro His Leu 
    2225                 2230                 2235             


Arg Lys  Val Ser Val Ser Glu  Ser Asn Val Leu Leu  Asp Glu Glu 
    2240                 2245                 2250             


Val Leu  Thr Asp Pro Lys Ile  Gln Ala Leu Leu Leu  Thr Val Leu 
    2255                 2260                 2265             


Ala Thr  Leu Val Lys Tyr Thr  Thr Asp Glu Phe Asp  Gln Arg Ile 
    2270                 2275                 2280             


Leu Tyr  Glu Tyr Leu Ala Glu  Ala Ser Val Val Phe  Pro Lys Val 
    2285                 2290                 2295             


Phe Pro  Val Val His Asn Leu  Leu Asp Ser Lys Ile  Asn Thr Leu 
    2300                 2305                 2310             


Leu Ser  Leu Cys Gln Asp Pro  Asn Leu Leu Asn Pro  Ile His Gly 
    2315                 2320                 2325             


Ile Val  Gln Ser Val Val Tyr  His Glu Glu Ser Pro  Pro Gln Tyr 
    2330                 2335                 2340             


Gln Thr  Ser Tyr Leu Gln Ser  Phe Gly Phe Asn Gly  Leu Trp Arg 
    2345                 2350                 2355             


Phe Ala  Gly Pro Phe Ser Lys  Gln Thr Gln Ile Pro  Asp Tyr Ala 
    2360                 2365                 2370             


Glu Leu  Ile Val Lys Phe Leu  Asp Ala Leu Ile Asp  Thr Tyr Leu 
    2375                 2380                 2385             


Pro Gly  Ile Asp Glu Glu Thr  Ser Glu Glu Ser Leu  Leu Thr Pro 
    2390                 2395                 2400             


Thr Ser  Pro Tyr Pro Pro Ala  Leu Gln Ser Gln Leu  Ser Ile Thr 
    2405                 2410                 2415             


Ala Asn  Leu Asn Leu Ser Asn  Ser Met Thr Ser Leu  Ala Thr Ser 
    2420                 2425                 2430             


Gln His  Ser Pro Ala Ser Leu  Pro Cys Ser Lys Ser  Ala Val Phe 
    2435                 2440                 2445             


Met Gln  Leu Phe Pro His Gln  Gly Ile Asp Lys Glu  Asn Val Glu 
    2450                 2455                 2460             


Leu Ser  Pro Thr Thr Gly His  Cys Asn Ser Gly Arg  Thr Arg His 
    2465                 2470                 2475             


Gly Ser  Ala Ser Gln Val Gln  Lys Gln Arg Ser Ala  Gly Ser Phe 
    2480                 2485                 2490             


Lys Arg  Asn Ser Ile Lys Lys  Ile Val 
    2495                 2500         


<210>  31
<211>  551
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Neurofibromin 1 Variant 5

<400>  31

Met Ala Ala His Arg Pro Val Glu Trp Val Gln Ala Val Val Ser Arg 
1               5                   10                  15      


Phe Asp Glu Gln Leu Pro Ile Lys Thr Gly Gln Gln Asn Thr His Thr 
            20                  25                  30          


Lys Val Ser Thr Glu His Asn Lys Glu Cys Leu Ile Asn Ile Ser Lys 
        35                  40                  45              


Tyr Lys Phe Ser Leu Val Ile Ser Gly Leu Thr Thr Ile Leu Lys Asn 
    50                  55                  60                  


Val Asn Asn Met Arg Ile Phe Gly Glu Ala Ala Glu Lys Asn Leu Tyr 
65                  70                  75                  80  


Leu Ser Gln Leu Ile Ile Leu Asp Thr Leu Glu Lys Cys Leu Ala Gly 
                85                  90                  95      


Gln Pro Lys Asp Thr Met Arg Leu Asp Glu Thr Met Leu Val Lys Gln 
            100                 105                 110         


Leu Leu Pro Glu Ile Cys His Phe Leu His Thr Cys Arg Glu Gly Asn 
        115                 120                 125             


Gln His Ala Ala Glu Leu Arg Asn Ser Ala Ser Gly Val Leu Phe Ser 
    130                 135                 140                 


Leu Ser Cys Asn Asn Phe Asn Ala Val Phe Ser Arg Ile Ser Thr Arg 
145                 150                 155                 160 


Leu Gln Glu Leu Thr Val Cys Ser Glu Asp Asn Val Asp Val His Asp 
                165                 170                 175     


Ile Glu Leu Leu Gln Tyr Ile Asn Val Asp Cys Ala Lys Leu Lys Arg 
            180                 185                 190         


Leu Leu Lys Glu Thr Ala Phe Lys Phe Lys Ala Leu Lys Lys Val Ala 
        195                 200                 205             


Gln Leu Ala Val Ile Asn Ser Leu Glu Lys Ala Phe Trp Asn Trp Val 
    210                 215                 220                 


Glu Asn Tyr Pro Asp Glu Phe Thr Lys Leu Tyr Gln Ile Pro Gln Thr 
225                 230                 235                 240 


Asp Met Ala Glu Cys Ala Glu Lys Leu Phe Asp Leu Val Asp Gly Phe 
                245                 250                 255     


Ala Glu Ser Thr Lys Arg Lys Ala Ala Val Trp Pro Leu Gln Ile Ile 
            260                 265                 270         


Leu Leu Ile Leu Cys Pro Glu Ile Ile Gln Asp Ile Ser Lys Asp Val 
        275                 280                 285             


Val Asp Glu Asn Asn Met Asn Lys Lys Leu Phe Leu Asp Ser Leu Arg 
    290                 295                 300                 


Lys Ala Leu Ala Gly His Gly Gly Ser Arg Gln Leu Thr Glu Ser Ala 
305                 310                 315                 320 


Ala Ile Ala Cys Val Lys Leu Cys Lys Ala Ser Thr Tyr Ile Asn Trp 
                325                 330                 335     


Glu Asp Asn Ser Val Ile Phe Leu Leu Val Gln Ser Met Val Val Asp 
            340                 345                 350         


Leu Lys Asn Leu Leu Phe Asn Pro Ser Lys Pro Phe Ser Arg Gly Ser 
        355                 360                 365             


Gln Pro Ala Asp Val Asp Leu Met Ile Asp Cys Leu Val Ser Cys Phe 
    370                 375                 380                 


Arg Ile Ser Pro His Asn Asn Gln His Phe Lys Ile Cys Leu Ala Gln 
385                 390                 395                 400 


Asn Ser Pro Ser Thr Phe His Tyr Val Leu Val Asn Ser Leu His Arg 
                405                 410                 415     


Ile Ile Thr Asn Ser Ala Leu Asp Trp Trp Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Tyr Cys His Ser Val Glu Leu Arg Asn Met Phe Gly Glu Thr Leu His 
        435                 440                 445             


Lys Ala Val Gln Gly Cys Gly Ala His Pro Ala Ile Arg Met Ala Pro 
    450                 455                 460                 


Ser Leu Thr Phe Lys Glu Lys Val Thr Ser Leu Lys Phe Lys Glu Lys 
465                 470                 475                 480 


Pro Thr Asp Leu Glu Thr Arg Ser Tyr Lys Tyr Leu Leu Leu Ser Met 
                485                 490                 495     


Val Lys Leu Ile His Ala Asp Pro Lys Leu Leu Leu Cys Asn Pro Arg 
            500                 505                 510         


Lys Gln Gly Pro Glu Thr Gln Gly Ser Thr Ala Glu Leu Ile Thr Gly 
        515                 520                 525             


Leu Val Gln Leu Val Pro Gln Ser His Met Pro Glu Ile Ala Gln Glu 
    530                 535                 540                 


Ala Met Glu Val Arg Gly Lys 
545                 550     


<210>  32
<211>  237
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Neurofibromin 1 Variant 6

<400>  32

Met His Gln Glu Cys Glu Ala Ile Val Gln Ser Ile Ile His Ile Arg 
1               5                   10                  15      


Thr Arg Trp Glu Leu Ser Gln Pro Asp Ser Ile Pro Gln His Thr Lys 
            20                  25                  30          


Ile Arg Pro Lys Asp Val Pro Gly Thr Leu Leu Asn Ile Ala Leu Leu 
        35                  40                  45              


Asn Leu Gly Ser Ser Asp Pro Ser Leu Arg Ser Ala Ala Tyr Asn Leu 
    50                  55                  60                  


Leu Cys Ala Leu Thr Cys Thr Phe Asn Leu Lys Ile Glu Gly Gln Leu 
65                  70                  75                  80  


Leu Glu Thr Ser Gly Leu Cys Ile Pro Ala Asn Asn Thr Leu Phe Ile 
                85                  90                  95      


Val Ser Ile Ser Lys Thr Leu Ala Ala Asn Glu Pro His Leu Thr Leu 
            100                 105                 110         


Glu Phe Leu Glu Glu Cys Ile Ser Gly Phe Ser Lys Ser Ser Ile Glu 
        115                 120                 125             


Leu Lys His Leu Cys Leu Glu Tyr Met Thr Pro Trp Leu Ser Asn Leu 
    130                 135                 140                 


Val Arg Phe Cys Lys His Asn Asp Asp Ala Lys Arg Gln Arg Val Thr 
145                 150                 155                 160 


Ala Ile Leu Asp Lys Leu Ile Thr Met Thr Ile Asn Glu Lys Gln Met 
                165                 170                 175     


Tyr Pro Ser Ile Gln Ala Lys Ile Trp Gly Ser Leu Gly Gln Ile Thr 
            180                 185                 190         


Asp Leu Leu Asp Val Val Leu Asp Ser Phe Ile Lys Thr Ser Ala Thr 
        195                 200                 205             


Gly Gly Leu Gly Ser Ile Lys Ala Glu Val Met Ala Asp Thr Ala Val 
    210                 215                 220                 


Ala Leu Ala Ser Gly Asn Val Lys Leu Val Ser Ser Lys 
225                 230                 235         


<210>  33
<211>  233
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Neurofibromin 1 Variant 6

<400>  33

Met Lys Arg Cys Trp Ser Asn Ser Cys Cys Gln Lys Ser Ala Ile Phe 
1               5                   10                  15      


Phe Thr Pro Val Val Lys Glu Thr Ser Met Gln Leu Asn Phe Gly Ile 
            20                  25                  30          


Leu Pro Leu Gly Phe Tyr Phe Leu Ser Ala Ala Thr Thr Ser Met Gln 
        35                  40                  45              


Ser Leu Val Ala Phe Leu Pro Glu Thr Ala Phe Lys Phe Lys Ala Leu 
    50                  55                  60                  


Lys Lys Val Ala Gln Leu Ala Val Ile Asn Ser Leu Glu Lys Ala Phe 
65                  70                  75                  80  


Trp Asn Trp Val Glu Asn Tyr Pro Asp Glu Phe Thr Lys Leu Tyr Gln 
                85                  90                  95      


Ile Pro Gln Thr Asp Met Ala Glu Cys Ala Glu Lys Leu Phe Asp Leu 
            100                 105                 110         


Val Asp Gly Phe Ala Glu Ser Thr Lys Arg Lys Ala Ala Val Trp Pro 
        115                 120                 125             


Leu Gln Ile Ile Leu Leu Ile Leu Cys Pro Glu Ile Ile Gln Asp Ile 
    130                 135                 140                 


Ser Lys Asp Val Val Asp Glu Asn Asn Met Asn Lys Val Arg Arg Ala 
145                 150                 155                 160 


Lys Leu Phe Pro Leu Tyr Leu Asp Val Lys Gln Phe Ile Leu Leu Lys 
                165                 170                 175     


Val Cys Ile Thr Leu Gly Leu Leu Phe Lys Gln Ser Ile Ser Gly Asn 
            180                 185                 190         


His Leu Asn Asp His Phe Arg Phe Leu Cys Leu Met Asp Leu Glu Glu 
        195                 200                 205             


Thr Tyr Ser Tyr Ile Ile Leu Phe Gly Arg Gly Lys Ile Ile Pro Gly 
    210                 215                 220                 


Asn Glu Gln Arg Phe Lys Ile Ile Pro 
225                 230             


<210>  34
<211>  115
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Neurofibromin 1 Variant 8

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  34

Xaa Ile His Gly Ile Val Gln Ser Val Val Tyr His Glu Glu Ser Pro 
1               5                   10                  15      


Pro Gln Tyr Gln Thr Ser Tyr Leu Gln Ser Phe Gly Phe Asn Gly Leu 
            20                  25                  30          


Trp Arg Phe Ala Gly Pro Phe Ser Lys Gln Thr Gln Ile Pro Asp Tyr 
        35                  40                  45              


Ala Glu Leu Ile Val Lys Phe Leu Asp Ala Leu Ile Asp Thr Tyr Leu 
    50                  55                  60                  


Pro Gly Ile Asp Glu Glu Thr Ser Glu Glu Ser Leu Leu Thr Pro Thr 
65                  70                  75                  80  


Ser Pro Tyr Pro Pro Ala Leu Gln Ser Gln Leu Ser Ile Thr Ala Asn 
                85                  90                  95      


Leu Asn Leu Ser Asn Ser Met Thr Ser Leu Ala Thr Ser Gln His Ser 
            100                 105                 110         


Pro Gly Gln 
        115 


<210>  35
<211>  293
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Glyceraldehyde-3 phosphate dehydrogenase Variant 2

<400>  35

Met Val Tyr Met Phe Gln Tyr Asp Ser Thr His Gly Lys Phe His Gly 
1               5                   10                  15      


Thr Val Lys Ala Glu Asn Gly Lys Leu Val Ile Asn Gly Asn Pro Ile 
            20                  25                  30          


Thr Ile Phe Gln Glu Arg Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala 
        35                  40                  45              


Gly Ala Glu Tyr Val Val Glu Ser Thr Gly Val Phe Thr Thr Met Glu 
    50                  55                  60                  


Lys Ala Gly Ala His Leu Gln Gly Gly Ala Lys Arg Val Ile Ile Ser 
65                  70                  75                  80  


Ala Pro Ser Ala Asp Ala Pro Met Phe Val Met Gly Val Asn His Glu 
                85                  90                  95      


Lys Tyr Asp Asn Ser Leu Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr 
            100                 105                 110         


Asn Cys Leu Ala Pro Leu Ala Lys Val Ile His Asp Asn Phe Gly Ile 
        115                 120                 125             


Val Glu Gly Leu Met Thr Thr Val His Ala Ile Thr Ala Thr Gln Lys 
    130                 135                 140                 


Thr Val Asp Gly Pro Ser Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala 
145                 150                 155                 160 


Leu Gln Asn Ile Ile Pro Ala Ser Thr Gly Ala Ala Lys Ala Val Gly 
                165                 170                 175     


Lys Val Ile Pro Glu Leu Asn Gly Lys Leu Thr Gly Met Ala Phe Arg 
            180                 185                 190         


Val Pro Thr Ala Asn Val Ser Val Val Asp Leu Thr Cys Arg Leu Glu 
        195                 200                 205             


Lys Pro Ala Lys Tyr Asp Asp Ile Lys Lys Val Val Lys Gln Ala Ser 
    210                 215                 220                 


Glu Gly Pro Leu Lys Gly Ile Leu Gly Tyr Thr Glu His Gln Val Val 
225                 230                 235                 240 


Ser Ser Asp Phe Asn Ser Asp Thr His Ser Ser Thr Phe Asp Ala Gly 
                245                 250                 255     


Ala Gly Ile Ala Leu Asn Asp His Phe Val Lys Leu Ile Ser Trp Tyr 
            260                 265                 270         


Asp Asn Glu Phe Gly Tyr Ser Asn Arg Val Val Asp Leu Met Ala His 
        275                 280                 285             


Met Ala Ser Lys Glu 
    290             


<210>  36
<211>  335
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Glyceraldehyde-3 phosphate dehydrogenase Variant 3

<400>  36

Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Arg Ile Gly Arg 
1               5                   10                  15      


Leu Val Thr Arg Ala Ala Phe Asn Ser Gly Lys Val Asp Ile Val Ala 
            20                  25                  30          


Ile Asn Asp Pro Phe Ile Asp Leu Asn Tyr Met Val Tyr Met Phe Gln 
        35                  40                  45              


Tyr Asp Ser Thr His Gly Lys Phe His Gly Thr Val Lys Ala Glu Asn 
    50                  55                  60                  


Gly Lys Leu Val Ile Asn Gly Asn Pro Ile Thr Ile Phe Gln Glu Arg 
65                  70                  75                  80  


Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala Gly Ala Glu Tyr Val Val 
                85                  90                  95      


Glu Ser Thr Gly Val Phe Thr Thr Met Glu Lys Ala Gly Ala His Leu 
            100                 105                 110         


Gln Gly Gly Ala Lys Arg Val Ile Ile Ser Ala Pro Ser Ala Asp Ala 
        115                 120                 125             


Pro Met Phe Val Met Gly Val Asn His Glu Lys Tyr Asp Asn Ser Leu 
    130                 135                 140                 


Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu 
145                 150                 155                 160 


Ala Lys Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met Thr 
                165                 170                 175     


Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser 
            180                 185                 190         


Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala Leu Gln Asn Ile Ile Pro 
        195                 200                 205             


Ala Ser Thr Gly Ala Ala Lys Ala Val Gly Lys Val Ile Pro Glu Leu 
    210                 215                 220                 


Asn Gly Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Ala Asn Val 
225                 230                 235                 240 


Ser Val Val Asp Leu Thr Cys Arg Leu Glu Lys Pro Ala Lys Tyr Asp 
                245                 250                 255     


Asp Ile Lys Lys Val Val Lys Gln Ala Ser Glu Gly Pro Leu Lys Gly 
            260                 265                 270         


Ile Leu Gly Tyr Thr Glu His Gln Val Val Ser Ser Asp Phe Asn Ser 
        275                 280                 285             


Asp Thr His Ser Ser Thr Phe Asp Ala Gly Ala Gly Ile Ala Leu Asn 
    290                 295                 300                 


Asp His Phe Val Lys Leu Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr 
305                 310                 315                 320 


Ser Asn Arg Val Val Asp Leu Met Ala His Met Ala Ser Lys Glu 
                325                 330                 335 


<210>  37
<211>  335
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Glyceraldehyde-3 phosphate dehydrogenase Variant 4

<400>  37

Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Arg Ile Gly Arg 
1               5                   10                  15      


Leu Val Thr Arg Ala Ala Phe Asn Ser Gly Lys Val Asp Ile Val Ala 
            20                  25                  30          


Ile Asn Asp Pro Phe Ile Asp Leu Asn Tyr Met Val Tyr Met Phe Gln 
        35                  40                  45              


Tyr Asp Ser Thr His Gly Lys Phe His Gly Thr Val Lys Ala Glu Asn 
    50                  55                  60                  


Gly Lys Leu Val Ile Asn Gly Asn Pro Ile Thr Ile Phe Gln Glu Arg 
65                  70                  75                  80  


Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala Gly Ala Glu Tyr Val Val 
                85                  90                  95      


Glu Ser Thr Gly Val Phe Thr Thr Met Glu Lys Ala Gly Ala His Leu 
            100                 105                 110         


Gln Gly Gly Ala Lys Arg Val Ile Ile Ser Ala Pro Ser Ala Asp Ala 
        115                 120                 125             


Pro Met Phe Val Met Gly Val Asn His Glu Lys Tyr Asp Asn Ser Leu 
    130                 135                 140                 


Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu 
145                 150                 155                 160 


Ala Lys Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met Thr 
                165                 170                 175     


Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser 
            180                 185                 190         


Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala Leu Gln Asn Ile Ile Pro 
        195                 200                 205             


Ala Ser Thr Gly Ala Ala Lys Ala Val Gly Lys Val Ile Pro Glu Leu 
    210                 215                 220                 


Asn Gly Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Ala Asn Val 
225                 230                 235                 240 


Ser Val Val Asp Leu Thr Cys Arg Leu Glu Lys Pro Ala Lys Tyr Asp 
                245                 250                 255     


Asp Ile Lys Lys Val Val Lys Gln Ala Ser Glu Gly Pro Leu Lys Gly 
            260                 265                 270         


Ile Leu Gly Tyr Thr Glu His Gln Val Val Ser Ser Asp Phe Asn Ser 
        275                 280                 285             


Asp Thr His Ser Ser Thr Phe Asp Ala Gly Ala Gly Ile Ala Leu Asn 
    290                 295                 300                 


Asp His Phe Val Lys Leu Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr 
305                 310                 315                 320 


Ser Asn Arg Val Val Asp Leu Met Ala His Met Ala Ser Lys Glu 
                325                 330                 335 


<210>  38
<211>  260
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Glyceraldehyde-3 phosphate dehydrogenase Variant 5

<400>  38

Met Glu Glu Met Arg Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala Gly 
1               5                   10                  15      


Ala Glu Tyr Val Val Glu Ser Thr Gly Val Phe Thr Thr Met Glu Lys 
            20                  25                  30          


Ala Gly Ala His Leu Gln Gly Gly Ala Lys Arg Val Ile Ile Ser Ala 
        35                  40                  45              


Pro Ser Ala Asp Ala Pro Met Phe Val Met Gly Val Asn His Glu Lys 
    50                  55                  60                  


Tyr Asp Asn Ser Leu Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn 
65                  70                  75                  80  


Cys Leu Ala Pro Leu Ala Lys Val Ile His Asp Asn Phe Gly Ile Val 
                85                  90                  95      


Glu Gly Leu Met Thr Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr 
            100                 105                 110         


Val Asp Gly Pro Ser Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala Leu 
        115                 120                 125             


Gln Asn Ile Ile Pro Ala Ser Thr Gly Ala Ala Lys Ala Val Gly Lys 
    130                 135                 140                 


Val Ile Pro Glu Leu Asn Gly Lys Leu Thr Gly Met Ala Phe Arg Val 
145                 150                 155                 160 


Pro Thr Ala Asn Val Ser Val Val Asp Leu Thr Cys Arg Leu Glu Lys 
                165                 170                 175     


Pro Ala Lys Tyr Asp Asp Ile Lys Lys Val Val Lys Gln Ala Ser Glu 
            180                 185                 190         


Gly Pro Leu Lys Gly Ile Leu Gly Tyr Thr Glu His Gln Val Val Ser 
        195                 200                 205             


Ser Asp Phe Asn Ser Asp Thr His Ser Ser Thr Phe Asp Ala Gly Ala 
    210                 215                 220                 


Gly Ile Ala Leu Asn Asp His Phe Val Lys Leu Ile Ser Trp Tyr Asp 
225                 230                 235                 240 


Asn Glu Phe Gly Tyr Ser Asn Arg Val Val Asp Leu Met Ala His Met 
                245                 250                 255     


Ala Ser Lys Glu 
            260 


<210>  39
<211>  293
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Glyceraldehyde-3 phosphate dehydrogenase Variant 6

<400>  39

Met Val Tyr Met Phe Gln Tyr Asp Ser Thr His Gly Lys Phe His Gly 
1               5                   10                  15      


Thr Val Lys Ala Glu Asn Gly Lys Leu Val Ile Asn Gly Asn Pro Ile 
            20                  25                  30          


Thr Ile Phe Gln Glu Arg Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala 
        35                  40                  45              


Gly Ala Glu Tyr Val Val Glu Ser Thr Gly Val Phe Thr Thr Met Glu 
    50                  55                  60                  


Lys Ala Gly Ala His Leu Gln Gly Gly Ala Lys Arg Val Ile Ile Ser 
65                  70                  75                  80  


Ala Pro Ser Ala Asp Ala Pro Met Phe Val Met Gly Val Asn His Glu 
                85                  90                  95      


Lys Tyr Asp Asn Ser Leu Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr 
            100                 105                 110         


Asn Cys Leu Ala Pro Leu Ala Lys Val Ile His Asp Asn Phe Gly Ile 
        115                 120                 125             


Val Glu Gly Leu Met Thr Thr Val His Ala Ile Thr Ala Thr Gln Lys 
    130                 135                 140                 


Thr Val Asp Gly Pro Ser Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala 
145                 150                 155                 160 


Leu Gln Asn Ile Ile Pro Ala Ser Thr Gly Ala Ala Lys Ala Val Gly 
                165                 170                 175     


Lys Val Ile Pro Glu Leu Asn Gly Lys Leu Thr Gly Met Ala Phe Arg 
            180                 185                 190         


Val Pro Thr Ala Asn Val Ser Val Val Asp Leu Thr Cys Arg Leu Glu 
        195                 200                 205             


Lys Pro Ala Lys Tyr Asp Asp Ile Lys Lys Val Val Lys Gln Ala Ser 
    210                 215                 220                 


Glu Gly Pro Leu Lys Gly Ile Leu Gly Tyr Thr Glu His Gln Val Val 
225                 230                 235                 240 


Ser Ser Asp Phe Asn Ser Asp Thr His Ser Ser Thr Phe Asp Ala Gly 
                245                 250                 255     


Ala Gly Ile Ala Leu Asn Asp His Phe Val Lys Leu Ile Ser Trp Tyr 
            260                 265                 270         


Asp Asn Glu Phe Gly Tyr Ser Asn Arg Val Val Asp Leu Met Ala His 
        275                 280                 285             


Met Ala Ser Lys Glu 
    290             


<210>  40
<211>  1790
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Fibronectin Type III Domain Containing  protein 1 Variant 2

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  40

Xaa Pro Arg His Val Lys Leu Leu Ser Thr Lys Met Gly Leu Lys Val 
1               5                   10                  15      


Thr Trp Asp Pro Pro Lys Asp Ala Thr Ser Arg Pro Val Glu His Tyr 
            20                  25                  30          


Asn Ile Ala Tyr Gly Lys Ser Leu Lys Ser Leu Lys Tyr Ile Lys Val 
        35                  40                  45              


Asn Ala Glu Thr Tyr Ser Phe Leu Ile Glu Asp Val Glu Pro Gly Val 
    50                  55                  60                  


Val Tyr Phe Val Leu Leu Thr Ala Glu Asn His Ser Gly Val Ser Arg 
65                  70                  75                  80  


Pro Val Tyr Arg Ala Glu Ser Pro Pro Gly Gly Glu Trp Ile Glu Ile 
                85                  90                  95      


Asp Gly Phe Pro Ile Lys Gly Pro Gly Pro Phe Asn Glu Thr Val Thr 
            100                 105                 110         


Glu Lys Glu Val Pro Asn Lys Pro Leu Arg Val Arg Val Arg Ser Ser 
        115                 120                 125             


Asp Asp Arg Leu Ser Val Ala Trp Lys Ala Pro Arg Leu Ser Gly Ala 
    130                 135                 140                 


Lys Ser Pro Arg Arg Ser Arg Gly Phe Leu Leu Gly Tyr Gly Glu Ser 
145                 150                 155                 160 


Gly Arg Lys Met Asn Tyr Val Pro Leu Thr Arg Asp Glu Arg Thr His 
                165                 170                 175     


Glu Ile Lys Lys Leu Ala Ser Glu Ser Val Tyr Val Val Ser Leu Gln 
            180                 185                 190         


Ser Met Asn Ser Gln Gly Arg Ser Gln Pro Val Tyr Arg Ala Ala Leu 
        195                 200                 205             


Thr Lys Arg Lys Ile Ser Glu Glu Asp Glu Leu Asp Val Pro Asp Asp 
    210                 215                 220                 


Ile Ser Val Arg Val Met Ser Ser Gln Ser Val Leu Val Ser Trp Val 
225                 230                 235                 240 


Asp Pro Val Leu Glu Lys Gln Lys Lys Val Val Ala Ser Arg Gln Tyr 
                245                 250                 255     


Thr Val Arg Tyr Arg Glu Lys Gly Glu Leu Ala Arg Trp Asp Tyr Lys 
            260                 265                 270         


Gln Ile Ala Asn Arg Arg Val Leu Ile Glu Asn Leu Ile Pro Asp Thr 
        275                 280                 285             


Val Tyr Glu Phe Ala Val Arg Ile Ser Gln Gly Glu Arg Asp Gly Lys 
    290                 295                 300                 


Trp Ser Thr Ser Val Phe Gln Arg Thr Pro Glu Ser Ala Pro Thr Thr 
305                 310                 315                 320 


Ala Pro Glu Asn Leu Asn Val Trp Pro Val Asn Gly Lys Pro Thr Val 
                325                 330                 335     


Val Ala Ala Ser Trp Asp Ala Leu Pro Glu Thr Glu Gly Lys Val Lys 
            340                 345                 350         


Ala Ser Lys Ala Asp Val Glu Gln Asn Thr Glu Asp Asn Gly Lys Pro 
        355                 360                 365             


Glu Lys Pro Glu Pro Ser Ser Pro Ser Pro Arg Ala Pro Ala Ser Ser 
    370                 375                 380                 


Gln His Pro Ser Val Pro Ala Ser Pro Gln Gly Arg Asn Ala Lys Asp 
385                 390                 395                 400 


Leu Leu Leu Asp Leu Lys Asn Lys Ile Leu Ala Asn Gly Gly Ala Pro 
                405                 410                 415     


Arg Lys Pro Gln Leu Arg Ala Lys Lys Ala Glu Glu Leu Asp Leu Gln 
            420                 425                 430         


Ser Thr Glu Ile Thr Gly Glu Glu Glu Leu Gly Ser Arg Glu Asp Ser 
        435                 440                 445             


Pro Met Ser Pro Ser Asp Thr Gln Asp Gln Lys Arg Thr Leu Arg Pro 
    450                 455                 460                 


Pro Ser Arg His Gly His Ser Val Val Ala Pro Gly Arg Thr Ala Val 
465                 470                 475                 480 


Arg Ala Arg Met Pro Ala Leu Pro Arg Arg Glu Gly Val Asp Lys Pro 
                485                 490                 495     


Gly Phe Ser Leu Ala Thr Gln Pro Arg Pro Gly Ala Pro Pro Ser Ala 
            500                 505                 510         


Ser Ala Ser Pro Ala His His Ala Ser Thr Gln Gly Thr Ser His Arg 
        515                 520                 525             


Pro Ser Leu Pro Ala Ser Leu Asn Asp Asn Asp Leu Val Asp Ser Asp 
    530                 535                 540                 


Glu Asp Glu Arg Ala Val Gly Ser Leu His Pro Lys Gly Ala Phe Ala 
545                 550                 555                 560 


Gln Pro Arg Pro Ala Leu Ser Pro Ser Arg Gln Ser Pro Ser Ser Val 
                565                 570                 575     


Leu Arg Asp Arg Ser Ser Val His Pro Gly Ala Lys Pro Ala Ser Pro 
            580                 585                 590         


Ala Arg Arg Thr Pro His Ser Gly Ala Ala Glu Glu Asp Ser Ser Ala 
        595                 600                 605             


Ser Ala Pro Pro Ser Arg Leu Ser Pro Pro His Gly Gly Ser Ser Arg 
    610                 615                 620                 


Leu Leu Pro Thr Gln Pro His Leu Ser Ser Pro Leu Ser Lys Gly Gly 
625                 630                 635                 640 


Lys Asp Gly Glu Asp Ala Pro Ala Thr Asn Ser Asn Ala Pro Ser Arg 
                645                 650                 655     


Ser Thr Met Ser Ser Ser Val Ser Ser His Leu Ser Ser Arg Thr Gln 
            660                 665                 670         


Val Ser Glu Gly Ala Glu Ala Ser Asp Gly Glu Ser His Gly Asp Gly 
        675                 680                 685             


Asp Arg Glu Asp Gly Gly Arg Gln Ala Glu Ala Thr Ala Gln Thr Leu 
    690                 695                 700                 


Arg Ala Arg Pro Ala Ser Gly His Phe His Leu Leu Arg His Lys Pro 
705                 710                 715                 720 


Phe Ala Ala Asn Gly Arg Ser Pro Ser Arg Phe Ser Ile Gly Arg Gly 
                725                 730                 735     


Pro Arg Leu Gln Pro Ser Ser Ser Pro Gln Ser Thr Val Pro Ser Arg 
            740                 745                 750         


Ala His Pro Arg Val Pro Ser His Ser Asp Ser His Pro Lys Leu Ser 
        755                 760                 765             


Ser Gly Ile His Gly Asp Glu Glu Asp Glu Lys Pro Leu Pro Ala Thr 
    770                 775                 780                 


Val Val Asn Asp His Val Pro Ser Ser Ser Arg Gln Pro Ile Ser Arg 
785                 790                 795                 800 


Gly Trp Glu Asp Leu Arg Arg Ser Pro Gln Arg Gly Ala Ser Leu His 
                805                 810                 815     


Arg Lys Glu Pro Ile Pro Glu Asn Pro Lys Ser Thr Gly Ala Asp Thr 
            820                 825                 830         


His Pro Gln Gly Lys Tyr Ser Ser Leu Ala Ser Lys Ala Gln Asp Val 
        835                 840                 845             


Gln Gln Ser Thr Asp Ala Asp Thr Glu Gly His Ser Pro Lys Ala Gln 
    850                 855                 860                 


Pro Gly Ser Thr Asp Arg His Ala Ser Pro Ala Arg Pro Pro Ala Ala 
865                 870                 875                 880 


Arg Ser Gln Gln His Pro Ser Val Pro Arg Arg Met Thr Pro Gly Arg 
                885                 890                 895     


Ala Pro Gln Gln Gln Pro Pro Pro Pro Val Ala Thr Ser Gln His His 
            900                 905                 910         


Pro Gly Pro Gln Ser Arg Asp Ala Gly Arg Ser Pro Ser Gln Pro Arg 
        915                 920                 925             


Leu Ser Leu Thr Gln Ala Gly Arg Pro Arg Pro Thr Ser Gln Gly Arg 
    930                 935                 940                 


Ser His Ser Ser Ser Asp Pro Tyr Thr Ala Ser Ser Arg Gly Met Leu 
945                 950                 955                 960 


Pro Thr Ala Leu Gln Asn Gln Asp Glu Asp Ala Gln Gly Ser Tyr Asp 
                965                 970                 975     


Asp Asp Ser Thr Glu Val Glu Ala Gln Asp Val Arg Ala Pro Ala His 
            980                 985                 990         


Ala Ala Arg Ala Lys Glu Ala Ala  Ala Ser Leu Pro Lys  His Gln Gln 
        995                 1000                 1005             


Val Glu  Ser Pro Thr Gly Ala  Gly Ala Gly Gly Asp  His Arg Ser 
    1010                 1015                 1020             


Gln Arg  Gly His Ala Ala Ser  Pro Ala Arg Pro Ser  Arg Pro Gly 
    1025                 1030                 1035             


Gly Pro  Gln Ser Arg Ala Arg  Val Pro Ser Arg Ala  Ala Pro Gly 
    1040                 1045                 1050             


Lys Ser  Glu Pro Pro Ser Lys  Arg Pro Leu Ser Ser  Lys Ser Gln 
    1055                 1060                 1065             


Gln Ser  Val Ser Ala Glu Asp  Asp Glu Glu Glu Asp  Ala Gly Phe 
    1070                 1075                 1080             


Phe Lys  Gly Gly Lys Glu Asp  Leu Leu Ser Ser Ser  Val Pro Lys 
    1085                 1090                 1095             


Trp Pro  Ser Ser Ser Thr Pro  Arg Gly Gly Lys Asp  Ala Asp Gly 
    1100                 1105                 1110             


Ser Leu  Ala Lys Glu Glu Arg  Glu Pro Ala Ile Ala  Leu Ala Pro 
    1115                 1120                 1125             


Arg Gly  Gly Ser Leu Ala Pro  Val Lys Arg Pro Leu  Pro Pro Pro 
    1130                 1135                 1140             


Pro Gly  Ser Ser Pro Arg Ala  Ser His Val Pro Ser  Arg Leu Pro 
    1145                 1150                 1155             


Pro Arg  Ser Ala Ala Thr Val  Ser Pro Val Ala Gly  Thr His Pro 
    1160                 1165                 1170             


Trp Pro  Gln Tyr Thr Thr Arg  Ala Pro Pro Gly His  Phe Ser Thr 
    1175                 1180                 1185             


Thr Pro  Met Leu Ser Leu Arg  Gln Arg Met Met His  Ala Arg Phe 
    1190                 1195                 1200             


Arg Asn  Pro Leu Ser Arg Gln  Pro Ala Arg Pro Ser  Tyr Arg Gln 
    1205                 1210                 1215             


Gly Tyr  Asn Gly Arg Pro Asn  Val Glu Gly Lys Val  Leu Pro Gly 
    1220                 1225                 1230             


Ser Asn  Gly Lys Pro Asn Gly  Gln Arg Ile Ile Asn  Gly Pro Gln 
    1235                 1240                 1245             


Gly Thr  Lys Trp Val Val Asp  Leu Asp Arg Gly Leu  Val Leu Asn 
    1250                 1255                 1260             


Ala Glu  Gly Arg Tyr Leu Gln  Asp Ser His Gly Asn  Pro Leu Arg 
    1265                 1270                 1275             


Ile Lys  Leu Gly Gly Asp Gly  Arg Thr Ile Val Asp  Leu Glu Gly 
    1280                 1285                 1290             


Thr Pro  Val Val Ser Pro Asp  Gly Leu Pro Leu Phe  Gly Gln Gly 
    1295                 1300                 1305             


Arg His  Gly Thr Pro Leu Ala  Asn Ala Gln Asp Lys  Pro Ile Leu 
    1310                 1315                 1320             


Ser Leu  Gly Gly Lys Pro Leu  Val Gly Leu Glu Val  Ile Lys Lys 
    1325                 1330                 1335             


Thr Thr  His Pro Pro Thr Thr  Thr Met Gln Pro Thr  Thr Thr Thr 
    1340                 1345                 1350             


Thr Pro  Leu Pro Thr Thr Thr  Thr Pro Arg Pro Thr  Thr Ala Thr 
    1355                 1360                 1365             


Thr Arg  Arg Thr Thr Thr Thr  Arg Arg Thr Thr Thr  Arg Arg Pro 
    1370                 1375                 1380             


Thr Thr  Thr Val Arg Thr Thr  Thr Arg Thr Thr Thr  Thr Thr Thr 
    1385                 1390                 1395             


Pro Thr  Pro Thr Thr Pro Ile  Pro Thr Cys Pro Pro  Gly Thr Leu 
    1400                 1405                 1410             


Glu Arg  His Asp Asp Asp Gly  Asn Leu Ile Met Ser  Ser Asn Gly 
    1415                 1420                 1425             


Ile Pro  Glu Cys Tyr Ala Glu  Glu Asp Glu Phe Ser  Gly Leu Glu 
    1430                 1435                 1440             


Thr Asp  Thr Ala Val Pro Thr  Glu Glu Ala Tyr Val  Ile Tyr Asp 
    1445                 1450                 1455             


Glu Asp  Tyr Glu Phe Glu Thr  Ser Arg Pro Pro Thr  Thr Thr Glu 
    1460                 1465                 1470             


Pro Ser  Thr Thr Ala Thr Thr  Pro Arg Val Ile Pro  Glu Glu Gly 
    1475                 1480                 1485             


Ala Ile  Ser Ser Phe Pro Glu  Glu Glu Phe Asp Leu  Ala Gly Arg 
    1490                 1495                 1500             


Lys Arg  Phe Val Ala Pro Tyr  Val Thr Tyr Leu Asn  Lys Asp Pro 
    1505                 1510                 1515             


Ser Ala  Pro Cys Ser Leu Thr  Asp Ala Leu Asp His  Phe Gln Val 
    1520                 1525                 1530             


Asp Ser  Leu Asp Glu Ile Ile  Pro Asn Asp Leu Lys  Lys Ser Asp 
    1535                 1540                 1545             


Leu Pro  Pro Gln His Ala Pro  Arg Asn Ile Thr Val  Val Ala Val 
    1550                 1555                 1560             


Glu Gly  Cys His Ser Phe Val  Ile Val Asp Trp Asp  Lys Ala Thr 
    1565                 1570                 1575             


Pro Gly  Asp Val Val Thr Gly  Tyr Leu Val Tyr Ser  Ala Ser Tyr 
    1580                 1585                 1590             


Glu Asp  Phe Ile Arg Asn Lys  Trp Ser Thr Gln Ala  Ser Ser Val 
    1595                 1600                 1605             


Thr His  Leu Pro Ile Glu Asn  Leu Lys Pro Asn Thr  Arg Tyr Tyr 
    1610                 1615                 1620             


Phe Lys  Val Gln Ala Gln Asn  Pro His Gly Tyr Gly  Pro Ile Ser 
    1625                 1630                 1635             


Pro Ser  Val Ser Phe Val Thr  Glu Ser Asp Asn Pro  Leu Leu Val 
    1640                 1645                 1650             


Val Arg  Pro Pro Gly Gly Glu  Pro Ile Trp Ile Pro  Phe Ala Phe 
    1655                 1660                 1665             


Lys His  Asp Pro Ser Tyr Thr  Asp Cys His Gly Arg  Gln Tyr Val 
    1670                 1675                 1680             


Lys Arg  Thr Trp Tyr Arg Lys  Phe Val Gly Val Val  Leu Cys Asn 
    1685                 1690                 1695             


Ser Leu  Arg Tyr Lys Ile Tyr  Leu Ser Asp Asn Leu  Lys Asp Thr 
    1700                 1705                 1710             


Phe Tyr  Ser Ile Gly Asp Ser  Trp Gly Arg Gly Glu  Asp His Cys 
    1715                 1720                 1725             


Gln Phe  Val Asp Ser His Leu  Asp Gly Arg Thr Gly  Pro Gln Ser 
    1730                 1735                 1740             


Tyr Val  Glu Ala Leu Pro Thr  Ile Gln Gly Tyr Tyr  Arg Gln Tyr 
    1745                 1750                 1755             


Arg Gln  Glu Pro Val Arg Phe  Gly Asn Ile Gly Phe  Gly Thr Pro 
    1760                 1765                 1770             


Tyr Tyr  Tyr Val Gly Trp Tyr  Glu Cys Gly Val Ser  Ile Pro Gly 
    1775                 1780                 1785             


Lys Trp  
    1790 


<210>  41
<211>  347
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Eukaryotic initiation factor 4A-I Variant 2

<400>  41

Met Ser Ala Ser Gln Asp Ser Arg Ser Arg Asp Asn Gly Pro Asp Gly 
1               5                   10                  15      


Met Glu Pro Glu Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp 
            20                  25                  30          


Ser Phe Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr 
        35                  40                  45              


Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu 
    50                  55                  60                  


Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr 
65                  70                  75                  80  


Gly Lys Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu 
                85                  90                  95      


Asp Leu Lys Ala Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu 
            100                 105                 110         


Ala Gln Gln Ile Gln Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly 
        115                 120                 125             


Ala Ser Cys His Ala Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val 
    130                 135                 140                 


Gln Lys Leu Gln Met Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly 
145                 150                 155                 160 


Arg Val Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile 
                165                 170                 175     


Lys Met Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe 
            180                 185                 190         


Lys Asp Gln Ile Tyr Asp Ile Phe Gln Lys Leu Asn Ser Asn Thr Gln 
        195                 200                 205             


Val Val Leu Leu Ser Ala Thr Met Pro Ser Asp Val Leu Glu Val Thr 
    210                 215                 220                 


Lys Lys Phe Met Arg Asp Pro Ile Arg Ile Leu Val Lys Lys Glu Glu 
225                 230                 235                 240 


Leu Thr Leu Glu Gly Ile Arg Gln Phe Tyr Ile Asn Val Glu Arg Glu 
                245                 250                 255     


Glu Trp Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr Leu Thr Ile 
            260                 265                 270         


Thr Gln Ala Val Ile Phe Ile Asn Thr Arg Arg Lys Val Asp Trp Leu 
        275                 280                 285             


Thr Glu Lys Met His Ala Arg Asp Phe Thr Val Ser Ala Met His Gly 
    290                 295                 300                 


Asp Met Asp Gln Lys Glu Arg Asp Val Ile Met Arg Glu Phe Arg Ser 
305                 310                 315                 320 


Gly Ser Ser Arg Val Leu Ile Thr Thr Asp Leu Leu Gly Lys Leu Tyr 
                325                 330                 335     


Pro Gln Asn Arg Ser Arg Trp Thr Val Trp Pro 
            340                 345         


<210>  42
<211>  341
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Eukaryotic initiation factor 4A-I Variant 3

<400>  42

Met Ser Ala Ser Gln Asp Ser Arg Ser Arg Asp Asn Gly Pro Asp Gly 
1               5                   10                  15      


Met Glu Pro Glu Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp 
            20                  25                  30          


Ser Phe Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr 
        35                  40                  45              


Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu 
    50                  55                  60                  


Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr 
65                  70                  75                  80  


Gly Lys Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu 
                85                  90                  95      


Asp Leu Lys Ala Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu 
            100                 105                 110         


Ala Gln Gln Ile Gln Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly 
        115                 120                 125             


Ala Ser Cys His Ala Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val 
    130                 135                 140                 


Gln Lys Leu Gln Met Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly 
145                 150                 155                 160 


Arg Val Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile 
                165                 170                 175     


Lys Met Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe 
            180                 185                 190         


Lys Asp Gln Ile Tyr Asp Ile Phe Gln Lys Leu Asn Ser Asn Thr Gln 
        195                 200                 205             


Val Val Leu Leu Ser Ala Thr Met Pro Ser Asp Val Leu Glu Val Thr 
    210                 215                 220                 


Lys Lys Phe Met Arg Asp Pro Ile Arg Ile Leu Val Lys Lys Glu Glu 
225                 230                 235                 240 


Leu Thr Leu Glu Gly Ile Arg Gln Phe Tyr Ile Asn Val Glu Arg Glu 
                245                 250                 255     


Glu Trp Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr Leu Thr Ile 
            260                 265                 270         


Thr Gln Ala Val Ile Phe Ile Asn Thr Arg Arg Lys Val Asp Trp Leu 
        275                 280                 285             


Thr Glu Lys Met His Ala Arg Asp Phe Thr Val Ser Ala Met His Gly 
    290                 295                 300                 


Asp Met Asp Gln Lys Glu Arg Asp Val Ile Met Arg Glu Phe Arg Ser 
305                 310                 315                 320 


Gly Ser Ser Arg Val Leu Ile Thr Thr Asp Leu Leu Asn Arg Ser Arg 
                325                 330                 335     


Trp Thr Val Trp Pro 
            340     


<210>  43
<211>  257
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Eukaryotic initiation factor 4A-I Variant 4

<400>  43

Met Glu Pro Glu Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp 
1               5                   10                  15      


Ser Phe Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr 
            20                  25                  30          


Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu 
        35                  40                  45              


Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr 
    50                  55                  60                  


Gly Lys Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu 
65                  70                  75                  80  


Asp Leu Lys Ala Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu 
                85                  90                  95      


Ala Gln Gln Ile Gln Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly 
            100                 105                 110         


Ala Ser Cys His Ala Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val 
        115                 120                 125             


Gln Lys Leu Gln Met Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly 
    130                 135                 140                 


Arg Val Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile 
145                 150                 155                 160 


Lys Met Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe 
                165                 170                 175     


Lys Asp Gln Ile Tyr Asp Ile Phe Gln Lys Leu Asn Ser Asn Thr Gln 
            180                 185                 190         


Val Val Leu Leu Ser Ala Thr Met Pro Ser Asp Val Leu Glu Val Thr 
        195                 200                 205             


Lys Lys Phe Met Arg Asp Pro Ile Arg Ile Leu Val Lys Lys Glu Glu 
    210                 215                 220                 


Leu Thr Leu Glu Gly Ile Arg Gln Phe Tyr Ile Asn Val Glu Arg Glu 
225                 230                 235                 240 


Glu Trp Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr Leu Thr Ile 
                245                 250                 255     


Thr 
    


<210>  44
<211>  230
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Eukaryotic initiation factor 4A-I Variant 5

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  44

Xaa Val Val Met Ala Leu Gly Asp Tyr Met Gly Ala Ser Cys His Ala 
1               5                   10                  15      


Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val Gln Lys Leu Gln Met 
            20                  25                  30          


Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly Arg Val Phe Asp Met 
        35                  40                  45              


Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile Lys Met Phe Val Leu 
    50                  55                  60                  


Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe Lys Asp Gln Ile Tyr 
65                  70                  75                  80  


Asp Ile Phe Gln Lys Leu Asn Ser Asn Thr Gln Val Val Leu Leu Ser 
                85                  90                  95      


Ala Thr Met Pro Ser Asp Val Leu Glu Val Thr Lys Lys Phe Met Arg 
            100                 105                 110         


Asp Pro Ile Arg Ile Leu Val Lys Lys Glu Glu Leu Thr Leu Glu Gly 
        115                 120                 125             


Ile Arg Gln Phe Tyr Ile Asn Val Glu Arg Glu Glu Trp Lys Leu Asp 
    130                 135                 140                 


Thr Leu Cys Asp Leu Tyr Glu Thr Leu Thr Ile Thr Gln Ala Val Ile 
145                 150                 155                 160 


Phe Ile Asn Thr Arg Arg Lys Val Asp Trp Leu Thr Glu Lys Met His 
                165                 170                 175     


Ala Arg Asp Phe Thr Val Ser Ala Met His Gly Asp Met Asp Gln Lys 
            180                 185                 190         


Glu Arg Asp Val Ile Met Arg Glu Phe Arg Ser Gly Ser Ser Arg Val 
        195                 200                 205             


Leu Ile Thr Thr Asp Leu Leu Gly Lys Leu Tyr Pro Gln Asn Arg Ser 
    210                 215                 220                 


Arg Trp Thr Val Trp Pro 
225                 230 


<210>  45
<211>  300
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Eukaryotic initiation factor 4A-I Variant 6

<400>  45

Met Ser Ala Ser Gln Asp Ser Arg Ser Arg Asp Asn Gly Pro Asp Gly 
1               5                   10                  15      


Met Glu Pro Glu Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp 
            20                  25                  30          


Ser Phe Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr 
        35                  40                  45              


Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu 
    50                  55                  60                  


Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr 
65                  70                  75                  80  


Gly Lys Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu 
                85                  90                  95      


Asp Leu Lys Ala Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu 
            100                 105                 110         


Ala Gln Gln Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly Ala Ser 
        115                 120                 125             


Cys His Ala Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val Gln Lys 
    130                 135                 140                 


Leu Gln Met Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly Arg Val 
145                 150                 155                 160 


Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile Lys Met 
                165                 170                 175     


Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe Lys Asp 
            180                 185                 190         


Gln Ile Tyr Asp Ile Phe Gln Lys Leu Asn Ser Asn Thr Gln Val Val 
        195                 200                 205             


Leu Leu Ser Ala Thr Met Pro Ser Asp Val Leu Glu Val Thr Lys Lys 
    210                 215                 220                 


Phe Met Arg Asp Pro Ile Arg Ile Leu Val Lys Lys Glu Glu Leu Thr 
225                 230                 235                 240 


Leu Glu Gly Ile Arg Gln Phe Tyr Ile Asn Val Glu Arg Glu Glu Trp 
                245                 250                 255     


Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr Leu Thr Ile Thr Gln 
            260                 265                 270         


Ala Val Ile Phe Ile Asn Thr Arg Arg Lys Val Asp Trp Leu Thr Glu 
        275                 280                 285             


Lys Met His Ala Arg Asp Phe Thr Val Ser Ala Met 
    290                 295                 300 


<210>  46
<211>  271
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Eukaryotic initiation factor 4A-I Variant 7

<400>  46

Met Ser Ala Ser Gln Asp Ser Arg Ser Arg Asp Asn Gly Pro Asp Gly 
1               5                   10                  15      


Met Glu Pro Glu Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp 
            20                  25                  30          


Ser Phe Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr 
        35                  40                  45              


Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu 
    50                  55                  60                  


Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr 
65                  70                  75                  80  


Gly Lys Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu 
                85                  90                  95      


Asp Leu Lys Ala Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu 
            100                 105                 110         


Ala Gln Gln Ile Gln Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly 
        115                 120                 125             


Ala Ser Cys His Ala Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val 
    130                 135                 140                 


Gln Lys Leu Gln Met Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly 
145                 150                 155                 160 


Arg Val Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile 
                165                 170                 175     


Lys Met Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe 
            180                 185                 190         


Lys Asp Gln Ile Tyr Asp Ile Phe Gln Lys Leu Asn Ser Asn Thr Gln 
        195                 200                 205             


Glu Glu Leu Thr Leu Glu Gly Ile Arg Gln Phe Tyr Ile Asn Val Glu 
    210                 215                 220                 


Arg Glu Glu Trp Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr Leu 
225                 230                 235                 240 


Thr Ile Thr Gln Ala Val Ile Phe Ile Asn Thr Arg Arg Lys Val Asp 
                245                 250                 255     


Trp Leu Thr Glu Lys Met His Ala Arg Asp Phe Thr Val Ser Ala 
            260                 265                 270     


<210>  47
<211>  85
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Eukaryotic initiation factor 4A-I Variant 7

<400>  47

Met Glu Pro Glu Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp 
1               5                   10                  15      


Ser Phe Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr 
            20                  25                  30          


Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu 
        35                  40                  45              


Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr 
    50                  55                  60                  


Gly Lys Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu 
65                  70                  75                  80  


Asp Leu Lys Ala Thr 
                85  


<210>  48
<211>  214
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Eukaryotic initiation factor 4A-I Variant 9

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  48

Xaa Ala Trp Ala His Cys Ala Arg Gly Arg His Arg Pro Arg Pro Pro 
1               5                   10                  15      


Thr Ser Gly Ser Arg Asp Asn Gly Pro Asp Gly Met Glu Pro Glu Gly 
            20                  25                  30          


Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp Ser Phe Asp Asp Met 
        35                  40                  45              


Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr Ala Tyr Gly Phe Glu 
    50                  55                  60                  


Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu Pro Cys Ile Lys Gly 
65                  70                  75                  80  


Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr Gly Lys Thr Ala Thr 
                85                  90                  95      


Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu Asp Leu Lys Ala Thr 
            100                 105                 110         


Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu Ala Gln Gln Ile Gln 
        115                 120                 125             


Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly Ala Ser Cys His Ala 
    130                 135                 140                 


Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val Gln Lys Leu Gln Met 
145                 150                 155                 160 


Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly Arg Val Phe Asp Met 
                165                 170                 175     


Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile Lys Met Phe Val Leu 
            180                 185                 190         


Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe Lys Asp Gln Ile Tyr 
        195                 200                 205             


Asp Ile Phe Gln Lys Leu 
    210                 


<210>  49
<211>  187
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Eukaryotic initiation factor 4A-I Variant 10

<400>  49

Met Ser Ala Ser Gln Asp Ser Arg Asp Asn Gly Pro Asp Gly Met Glu 
1               5                   10                  15      


Pro Glu Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp Ser Phe 
            20                  25                  30          


Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr Ala Tyr 
        35                  40                  45              


Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu Pro Cys 
    50                  55                  60                  


Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr Gly Lys 
65                  70                  75                  80  


Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu Asp Leu 
                85                  90                  95      


Lys Ala Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu Ala Gln 
            100                 105                 110         


Gln Ile Gln Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly Ala Ser 
        115                 120                 125             


Cys His Ala Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val Gln Lys 
    130                 135                 140                 


Leu Gln Met Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly Arg Val 
145                 150                 155                 160 


Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile Lys Met 
                165                 170                 175     


Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser 
            180                 185         


<210>  50
<211>  163
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Eukaryotic initiation factor 4A-I Variant 11

<400>  50

Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr Ala Tyr Gly Phe 
1               5                   10                  15      


Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu Pro Cys Ile Lys 
            20                  25                  30          


Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr Gly Lys Thr Ala 
        35                  40                  45              


Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu Asp Leu Lys Ala 
    50                  55                  60                  


Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu Ala Gln Gln Ile 
65                  70                  75                  80  


Gln Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly Ala Ser Cys His 
                85                  90                  95      


Ala Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val Gln Lys Leu Gln 
            100                 105                 110         


Met Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly Arg Val Phe Asp 
        115                 120                 125             


Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile Lys Met Phe Val 
    130                 135                 140                 


Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe Lys Asp Gln Ile 
145                 150                 155                 160 


Tyr Asp Ile 
            


<210>  51
<211>  134
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Eukaryotic initiation factor 4A-I Variant 12

<400>  51

Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr Ala Tyr Gly Phe 
1               5                   10                  15      


Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu Pro Cys Ile Lys 
            20                  25                  30          


Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr Gly Lys Thr Ala 
        35                  40                  45              


Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu Asp Leu Lys Ala 
    50                  55                  60                  


Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu Ala Gln Gln Ile 
65                  70                  75                  80  


Gln Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly Ala Ser Cys His 
                85                  90                  95      


Ala Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val Gln Lys Leu Gln 
            100                 105                 110         


Met Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly Arg Val Phe Asp 
        115                 120                 125             


Met Leu Asn Arg Arg Tyr 
    130                 


<210>  52
<211>  117
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Eukaryotic initiation factor 4A-I Variant 13

<400>  52

Met Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe Lys 
1               5                   10                  15      


Asp Gln Ile Tyr Asp Ile Phe Gln Lys Leu Asn Ser Asn Thr Gln Val 
            20                  25                  30          


Val Leu Leu Ser Ala Thr Met Pro Ser Asp Val Leu Glu Val Thr Lys 
        35                  40                  45              


Lys Phe Met Arg Asp Pro Ile Arg Ile Leu Val Lys Lys Glu Glu Leu 
    50                  55                  60                  


Thr Leu Glu Gly Ile Arg Gln Phe Tyr Ile Asn Val Glu Arg Glu Glu 
65                  70                  75                  80  


Trp Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr Leu Thr Ile Thr 
                85                  90                  95      


Gln Ala Val Ile Phe Ile Asn Thr Arg Arg Lys Val Asp Trp Leu Thr 
            100                 105                 110         


Glu Lys Met His Ala 
        115         


<210>  53
<211>  85
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Eukaryotic initiation factor 4A-I Variant 14

<400>  53

Met Gly Arg Ser Thr Phe Leu Arg Gly Ser Arg Asp Asn Gly Pro Asp 
1               5                   10                  15      


Gly Met Glu Pro Glu Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val 
            20                  25                  30          


Asp Ser Phe Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile 
        35                  40                  45              


Tyr Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile 
    50                  55                  60                  


Leu Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly 
65                  70                  75                  80  


Thr Gly Lys Thr Ala 
                85  


<210>  54
<211>  334
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  L-lactate dehydrogenase chain B Variant 2

<400>  54

Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu 
1               5                   10                  15      


Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val 
            20                  25                  30          


Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu 
        35                  40                  45              


Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met 
    50                  55                  60                  


Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala 
65                  70                  75                  80  


Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr 
                85                  90                  95      


Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln 
            100                 105                 110         


Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr 
        115                 120                 125             


Ser Pro Asp Cys Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu 
    130                 135                 140                 


Thr Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile 
145                 150                 155                 160 


Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala 
                165                 170                 175     


Glu Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly 
            180                 185                 190         


Glu His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala 
        195                 200                 205             


Gly Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp 
    210                 215                 220                 


Ser Glu Asn Trp Lys Glu Val His Lys Met Val Val Glu Ser Ala Tyr 
225                 230                 235                 240 


Glu Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser 
                245                 250                 255     


Val Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His 
            260                 265                 270         


Pro Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val 
        275                 280                 285             


Phe Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val 
    290                 295                 300                 


Ile Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser 
305                 310                 315                 320 


Ala Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu 
                325                 330                 


<210>  55
<211>  341
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  L-lactate dehydrogenase chain B Variant 3

<220>
<221>  misc_feature
<222>  (335)..(335)
<223>  Xaa can be any naturally occurring amino acid

<400>  55

Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu 
1               5                   10                  15      


Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val 
            20                  25                  30          


Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu 
        35                  40                  45              


Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met 
    50                  55                  60                  


Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala 
65                  70                  75                  80  


Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr 
                85                  90                  95      


Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln 
            100                 105                 110         


Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr 
        115                 120                 125             


Ser Pro Asp Cys Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu 
    130                 135                 140                 


Thr Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile 
145                 150                 155                 160 


Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala 
                165                 170                 175     


Glu Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly 
            180                 185                 190         


Glu His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala 
        195                 200                 205             


Gly Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp 
    210                 215                 220                 


Ser Glu Asn Trp Lys Glu Val His Lys Met Val Val Glu Ser Ala Tyr 
225                 230                 235                 240 


Glu Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser 
                245                 250                 255     


Val Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His 
            260                 265                 270         


Pro Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val 
        275                 280                 285             


Phe Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val 
    290                 295                 300                 


Ile Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser 
305                 310                 315                 320 


Ala Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu Xaa Leu 
                325                 330                 335     


Val Ser Ser Arg Leu 
            340     


<210>  56
<211>  232
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  L-lactate dehydrogenase chain B Variant 4

<400>  56

Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu 
1               5                   10                  15      


Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val 
            20                  25                  30          


Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu 
        35                  40                  45              


Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met 
    50                  55                  60                  


Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala 
65                  70                  75                  80  


Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr 
                85                  90                  95      


Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln 
            100                 105                 110         


Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr 
        115                 120                 125             


Ser Pro Asp Cys Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu 
    130                 135                 140                 


Thr Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile 
145                 150                 155                 160 


Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala 
                165                 170                 175     


Glu Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly 
            180                 185                 190         


Glu His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala 
        195                 200                 205             


Gly Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp 
    210                 215                 220                 


Ser Glu Asn Trp Lys Glu Val His 
225                 230         


<210>  57
<211>  136
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  L-lactate dehydrogenase chain B Variant 5

<400>  57

Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu 
1               5                   10                  15      


Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val 
            20                  25                  30          


Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu 
        35                  40                  45              


Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met 
    50                  55                  60                  


Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala 
65                  70                  75                  80  


Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr 
                85                  90                  95      


Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln 
            100                 105                 110         


Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr 
        115                 120                 125             


Ser Pro Asp Cys Ile Ile Ile Val 
    130                 135     


<210>  58
<211>  102
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  L-lactate dehydrogenase chain B Variant 6

<400>  58

Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu 
1               5                   10                  15      


Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val 
            20                  25                  30          


Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu 
        35                  40                  45              


Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met 
    50                  55                  60                  


Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala 
65                  70                  75                  80  


Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr 
                85                  90                  95      


Ala Gly Val Arg Gln Gln 
            100         


<210>  59
<211>  320
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Nuclear heterogeneous Ribonucleoprotein A1 Variant

<400>  59

Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly 
                245                 250                 255     


Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn 
            260                 265                 270         


Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro 
        275                 280                 285             


Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly 
    290                 295                 300                 


Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
305                 310                 315                 320 


<210>  60
<211>  267
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Nuclear heterogeneous Ribonucleoprotein A1 Variant 3

<400>  60

Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Ser Tyr Asn 
        195                 200                 205             


Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn Phe Gly Pro Met Lys 
    210                 215                 220                 


Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly 
225                 230                 235                 240 


Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly Tyr Gly Gly Ser Ser 
                245                 250                 255     


Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
            260                 265         


<210>  61
<211>  307
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Nuclear heterogeneous Ribonucleoprotein A1 Variant 4

<400>  61

Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Ile Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn 
225                 230                 235                 240 


Phe Gly Gly Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln 
                245                 250                 255     


Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser 
            260                 265                 270         


Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn 
        275                 280                 285             


Gln Gly Gly Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly 
    290                 295                 300                 


Arg Arg Phe 
305         


<210>  62
<211>  191
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Nuclear heterogeneous Ribonucleoprotein A1 Variant 5

<400>  62

Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys Lys 
1               5                   10                  15      


Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp Lys 
            20                  25                  30          


Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu Val 
        35                  40                  45              


Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser Gln 
    50                  55                  60                  


Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly Gly 
65                  70                  75                  80  


Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly Arg 
                85                  90                  95      


Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser Gly 
            100                 105                 110         


Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly Gly 
        115                 120                 125             


Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn Phe 
    130                 135                 140                 


Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro Tyr 
145                 150                 155                 160 


Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly Tyr 
                165                 170                 175     


Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
            180                 185                 190     


<210>  63
<211>  231
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Nuclear heterogeneous Ribonucleoprotein A1 Variant 7

<400>  63

Met Arg Asp Ser Leu Leu Val Ala Lys Phe Leu Gly Thr Gln Asp Leu 
1               5                   10                  15      


Cys Leu Phe Leu Asn Leu Ala Leu Ser Pro Lys Glu Pro Glu Gln Leu 
            20                  25                  30          


Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser 
        35                  40                  45              


Leu Arg Ser His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val 
    50                  55                  60                  


Met Arg Asp Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr 
65                  70                  75                  80  


Tyr Ala Thr Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His 
                85                  90                  95      


Lys Val Asp Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu 
            100                 105                 110         


Asp Ser Gln Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val 
        115                 120                 125             


Gly Gly Ile Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe 
    130                 135                 140                 


Glu Gln Tyr Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly 
145                 150                 155                 160 


Ser Gly Lys Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp 
                165                 170                 175     


Ser Val Asp Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His 
            180                 185                 190         


Asn Cys Glu Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala 
        195                 200                 205             


Ser Ser Ser Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly 
    210                 215                 220                 


Arg Gly Gly Gly Phe Gly Gly 
225                 230     


<210>  64
<211>  113
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Nuclear heterogeneous Ribonucleoprotein A1 Variant 7

<400>  64

Met Arg Asp Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr 
1               5                   10                  15      


Tyr Ala Thr Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His 
            20                  25                  30          


Lys Val Asp Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu 
        35                  40                  45              


Asp Ser Gln Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val 
    50                  55                  60                  


Gly Gly Ile Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe 
65                  70                  75                  80  


Glu Gln Tyr Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly 
                85                  90                  95      


Ser Gly Lys Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp 
            100                 105                 110         


Ser 
    


<210>  65
<211>  156
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Nuclear heterogeneous Ribonucleoprotein A1 Variant 8

<400>  65

Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Phe 
            100                 105                 110         


Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser Gly Asp Gly Tyr 
        115                 120                 125             


Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly Gly Gly Ser Tyr 
    130                 135                 140                 


Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn 
145                 150                 155     


<210>  66
<211>  145
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Nuclear heterogeneous Ribonucleoprotein A1 Variant 9

<400>  66

Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Asp Ser Gln Arg 
        35                  40                  45              


Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile Lys 
    50                  55                  60                  


Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr Gly 
65                  70                  75                  80  


Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys Lys 
                85                  90                  95      


Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp Lys 
            100                 105                 110         


Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu Val 
        115                 120                 125             


Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser Gln 
    130                 135                 140                 


Arg 
145 


<210>  67
<211>  436
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Polycystic kidney disease protein 1-like 1 Variant 2

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  67

Xaa Ser Arg Leu Arg Ala Ser Met Trp Ile Asp Arg Ser Thr Arg Ala 
1               5                   10                  15      


Val Ser Val His Phe Thr Leu Tyr Asn Pro Pro Thr Gln Leu Phe Thr 
            20                  25                  30          


Ser Val Ser Leu Arg Val Glu Ile Leu Pro Thr Gly Ser Leu Val Pro 
        35                  40                  45              


Ser Ser Leu Val Glu Ser Phe Ser Ile Phe Arg Ser Asp Ser Ala Leu 
    50                  55                  60                  


Gln Tyr His Leu Met Leu Pro Gln Leu Val Phe Leu Ala Leu Ser Leu 
65                  70                  75                  80  


Ile His Leu Cys Val Gln Leu Tyr Arg Met Met Asp Lys Gly Val Leu 
                85                  90                  95      


Ser Tyr Trp Arg Lys Pro Arg Asn Trp Leu Glu Leu Ser Val Val Gly 
            100                 105                 110         


Val Ser Leu Thr Tyr Tyr Ala Val Ser Gly His Leu Val Thr Leu Ala 
        115                 120                 125             


Gly Asp Val Thr Asn Gln Phe His Arg Gly Leu Cys Arg Ala Phe Met 
    130                 135                 140                 


Asp Leu Thr Leu Met Ala Ser Trp Asn Gln Arg Ala Arg Trp Leu Arg 
145                 150                 155                 160 


Gly Ile Leu Leu Phe Leu Phe Thr Leu Lys Cys Val Tyr Leu Pro Gly 
                165                 170                 175     


Ile Gln Asn Thr Met Ala Ser Cys Ser Ser Met Met Arg His Ser Leu 
            180                 185                 190         


Pro Ser Ile Phe Val Ala Gly Leu Val Gly Ala Leu Met Leu Ala Ala 
        195                 200                 205             


Leu Ser His Leu His Arg Phe Leu Leu Ser Met Trp Val Leu Pro Pro 
    210                 215                 220                 


Gly Thr Phe Thr Asp Ala Phe Pro Gly Leu Leu Phe His Phe Pro Arg 
225                 230                 235                 240 


Arg Ser Gln Lys Asp Cys Leu Leu Gly Leu Ser Lys Ser Asp Gln Arg 
                245                 250                 255     


Ala Met Ala Cys Tyr Phe Gly Ile Leu Leu Ile Val Ser Ala Thr Leu 
            260                 265                 270         


Cys Phe Gly Met Leu Arg Gly Phe Leu Met Thr Leu Pro Gln Lys Arg 
        275                 280                 285             


Lys Ser Phe Gln Ser Lys Ser Phe Val Arg Leu Lys Asp Val Thr Ala 
    290                 295                 300                 


Tyr Met Trp Glu Lys Val Leu Thr Phe Leu Arg Leu Glu Thr Pro Lys 
305                 310                 315                 320 


Leu Glu Glu Ala Glu Met Val Glu Asn His Asn Tyr Tyr Leu Asp Glu 
                325                 330                 335     


Phe Ala Asn Leu Leu Asp Glu Leu Leu Met Lys Ile Asn Gly Leu Ser 
            340                 345                 350         


Asp Ser Leu Gln Leu Pro Leu Leu Glu Lys Thr Ser Asn Asn Thr Gly 
        355                 360                 365             


Glu Ala Arg Thr Glu Glu Ser Pro Leu Val Asp Ile Ser Ser Tyr Gln 
    370                 375                 380                 


Ala Ala Glu Ser Leu Thr Leu Val Thr Gln Thr Glu Val Gln Trp His 
385                 390                 395                 400 


Asp Leu Gly Ser Leu Gln Pro Pro His Pro Arg Phe Lys Gln Phe Ser 
                405                 410                 415     


Cys Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg Arg Val Pro Leu Cys 
            420                 425                 430         


Leu Ala Asn Phe 
        435     


<210>  68
<211>  164
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Polycystic kidney disease protein 1-like 1 Variant 3

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  68

Xaa Val Gly Gly Pro Glu Asn Pro Tyr Leu Ile Asp Pro Glu Asn Gln 
1               5                   10                  15      


Asn Val Thr Leu Asn Gly Pro Gly Gly Cys Gly Thr Arg Glu Asp Cys 
            20                  25                  30          


Val Leu Ser Leu Gly Arg Thr Arg Thr Glu Ala His Thr Ala Leu Ser 
        35                  40                  45              


Arg Leu Arg Ala Ser Met Trp Ile Asp Arg Ser Thr Arg Ala Val Ser 
    50                  55                  60                  


Val His Phe Thr Leu Tyr Asn Pro Pro Thr Gln Leu Phe Thr Ser Val 
65                  70                  75                  80  


Ser Leu Arg Val Glu Ile Leu Pro Thr Gly Ser Leu Val Pro Ser Ser 
                85                  90                  95      


Leu Val Glu Ser Phe Ser Ile Phe Arg Ser Asp Ser Ala Leu Gln Tyr 
            100                 105                 110         


His Leu Met Leu Pro Gln Leu Val Phe Leu Ala Leu Ser Leu Ile His 
        115                 120                 125             


Leu Cys Val Gln Leu Tyr Arg Met Met Asp Lys Gly Val Leu Ser Tyr 
    130                 135                 140                 


Trp Arg Lys Pro Arg Asn Trp Leu Glu Val Ala Ser Leu Val Ser Phe 
145                 150                 155                 160 


Ser Phe Glu Lys 
                


<210>  69
<211>  646
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heat shock protein cognate 71 kDa  Variant 2

<400>  69

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His 
225                 230                 235                 240 


Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg 
                405                 410                 415     


Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Val Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Asp Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Lys Gln Arg Asp Lys Val Ser Ser Lys Asn Ser Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ala Thr Val Glu Asp Glu Lys Leu Gln Gly 
545                 550                 555                 560 


Lys Ile Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Glu 
                565                 570                 575     


Ile Ile Asn Trp Leu Asp Lys Asn Gln Thr Ala Glu Lys Glu Glu Phe 
            580                 585                 590         


Glu His Gln Gln Lys Glu Leu Glu Lys Val Cys Asn Pro Ile Ile Thr 
        595                 600                 605             


Lys Leu Tyr Gln Ser Ala Gly Gly Met Pro Gly Gly Met Pro Gly Gly 
    610                 615                 620                 


Phe Pro Gly Gly Gly Ala Pro Pro Ser Gly Gly Ala Ser Ser Gly Pro 
625                 630                 635                 640 


Thr Ile Glu Glu Val Asp 
                645     


<210>  70
<211>  646
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heat shock protein cognate 71 kDa  Variant 3

<400>  70

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His 
225                 230                 235                 240 


Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg 
                405                 410                 415     


Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Val Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Asp Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Lys Gln Arg Asp Lys Val Ser Ser Lys Asn Ser Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ala Thr Val Glu Asp Glu Lys Leu Gln Gly 
545                 550                 555                 560 


Lys Ile Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Glu 
                565                 570                 575     


Ile Ile Asn Trp Leu Asp Lys Asn Gln Thr Ala Glu Lys Glu Glu Phe 
            580                 585                 590         


Glu His Gln Gln Lys Glu Leu Glu Lys Val Cys Asn Pro Ile Ile Thr 
        595                 600                 605             


Lys Leu Tyr Gln Ser Ala Gly Gly Met Pro Gly Gly Met Pro Gly Gly 
    610                 615                 620                 


Phe Pro Gly Gly Gly Ala Pro Pro Ser Gly Gly Ala Ser Ser Gly Pro 
625                 630                 635                 640 


Thr Ile Glu Glu Val Asp 
                645     


<210>  71
<211>  493
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heat shock protein cognate 71 kDa Variant 4

<400>  71

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His 
225                 230                 235                 240 


Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg 
                405                 410                 415     


Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Met 
    450                 455                 460                 


Pro Gly Gly Met Pro Gly Gly Phe Pro Gly Gly Gly Ala Pro Pro Ser 
465                 470                 475                 480 


Gly Gly Ala Ser Ser Gly Pro Thr Ile Glu Glu Val Asp 
                485                 490             


<210>  72
<211>  627
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heat shock protein cognate 71 kDa  Variant 5

<400>  72

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Ala Thr Lys Asp Ala Gly Thr 
    130                 135                 140                 


Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro Thr Ala Ala 
145                 150                 155                 160 


Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu Arg Asn Val 
                165                 170                 175     


Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser Ile Leu Thr 
            180                 185                 190         


Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly Asp Thr His 
        195                 200                 205             


Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His Phe Ile Ala 
    210                 215                 220                 


Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn Lys Arg Ala 
225                 230                 235                 240 


Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg Thr Leu Ser 
                245                 250                 255     


Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr Glu Gly Ile 
            260                 265                 270         


Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu Leu Asn Ala 
        275                 280                 285             


Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala Leu Arg Asp 
    290                 295                 300                 


Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu Val Gly Gly 
305                 310                 315                 320 


Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp Phe Phe Asn 
                325                 330                 335     


Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala Val Ala Tyr 
            340                 345                 350         


Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys Ser Glu Asn 
        355                 360                 365             


Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile 
    370                 375                 380                 


Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg Asn Thr Thr 
385                 390                 395                 400 


Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser Asp Asn Gln 
                405                 410                 415     


Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala Met Thr Lys 
            420                 425                 430         


Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile Pro Pro Ala 
        435                 440                 445             


Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn 
    450                 455                 460                 


Gly Ile Leu Asn Val Ser Ala Val Asp Lys Ser Thr Gly Lys Glu Asn 
465                 470                 475                 480 


Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys Glu Asp Ile 
                485                 490                 495     


Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu Asp Glu Lys 
            500                 505                 510         


Gln Arg Asp Lys Val Ser Ser Lys Asn Ser Leu Glu Ser Tyr Ala Phe 
        515                 520                 525             


Asn Met Lys Ala Thr Val Glu Asp Glu Lys Leu Gln Gly Lys Ile Asn 
    530                 535                 540                 


Asp Glu Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Glu Ile Ile Asn 
545                 550                 555                 560 


Trp Leu Asp Lys Asn Gln Thr Ala Glu Lys Glu Glu Phe Glu His Gln 
                565                 570                 575     


Gln Lys Glu Leu Glu Lys Val Cys Asn Pro Ile Ile Thr Lys Leu Tyr 
            580                 585                 590         


Gln Ser Ala Gly Gly Met Pro Gly Gly Met Pro Gly Gly Phe Pro Gly 
        595                 600                 605             


Gly Gly Ala Pro Pro Ser Gly Gly Ala Ser Ser Gly Pro Thr Ile Glu 
    610                 615                 620                 


Glu Val Asp 
625         


<210>  73
<211>  410
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heat shock protein cognate 71 kDa Variant 6

<400>  73

Met Val Asn His Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp 
1               5                   10                  15      


Ile Ser Glu Asn Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu 
            20                  25                  30          


Arg Ala Lys Arg Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile 
        35                  40                  45              


Asp Ser Leu Tyr Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala 
    50                  55                  60                  


Arg Phe Glu Glu Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro 
65                  70                  75                  80  


Val Glu Lys Ala Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His 
                85                  90                  95      


Asp Ile Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys 
            100                 105                 110         


Leu Leu Gln Asp Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn 
        115                 120                 125             


Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu 
    130                 135                 140                 


Ser Gly Asp Lys Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val 
145                 150                 155                 160 


Thr Pro Leu Ser Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val 
                165                 170                 175     


Leu Ile Lys Arg Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe 
            180                 185                 190         


Thr Thr Tyr Ser Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu 
        195                 200                 205             


Gly Glu Arg Ala Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu 
    210                 215                 220                 


Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val 
225                 230                 235                 240 


Thr Phe Asp Ile Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Val Asp 
                245                 250                 255     


Lys Ser Thr Gly Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly 
            260                 265                 270         


Arg Leu Ser Lys Glu Asp Ile Glu Arg Met Val Gln Glu Ala Glu Lys 
        275                 280                 285             


Tyr Lys Ala Glu Asp Glu Lys Gln Arg Asp Lys Val Ser Ser Lys Asn 
    290                 295                 300                 


Ser Leu Glu Ser Tyr Ala Phe Asn Met Lys Ala Thr Val Glu Asp Glu 
305                 310                 315                 320 


Lys Leu Gln Gly Lys Ile Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp 
                325                 330                 335     


Lys Cys Asn Glu Ile Ile Asn Trp Leu Asp Lys Asn Gln Thr Ala Glu 
            340                 345                 350         


Lys Glu Glu Phe Glu His Gln Gln Lys Glu Leu Glu Lys Val Cys Asn 
        355                 360                 365             


Pro Ile Ile Thr Lys Leu Tyr Gln Ser Ala Gly Gly Met Pro Gly Gly 
    370                 375                 380                 


Met Pro Gly Gly Phe Pro Gly Gly Gly Ala Pro Pro Ser Gly Gly Ala 
385                 390                 395                 400 


Ser Ser Gly Pro Thr Ile Glu Glu Val Asp 
                405                 410 


<210>  74
<211>  500
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heat shock protein cognate 71 kDa  Variant 7

<400>  74

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys His Lys Lys Asp Ile Ser Glu Asn Lys Arg 
            100                 105                 110         


Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg Thr Leu 
        115                 120                 125             


Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr Glu Gly 
    130                 135                 140                 


Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu Leu Asn 
145                 150                 155                 160 


Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala Leu Arg 
                165                 170                 175     


Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu Val Gly 
            180                 185                 190         


Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp Phe Phe 
        195                 200                 205             


Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala Val Ala 
    210                 215                 220                 


Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys Ser Glu 
225                 230                 235                 240 


Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly 
                245                 250                 255     


Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg Asn Thr 
            260                 265                 270         


Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser Asp Asn 
        275                 280                 285             


Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala Met Thr 
    290                 295                 300                 


Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile Pro Pro 
305                 310                 315                 320 


Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala 
                325                 330                 335     


Asn Gly Ile Leu Asn Val Ser Ala Val Asp Lys Ser Thr Gly Lys Glu 
            340                 345                 350         


Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys Glu Asp 
        355                 360                 365             


Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu Asp Glu 
    370                 375                 380                 


Lys Gln Arg Asp Lys Val Ser Ser Lys Asn Ser Leu Glu Ser Tyr Ala 
385                 390                 395                 400 


Phe Asn Met Lys Ala Thr Val Glu Asp Glu Lys Leu Gln Gly Lys Ile 
                405                 410                 415     


Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Glu Ile Ile 
            420                 425                 430         


Asn Trp Leu Asp Lys Asn Gln Thr Ala Glu Lys Glu Glu Phe Glu His 
        435                 440                 445             


Gln Gln Lys Glu Leu Glu Lys Val Cys Asn Pro Ile Ile Thr Lys Leu 
    450                 455                 460                 


Tyr Gln Ser Ala Gly Gly Met Pro Gly Gly Met Pro Gly Gly Phe Pro 
465                 470                 475                 480 


Gly Gly Gly Ala Pro Pro Ser Gly Gly Ala Ser Ser Gly Pro Thr Ile 
                485                 490                 495     


Glu Glu Val Asp 
            500 


<210>  75
<211>  312
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heat shock protein cognate 71 kDa  Variant 8

<400>  75

Met Asn Pro Thr Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg 
1               5                   10                  15      


Arg Phe Asp Asp Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe 
            20                  25                  30          


Met Val Val Asn Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys 
        35                  40                  45              


Gly Glu Thr Lys Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu 
    50                  55                  60                  


Thr Lys Met Lys Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr 
65                  70                  75                  80  


Asn Ala Val Val Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln 
                85                  90                  95      


Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile 
            100                 105                 110         


Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys 
        115                 120                 125             


Val Gly Ala Glu Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr 
    130                 135                 140                 


Phe Asp Val Ser Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys 
145                 150                 155                 160 


Ser Thr Ala Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg 
                165                 170                 175     


Met Val Asn His Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp 
            180                 185                 190         


Ile Ser Glu Asn Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu 
        195                 200                 205             


Arg Ala Lys Arg Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile 
    210                 215                 220                 


Asp Ser Leu Tyr Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala 
225                 230                 235                 240 


Arg Phe Glu Glu Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro 
                245                 250                 255     


Val Glu Lys Ala Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His 
            260                 265                 270         


Asp Ile Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys 
        275                 280                 285             


Leu Leu Gln Asp Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn 
    290                 295                 300                 


Pro Asp Glu Ala Val Ala Tyr Gly 
305                 310         


<210>  76
<211>  187
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heat shock protein cognate 71 kDa  Variant 9

<400>  76

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys 
            180                 185         


<210>  77
<211>  223
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heat shock protein cognate 71 kDa  Variant 10

<400>  77

Met Thr Val Leu Ile Lys Arg Asn Thr Thr Ile Pro Thr Lys Gln Thr 
1               5                   10                  15      


Gln Thr Phe Thr Thr Tyr Ser Asp Asn Gln Pro Gly Val Leu Ile Gln 
            20                  25                  30          


Val Tyr Glu Gly Glu Arg Ala Met Thr Lys Asp Asn Asn Leu Leu Gly 
        35                  40                  45              


Lys Phe Glu Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln 
    50                  55                  60                  


Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly Ile Leu Asn Val Ser 
65                  70                  75                  80  


Ala Val Asp Lys Ser Thr Gly Lys Glu Asn Lys Ile Thr Ile Thr Asn 
                85                  90                  95      


Asp Lys Gly Arg Leu Ser Lys Glu Asp Ile Glu Arg Met Val Gln Glu 
            100                 105                 110         


Ala Glu Lys Tyr Lys Ala Glu Asp Glu Lys Gln Arg Asp Lys Val Ser 
        115                 120                 125             


Ser Lys Asn Ser Leu Glu Ser Tyr Ala Phe Asn Met Lys Ala Thr Val 
    130                 135                 140                 


Glu Asp Glu Lys Leu Gln Gly Lys Ile Asn Asp Glu Asp Lys Gln Lys 
145                 150                 155                 160 


Ile Leu Asp Lys Cys Asn Glu Ile Ile Asn Trp Leu Asp Lys Asn Gln 
                165                 170                 175     


Thr Ala Glu Lys Glu Glu Phe Glu His Gln Gln Lys Glu Leu Glu Lys 
            180                 185                 190         


Val Cys Asn Pro Ile Ile Thr Lys Leu Tyr Gln Ser Ala Gly Gly Met 
        195                 200                 205             


Pro Gly Gly Met Pro Gly Gly Phe Pro Gly Gly Gly Ala Pro Pro 
    210                 215                 220             


<210>  78
<211>  150
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heat shock protein cognate 71 kDa  Variant 11

<400>  78

Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile 
1               5                   10                  15      


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
            20                  25                  30          


Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Val Asp Lys Ser Thr Gly 
        35                  40                  45              


Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
    50                  55                  60                  


Glu Asp Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
65                  70                  75                  80  


Asp Glu Lys Gln Arg Asp Lys Val Ser Ser Lys Asn Ser Leu Glu Ser 
                85                  90                  95      


Tyr Ala Phe Asn Met Lys Ala Thr Val Glu Asp Glu Lys Leu Gln Gly 
            100                 105                 110         


Lys Ile Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Glu 
        115                 120                 125             


Ile Ile Asn Trp Leu Asp Lys Asn Gln Thr Ala Glu Lys Glu Glu Phe 
    130                 135                 140                 


Glu His Gln Gln Lys Glu 
145                 150 


<210>  79
<211>  171
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heat shock protein cognate 71 kDa  Variant 12

<400>  79

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg 
                165                 170     


<210>  80
<211>  132
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heat shock protein cognate 71 kDa  Variant 13

<400>  80

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu 
    130         


<210>  81
<211>  183
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heat shock protein cognate 71 kDa  Variant 14

<400>  81

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr 
            180             


<210>  82
<211>  168
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heat shock protein cognate 71 kDa Variant 15

<400>  82

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Glu Thr Lys Ser Phe Tyr Pro Glu Glu Val Ser Ser 
65                  70                  75                  80  


Met Val Leu Thr Lys Met Lys Glu Ile Ala Glu Ala Tyr Leu Gly Lys 
                85                  90                  95      


Thr Val Thr Asn Ala Val Val Thr Val Pro Ala Tyr Phe Asn Asp Ser 
            100                 105                 110         


Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly Leu Asn Val 
        115                 120                 125             


Leu Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu 
    130                 135                 140                 


Asp Lys Lys Val Gly Ala Glu Arg Asn Val Leu Ile Phe Asp Leu Gly 
145                 150                 155                 160 


Gly Gly Thr Phe Asp Val Ser Ile 
                165             


<210>  83
<211>  178
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heat shock protein cognate 71 kDa  Variant 16

<400>  83

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala 
        


<210>  84
<211>  137
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heat shock protein cognate 71 kDa Variant 17

<400>  84

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys 
    130                 135         


<210>  85
<211>  1861
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 2

<400>  85

Met Ala Ser Ser Ala Ser Ser Ser Pro Ala Gly Thr Glu Asp Ser Ala 
1               5                   10                  15      


Pro Ala Gln Gly Gly Phe Gly Ser Asp Tyr Ser Arg Ser Ser Arg Lys 
            20                  25                  30          


Ser Asp Ala Asn Ala Ser Tyr Leu Arg Ala Ala Arg Ala Gly His Leu 
        35                  40                  45              


Glu Lys Ala Leu Asp Tyr Ile Lys Asn Gly Val Asp Ile Asn Ile Cys 
    50                  55                  60                  


Asn Gln Asn Gly Leu Asn Ala Leu His Leu Ala Ser Lys Glu Gly His 
65                  70                  75                  80  


Val Glu Val Val Ser Glu Leu Leu Gln Arg Glu Ala Asn Val Asp Ala 
                85                  90                  95      


Ala Thr Lys Lys Gly Asn Thr Ala Leu His Ile Ala Ser Leu Ala Gly 
            100                 105                 110         


Gln Ala Glu Val Val Lys Val Leu Val Thr Asn Gly Ala Asn Val Asn 
        115                 120                 125             


Ala Gln Ser Gln Asn Gly Phe Thr Pro Leu Tyr Met Ala Ala Gln Glu 
    130                 135                 140                 


Asn His Leu Glu Val Val Lys Phe Leu Leu Asp Asn Gly Ala Ser Gln 
145                 150                 155                 160 


Ser Leu Ala Thr Glu Asp Gly Phe Thr Pro Leu Ala Val Ala Leu Gln 
                165                 170                 175     


Gln Gly His Asp Gln Val Val Ser Leu Leu Leu Glu Asn Asp Thr Lys 
            180                 185                 190         


Gly Lys Val Arg Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp 
        195                 200                 205             


Thr Lys Ala Ala Ala Leu Leu Leu Gln Asn Asp Asn Asn Ala Asp Val 
    210                 215                 220                 


Glu Ser Lys Ser Gly Phe Thr Pro Leu His Ile Ala Ala His Tyr Gly 
225                 230                 235                 240 


Asn Ile Asn Val Ala Thr Leu Leu Leu Asn Arg Ala Ala Ala Val Asp 
                245                 250                 255     


Phe Thr Ala Arg Asn Asp Ile Thr Pro Leu His Val Ala Ser Lys Arg 
            260                 265                 270         


Gly Asn Ala Asn Met Val Lys Leu Leu Leu Asp Arg Gly Ala Lys Ile 
        275                 280                 285             


Asp Ala Lys Thr Arg Asp Gly Leu Thr Pro Leu His Cys Gly Ala Arg 
    290                 295                 300                 


Ser Gly His Glu Gln Val Val Glu Met Leu Leu Asp Arg Ala Ala Pro 
305                 310                 315                 320 


Ile Leu Ser Lys Thr Lys Asn Gly Leu Ser Pro Leu His Met Ala Thr 
                325                 330                 335     


Gln Gly Asp His Leu Asn Cys Val Gln Leu Leu Leu Gln His Asn Val 
            340                 345                 350         


Pro Val Asp Asp Val Thr Asn Asp Tyr Leu Thr Ala Leu His Val Ala 
        355                 360                 365             


Ala His Cys Gly His Tyr Lys Val Ala Lys Val Leu Leu Asp Lys Lys 
    370                 375                 380                 


Ala Asn Pro Asn Ala Lys Ala Leu Asn Gly Phe Thr Pro Leu His Ile 
385                 390                 395                 400 


Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu Leu Leu Lys His 
                405                 410                 415     


Gly Ala Ser Ile Gln Ala Val Thr Glu Ser Gly Leu Thr Pro Ile His 
            420                 425                 430         


Val Ala Ala Phe Met Gly His Val Asn Ile Val Ser Gln Leu Met His 
        435                 440                 445             


His Gly Ala Ser Pro Asn Thr Thr Asn Val Arg Gly Glu Thr Ala Leu 
    450                 455                 460                 


His Met Ala Ala Arg Ser Gly Gln Ala Glu Val Val Arg Tyr Leu Val 
465                 470                 475                 480 


Gln Asp Gly Ala Gln Val Glu Ala Lys Ala Lys Asp Asp Gln Thr Pro 
                485                 490                 495     


Leu His Ile Ser Ala Arg Leu Gly Lys Ala Asp Ile Val Gln Gln Leu 
            500                 505                 510         


Leu Gln Gln Gly Ala Ser Pro Asn Ala Ala Thr Thr Ser Gly Tyr Thr 
        515                 520                 525             


Pro Leu His Leu Ser Ala Arg Glu Gly His Glu Asp Val Ala Ala Phe 
    530                 535                 540                 


Leu Leu Asp His Gly Ala Ser Leu Ser Ile Thr Thr Lys Lys Gly Phe 
545                 550                 555                 560 


Thr Pro Leu His Val Ala Ala Lys Tyr Gly Lys Leu Glu Val Ala Asn 
                565                 570                 575     


Leu Leu Leu Gln Lys Ser Ala Ser Pro Asp Ala Ala Gly Lys Ser Gly 
            580                 585                 590         


Leu Thr Pro Leu His Val Ala Ala His Tyr Asp Asn Gln Lys Val Ala 
        595                 600                 605             


Leu Leu Leu Leu Asp Gln Gly Ala Ser Pro His Ala Ala Ala Lys Asn 
    610                 615                 620                 


Gly Tyr Thr Pro Leu His Ile Ala Ala Lys Lys Asn Gln Met Asp Ile 
625                 630                 635                 640 


Ala Thr Thr Leu Leu Glu Tyr Gly Ala Asp Ala Asn Ala Val Thr Arg 
                645                 650                 655     


Gln Gly Ile Ala Ser Val His Leu Ala Ala Gln Glu Gly His Val Asp 
            660                 665                 670         


Met Val Ser Leu Leu Leu Gly Arg Asn Ala Asn Val Asn Leu Ser Asn 
        675                 680                 685             


Lys Ser Gly Leu Thr Pro Leu His Leu Ala Ala Gln Glu Asp Arg Val 
    690                 695                 700                 


Asn Val Ala Glu Val Leu Val Asn Gln Gly Ala His Val Asp Ala Gln 
705                 710                 715                 720 


Thr Lys Met Gly Tyr Thr Pro Leu His Val Gly Cys His Tyr Gly Asn 
                725                 730                 735     


Ile Lys Ile Val Asn Phe Leu Leu Gln His Ser Ala Lys Val Asn Ala 
            740                 745                 750         


Lys Thr Lys Asn Gly Tyr Thr Pro Leu His Gln Ala Ala Gln Gln Gly 
        755                 760                 765             


His Thr His Ile Ile Asn Val Leu Leu Gln Asn Asn Ala Ser Pro Asn 
    770                 775                 780                 


Glu Leu Thr Val Asn Gly Asn Thr Ala Leu Gly Ile Ala Arg Arg Leu 
785                 790                 795                 800 


Gly Tyr Ile Ser Val Val Asp Thr Leu Lys Ile Val Thr Glu Glu Thr 
                805                 810                 815     


Met Thr Thr Thr Thr Val Thr Glu Lys His Lys Met Asn Val Pro Glu 
            820                 825                 830         


Thr Met Asn Glu Val Leu Asp Met Ser Asp Asp Glu Val Arg Lys Ala 
        835                 840                 845             


Asn Ala Pro Glu Met Leu Ser Asp Gly Glu Tyr Ile Ser Asp Val Glu 
    850                 855                 860                 


Glu Gly Glu Asp Ala Met Thr Gly Asp Thr Asp Lys Tyr Leu Gly Pro 
865                 870                 875                 880 


Gln Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ala Glu Gly Tyr 
                885                 890                 895     


Met Gly Phe Ser Leu Gly Ala Arg Ser Ala Ser Leu Arg Ser Phe Ser 
            900                 905                 910         


Ser Asp Arg Ser Tyr Thr Leu Asn Arg Ser Ser Tyr Ala Arg Asp Ser 
        915                 920                 925             


Met Met Ile Glu Glu Leu Leu Val Pro Ser Lys Glu Gln His Leu Thr 
    930                 935                 940                 


Phe Thr Arg Glu Phe Asp Ser Asp Ser Leu Arg His Tyr Ser Trp Ala 
945                 950                 955                 960 


Ala Asp Thr Leu Asp Asn Val Asn Leu Val Ser Ser Pro Ile His Ser 
                965                 970                 975     


Gly Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg 
            980                 985                 990         


Gly Ser Arg His His Gly Met Arg  Ile Ile Ile Pro Pro  Arg Lys Cys 
        995                 1000                 1005             


Thr Ala  Pro Thr Arg Ile Thr  Cys Arg Leu Val Lys  Arg His Lys 
    1010                 1015                 1020             


Leu Ala  Asn Pro Pro Pro Met  Val Glu Gly Glu Gly  Leu Ala Ser 
    1025                 1030                 1035             


Arg Leu  Val Glu Met Gly Pro  Ala Gly Ala Gln Phe  Leu Gly Pro 
    1040                 1045                 1050             


Val Ile  Val Glu Ile Pro His  Phe Gly Ser Met Arg  Gly Lys Glu 
    1055                 1060                 1065             


Arg Glu  Leu Ile Val Leu Arg  Ser Glu Asn Gly Glu  Thr Trp Lys 
    1070                 1075                 1080             


Glu His  Gln Phe Asp Ser Lys  Asn Glu Asp Leu Thr  Glu Leu Leu 
    1085                 1090                 1095             


Asn Gly  Met Asp Glu Glu Leu  Asp Ser Pro Glu Glu  Leu Gly Lys 
    1100                 1105                 1110             


Lys Arg  Ile Cys Arg Ile Ile  Thr Lys Asp Phe Pro  Gln Tyr Phe 
    1115                 1120                 1125             


Ala Val  Val Ser Arg Ile Lys  Gln Glu Ser Asn Gln  Ile Gly Pro 
    1130                 1135                 1140             


Glu Gly  Gly Ile Leu Ser Ser  Thr Thr Val Pro Leu  Val Gln Ala 
    1145                 1150                 1155             


Ser Phe  Pro Glu Gly Ala Leu  Thr Lys Arg Ile Arg  Val Gly Leu 
    1160                 1165                 1170             


Gln Ala  Gln Pro Val Pro Asp  Glu Ile Val Lys Lys  Ile Leu Gly 
    1175                 1180                 1185             


Asn Lys  Ala Thr Phe Ser Pro  Ile Val Thr Val Glu  Pro Arg Arg 
    1190                 1195                 1200             


Arg Lys  Phe His Lys Pro Ile  Thr Met Thr Ile Pro  Val Pro Pro 
    1205                 1210                 1215             


Pro Ser  Gly Glu Gly Val Ser  Asn Gly Tyr Lys Gly  Asp Thr Thr 
    1220                 1225                 1230             


Pro Asn  Leu Arg Leu Leu Cys  Ser Ile Thr Gly Gly  Thr Ser Pro 
    1235                 1240                 1245             


Ala Gln  Trp Glu Asp Ile Thr  Gly Thr Thr Pro Leu  Thr Phe Ile 
    1250                 1255                 1260             


Lys Asp  Cys Val Ser Phe Thr  Thr Asn Val Ser Ala  Arg Phe Trp 
    1265                 1270                 1275             


Leu Ala  Asp Cys His Gln Val  Leu Glu Thr Val Gly  Leu Ala Thr 
    1280                 1285                 1290             


Gln Leu  Tyr Arg Glu Leu Ile  Cys Val Pro Tyr Met  Ala Lys Phe 
    1295                 1300                 1305             


Val Val  Phe Ala Lys Met Asn  Asp Pro Val Glu Ser  Ser Leu Arg 
    1310                 1315                 1320             


Cys Phe  Cys Met Thr Asp Asp  Lys Val Asp Lys Thr  Leu Glu Gln 
    1325                 1330                 1335             


Gln Glu  Asn Phe Glu Glu Val  Ala Arg Ser Lys Asp  Ile Glu Val 
    1340                 1345                 1350             


Leu Glu  Gly Lys Pro Ile Tyr  Val Asp Cys Tyr Gly  Asn Leu Ala 
    1355                 1360                 1365             


Pro Leu  Thr Lys Gly Gly Gln  Gln Leu Val Phe Asn  Phe Tyr Ser 
    1370                 1375                 1380             


Phe Lys  Glu Asn Arg Leu Pro  Phe Ser Ile Lys Ile  Arg Asp Thr 
    1385                 1390                 1395             


Ser Gln  Glu Pro Cys Gly Arg  Leu Ser Phe Leu Lys  Glu Pro Lys 
    1400                 1405                 1410             


Thr Thr  Lys Gly Leu Pro Gln  Thr Ala Val Cys Asn  Leu Asn Ile 
    1415                 1420                 1425             


Thr Leu  Pro Ala His Lys Lys  Ile Glu Lys Thr Asp  Arg Arg Gln 
    1430                 1435                 1440             


Ser Phe  Ala Ser Leu Ala Leu  Arg Lys Arg Tyr Ser  Tyr Leu Thr 
    1445                 1450                 1455             


Glu Pro  Gly Met Ser Pro Gln  Ser Pro Cys Glu Arg  Thr Asp Ile 
    1460                 1465                 1470             


Arg Met  Ala Ile Val Ala Asp  His Leu Gly Leu Ser  Trp Thr Glu 
    1475                 1480                 1485             


Leu Ala  Arg Glu Leu Asn Phe  Ser Val Asp Glu Ile  Asn Gln Ile 
    1490                 1495                 1500             


Arg Val  Glu Asn Pro Asn Ser  Leu Ile Ser Gln Ser  Phe Met Leu 
    1505                 1510                 1515             


Leu Lys  Lys Trp Val Thr Arg  Asp Gly Lys Asn Ala  Thr Thr Asp 
    1520                 1525                 1530             


Ala Leu  Thr Ser Val Leu Thr  Lys Ile Asn Arg Ile  Asp Ile Val 
    1535                 1540                 1545             


Thr Leu  Leu Glu Gly Pro Ile  Phe Asp Tyr Gly Asn  Ile Ser Gly 
    1550                 1555                 1560             


Thr Arg  Ser Phe Ala Asp Glu  Asn Asn Val Phe His  Asp Pro Val 
    1565                 1570                 1575             


Asp Gly  Tyr Pro Ser Leu Gln  Val Glu Leu Glu Thr  Pro Thr Gly 
    1580                 1585                 1590             


Leu His  Tyr Thr Pro Pro Thr  Pro Phe Gln Gln Asp  Asp Tyr Phe 
    1595                 1600                 1605             


Ser Asp  Ile Ser Ser Ile Glu  Ser Pro Leu Arg Thr  Pro Ser Arg 
    1610                 1615                 1620             


Leu Ser  Asp Gly Leu Val Pro  Ser Gln Gly Asn Ile  Glu His Ser 
    1625                 1630                 1635             


Ala Asp  Gly Pro Pro Val Val  Thr Ala Glu Asp Ala  Ser Leu Glu 
    1640                 1645                 1650             


Asp Ser  Lys Leu Glu Asp Ser  Val Pro Leu Thr Glu  Met Pro Glu 
    1655                 1660                 1665             


Ala Val  Asp Val Asp Glu Ser  Gln Leu Glu Asn Val  Cys Leu Ser 
    1670                 1675                 1680             


Trp Gln  Asn Glu Thr Ser Ser  Gly Asn Leu Glu Ser  Cys Ala Gln 
    1685                 1690                 1695             


Ala Arg  Arg Val Thr Gly Gly  Leu Leu Asp Arg Leu  Asp Asp Ser 
    1700                 1705                 1710             


Pro Asp  Gln Cys Arg Asp Ser  Ile Thr Ser Tyr Leu  Lys Gly Glu 
    1715                 1720                 1725             


Ala Gly  Lys Phe Glu Ala Asn  Gly Ser His Thr Glu  Ile Thr Pro 
    1730                 1735                 1740             


Glu Ala  Lys Thr Lys Ser Tyr  Phe Pro Glu Ser Gln  Asn Asp Val 
    1745                 1750                 1755             


Gly Lys  Gln Ser Thr Lys Glu  Thr Leu Lys Pro Lys  Ile His Gly 
    1760                 1765                 1770             


Ser Gly  His Val Glu Glu Pro  Ala Ser Pro Leu Ala  Ala Tyr Gln 
    1775                 1780                 1785             


Lys Ser  Leu Glu Glu Thr Ser  Lys Leu Ile Ile Glu  Glu Thr Lys 
    1790                 1795                 1800             


Pro Cys  Val Pro Val Ser Met  Lys Lys Met Ser Arg  Thr Ser Pro 
    1805                 1810                 1815             


Ala Asp  Gly Lys Pro Arg Leu  Ser Leu His Glu Glu  Glu Gly Ser 
    1820                 1825                 1830             


Ser Gly  Ser Glu Gln Lys Gln  Gly Glu Gly Phe Lys  Val Lys Thr 
    1835                 1840                 1845             


Lys Lys  Glu Ile Arg His Val  Glu Lys Lys Ser His  Ser 
    1850                 1855                 1860     


<210>  86
<211>  1868
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 3

<400>  86

Met Ser Glu Glu Pro Lys Glu Lys Asn Ala Lys Pro Ala His Arg Lys 
1               5                   10                  15      


Arg Lys Gly Lys Lys Ser Asp Ala Asn Ala Ser Tyr Leu Arg Ala Ala 
            20                  25                  30          


Arg Ala Gly His Leu Glu Lys Ala Leu Asp Tyr Ile Lys Asn Gly Val 
        35                  40                  45              


Asp Ile Asn Ile Cys Asn Gln Asn Gly Leu Asn Ala Leu His Leu Ala 
    50                  55                  60                  


Ser Lys Glu Gly His Val Glu Val Val Ser Glu Leu Leu Gln Arg Glu 
65                  70                  75                  80  


Ala Asn Val Asp Ala Ala Thr Lys Lys Gly Asn Thr Ala Leu His Ile 
                85                  90                  95      


Ala Ser Leu Ala Gly Gln Ala Glu Val Val Lys Val Leu Val Thr Asn 
            100                 105                 110         


Gly Ala Asn Val Asn Ala Gln Ser Gln Asn Gly Phe Thr Pro Leu Tyr 
        115                 120                 125             


Met Ala Ala Gln Glu Asn His Leu Glu Val Val Lys Phe Leu Leu Asp 
    130                 135                 140                 


Asn Gly Ala Ser Gln Ser Leu Ala Thr Glu Asp Gly Phe Thr Pro Leu 
145                 150                 155                 160 


Ala Val Ala Leu Gln Gln Gly His Asp Gln Val Val Ser Leu Leu Leu 
                165                 170                 175     


Glu Asn Asp Thr Lys Gly Lys Val Arg Leu Pro Ala Leu His Ile Ala 
            180                 185                 190         


Ala Arg Lys Asp Asp Thr Lys Ala Ala Ala Leu Leu Leu Gln Asn Asp 
        195                 200                 205             


Asn Asn Ala Asp Val Glu Ser Lys Ser Gly Phe Thr Pro Leu His Ile 
    210                 215                 220                 


Ala Ala His Tyr Gly Asn Ile Asn Val Ala Thr Leu Leu Leu Asn Arg 
225                 230                 235                 240 


Ala Ala Ala Val Asp Phe Thr Ala Arg Asn Asp Ile Thr Pro Leu His 
                245                 250                 255     


Val Ala Ser Lys Arg Gly Asn Ala Asn Met Val Lys Leu Leu Leu Asp 
            260                 265                 270         


Arg Gly Ala Lys Ile Asp Ala Lys Thr Arg Asp Gly Leu Thr Pro Leu 
        275                 280                 285             


His Cys Gly Ala Arg Ser Gly His Glu Gln Val Val Glu Met Leu Leu 
    290                 295                 300                 


Asp Arg Ala Ala Pro Ile Leu Ser Lys Thr Lys Asn Gly Leu Ser Pro 
305                 310                 315                 320 


Leu His Met Ala Thr Gln Gly Asp His Leu Asn Cys Val Gln Leu Leu 
                325                 330                 335     


Leu Gln His Asn Val Pro Val Asp Asp Val Thr Asn Asp Tyr Leu Thr 
            340                 345                 350         


Ala Leu His Val Ala Ala His Cys Gly His Tyr Lys Val Ala Lys Val 
        355                 360                 365             


Leu Leu Asp Lys Lys Ala Asn Pro Asn Ala Lys Ala Leu Asn Gly Phe 
    370                 375                 380                 


Thr Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu 
385                 390                 395                 400 


Leu Leu Leu Lys His Gly Ala Ser Ile Gln Ala Val Thr Glu Ser Gly 
                405                 410                 415     


Leu Thr Pro Ile His Val Ala Ala Phe Met Gly His Val Asn Ile Val 
            420                 425                 430         


Ser Gln Leu Met His His Gly Ala Ser Pro Asn Thr Thr Asn Val Arg 
        435                 440                 445             


Gly Glu Thr Ala Leu His Met Ala Ala Arg Ser Gly Gln Ala Glu Val 
    450                 455                 460                 


Val Arg Tyr Leu Val Gln Asp Gly Ala Gln Val Glu Ala Lys Ala Lys 
465                 470                 475                 480 


Asp Asp Gln Thr Pro Leu His Ile Ser Ala Arg Leu Gly Lys Ala Asp 
                485                 490                 495     


Ile Val Gln Gln Leu Leu Gln Gln Gly Ala Ser Pro Asn Ala Ala Thr 
            500                 505                 510         


Thr Ser Gly Tyr Thr Pro Leu His Leu Ser Ala Arg Glu Gly His Glu 
        515                 520                 525             


Asp Val Ala Ala Phe Leu Leu Asp His Gly Ala Ser Leu Ser Ile Thr 
    530                 535                 540                 


Thr Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala Lys Tyr Gly Lys 
545                 550                 555                 560 


Leu Glu Val Ala Asn Leu Leu Leu Gln Lys Ser Ala Ser Pro Asp Ala 
                565                 570                 575     


Ala Gly Lys Ser Gly Leu Thr Pro Leu His Val Ala Ala His Tyr Asp 
            580                 585                 590         


Asn Gln Lys Val Ala Leu Leu Leu Leu Asp Gln Gly Ala Ser Pro His 
        595                 600                 605             


Ala Ala Ala Lys Asn Gly Tyr Thr Pro Leu His Ile Ala Ala Lys Lys 
    610                 615                 620                 


Asn Gln Met Asp Ile Ala Thr Thr Leu Leu Glu Tyr Gly Ala Asp Ala 
625                 630                 635                 640 


Asn Ala Val Thr Arg Gln Gly Ile Ala Ser Val His Leu Ala Ala Gln 
                645                 650                 655     


Glu Gly His Val Asp Met Val Ser Leu Leu Leu Gly Arg Asn Ala Asn 
            660                 665                 670         


Val Asn Leu Ser Asn Lys Ser Gly Leu Thr Pro Leu His Leu Ala Ala 
        675                 680                 685             


Gln Glu Asp Arg Val Asn Val Ala Glu Val Leu Val Asn Gln Gly Ala 
    690                 695                 700                 


His Val Asp Ala Gln Thr Lys Met Gly Tyr Thr Pro Leu His Val Gly 
705                 710                 715                 720 


Cys His Tyr Gly Asn Ile Lys Ile Val Asn Phe Leu Leu Gln His Ser 
                725                 730                 735     


Ala Lys Val Asn Ala Lys Thr Lys Asn Gly Tyr Thr Pro Leu His Gln 
            740                 745                 750         


Ala Ala Gln Gln Gly His Thr His Ile Ile Asn Val Leu Leu Gln Asn 
        755                 760                 765             


Asn Ala Ser Pro Asn Glu Leu Thr Val Asn Gly Asn Thr Ala Leu Gly 
    770                 775                 780                 


Ile Ala Arg Arg Leu Gly Tyr Ile Ser Val Val Asp Thr Leu Lys Ile 
785                 790                 795                 800 


Val Thr Glu Glu Thr Met Thr Thr Thr Thr Val Thr Glu Lys His Lys 
                805                 810                 815     


Met Asn Val Pro Glu Thr Met Asn Glu Val Leu Asp Met Ser Asp Asp 
            820                 825                 830         


Glu Val Arg Lys Ala Asn Ala Pro Glu Met Leu Ser Asp Gly Glu Tyr 
        835                 840                 845             


Ile Ser Asp Val Glu Glu Gly Asn Arg Cys Thr Trp Tyr Lys Ile Pro 
    850                 855                 860                 


Lys Val Gln Glu Phe Thr Val Lys Ser Glu Asp Ala Met Thr Gly Asp 
865                 870                 875                 880 


Thr Asp Lys Tyr Leu Gly Pro Gln Asp Leu Lys Glu Leu Gly Asp Asp 
                885                 890                 895     


Ser Leu Pro Ala Glu Gly Tyr Met Gly Phe Ser Leu Gly Ala Arg Ser 
            900                 905                 910         


Ala Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser Tyr Thr Leu Asn Arg 
        915                 920                 925             


Ser Ser Tyr Ala Arg Asp Ser Met Met Ile Glu Glu Leu Leu Val Pro 
    930                 935                 940                 


Ser Lys Glu Gln His Leu Thr Phe Thr Arg Glu Phe Asp Ser Asp Ser 
945                 950                 955                 960 


Leu Arg His Tyr Ser Trp Ala Ala Asp Thr Leu Asp Asn Val Asn Leu 
                965                 970                 975     


Val Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp 
            980                 985                 990         


Ala Arg Gly Gly Ser Met Arg Gly  Ser Arg His His Gly  Met Arg Ile 
        995                 1000                 1005             


Ile Ile  Pro Pro Arg Lys Cys  Thr Ala Pro Thr Arg  Ile Thr Cys 
    1010                 1015                 1020             


Arg Leu  Val Lys Arg His Lys  Leu Ala Asn Pro Pro  Pro Met Val 
    1025                 1030                 1035             


Glu Gly  Glu Gly Leu Ala Ser  Arg Leu Val Glu Met  Gly Pro Ala 
    1040                 1045                 1050             


Gly Ala  Gln Phe Leu Gly Pro  Val Ile Val Glu Ile  Pro His Phe 
    1055                 1060                 1065             


Gly Ser  Met Arg Gly Lys Glu  Arg Glu Leu Ile Val  Leu Arg Ser 
    1070                 1075                 1080             


Glu Asn  Gly Glu Thr Trp Lys  Glu His Gln Phe Asp  Ser Lys Asn 
    1085                 1090                 1095             


Glu Asp  Leu Thr Glu Leu Leu  Asn Gly Met Asp Glu  Glu Leu Asp 
    1100                 1105                 1110             


Ser Pro  Glu Glu Leu Gly Lys  Lys Arg Ile Cys Arg  Ile Ile Thr 
    1115                 1120                 1125             


Lys Asp  Phe Pro Gln Tyr Phe  Ala Val Val Ser Arg  Ile Lys Gln 
    1130                 1135                 1140             


Glu Ser  Asn Gln Ile Gly Pro  Glu Gly Gly Ile Leu  Ser Ser Thr 
    1145                 1150                 1155             


Thr Val  Pro Leu Val Gln Ala  Ser Phe Pro Glu Gly  Ala Leu Thr 
    1160                 1165                 1170             


Lys Arg  Ile Arg Val Gly Leu  Gln Ala Gln Pro Val  Pro Asp Glu 
    1175                 1180                 1185             


Ile Val  Lys Lys Ile Leu Gly  Asn Lys Ala Thr Phe  Ser Pro Ile 
    1190                 1195                 1200             


Val Thr  Val Glu Pro Arg Arg  Arg Lys Phe His Lys  Pro Ile Thr 
    1205                 1210                 1215             


Met Thr  Ile Pro Val Pro Pro  Pro Ser Gly Glu Gly  Val Ser Asn 
    1220                 1225                 1230             


Gly Tyr  Lys Gly Asp Thr Thr  Pro Asn Leu Arg Leu  Leu Cys Ser 
    1235                 1240                 1245             


Ile Thr  Gly Gly Thr Ser Pro  Ala Gln Trp Glu Asp  Ile Thr Gly 
    1250                 1255                 1260             


Thr Thr  Pro Leu Thr Phe Ile  Lys Asp Cys Val Ser  Phe Thr Thr 
    1265                 1270                 1275             


Asn Val  Ser Ala Arg Phe Trp  Leu Ala Asp Cys His  Gln Val Leu 
    1280                 1285                 1290             


Glu Thr  Val Gly Leu Ala Thr  Gln Leu Tyr Arg Glu  Leu Ile Cys 
    1295                 1300                 1305             


Val Pro  Tyr Met Ala Lys Phe  Val Val Phe Ala Lys  Met Asn Asp 
    1310                 1315                 1320             


Pro Val  Glu Ser Ser Leu Arg  Cys Phe Cys Met Thr  Asp Asp Lys 
    1325                 1330                 1335             


Val Asp  Lys Thr Leu Glu Gln  Gln Glu Asn Phe Glu  Glu Val Ala 
    1340                 1345                 1350             


Arg Ser  Lys Asp Ile Glu Val  Leu Glu Gly Lys Pro  Ile Tyr Val 
    1355                 1360                 1365             


Asp Cys  Tyr Gly Asn Leu Ala  Pro Leu Thr Lys Gly  Gly Gln Gln 
    1370                 1375                 1380             


Leu Val  Phe Asn Phe Tyr Ser  Phe Lys Glu Asn Arg  Leu Pro Phe 
    1385                 1390                 1395             


Ser Ile  Lys Ile Arg Asp Thr  Ser Gln Glu Pro Cys  Gly Arg Leu 
    1400                 1405                 1410             


Ser Phe  Leu Lys Glu Pro Lys  Thr Thr Lys Gly Leu  Pro Gln Thr 
    1415                 1420                 1425             


Ala Val  Cys Asn Leu Asn Ile  Thr Leu Pro Ala His  Lys Lys Ile 
    1430                 1435                 1440             


Glu Lys  Thr Asp Arg Arg Gln  Ser Phe Ala Ser Leu  Ala Leu Arg 
    1445                 1450                 1455             


Lys Arg  Tyr Ser Tyr Leu Thr  Glu Pro Gly Met Ser  Pro Gln Ser 
    1460                 1465                 1470             


Pro Cys  Glu Arg Thr Asp Ile  Arg Met Ala Ile Val  Ala Asp His 
    1475                 1480                 1485             


Leu Gly  Leu Ser Trp Thr Glu  Leu Ala Arg Glu Leu  Asn Phe Ser 
    1490                 1495                 1500             


Val Asp  Glu Ile Asn Gln Ile  Arg Val Glu Asn Pro  Asn Ser Leu 
    1505                 1510                 1515             


Ile Ser  Gln Ser Phe Met Leu  Leu Lys Lys Trp Val  Thr Arg Asp 
    1520                 1525                 1530             


Gly Lys  Asn Ala Thr Thr Asp  Ala Leu Thr Ser Val  Leu Thr Lys 
    1535                 1540                 1545             


Ile Asn  Arg Ile Asp Ile Val  Thr Leu Leu Glu Gly  Pro Ile Phe 
    1550                 1555                 1560             


Asp Tyr  Gly Asn Ile Ser Gly  Thr Arg Ser Phe Ala  Asp Glu Asn 
    1565                 1570                 1575             


Asn Val  Phe His Asp Pro Val  Asp Gly Tyr Pro Ser  Leu Gln Val 
    1580                 1585                 1590             


Glu Leu  Glu Thr Pro Thr Gly  Leu His Tyr Thr Pro  Pro Thr Pro 
    1595                 1600                 1605             


Phe Gln  Gln Asp Asp Tyr Phe  Ser Asp Ile Ser Ser  Ile Glu Ser 
    1610                 1615                 1620             


Pro Leu  Arg Thr Pro Ser Arg  Leu Ser Asp Gly Leu  Val Pro Ser 
    1625                 1630                 1635             


Gln Gly  Asn Ile Glu His Ser  Ala Asp Gly Pro Pro  Val Val Thr 
    1640                 1645                 1650             


Ala Glu  Asp Ala Ser Leu Glu  Asp Ser Lys Leu Glu  Asp Ser Val 
    1655                 1660                 1665             


Pro Leu  Thr Glu Met Pro Glu  Ala Val Asp Val Asp  Glu Ser Gln 
    1670                 1675                 1680             


Leu Glu  Asn Val Cys Leu Ser  Trp Gln Asn Glu Thr  Ser Ser Gly 
    1685                 1690                 1695             


Asn Leu  Glu Ser Cys Ala Gln  Ala Arg Arg Val Thr  Gly Gly Leu 
    1700                 1705                 1710             


Leu Asp  Arg Leu Asp Asp Ser  Pro Asp Gln Cys Arg  Asp Ser Ile 
    1715                 1720                 1725             


Thr Ser  Tyr Leu Lys Gly Glu  Ala Gly Lys Phe Glu  Ala Asn Gly 
    1730                 1735                 1740             


Ser His  Thr Glu Ile Thr Pro  Glu Ala Lys Thr Lys  Ser Tyr Phe 
    1745                 1750                 1755             


Pro Glu  Ser Gln Asn Asp Val  Gly Lys Gln Ser Thr  Lys Glu Thr 
    1760                 1765                 1770             


Leu Lys  Pro Lys Ile His Gly  Ser Gly His Val Glu  Glu Pro Ala 
    1775                 1780                 1785             


Ser Pro  Leu Ala Ala Tyr Gln  Lys Ser Leu Glu Glu  Thr Ser Lys 
    1790                 1795                 1800             


Leu Ile  Ile Glu Glu Thr Lys  Pro Cys Val Pro Val  Ser Met Lys 
    1805                 1810                 1815             


Lys Met  Ser Arg Thr Ser Pro  Ala Asp Gly Lys Pro  Arg Leu Ser 
    1820                 1825                 1830             


Leu His  Glu Glu Glu Gly Ser  Ser Gly Ser Glu Gln  Lys Gln Gly 
    1835                 1840                 1845             


Glu Gly  Phe Lys Val Lys Thr  Lys Lys Glu Ile Arg  His Val Glu 
    1850                 1855                 1860             


Lys Lys  Ser His Ser 
    1865             


<210>  87
<211>  1001
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 4

<400>  87

Met Ala Leu Pro Gln Ser Glu Asp Ala Met Thr Gly Asp Thr Asp Lys 
1               5                   10                  15      


Tyr Leu Gly Pro Gln Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro 
            20                  25                  30          


Ala Glu Gly Tyr Met Gly Phe Ser Leu Gly Ala Arg Ser Ala Ser Leu 
        35                  40                  45              


Arg Ser Phe Ser Ser Asp Arg Ser Tyr Thr Leu Asn Arg Ser Ser Tyr 
    50                  55                  60                  


Ala Arg Asp Ser Met Met Ile Glu Glu Leu Leu Val Pro Ser Lys Glu 
65                  70                  75                  80  


Gln His Leu Thr Phe Thr Arg Glu Phe Asp Ser Asp Ser Leu Arg His 
                85                  90                  95      


Tyr Ser Trp Ala Ala Asp Thr Leu Asp Asn Val Asn Leu Val Ser Ser 
            100                 105                 110         


Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly 
        115                 120                 125             


Gly Ser Met Arg Gly Ser Arg His His Gly Met Arg Ile Ile Ile Pro 
    130                 135                 140                 


Pro Arg Lys Cys Thr Ala Pro Thr Arg Ile Thr Cys Arg Leu Val Lys 
145                 150                 155                 160 


Arg His Lys Leu Ala Asn Pro Pro Pro Met Val Glu Gly Glu Gly Leu 
                165                 170                 175     


Ala Ser Arg Leu Val Glu Met Gly Pro Ala Gly Ala Gln Phe Leu Gly 
            180                 185                 190         


Pro Val Ile Val Glu Ile Pro His Phe Gly Ser Met Arg Gly Lys Glu 
        195                 200                 205             


Arg Glu Leu Ile Val Leu Arg Ser Glu Asn Gly Glu Thr Trp Lys Glu 
    210                 215                 220                 


His Gln Phe Asp Ser Lys Asn Glu Asp Leu Thr Glu Leu Leu Asn Gly 
225                 230                 235                 240 


Met Asp Glu Glu Leu Asp Ser Pro Glu Glu Leu Gly Lys Lys Arg Ile 
                245                 250                 255     


Cys Arg Ile Ile Thr Lys Asp Phe Pro Gln Tyr Phe Ala Val Val Ser 
            260                 265                 270         


Arg Ile Lys Gln Glu Ser Asn Gln Ile Gly Pro Glu Gly Gly Ile Leu 
        275                 280                 285             


Ser Ser Thr Thr Val Pro Leu Val Gln Ala Ser Phe Pro Glu Gly Ala 
    290                 295                 300                 


Leu Thr Lys Arg Ile Arg Val Gly Leu Gln Ala Gln Pro Val Pro Asp 
305                 310                 315                 320 


Glu Ile Val Lys Lys Ile Leu Gly Asn Lys Ala Thr Phe Ser Pro Ile 
                325                 330                 335     


Val Thr Val Glu Pro Arg Arg Arg Lys Phe His Lys Pro Ile Thr Met 
            340                 345                 350         


Thr Ile Pro Val Pro Pro Pro Ser Gly Glu Gly Val Ser Asn Gly Tyr 
        355                 360                 365             


Lys Gly Asp Thr Thr Pro Asn Leu Arg Leu Leu Cys Ser Ile Thr Gly 
    370                 375                 380                 


Gly Thr Ser Pro Ala Gln Trp Glu Asp Ile Thr Gly Thr Thr Pro Leu 
385                 390                 395                 400 


Thr Phe Ile Lys Asp Cys Val Ser Phe Thr Thr Asn Val Ser Ala Arg 
                405                 410                 415     


Phe Trp Leu Ala Asp Cys His Gln Val Leu Glu Thr Val Gly Leu Ala 
            420                 425                 430         


Thr Gln Leu Tyr Arg Glu Leu Ile Cys Val Pro Tyr Met Ala Lys Phe 
        435                 440                 445             


Val Val Phe Ala Lys Met Asn Asp Pro Val Glu Ser Ser Leu Arg Cys 
    450                 455                 460                 


Phe Cys Met Thr Asp Asp Lys Val Asp Lys Thr Leu Glu Gln Gln Glu 
465                 470                 475                 480 


Asn Phe Glu Glu Val Ala Arg Ser Lys Asp Ile Glu Val Leu Glu Gly 
                485                 490                 495     


Lys Pro Ile Tyr Val Asp Cys Tyr Gly Asn Leu Ala Pro Leu Thr Lys 
            500                 505                 510         


Gly Gly Gln Gln Leu Val Phe Asn Phe Tyr Ser Phe Lys Glu Asn Arg 
        515                 520                 525             


Leu Pro Phe Ser Ile Lys Ile Arg Asp Thr Ser Gln Glu Pro Cys Gly 
    530                 535                 540                 


Arg Leu Ser Phe Leu Lys Glu Pro Lys Thr Thr Lys Gly Leu Pro Gln 
545                 550                 555                 560 


Thr Ala Val Cys Asn Leu Asn Ile Thr Leu Pro Ala His Lys Lys Ile 
                565                 570                 575     


Glu Lys Thr Asp Arg Arg Gln Ser Phe Ala Ser Leu Ala Leu Arg Lys 
            580                 585                 590         


Arg Tyr Ser Tyr Leu Thr Glu Pro Gly Met Ser Pro Gln Ser Pro Cys 
        595                 600                 605             


Glu Arg Thr Asp Ile Arg Met Ala Ile Val Ala Asp His Leu Gly Leu 
    610                 615                 620                 


Ser Trp Thr Glu Leu Ala Arg Glu Leu Asn Phe Ser Val Asp Glu Ile 
625                 630                 635                 640 


Asn Gln Ile Arg Val Glu Asn Pro Asn Ser Leu Ile Ser Gln Ser Phe 
                645                 650                 655     


Met Leu Leu Lys Lys Trp Val Thr Arg Asp Gly Lys Asn Ala Thr Thr 
            660                 665                 670         


Asp Ala Leu Thr Ser Val Leu Thr Lys Ile Asn Arg Ile Asp Ile Val 
        675                 680                 685             


Thr Leu Leu Glu Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser Gly Thr 
    690                 695                 700                 


Arg Ser Phe Ala Asp Glu Asn Asn Val Phe His Asp Pro Val Asp Gly 
705                 710                 715                 720 


Tyr Pro Ser Leu Gln Val Glu Leu Glu Thr Pro Thr Gly Leu His Tyr 
                725                 730                 735     


Thr Pro Pro Thr Pro Phe Gln Gln Asp Asp Tyr Phe Ser Asp Ile Ser 
            740                 745                 750         


Ser Ile Glu Ser Pro Leu Arg Thr Pro Ser Arg Leu Ser Asp Gly Leu 
        755                 760                 765             


Val Pro Ser Gln Gly Asn Ile Glu His Ser Ala Asp Gly Pro Pro Val 
    770                 775                 780                 


Val Thr Ala Glu Asp Ala Ser Leu Glu Asp Ser Lys Leu Glu Asp Ser 
785                 790                 795                 800 


Val Pro Leu Thr Glu Met Pro Glu Ala Val Asp Val Asp Glu Ser Gln 
                805                 810                 815     


Leu Glu Asn Val Cys Leu Ser Trp Gln Asn Glu Thr Ser Ser Gly Asn 
            820                 825                 830         


Leu Glu Ser Cys Ala Gln Ala Arg Arg Val Thr Gly Gly Leu Leu Asp 
        835                 840                 845             


Arg Leu Asp Asp Ser Pro Asp Gln Cys Arg Asp Ser Ile Thr Ser Tyr 
    850                 855                 860                 


Leu Lys Gly Glu Ala Gly Lys Phe Glu Ala Asn Gly Ser His Thr Glu 
865                 870                 875                 880 


Ile Thr Pro Glu Ala Lys Thr Lys Ser Tyr Phe Pro Glu Ser Gln Asn 
                885                 890                 895     


Asp Val Gly Lys Gln Ser Thr Lys Glu Thr Leu Lys Pro Lys Ile His 
            900                 905                 910         


Gly Ser Gly His Val Glu Glu Pro Ala Ser Pro Leu Ala Ala Tyr Gln 
        915                 920                 925             


Lys Ser Leu Glu Glu Thr Ser Lys Leu Ile Ile Glu Glu Thr Lys Pro 
    930                 935                 940                 


Cys Val Pro Val Ser Met Lys Lys Met Ser Arg Thr Ser Pro Ala Asp 
945                 950                 955                 960 


Gly Lys Pro Arg Leu Ser Leu His Glu Glu Glu Gly Ser Ser Gly Ser 
                965                 970                 975     


Glu Gln Lys Gln Gly Glu Gly Phe Lys Val Lys Thr Lys Lys Glu Ile 
            980                 985                 990         


Arg His Val Glu Lys Lys Ser His  Ser 
        995                 1000     


<210>  88
<211>  1643
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 5

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  88

Xaa Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg 
1               5                   10                  15      


Gly Ser Arg His His Gly Met Arg Ile Ile Ile Pro Pro Arg Lys Cys 
            20                  25                  30          


Thr Ala Pro Thr Arg Ile Thr Cys Arg Leu Val Lys Arg His Lys Leu 
        35                  40                  45              


Ala Asn Pro Pro Pro Met Val Glu Gly Glu Gly Leu Ala Ser Arg Leu 
    50                  55                  60                  


Val Glu Met Gly Pro Ala Gly Ala Gln Phe Leu Gly Pro Val Ile Val 
65                  70                  75                  80  


Glu Ile Pro His Phe Gly Ser Met Arg Gly Lys Glu Arg Glu Leu Ile 
                85                  90                  95      


Val Leu Arg Ser Glu Asn Gly Glu Thr Trp Lys Glu His Gln Phe Asp 
            100                 105                 110         


Ser Lys Asn Glu Asp Leu Thr Glu Leu Leu Asn Gly Met Asp Glu Glu 
        115                 120                 125             


Leu Asp Ser Pro Glu Glu Leu Gly Lys Lys Arg Ile Cys Arg Ile Ile 
    130                 135                 140                 


Thr Lys Asp Phe Pro Gln Tyr Phe Ala Val Val Ser Arg Ile Lys Gln 
145                 150                 155                 160 


Glu Ser Asn Gln Ile Gly Pro Glu Gly Gly Ile Leu Ser Ser Thr Thr 
                165                 170                 175     


Val Pro Leu Val Gln Ala Ser Phe Pro Glu Gly Ala Leu Thr Lys Arg 
            180                 185                 190         


Ile Arg Val Gly Leu Gln Ala Gln Pro Val Pro Asp Glu Ile Val Lys 
        195                 200                 205             


Lys Ile Leu Gly Asn Lys Ala Thr Phe Ser Pro Ile Val Thr Val Glu 
    210                 215                 220                 


Pro Arg Arg Arg Lys Phe His Lys Pro Ile Thr Met Thr Ile Pro Val 
225                 230                 235                 240 


Pro Pro Pro Ser Gly Glu Gly Val Ser Asn Gly Tyr Lys Gly Asp Thr 
                245                 250                 255     


Thr Pro Asn Leu Arg Leu Leu Cys Ser Ile Thr Gly Gly Thr Ser Pro 
            260                 265                 270         


Ala Gln Trp Glu Asp Ile Thr Gly Thr Thr Pro Leu Thr Phe Ile Lys 
        275                 280                 285             


Asp Cys Val Ser Phe Thr Thr Asn Val Ser Ala Arg Phe Trp Leu Ala 
    290                 295                 300                 


Asp Cys His Gln Val Leu Glu Thr Val Gly Leu Ala Thr Gln Leu Tyr 
305                 310                 315                 320 


Arg Glu Leu Ile Cys Val Pro Tyr Met Ala Lys Phe Val Val Phe Ala 
                325                 330                 335     


Lys Met Asn Asp Pro Val Glu Ser Ser Leu Arg Cys Phe Cys Met Thr 
            340                 345                 350         


Asp Asp Lys Val Asp Lys Thr Leu Glu Gln Gln Glu Asn Phe Glu Glu 
        355                 360                 365             


Val Ala Arg Ser Lys Asp Ile Glu Val Leu Glu Gly Lys Pro Ile Tyr 
    370                 375                 380                 


Val Asp Cys Tyr Gly Asn Leu Ala Pro Leu Thr Lys Gly Gly Gln Gln 
385                 390                 395                 400 


Leu Val Phe Asn Phe Tyr Ser Phe Lys Glu Asn Arg Leu Pro Phe Ser 
                405                 410                 415     


Ile Lys Ile Arg Asp Thr Ser Gln Glu Pro Cys Gly Arg Leu Ser Phe 
            420                 425                 430         


Leu Lys Glu Pro Lys Thr Thr Lys Gly Leu Pro Gln Thr Ala Val Cys 
        435                 440                 445             


Asn Leu Asn Ile Thr Leu Pro Ala His Lys Lys Ile Glu Lys Thr Asp 
    450                 455                 460                 


Arg Arg Gln Ser Phe Ala Ser Leu Ala Leu Arg Lys Arg Tyr Ser Tyr 
465                 470                 475                 480 


Leu Thr Glu Pro Gly Met Lys Thr Val Glu Arg Ser Thr Gly Ala Thr 
                485                 490                 495     


Arg Ser Leu Pro Thr Thr Tyr Ser Tyr Lys Pro Phe Phe Ser Thr Arg 
            500                 505                 510         


Pro Tyr Gln Ser Trp Thr Thr Ala Pro Ile Thr Val Pro Gly Pro Ala 
        515                 520                 525             


Lys Ser Gly Phe Thr Ser Leu Ser Ser Ser Ser Ser Asn Thr Pro Ser 
    530                 535                 540                 


Ala Ser Pro Leu Lys Ser Ile Trp Ser Val Ser Thr Pro Ser Pro Ile 
545                 550                 555                 560 


Lys Ser Thr Leu Gly Ala Ser Thr Thr Ser Ser Val Lys Ser Ile Ser 
                565                 570                 575     


Asp Val Ala Ser Pro Ile Arg Ser Phe Arg Thr Met Ser Ser Pro Ile 
            580                 585                 590         


Lys Thr Val Val Ser Gln Ser Pro Tyr Asn Ile Gln Val Ser Ser Gly 
        595                 600                 605             


Thr Leu Ala Arg Ala Pro Ala Val Thr Glu Ala Thr Pro Leu Lys Gly 
    610                 615                 620                 


Leu Ala Ser Asn Ser Thr Phe Ser Ser Arg Thr Ser Pro Val Thr Thr 
625                 630                 635                 640 


Ala Gly Ser Leu Leu Glu Arg Ser Ser Ile Thr Met Thr Pro Pro Ala 
                645                 650                 655     


Ser Pro Lys Ser Asn Ile Asn Met Tyr Ser Ser Ser Leu Pro Phe Lys 
            660                 665                 670         


Ser Ile Ile Thr Ser Ala Ala Pro Leu Ile Ser Ser Pro Leu Lys Ser 
        675                 680                 685             


Val Val Ser Pro Val Lys Ser Ala Val Asp Val Ile Ser Ser Ala Lys 
    690                 695                 700                 


Ile Thr Met Ala Ser Ser Leu Ser Ser Pro Val Lys Gln Met Pro Gly 
705                 710                 715                 720 


His Ala Glu Val Ala Leu Val Asn Gly Ser Ile Ser Pro Leu Lys Tyr 
                725                 730                 735     


Pro Ser Ser Ser Thr Leu Ile Asn Gly Cys Lys Ala Thr Ala Thr Leu 
            740                 745                 750         


Gln Glu Lys Ile Ser Ser Ala Thr Asn Ser Val Ser Ser Val Val Ser 
        755                 760                 765             


Ala Ala Thr Asp Thr Val Glu Lys Val Phe Ser Thr Thr Thr Ala Met 
    770                 775                 780                 


Pro Phe Ser Pro Leu Arg Ser Tyr Val Ser Ala Ala Pro Ser Ala Phe 
785                 790                 795                 800 


Gln Ser Leu Arg Thr Pro Ser Ala Ser Ala Leu Tyr Thr Ser Leu Gly 
                805                 810                 815     


Ser Ser Ile Ser Ala Thr Thr Ser Ser Val Thr Ser Ser Ile Ile Thr 
            820                 825                 830         


Val Pro Val Tyr Ser Val Val Asn Val Leu Pro Glu Pro Ala Leu Lys 
        835                 840                 845             


Lys Leu Pro Asp Ser Asn Ser Phe Thr Lys Ser Ala Ala Ala Leu Leu 
    850                 855                 860                 


Ser Pro Ile Lys Thr Leu Thr Thr Glu Thr His Pro Gln Pro His Phe 
865                 870                 875                 880 


Ser Arg Thr Ser Ser Pro Val Lys Ser Ser Leu Phe Leu Ala Pro Ser 
                885                 890                 895     


Ala Leu Lys Leu Ser Thr Pro Ser Ser Leu Ser Ser Ser Gln Glu Ile 
            900                 905                 910         


Leu Lys Asp Val Ala Glu Met Lys Glu Asp Leu Met Arg Met Thr Ala 
        915                 920                 925             


Ile Leu Gln Thr Asp Val Pro Glu Glu Lys Pro Phe Gln Pro Glu Leu 
    930                 935                 940                 


Pro Lys Glu Gly Arg Ile Asp Asp Glu Glu Pro Phe Lys Ile Val Glu 
945                 950                 955                 960 


Lys Val Lys Glu Asp Leu Val Lys Val Ser Glu Ile Leu Lys Lys Asp 
                965                 970                 975     


Val Cys Val Asp Asn Lys Gly Ser Pro Lys Ser Pro Lys Ser Asp Lys 
            980                 985                 990         


Gly His Ser Pro Glu Asp Asp Trp  Ile Glu Phe Ser Ser  Glu Glu Ile 
        995                 1000                 1005             


Arg Glu  Ala Arg Gln Gln Ala  Ala Ala Ser Gln Ser  Pro Ser Leu 
    1010                 1015                 1020             


Pro Glu  Arg Val Gln Val Lys  Ala Lys Ala Ala Ser  Glu Lys Asp 
    1025                 1030                 1035             


Tyr Asn  Leu Thr Lys Val Ile  Asp Tyr Leu Thr Asn  Asp Ile Gly 
    1040                 1045                 1050             


Ser Ser  Ser Leu Thr Asn Leu  Lys Tyr Lys Phe Glu  Asp Ala Lys 
    1055                 1060                 1065             


Lys Asp  Gly Glu Glu Arg Gln  Lys Arg Val Leu Lys  Pro Ala Ile 
    1070                 1075                 1080             


Ala Leu  Gln Glu His Lys Leu  Lys Met Pro Pro Ala  Ser Met Arg 
    1085                 1090                 1095             


Thr Ser  Thr Ser Glu Lys Glu  Leu Cys Lys Met Ala  Asp Ser Phe 
    1100                 1105                 1110             


Phe Gly  Thr Asp Thr Ile Leu  Glu Ser Pro Asp Asp  Phe Ser Gln 
    1115                 1120                 1125             


His Asp  Gln Asp Lys Ser Pro  Leu Ser Asp Ser Gly  Phe Glu Thr 
    1130                 1135                 1140             


Arg Ser  Glu Lys Thr Pro Ser  Ala Pro Gln Ser Ala  Glu Ser Thr 
    1145                 1150                 1155             


Gly Pro  Lys Pro Leu Phe His  Glu Val Pro Ile Pro  Pro Val Ile 
    1160                 1165                 1170             


Thr Glu  Thr Arg Thr Glu Val  Val His Val Ile Arg  Ser Tyr Asp 
    1175                 1180                 1185             


Pro Ser  Ala Gly Asp Val Pro  Gln Thr Gln Pro Glu  Glu Pro Val 
    1190                 1195                 1200             


Ser Pro  Lys Pro Ser Pro Thr  Phe Met Glu Leu Glu  Pro Lys Pro 
    1205                 1210                 1215             


Thr Thr  Ser Ser Ile Lys Glu  Lys Val Lys Ala Phe  Gln Met Lys 
    1220                 1225                 1230             


Ala Ser  Ser Glu Glu Asp Asp  His Asn Arg Val Leu  Ser Lys Gly 
    1235                 1240                 1245             


Met Arg  Val Lys Glu Glu Thr  His Ile Thr Thr Thr  Thr Arg Met 
    1250                 1255                 1260             


Val Tyr  His Ser Pro Pro Gly  Gly Glu Gly Ala Ser  Glu Arg Ile 
    1265                 1270                 1275             


Glu Glu  Thr Met Ser Val His  Asp Ile Met Lys Ala  Phe Gln Ser 
    1280                 1285                 1290             


Gly Arg  Asp Pro Ser Lys Glu  Leu Ala Gly Leu Phe  Glu His Lys 
    1295                 1300                 1305             


Ser Ala  Val Ser Pro Asp Val  His Lys Ser Ala Ala  Glu Thr Ser 
    1310                 1315                 1320             


Ala Gln  His Ala Glu Lys Asp  Asn Gln Met Lys Pro  Lys Leu Glu 
    1325                 1330                 1335             


Arg Ile  Ile Glu Val His Ile  Glu Lys Gly Pro Gln  Ser Pro Cys 
    1340                 1345                 1350             


Glu Arg  Thr Asp Ile Arg Met  Ala Ile Val Ala Asp  His Leu Gly 
    1355                 1360                 1365             


Leu Ser  Trp Thr Glu Leu Ala  Arg Glu Leu Asn Phe  Ser Val Asp 
    1370                 1375                 1380             


Glu Ile  Asn Gln Ile Arg Val  Glu Asn Pro Asn Ser  Leu Ile Ser 
    1385                 1390                 1395             


Gln Ser  Phe Met Leu Leu Lys  Lys Trp Val Thr Arg  Asp Gly Lys 
    1400                 1405                 1410             


Asn Ala  Thr Thr Asp Ala Leu  Thr Ser Val Leu Thr  Lys Ile Asn 
    1415                 1420                 1425             


Arg Ile  Asp Ile Val Thr Leu  Leu Glu Gly Pro Ile  Phe Asp Tyr 
    1430                 1435                 1440             


Gly Asn  Ile Ser Gly Thr Arg  Ser Phe Ala Asp Glu  Asn Asn Val 
    1445                 1450                 1455             


Phe His  Asp Pro Val Asp Gly  Trp Gln Asn Glu Thr  Ser Ser Gly 
    1460                 1465                 1470             


Asn Leu  Glu Ser Cys Ala Gln  Ala Arg Arg Val Thr  Gly Gly Leu 
    1475                 1480                 1485             


Leu Asp  Arg Leu Asp Asp Ser  Pro Asp Gln Cys Arg  Asp Ser Ile 
    1490                 1495                 1500             


Thr Ser  Tyr Leu Lys Gly Glu  Ala Gly Lys Phe Glu  Ala Asn Gly 
    1505                 1510                 1515             


Ser His  Thr Glu Ile Thr Pro  Glu Ala Lys Thr Lys  Ser Tyr Phe 
    1520                 1525                 1530             


Pro Glu  Ser Gln Asn Asp Val  Gly Lys Gln Ser Thr  Lys Glu Thr 
    1535                 1540                 1545             


Leu Lys  Pro Lys Ile His Gly  Ser Gly His Val Glu  Glu Pro Ala 
    1550                 1555                 1560             


Ser Pro  Leu Ala Ala Tyr Gln  Lys Ser Leu Glu Glu  Thr Ser Lys 
    1565                 1570                 1575             


Leu Ile  Ile Glu Glu Thr Lys  Pro Cys Val Pro Val  Ser Met Lys 
    1580                 1585                 1590             


Lys Met  Ser Arg Thr Ser Pro  Ala Asp Gly Lys Pro  Arg Leu Ser 
    1595                 1600                 1605             


Leu His  Glu Glu Glu Gly Ser  Ser Gly Ser Glu Gln  Lys Gln Gly 
    1610                 1615                 1620             


Glu Gly  Phe Lys Val Lys Thr  Lys Lys Glu Ile Arg  His Val Glu 
    1625                 1630                 1635             


Lys Lys  Ser His Ser 
    1640             


<210>  89
<211>  973
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 6

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  89

Xaa Pro Val Ile Val Glu Ile Pro His Phe Gly Ser Met Arg Gly Lys 
1               5                   10                  15      


Glu Arg Glu Leu Ile Val Leu Arg Ser Glu Asn Gly Glu Thr Trp Lys 
            20                  25                  30          


Glu His Gln Phe Asp Ser Lys Asn Glu Asp Leu Thr Glu Leu Leu Asn 
        35                  40                  45              


Gly Met Asp Glu Glu Leu Asp Ser Pro Glu Glu Leu Gly Lys Lys Arg 
    50                  55                  60                  


Ile Cys Arg Ile Ile Thr Lys Asp Phe Pro Gln Tyr Phe Ala Val Val 
65                  70                  75                  80  


Ser Arg Ile Lys Gln Glu Ser Asn Gln Ile Gly Pro Glu Gly Gly Ile 
                85                  90                  95      


Leu Ser Ser Thr Thr Val Pro Leu Val Gln Ala Ser Phe Pro Glu Gly 
            100                 105                 110         


Ala Leu Thr Lys Arg Ile Arg Val Gly Leu Gln Ala Gln Pro Val Pro 
        115                 120                 125             


Asp Glu Ile Val Lys Lys Ile Leu Gly Asn Lys Ala Thr Phe Ser Pro 
    130                 135                 140                 


Ile Val Thr Val Glu Pro Arg Arg Arg Lys Phe His Lys Pro Ile Thr 
145                 150                 155                 160 


Met Thr Ile Pro Val Pro Pro Pro Ser Gly Glu Gly Val Ser Asn Gly 
                165                 170                 175     


Tyr Lys Gly Asp Thr Thr Pro Asn Leu Arg Leu Leu Cys Ser Ile Thr 
            180                 185                 190         


Gly Gly Thr Ser Pro Ala Gln Trp Glu Asp Ile Thr Gly Thr Thr Pro 
        195                 200                 205             


Leu Thr Phe Ile Lys Asp Cys Val Ser Phe Thr Thr Asn Val Ser Ala 
    210                 215                 220                 


Arg Phe Trp Leu Ala Asp Cys His Gln Val Leu Glu Thr Val Gly Leu 
225                 230                 235                 240 


Ala Thr Gln Leu Tyr Arg Glu Leu Ile Cys Val Pro Tyr Met Ala Lys 
                245                 250                 255     


Phe Val Val Phe Ala Lys Met Asn Asp Pro Val Glu Ser Ser Leu Arg 
            260                 265                 270         


Cys Phe Cys Met Thr Asp Asp Lys Val Asp Lys Thr Leu Glu Gln Gln 
        275                 280                 285             


Glu Asn Phe Glu Glu Val Ala Arg Ser Lys Asp Ile Glu Val Leu Glu 
    290                 295                 300                 


Gly Lys Pro Ile Tyr Val Asp Cys Tyr Gly Asn Leu Ala Pro Leu Thr 
305                 310                 315                 320 


Lys Gly Gly Gln Gln Leu Val Phe Asn Phe Tyr Ser Phe Lys Glu Asn 
                325                 330                 335     


Arg Leu Pro Phe Ser Ile Lys Ile Arg Asp Thr Ser Gln Glu Pro Cys 
            340                 345                 350         


Gly Arg Leu Ser Phe Leu Lys Glu Pro Lys Thr Thr Lys Gly Leu Pro 
        355                 360                 365             


Gln Thr Ala Val Cys Asn Leu Asn Ile Thr Leu Pro Ala His Lys Lys 
    370                 375                 380                 


Glu Thr Glu Ser Asp Gln Asp Asp Glu Ile Glu Lys Thr Asp Arg Arg 
385                 390                 395                 400 


Gln Ser Phe Ala Ser Leu Ala Leu Arg Pro Gln Ser Pro Cys Glu Arg 
                405                 410                 415     


Thr Asp Ile Arg Met Ala Ile Val Ala Asp His Leu Gly Leu Ser Trp 
            420                 425                 430         


Thr Glu Leu Ala Arg Glu Leu Asn Phe Ser Val Asp Glu Ile Asn Gln 
        435                 440                 445             


Ile Arg Val Glu Asn Pro Asn Ser Leu Ile Ser Gln Ser Phe Met Leu 
    450                 455                 460                 


Leu Lys Lys Trp Val Thr Arg Asp Gly Lys Asn Ala Thr Thr Asp Ala 
465                 470                 475                 480 


Leu Thr Ser Val Leu Thr Lys Ile Asn Arg Ile Asp Ile Val Thr Leu 
                485                 490                 495     


Leu Glu Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser Gly Thr Arg Ser 
            500                 505                 510         


Phe Ala Asp Glu Asn Asn Val Phe His Asp Pro Val Asp Gly Tyr Pro 
        515                 520                 525             


Ser Leu Gln Val Glu Leu Glu Thr Pro Thr Gly Leu His Tyr Thr Pro 
    530                 535                 540                 


Pro Thr Pro Phe Gln Gln Asp Asp Tyr Phe Ser Asp Ile Ser Ser Ile 
545                 550                 555                 560 


Glu Ser Pro Leu Arg Thr Pro Ser Arg Leu Ser Asp Gly Leu Val Pro 
                565                 570                 575     


Ser Gln Gly Asn Ile Glu His Ser Ala Asp Gly Pro Pro Val Val Thr 
            580                 585                 590         


Ala Glu Asp Ala Ser Leu Glu Asp Ser Lys Leu Glu Asp Ser Val Pro 
        595                 600                 605             


Leu Thr Glu Met Pro Glu Ala Val Asp Val Asp Glu Ser Gln Leu Glu 
    610                 615                 620                 


Asn Val Cys Leu Ser Glu Tyr Pro Gln Tyr Leu Gly Asn Leu Ala Gly 
625                 630                 635                 640 


Ser Pro Lys Asp Val Lys Pro Ala Glu Pro Arg Lys Leu Gly Val Ser 
                645                 650                 655     


Ser Glu Gln Gln Glu Lys Gly Lys Ser Gly Pro Asp Glu Glu Met Met 
            660                 665                 670         


Glu Glu Lys Leu Lys Ser Leu Phe Glu Asp Ile Gln Leu Glu Glu Gly 
        675                 680                 685             


Val Glu Ser Glu Glu Met Thr Glu Glu Lys Val Gln Ala Ile Leu Lys 
    690                 695                 700                 


Arg Val Gln Gln Ala Glu Leu Glu Met Ser Ser Ile Thr Gly Trp Gln 
705                 710                 715                 720 


Asn Glu Thr Ser Ser Gly Asn Leu Glu Ser Cys Ala Gln Ala Arg Arg 
                725                 730                 735     


Val Thr Gly Gly Leu Leu Asp Arg Leu Asp Asp Ser Pro Asp Gln Cys 
            740                 745                 750         


Arg Asp Ser Ile Thr Ser Tyr Leu Lys Gly Glu Ala Gly Lys Phe Glu 
        755                 760                 765             


Ala Asn Gly Ser His Thr Glu Ile Thr Pro Glu Ala Lys Thr Lys Ser 
    770                 775                 780                 


Tyr Phe Pro Glu Ser Gln Asn Asp Val Gly Lys Gln Ser Thr Lys Glu 
785                 790                 795                 800 


Thr Leu Lys Pro Lys Ile His Gly Ser Gly His Val Glu Glu Pro Ala 
                805                 810                 815     


Ser Pro Leu Ala Ala Tyr Gln Lys Ser Leu Glu Glu Thr Ser Lys Leu 
            820                 825                 830         


Ile Ile Glu Glu Thr Lys Pro Cys Val Pro Val Ser Met Lys Lys Met 
        835                 840                 845             


Ser Arg Thr Ser Pro Ala Asp Gly Lys Pro Arg Leu Ser Leu His Glu 
    850                 855                 860                 


Glu Glu Gly Ser Ser Gly Ser Glu Gln Lys Asp Leu Lys Asp Ser Glu 
865                 870                 875                 880 


Ser Asp Ser Ser Ser Glu Glu Glu Arg Arg Val Thr Thr Arg Val Ile 
                885                 890                 895     


Arg Arg Arg Leu Ile Ile Lys Gly Glu Glu Ala Lys Asn Ile Pro Gly 
            900                 905                 910         


Glu Ser Val Thr Glu Glu Gln Phe Thr Asp Glu Glu Gly Asn Leu Ile 
        915                 920                 925             


Thr Arg Lys Ile Thr Arg Lys Val Leu Arg Arg Ile Val Ile Pro Gln 
    930                 935                 940                 


Glu Arg Lys Arg Asp Asp Val Gln Gly Glu Gly Phe Lys Val Lys Thr 
945                 950                 955                 960 


Lys Lys Glu Ile Arg His Val Glu Lys Lys Ser His Ser 
                965                 970             


<210>  90
<211>  459
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 7

<400>  90

Pro Lys Thr Thr Lys Gly Leu Pro Gln Thr Ala Val Cys Asn Leu Asn 
1               5                   10                  15      


Ile Thr Leu Pro Ala His Lys Lys Glu Thr Glu Ser Asp Gln Asp Asp 
            20                  25                  30          


Glu Ile Glu Lys Thr Asp Arg Arg Gln Ser Phe Ala Ser Leu Ala Leu 
        35                  40                  45              


Arg Lys Arg Tyr Ser Tyr Leu Thr Glu Pro Gly Met Ser Pro Gln Ser 
    50                  55                  60                  


Pro Cys Glu Arg Thr Asp Ile Arg Met Ala Ile Val Ala Asp His Leu 
65                  70                  75                  80  


Gly Leu Ser Trp Thr Glu Leu Ala Arg Glu Leu Asn Phe Ser Val Asp 
                85                  90                  95      


Glu Ile Asn Gln Ile Arg Val Glu Asn Pro Asn Ser Leu Ile Ser Gln 
            100                 105                 110         


Ser Phe Met Leu Leu Lys Lys Trp Val Thr Arg Asp Gly Lys Asn Ala 
        115                 120                 125             


Thr Thr Asp Ala Leu Thr Ser Val Leu Thr Lys Ile Asn Arg Ile Asp 
    130                 135                 140                 


Ile Val Thr Leu Leu Glu Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser 
145                 150                 155                 160 


Gly Thr Arg Ser Phe Ala Asp Glu Asn Asn Val Phe His Asp Pro Val 
                165                 170                 175     


Asp Gly Tyr Pro Ser Leu Gln Val Glu Leu Glu Thr Pro Thr Gly Leu 
            180                 185                 190         


His Tyr Thr Pro Pro Thr Pro Phe Gln Gln Asp Asp Tyr Phe Ser Asp 
        195                 200                 205             


Ile Ser Ser Ile Glu Ser Pro Leu Arg Thr Pro Ser Arg Leu Ser Asp 
    210                 215                 220                 


Gly Leu Val Pro Ser Gln Gly Asn Ile Glu His Ser Ala Asp Gly Pro 
225                 230                 235                 240 


Pro Val Val Thr Ala Glu Asp Ala Ser Leu Glu Asp Ser Lys Leu Glu 
                245                 250                 255     


Asp Ser Val Pro Leu Thr Glu Met Pro Glu Ala Val Asp Val Asp Glu 
            260                 265                 270         


Ser Gln Leu Glu Asn Val Cys Leu Ser Trp Gln Asn Glu Thr Ser Ser 
        275                 280                 285             


Gly Asn Leu Glu Ser Cys Ala Gln Ala Arg Arg Val Thr Gly Gly Leu 
    290                 295                 300                 


Leu Asp Arg Leu Asp Asp Ser Pro Asp Gln Cys Arg Asp Ser Ile Thr 
305                 310                 315                 320 


Ser Tyr Leu Lys Gly Glu Ala Gly Lys Phe Glu Ala Asn Gly Ser His 
                325                 330                 335     


Thr Glu Ile Thr Pro Glu Ala Lys Thr Lys Ser Tyr Phe Pro Glu Ser 
            340                 345                 350         


Gln Asn Asp Val Gly Lys Gln Ser Thr Lys Glu Thr Leu Lys Pro Lys 
        355                 360                 365             


Ile His Gly Ser Gly His Val Glu Glu Pro Ala Ser Pro Leu Ala Ala 
    370                 375                 380                 


Tyr Gln Lys Ser Leu Glu Glu Thr Ser Lys Leu Ile Ile Glu Glu Thr 
385                 390                 395                 400 


Lys Pro Cys Val Pro Val Ser Met Lys Lys Met Ser Arg Thr Ser Pro 
                405                 410                 415     


Ala Asp Gly Lys Pro Arg Leu Ser Leu His Glu Glu Glu Gly Ser Ser 
            420                 425                 430         


Gly Ser Glu Gln Lys Gln Gly Glu Gly Phe Lys Val Lys Thr Lys Lys 
        435                 440                 445             


Glu Ile Arg His Val Glu Lys Lys Ser His Ser 
    450                 455                 


<210>  91
<211>  96
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 8

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  91

Xaa Leu Ala Arg Glu Leu Asn Phe Ser Val Asp Glu Ile Asn Gln Ile 
1               5                   10                  15      


Arg Val Glu Asn Pro Asn Ser Leu Ile Ser Gln Ser Phe Met Leu Leu 
            20                  25                  30          


Lys Lys Trp Val Thr Arg Asp Gly Lys Asn Ala Thr Thr Asp Ala Leu 
        35                  40                  45              


Thr Ser Val Leu Thr Lys Ile Asn Arg Ile Asp Ile Val Thr Leu Leu 
    50                  55                  60                  


Glu Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser Gly Thr Arg Ser Phe 
65                  70                  75                  80  


Ala Asp Glu Asn Asn Val Phe His Asp Pro Val Asp Gly Asn Arg Ile 
                85                  90                  95      


<210>  92
<211>  322
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 9

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  92

Xaa Gly Pro Asp Glu Asp Lys Pro Pro Ser Lys Ser Ser Ser Ser Glu 
1               5                   10                  15      


Lys Thr Pro Asp Lys Thr Asp Gln Lys Ser Gly Ala Gln Phe Phe Thr 
            20                  25                  30          


Leu Glu Gly Arg His Pro Asp Arg Ser Val Phe Pro Asp Thr Tyr Phe 
        35                  40                  45              


Ser Tyr Lys Val Asp Glu Glu Phe Ala Thr Pro Phe Lys Thr Val Ala 
    50                  55                  60                  


Thr Lys Gly Leu Asp Phe Asp Pro Trp Ser Asn Asn Arg Gly Asp Asp 
65                  70                  75                  80  


Glu Val Phe Asp Ser Lys Ser Arg Glu Asp Glu Thr Lys Pro Phe Gly 
                85                  90                  95      


Leu Ala Val Glu Asp Arg Ser Pro Ala Thr Thr Pro Asp Thr Thr Pro 
            100                 105                 110         


Ala Arg Thr Pro Thr Asp Glu Ser Thr Pro Thr Ser Glu Pro Asn Pro 
        115                 120                 125             


Phe Pro Phe His Glu Gly Lys Met Phe Glu Met Thr Arg Ser Gly Ala 
    130                 135                 140                 


Ile Asp Met Ser Lys Arg Asp Phe Val Glu Glu Arg Leu Gln Phe Phe 
145                 150                 155                 160 


Gln Ile Gly Pro Gln Ser Pro Cys Glu Arg Thr Asp Ile Arg Met Ala 
                165                 170                 175     


Ile Val Ala Asp His Leu Gly Leu Ser Trp Thr Glu Leu Ala Arg Glu 
            180                 185                 190         


Leu Asn Phe Ser Val Asp Glu Ile Asn Gln Ile Arg Val Glu Asn Pro 
        195                 200                 205             


Asn Ser Leu Ile Ser Gln Ser Phe Met Leu Leu Lys Lys Trp Val Thr 
    210                 215                 220                 


Arg Asp Gly Lys Asn Ala Thr Thr Asp Ala Leu Thr Ser Val Leu Thr 
225                 230                 235                 240 


Lys Ile Asn Arg Ile Asp Ile Val Thr Leu Leu Glu Gly Pro Ile Phe 
                245                 250                 255     


Asp Tyr Gly Asn Ile Ser Gly Thr Arg Ser Phe Ala Asp Glu Asn Asn 
            260                 265                 270         


Val Phe His Asp Pro Val Asp Gly Trp Gln Asn Glu Thr Ser Ser Gly 
        275                 280                 285             


Asn Leu Glu Ser Cys Ala Gln Ala Arg Arg Val Thr Gly Gly Leu Leu 
    290                 295                 300                 


Asp Arg Leu Asp Asp Ser Pro Asp Gln Cys Arg Asp Ser Ile Thr Ser 
305                 310                 315                 320 


Tyr Leu 
        


<210>  93
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Ala Val Glu Glu Gly Glu Ser Phe Pro Glu Gln Ser Asp Ala Asn 
1               5                   10                  15      


Ala Ser Tyr Leu Arg Ala Ala Arg Ala Gly His Leu Glu Lys Ala Leu 
            20                  25                  30          


Asp Tyr Ile Lys Asn Gly Val Asp Ile Asn Ile Cys Asn Gln Asn Gly 
        35                  40                  45              


Leu Asn Ala Leu His Leu Ala Ser Lys Glu Gly His Val Glu Val Val 
    50                  55                  60                  


Ser Glu Leu Leu Gln Arg Glu Ala Asn Val Asp Ala Ala Thr Lys Lys 
65                  70                  75                  80  


Gly Asn Thr Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val 
                85                  90                  95      


Val Lys Val Leu Val Thr Asn Gly Ala Asn Val Asn Ala Gln Ser Gln 
            100                 105                 110         


Asn Gly Phe Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Leu Glu 
        115                 120                 125             


Val Val Lys Phe Leu Leu Asp Asn Gly Ala Ser Gln Ser Leu Ala Thr 
    130                 135                 140                 


Glu Asp Gly Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Asp 
145                 150                 155                 160 


Gln Val Val Ser Leu Leu Leu Glu Asn Asp Thr Lys Gly Lys Val Arg 
                165                 170                 175     


Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp Thr Lys Ala Ala 
            180                 185                 190         


Ala Leu Leu Leu Gln Asn Asp Asn Asn Ala Asp Val Glu Ser Lys Ser 
        195                 200                 205             


Gly Phe Thr Pro Leu His Ile Ala Ala His Tyr Gly Asn Ile Asn Val 
    210                 215                 220                 


Ala Thr Leu Leu Leu Asn Arg Ala Ala Ala Val Asp Phe Thr Ala Arg 
225                 230                 235                 240 


Asn Asp Ile Thr Pro Leu His Val Ala Ser Lys Arg Gly Asn Ala Asn 
                245                 250                 255     


Met Val Lys Leu Leu Leu Asp Arg Gly Ala Lys Ile Asp Ala Lys Thr 
            260                 265                 270         


Arg 
    


<210>  94
<211>  273
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 11

<400>  94

Met Ala Val Glu Glu Gly Glu Ser Phe Pro Glu Gln Ser Asp Ala Asn 
1               5                   10                  15      


Ala Ser Tyr Leu Arg Ala Ala Arg Ala Gly His Leu Glu Lys Ala Leu 
            20                  25                  30          


Asp Tyr Ile Lys Asn Gly Val Asp Ile Asn Ile Cys Asn Gln Asn Gly 
        35                  40                  45              


Leu Asn Ala Leu His Leu Ala Ser Lys Glu Gly His Val Glu Val Val 
    50                  55                  60                  


Ser Glu Leu Leu Gln Arg Glu Ala Asn Val Asp Ala Ala Thr Lys Lys 
65                  70                  75                  80  


Gly Asn Thr Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val 
                85                  90                  95      


Val Lys Val Leu Val Thr Asn Gly Ala Asn Val Asn Ala Gln Ser Gln 
            100                 105                 110         


Asn Gly Phe Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Leu Glu 
        115                 120                 125             


Val Val Lys Phe Leu Leu Asp Asn Gly Ala Ser Gln Ser Leu Ala Thr 
    130                 135                 140                 


Glu Asp Gly Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Asp 
145                 150                 155                 160 


Gln Val Val Ser Leu Leu Leu Glu Asn Asp Thr Lys Gly Lys Val Arg 
                165                 170                 175     


Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp Thr Lys Ala Ala 
            180                 185                 190         


Ala Leu Leu Leu Gln Asn Asp Asn Asn Ala Asp Val Glu Ser Lys Ser 
        195                 200                 205             


Gly Phe Thr Pro Leu His Ile Ala Ala His Tyr Gly Asn Ile Asn Val 
    210                 215                 220                 


Ala Thr Leu Leu Leu Asn Arg Ala Ala Ala Val Asp Phe Thr Ala Arg 
225                 230                 235                 240 


Asn Asp Ile Thr Pro Leu His Val Ala Ser Lys Arg Gly Asn Ala Asn 
                245                 250                 255     


Met Val Lys Leu Leu Leu Asp Arg Gly Ala Lys Ile Asp Ala Lys Thr 
            260                 265                 270         


Arg 
    


<210>  95
<211>  241
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 12

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  95

Xaa Thr Val Ala Thr Lys Gly Leu Asp Phe Asp Pro Trp Ser Asn Asn 
1               5                   10                  15      


Arg Gly Asp Asp Glu Val Phe Asp Ser Lys Ser Arg Glu Asp Glu Thr 
            20                  25                  30          


Lys Pro Phe Gly Leu Ala Val Glu Asp Arg Ser Pro Ala Thr Thr Pro 
        35                  40                  45              


Asp Thr Thr Pro Ala Arg Thr Pro Thr Asp Glu Ser Thr Pro Thr Ser 
    50                  55                  60                  


Glu Pro Asn Pro Phe Pro Phe His Glu Gly Lys Met Phe Glu Met Thr 
65                  70                  75                  80  


Arg Ser Gly Ala Ile Asp Met Ser Lys Arg Asp Phe Val Glu Glu Arg 
                85                  90                  95      


Leu Gln Phe Phe Gln Ile Gly Pro Gln Ser Pro Cys Glu Arg Thr Asp 
            100                 105                 110         


Ile Arg Met Ala Ile Val Ala Asp His Leu Gly Leu Ser Trp Thr Glu 
        115                 120                 125             


Leu Ala Arg Glu Leu Asn Phe Ser Val Asp Glu Ile Asn Gln Ile Arg 
    130                 135                 140                 


Val Glu Asn Pro Asn Ser Leu Ile Ser Gln Ser Phe Met Leu Leu Lys 
145                 150                 155                 160 


Lys Trp Val Thr Arg Asp Gly Lys Asn Ala Thr Thr Asp Ala Leu Thr 
                165                 170                 175     


Ser Val Leu Thr Lys Ile Asn Arg Ile Asp Ile Val Thr Leu Leu Glu 
            180                 185                 190         


Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser Gly Thr Arg Ser Phe Ala 
        195                 200                 205             


Asp Glu Asn Asn Val Phe His Asp Pro Val Asp Gly Tyr Pro Ser Leu 
    210                 215                 220                 


Gln Val Glu Leu Glu Thr Pro Thr Gly Leu His Tyr Thr Pro Pro Thr 
225                 230                 235                 240 


Pro 
    


<210>  96
<211>  178
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 13

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  96

Xaa Trp Gln Asn Glu Thr Ser Ser Gly Asn Leu Glu Ser Cys Ala Gln 
1               5                   10                  15      


Ala Arg Arg Val Thr Gly Gly Leu Leu Asp Arg Leu Asp Asp Ser Pro 
            20                  25                  30          


Asp Gln Cys Arg Asp Ser Ile Thr Ser Tyr Leu Lys Gly Glu Ala Gly 
        35                  40                  45              


Lys Phe Glu Ala Asn Gly Ser His Thr Glu Ile Thr Pro Glu Ala Lys 
    50                  55                  60                  


Thr Lys Ser Tyr Phe Pro Glu Ser Gln Asn Asp Val Gly Lys Gln Ser 
65                  70                  75                  80  


Thr Lys Glu Thr Leu Lys Pro Lys Ile His Gly Ser Gly His Val Glu 
                85                  90                  95      


Glu Pro Ala Ser Pro Leu Ala Ala Tyr Gln Lys Ser Leu Glu Glu Thr 
            100                 105                 110         


Ser Lys Leu Ile Ile Glu Glu Thr Lys Pro Cys Val Pro Val Ser Met 
        115                 120                 125             


Lys Lys Met Ser Arg Thr Ser Pro Ala Asp Gly Lys Pro Arg Leu Ser 
    130                 135                 140                 


Leu His Glu Glu Glu Gly Ser Ser Gly Ser Glu Gln Lys Gly Glu Gly 
145                 150                 155                 160 


Phe Lys Val Lys Thr Lys Lys Glu Ile Arg His Val Glu Lys Lys Ser 
                165                 170                 175     


His Ser 
        


<210>  97
<211>  86
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 14

<400>  97

Met Asn Val Pro Glu Thr Met Asn Glu Val Leu Asp Met Ser Asp Asp 
1               5                   10                  15      


Glu Gly Asn Arg Cys Thr Trp Tyr Lys Ile Pro Lys Val Gln Glu Phe 
            20                  25                  30          


Thr Val Lys Ser Glu Asp Ala Met Thr Gly Asp Thr Asp Lys Tyr Leu 
        35                  40                  45              


Gly Pro Gln Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ala Glu 
    50                  55                  60                  


Gly Tyr Met Gly Phe Ser Leu Gly Ala Arg Ser Ala Arg Tyr Phe Val 
65                  70                  75                  80  


Val Ala Val Phe His Ser 
                85      


<210>  98
<211>  195
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 15

<400>  98

Met Thr Gly Asp Thr Asp Lys Tyr Leu Gly Pro Gln Asp Leu Lys Glu 
1               5                   10                  15      


Leu Gly Asp Asp Ser Leu Pro Ala Glu Gly Tyr Met Gly Phe Ser Leu 
            20                  25                  30          


Gly Ala Arg Ser Ala Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser Tyr 
        35                  40                  45              


Thr Leu Asn Arg Ser Ser Tyr Ala Arg Asp Ser Met Met Ile Glu Glu 
    50                  55                  60                  


Leu Leu Val Pro Ser Lys Glu Gln His Leu Thr Phe Thr Arg Glu Phe 
65                  70                  75                  80  


Asp Ser Asp Ser Leu Arg His Tyr Ser Trp Ala Ala Asp Thr Leu Asp 
                85                  90                  95      


Asn Val Asn Leu Val Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser 
            100                 105                 110         


Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg Gly Ser Arg His His 
        115                 120                 125             


Gly Met Arg Ile Ile Ile Pro Pro Arg Lys Cys Thr Ala Pro Thr Arg 
    130                 135                 140                 


Ile Thr Cys Arg Leu Val Lys Arg His Lys Leu Ala Asn Pro Pro Pro 
145                 150                 155                 160 


Met Val Glu Gly Glu Gly Leu Ala Ser Arg Leu Val Glu Met Gly Pro 
                165                 170                 175     


Ala Gly Ala Gln Phe Leu Gly Pro Val Ile Val Glu Ile Pro His Phe 
            180                 185                 190         


Gly Ser Met 
        195 


<210>  99
<211>  166
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 15

<400>  99

Ser Pro Asp Gln Cys Arg Asp Ser Ile Thr Ser Tyr Leu Lys Gly Glu 
1               5                   10                  15      


Ala Gly Lys Phe Glu Ala Asn Gly Ser His Thr Glu Ile Thr Pro Glu 
            20                  25                  30          


Ala Lys Thr Lys Ser Tyr Phe Pro Glu Ser Gln Asn Asp Val Gly Lys 
        35                  40                  45              


Gln Ser Thr Lys Glu Thr Leu Lys Pro Lys Ile His Gly Ser Gly His 
    50                  55                  60                  


Val Glu Glu Pro Ala Ser Pro Leu Ala Ala Tyr Gln Lys Ser Leu Glu 
65                  70                  75                  80  


Glu Thr Ser Lys Leu Ile Ile Glu Glu Thr Lys Pro Cys Val Pro Val 
                85                  90                  95      


Ser Met Lys Lys Met Ser Arg Thr Ser Pro Ala Asp Gly Lys Pro Arg 
            100                 105                 110         


Leu Ser Leu His Glu Glu Glu Gly Ser Ser Gly Ser Glu Gln Lys Val 
        115                 120                 125             


Lys Ser Pro Gly Ala Ala Pro Thr Arg Met Thr Ala Cys Cys Tyr Lys 
    130                 135                 140                 


Gln Gly Glu Gly Phe Lys Val Lys Thr Lys Lys Glu Ile Arg His Val 
145                 150                 155                 160 


Glu Lys Lys Ser His Ser 
                165     


<210>  100
<211>  217
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 17

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  100

Xaa Leu Ala Arg Glu Leu Asn Phe Ser Val Asp Glu Ile Asn Gln Ile 
1               5                   10                  15      


Arg Val Glu Asn Pro Asn Ser Leu Ile Ser Gln Ser Phe Met Leu Leu 
            20                  25                  30          


Lys Lys Trp Val Thr Arg Asp Gly Lys Asn Ala Thr Thr Asp Ala Leu 
        35                  40                  45              


Thr Ser Val Leu Thr Lys Ile Asn Arg Ile Asp Ile Val Thr Leu Leu 
    50                  55                  60                  


Glu Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser Gly Thr Arg Ser Phe 
65                  70                  75                  80  


Ala Asp Glu Asn Asn Val Phe His Asp Pro Val Asp Val Ser Pro Asn 
                85                  90                  95      


Val Leu Ser Ser Ile Gly Tyr Pro Ser Leu Gln Val Glu Leu Glu Thr 
            100                 105                 110         


Pro Thr Gly Leu His Tyr Thr Pro Pro Thr Pro Phe Gln Gln Asp Asp 
        115                 120                 125             


Tyr Phe Ser Asp Ile Ser Ser Ile Glu Ser Pro Leu Arg Thr Pro Ser 
    130                 135                 140                 


Arg Leu Ser Asp Gly Leu Val Pro Ser Gln Gly Asn Ile Glu His Ser 
145                 150                 155                 160 


Ala Asp Gly Pro Pro Val Val Thr Ala Glu Asp Ala Ser Leu Glu Asp 
                165                 170                 175     


Ser Lys Leu Glu Asp Ser Val Pro Leu Thr Glu Met Pro Glu Ala Val 
            180                 185                 190         


Asp Val Asp Glu Ser Gln Leu Glu Asn Val Cys Leu Ser Trp Gln Asn 
        195                 200                 205             


Glu Thr Ser Ser Gly Asn Leu Glu Ser 
    210                 215         


<210>  101
<211>  201
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 18

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  101

Xaa Glu Asp Ala Met Thr Gly Asp Thr Asp Lys Tyr Leu Gly Pro Gln 
1               5                   10                  15      


Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ala Glu Gly Tyr Met 
            20                  25                  30          


Gly Phe Ser Leu Gly Ala Arg Ser Ala Ser Pro Lys Ile Ser Leu Arg 
        35                  40                  45              


Ser Phe Ser Ser Asp Arg Ser Tyr Thr Leu Asn Arg Ser Ser Tyr Ala 
    50                  55                  60                  


Arg Asp Ser Met Met Ile Glu Glu Leu Leu Val Pro Ser Lys Glu Gln 
65                  70                  75                  80  


His Leu Thr Phe Thr Arg Glu Phe Asp Ser Asp Ser Leu Arg His Tyr 
                85                  90                  95      


Ser Trp Ala Ala Asp Thr Leu Asp Asn Val Asn Leu Val Ser Ser Pro 
            100                 105                 110         


Ile His Ser Gly Tyr Ser Ser Pro Leu Pro Gln Tyr Asp Ser Arg Phe 
        115                 120                 125             


Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg Gly Ser 
    130                 135                 140                 


Arg His His Gly Met Arg Ile Ile Ile Pro Pro Arg Lys Cys Thr Ala 
145                 150                 155                 160 


Pro Thr Arg Ile Thr Cys Arg Leu Val Lys Arg His Lys Leu Ala Asn 
                165                 170                 175     


Pro Pro Pro Met Val Glu Gly Glu Gly Leu Ala Ser Arg Leu Val Glu 
            180                 185                 190         


Met Gly Pro Ala Gly Ala Gln Phe Leu 
        195                 200     


<210>  102
<211>  196
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 19

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  102

Xaa Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp 
1               5                   10                  15      


Ala Arg Gly Gly Ser Met Arg Gly Ser Arg His His Gly Met Arg Ile 
            20                  25                  30          


Ile Ile Pro Pro Arg Lys Cys Thr Ala Pro Thr Arg Ile Thr Cys Arg 
        35                  40                  45              


Leu Val Lys Arg His Lys Leu Ala Asn Pro Pro Pro Met Val Glu Gly 
    50                  55                  60                  


Glu Gly Leu Ala Ser Arg Leu Val Glu Met Gly Pro Ala Gly Ala Gln 
65                  70                  75                  80  


Phe Leu Gly Lys Leu His Leu Pro Thr Asn Pro Pro Pro Val Asn Glu 
                85                  90                  95      


Gly Glu Ser Leu Val Ser Arg Ile Leu Gln Leu Gly Pro Gln Gly Thr 
            100                 105                 110         


Lys Phe Ile Gly Pro Val Ile Val Glu Ile Pro His Phe Gly Ser Met 
        115                 120                 125             


Arg Gly Lys Glu Arg Glu Leu Ile Val Leu Arg Ser Glu Asn Gly Glu 
    130                 135                 140                 


Thr Trp Lys Glu His Gln Phe Asp Ser Lys Asn Glu Asp Leu Thr Glu 
145                 150                 155                 160 


Leu Leu Asn Gly Met Asp Glu Glu Leu Asp Ser Pro Glu Glu Leu Gly 
                165                 170                 175     


Lys Lys Arg Ile Cys Arg Ile Ile Thr Lys Asp Phe Pro Gln Tyr Phe 
            180                 185                 190         


Ala Val Val Ser 
        195     


<210>  103
<211>  72
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 20

<400>  103

Met Thr Gly Asp Thr Asp Lys Tyr Leu Gly Pro Gln Asp Leu Lys Glu 
1               5                   10                  15      


Leu Gly Asp Asp Ser Leu Pro Ala Glu Gly Tyr Met Gly Phe Ser Leu 
            20                  25                  30          


Gly Ala Arg Ser Ala Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser Tyr 
        35                  40                  45              


Thr Leu Asn Arg Ser Ser Tyr Ala Arg Asp Ser Met Met Ile Glu Glu 
    50                  55                  60                  


Leu Leu Val Pro Ser Lys Glu Gln 
65                  70          


<210>  104
<211>  187
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 21

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  104

Xaa Ile Glu Lys Thr Asp Arg Arg Gln Ser Phe Ala Ser Leu Ala Leu 
1               5                   10                  15      


Arg Lys Arg Tyr Ser Tyr Leu Thr Glu Pro Gly Met Ser Pro Gln Ser 
            20                  25                  30          


Pro Cys Glu Arg Thr Asp Ile Arg Met Ala Ile Val Ala Asp His Leu 
        35                  40                  45              


Gly Leu Ser Trp Thr Glu Leu Ala Arg Glu Leu Asn Phe Ser Val Asp 
    50                  55                  60                  


Glu Ile Asn Gln Ile Arg Val Glu Asn Pro Asn Ser Leu Ile Ser Gln 
65                  70                  75                  80  


Ser Phe Met Leu Leu Lys Lys Trp Val Thr Arg Asp Gly Lys Asn Ala 
                85                  90                  95      


Thr Thr Asp Ala Leu Thr Ser Val Leu Thr Lys Ile Asn Arg Ile Asp 
            100                 105                 110         


Ile Val Thr Leu Leu Glu Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser 
        115                 120                 125             


Gly Thr Arg Ser Phe Ala Asp Glu Asn Asn Val Phe His Asp Pro Val 
    130                 135                 140                 


Asp Asp Gly Pro Pro Val Val Thr Ala Glu Asp Ala Ser Leu Glu Asp 
145                 150                 155                 160 


Ser Lys Leu Glu Asp Ser Val Pro Leu Thr Glu Met Pro Glu Ala Val 
                165                 170                 175     


Asp Val Asp Glu Ser Gln Leu Glu Asn Val Cys 
            180                 185         


<210>  105
<211>  175
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3ariant 22

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  105

Xaa Ser Pro Leu Ala Ala Tyr Gln Lys Ser Leu Glu Glu Thr Ser Lys 
1               5                   10                  15      


Leu Ile Ile Glu Glu Thr Lys Pro Cys Val Pro Val Ser Met Lys Lys 
            20                  25                  30          


Met Ser Arg Thr Ser Pro Ala Asp Gly Lys Pro Arg Leu Ser Leu His 
        35                  40                  45              


Glu Glu Glu Gly Ser Ser Gly Ser Glu Gln Lys Val Lys Ser Pro Gly 
    50                  55                  60                  


Ala Ala Pro Thr Arg Met Thr Ala Cys Cys Tyr Lys Asp Leu Lys Asp 
65                  70                  75                  80  


Ser Glu Ser Asp Ser Ser Ser Glu Glu Glu Arg Arg Val Thr Thr Arg 
                85                  90                  95      


Val Ile Arg Arg Arg Leu Ile Ile Lys Gly Glu Glu Ala Lys Asn Ile 
            100                 105                 110         


Pro Gly Glu Ser Val Thr Glu Glu Gln Phe Thr Asp Glu Glu Gly Asn 
        115                 120                 125             


Leu Ile Thr Arg Lys Ile Thr Arg Lys Val Leu Arg Arg Ile Val Ile 
    130                 135                 140                 


Pro Gln Glu Arg Lys Arg Asp Asp Val Gln Gly Glu Gly Phe Lys Val 
145                 150                 155                 160 


Lys Thr Lys Lys Glu Ile Arg His Val Glu Lys Lys Ser His Ser 
                165                 170                 175 


<210>  106
<211>  159
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 23

<400>  106

Met Thr Gly Asp Thr Asp Lys Tyr Leu Gly Pro Gln Asp Leu Lys Glu 
1               5                   10                  15      


Leu Gly Asp Asp Ser Leu Pro Ala Glu Gly Tyr Met Gly Phe Ser Leu 
            20                  25                  30          


Gly Ala Arg Ser Ala Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser Tyr 
        35                  40                  45              


Thr Leu Asn Arg Ser Ser Tyr Ala Arg Asp Ser Met Met Ile Glu Glu 
    50                  55                  60                  


Leu Leu Val Pro Ser Lys Glu Gln His Leu Thr Phe Thr Arg Glu Phe 
65                  70                  75                  80  


Asp Ser Asp Ser Leu Arg His Tyr Ser Trp Ala Ala Asp Thr Leu Asp 
                85                  90                  95      


Asn Val Asn Leu Val Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser 
            100                 105                 110         


Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg Gly Ser Arg His His 
        115                 120                 125             


Gly Met Arg Ile Ile Ile Pro Pro Arg Lys Cys Thr Ala Pro Thr Arg 
    130                 135                 140                 


Ile Thr Cys Arg Leu Val Lys Arg His Lys Leu Ala Asn Pro Pro 
145                 150                 155                 


<210>  107
<211>  63
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ankyrin-3 Variant 24

<400>  107

Met Thr Gly Asp Thr Asp Lys Tyr Leu Gly Pro Gln Asp Leu Lys Glu 
1               5                   10                  15      


Leu Gly Asp Asp Ser Leu Pro Ala Glu Gly Tyr Met Gly Phe Ser Leu 
            20                  25                  30          


Gly Ala Arg Ser Ala Ser His Ala Ala Ser Thr Val Ala Lys Glu Leu 
        35                  40                  45              


Thr Asp Lys Thr Gly Arg Thr Asn Leu Ser His Ile Phe Gln Asn 
    50                  55                  60              


<210>  108
<211>  1738
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Rho GTPase-activating protein 32 Variant 2

<400>  108

Met Lys Ser Arg Pro Thr Lys Gln Lys Leu Lys Gln Arg Gly Ile Leu 
1               5                   10                  15      


Lys Glu Arg Val Phe Gly Cys Asp Leu Gly Glu His Leu Leu Asn Ser 
            20                  25                  30          


Gly Phe Glu Val Pro Gln Val Leu Gln Ser Cys Thr Ala Phe Ile Glu 
        35                  40                  45              


Arg Tyr Gly Ile Val Asp Gly Ile Tyr Arg Leu Ser Gly Val Ala Ser 
    50                  55                  60                  


Asn Ile Gln Arg Leu Arg His Glu Phe Asp Ser Glu His Val Pro Asp 
65                  70                  75                  80  


Leu Thr Lys Glu Pro Tyr Val Gln Asp Ile His Ser Val Gly Ser Leu 
                85                  90                  95      


Cys Lys Leu Tyr Phe Arg Glu Leu Pro Asn Pro Leu Leu Thr Tyr Gln 
            100                 105                 110         


Leu Tyr Glu Lys Phe Ser Asp Ala Val Ser Ala Ala Thr Asp Glu Glu 
        115                 120                 125             


Arg Leu Ile Lys Ile His Asp Val Ile Gln Gln Leu Pro Pro Pro His 
    130                 135                 140                 


Tyr Arg Thr Leu Glu Phe Leu Met Arg His Leu Ser Leu Leu Ala Asp 
145                 150                 155                 160 


Tyr Cys Ser Ile Thr Asn Met His Ala Lys Asn Leu Ala Ile Val Trp 
                165                 170                 175     


Ala Pro Asn Leu Leu Arg Ser Lys Gln Ile Glu Ser Ala Cys Phe Ser 
            180                 185                 190         


Gly Thr Ala Ala Phe Met Glu Val Arg Ile Gln Ser Val Val Val Glu 
        195                 200                 205             


Phe Ile Leu Asn His Val Asp Val Leu Phe Ser Gly Arg Ile Ser Met 
    210                 215                 220                 


Ala Met Gln Glu Gly Ala Ala Ser Leu Ser Arg Pro Lys Ser Leu Leu 
225                 230                 235                 240 


Val Ser Ser Pro Ser Thr Lys Leu Leu Thr Leu Glu Glu Ala Gln Ala 
                245                 250                 255     


Arg Thr Gln Ala Gln Val Asn Ser Pro Ile Val Thr Glu Asn Lys Tyr 
            260                 265                 270         


Ile Glu Val Gly Glu Gly Pro Ala Ala Leu Gln Gly Lys Phe His Thr 
        275                 280                 285             


Ile Ile Glu Phe Pro Leu Glu Arg Lys Arg Pro Gln Asn Lys Met Lys 
    290                 295                 300                 


Lys Ser Pro Val Gly Ser Trp Arg Ser Phe Phe Asn Leu Gly Lys Ser 
305                 310                 315                 320 


Ser Ser Val Ser Lys Arg Lys Leu Gln Arg Asn Glu Ser Glu Pro Ser 
                325                 330                 335     


Glu Met Lys Ala Met Ala Leu Lys Gly Gly Arg Ala Glu Gly Thr Leu 
            340                 345                 350         


Arg Ser Ala Lys Ser Glu Glu Ser Leu Thr Ser Leu His Ala Val Asp 
        355                 360                 365             


Gly Asp Ser Lys Leu Phe Arg Pro Arg Arg Pro Arg Ser Ser Ser Asp 
    370                 375                 380                 


Ala Leu Ser Ala Ser Phe Asn Gly Glu Met Leu Gly Asn Arg Cys Asn 
385                 390                 395                 400 


Ser Tyr Asp Asn Leu Pro His Asp Asn Glu Ser Glu Glu Glu Gly Gly 
                405                 410                 415     


Leu Leu His Ile Pro Ala Leu Met Ser Pro His Ser Ala Glu Asp Val 
            420                 425                 430         


Asp Leu Ser Pro Pro Asp Ile Gly Val Ala Ser Leu Asp Phe Asp Pro 
        435                 440                 445             


Met Ser Phe Gln Cys Ser Pro Pro Lys Ala Glu Ser Glu Cys Leu Glu 
    450                 455                 460                 


Ser Gly Ala Ser Phe Leu Asp Ser Pro Gly Tyr Ser Lys Asp Lys Pro 
465                 470                 475                 480 


Ser Ala Asn Lys Lys Asp Ala Glu Thr Gly Ser Ser Gln Cys Gln Thr 
                485                 490                 495     


Pro Gly Ser Thr Ala Ser Ser Glu Pro Val Ser Pro Leu Gln Glu Lys 
            500                 505                 510         


Leu Ser Pro Phe Phe Thr Leu Asp Leu Ser Pro Thr Glu Asp Lys Ser 
        515                 520                 525             


Ser Lys Pro Ser Ser Phe Thr Glu Lys Val Val Tyr Ala Phe Ser Pro 
    530                 535                 540                 


Lys Ile Gly Arg Lys Leu Ser Lys Ser Pro Ser Met Ser Ile Ser Glu 
545                 550                 555                 560 


Pro Ile Ser Val Thr Leu Pro Pro Arg Val Ser Glu Val Ile Gly Thr 
                565                 570                 575     


Val Ser Asn Thr Thr Ala Gln Asn Ala Ser Ser Ser Thr Trp Asp Lys 
            580                 585                 590         


Cys Val Glu Glu Arg Asp Ala Thr Asn Arg Ser Pro Thr Gln Ile Val 
        595                 600                 605             


Lys Met Lys Thr Asn Glu Thr Val Ala Gln Glu Ala Tyr Glu Ser Glu 
    610                 615                 620                 


Val Gln Pro Leu Asp Gln Val Ala Ala Glu Glu Val Glu Leu Pro Gly 
625                 630                 635                 640 


Lys Glu Asp Gln Ser Val Ser Ser Ser Gln Ser Lys Ala Val Ala Ser 
                645                 650                 655     


Gly Gln Thr Gln Thr Gly Ala Val Thr His Asp Pro Pro Gln Asp Ser 
            660                 665                 670         


Val Pro Val Ser Ser Val Ser Leu Ile Pro Pro Pro Pro Pro Pro Lys 
        675                 680                 685             


Asn Val Ala Arg Met Leu Ala Leu Ala Leu Ala Glu Ser Ala Gln Gln 
    690                 695                 700                 


Ala Ser Thr Gln Ser Leu Lys Arg Pro Gly Thr Ser Gln Ala Gly Tyr 
705                 710                 715                 720 


Thr Asn Tyr Gly Asp Ile Ala Val Ala Thr Thr Glu Asp Asn Leu Ser 
                725                 730                 735     


Ser Ser Tyr Ser Ala Val Ala Leu Asp Lys Ala Tyr Phe Gln Thr Asp 
            740                 745                 750         


Arg Pro Ala Glu Gln Phe His Leu Gln Asn Asn Ala Pro Gly Asn Cys 
        755                 760                 765             


Asp His Pro Leu Pro Glu Thr Thr Ala Thr Gly Asp Pro Thr His Ser 
    770                 775                 780                 


Asn Thr Thr Glu Ser Gly Glu Gln His His Gln Val Asp Leu Thr Gly 
785                 790                 795                 800 


Asn Gln Pro His Gln Ala Tyr Leu Ser Gly Asp Pro Glu Lys Ala Arg 
                805                 810                 815     


Ile Thr Ser Val Pro Leu Asp Ser Glu Lys Ser Asp Asp His Val Ser 
            820                 825                 830         


Phe Pro Glu Asp Gln Ser Gly Lys Asn Ser Met Pro Thr Val Ser Phe 
        835                 840                 845             


Leu Asp Gln Asp Gln Ser Pro Pro Arg Phe Tyr Ser Gly Asp Gln Pro 
    850                 855                 860                 


Pro Ser Tyr Leu Gly Ala Ser Val Asp Lys Leu His His Pro Leu Glu 
865                 870                 875                 880 


Phe Ala Asp Lys Ser Pro Thr Pro Pro Asn Leu Pro Ser Asp Lys Ile 
                885                 890                 895     


Tyr Pro Pro Ser Gly Ser Pro Glu Glu Asn Thr Ser Thr Ala Thr Met 
            900                 905                 910         


Thr Tyr Met Thr Thr Thr Pro Ala Thr Ala Gln Met Ser Thr Lys Glu 
        915                 920                 925             


Ala Ser Trp Asp Val Ala Glu Gln Pro Thr Thr Ala Asp Phe Ala Ala 
    930                 935                 940                 


Ala Thr Leu Gln Arg Thr His Arg Thr Asn Arg Pro Leu Pro Pro Pro 
945                 950                 955                 960 


Pro Ser Gln Arg Ser Ala Glu Gln Pro Pro Val Val Gly Gln Val Gln 
                965                 970                 975     


Ala Ala Thr Asn Ile Gly Leu Asn Asn Ser His Lys Val Gln Gly Val 
            980                 985                 990         


Val Pro Val Pro Glu Arg Pro Pro  Glu Pro Arg Ala Met  Asp Asp Pro 
        995                 1000                 1005             


Ala Ser  Ala Phe Ile Ser Asp  Ser Gly Ala Ala Ala  Ala Gln Cys 
    1010                 1015                 1020             


Pro Met  Ala Thr Ala Val Gln  Pro Gly Leu Pro Glu  Lys Val Arg 
    1025                 1030                 1035             


Asp Gly  Ala Arg Val Pro Leu  Leu His Leu Arg Ala  Glu Ser Val 
    1040                 1045                 1050             


Pro Ala  His Pro Cys Gly Phe  Pro Ala Pro Leu Pro  Pro Thr Arg 
    1055                 1060                 1065             


Met Met  Glu Ser Lys Met Ile  Ala Ala Ile His Ser  Ser Ser Ala 
    1070                 1075                 1080             


Asp Ala  Thr Ser Ser Ser Asn  Tyr His Ser Phe Val  Thr Ala Ser 
    1085                 1090                 1095             


Ser Thr  Ser Val Asp Asp Ala  Leu Pro Leu Pro Leu  Pro Val Pro 
    1100                 1105                 1110             


Gln Pro  Lys His Ala Ser Gln  Lys Thr Val Tyr Ser  Ser Phe Ala 
    1115                 1120                 1125             


Arg Pro  Asp Val Thr Thr Glu  Pro Phe Gly Pro Asp  Asn Cys Leu 
    1130                 1135                 1140             


His Phe  Asn Met Thr Pro Asn  Cys Gln Tyr Arg Pro  Gln Ser Val 
    1145                 1150                 1155             


Pro Pro  His His Asn Lys Leu  Glu Gln His Gln Val  Tyr Gly Ala 
    1160                 1165                 1170             


Arg Ser  Glu Pro Pro Ala Ser  Met Gly Leu Arg Tyr  Asn Thr Tyr 
    1175                 1180                 1185             


Val Ala  Pro Gly Arg Asn Ala  Ser Gly His His Ser  Lys Pro Cys 
    1190                 1195                 1200             


Ser Arg  Val Glu Tyr Val Ser  Ser Leu Ser Ser Ser  Val Arg Asn 
    1205                 1210                 1215             


Thr Cys  Tyr Pro Glu Asp Ile  Pro Pro Tyr Pro Thr  Ile Arg Arg 
    1220                 1225                 1230             


Val Gln  Ser Leu His Ala Pro  Pro Ser Ser Met Ile  Arg Ser Val 
    1235                 1240                 1245             


Pro Ile  Ser Arg Thr Glu Val  Pro Pro Asp Asp Glu  Pro Ala Tyr 
    1250                 1255                 1260             


Cys Pro  Arg Pro Leu Tyr Gln  Tyr Lys Pro Tyr Gln  Ser Ser Gln 
    1265                 1270                 1275             


Ala Arg  Ser Asp Tyr His Val  Thr Gln Leu Gln Pro  Tyr Phe Glu 
    1280                 1285                 1290             


Asn Gly  Arg Val His Tyr Arg  Tyr Ser Pro Tyr Ser  Ser Ser Ser 
    1295                 1300                 1305             


Ser Ser  Tyr Tyr Ser Pro Asp  Gly Ala Leu Cys Asp  Val Asp Ala 
    1310                 1315                 1320             


Tyr Gly  Thr Val Gln Leu Arg  Pro Leu His Arg Leu  Pro Asn Arg 
    1325                 1330                 1335             


Asp Phe  Ala Phe Tyr Asn Pro  Arg Leu Gln Gly Lys  Ser Leu Tyr 
    1340                 1345                 1350             


Ser Tyr  Ala Gly Leu Ala Pro  Arg Pro Arg Ala Asn  Val Thr Gly 
    1355                 1360                 1365             


Tyr Phe  Ser Pro Asn Asp His  Asn Val Val Ser Met  Pro Pro Ala 
    1370                 1375                 1380             


Ala Asp  Val Lys His Thr Tyr  Thr Ser Trp Asp Leu  Glu Asp Met 
    1385                 1390                 1395             


Glu Lys  Tyr Arg Met Gln Ser  Ile Arg Arg Glu Ser  Arg Ala Arg 
    1400                 1405                 1410             


Gln Lys  Val Lys Gly Pro Val  Met Ser Gln Tyr Asp  Asn Met Thr 
    1415                 1420                 1425             


Pro Ala  Val Gln Asp Asp Leu  Gly Gly Ile Tyr Val  Ile His Leu 
    1430                 1435                 1440             


Arg Ser  Lys Ser Asp Pro Gly  Lys Thr Gly Leu Leu  Ser Val Ala 
    1445                 1450                 1455             


Glu Gly  Lys Glu Ser Arg His  Ala Ala Lys Ala Ile  Ser Pro Glu 
    1460                 1465                 1470             


Gly Glu  Asp Arg Phe Tyr Arg  Arg His Pro Glu Ala  Glu Met Asp 
    1475                 1480                 1485             


Arg Ala  His His His Gly Gly  His Gly Ser Thr Gln  Pro Glu Lys 
    1490                 1495                 1500             


Pro Ser  Leu Pro Gln Lys Gln  Ser Ser Leu Arg Ser  Arg Lys Leu 
    1505                 1510                 1515             


Pro Asp  Met Gly Cys Ser Leu  Pro Glu His Arg Ala  His Gln Glu 
    1520                 1525                 1530             


Ala Ser  His Arg Gln Phe Cys  Glu Ser Lys Asn Gly  Pro Pro Tyr 
    1535                 1540                 1545             


Pro Gln  Gly Ala Gly Gln Leu  Asp Tyr Gly Ser Lys  Gly Ile Pro 
    1550                 1555                 1560             


Asp Thr  Ser Glu Pro Val Ser  Tyr His Asn Ser Gly  Val Lys Tyr 
    1565                 1570                 1575             


Ala Ala  Ser Gly Gln Glu Ser  Leu Arg Leu Asn His  Lys Glu Val 
    1580                 1585                 1590             


Arg Leu  Ser Lys Glu Met Glu  Arg Pro Trp Val Arg  Gln Pro Ser 
    1595                 1600                 1605             


Ala Pro  Glu Lys His Ser Arg  Asp Cys Tyr Lys Glu  Glu Glu His 
    1610                 1615                 1620             


Leu Thr  Gln Ser Ile Val Pro  Pro Pro Lys Pro Glu  Arg Ser His 
    1625                 1630                 1635             


Ser Leu  Lys Leu His His Thr  Gln Asn Val Glu Arg  Asp Pro Ser 
    1640                 1645                 1650             


Val Leu  Tyr Gln Tyr Gln Pro  His Gly Lys Arg Gln  Ser Ser Val 
    1655                 1660                 1665             


Thr Val  Val Ser Gln Tyr Asp  Asn Leu Glu Asp Tyr  His Ser Leu 
    1670                 1675                 1680             


Pro Gln  His Gln Arg Gly Val  Phe Gly Gly Gly Gly  Met Gly Thr 
    1685                 1690                 1695             


Tyr Val  Pro Pro Gly Phe Pro  His Pro Gln Ser Arg  Thr Tyr Ala 
    1700                 1705                 1710             


Thr Ala  Leu Gly Gln Gly Ala  Phe Leu Pro Ala Glu  Leu Ser Leu 
    1715                 1720                 1725             


Gln His  Pro Glu Thr Gln Ile  His Ala Glu 
    1730                 1735             


<210>  109
<211>  1738
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Rho GTPase-activating protein 32 Variant 3

<400>  109

Met Lys Ser Arg Pro Thr Lys Gln Lys Leu Lys Gln Arg Gly Ile Leu 
1               5                   10                  15      


Lys Glu Arg Val Phe Gly Cys Asp Leu Gly Glu His Leu Leu Asn Ser 
            20                  25                  30          


Gly Phe Glu Val Pro Gln Val Leu Gln Ser Cys Thr Ala Phe Ile Glu 
        35                  40                  45              


Arg Tyr Gly Ile Val Asp Gly Ile Tyr Arg Leu Ser Gly Val Ala Ser 
    50                  55                  60                  


Asn Ile Gln Arg Leu Arg His Glu Phe Asp Ser Glu His Val Pro Asp 
65                  70                  75                  80  


Leu Thr Lys Glu Pro Tyr Val Gln Asp Ile His Ser Val Gly Ser Leu 
                85                  90                  95      


Cys Lys Leu Tyr Phe Arg Glu Leu Pro Asn Pro Leu Leu Thr Tyr Gln 
            100                 105                 110         


Leu Tyr Glu Lys Phe Ser Asp Ala Val Ser Ala Ala Thr Asp Glu Glu 
        115                 120                 125             


Arg Leu Ile Lys Ile His Asp Val Ile Gln Gln Leu Pro Pro Pro His 
    130                 135                 140                 


Tyr Arg Thr Leu Glu Phe Leu Met Arg His Leu Ser Leu Leu Ala Asp 
145                 150                 155                 160 


Tyr Cys Ser Ile Thr Asn Met His Ala Lys Asn Leu Ala Ile Val Trp 
                165                 170                 175     


Ala Pro Asn Leu Leu Arg Ser Lys Gln Ile Glu Ser Ala Cys Phe Ser 
            180                 185                 190         


Gly Thr Ala Ala Phe Met Glu Val Arg Ile Gln Ser Val Val Val Glu 
        195                 200                 205             


Phe Ile Leu Asn His Val Asp Val Leu Phe Ser Gly Arg Ile Ser Met 
    210                 215                 220                 


Ala Met Gln Glu Gly Ala Ala Ser Leu Ser Arg Pro Lys Ser Leu Leu 
225                 230                 235                 240 


Val Ser Ser Pro Ser Thr Lys Leu Leu Thr Leu Glu Glu Ala Gln Ala 
                245                 250                 255     


Arg Thr Gln Ala Gln Val Asn Ser Pro Ile Val Thr Glu Asn Lys Tyr 
            260                 265                 270         


Ile Glu Val Gly Glu Gly Pro Ala Ala Leu Gln Gly Lys Phe His Thr 
        275                 280                 285             


Ile Ile Glu Phe Pro Leu Glu Arg Lys Arg Pro Gln Asn Lys Met Lys 
    290                 295                 300                 


Lys Ser Pro Val Gly Ser Trp Arg Ser Phe Phe Asn Leu Gly Lys Ser 
305                 310                 315                 320 


Ser Ser Val Ser Lys Arg Lys Leu Gln Arg Asn Glu Ser Glu Pro Ser 
                325                 330                 335     


Glu Met Lys Ala Met Ala Leu Lys Gly Gly Arg Ala Glu Gly Thr Leu 
            340                 345                 350         


Arg Ser Ala Lys Ser Glu Glu Ser Leu Thr Ser Leu His Ala Val Asp 
        355                 360                 365             


Gly Asp Ser Lys Leu Phe Arg Pro Arg Arg Pro Arg Ser Ser Ser Asp 
    370                 375                 380                 


Ala Leu Ser Ala Ser Phe Asn Gly Glu Met Leu Gly Asn Arg Cys Asn 
385                 390                 395                 400 


Ser Tyr Asp Asn Leu Pro His Asp Asn Glu Ser Glu Glu Glu Gly Gly 
                405                 410                 415     


Leu Leu His Ile Pro Ala Leu Met Ser Pro His Ser Ala Glu Asp Val 
            420                 425                 430         


Asp Leu Ser Pro Pro Asp Ile Gly Val Ala Ser Leu Asp Phe Asp Pro 
        435                 440                 445             


Met Ser Phe Gln Cys Ser Pro Pro Lys Ala Glu Ser Glu Cys Leu Glu 
    450                 455                 460                 


Ser Gly Ala Ser Phe Leu Asp Ser Pro Gly Tyr Ser Lys Asp Lys Pro 
465                 470                 475                 480 


Ser Ala Asn Lys Lys Asp Ala Glu Thr Gly Ser Ser Gln Cys Gln Thr 
                485                 490                 495     


Pro Gly Ser Thr Ala Ser Ser Glu Pro Val Ser Pro Leu Gln Glu Lys 
            500                 505                 510         


Leu Ser Pro Phe Phe Thr Leu Asp Leu Ser Pro Thr Glu Asp Lys Ser 
        515                 520                 525             


Ser Lys Pro Ser Ser Phe Thr Glu Lys Val Val Tyr Ala Phe Ser Pro 
    530                 535                 540                 


Lys Ile Gly Arg Lys Leu Ser Lys Ser Pro Ser Met Ser Ile Ser Glu 
545                 550                 555                 560 


Pro Ile Ser Val Thr Leu Pro Pro Arg Val Ser Glu Val Ile Gly Thr 
                565                 570                 575     


Val Ser Asn Thr Thr Ala Gln Asn Ala Ser Ser Ser Thr Trp Asp Lys 
            580                 585                 590         


Cys Val Glu Glu Arg Asp Ala Thr Asn Arg Ser Pro Thr Gln Ile Val 
        595                 600                 605             


Lys Met Lys Thr Asn Glu Thr Val Ala Gln Glu Ala Tyr Glu Ser Glu 
    610                 615                 620                 


Val Gln Pro Leu Asp Gln Val Ala Ala Glu Glu Val Glu Leu Pro Gly 
625                 630                 635                 640 


Lys Glu Asp Gln Ser Val Ser Ser Ser Gln Ser Lys Ala Val Ala Ser 
                645                 650                 655     


Gly Gln Thr Gln Thr Gly Ala Val Thr His Asp Pro Pro Gln Asp Ser 
            660                 665                 670         


Val Pro Val Ser Ser Val Ser Leu Ile Pro Pro Pro Pro Pro Pro Lys 
        675                 680                 685             


Asn Val Ala Arg Met Leu Ala Leu Ala Leu Ala Glu Ser Ala Gln Gln 
    690                 695                 700                 


Ala Ser Thr Gln Ser Leu Lys Arg Pro Gly Thr Ser Gln Ala Gly Tyr 
705                 710                 715                 720 


Thr Asn Tyr Gly Asp Ile Ala Val Ala Thr Thr Glu Asp Asn Leu Ser 
                725                 730                 735     


Ser Ser Tyr Ser Ala Val Ala Leu Asp Lys Ala Tyr Phe Gln Thr Asp 
            740                 745                 750         


Arg Pro Ala Glu Gln Phe His Leu Gln Asn Asn Ala Pro Gly Asn Cys 
        755                 760                 765             


Asp His Pro Leu Pro Glu Thr Thr Ala Thr Gly Asp Pro Thr His Ser 
    770                 775                 780                 


Asn Thr Thr Glu Ser Gly Glu Gln His His Gln Val Asp Leu Thr Gly 
785                 790                 795                 800 


Asn Gln Pro His Gln Ala Tyr Leu Ser Gly Asp Pro Glu Lys Ala Arg 
                805                 810                 815     


Ile Thr Ser Val Pro Leu Asp Ser Glu Lys Ser Asp Asp His Val Ser 
            820                 825                 830         


Phe Pro Glu Asp Gln Ser Gly Lys Asn Ser Met Pro Thr Val Ser Phe 
        835                 840                 845             


Leu Asp Gln Asp Gln Ser Pro Pro Arg Phe Tyr Ser Gly Asp Gln Pro 
    850                 855                 860                 


Pro Ser Tyr Leu Gly Ala Ser Val Asp Lys Leu His His Pro Leu Glu 
865                 870                 875                 880 


Phe Ala Asp Lys Ser Pro Thr Pro Pro Asn Leu Pro Ser Asp Lys Ile 
                885                 890                 895     


Tyr Pro Pro Ser Gly Ser Pro Glu Glu Asn Thr Ser Thr Ala Thr Met 
            900                 905                 910         


Thr Tyr Met Thr Thr Thr Pro Ala Thr Ala Gln Met Ser Thr Lys Glu 
        915                 920                 925             


Ala Ser Trp Asp Val Ala Glu Gln Pro Thr Thr Ala Asp Phe Ala Ala 
    930                 935                 940                 


Ala Thr Leu Gln Arg Thr His Arg Thr Asn Arg Pro Leu Pro Pro Pro 
945                 950                 955                 960 


Pro Ser Gln Arg Ser Ala Glu Gln Pro Pro Val Val Gly Gln Val Gln 
                965                 970                 975     


Ala Ala Thr Asn Ile Gly Leu Asn Asn Ser His Lys Val Gln Gly Val 
            980                 985                 990         


Val Pro Val Pro Glu Arg Pro Pro  Glu Pro Arg Ala Met  Asp Asp Pro 
        995                 1000                 1005             


Ala Ser  Ala Phe Ile Ser Asp  Ser Gly Ala Ala Ala  Ala Gln Cys 
    1010                 1015                 1020             


Pro Met  Ala Thr Ala Val Gln  Pro Gly Leu Pro Glu  Lys Val Arg 
    1025                 1030                 1035             


Asp Gly  Ala Arg Val Pro Leu  Leu His Leu Arg Ala  Glu Ser Val 
    1040                 1045                 1050             


Pro Ala  His Pro Cys Gly Phe  Pro Ala Pro Leu Pro  Pro Thr Arg 
    1055                 1060                 1065             


Met Met  Glu Ser Lys Met Ile  Ala Ala Ile His Ser  Ser Ser Ala 
    1070                 1075                 1080             


Asp Ala  Thr Ser Ser Ser Asn  Tyr His Ser Phe Val  Thr Ala Ser 
    1085                 1090                 1095             


Ser Thr  Ser Val Asp Asp Ala  Leu Pro Leu Pro Leu  Pro Val Pro 
    1100                 1105                 1110             


Gln Pro  Lys His Ala Ser Gln  Lys Thr Val Tyr Ser  Ser Phe Ala 
    1115                 1120                 1125             


Arg Pro  Asp Val Thr Thr Glu  Pro Phe Gly Pro Asp  Asn Cys Leu 
    1130                 1135                 1140             


His Phe  Asn Met Thr Pro Asn  Cys Gln Tyr Arg Pro  Gln Ser Val 
    1145                 1150                 1155             


Pro Pro  His His Asn Lys Leu  Glu Gln His Gln Val  Tyr Gly Ala 
    1160                 1165                 1170             


Arg Ser  Glu Pro Pro Ala Ser  Met Gly Leu Arg Tyr  Asn Thr Tyr 
    1175                 1180                 1185             


Val Ala  Pro Gly Arg Asn Ala  Ser Gly His His Ser  Lys Pro Cys 
    1190                 1195                 1200             


Ser Arg  Val Glu Tyr Val Ser  Ser Leu Ser Ser Ser  Val Arg Asn 
    1205                 1210                 1215             


Thr Cys  Tyr Pro Glu Asp Ile  Pro Pro Tyr Pro Thr  Ile Arg Arg 
    1220                 1225                 1230             


Val Gln  Ser Leu His Ala Pro  Pro Ser Ser Met Ile  Arg Ser Val 
    1235                 1240                 1245             


Pro Ile  Ser Arg Thr Glu Val  Pro Pro Asp Asp Glu  Pro Ala Tyr 
    1250                 1255                 1260             


Cys Pro  Arg Pro Leu Tyr Gln  Tyr Lys Pro Tyr Gln  Ser Ser Gln 
    1265                 1270                 1275             


Ala Arg  Ser Asp Tyr His Val  Thr Gln Leu Gln Pro  Tyr Phe Glu 
    1280                 1285                 1290             


Asn Gly  Arg Val His Tyr Arg  Tyr Ser Pro Tyr Ser  Ser Ser Ser 
    1295                 1300                 1305             


Ser Ser  Tyr Tyr Ser Pro Asp  Gly Ala Leu Cys Asp  Val Asp Ala 
    1310                 1315                 1320             


Tyr Gly  Thr Val Gln Leu Arg  Pro Leu His Arg Leu  Pro Asn Arg 
    1325                 1330                 1335             


Asp Phe  Ala Phe Tyr Asn Pro  Arg Leu Gln Gly Lys  Ser Leu Tyr 
    1340                 1345                 1350             


Ser Tyr  Ala Gly Leu Ala Pro  Arg Pro Arg Ala Asn  Val Thr Gly 
    1355                 1360                 1365             


Tyr Phe  Ser Pro Asn Asp His  Asn Val Val Ser Met  Pro Pro Ala 
    1370                 1375                 1380             


Ala Asp  Val Lys His Thr Tyr  Thr Ser Trp Asp Leu  Glu Asp Met 
    1385                 1390                 1395             


Glu Lys  Tyr Arg Met Gln Ser  Ile Arg Arg Glu Ser  Arg Ala Arg 
    1400                 1405                 1410             


Gln Lys  Val Lys Gly Pro Val  Met Ser Gln Tyr Asp  Asn Met Thr 
    1415                 1420                 1425             


Pro Ala  Val Gln Asp Asp Leu  Gly Gly Ile Tyr Val  Ile His Leu 
    1430                 1435                 1440             


Arg Ser  Lys Ser Asp Pro Gly  Lys Thr Gly Leu Leu  Ser Val Ala 
    1445                 1450                 1455             


Glu Gly  Lys Glu Ser Arg His  Ala Ala Lys Ala Ile  Ser Pro Glu 
    1460                 1465                 1470             


Gly Glu  Asp Arg Phe Tyr Arg  Arg His Pro Glu Ala  Glu Met Asp 
    1475                 1480                 1485             


Arg Ala  His His His Gly Gly  His Gly Ser Thr Gln  Pro Glu Lys 
    1490                 1495                 1500             


Pro Ser  Leu Pro Gln Lys Gln  Ser Ser Leu Arg Ser  Arg Lys Leu 
    1505                 1510                 1515             


Pro Asp  Met Gly Cys Ser Leu  Pro Glu His Arg Ala  His Gln Glu 
    1520                 1525                 1530             


Ala Ser  His Arg Gln Phe Cys  Glu Ser Lys Asn Gly  Pro Pro Tyr 
    1535                 1540                 1545             


Pro Gln  Gly Ala Gly Gln Leu  Asp Tyr Gly Ser Lys  Gly Ile Pro 
    1550                 1555                 1560             


Asp Thr  Ser Glu Pro Val Ser  Tyr His Asn Ser Gly  Val Lys Tyr 
    1565                 1570                 1575             


Ala Ala  Ser Gly Gln Glu Ser  Leu Arg Leu Asn His  Lys Glu Val 
    1580                 1585                 1590             


Arg Leu  Ser Lys Glu Met Glu  Arg Pro Trp Val Arg  Gln Pro Ser 
    1595                 1600                 1605             


Ala Pro  Glu Lys His Ser Arg  Asp Cys Tyr Lys Glu  Glu Glu His 
    1610                 1615                 1620             


Leu Thr  Gln Ser Ile Val Pro  Pro Pro Lys Pro Glu  Arg Ser His 
    1625                 1630                 1635             


Ser Leu  Lys Leu His His Thr  Gln Asn Val Glu Arg  Asp Pro Ser 
    1640                 1645                 1650             


Val Leu  Tyr Gln Tyr Gln Pro  His Gly Lys Arg Gln  Ser Ser Val 
    1655                 1660                 1665             


Thr Val  Val Ser Gln Tyr Asp  Asn Leu Glu Asp Tyr  His Ser Leu 
    1670                 1675                 1680             


Pro Gln  His Gln Arg Gly Val  Phe Gly Gly Gly Gly  Met Gly Thr 
    1685                 1690                 1695             


Tyr Val  Pro Pro Gly Phe Pro  His Pro Gln Ser Arg  Thr Tyr Ala 
    1700                 1705                 1710             


Thr Ala  Leu Gly Gln Gly Ala  Phe Leu Pro Ala Glu  Leu Ser Leu 
    1715                 1720                 1725             


Gln His  Pro Glu Thr Gln Ile  His Ala Glu 
    1730                 1735             


<210>  110
<211>  946
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Rho GTPase-activating protein 32 Variant 4

<400>  110

Met Ala Arg Gly Ala Asp Val Pro Glu Ile Pro Gly Asp Leu Thr Leu 
1               5                   10                  15      


Lys Thr Cys Gly Ser Thr Ala Ser Met Lys Val Lys His Val Lys Lys 
            20                  25                  30          


Leu Pro Phe Thr Lys Gly His Phe Pro Lys Met Ala Glu Cys Ala His 
        35                  40                  45              


Phe His Tyr Glu Asn Val Glu Phe Gly Ser Ile Gln Leu Ser Leu Ser 
    50                  55                  60                  


Glu Glu Gln Asn Glu Val Met Lys Asn Gly Cys Glu Ser Lys Glu Leu 
65                  70                  75                  80  


Val Tyr Leu Val Gln Ile Ala Cys Gln Gly Lys Ser Trp Ile Val Lys 
                85                  90                  95      


Arg Ser Tyr Glu Asp Phe Arg Val Leu Asp Lys His Leu His Leu Cys 
            100                 105                 110         


Ile Tyr Asp Arg Arg Phe Ser Gln Leu Ser Glu Leu Pro Arg Ser Asp 
        115                 120                 125             


Thr Leu Lys Asp Ser Pro Glu Ser Val Thr Gln Met Leu Met Ala Tyr 
    130                 135                 140                 


Leu Ser Arg Leu Ser Ala Ile Ala Gly Asn Lys Ile Asn Cys Gly Pro 
145                 150                 155                 160 


Ala Leu Thr Trp Met Glu Ile Asp Asn Lys Gly Asn His Leu Leu Val 
                165                 170                 175     


His Glu Glu Ser Ser Ile Asn Thr Pro Ala Val Gly Ala Ala His Val 
            180                 185                 190         


Ile Lys Arg Tyr Thr Ala Arg Ala Pro Asp Glu Leu Thr Leu Glu Val 
        195                 200                 205             


Gly Asp Ile Val Ser Val Ile Asp Met Pro Pro Lys Val Leu Ser Thr 
    210                 215                 220                 


Trp Trp Arg Gly Lys His Gly Phe Gln Val Gly Leu Phe Pro Gly His 
225                 230                 235                 240 


Cys Val Glu Leu Ile Asn Gln Lys Val Pro Gln Ser Val Thr Asn Ser 
                245                 250                 255     


Val Pro Lys Pro Val Ser Lys Lys His Gly Lys Leu Ile Thr Phe Leu 
            260                 265                 270         


Arg Thr Phe Met Lys Ser Arg Pro Thr Lys Gln Lys Leu Lys Gln Arg 
        275                 280                 285             


Gly Ile Leu Lys Glu Arg Val Phe Gly Cys Asp Leu Gly Glu His Leu 
    290                 295                 300                 


Leu Asn Ser Gly Phe Glu Val Pro Gln Val Leu Gln Ser Cys Thr Ala 
305                 310                 315                 320 


Phe Ile Glu Arg Tyr Gly Ile Val Asp Gly Ile Tyr Arg Leu Ser Gly 
                325                 330                 335     


Val Ala Ser Asn Ile Gln Arg Leu Arg His Glu Phe Asp Ser Glu His 
            340                 345                 350         


Val Pro Asp Leu Thr Lys Glu Pro Tyr Val Gln Asp Ile His Ser Val 
        355                 360                 365             


Gly Ser Leu Cys Lys Leu Tyr Phe Arg Glu Leu Pro Asn Pro Leu Leu 
    370                 375                 380                 


Thr Tyr Gln Leu Tyr Glu Lys Phe Ser Asp Ala Val Ser Ala Ala Thr 
385                 390                 395                 400 


Asp Glu Glu Arg Leu Ile Lys Ile His Asp Val Ile Gln Gln Leu Pro 
                405                 410                 415     


Pro Pro His Tyr Arg Thr Leu Glu Phe Leu Met Arg His Leu Ser Leu 
            420                 425                 430         


Leu Ala Asp Tyr Cys Ser Ile Thr Asn Met His Ala Lys Asn Leu Ala 
        435                 440                 445             


Ile Val Trp Ala Pro Asn Leu Leu Arg Ser Lys Gln Ile Glu Ser Ala 
    450                 455                 460                 


Cys Phe Ser Gly Thr Ala Ala Phe Met Glu Val Arg Ile Gln Ser Val 
465                 470                 475                 480 


Val Val Glu Phe Ile Leu Asn His Val Asp Val Leu Phe Ser Gly Arg 
                485                 490                 495     


Ile Ser Met Ala Met Gln Glu Gly Ala Ala Ser Leu Ser Arg Pro Lys 
            500                 505                 510         


Ser Leu Leu Val Ser Ser Pro Ser Thr Lys Leu Leu Thr Leu Glu Glu 
        515                 520                 525             


Ala Gln Ala Arg Thr Gln Ala Gln Val Asn Ser Pro Ile Val Thr Glu 
    530                 535                 540                 


Asn Lys Tyr Ile Glu Val Gly Glu Gly Pro Ala Ala Leu Gln Gly Lys 
545                 550                 555                 560 


Phe His Thr Ile Ile Glu Phe Pro Leu Glu Arg Lys Arg Pro Gln Asn 
                565                 570                 575     


Lys Met Lys Lys Ser Pro Val Gly Ser Trp Arg Ser Phe Phe Asn Leu 
            580                 585                 590         


Gly Lys Ser Ser Ser Val Ser Lys Arg Lys Leu Gln Arg Asn Glu Ser 
        595                 600                 605             


Glu Pro Ser Glu Met Lys Ala Met Ala Leu Lys Gly Gly Arg Ala Glu 
    610                 615                 620                 


Gly Thr Leu Arg Ser Ala Lys Ser Glu Glu Ser Leu Thr Ser Leu His 
625                 630                 635                 640 


Ala Val Asp Gly Asp Ser Lys Leu Phe Arg Pro Arg Arg Pro Arg Ser 
                645                 650                 655     


Ser Ser Asp Ala Leu Ser Ala Ser Phe Asn Gly Glu Met Leu Gly Asn 
            660                 665                 670         


Arg Cys Asn Ser Tyr Asp Asn Leu Pro His Asp Asn Glu Ser Glu Glu 
        675                 680                 685             


Glu Gly Gly Leu Leu His Ile Pro Ala Leu Met Ser Pro His Ser Ala 
    690                 695                 700                 


Glu Asp Val Asp Leu Ser Pro Pro Asp Ile Gly Val Ala Ser Leu Asp 
705                 710                 715                 720 


Phe Asp Pro Met Ser Phe Gln Cys Ser Pro Pro Lys Ala Glu Ser Glu 
                725                 730                 735     


Cys Leu Glu Ser Gly Ala Ser Phe Leu Asp Ser Pro Gly Tyr Ser Lys 
            740                 745                 750         


Asp Lys Pro Ser Ala Asn Lys Lys Asp Ala Glu Thr Gly Ser Ser Gln 
        755                 760                 765             


Cys Gln Thr Pro Gly Ser Thr Ala Ser Ser Glu Pro Val Ser Pro Leu 
    770                 775                 780                 


Gln Glu Lys Leu Ser Pro Phe Phe Thr Leu Asp Leu Ser Pro Thr Glu 
785                 790                 795                 800 


Asp Lys Ser Ser Lys Pro Ser Ser Phe Thr Glu Lys Val Val Tyr Ala 
                805                 810                 815     


Phe Ser Pro Lys Ile Gly Arg Lys Leu Ser Lys Ser Pro Ser Met Ser 
            820                 825                 830         


Ile Ser Glu Pro Ile Ser Val Thr Leu Pro Pro Arg Val Ser Glu Val 
        835                 840                 845             


Ile Gly Thr Val Ser Asn Thr Thr Ala Gln Asn Ala Ser Ser Ser Thr 
    850                 855                 860                 


Trp Asp Lys Cys Val Glu Glu Arg Asp Ala Thr Asn Arg Ser Pro Thr 
865                 870                 875                 880 


Gln Ile Val Lys Met Lys Thr Asn Glu Thr Val Ala Gln Glu Ala Tyr 
                885                 890                 895     


Glu Ser Glu Val Gln Pro Leu Asp Gln Val Ala Ala Glu Glu Val Glu 
            900                 905                 910         


Leu Pro Gly Lys Glu Asp Gln Ser Val Ser Ser Ser Gln Ser Lys Ala 
        915                 920                 925             


Val Ala Ser Gly Gln Thr Gln Thr Gly Thr Val Cys Phe Pro Pro Phe 
    930                 935                 940                 


Phe Leu 
945     


<210>  111
<211>  178
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Rho GTPase-activating protein 32 Variant 5

<400>  111

Met Lys Ser Ser Val His Ser Glu Glu Asp Asp Phe Val Pro Glu Leu 
1               5                   10                  15      


His Arg Asn Val His Pro Arg Glu Arg Pro Asp Trp Glu Glu Thr Leu 
            20                  25                  30          


Ser Ala Met Ala Arg Gly Ala Asp Val Pro Glu Ile Pro Gly Asp Leu 
        35                  40                  45              


Thr Leu Lys Thr Cys Gly Ser Thr Ala Ser Met Lys Val Lys His Val 
    50                  55                  60                  


Lys Lys Ser Thr Thr Pro Gly Leu Met Gly Cys Asp Asn Ile His Arg 
65                  70                  75                  80  


Leu Pro Phe Thr Lys Gly His Phe Pro Lys Met Ala Glu Cys Ala His 
                85                  90                  95      


Phe His Tyr Glu Asn Val Glu Phe Gly Ser Ile Gln Leu Ser Leu Ser 
            100                 105                 110         


Glu Glu Gln Asn Glu Val Met Lys Asn Gly Cys Glu Ser Lys Glu Leu 
        115                 120                 125             


Val Tyr Leu Val Gln Ile Ala Cys Gln Gly Lys Ser Trp Ile Val Lys 
    130                 135                 140                 


Arg Ser Tyr Glu Asp Phe Arg Val Leu Asp Lys His Leu His Leu Cys 
145                 150                 155                 160 


Ile Tyr Asp Arg Arg Phe Ser Gln Leu Ser Glu Leu Pro Arg Ser Asp 
                165                 170                 175     


Thr Leu 
        


<210>  112
<211>  410
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Cytoskeletal Keratin 78 type II Variant 2

<400>  112

Met Glu Gly His Glu Ala Ser Pro Ala Gln Val Gly Gln Gly Asp Arg 
1               5                   10                  15      


Gly Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Val Leu Glu Thr Lys 
            20                  25                  30          


Trp His Leu Leu Gln Gln Gln Gly Leu Ser Gly Ser Gln Gln Gly Leu 
        35                  40                  45              


Glu Pro Val Phe Glu Ala Cys Leu Asp Gln Leu Arg Lys Gln Leu Glu 
    50                  55                  60                  


Gln Leu Gln Gly Glu Arg Gly Ala Leu Asp Ala Glu Leu Lys Ala Cys 
65                  70                  75                  80  


Arg Asp Gln Glu Glu Glu Tyr Lys Ser Lys Tyr Glu Glu Glu Ala His 
                85                  90                  95      


Arg Arg Ala Thr Leu Glu Asn Asp Phe Val Val Leu Lys Lys Asp Val 
            100                 105                 110         


Asp Gly Val Phe Leu Ser Lys Met Glu Leu Glu Gly Lys Leu Glu Ala 
        115                 120                 125             


Leu Arg Glu Tyr Leu Tyr Phe Leu Lys His Leu Asn Glu Glu Glu Leu 
    130                 135                 140                 


Gly Gln Leu Gln Thr Gln Ala Ser Asp Thr Ser Val Val Leu Ser Met 
145                 150                 155                 160 


Asp Asn Asn Arg Tyr Leu Asp Phe Ser Ser Ile Ile Thr Glu Val Arg 
                165                 170                 175     


Ala Arg Tyr Glu Glu Ile Ala Arg Ser Ser Lys Ala Glu Ala Glu Ala 
            180                 185                 190         


Leu Tyr Gln Thr Lys Tyr Gln Glu Leu Gln Val Ser Ala Gln Leu His 
        195                 200                 205             


Gly Asp Arg Met Gln Glu Thr Lys Val Gln Ile Ser Gln Leu His Gln 
    210                 215                 220                 


Glu Ile Gln Arg Leu Gln Ser Gln Thr Glu Asn Leu Lys Lys Gln Asn 
225                 230                 235                 240 


Ala Ser Leu Gln Ala Ala Ile Thr Asp Ala Glu Gln Arg Gly Glu Leu 
                245                 250                 255     


Ala Leu Lys Asp Ala Gln Ala Lys Val Asp Glu Leu Glu Ala Ala Leu 
            260                 265                 270         


Arg Met Ala Lys Gln Asn Leu Ala Arg Leu Leu Cys Glu Tyr Gln Glu 
        275                 280                 285             


Leu Thr Ser Thr Lys Leu Ser Leu Asp Val Glu Ile Ala Thr Tyr Arg 
    290                 295                 300                 


Arg Leu Leu Glu Gly Glu Glu Cys Arg Met Ser Gly Glu Cys Thr Ser 
305                 310                 315                 320 


Gln Val Thr Ile Ser Ser Val Gly Gly Ser Ala Val Met Ser Gly Gly 
                325                 330                 335     


Val Gly Gly Gly Leu Gly Ser Thr Cys Gly Leu Gly Ser Gly Lys Gly 
            340                 345                 350         


Ser Pro Gly Ser Cys Cys Thr Ser Ile Val Thr Gly Gly Ser Asn Ile 
        355                 360                 365             


Ile Leu Gly Ser Gly Lys Asp Pro Val Leu Asp Ser Cys Ser Val Ser 
    370                 375                 380                 


Gly Ser Ser Ala Gly Ser Ser Cys His Thr Ile Leu Lys Lys Thr Val 
385                 390                 395                 400 


Glu Ser Ser Leu Lys Thr Ser Ile Thr Tyr 
                405                 410 


<210>  113
<211>  41
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Cytoskeletal Keratin 78 type II Variant 3

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  113

Xaa Asp Val Glu Ile Ala Thr Tyr Arg Arg Leu Leu Glu Gly Glu Glu 
1               5                   10                  15      


Cys Ser Leu Gly Gly Arg Gln Arg Cys His Val Trp Arg Ser Trp Trp 
            20                  25                  30          


Arg Leu Gly Glu His Leu Trp Thr Arg 
        35                  40      


<210>  114
<211>  2971
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Collagen type VI, alpha 3 Variant 2

<400>  114

Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe 
1               5                   10                  15      


Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Ala Gln 
            20                  25                  30          


Asp Ser Ala Asp Ile Ile Phe Leu Ile Asp Gly Ser Asn Asn Thr Gly 
        35                  40                  45              


Ser Val Asn Phe Ala Val Ile Leu Asp Phe Leu Val Asn Leu Leu Glu 
    50                  55                  60                  


Lys Leu Pro Ile Gly Thr Gln Gln Ile Arg Val Gly Val Val Gln Phe 
65                  70                  75                  80  


Ser Asp Glu Pro Arg Thr Met Phe Ser Leu Asp Thr Tyr Ser Thr Lys 
                85                  90                  95      


Ala Gln Val Leu Gly Ala Val Lys Ala Leu Gly Phe Ala Gly Gly Glu 
            100                 105                 110         


Leu Ala Asn Ile Gly Leu Ala Leu Asp Phe Val Val Glu Asn His Phe 
        115                 120                 125             


Thr Arg Ala Gly Gly Ser Arg Val Glu Glu Gly Val Pro Gln Val Leu 
    130                 135                 140                 


Val Leu Ile Ser Ala Gly Pro Ser Ser Asp Glu Ile Arg Tyr Gly Val 
145                 150                 155                 160 


Val Ala Leu Lys Gln Ala Ser Val Phe Ser Phe Gly Leu Gly Ala Gln 
                165                 170                 175     


Ala Ala Ser Arg Ala Glu Leu Gln His Ile Ala Thr Asp Asp Asn Leu 
            180                 185                 190         


Val Phe Thr Val Pro Glu Phe Arg Ser Phe Gly Asp Leu Gln Glu Lys 
        195                 200                 205             


Leu Leu Pro Tyr Ile Val Gly Val Ala Gln Arg His Ile Val Leu Lys 
    210                 215                 220                 


Pro Pro Thr Ile Val Thr Gln Val Ile Glu Val Asn Lys Arg Asp Ile 
225                 230                 235                 240 


Val Phe Leu Val Asp Gly Ser Ser Ala Leu Gly Leu Ala Asn Phe Asn 
                245                 250                 255     


Ala Ile Arg Asp Phe Ile Ala Lys Val Ile Gln Arg Leu Glu Ile Gly 
            260                 265                 270         


Gln Asp Leu Ile Gln Val Ala Val Ala Gln Tyr Ala Asp Thr Val Arg 
        275                 280                 285             


Pro Glu Phe Tyr Phe Asn Thr His Pro Thr Lys Arg Glu Val Ile Thr 
    290                 295                 300                 


Ala Val Arg Lys Met Lys Pro Leu Asp Gly Ser Ala Leu Tyr Thr Gly 
305                 310                 315                 320 


Ser Ala Leu Asp Phe Val Arg Asn Asn Leu Phe Thr Ser Ser Ala Gly 
                325                 330                 335     


Tyr Arg Ala Ala Glu Gly Ile Pro Lys Leu Leu Val Leu Ile Thr Gly 
            340                 345                 350         


Gly Lys Ser Leu Asp Glu Ile Ser Gln Pro Ala Gln Glu Leu Lys Arg 
        355                 360                 365             


Ser Ser Ile Met Ala Phe Ala Ile Gly Asn Lys Gly Ala Asp Gln Ala 
    370                 375                 380                 


Glu Leu Glu Glu Ile Ala Phe Asp Ser Ser Leu Val Phe Ile Pro Ala 
385                 390                 395                 400 


Glu Phe Arg Ala Ala Pro Leu Gln Gly Met Leu Pro Gly Leu Leu Ala 
                405                 410                 415     


Pro Leu Arg Thr Leu Ser Gly Thr Pro Glu Val His Ser Asn Lys Arg 
            420                 425                 430         


Asp Ile Ile Phe Leu Leu Asp Gly Ser Ala Asn Val Gly Lys Thr Asn 
        435                 440                 445             


Phe Pro Tyr Val Arg Asp Phe Val Met Asn Leu Val Asn Ser Leu Asp 
    450                 455                 460                 


Ile Gly Asn Asp Asn Ile Arg Val Gly Leu Val Gln Phe Ser Asp Thr 
465                 470                 475                 480 


Pro Val Thr Glu Phe Ser Leu Asn Thr Tyr Gln Thr Lys Ser Asp Ile 
                485                 490                 495     


Leu Gly His Leu Arg Gln Leu Gln Leu Gln Gly Gly Ser Gly Leu Asn 
            500                 505                 510         


Thr Gly Ser Ala Leu Ser Tyr Val Tyr Ala Asn His Phe Thr Glu Ala 
        515                 520                 525             


Gly Gly Ser Arg Ile Arg Glu His Val Pro Gln Leu Leu Leu Leu Leu 
    530                 535                 540                 


Thr Ala Gly Gln Ser Glu Asp Ser Tyr Leu Gln Ala Ala Asn Ala Leu 
545                 550                 555                 560 


Thr Arg Ala Gly Ile Leu Thr Phe Cys Val Gly Ala Ser Gln Ala Asn 
                565                 570                 575     


Lys Ala Glu Leu Glu Gln Ile Ala Phe Asn Pro Ser Leu Val Tyr Leu 
            580                 585                 590         


Met Asp Asp Phe Ser Ser Leu Pro Ala Leu Pro Gln Gln Leu Ile Gln 
        595                 600                 605             


Pro Leu Thr Thr Tyr Val Ser Gly Gly Val Glu Glu Val Pro Leu Ala 
    610                 615                 620                 


Gln Pro Glu Ser Lys Arg Asp Ile Leu Phe Leu Phe Asp Gly Ser Ala 
625                 630                 635                 640 


Asn Leu Val Gly Gln Phe Pro Val Val Arg Asp Phe Leu Tyr Lys Ile 
                645                 650                 655     


Ile Asp Glu Leu Asn Val Lys Pro Glu Gly Thr Arg Ile Ala Val Ala 
            660                 665                 670         


Gln Tyr Ser Asp Asp Val Lys Val Glu Ser Arg Phe Asp Glu His Gln 
        675                 680                 685             


Ser Lys Pro Glu Ile Leu Asn Leu Val Lys Arg Met Lys Ile Lys Thr 
    690                 695                 700                 


Gly Lys Ala Leu Asn Leu Gly Tyr Ala Leu Asp Tyr Ala Gln Arg Tyr 
705                 710                 715                 720 


Ile Phe Val Lys Ser Ala Gly Ser Arg Ile Glu Asp Gly Val Leu Gln 
                725                 730                 735     


Phe Leu Val Leu Leu Val Ala Gly Arg Ser Ser Asp Arg Val Asp Gly 
            740                 745                 750         


Pro Ala Ser Asn Leu Lys Gln Ser Gly Val Val Pro Phe Ile Phe Gln 
        755                 760                 765             


Ala Lys Asn Ala Asp Pro Ala Glu Leu Glu Gln Ile Val Leu Ser Pro 
    770                 775                 780                 


Ala Phe Ile Leu Ala Ala Glu Ser Leu Pro Lys Ile Gly Asp Leu His 
785                 790                 795                 800 


Pro Gln Ile Val Asn Leu Leu Lys Ser Val His Asn Gly Ala Pro Ala 
                805                 810                 815     


Pro Val Ser Gly Glu Lys Asp Val Val Phe Leu Leu Asp Gly Ser Glu 
            820                 825                 830         


Gly Val Arg Ser Gly Phe Pro Leu Leu Lys Glu Phe Val Gln Arg Val 
        835                 840                 845             


Val Glu Ser Leu Asp Val Gly Gln Asp Arg Val Arg Val Ala Val Val 
    850                 855                 860                 


Gln Tyr Ser Asp Arg Thr Arg Pro Glu Phe Tyr Leu Asn Ser Tyr Met 
865                 870                 875                 880 


Asn Lys Gln Asp Val Val Asn Ala Val Arg Gln Leu Thr Leu Leu Gly 
                885                 890                 895     


Gly Pro Thr Pro Asn Thr Gly Ala Ala Leu Glu Phe Val Leu Arg Asn 
            900                 905                 910         


Ile Leu Val Ser Ser Ala Gly Ser Arg Ile Thr Glu Gly Val Pro Gln 
        915                 920                 925             


Leu Leu Ile Val Leu Thr Ala Asp Arg Ser Gly Asp Asp Val Arg Asn 
    930                 935                 940                 


Pro Ser Val Val Val Lys Arg Gly Gly Ala Val Pro Ile Gly Ile Gly 
945                 950                 955                 960 


Ile Gly Asn Ala Asp Ile Thr Glu Met Gln Thr Ile Ser Phe Ile Pro 
                965                 970                 975     


Asp Phe Ala Val Ala Ile Pro Thr Phe Arg Gln Leu Gly Thr Val Gln 
            980                 985                 990         


Gln Val Ile Ser Glu Arg Val Thr  Gln Leu Thr Arg Glu  Glu Leu Ser 
        995                 1000                 1005             


Arg Leu  Gln Pro Val Leu Gln  Pro Leu Pro Ser Pro  Gly Val Gly 
    1010                 1015                 1020             


Gly Lys  Arg Asp Val Val Phe  Leu Ile Asp Gly Ser  Gln Ser Ala 
    1025                 1030                 1035             


Gly Pro  Glu Phe Gln Tyr Val  Arg Thr Leu Ile Glu  Arg Leu Val 
    1040                 1045                 1050             


Asp Tyr  Leu Asp Val Gly Phe  Asp Thr Thr Arg Val  Ala Val Ile 
    1055                 1060                 1065             


Gln Phe  Ser Asp Asp Pro Lys  Val Glu Phe Leu Leu  Asn Ala His 
    1070                 1075                 1080             


Ser Ser  Lys Asp Glu Val Gln  Asn Ala Val Gln Arg  Leu Arg Pro 
    1085                 1090                 1095             


Lys Gly  Gly Arg Gln Ile Asn  Val Gly Asn Ala Leu  Glu Tyr Val 
    1100                 1105                 1110             


Ser Arg  Asn Ile Phe Lys Arg  Pro Leu Gly Ser Arg  Ile Glu Glu 
    1115                 1120                 1125             


Gly Val  Pro Gln Phe Leu Val  Leu Ile Ser Ser Gly  Lys Ser Asp 
    1130                 1135                 1140             


Asp Glu  Val Asp Asp Pro Ala  Val Glu Leu Lys Gln  Phe Gly Val 
    1145                 1150                 1155             


Ala Pro  Phe Thr Ile Ala Arg  Asn Ala Asp Gln Glu  Glu Leu Val 
    1160                 1165                 1170             


Lys Ile  Ser Leu Ser Pro Glu  Tyr Val Phe Ser Val  Ser Thr Phe 
    1175                 1180                 1185             


Arg Glu  Leu Pro Ser Leu Glu  Gln Lys Leu Leu Thr  Pro Ile Thr 
    1190                 1195                 1200             


Thr Leu  Thr Ser Glu Gln Ile  Gln Lys Leu Leu Ala  Ser Thr Arg 
    1205                 1210                 1215             


Tyr Pro  Pro Pro Ala Val Glu  Ser Asp Ala Ala Asp  Ile Val Phe 
    1220                 1225                 1230             


Leu Ile  Asp Ser Ser Glu Gly  Val Arg Pro Asp Gly  Phe Ala His 
    1235                 1240                 1245             


Ile Arg  Asp Phe Val Ser Arg  Ile Val Arg Arg Leu  Asn Ile Gly 
    1250                 1255                 1260             


Pro Ser  Lys Val Arg Val Gly  Val Val Gln Phe Ser  Asn Asp Val 
    1265                 1270                 1275             


Phe Pro  Glu Phe Tyr Leu Lys  Thr Tyr Arg Ser Gln  Ala Pro Val 
    1280                 1285                 1290             


Leu Asp  Ala Ile Arg Arg Leu  Arg Leu Arg Gly Gly  Ser Pro Leu 
    1295                 1300                 1305             


Asn Thr  Gly Lys Ala Leu Glu  Phe Val Ala Arg Asn  Leu Phe Val 
    1310                 1315                 1320             


Lys Ser  Ala Gly Ser Arg Ile  Glu Asp Gly Val Pro  Gln His Leu 
    1325                 1330                 1335             


Val Leu  Val Leu Gly Gly Lys  Ser Gln Asp Asp Val  Ser Arg Phe 
    1340                 1345                 1350             


Ala Gln  Val Ile Arg Ser Ser  Gly Ile Val Ser Leu  Gly Val Gly 
    1355                 1360                 1365             


Asp Arg  Asn Ile Asp Arg Thr  Glu Leu Gln Thr Ile  Thr Asn Asp 
    1370                 1375                 1380             


Pro Arg  Leu Val Phe Thr Val  Arg Glu Phe Arg Glu  Leu Pro Asn 
    1385                 1390                 1395             


Ile Glu  Glu Arg Ile Met Asn  Ser Phe Gly Pro Ser  Ala Ala Thr 
    1400                 1405                 1410             


Pro Ala  Pro Pro Gly Val Asp  Thr Pro Pro Pro Ser  Arg Pro Glu 
    1415                 1420                 1425             


Lys Lys  Lys Ala Asp Ile Val  Phe Leu Leu Asp Gly  Ser Ile Asn 
    1430                 1435                 1440             


Phe Arg  Arg Asp Ser Phe Gln  Glu Val Leu Arg Phe  Val Ser Glu 
    1445                 1450                 1455             


Ile Val  Asp Thr Val Tyr Glu  Asp Gly Asp Ser Ile  Gln Val Gly 
    1460                 1465                 1470             


Leu Val  Gln Tyr Asn Ser Asp  Pro Thr Asp Glu Phe  Phe Leu Lys 
    1475                 1480                 1485             


Asp Phe  Ser Thr Lys Arg Gln  Ile Ile Asp Ala Ile  Asn Lys Val 
    1490                 1495                 1500             


Val Tyr  Lys Gly Gly Arg His  Ala Asn Thr Lys Val  Gly Leu Glu 
    1505                 1510                 1515             


His Leu  Arg Val Asn His Phe  Val Pro Glu Ala Gly  Ser Arg Leu 
    1520                 1525                 1530             


Asp Gln  Arg Val Pro Gln Ile  Ala Phe Val Ile Thr  Gly Gly Lys 
    1535                 1540                 1545             


Ser Val  Glu Asp Ala Gln Asp  Val Ser Leu Ala Leu  Thr Gln Arg 
    1550                 1555                 1560             


Gly Val  Lys Val Phe Ala Val  Gly Val Arg Asn Ile  Asp Ser Glu 
    1565                 1570                 1575             


Glu Val  Gly Lys Ile Ala Ser  Asn Ser Ala Thr Ala  Phe Arg Val 
    1580                 1585                 1590             


Gly Asn  Val Gln Glu Leu Ser  Glu Leu Ser Glu Gln  Val Leu Glu 
    1595                 1600                 1605             


Thr Leu  His Asp Ala Met His  Glu Thr Leu Cys Pro  Gly Val Thr 
    1610                 1615                 1620             


Asp Ala  Ala Lys Ala Cys Asn  Leu Asp Val Ile Leu  Gly Phe Asp 
    1625                 1630                 1635             


Gly Ser  Arg Asp Gln Asn Val  Phe Val Ala Gln Lys  Gly Phe Glu 
    1640                 1645                 1650             


Ser Lys  Val Asp Ala Ile Leu  Asn Arg Ile Ser Gln  Met His Arg 
    1655                 1660                 1665             


Val Ser  Cys Ser Gly Gly Arg  Ser Pro Thr Val Arg  Val Ser Val 
    1670                 1675                 1680             


Val Ala  Asn Thr Pro Ser Gly  Pro Val Glu Ala Phe  Asp Phe Asp 
    1685                 1690                 1695             


Glu Tyr  Gln Pro Glu Met Leu  Glu Lys Phe Arg Asn  Met Arg Ser 
    1700                 1705                 1710             


Gln His  Pro Tyr Val Leu Thr  Glu Asp Thr Leu Lys  Val Tyr Leu 
    1715                 1720                 1725             


Asn Lys  Phe Arg Gln Ser Ser  Pro Asp Ser Val Lys  Val Val Ile 
    1730                 1735                 1740             


His Phe  Thr Asp Gly Ala Asp  Gly Asp Leu Ala Asp  Leu His Arg 
    1745                 1750                 1755             


Ala Ser  Glu Asn Leu Arg Gln  Glu Gly Val Arg Ala  Leu Ile Leu 
    1760                 1765                 1770             


Val Gly  Leu Glu Arg Val Val  Asn Leu Glu Arg Leu  Met His Leu 
    1775                 1780                 1785             


Glu Phe  Gly Arg Gly Phe Met  Tyr Asp Arg Pro Leu  Arg Leu Asn 
    1790                 1795                 1800             


Leu Leu  Asp Leu Asp Tyr Glu  Leu Ala Glu Gln Leu  Asp Asn Ile 
    1805                 1810                 1815             


Ala Glu  Lys Ala Cys Cys Gly  Val Pro Cys Lys Cys  Ser Gly Gln 
    1820                 1825                 1830             


Arg Gly  Asp Arg Gly Pro Ile  Gly Ser Ile Gly Pro  Lys Gly Ile 
    1835                 1840                 1845             


Pro Gly  Glu Asp Gly Tyr Arg  Gly Tyr Pro Gly Asp  Glu Gly Gly 
    1850                 1855                 1860             


Pro Gly  Glu Arg Gly Pro Pro  Gly Val Asn Gly Thr  Gln Gly Phe 
    1865                 1870                 1875             


Gln Gly  Cys Pro Gly Gln Arg  Gly Val Lys Gly Ser  Arg Gly Phe 
    1880                 1885                 1890             


Pro Gly  Glu Lys Gly Glu Val  Gly Glu Ile Gly Leu  Asp Gly Leu 
    1895                 1900                 1905             


Asp Gly  Glu Asp Gly Asp Lys  Gly Leu Pro Gly Ser  Ser Gly Glu 
    1910                 1915                 1920             


Lys Gly  Asn Pro Gly Arg Arg  Gly Asp Lys Gly Pro  Arg Gly Glu 
    1925                 1930                 1935             


Lys Gly  Glu Arg Gly Asp Val  Gly Ile Arg Gly Asp  Pro Gly Asn 
    1940                 1945                 1950             


Pro Gly  Gln Asp Ser Gln Glu  Arg Gly Pro Lys Gly  Glu Thr Gly 
    1955                 1960                 1965             


Asp Leu  Gly Pro Met Gly Val  Pro Gly Arg Asp Gly  Val Pro Gly 
    1970                 1975                 1980             


Gly Pro  Gly Glu Thr Gly Lys  Asn Gly Gly Phe Gly  Arg Arg Gly 
    1985                 1990                 1995             


Pro Pro  Gly Ala Lys Gly Asn  Lys Gly Gly Pro Gly  Gln Pro Gly 
    2000                 2005                 2010             


Phe Glu  Gly Glu Gln Gly Thr  Arg Gly Ala Gln Gly  Pro Ala Gly 
    2015                 2020                 2025             


Pro Ala  Gly Pro Pro Gly Leu  Ile Gly Glu Gln Gly  Ile Ser Gly 
    2030                 2035                 2040             


Pro Arg  Gly Ser Gly Gly Ala  Ala Gly Ala Pro Gly  Glu Arg Gly 
    2045                 2050                 2055             


Arg Thr  Gly Pro Leu Gly Arg  Lys Gly Glu Pro Gly  Glu Pro Gly 
    2060                 2065                 2070             


Pro Lys  Gly Gly Ile Gly Asn  Arg Gly Pro Arg Gly  Glu Thr Gly 
    2075                 2080                 2085             


Asp Asp  Gly Arg Asp Gly Val  Gly Ser Glu Gly Arg  Arg Gly Lys 
    2090                 2095                 2100             


Lys Gly  Glu Arg Gly Phe Pro  Gly Tyr Pro Gly Pro  Lys Gly Asn 
    2105                 2110                 2115             


Pro Gly  Glu Pro Gly Leu Asn  Gly Thr Thr Gly Pro  Lys Gly Ile 
    2120                 2125                 2130             


Arg Gly  Arg Arg Gly Asn Ser  Gly Pro Pro Gly Ile  Val Gly Gln 
    2135                 2140                 2145             


Lys Gly  Asp Pro Gly Tyr Pro  Gly Pro Ala Gly Pro  Lys Gly Asn 
    2150                 2155                 2160             


Arg Gly  Asp Ser Ile Asp Gln  Cys Ala Leu Ile Gln  Ser Ile Lys 
    2165                 2170                 2175             


Asp Lys  Cys Pro Cys Cys Tyr  Gly Pro Leu Glu Cys  Pro Val Phe 
    2180                 2185                 2190             


Pro Thr  Glu Leu Ala Phe Ala  Leu Asp Thr Ser Glu  Gly Val Asn 
    2195                 2200                 2205             


Gln Asp  Thr Phe Gly Arg Met  Arg Asp Val Val Leu  Ser Ile Val 
    2210                 2215                 2220             


Asn Asp  Leu Thr Ile Ala Glu  Ser Asn Cys Pro Arg  Gly Ala Arg 
    2225                 2230                 2235             


Val Ala  Val Val Thr Tyr Asn  Asn Glu Val Thr Thr  Glu Ile Arg 
    2240                 2245                 2250             


Phe Ala  Asp Ser Lys Arg Lys  Ser Val Leu Leu Asp  Lys Ile Lys 
    2255                 2260                 2265             


Asn Leu  Gln Val Ala Leu Thr  Ser Lys Gln Gln Ser  Leu Glu Thr 
    2270                 2275                 2280             


Ala Met  Ser Phe Val Ala Arg  Asn Thr Phe Lys Arg  Val Arg Asn 
    2285                 2290                 2295             


Gly Phe  Leu Met Arg Lys Val  Ala Val Phe Phe Ser  Asn Thr Pro 
    2300                 2305                 2310             


Thr Arg  Ala Ser Pro Gln Leu  Arg Glu Ala Val Leu  Lys Leu Ser 
    2315                 2320                 2325             


Asp Ala  Gly Ile Thr Pro Leu  Phe Leu Thr Arg Gln  Glu Asp Arg 
    2330                 2335                 2340             


Gln Leu  Ile Asn Ala Leu Gln  Ile Asn Asn Thr Ala  Val Gly His 
    2345                 2350                 2355             


Ala Leu  Val Leu Pro Ala Gly  Arg Asp Leu Thr Asp  Phe Leu Glu 
    2360                 2365                 2370             


Asn Val  Leu Thr Cys His Val  Cys Leu Asp Ile Cys  Asn Ile Asp 
    2375                 2380                 2385             


Pro Ser  Cys Gly Phe Gly Ser  Trp Arg Pro Ser Phe  Arg Asp Arg 
    2390                 2395                 2400             


Arg Ala  Ala Gly Ser Asp Val  Asp Ile Asp Met Ala  Phe Ile Leu 
    2405                 2410                 2415             


Asp Ser  Ala Glu Thr Thr Thr  Leu Phe Gln Phe Asn  Glu Met Lys 
    2420                 2425                 2430             


Lys Tyr  Ile Ala Tyr Leu Val  Arg Gln Leu Asp Met  Ser Pro Asp 
    2435                 2440                 2445             


Pro Lys  Ala Ser Gln His Phe  Ala Arg Val Ala Val  Val Gln His 
    2450                 2455                 2460             


Ala Pro  Ser Glu Ser Val Asp  Asn Ala Ser Met Pro  Pro Val Lys 
    2465                 2470                 2475             


Val Glu  Phe Ser Leu Thr Asp  Tyr Gly Ser Lys Glu  Lys Leu Val 
    2480                 2485                 2490             


Asp Phe  Leu Ser Arg Gly Met  Thr Gln Leu Gln Gly  Thr Arg Ala 
    2495                 2500                 2505             


Leu Gly  Ser Ala Ile Glu Tyr  Thr Ile Glu Asn Val  Phe Glu Ser 
    2510                 2515                 2520             


Ala Pro  Asn Pro Arg Asp Leu  Lys Ile Val Val Leu  Met Leu Thr 
    2525                 2530                 2535             


Gly Glu  Val Pro Glu Gln Gln  Leu Glu Glu Ala Gln  Arg Val Ile 
    2540                 2545                 2550             


Leu Gln  Ala Lys Cys Lys Gly  Tyr Phe Phe Val Val  Leu Gly Ile 
    2555                 2560                 2565             


Gly Arg  Lys Val Asn Ile Lys  Glu Val Tyr Thr Phe  Ala Ser Glu 
    2570                 2575                 2580             


Pro Asn  Asp Val Phe Phe Lys  Leu Val Asp Lys Ser  Thr Glu Leu 
    2585                 2590                 2595             


Asn Glu  Glu Pro Leu Met Arg  Phe Gly Arg Leu Leu  Pro Ser Phe 
    2600                 2605                 2610             


Val Ser  Ser Glu Asn Ala Phe  Tyr Leu Ser Pro Asp  Ile Arg Lys 
    2615                 2620                 2625             


Gln Cys  Asp Trp Phe Gln Gly  Asp Gln Pro Thr Lys  Asn Leu Val 
    2630                 2635                 2640             


Lys Phe  Gly His Lys Gln Val  Asn Val Pro Asn Asn  Val Thr Ser 
    2645                 2650                 2655             


Ser Pro  Thr Ser Asn Pro Val  Thr Thr Thr Lys Pro  Val Thr Thr 
    2660                 2665                 2670             


Thr Lys  Pro Val Thr Thr Thr  Thr Lys Pro Val Thr  Thr Thr Thr 
    2675                 2680                 2685             


Lys Pro  Val Thr Ile Ile Asn  Gln Pro Ser Val Lys  Pro Ala Ala 
    2690                 2695                 2700             


Ala Lys  Pro Ala Pro Ala Lys  Pro Val Ala Ala Lys  Pro Val Ala 
    2705                 2710                 2715             


Thr Lys  Met Ala Thr Val Arg  Pro Pro Val Ala Val  Lys Pro Ala 
    2720                 2725                 2730             


Thr Ala  Ala Lys Pro Val Ala  Ala Lys Pro Ala Ala  Val Arg Pro 
    2735                 2740                 2745             


Pro Ala  Ala Ala Ala Ala Lys  Pro Val Ala Thr Lys  Pro Glu Val 
    2750                 2755                 2760             


Pro Arg  Pro Gln Ala Ala Lys  Pro Ala Ala Thr Lys  Pro Ala Thr 
    2765                 2770                 2775             


Thr Lys  Pro Met Val Lys Met  Ser Arg Glu Val Gln  Val Phe Glu 
    2780                 2785                 2790             


Ile Thr  Glu Asn Ser Ala Lys  Leu His Trp Glu Arg  Ala Glu Pro 
    2795                 2800                 2805             


Pro Gly  Pro Tyr Phe Tyr Asp  Leu Thr Val Thr Ser  Ala His Asp 
    2810                 2815                 2820             


Gln Ser  Leu Val Leu Lys Gln  Asn Leu Thr Val Thr  Asp Arg Val 
    2825                 2830                 2835             


Ile Gly  Gly Leu Leu Ala Gly  Gln Thr Tyr His Val  Ala Val Val 
    2840                 2845                 2850             


Cys Tyr  Leu Arg Ser Gln Val  Arg Ala Thr Tyr His  Gly Ser Phe 
    2855                 2860                 2865             


Ser Thr  Lys Lys Ser Gln Pro  Pro Pro Pro Gln Pro  Ala Arg Ser 
    2870                 2875                 2880             


Ala Ser  Ser Ser Thr Ile Asn  Leu Met Val Ser Thr  Glu Pro Leu 
    2885                 2890                 2895             


Ala Leu  Thr Glu Thr Asp Ile  Cys Lys Leu Pro Lys  Asp Glu Gly 
    2900                 2905                 2910             


Thr Cys  Arg Asp Phe Ile Leu  Lys Trp Tyr Tyr Asp  Pro Asn Thr 
    2915                 2920                 2925             


Lys Ser  Cys Ala Arg Phe Trp  Tyr Gly Gly Cys Gly  Gly Asn Glu 
    2930                 2935                 2940             


Asn Lys  Phe Gly Ser Gln Lys  Glu Cys Glu Lys Val  Cys Ala Pro 
    2945                 2950                 2955             


Val Leu  Ala Lys Pro Gly Val  Ile Ser Val Met Gly  Thr 
    2960                 2965                 2970     


<210>  115
<211>  2971
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Collagen type VI, alpha 3 Variant 3

<400>  115

Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe 
1               5                   10                  15      


Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Ala Gln 
            20                  25                  30          


Asp Ser Ala Asp Ile Ile Phe Leu Ile Asp Gly Ser Asn Asn Thr Gly 
        35                  40                  45              


Ser Val Asn Phe Ala Val Ile Leu Asp Phe Leu Val Asn Leu Leu Glu 
    50                  55                  60                  


Lys Leu Pro Ile Gly Thr Gln Gln Ile Arg Val Gly Val Val Gln Phe 
65                  70                  75                  80  


Ser Asp Glu Pro Arg Thr Met Phe Ser Leu Asp Thr Tyr Ser Thr Lys 
                85                  90                  95      


Ala Gln Val Leu Gly Ala Val Lys Ala Leu Gly Phe Ala Gly Gly Glu 
            100                 105                 110         


Leu Ala Asn Ile Gly Leu Ala Leu Asp Phe Val Val Glu Asn His Phe 
        115                 120                 125             


Thr Arg Ala Gly Gly Ser Arg Val Glu Glu Gly Val Pro Gln Val Leu 
    130                 135                 140                 


Val Leu Ile Ser Ala Gly Pro Ser Ser Asp Glu Ile Arg Tyr Gly Val 
145                 150                 155                 160 


Val Ala Leu Lys Gln Ala Ser Val Phe Ser Phe Gly Leu Gly Ala Gln 
                165                 170                 175     


Ala Ala Ser Arg Ala Glu Leu Gln His Ile Ala Thr Asp Asp Asn Leu 
            180                 185                 190         


Val Phe Thr Val Pro Glu Phe Arg Ser Phe Gly Asp Leu Gln Glu Lys 
        195                 200                 205             


Leu Leu Pro Tyr Ile Val Gly Val Ala Gln Arg His Ile Val Leu Lys 
    210                 215                 220                 


Pro Pro Thr Ile Val Thr Gln Val Ile Glu Val Asn Lys Arg Asp Ile 
225                 230                 235                 240 


Val Phe Leu Val Asp Gly Ser Ser Ala Leu Gly Leu Ala Asn Phe Asn 
                245                 250                 255     


Ala Ile Arg Asp Phe Ile Ala Lys Val Ile Gln Arg Leu Glu Ile Gly 
            260                 265                 270         


Gln Asp Leu Ile Gln Val Ala Val Ala Gln Tyr Ala Asp Thr Val Arg 
        275                 280                 285             


Pro Glu Phe Tyr Phe Asn Thr His Pro Thr Lys Arg Glu Val Ile Thr 
    290                 295                 300                 


Ala Val Arg Lys Met Lys Pro Leu Asp Gly Ser Ala Leu Tyr Thr Gly 
305                 310                 315                 320 


Ser Ala Leu Asp Phe Val Arg Asn Asn Leu Phe Thr Ser Ser Ala Gly 
                325                 330                 335     


Tyr Arg Ala Ala Glu Gly Ile Pro Lys Leu Leu Val Leu Ile Thr Gly 
            340                 345                 350         


Gly Lys Ser Leu Asp Glu Ile Ser Gln Pro Ala Gln Glu Leu Lys Arg 
        355                 360                 365             


Ser Ser Ile Met Ala Phe Ala Ile Gly Asn Lys Gly Ala Asp Gln Ala 
    370                 375                 380                 


Glu Leu Glu Glu Ile Ala Phe Asp Ser Ser Leu Val Phe Ile Pro Ala 
385                 390                 395                 400 


Glu Phe Arg Ala Ala Pro Leu Gln Gly Met Leu Pro Gly Leu Leu Ala 
                405                 410                 415     


Pro Leu Arg Thr Leu Ser Gly Thr Pro Glu Val His Ser Asn Lys Arg 
            420                 425                 430         


Asp Ile Ile Phe Leu Leu Asp Gly Ser Ala Asn Val Gly Lys Thr Asn 
        435                 440                 445             


Phe Pro Tyr Val Arg Asp Phe Val Met Asn Leu Val Asn Ser Leu Asp 
    450                 455                 460                 


Ile Gly Asn Asp Asn Ile Arg Val Gly Leu Val Gln Phe Ser Asp Thr 
465                 470                 475                 480 


Pro Val Thr Glu Phe Ser Leu Asn Thr Tyr Gln Thr Lys Ser Asp Ile 
                485                 490                 495     


Leu Gly His Leu Arg Gln Leu Gln Leu Gln Gly Gly Ser Gly Leu Asn 
            500                 505                 510         


Thr Gly Ser Ala Leu Ser Tyr Val Tyr Ala Asn His Phe Thr Glu Ala 
        515                 520                 525             


Gly Gly Ser Arg Ile Arg Glu His Val Pro Gln Leu Leu Leu Leu Leu 
    530                 535                 540                 


Thr Ala Gly Gln Ser Glu Asp Ser Tyr Leu Gln Ala Ala Asn Ala Leu 
545                 550                 555                 560 


Thr Arg Ala Gly Ile Leu Thr Phe Cys Val Gly Ala Ser Gln Ala Asn 
                565                 570                 575     


Lys Ala Glu Leu Glu Gln Ile Ala Phe Asn Pro Ser Leu Val Tyr Leu 
            580                 585                 590         


Met Asp Asp Phe Ser Ser Leu Pro Ala Leu Pro Gln Gln Leu Ile Gln 
        595                 600                 605             


Pro Leu Thr Thr Tyr Val Ser Gly Gly Val Glu Glu Val Pro Leu Ala 
    610                 615                 620                 


Gln Pro Glu Ser Lys Arg Asp Ile Leu Phe Leu Phe Asp Gly Ser Ala 
625                 630                 635                 640 


Asn Leu Val Gly Gln Phe Pro Val Val Arg Asp Phe Leu Tyr Lys Ile 
                645                 650                 655     


Ile Asp Glu Leu Asn Val Lys Pro Glu Gly Thr Arg Ile Ala Val Ala 
            660                 665                 670         


Gln Tyr Ser Asp Asp Val Lys Val Glu Ser Arg Phe Asp Glu His Gln 
        675                 680                 685             


Ser Lys Pro Glu Ile Leu Asn Leu Val Lys Arg Met Lys Ile Lys Thr 
    690                 695                 700                 


Gly Lys Ala Leu Asn Leu Gly Tyr Ala Leu Asp Tyr Ala Gln Arg Tyr 
705                 710                 715                 720 


Ile Phe Val Lys Ser Ala Gly Ser Arg Ile Glu Asp Gly Val Leu Gln 
                725                 730                 735     


Phe Leu Val Leu Leu Val Ala Gly Arg Ser Ser Asp Arg Val Asp Gly 
            740                 745                 750         


Pro Ala Ser Asn Leu Lys Gln Ser Gly Val Val Pro Phe Ile Phe Gln 
        755                 760                 765             


Ala Lys Asn Ala Asp Pro Ala Glu Leu Glu Gln Ile Val Leu Ser Pro 
    770                 775                 780                 


Ala Phe Ile Leu Ala Ala Glu Ser Leu Pro Lys Ile Gly Asp Leu His 
785                 790                 795                 800 


Pro Gln Ile Val Asn Leu Leu Lys Ser Val His Asn Gly Ala Pro Ala 
                805                 810                 815     


Pro Val Ser Gly Glu Lys Asp Val Val Phe Leu Leu Asp Gly Ser Glu 
            820                 825                 830         


Gly Val Arg Ser Gly Phe Pro Leu Leu Lys Glu Phe Val Gln Arg Val 
        835                 840                 845             


Val Glu Ser Leu Asp Val Gly Gln Asp Arg Val Arg Val Ala Val Val 
    850                 855                 860                 


Gln Tyr Ser Asp Arg Thr Arg Pro Glu Phe Tyr Leu Asn Ser Tyr Met 
865                 870                 875                 880 


Asn Lys Gln Asp Val Val Asn Ala Val Arg Gln Leu Thr Leu Leu Gly 
                885                 890                 895     


Gly Pro Thr Pro Asn Thr Gly Ala Ala Leu Glu Phe Val Leu Arg Asn 
            900                 905                 910         


Ile Leu Val Ser Ser Ala Gly Ser Arg Ile Thr Glu Gly Val Pro Gln 
        915                 920                 925             


Leu Leu Ile Val Leu Thr Ala Asp Arg Ser Gly Asp Asp Val Arg Asn 
    930                 935                 940                 


Pro Ser Val Val Val Lys Arg Gly Gly Ala Val Pro Ile Gly Ile Gly 
945                 950                 955                 960 


Ile Gly Asn Ala Asp Ile Thr Glu Met Gln Thr Ile Ser Phe Ile Pro 
                965                 970                 975     


Asp Phe Ala Val Ala Ile Pro Thr Phe Arg Gln Leu Gly Thr Val Gln 
            980                 985                 990         


Gln Val Ile Ser Glu Arg Val Thr  Gln Leu Thr Arg Glu  Glu Leu Ser 
        995                 1000                 1005             


Arg Leu  Gln Pro Val Leu Gln  Pro Leu Pro Ser Pro  Gly Val Gly 
    1010                 1015                 1020             


Gly Lys  Arg Asp Val Val Phe  Leu Ile Asp Gly Ser  Gln Ser Ala 
    1025                 1030                 1035             


Gly Pro  Glu Phe Gln Tyr Val  Arg Thr Leu Ile Glu  Arg Leu Val 
    1040                 1045                 1050             


Asp Tyr  Leu Asp Val Gly Phe  Asp Thr Thr Arg Val  Ala Val Ile 
    1055                 1060                 1065             


Gln Phe  Ser Asp Asp Pro Lys  Val Glu Phe Leu Leu  Asn Ala His 
    1070                 1075                 1080             


Ser Ser  Lys Asp Glu Val Gln  Asn Ala Val Gln Arg  Leu Arg Pro 
    1085                 1090                 1095             


Lys Gly  Gly Arg Gln Ile Asn  Val Gly Asn Ala Leu  Glu Tyr Val 
    1100                 1105                 1110             


Ser Arg  Asn Ile Phe Lys Arg  Pro Leu Gly Ser Arg  Ile Glu Glu 
    1115                 1120                 1125             


Gly Val  Pro Gln Phe Leu Val  Leu Ile Ser Ser Gly  Lys Ser Asp 
    1130                 1135                 1140             


Asp Glu  Val Asp Asp Pro Ala  Val Glu Leu Lys Gln  Phe Gly Val 
    1145                 1150                 1155             


Ala Pro  Phe Thr Ile Ala Arg  Asn Ala Asp Gln Glu  Glu Leu Val 
    1160                 1165                 1170             


Lys Ile  Ser Leu Ser Pro Glu  Tyr Val Phe Ser Val  Ser Thr Phe 
    1175                 1180                 1185             


Arg Glu  Leu Pro Ser Leu Glu  Gln Lys Leu Leu Thr  Pro Ile Thr 
    1190                 1195                 1200             


Thr Leu  Thr Ser Glu Gln Ile  Gln Lys Leu Leu Ala  Ser Thr Arg 
    1205                 1210                 1215             


Tyr Pro  Pro Pro Ala Val Glu  Ser Asp Ala Ala Asp  Ile Val Phe 
    1220                 1225                 1230             


Leu Ile  Asp Ser Ser Glu Gly  Val Arg Pro Asp Gly  Phe Ala His 
    1235                 1240                 1245             


Ile Arg  Asp Phe Val Ser Arg  Ile Val Arg Arg Leu  Asn Ile Gly 
    1250                 1255                 1260             


Pro Ser  Lys Val Arg Val Gly  Val Val Gln Phe Ser  Asn Asp Val 
    1265                 1270                 1275             


Phe Pro  Glu Phe Tyr Leu Lys  Thr Tyr Arg Ser Gln  Ala Pro Val 
    1280                 1285                 1290             


Leu Asp  Ala Ile Arg Arg Leu  Arg Leu Arg Gly Gly  Ser Pro Leu 
    1295                 1300                 1305             


Asn Thr  Gly Lys Ala Leu Glu  Phe Val Ala Arg Asn  Leu Phe Val 
    1310                 1315                 1320             


Lys Ser  Ala Gly Ser Arg Ile  Glu Asp Gly Val Pro  Gln His Leu 
    1325                 1330                 1335             


Val Leu  Val Leu Gly Gly Lys  Ser Gln Asp Asp Val  Ser Arg Phe 
    1340                 1345                 1350             


Ala Gln  Val Ile Arg Ser Ser  Gly Ile Val Ser Leu  Gly Val Gly 
    1355                 1360                 1365             


Asp Arg  Asn Ile Asp Arg Thr  Glu Leu Gln Thr Ile  Thr Asn Asp 
    1370                 1375                 1380             


Pro Arg  Leu Val Phe Thr Val  Arg Glu Phe Arg Glu  Leu Pro Asn 
    1385                 1390                 1395             


Ile Glu  Glu Arg Ile Met Asn  Ser Phe Gly Pro Ser  Ala Ala Thr 
    1400                 1405                 1410             


Pro Ala  Pro Pro Gly Val Asp  Thr Pro Pro Pro Ser  Arg Pro Glu 
    1415                 1420                 1425             


Lys Lys  Lys Ala Asp Ile Val  Phe Leu Leu Asp Gly  Ser Ile Asn 
    1430                 1435                 1440             


Phe Arg  Arg Asp Ser Phe Gln  Glu Val Leu Arg Phe  Val Ser Glu 
    1445                 1450                 1455             


Ile Val  Asp Thr Val Tyr Glu  Asp Gly Asp Ser Ile  Gln Val Gly 
    1460                 1465                 1470             


Leu Val  Gln Tyr Asn Ser Asp  Pro Thr Asp Glu Phe  Phe Leu Lys 
    1475                 1480                 1485             


Asp Phe  Ser Thr Lys Arg Gln  Ile Ile Asp Ala Ile  Asn Lys Val 
    1490                 1495                 1500             


Val Tyr  Lys Gly Gly Arg His  Ala Asn Thr Lys Val  Gly Leu Glu 
    1505                 1510                 1515             


His Leu  Arg Val Asn His Phe  Val Pro Glu Ala Gly  Ser Arg Leu 
    1520                 1525                 1530             


Asp Gln  Arg Val Pro Gln Ile  Ala Phe Val Ile Thr  Gly Gly Lys 
    1535                 1540                 1545             


Ser Val  Glu Asp Ala Gln Asp  Val Ser Leu Ala Leu  Thr Gln Arg 
    1550                 1555                 1560             


Gly Val  Lys Val Phe Ala Val  Gly Val Arg Asn Ile  Asp Ser Glu 
    1565                 1570                 1575             


Glu Val  Gly Lys Ile Ala Ser  Asn Ser Ala Thr Ala  Phe Arg Val 
    1580                 1585                 1590             


Gly Asn  Val Gln Glu Leu Ser  Glu Leu Ser Glu Gln  Val Leu Glu 
    1595                 1600                 1605             


Thr Leu  His Asp Ala Met His  Glu Thr Leu Cys Pro  Gly Val Thr 
    1610                 1615                 1620             


Asp Ala  Ala Lys Ala Cys Asn  Leu Asp Val Ile Leu  Gly Phe Asp 
    1625                 1630                 1635             


Gly Ser  Arg Asp Gln Asn Val  Phe Val Ala Gln Lys  Gly Phe Glu 
    1640                 1645                 1650             


Ser Lys  Val Asp Ala Ile Leu  Asn Arg Ile Ser Gln  Met His Arg 
    1655                 1660                 1665             


Val Ser  Cys Ser Gly Gly Arg  Ser Pro Thr Val Arg  Val Ser Val 
    1670                 1675                 1680             


Val Ala  Asn Thr Pro Ser Gly  Pro Val Glu Ala Phe  Asp Phe Asp 
    1685                 1690                 1695             


Glu Tyr  Gln Pro Glu Met Leu  Glu Lys Phe Arg Asn  Met Arg Ser 
    1700                 1705                 1710             


Gln His  Pro Tyr Val Leu Thr  Glu Asp Thr Leu Lys  Val Tyr Leu 
    1715                 1720                 1725             


Asn Lys  Phe Arg Gln Ser Ser  Pro Asp Ser Val Lys  Val Val Ile 
    1730                 1735                 1740             


His Phe  Thr Asp Gly Ala Asp  Gly Asp Leu Ala Asp  Leu His Arg 
    1745                 1750                 1755             


Ala Ser  Glu Asn Leu Arg Gln  Glu Gly Val Arg Ala  Leu Ile Leu 
    1760                 1765                 1770             


Val Gly  Leu Glu Arg Val Val  Asn Leu Glu Arg Leu  Met His Leu 
    1775                 1780                 1785             


Glu Phe  Gly Arg Gly Phe Met  Tyr Asp Arg Pro Leu  Arg Leu Asn 
    1790                 1795                 1800             


Leu Leu  Asp Leu Asp Tyr Glu  Leu Ala Glu Gln Leu  Asp Asn Ile 
    1805                 1810                 1815             


Ala Glu  Lys Ala Cys Cys Gly  Val Pro Cys Lys Cys  Ser Gly Gln 
    1820                 1825                 1830             


Arg Gly  Asp Arg Gly Pro Ile  Gly Ser Ile Gly Pro  Lys Gly Ile 
    1835                 1840                 1845             


Pro Gly  Glu Asp Gly Tyr Arg  Gly Tyr Pro Gly Asp  Glu Gly Gly 
    1850                 1855                 1860             


Pro Gly  Glu Arg Gly Pro Pro  Gly Val Asn Gly Thr  Gln Gly Phe 
    1865                 1870                 1875             


Gln Gly  Cys Pro Gly Gln Arg  Gly Val Lys Gly Ser  Arg Gly Phe 
    1880                 1885                 1890             


Pro Gly  Glu Lys Gly Glu Val  Gly Glu Ile Gly Leu  Asp Gly Leu 
    1895                 1900                 1905             


Asp Gly  Glu Asp Gly Asp Lys  Gly Leu Pro Gly Ser  Ser Gly Glu 
    1910                 1915                 1920             


Lys Gly  Asn Pro Gly Arg Arg  Gly Asp Lys Gly Pro  Arg Gly Glu 
    1925                 1930                 1935             


Lys Gly  Glu Arg Gly Asp Val  Gly Ile Arg Gly Asp  Pro Gly Asn 
    1940                 1945                 1950             


Pro Gly  Gln Asp Ser Gln Glu  Arg Gly Pro Lys Gly  Glu Thr Gly 
    1955                 1960                 1965             


Asp Leu  Gly Pro Met Gly Val  Pro Gly Arg Asp Gly  Val Pro Gly 
    1970                 1975                 1980             


Gly Pro  Gly Glu Thr Gly Lys  Asn Gly Gly Phe Gly  Arg Arg Gly 
    1985                 1990                 1995             


Pro Pro  Gly Ala Lys Gly Asn  Lys Gly Gly Pro Gly  Gln Pro Gly 
    2000                 2005                 2010             


Phe Glu  Gly Glu Gln Gly Thr  Arg Gly Ala Gln Gly  Pro Ala Gly 
    2015                 2020                 2025             


Pro Ala  Gly Pro Pro Gly Leu  Ile Gly Glu Gln Gly  Ile Ser Gly 
    2030                 2035                 2040             


Pro Arg  Gly Ser Gly Gly Ala  Ala Gly Ala Pro Gly  Glu Arg Gly 
    2045                 2050                 2055             


Arg Thr  Gly Pro Leu Gly Arg  Lys Gly Glu Pro Gly  Glu Pro Gly 
    2060                 2065                 2070             


Pro Lys  Gly Gly Ile Gly Asn  Arg Gly Pro Arg Gly  Glu Thr Gly 
    2075                 2080                 2085             


Asp Asp  Gly Arg Asp Gly Val  Gly Ser Glu Gly Arg  Arg Gly Lys 
    2090                 2095                 2100             


Lys Gly  Glu Arg Gly Phe Pro  Gly Tyr Pro Gly Pro  Lys Gly Asn 
    2105                 2110                 2115             


Pro Gly  Glu Pro Gly Leu Asn  Gly Thr Thr Gly Pro  Lys Gly Ile 
    2120                 2125                 2130             


Arg Gly  Arg Arg Gly Asn Ser  Gly Pro Pro Gly Ile  Val Gly Gln 
    2135                 2140                 2145             


Lys Gly  Asp Pro Gly Tyr Pro  Gly Pro Ala Gly Pro  Lys Gly Asn 
    2150                 2155                 2160             


Arg Gly  Asp Ser Ile Asp Gln  Cys Ala Leu Ile Gln  Ser Ile Lys 
    2165                 2170                 2175             


Asp Lys  Cys Pro Cys Cys Tyr  Gly Pro Leu Glu Cys  Pro Val Phe 
    2180                 2185                 2190             


Pro Thr  Glu Leu Ala Phe Ala  Leu Asp Thr Ser Glu  Gly Val Asn 
    2195                 2200                 2205             


Gln Asp  Thr Phe Gly Arg Met  Arg Asp Val Val Leu  Ser Ile Val 
    2210                 2215                 2220             


Asn Asp  Leu Thr Ile Ala Glu  Ser Asn Cys Pro Arg  Gly Ala Arg 
    2225                 2230                 2235             


Val Ala  Val Val Thr Tyr Asn  Asn Glu Val Thr Thr  Glu Ile Arg 
    2240                 2245                 2250             


Phe Ala  Asp Ser Lys Arg Lys  Ser Val Leu Leu Asp  Lys Ile Lys 
    2255                 2260                 2265             


Asn Leu  Gln Val Ala Leu Thr  Ser Lys Gln Gln Ser  Leu Glu Thr 
    2270                 2275                 2280             


Ala Met  Ser Phe Val Ala Arg  Asn Thr Phe Lys Arg  Val Arg Asn 
    2285                 2290                 2295             


Gly Phe  Leu Met Arg Lys Val  Ala Val Phe Phe Ser  Asn Thr Pro 
    2300                 2305                 2310             


Thr Arg  Ala Ser Pro Gln Leu  Arg Glu Ala Val Leu  Lys Leu Ser 
    2315                 2320                 2325             


Asp Ala  Gly Ile Thr Pro Leu  Phe Leu Thr Arg Gln  Glu Asp Arg 
    2330                 2335                 2340             


Gln Leu  Ile Asn Ala Leu Gln  Ile Asn Asn Thr Ala  Val Gly His 
    2345                 2350                 2355             


Ala Leu  Val Leu Pro Ala Gly  Arg Asp Leu Thr Asp  Phe Leu Glu 
    2360                 2365                 2370             


Asn Val  Leu Thr Cys His Val  Cys Leu Asp Ile Cys  Asn Ile Asp 
    2375                 2380                 2385             


Pro Ser  Cys Gly Phe Gly Ser  Trp Arg Pro Ser Phe  Arg Asp Arg 
    2390                 2395                 2400             


Arg Ala  Ala Gly Ser Asp Val  Asp Ile Asp Met Ala  Phe Ile Leu 
    2405                 2410                 2415             


Asp Ser  Ala Glu Thr Thr Thr  Leu Phe Gln Phe Asn  Glu Met Lys 
    2420                 2425                 2430             


Lys Tyr  Ile Ala Tyr Leu Val  Arg Gln Leu Asp Met  Ser Pro Asp 
    2435                 2440                 2445             


Pro Lys  Ala Ser Gln His Phe  Ala Arg Val Ala Val  Val Gln His 
    2450                 2455                 2460             


Ala Pro  Ser Glu Ser Val Asp  Asn Ala Ser Met Pro  Pro Val Lys 
    2465                 2470                 2475             


Val Glu  Phe Ser Leu Thr Asp  Tyr Gly Ser Lys Glu  Lys Leu Val 
    2480                 2485                 2490             


Asp Phe  Leu Ser Arg Gly Met  Thr Gln Leu Gln Gly  Thr Arg Ala 
    2495                 2500                 2505             


Leu Gly  Ser Ala Ile Glu Tyr  Thr Ile Glu Asn Val  Phe Glu Ser 
    2510                 2515                 2520             


Ala Pro  Asn Pro Arg Asp Leu  Lys Ile Val Val Leu  Met Leu Thr 
    2525                 2530                 2535             


Gly Glu  Val Pro Glu Gln Gln  Leu Glu Glu Ala Gln  Arg Val Ile 
    2540                 2545                 2550             


Leu Gln  Ala Lys Cys Lys Gly  Tyr Phe Phe Val Val  Leu Gly Ile 
    2555                 2560                 2565             


Gly Arg  Lys Val Asn Ile Lys  Glu Val Tyr Thr Phe  Ala Ser Glu 
    2570                 2575                 2580             


Pro Asn  Asp Val Phe Phe Lys  Leu Val Asp Lys Ser  Thr Glu Leu 
    2585                 2590                 2595             


Asn Glu  Glu Pro Leu Met Arg  Phe Gly Arg Leu Leu  Pro Ser Phe 
    2600                 2605                 2610             


Val Ser  Ser Glu Asn Ala Phe  Tyr Leu Ser Pro Asp  Ile Arg Lys 
    2615                 2620                 2625             


Gln Cys  Asp Trp Phe Gln Gly  Asp Gln Pro Thr Lys  Asn Leu Val 
    2630                 2635                 2640             


Lys Phe  Gly His Lys Gln Val  Asn Val Pro Asn Asn  Val Thr Ser 
    2645                 2650                 2655             


Ser Pro  Thr Ser Asn Pro Val  Thr Thr Thr Lys Pro  Val Thr Thr 
    2660                 2665                 2670             


Thr Lys  Pro Val Thr Thr Thr  Thr Lys Pro Val Thr  Thr Thr Thr 
    2675                 2680                 2685             


Lys Pro  Val Thr Ile Ile Asn  Gln Pro Ser Val Lys  Pro Ala Ala 
    2690                 2695                 2700             


Ala Lys  Pro Ala Pro Ala Lys  Pro Val Ala Ala Lys  Pro Val Ala 
    2705                 2710                 2715             


Thr Lys  Met Ala Thr Val Arg  Pro Pro Val Ala Val  Lys Pro Ala 
    2720                 2725                 2730             


Thr Ala  Ala Lys Pro Val Ala  Ala Lys Pro Ala Ala  Val Arg Pro 
    2735                 2740                 2745             


Pro Ala  Ala Ala Ala Ala Lys  Pro Val Ala Thr Lys  Pro Glu Val 
    2750                 2755                 2760             


Pro Arg  Pro Gln Ala Ala Lys  Pro Ala Ala Thr Lys  Pro Ala Thr 
    2765                 2770                 2775             


Thr Lys  Pro Met Val Lys Met  Ser Arg Glu Val Gln  Val Phe Glu 
    2780                 2785                 2790             


Ile Thr  Glu Asn Ser Ala Lys  Leu His Trp Glu Arg  Ala Glu Pro 
    2795                 2800                 2805             


Pro Gly  Pro Tyr Phe Tyr Asp  Leu Thr Val Thr Ser  Ala His Asp 
    2810                 2815                 2820             


Gln Ser  Leu Val Leu Lys Gln  Asn Leu Thr Val Thr  Asp Arg Val 
    2825                 2830                 2835             


Ile Gly  Gly Leu Leu Ala Gly  Gln Thr Tyr His Val  Ala Val Val 
    2840                 2845                 2850             


Cys Tyr  Leu Arg Ser Gln Val  Arg Ala Thr Tyr His  Gly Ser Phe 
    2855                 2860                 2865             


Ser Thr  Lys Lys Ser Gln Pro  Pro Pro Pro Gln Pro  Ala Arg Ser 
    2870                 2875                 2880             


Ala Ser  Ser Ser Thr Ile Asn  Leu Met Val Ser Thr  Glu Pro Leu 
    2885                 2890                 2895             


Ala Leu  Thr Glu Thr Asp Ile  Cys Lys Leu Pro Lys  Asp Glu Gly 
    2900                 2905                 2910             


Thr Cys  Arg Asp Phe Ile Leu  Lys Trp Tyr Tyr Asp  Pro Asn Thr 
    2915                 2920                 2925             


Lys Ser  Cys Ala Arg Phe Trp  Tyr Gly Gly Cys Gly  Gly Asn Glu 
    2930                 2935                 2940             


Asn Lys  Phe Gly Ser Gln Lys  Glu Cys Glu Lys Val  Cys Ala Pro 
    2945                 2950                 2955             


Val Leu  Ala Lys Pro Gly Val  Ile Ser Val Met Gly  Thr 
    2960                 2965                 2970     


<210>  116
<211>  2570
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Collagen type VI, alpha 3 Variant 4

<400>  116

Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe 
1               5                   10                  15      


Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Val Ile 
            20                  25                  30          


Glu Val Asn Lys Arg Asp Ile Val Phe Leu Val Asp Gly Ser Ser Ala 
        35                  40                  45              


Leu Gly Leu Ala Asn Phe Asn Ala Ile Arg Asp Phe Ile Ala Lys Val 
    50                  55                  60                  


Ile Gln Arg Leu Glu Ile Gly Gln Asp Leu Ile Gln Val Ala Val Ala 
65                  70                  75                  80  


Gln Tyr Ala Asp Thr Val Arg Pro Glu Phe Tyr Phe Asn Thr His Pro 
                85                  90                  95      


Thr Lys Arg Glu Val Ile Thr Ala Val Arg Lys Met Lys Pro Leu Asp 
            100                 105                 110         


Gly Ser Ala Leu Tyr Thr Gly Ser Ala Leu Asp Phe Val Arg Asn Asn 
        115                 120                 125             


Leu Phe Thr Ser Ser Ala Gly Tyr Arg Ala Ala Glu Gly Ile Pro Lys 
    130                 135                 140                 


Leu Leu Val Leu Ile Thr Gly Gly Lys Ser Leu Asp Glu Ile Ser Gln 
145                 150                 155                 160 


Pro Ala Gln Glu Leu Lys Arg Ser Ser Ile Met Ala Phe Ala Ile Gly 
                165                 170                 175     


Asn Lys Gly Ala Asp Gln Ala Glu Leu Glu Glu Ile Ala Phe Asp Ser 
            180                 185                 190         


Ser Leu Val Phe Ile Pro Ala Glu Phe Arg Ala Ala Pro Leu Gln Gly 
        195                 200                 205             


Met Leu Pro Gly Leu Leu Ala Pro Leu Arg Thr Leu Ser Gly Thr Pro 
    210                 215                 220                 


Glu Glu Ser Lys Arg Asp Ile Leu Phe Leu Phe Asp Gly Ser Ala Asn 
225                 230                 235                 240 


Leu Val Gly Gln Phe Pro Val Val Arg Asp Phe Leu Tyr Lys Ile Ile 
                245                 250                 255     


Asp Glu Leu Asn Val Lys Pro Glu Gly Thr Arg Ile Ala Val Ala Gln 
            260                 265                 270         


Tyr Ser Asp Asp Val Lys Val Glu Ser Arg Phe Asp Glu His Gln Ser 
        275                 280                 285             


Lys Pro Glu Ile Leu Asn Leu Val Lys Arg Met Lys Ile Lys Thr Gly 
    290                 295                 300                 


Lys Ala Leu Asn Leu Gly Tyr Ala Leu Asp Tyr Ala Gln Arg Tyr Ile 
305                 310                 315                 320 


Phe Val Lys Ser Ala Gly Ser Arg Ile Glu Asp Gly Val Leu Gln Phe 
                325                 330                 335     


Leu Val Leu Leu Val Ala Gly Arg Ser Ser Asp Arg Val Asp Gly Pro 
            340                 345                 350         


Ala Ser Asn Leu Lys Gln Ser Gly Val Val Pro Phe Ile Phe Gln Ala 
        355                 360                 365             


Lys Asn Ala Asp Pro Ala Glu Leu Glu Gln Ile Val Leu Ser Pro Ala 
    370                 375                 380                 


Phe Ile Leu Ala Ala Glu Ser Leu Pro Lys Ile Gly Asp Leu His Pro 
385                 390                 395                 400 


Gln Ile Val Asn Leu Leu Lys Ser Val His Asn Gly Ala Pro Ala Pro 
                405                 410                 415     


Val Ser Gly Glu Lys Asp Val Val Phe Leu Leu Asp Gly Ser Glu Gly 
            420                 425                 430         


Val Arg Ser Gly Phe Pro Leu Leu Lys Glu Phe Val Gln Arg Val Val 
        435                 440                 445             


Glu Ser Leu Asp Val Gly Gln Asp Arg Val Arg Val Ala Val Val Gln 
    450                 455                 460                 


Tyr Ser Asp Arg Thr Arg Pro Glu Phe Tyr Leu Asn Ser Tyr Met Asn 
465                 470                 475                 480 


Lys Gln Asp Val Val Asn Ala Val Arg Gln Leu Thr Leu Leu Gly Gly 
                485                 490                 495     


Pro Thr Pro Asn Thr Gly Ala Ala Leu Glu Phe Val Leu Arg Asn Ile 
            500                 505                 510         


Leu Val Ser Ser Ala Gly Ser Arg Ile Thr Glu Gly Val Pro Gln Leu 
        515                 520                 525             


Leu Ile Val Leu Thr Ala Asp Arg Ser Gly Asp Asp Val Arg Asn Pro 
    530                 535                 540                 


Ser Val Val Val Lys Arg Gly Gly Ala Val Pro Ile Gly Ile Gly Ile 
545                 550                 555                 560 


Gly Asn Ala Asp Ile Thr Glu Met Gln Thr Ile Ser Phe Ile Pro Asp 
                565                 570                 575     


Phe Ala Val Ala Ile Pro Thr Phe Arg Gln Leu Gly Thr Val Gln Gln 
            580                 585                 590         


Val Ile Ser Glu Arg Val Thr Gln Leu Thr Arg Glu Glu Leu Ser Arg 
        595                 600                 605             


Leu Gln Pro Val Leu Gln Pro Leu Pro Ser Pro Gly Val Gly Gly Lys 
    610                 615                 620                 


Arg Asp Val Val Phe Leu Ile Asp Gly Ser Gln Ser Ala Gly Pro Glu 
625                 630                 635                 640 


Phe Gln Tyr Val Arg Thr Leu Ile Glu Arg Leu Val Asp Tyr Leu Asp 
                645                 650                 655     


Val Gly Phe Asp Thr Thr Arg Val Ala Val Ile Gln Phe Ser Asp Asp 
            660                 665                 670         


Pro Lys Val Glu Phe Leu Leu Asn Ala His Ser Ser Lys Asp Glu Val 
        675                 680                 685             


Gln Asn Ala Val Gln Arg Leu Arg Pro Lys Gly Gly Arg Gln Ile Asn 
    690                 695                 700                 


Val Gly Asn Ala Leu Glu Tyr Val Ser Arg Asn Ile Phe Lys Arg Pro 
705                 710                 715                 720 


Leu Gly Ser Arg Ile Glu Glu Gly Val Pro Gln Phe Leu Val Leu Ile 
                725                 730                 735     


Ser Ser Gly Lys Ser Asp Asp Glu Val Asp Asp Pro Ala Val Glu Leu 
            740                 745                 750         


Lys Gln Phe Gly Val Ala Pro Phe Thr Ile Ala Arg Asn Ala Asp Gln 
        755                 760                 765             


Glu Glu Leu Val Lys Ile Ser Leu Ser Pro Glu Tyr Val Phe Ser Val 
    770                 775                 780                 


Ser Thr Phe Arg Glu Leu Pro Ser Leu Glu Gln Lys Leu Leu Thr Pro 
785                 790                 795                 800 


Ile Thr Thr Leu Thr Ser Glu Gln Ile Gln Lys Leu Leu Ala Ser Thr 
                805                 810                 815     


Arg Tyr Pro Pro Pro Ala Val Glu Ser Asp Ala Ala Asp Ile Val Phe 
            820                 825                 830         


Leu Ile Asp Ser Ser Glu Gly Val Arg Pro Asp Gly Phe Ala His Ile 
        835                 840                 845             


Arg Asp Phe Val Ser Arg Ile Val Arg Arg Leu Asn Ile Gly Pro Ser 
    850                 855                 860                 


Lys Val Arg Val Gly Val Val Gln Phe Ser Asn Asp Val Phe Pro Glu 
865                 870                 875                 880 


Phe Tyr Leu Lys Thr Tyr Arg Ser Gln Ala Pro Val Leu Asp Ala Ile 
                885                 890                 895     


Arg Arg Leu Arg Leu Arg Gly Gly Ser Pro Leu Asn Thr Gly Lys Ala 
            900                 905                 910         


Leu Glu Phe Val Ala Arg Asn Leu Phe Val Lys Ser Ala Gly Ser Arg 
        915                 920                 925             


Ile Glu Asp Gly Val Pro Gln His Leu Val Leu Val Leu Gly Gly Lys 
    930                 935                 940                 


Ser Gln Asp Asp Val Ser Arg Phe Ala Gln Val Ile Arg Ser Ser Gly 
945                 950                 955                 960 


Ile Val Ser Leu Gly Val Gly Asp Arg Asn Ile Asp Arg Thr Glu Leu 
                965                 970                 975     


Gln Thr Ile Thr Asn Asp Pro Arg Leu Val Phe Thr Val Arg Glu Phe 
            980                 985                 990         


Arg Glu Leu Pro Asn Ile Glu Glu  Arg Ile Met Asn Ser  Phe Gly Pro 
        995                 1000                 1005             


Ser Ala  Ala Thr Pro Ala Pro  Pro Gly Val Asp Thr  Pro Pro Pro 
    1010                 1015                 1020             


Ser Arg  Pro Glu Lys Lys Lys  Ala Asp Ile Val Phe  Leu Leu Asp 
    1025                 1030                 1035             


Gly Ser  Ile Asn Phe Arg Arg  Asp Ser Phe Gln Glu  Val Leu Arg 
    1040                 1045                 1050             


Phe Val  Ser Glu Ile Val Asp  Thr Val Tyr Glu Asp  Gly Asp Ser 
    1055                 1060                 1065             


Ile Gln  Val Gly Leu Val Gln  Tyr Asn Ser Asp Pro  Thr Asp Glu 
    1070                 1075                 1080             


Phe Phe  Leu Lys Asp Phe Ser  Thr Lys Arg Gln Ile  Ile Asp Ala 
    1085                 1090                 1095             


Ile Asn  Lys Val Val Tyr Lys  Gly Gly Arg His Ala  Asn Thr Lys 
    1100                 1105                 1110             


Val Gly  Leu Glu His Leu Arg  Val Asn His Phe Val  Pro Glu Ala 
    1115                 1120                 1125             


Gly Ser  Arg Leu Asp Gln Arg  Val Pro Gln Ile Ala  Phe Val Ile 
    1130                 1135                 1140             


Thr Gly  Gly Lys Ser Val Glu  Asp Ala Gln Asp Val  Ser Leu Ala 
    1145                 1150                 1155             


Leu Thr  Gln Arg Gly Val Lys  Val Phe Ala Val Gly  Val Arg Asn 
    1160                 1165                 1170             


Ile Asp  Ser Glu Glu Val Gly  Lys Ile Ala Ser Asn  Ser Ala Thr 
    1175                 1180                 1185             


Ala Phe  Arg Val Gly Asn Val  Gln Glu Leu Ser Glu  Leu Ser Glu 
    1190                 1195                 1200             


Gln Val  Leu Glu Thr Leu His  Asp Ala Met His Glu  Thr Leu Cys 
    1205                 1210                 1215             


Pro Gly  Val Thr Asp Ala Ala  Lys Ala Cys Asn Leu  Asp Val Ile 
    1220                 1225                 1230             


Leu Gly  Phe Asp Gly Ser Arg  Asp Gln Asn Val Phe  Val Ala Gln 
    1235                 1240                 1245             


Lys Gly  Phe Glu Ser Lys Val  Asp Ala Ile Leu Asn  Arg Ile Ser 
    1250                 1255                 1260             


Gln Met  His Arg Val Ser Cys  Ser Gly Gly Arg Ser  Pro Thr Val 
    1265                 1270                 1275             


Arg Val  Ser Val Val Ala Asn  Thr Pro Ser Gly Pro  Val Glu Ala 
    1280                 1285                 1290             


Phe Asp  Phe Asp Glu Tyr Gln  Pro Glu Met Leu Glu  Lys Phe Arg 
    1295                 1300                 1305             


Asn Met  Arg Ser Gln His Pro  Tyr Val Leu Thr Glu  Asp Thr Leu 
    1310                 1315                 1320             


Lys Val  Tyr Leu Asn Lys Phe  Arg Gln Ser Ser Pro  Asp Ser Val 
    1325                 1330                 1335             


Lys Val  Val Ile His Phe Thr  Asp Gly Ala Asp Gly  Asp Leu Ala 
    1340                 1345                 1350             


Asp Leu  His Arg Ala Ser Glu  Asn Leu Arg Gln Glu  Gly Val Arg 
    1355                 1360                 1365             


Ala Leu  Ile Leu Val Gly Leu  Glu Arg Val Val Asn  Leu Glu Arg 
    1370                 1375                 1380             


Leu Met  His Leu Glu Phe Gly  Arg Gly Phe Met Tyr  Asp Arg Pro 
    1385                 1390                 1395             


Leu Arg  Leu Asn Leu Leu Asp  Leu Asp Tyr Glu Leu  Ala Glu Gln 
    1400                 1405                 1410             


Leu Asp  Asn Ile Ala Glu Lys  Ala Cys Cys Gly Val  Pro Cys Lys 
    1415                 1420                 1425             


Cys Ser  Gly Gln Arg Gly Asp  Arg Gly Pro Ile Gly  Ser Ile Gly 
    1430                 1435                 1440             


Pro Lys  Gly Ile Pro Gly Glu  Asp Gly Tyr Arg Gly  Tyr Pro Gly 
    1445                 1450                 1455             


Asp Glu  Gly Gly Pro Gly Glu  Arg Gly Pro Pro Gly  Val Asn Gly 
    1460                 1465                 1470             


Thr Gln  Gly Phe Gln Gly Cys  Pro Gly Gln Arg Gly  Val Lys Gly 
    1475                 1480                 1485             


Ser Arg  Gly Phe Pro Gly Glu  Lys Gly Glu Val Gly  Glu Ile Gly 
    1490                 1495                 1500             


Leu Asp  Gly Leu Asp Gly Glu  Asp Gly Asp Lys Gly  Leu Pro Gly 
    1505                 1510                 1515             


Ser Ser  Gly Glu Lys Gly Asn  Pro Gly Arg Arg Gly  Asp Lys Gly 
    1520                 1525                 1530             


Pro Arg  Gly Glu Lys Gly Glu  Arg Gly Asp Val Gly  Ile Arg Gly 
    1535                 1540                 1545             


Asp Pro  Gly Asn Pro Gly Gln  Asp Ser Gln Glu Arg  Gly Pro Lys 
    1550                 1555                 1560             


Gly Glu  Thr Gly Asp Leu Gly  Pro Met Gly Val Pro  Gly Arg Asp 
    1565                 1570                 1575             


Gly Val  Pro Gly Gly Pro Gly  Glu Thr Gly Lys Asn  Gly Gly Phe 
    1580                 1585                 1590             


Gly Arg  Arg Gly Pro Pro Gly  Ala Lys Gly Asn Lys  Gly Gly Pro 
    1595                 1600                 1605             


Gly Gln  Pro Gly Phe Glu Gly  Glu Gln Gly Thr Arg  Gly Ala Gln 
    1610                 1615                 1620             


Gly Pro  Ala Gly Pro Ala Gly  Pro Pro Gly Leu Ile  Gly Glu Gln 
    1625                 1630                 1635             


Gly Ile  Ser Gly Pro Arg Gly  Ser Gly Gly Ala Ala  Gly Ala Pro 
    1640                 1645                 1650             


Gly Glu  Arg Gly Arg Thr Gly  Pro Leu Gly Arg Lys  Gly Glu Pro 
    1655                 1660                 1665             


Gly Glu  Pro Gly Pro Lys Gly  Gly Ile Gly Asn Arg  Gly Pro Arg 
    1670                 1675                 1680             


Gly Glu  Thr Gly Asp Asp Gly  Arg Asp Gly Val Gly  Ser Glu Gly 
    1685                 1690                 1695             


Arg Arg  Gly Lys Lys Gly Glu  Arg Gly Phe Pro Gly  Tyr Pro Gly 
    1700                 1705                 1710             


Pro Lys  Gly Asn Pro Gly Glu  Pro Gly Leu Asn Gly  Thr Thr Gly 
    1715                 1720                 1725             


Pro Lys  Gly Ile Arg Gly Arg  Arg Gly Asn Ser Gly  Pro Pro Gly 
    1730                 1735                 1740             


Ile Val  Gly Gln Lys Gly Asp  Pro Gly Tyr Pro Gly  Pro Ala Gly 
    1745                 1750                 1755             


Pro Lys  Gly Asn Arg Gly Asp  Ser Ile Asp Gln Cys  Ala Leu Ile 
    1760                 1765                 1770             


Gln Ser  Ile Lys Asp Lys Cys  Pro Cys Cys Tyr Gly  Pro Leu Glu 
    1775                 1780                 1785             


Cys Pro  Val Phe Pro Thr Glu  Leu Ala Phe Ala Leu  Asp Thr Ser 
    1790                 1795                 1800             


Glu Gly  Val Asn Gln Asp Thr  Phe Gly Arg Met Arg  Asp Val Val 
    1805                 1810                 1815             


Leu Ser  Ile Val Asn Asp Leu  Thr Ile Ala Glu Ser  Asn Cys Pro 
    1820                 1825                 1830             


Arg Gly  Ala Arg Val Ala Val  Val Thr Tyr Asn Asn  Glu Val Thr 
    1835                 1840                 1845             


Thr Glu  Ile Arg Phe Ala Asp  Ser Lys Arg Lys Ser  Val Leu Leu 
    1850                 1855                 1860             


Asp Lys  Ile Lys Asn Leu Gln  Val Ala Leu Thr Ser  Lys Gln Gln 
    1865                 1870                 1875             


Ser Leu  Glu Thr Ala Met Ser  Phe Val Ala Arg Asn  Thr Phe Lys 
    1880                 1885                 1890             


Arg Val  Arg Asn Gly Phe Leu  Met Arg Lys Val Ala  Val Phe Phe 
    1895                 1900                 1905             


Ser Asn  Thr Pro Thr Arg Ala  Ser Pro Gln Leu Arg  Glu Ala Val 
    1910                 1915                 1920             


Leu Lys  Leu Ser Asp Ala Gly  Ile Thr Pro Leu Phe  Leu Thr Arg 
    1925                 1930                 1935             


Gln Glu  Asp Arg Gln Leu Ile  Asn Ala Leu Gln Ile  Asn Asn Thr 
    1940                 1945                 1950             


Ala Val  Gly His Ala Leu Val  Leu Pro Ala Gly Arg  Asp Leu Thr 
    1955                 1960                 1965             


Asp Phe  Leu Glu Asn Val Leu  Thr Cys His Val Cys  Leu Asp Ile 
    1970                 1975                 1980             


Cys Asn  Ile Asp Pro Ser Cys  Gly Phe Gly Ser Trp  Arg Pro Ser 
    1985                 1990                 1995             


Phe Arg  Asp Arg Arg Ala Ala  Gly Ser Asp Val Asp  Ile Asp Met 
    2000                 2005                 2010             


Ala Phe  Ile Leu Asp Ser Ala  Glu Thr Thr Thr Leu  Phe Gln Phe 
    2015                 2020                 2025             


Asn Glu  Met Lys Lys Tyr Ile  Ala Tyr Leu Val Arg  Gln Leu Asp 
    2030                 2035                 2040             


Met Ser  Pro Asp Pro Lys Ala  Ser Gln His Phe Ala  Arg Val Ala 
    2045                 2050                 2055             


Val Val  Gln His Ala Pro Ser  Glu Ser Val Asp Asn  Ala Ser Met 
    2060                 2065                 2070             


Pro Pro  Val Lys Val Glu Phe  Ser Leu Thr Asp Tyr  Gly Ser Lys 
    2075                 2080                 2085             


Glu Lys  Leu Val Asp Phe Leu  Ser Arg Gly Met Thr  Gln Leu Gln 
    2090                 2095                 2100             


Gly Thr  Arg Ala Leu Gly Ser  Ala Ile Glu Tyr Thr  Ile Glu Asn 
    2105                 2110                 2115             


Val Phe  Glu Ser Ala Pro Asn  Pro Arg Asp Leu Lys  Ile Val Val 
    2120                 2125                 2130             


Leu Met  Leu Thr Gly Glu Val  Pro Glu Gln Gln Leu  Glu Glu Ala 
    2135                 2140                 2145             


Gln Arg  Val Ile Leu Gln Ala  Lys Cys Lys Gly Tyr  Phe Phe Val 
    2150                 2155                 2160             


Val Leu  Gly Ile Gly Arg Lys  Val Asn Ile Lys Glu  Val Tyr Thr 
    2165                 2170                 2175             


Phe Ala  Ser Glu Pro Asn Asp  Val Phe Phe Lys Leu  Val Asp Lys 
    2180                 2185                 2190             


Ser Thr  Glu Leu Asn Glu Glu  Pro Leu Met Arg Phe  Gly Arg Leu 
    2195                 2200                 2205             


Leu Pro  Ser Phe Val Ser Ser  Glu Asn Ala Phe Tyr  Leu Ser Pro 
    2210                 2215                 2220             


Asp Ile  Arg Lys Gln Cys Asp  Trp Phe Gln Gly Asp  Gln Pro Thr 
    2225                 2230                 2235             


Lys Asn  Leu Val Lys Phe Gly  His Lys Gln Val Asn  Val Pro Asn 
    2240                 2245                 2250             


Asn Val  Thr Ser Ser Pro Thr  Ser Asn Pro Val Thr  Thr Thr Lys 
    2255                 2260                 2265             


Pro Val  Thr Thr Thr Lys Pro  Val Thr Thr Thr Thr  Lys Pro Val 
    2270                 2275                 2280             


Thr Thr  Thr Thr Lys Pro Val  Thr Ile Ile Asn Gln  Pro Ser Val 
    2285                 2290                 2295             


Lys Pro  Ala Ala Ala Lys Pro  Ala Pro Ala Lys Pro  Val Ala Ala 
    2300                 2305                 2310             


Lys Pro  Val Ala Thr Lys Met  Ala Thr Val Arg Pro  Pro Val Ala 
    2315                 2320                 2325             


Val Lys  Pro Ala Thr Ala Ala  Lys Pro Val Ala Ala  Lys Pro Ala 
    2330                 2335                 2340             


Ala Val  Arg Pro Pro Ala Ala  Ala Ala Ala Lys Pro  Val Ala Thr 
    2345                 2350                 2355             


Lys Pro  Glu Val Pro Arg Pro  Gln Ala Ala Lys Pro  Ala Ala Thr 
    2360                 2365                 2370             


Lys Pro  Ala Thr Thr Lys Pro  Met Val Lys Met Ser  Arg Glu Val 
    2375                 2380                 2385             


Gln Val  Phe Glu Ile Thr Glu  Asn Ser Ala Lys Leu  His Trp Glu 
    2390                 2395                 2400             


Arg Ala  Glu Pro Pro Gly Pro  Tyr Phe Tyr Asp Leu  Thr Val Thr 
    2405                 2410                 2415             


Ser Ala  His Asp Gln Ser Leu  Val Leu Lys Gln Asn  Leu Thr Val 
    2420                 2425                 2430             


Thr Asp  Arg Val Ile Gly Gly  Leu Leu Ala Gly Gln  Thr Tyr His 
    2435                 2440                 2445             


Val Ala  Val Val Cys Tyr Leu  Arg Ser Gln Val Arg  Ala Thr Tyr 
    2450                 2455                 2460             


His Gly  Ser Phe Ser Thr Lys  Lys Ser Gln Pro Pro  Pro Pro Gln 
    2465                 2470                 2475             


Pro Ala  Arg Ser Ala Ser Ser  Ser Thr Ile Asn Leu  Met Val Ser 
    2480                 2485                 2490             


Thr Glu  Pro Leu Ala Leu Thr  Glu Thr Asp Ile Cys  Lys Leu Pro 
    2495                 2500                 2505             


Lys Asp  Glu Gly Thr Cys Arg  Asp Phe Ile Leu Lys  Trp Tyr Tyr 
    2510                 2515                 2520             


Asp Pro  Asn Thr Lys Ser Cys  Ala Arg Phe Trp Tyr  Gly Gly Cys 
    2525                 2530                 2535             


Gly Gly  Asn Glu Asn Lys Phe  Gly Ser Gln Lys Glu  Cys Glu Lys 
    2540                 2545                 2550             


Val Cys  Ala Pro Val Leu Ala  Lys Pro Gly Val Ile  Ser Val Met 
    2555                 2560                 2565             


Gly Thr  
    2570 


<210>  117
<211>  1237
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Collagen type VI, alpha 3 Variant 5

<400>  117

Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe 
1               5                   10                  15      


Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Ala Gln 
            20                  25                  30          


Asp Ser Ala Asp Ile Ile Phe Leu Ile Asp Gly Ser Asn Asn Thr Gly 
        35                  40                  45              


Ser Val Asn Phe Ala Val Ile Leu Asp Phe Leu Val Asn Leu Leu Glu 
    50                  55                  60                  


Lys Leu Pro Ile Gly Thr Gln Gln Ile Arg Val Gly Val Val Gln Phe 
65                  70                  75                  80  


Ser Asp Glu Pro Arg Thr Met Phe Ser Leu Asp Thr Tyr Ser Thr Lys 
                85                  90                  95      


Ala Gln Val Leu Gly Ala Val Lys Ala Leu Gly Phe Ala Gly Gly Glu 
            100                 105                 110         


Leu Ala Asn Ile Gly Leu Ala Leu Asp Phe Val Val Glu Asn His Phe 
        115                 120                 125             


Thr Arg Ala Gly Gly Ser Arg Val Glu Glu Gly Val Pro Gln Val Leu 
    130                 135                 140                 


Val Leu Ile Ser Ala Gly Pro Ser Ser Asp Glu Ile Arg Tyr Gly Val 
145                 150                 155                 160 


Val Ala Leu Lys Gln Ala Ser Val Phe Ser Phe Gly Leu Gly Ala Gln 
                165                 170                 175     


Ala Ala Ser Arg Ala Glu Leu Gln His Ile Ala Thr Asp Asp Asn Leu 
            180                 185                 190         


Val Phe Thr Val Pro Glu Phe Arg Ser Phe Gly Asp Leu Gln Glu Lys 
        195                 200                 205             


Leu Leu Pro Tyr Ile Val Gly Val Ala Gln Arg His Ile Val Leu Lys 
    210                 215                 220                 


Pro Pro Thr Ile Val Thr Gln Val Ile Glu Val Asn Lys Arg Asp Ile 
225                 230                 235                 240 


Val Phe Leu Val Asp Gly Ser Ser Ala Leu Gly Leu Ala Asn Phe Asn 
                245                 250                 255     


Ala Ile Arg Asp Phe Ile Ala Lys Val Ile Gln Arg Leu Glu Ile Gly 
            260                 265                 270         


Gln Asp Leu Ile Gln Val Ala Val Ala Gln Tyr Ala Asp Thr Val Arg 
        275                 280                 285             


Pro Glu Phe Tyr Phe Asn Thr His Pro Thr Lys Arg Glu Val Ile Thr 
    290                 295                 300                 


Ala Val Arg Lys Met Lys Pro Leu Asp Gly Ser Ala Leu Tyr Thr Gly 
305                 310                 315                 320 


Ser Ala Leu Asp Phe Val Arg Asn Asn Leu Phe Thr Ser Ser Ala Gly 
                325                 330                 335     


Tyr Arg Ala Ala Glu Gly Ile Pro Lys Leu Leu Val Leu Ile Thr Gly 
            340                 345                 350         


Gly Lys Ser Leu Asp Glu Ile Ser Gln Pro Ala Gln Glu Leu Lys Arg 
        355                 360                 365             


Ser Ser Ile Met Ala Phe Ala Ile Gly Asn Lys Gly Ala Asp Gln Ala 
    370                 375                 380                 


Glu Leu Glu Glu Ile Ala Phe Asp Ser Ser Leu Val Phe Ile Pro Ala 
385                 390                 395                 400 


Glu Phe Arg Ala Ala Pro Leu Gln Gly Met Leu Pro Gly Leu Leu Ala 
                405                 410                 415     


Pro Leu Arg Thr Leu Ser Gly Thr Pro Glu Val His Ser Asn Lys Arg 
            420                 425                 430         


Asp Ile Ile Phe Leu Leu Asp Gly Ser Ala Asn Val Gly Lys Thr Asn 
        435                 440                 445             


Phe Pro Tyr Val Arg Asp Phe Val Met Asn Leu Val Asn Ser Leu Asp 
    450                 455                 460                 


Ile Gly Asn Asp Asn Ile Arg Val Gly Leu Val Gln Phe Ser Asp Thr 
465                 470                 475                 480 


Pro Val Thr Glu Phe Ser Leu Asn Thr Tyr Gln Thr Lys Ser Asp Ile 
                485                 490                 495     


Leu Gly His Leu Arg Gln Leu Gln Leu Gln Gly Gly Ser Gly Leu Asn 
            500                 505                 510         


Thr Gly Ser Ala Leu Ser Tyr Val Tyr Ala Asn His Phe Thr Glu Ala 
        515                 520                 525             


Gly Gly Ser Arg Ile Arg Glu His Val Pro Gln Leu Leu Leu Leu Leu 
    530                 535                 540                 


Thr Ala Gly Gln Ser Glu Asp Ser Tyr Leu Gln Ala Ala Asn Ala Leu 
545                 550                 555                 560 


Thr Arg Ala Gly Ile Leu Thr Phe Cys Val Gly Ala Ser Gln Ala Asn 
                565                 570                 575     


Lys Ala Glu Leu Glu Gln Ile Ala Phe Asn Pro Ser Leu Val Tyr Leu 
            580                 585                 590         


Met Asp Asp Phe Ser Ser Leu Pro Ala Leu Pro Gln Gln Leu Ile Gln 
        595                 600                 605             


Pro Leu Thr Thr Tyr Val Ser Gly Gly Val Glu Glu Val Pro Leu Ala 
    610                 615                 620                 


Gln Pro Glu Ser Lys Arg Asp Ile Leu Phe Leu Phe Asp Gly Ser Ala 
625                 630                 635                 640 


Asn Leu Val Gly Gln Phe Pro Val Val Arg Asp Phe Leu Tyr Lys Ile 
                645                 650                 655     


Ile Asp Glu Leu Asn Val Lys Pro Glu Gly Thr Arg Ile Ala Val Ala 
            660                 665                 670         


Gln Tyr Ser Asp Asp Val Lys Val Glu Ser Arg Phe Asp Glu His Gln 
        675                 680                 685             


Ser Lys Pro Glu Ile Leu Asn Leu Val Lys Arg Met Lys Ile Lys Thr 
    690                 695                 700                 


Gly Lys Ala Leu Asn Leu Gly Tyr Ala Leu Asp Tyr Ala Gln Arg Tyr 
705                 710                 715                 720 


Ile Phe Val Lys Ser Ala Gly Ser Arg Ile Glu Asp Gly Val Leu Gln 
                725                 730                 735     


Phe Leu Val Leu Leu Val Ala Gly Arg Ser Ser Asp Arg Val Asp Gly 
            740                 745                 750         


Pro Ala Ser Asn Leu Lys Gln Ser Gly Val Val Pro Phe Ile Phe Gln 
        755                 760                 765             


Ala Lys Asn Ala Asp Pro Ala Glu Leu Glu Gln Ile Val Leu Ser Pro 
    770                 775                 780                 


Ala Phe Ile Leu Ala Ala Glu Ser Leu Pro Lys Ile Gly Asp Leu His 
785                 790                 795                 800 


Pro Gln Ile Val Asn Leu Leu Lys Ser Val His Asn Gly Ala Pro Ala 
                805                 810                 815     


Pro Val Ser Gly Glu Lys Asp Val Val Phe Leu Leu Asp Gly Ser Glu 
            820                 825                 830         


Gly Val Arg Ser Gly Phe Pro Leu Leu Lys Glu Phe Val Gln Arg Val 
        835                 840                 845             


Val Glu Ser Leu Asp Val Gly Gln Asp Arg Val Arg Val Ala Val Val 
    850                 855                 860                 


Gln Tyr Ser Asp Arg Thr Arg Pro Glu Phe Tyr Leu Asn Ser Tyr Met 
865                 870                 875                 880 


Asn Lys Gln Asp Val Val Asn Ala Val Arg Gln Leu Thr Leu Leu Gly 
                885                 890                 895     


Gly Pro Thr Pro Asn Thr Gly Ala Ala Leu Glu Phe Val Leu Arg Asn 
            900                 905                 910         


Ile Leu Val Ser Ser Ala Gly Ser Arg Ile Thr Glu Gly Val Pro Gln 
        915                 920                 925             


Leu Leu Ile Val Leu Thr Ala Asp Arg Ser Gly Asp Asp Val Arg Asn 
    930                 935                 940                 


Pro Ser Val Val Val Lys Arg Gly Gly Ala Val Pro Ile Gly Ile Gly 
945                 950                 955                 960 


Ile Gly Asn Ala Asp Ile Thr Glu Met Gln Thr Ile Ser Phe Ile Pro 
                965                 970                 975     


Asp Phe Ala Val Ala Ile Pro Thr Phe Arg Gln Leu Gly Thr Val Gln 
            980                 985                 990         


Gln Val Ile Ser Glu Arg Val Thr  Gln Leu Thr Arg Glu  Glu Leu Ser 
        995                 1000                 1005             


Arg Leu  Gln Pro Val Leu Gln  Pro Leu Pro Ser Pro  Gly Val Gly 
    1010                 1015                 1020             


Gly Lys  Arg Asp Val Val Phe  Leu Ile Asp Gly Ser  Gln Ser Ala 
    1025                 1030                 1035             


Gly Pro  Glu Phe Gln Tyr Val  Arg Thr Leu Ile Glu  Arg Leu Val 
    1040                 1045                 1050             


Asp Tyr  Leu Asp Val Gly Phe  Asp Thr Thr Arg Val  Ala Val Ile 
    1055                 1060                 1065             


Gln Phe  Ser Asp Asp Pro Lys  Val Glu Phe Leu Leu  Asn Ala His 
    1070                 1075                 1080             


Ser Ser  Lys Asp Glu Val Gln  Asn Ala Val Gln Arg  Leu Arg Pro 
    1085                 1090                 1095             


Lys Gly  Gly Arg Gln Ile Asn  Val Gly Asn Ala Leu  Glu Tyr Val 
    1100                 1105                 1110             


Ser Arg  Asn Ile Phe Lys Arg  Pro Leu Gly Ser Arg  Ile Glu Glu 
    1115                 1120                 1125             


Gly Val  Pro Gln Phe Leu Val  Leu Ile Ser Ser Gly  Lys Ser Asp 
    1130                 1135                 1140             


Asp Glu  Val Asp Asp Pro Ala  Val Glu Leu Lys Gln  Phe Gly Val 
    1145                 1150                 1155             


Ala Pro  Phe Thr Ile Ala Arg  Asn Ala Asp Gln Glu  Glu Leu Val 
    1160                 1165                 1170             


Lys Ile  Ser Leu Ser Pro Glu  Tyr Val Phe Ser Val  Ser Thr Phe 
    1175                 1180                 1185             


Arg Glu  Leu Pro Ser Leu Glu  Gln Lys Leu Leu Thr  Pro Ile Thr 
    1190                 1195                 1200             


Thr Leu  Thr Ser Glu Gln Ile  Gln Lys Leu Leu Ala  Ser Thr Arg 
    1205                 1210                 1215             


Tyr Pro  Pro Pro Gly Glu Met  Gly Ala Ser Glu Val  Leu Leu Gly 
    1220                 1225                 1230             


Ala Phe  Ser Ile 
    1235         


<210>  118
<211>  1036
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Collagen type VI, alpha 3 Variant 6

<400>  118

Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe 
1               5                   10                  15      


Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Val Ile 
            20                  25                  30          


Glu Val Asn Lys Arg Asp Ile Val Phe Leu Val Asp Gly Ser Ser Ala 
        35                  40                  45              


Leu Gly Leu Ala Asn Phe Asn Ala Ile Arg Asp Phe Ile Ala Lys Val 
    50                  55                  60                  


Ile Gln Arg Leu Glu Ile Gly Gln Asp Leu Ile Gln Val Ala Val Ala 
65                  70                  75                  80  


Gln Tyr Ala Asp Thr Val Arg Pro Glu Phe Tyr Phe Asn Thr His Pro 
                85                  90                  95      


Thr Lys Arg Glu Val Ile Thr Ala Val Arg Lys Met Lys Pro Leu Asp 
            100                 105                 110         


Gly Ser Ala Leu Tyr Thr Gly Ser Ala Leu Asp Phe Val Arg Asn Asn 
        115                 120                 125             


Leu Phe Thr Ser Ser Ala Gly Tyr Arg Ala Ala Glu Gly Ile Pro Lys 
    130                 135                 140                 


Leu Leu Val Leu Ile Thr Gly Gly Lys Ser Leu Asp Glu Ile Ser Gln 
145                 150                 155                 160 


Pro Ala Gln Glu Leu Lys Arg Ser Ser Ile Met Ala Phe Ala Ile Gly 
                165                 170                 175     


Asn Lys Gly Ala Asp Gln Ala Glu Leu Glu Glu Ile Ala Phe Asp Ser 
            180                 185                 190         


Ser Leu Val Phe Ile Pro Ala Glu Phe Arg Ala Ala Pro Leu Gln Gly 
        195                 200                 205             


Met Leu Pro Gly Leu Leu Ala Pro Leu Arg Thr Leu Ser Gly Thr Pro 
    210                 215                 220                 


Glu Val His Ser Asn Lys Arg Asp Ile Ile Phe Leu Leu Asp Gly Ser 
225                 230                 235                 240 


Ala Asn Val Gly Lys Thr Asn Phe Pro Tyr Val Arg Asp Phe Val Met 
                245                 250                 255     


Asn Leu Val Asn Ser Leu Asp Ile Gly Asn Asp Asn Ile Arg Val Gly 
            260                 265                 270         


Leu Val Gln Phe Ser Asp Thr Pro Val Thr Glu Phe Ser Leu Asn Thr 
        275                 280                 285             


Tyr Gln Thr Lys Ser Asp Ile Leu Gly His Leu Arg Gln Leu Gln Leu 
    290                 295                 300                 


Gln Gly Gly Ser Gly Leu Asn Thr Gly Ser Ala Leu Ser Tyr Val Tyr 
305                 310                 315                 320 


Ala Asn His Phe Thr Glu Ala Gly Gly Ser Arg Ile Arg Glu His Val 
                325                 330                 335     


Pro Gln Leu Leu Leu Leu Leu Thr Ala Gly Gln Ser Glu Asp Ser Tyr 
            340                 345                 350         


Leu Gln Ala Ala Asn Ala Leu Thr Arg Ala Gly Ile Leu Thr Phe Cys 
        355                 360                 365             


Val Gly Ala Ser Gln Ala Asn Lys Ala Glu Leu Glu Gln Ile Ala Phe 
    370                 375                 380                 


Asn Pro Ser Leu Val Tyr Leu Met Asp Asp Phe Ser Ser Leu Pro Ala 
385                 390                 395                 400 


Leu Pro Gln Gln Leu Ile Gln Pro Leu Thr Thr Tyr Val Ser Gly Gly 
                405                 410                 415     


Val Glu Glu Val Pro Leu Ala Gln Pro Glu Ser Lys Arg Asp Ile Leu 
            420                 425                 430         


Phe Leu Phe Asp Gly Ser Ala Asn Leu Val Gly Gln Phe Pro Val Val 
        435                 440                 445             


Arg Asp Phe Leu Tyr Lys Ile Ile Asp Glu Leu Asn Val Lys Pro Glu 
    450                 455                 460                 


Gly Thr Arg Ile Ala Val Ala Gln Tyr Ser Asp Asp Val Lys Val Glu 
465                 470                 475                 480 


Ser Arg Phe Asp Glu His Gln Ser Lys Pro Glu Ile Leu Asn Leu Val 
                485                 490                 495     


Lys Arg Met Lys Ile Lys Thr Gly Lys Ala Leu Asn Leu Gly Tyr Ala 
            500                 505                 510         


Leu Asp Tyr Ala Gln Arg Tyr Ile Phe Val Lys Ser Ala Gly Ser Arg 
        515                 520                 525             


Ile Glu Asp Gly Val Leu Gln Phe Leu Val Leu Leu Val Ala Gly Arg 
    530                 535                 540                 


Ser Ser Asp Arg Val Asp Gly Pro Ala Ser Asn Leu Lys Gln Ser Gly 
545                 550                 555                 560 


Val Val Pro Phe Ile Phe Gln Ala Lys Asn Ala Asp Pro Ala Glu Leu 
                565                 570                 575     


Glu Gln Ile Val Leu Ser Pro Ala Phe Ile Leu Ala Ala Glu Ser Leu 
            580                 585                 590         


Pro Lys Ile Gly Asp Leu His Pro Gln Ile Val Asn Leu Leu Lys Ser 
        595                 600                 605             


Val His Asn Gly Ala Pro Ala Pro Val Ser Gly Glu Lys Asp Val Val 
    610                 615                 620                 


Phe Leu Leu Asp Gly Ser Glu Gly Val Arg Ser Gly Phe Pro Leu Leu 
625                 630                 635                 640 


Lys Glu Phe Val Gln Arg Val Val Glu Ser Leu Asp Val Gly Gln Asp 
                645                 650                 655     


Arg Val Arg Val Ala Val Val Gln Tyr Ser Asp Arg Thr Arg Pro Glu 
            660                 665                 670         


Phe Tyr Leu Asn Ser Tyr Met Asn Lys Gln Asp Val Val Asn Ala Val 
        675                 680                 685             


Arg Gln Leu Thr Leu Leu Gly Gly Pro Thr Pro Asn Thr Gly Ala Ala 
    690                 695                 700                 


Leu Glu Phe Val Leu Arg Asn Ile Leu Val Ser Ser Ala Gly Ser Arg 
705                 710                 715                 720 


Ile Thr Glu Gly Val Pro Gln Leu Leu Ile Val Leu Thr Ala Asp Arg 
                725                 730                 735     


Ser Gly Asp Asp Val Arg Asn Pro Ser Val Val Val Lys Arg Gly Gly 
            740                 745                 750         


Ala Val Pro Ile Gly Ile Gly Ile Gly Asn Ala Asp Ile Thr Glu Met 
        755                 760                 765             


Gln Thr Ile Ser Phe Ile Pro Asp Phe Ala Val Ala Ile Pro Thr Phe 
    770                 775                 780                 


Arg Gln Leu Gly Thr Val Gln Gln Val Ile Ser Glu Arg Val Thr Gln 
785                 790                 795                 800 


Leu Thr Arg Glu Glu Leu Ser Arg Leu Gln Pro Val Leu Gln Pro Leu 
                805                 810                 815     


Pro Ser Pro Gly Val Gly Gly Lys Arg Asp Val Val Phe Leu Ile Asp 
            820                 825                 830         


Gly Ser Gln Ser Ala Gly Pro Glu Phe Gln Tyr Val Arg Thr Leu Ile 
        835                 840                 845             


Glu Arg Leu Val Asp Tyr Leu Asp Val Gly Phe Asp Thr Thr Arg Val 
    850                 855                 860                 


Ala Val Ile Gln Phe Ser Asp Asp Pro Lys Val Glu Phe Leu Leu Asn 
865                 870                 875                 880 


Ala His Ser Ser Lys Asp Glu Val Gln Asn Ala Val Gln Arg Leu Arg 
                885                 890                 895     


Pro Lys Gly Gly Arg Gln Ile Asn Val Gly Asn Ala Leu Glu Tyr Val 
            900                 905                 910         


Ser Arg Asn Ile Phe Lys Arg Pro Leu Gly Ser Arg Ile Glu Glu Gly 
        915                 920                 925             


Val Pro Gln Phe Leu Val Leu Ile Ser Ser Gly Lys Ser Asp Asp Glu 
    930                 935                 940                 


Val Asp Asp Pro Ala Val Glu Leu Lys Gln Phe Gly Val Ala Pro Phe 
945                 950                 955                 960 


Thr Ile Ala Arg Asn Ala Asp Gln Glu Glu Leu Val Lys Ile Ser Leu 
                965                 970                 975     


Ser Pro Glu Tyr Val Phe Ser Val Ser Thr Phe Arg Glu Leu Pro Ser 
            980                 985                 990         


Leu Glu Gln Lys Leu Leu Thr Pro  Ile Thr Thr Leu Thr  Ser Glu Gln 
        995                 1000                 1005             


Ile Gln  Lys Leu Leu Ala Ser  Thr Arg Tyr Pro Pro  Pro Gly Glu 
    1010                 1015                 1020             


Met Gly  Ala Ser Glu Val Leu  Leu Gly Ala Phe Ser  Ile 
    1025                 1030                 1035     


<210>  119
<211>  2569
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Collagen type VI, alpha 3 Variant 7

<400>  119

Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe 
1               5                   10                  15      


Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Val Ile 
            20                  25                  30          


Glu Val Asn Lys Arg Asp Ile Val Phe Leu Val Asp Gly Ser Ser Ala 
        35                  40                  45              


Leu Gly Leu Ala Asn Phe Asn Ala Ile Arg Asp Phe Ile Ala Lys Val 
    50                  55                  60                  


Ile Gln Arg Leu Glu Ile Gly Gln Asp Leu Ile Gln Val Ala Val Ala 
65                  70                  75                  80  


Gln Tyr Ala Asp Thr Val Arg Pro Glu Phe Tyr Phe Asn Thr His Pro 
                85                  90                  95      


Thr Lys Arg Glu Val Ile Thr Ala Val Arg Lys Met Lys Pro Leu Asp 
            100                 105                 110         


Gly Ser Ala Leu Tyr Thr Gly Ser Ala Leu Asp Phe Val Arg Asn Asn 
        115                 120                 125             


Leu Phe Thr Ser Ser Ala Gly Tyr Arg Ala Ala Glu Gly Ile Pro Lys 
    130                 135                 140                 


Leu Leu Val Leu Ile Thr Gly Gly Lys Ser Leu Asp Glu Ile Ser Gln 
145                 150                 155                 160 


Pro Ala Gln Glu Leu Lys Arg Ser Ser Ile Met Ala Phe Ala Ile Gly 
                165                 170                 175     


Asn Lys Gly Ala Asp Gln Ala Glu Leu Glu Glu Ile Ala Phe Asp Ser 
            180                 185                 190         


Ser Leu Val Phe Ile Pro Ala Glu Phe Arg Ala Ala Pro Leu Gln Gly 
        195                 200                 205             


Met Leu Pro Gly Leu Leu Ala Pro Leu Arg Thr Leu Ser Gly Thr Pro 
    210                 215                 220                 


Glu Glu Ser Lys Arg Asp Ile Leu Phe Leu Phe Asp Gly Ser Ala Asn 
225                 230                 235                 240 


Leu Val Gly Gln Phe Pro Val Val Arg Asp Phe Leu Tyr Lys Ile Ile 
                245                 250                 255     


Asp Glu Leu Asn Val Lys Pro Glu Gly Thr Arg Ile Ala Val Ala Gln 
            260                 265                 270         


Tyr Ser Asp Asp Val Lys Val Glu Ser Arg Phe Asp Glu His Gln Ser 
        275                 280                 285             


Lys Pro Glu Ile Leu Asn Leu Val Lys Arg Met Lys Ile Lys Thr Gly 
    290                 295                 300                 


Lys Ala Leu Asn Leu Gly Tyr Ala Leu Asp Tyr Ala Gln Arg Tyr Ile 
305                 310                 315                 320 


Phe Val Lys Ser Ala Gly Ser Arg Ile Glu Asp Gly Val Leu Gln Phe 
                325                 330                 335     


Leu Val Leu Leu Val Ala Gly Arg Ser Ser Asp Arg Val Asp Gly Pro 
            340                 345                 350         


Ala Ser Asn Leu Lys Gln Ser Gly Val Val Pro Phe Ile Phe Gln Ala 
        355                 360                 365             


Lys Asn Ala Asp Pro Ala Glu Leu Glu Gln Ile Val Leu Ser Pro Ala 
    370                 375                 380                 


Phe Ile Leu Ala Ala Glu Ser Leu Pro Lys Ile Gly Asp Leu His Pro 
385                 390                 395                 400 


Gln Ile Val Asn Leu Leu Lys Ser Val His Asn Gly Ala Pro Ala Pro 
                405                 410                 415     


Val Ser Gly Glu Lys Asp Val Val Phe Leu Leu Asp Gly Ser Glu Gly 
            420                 425                 430         


Val Arg Ser Gly Phe Pro Leu Leu Lys Glu Phe Val Gln Arg Val Val 
        435                 440                 445             


Glu Ser Leu Asp Val Gly Gln Asp Arg Val Arg Val Ala Val Val Gln 
    450                 455                 460                 


Tyr Ser Asp Arg Thr Arg Pro Glu Phe Tyr Leu Asn Ser Tyr Met Asn 
465                 470                 475                 480 


Lys Gln Asp Val Val Asn Ala Val Arg Gln Leu Thr Leu Leu Gly Gly 
                485                 490                 495     


Pro Thr Pro Asn Thr Gly Ala Ala Leu Glu Phe Val Leu Arg Asn Ile 
            500                 505                 510         


Leu Val Ser Ser Ala Gly Ser Arg Ile Thr Glu Gly Val Pro Gln Leu 
        515                 520                 525             


Leu Ile Val Leu Thr Ala Asp Arg Ser Gly Asp Asp Val Arg Asn Pro 
    530                 535                 540                 


Ser Val Val Val Lys Arg Gly Gly Ala Val Pro Ile Gly Ile Gly Ile 
545                 550                 555                 560 


Gly Asn Ala Asp Ile Thr Glu Met Gln Thr Ile Ser Phe Ile Pro Asp 
                565                 570                 575     


Phe Ala Val Ala Ile Pro Thr Phe Arg Gln Leu Gly Thr Val Gln Gln 
            580                 585                 590         


Val Ile Ser Glu Arg Val Thr Gln Leu Thr Arg Glu Glu Leu Ser Arg 
        595                 600                 605             


Leu Gln Pro Val Leu Gln Pro Leu Pro Ser Pro Gly Val Gly Gly Lys 
    610                 615                 620                 


Arg Asp Val Val Phe Leu Ile Asp Gly Ser Gln Ser Ala Gly Pro Glu 
625                 630                 635                 640 


Phe Gln Tyr Val Arg Thr Leu Ile Glu Arg Leu Val Asp Tyr Leu Asp 
                645                 650                 655     


Val Gly Phe Asp Thr Thr Arg Val Ala Val Ile Gln Phe Ser Asp Asp 
            660                 665                 670         


Pro Lys Val Glu Phe Leu Leu Asn Ala His Ser Ser Lys Asp Glu Val 
        675                 680                 685             


Gln Asn Ala Val Gln Arg Leu Arg Pro Lys Gly Gly Arg Gln Ile Asn 
    690                 695                 700                 


Val Gly Asn Ala Leu Glu Tyr Val Ser Arg Asn Ile Phe Lys Arg Pro 
705                 710                 715                 720 


Leu Gly Ser Arg Ile Glu Glu Gly Val Pro Gln Phe Leu Val Leu Ile 
                725                 730                 735     


Ser Ser Gly Lys Ser Asp Asp Glu Val Asp Asp Pro Ala Val Glu Leu 
            740                 745                 750         


Lys Gln Phe Gly Val Ala Pro Phe Thr Ile Ala Arg Asn Ala Asp Gln 
        755                 760                 765             


Glu Glu Leu Val Lys Ile Ser Leu Ser Pro Glu Tyr Val Phe Ser Val 
    770                 775                 780                 


Ser Thr Phe Arg Glu Leu Pro Ser Leu Glu Gln Lys Leu Leu Thr Pro 
785                 790                 795                 800 


Ile Thr Thr Leu Thr Ser Glu Gln Ile Gln Lys Leu Leu Ala Ser Thr 
                805                 810                 815     


Arg Tyr Pro Pro Pro Ala Val Glu Ser Asp Ala Ala Asp Ile Val Phe 
            820                 825                 830         


Leu Ile Asp Ser Ser Glu Gly Val Arg Pro Asp Gly Phe Ala His Ile 
        835                 840                 845             


Arg Asp Phe Val Ser Arg Ile Val Arg Arg Leu Asn Ile Gly Pro Ser 
    850                 855                 860                 


Lys Val Arg Val Gly Val Val Gln Phe Ser Asn Asp Val Phe Pro Glu 
865                 870                 875                 880 


Phe Tyr Leu Lys Thr Tyr Arg Ser Gln Ala Pro Val Leu Asp Ala Ile 
                885                 890                 895     


Arg Arg Leu Arg Leu Arg Gly Gly Ser Pro Leu Asn Thr Gly Lys Ala 
            900                 905                 910         


Leu Glu Phe Val Ala Arg Asn Leu Phe Val Lys Ser Ala Gly Ser Arg 
        915                 920                 925             


Ile Glu Asp Gly Val Pro Gln His Leu Val Leu Val Leu Gly Gly Lys 
    930                 935                 940                 


Ser Gln Asp Asp Val Ser Arg Phe Ala Gln Val Ile Arg Ser Ser Gly 
945                 950                 955                 960 


Ile Val Ser Leu Gly Val Gly Asp Arg Asn Ile Asp Arg Thr Glu Leu 
                965                 970                 975     


Gln Thr Ile Thr Asn Asp Pro Arg Leu Val Phe Thr Val Arg Glu Phe 
            980                 985                 990         


Arg Glu Leu Pro Asn Ile Glu Glu  Arg Ile Met Asn Ser  Phe Gly Pro 
        995                 1000                 1005             


Ser Ala  Ala Thr Pro Ala Pro  Pro Gly Val Asp Thr  Pro Pro Pro 
    1010                 1015                 1020             


Ser Arg  Pro Glu Lys Lys Lys  Ala Asp Ile Val Phe  Leu Leu Asp 
    1025                 1030                 1035             


Gly Ser  Ile Asn Phe Arg Arg  Asp Ser Phe Gln Glu  Val Leu Arg 
    1040                 1045                 1050             


Phe Val  Ser Glu Ile Val Asp  Thr Val Tyr Glu Asp  Gly Asp Ser 
    1055                 1060                 1065             


Ile Gln  Val Gly Leu Val Gln  Tyr Asn Ser Asp Pro  Thr Asp Glu 
    1070                 1075                 1080             


Phe Phe  Leu Lys Asp Phe Ser  Thr Lys Arg Gln Ile  Ile Asp Ala 
    1085                 1090                 1095             


Ile Asn  Lys Val Val Tyr Lys  Gly Gly Arg His Ala  Asn Thr Lys 
    1100                 1105                 1110             


Val Gly  Leu Glu His Leu Arg  Val Asn His Phe Val  Pro Glu Ala 
    1115                 1120                 1125             


Gly Ser  Arg Leu Asp Gln Arg  Val Pro Gln Ile Ala  Phe Val Ile 
    1130                 1135                 1140             


Thr Gly  Gly Lys Ser Val Glu  Asp Ala Gln Asp Val  Ser Leu Ala 
    1145                 1150                 1155             


Leu Thr  Gln Arg Gly Val Lys  Val Phe Ala Val Gly  Val Arg Asn 
    1160                 1165                 1170             


Ile Asp  Ser Glu Glu Val Gly  Lys Ile Ala Ser Asn  Ser Ala Thr 
    1175                 1180                 1185             


Ala Phe  Arg Val Gly Asn Val  Gln Glu Leu Ser Glu  Leu Ser Glu 
    1190                 1195                 1200             


Gln Val  Leu Glu Thr Leu His  Asp Ala Met His Glu  Thr Leu Cys 
    1205                 1210                 1215             


Pro Gly  Val Thr Asp Ala Ala  Lys Ala Cys Asn Leu  Asp Val Ile 
    1220                 1225                 1230             


Leu Gly  Phe Asp Gly Ser Arg  Asp Gln Asn Val Phe  Val Ala Gln 
    1235                 1240                 1245             


Lys Gly  Phe Glu Ser Lys Val  Asp Ala Ile Leu Asn  Arg Ile Ser 
    1250                 1255                 1260             


Gln Met  His Arg Val Ser Cys  Ser Gly Gly Arg Ser  Pro Thr Val 
    1265                 1270                 1275             


Arg Val  Ser Val Val Ala Asn  Thr Pro Ser Gly Pro  Val Glu Ala 
    1280                 1285                 1290             


Phe Asp  Phe Asp Glu Tyr Gln  Pro Glu Met Leu Glu  Lys Phe Arg 
    1295                 1300                 1305             


Asn Met  Arg Ser Gln His Pro  Tyr Val Leu Thr Glu  Asp Thr Leu 
    1310                 1315                 1320             


Lys Val  Tyr Leu Asn Lys Phe  Arg Gln Ser Ser Pro  Asp Ser Val 
    1325                 1330                 1335             


Lys Val  Val Ile His Phe Thr  Asp Gly Ala Asp Gly  Asp Leu Ala 
    1340                 1345                 1350             


Asp Leu  His Arg Ala Ser Glu  Asn Leu Arg Gln Glu  Gly Val Arg 
    1355                 1360                 1365             


Ala Leu  Ile Leu Val Gly Leu  Glu Arg Val Val Asn  Leu Glu Arg 
    1370                 1375                 1380             


Leu Met  His Leu Glu Phe Gly  Arg Gly Phe Met Tyr  Asp Arg Pro 
    1385                 1390                 1395             


Leu Arg  Leu Asn Leu Leu Asp  Leu Asp Tyr Glu Leu  Ala Glu Gln 
    1400                 1405                 1410             


Leu Asp  Asn Ile Ala Glu Lys  Ala Cys Cys Gly Val  Pro Cys Lys 
    1415                 1420                 1425             


Cys Ser  Gly Gln Arg Gly Asp  Arg Gly Pro Ile Gly  Ser Ile Gly 
    1430                 1435                 1440             


Pro Lys  Gly Ile Pro Gly Glu  Asp Gly Tyr Arg Gly  Tyr Pro Gly 
    1445                 1450                 1455             


Asp Glu  Gly Gly Pro Gly Glu  Arg Gly Pro Pro Gly  Val Asn Gly 
    1460                 1465                 1470             


Thr Gln  Gly Phe Gln Gly Cys  Pro Gly Gln Arg Gly  Val Lys Gly 
    1475                 1480                 1485             


Ser Arg  Gly Phe Pro Gly Glu  Lys Gly Glu Val Gly  Glu Ile Gly 
    1490                 1495                 1500             


Leu Asp  Gly Leu Asp Gly Glu  Asp Gly Asp Lys Gly  Leu Pro Gly 
    1505                 1510                 1515             


Ser Ser  Gly Glu Lys Gly Asn  Pro Gly Arg Arg Gly  Asp Lys Gly 
    1520                 1525                 1530             


Pro Arg  Gly Glu Lys Gly Glu  Arg Gly Asp Val Gly  Ile Arg Gly 
    1535                 1540                 1545             


Asp Pro  Gly Asn Pro Gly Gln  Asp Ser Gln Glu Arg  Gly Pro Lys 
    1550                 1555                 1560             


Gly Glu  Thr Gly Asp Leu Gly  Pro Met Gly Val Pro  Gly Arg Asp 
    1565                 1570                 1575             


Gly Val  Pro Gly Gly Pro Gly  Glu Thr Gly Lys Asn  Gly Gly Phe 
    1580                 1585                 1590             


Gly Arg  Arg Gly Pro Pro Gly  Ala Lys Gly Asn Lys  Gly Gly Pro 
    1595                 1600                 1605             


Gly Gln  Pro Gly Phe Glu Gly  Glu Gln Gly Thr Arg  Gly Ala Gln 
    1610                 1615                 1620             


Gly Pro  Ala Gly Pro Ala Gly  Pro Pro Gly Leu Ile  Gly Glu Gln 
    1625                 1630                 1635             


Gly Ile  Ser Gly Pro Arg Gly  Ser Gly Gly Ala Ala  Gly Ala Pro 
    1640                 1645                 1650             


Gly Glu  Arg Gly Arg Thr Gly  Pro Leu Gly Arg Lys  Gly Glu Pro 
    1655                 1660                 1665             


Gly Glu  Pro Gly Pro Lys Gly  Gly Ile Gly Asn Arg  Gly Pro Arg 
    1670                 1675                 1680             


Gly Glu  Thr Gly Asp Asp Gly  Arg Asp Gly Val Gly  Ser Glu Gly 
    1685                 1690                 1695             


Arg Arg  Gly Lys Lys Gly Glu  Arg Gly Phe Pro Gly  Tyr Pro Gly 
    1700                 1705                 1710             


Pro Lys  Gly Asn Pro Gly Glu  Pro Gly Leu Asn Gly  Thr Thr Gly 
    1715                 1720                 1725             


Pro Lys  Gly Ile Arg Gly Arg  Arg Gly Asn Ser Gly  Pro Pro Gly 
    1730                 1735                 1740             


Ile Val  Gly Gln Lys Gly Asp  Pro Gly Tyr Pro Gly  Pro Ala Gly 
    1745                 1750                 1755             


Pro Lys  Gly Asn Arg Gly Asp  Ser Ile Asp Gln Cys  Ala Leu Ile 
    1760                 1765                 1770             


Gln Ser  Ile Lys Asp Lys Cys  Pro Phe His Gly Pro  Leu Glu Cys 
    1775                 1780                 1785             


Pro Val  Phe Pro Thr Glu Leu  Ala Phe Ala Leu Asp  Thr Ser Glu 
    1790                 1795                 1800             


Gly Val  Asn Gln Asp Thr Phe  Gly Arg Met Arg Asp  Val Val Leu 
    1805                 1810                 1815             


Ser Ile  Val Asn Asp Leu Thr  Ile Ala Glu Ser Asn  Cys Pro Arg 
    1820                 1825                 1830             


Gly Ala  Arg Val Ala Val Val  Thr Tyr Asn Asn Glu  Val Thr Thr 
    1835                 1840                 1845             


Glu Ile  Arg Phe Ala Asp Ser  Lys Arg Lys Ser Val  Leu Leu Asp 
    1850                 1855                 1860             


Lys Ile  Lys Asn Leu Gln Val  Ala Leu Thr Ser Lys  Gln Gln Ser 
    1865                 1870                 1875             


Leu Glu  Thr Ala Met Ser Phe  Val Ala Arg Asn Thr  Phe Lys Arg 
    1880                 1885                 1890             


Val Arg  Asn Gly Phe Leu Met  Arg Lys Val Ala Val  Phe Phe Ser 
    1895                 1900                 1905             


Asn Thr  Pro Thr Arg Ala Ser  Pro Gln Leu Arg Glu  Ala Val Leu 
    1910                 1915                 1920             


Lys Leu  Ser Asp Ala Gly Ile  Thr Pro Leu Phe Leu  Thr Arg Gln 
    1925                 1930                 1935             


Glu Asp  Arg Gln Leu Ile Asn  Ala Leu Gln Ile Asn  Asn Thr Ala 
    1940                 1945                 1950             


Val Gly  His Ala Leu Val Leu  Pro Ala Gly Arg Asp  Leu Thr Asp 
    1955                 1960                 1965             


Phe Leu  Glu Asn Val Leu Thr  Cys His Val Cys Leu  Asp Ile Cys 
    1970                 1975                 1980             


Asn Ile  Asp Pro Ser Cys Gly  Phe Gly Ser Trp Arg  Pro Ser Phe 
    1985                 1990                 1995             


Arg Asp  Arg Arg Ala Ala Gly  Ser Asp Val Asp Ile  Asp Met Ala 
    2000                 2005                 2010             


Phe Ile  Leu Asp Ser Ala Glu  Thr Thr Thr Leu Phe  Gln Phe Asn 
    2015                 2020                 2025             


Glu Met  Lys Lys Tyr Ile Ala  Tyr Leu Val Arg Gln  Leu Asp Met 
    2030                 2035                 2040             


Ser Pro  Asp Pro Lys Ala Ser  Gln His Phe Ala Arg  Val Ala Val 
    2045                 2050                 2055             


Val Gln  His Ala Pro Ser Glu  Ser Val Asp Asn Ala  Ser Met Pro 
    2060                 2065                 2070             


Pro Val  Lys Val Glu Phe Ser  Leu Thr Asp Tyr Gly  Ser Lys Glu 
    2075                 2080                 2085             


Lys Leu  Val Asp Phe Leu Ser  Arg Gly Met Thr Gln  Leu Gln Gly 
    2090                 2095                 2100             


Thr Arg  Ala Leu Gly Ser Ala  Ile Glu Tyr Thr Ile  Glu Asn Val 
    2105                 2110                 2115             


Phe Glu  Ser Ala Pro Asn Pro  Arg Asp Leu Lys Ile  Val Val Leu 
    2120                 2125                 2130             


Met Leu  Thr Gly Glu Val Pro  Glu Gln Gln Leu Glu  Glu Ala Gln 
    2135                 2140                 2145             


Arg Val  Ile Leu Gln Ala Lys  Cys Lys Gly Tyr Phe  Phe Val Val 
    2150                 2155                 2160             


Leu Gly  Ile Gly Arg Lys Val  Asn Ile Lys Glu Val  Tyr Thr Phe 
    2165                 2170                 2175             


Ala Ser  Glu Pro Asn Asp Val  Phe Phe Lys Leu Val  Asp Lys Ser 
    2180                 2185                 2190             


Thr Glu  Leu Asn Glu Glu Pro  Leu Met Arg Phe Gly  Arg Leu Leu 
    2195                 2200                 2205             


Pro Ser  Phe Val Ser Ser Glu  Asn Ala Phe Tyr Leu  Ser Pro Asp 
    2210                 2215                 2220             


Ile Arg  Lys Gln Cys Asp Trp  Phe Gln Gly Asp Gln  Pro Thr Lys 
    2225                 2230                 2235             


Asn Leu  Val Lys Phe Gly His  Lys Gln Val Asn Val  Pro Asn Asn 
    2240                 2245                 2250             


Val Thr  Ser Ser Pro Thr Ser  Asn Pro Val Thr Thr  Thr Lys Pro 
    2255                 2260                 2265             


Val Thr  Thr Thr Lys Pro Val  Thr Thr Thr Thr Lys  Pro Val Thr 
    2270                 2275                 2280             


Thr Thr  Thr Lys Pro Val Thr  Ile Ile Asn Gln Pro  Ser Val Lys 
    2285                 2290                 2295             


Pro Ala  Ala Ala Lys Pro Ala  Pro Ala Lys Pro Val  Ala Ala Lys 
    2300                 2305                 2310             


Pro Val  Ala Thr Lys Met Ala  Thr Val Arg Pro Pro  Val Ala Val 
    2315                 2320                 2325             


Lys Pro  Ala Thr Ala Ala Lys  Pro Val Ala Ala Lys  Pro Ala Ala 
    2330                 2335                 2340             


Val Arg  Pro Pro Ala Ala Ala  Ala Ala Lys Pro Val  Ala Thr Lys 
    2345                 2350                 2355             


Pro Glu  Val Pro Arg Pro Gln  Ala Ala Lys Pro Ala  Ala Thr Lys 
    2360                 2365                 2370             


Pro Ala  Thr Thr Lys Pro Met  Val Lys Met Ser Arg  Glu Val Gln 
    2375                 2380                 2385             


Val Phe  Glu Ile Thr Glu Asn  Ser Ala Lys Leu His  Trp Glu Arg 
    2390                 2395                 2400             


Ala Glu  Pro Pro Gly Pro Tyr  Phe Tyr Asp Leu Thr  Val Thr Ser 
    2405                 2410                 2415             


Ala His  Asp Gln Ser Leu Val  Leu Lys Gln Asn Leu  Thr Val Thr 
    2420                 2425                 2430             


Asp Arg  Val Ile Gly Gly Leu  Leu Ala Gly Gln Thr  Tyr His Val 
    2435                 2440                 2445             


Ala Val  Val Cys Tyr Leu Arg  Ser Gln Val Arg Ala  Thr Tyr His 
    2450                 2455                 2460             


Gly Ser  Phe Ser Thr Lys Lys  Ser Gln Pro Pro Pro  Pro Gln Pro 
    2465                 2470                 2475             


Ala Arg  Ser Ala Ser Ser Ser  Thr Ile Asn Leu Met  Val Ser Thr 
    2480                 2485                 2490             


Glu Pro  Leu Ala Leu Thr Glu  Thr Asp Ile Cys Lys  Leu Pro Lys 
    2495                 2500                 2505             


Asp Glu  Gly Thr Cys Arg Asp  Phe Ile Leu Lys Trp  Tyr Tyr Asp 
    2510                 2515                 2520             


Pro Asn  Thr Lys Ser Cys Ala  Arg Phe Trp Tyr Gly  Gly Cys Gly 
    2525                 2530                 2535             


Gly Asn  Glu Asn Lys Phe Gly  Ser Gln Lys Glu Cys  Glu Lys Val 
    2540                 2545                 2550             


Cys Ala  Pro Val Leu Ala Lys  Pro Gly Val Ile Ser  Val Met Gly 
    2555                 2560                 2565             


Thr 
    


<210>  120
<211>  708
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Collagen type VI, alpha 3 Variant 8

<400>  120

Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe 
1               5                   10                  15      


Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Asp Val 
            20                  25                  30          


Lys Asn Gly Ala Ala Ala Asp Ile Ile Phe Leu Val Asp Ser Ser Trp 
        35                  40                  45              


Thr Ile Gly Glu Glu His Phe Gln Leu Val Arg Glu Phe Leu Tyr Asp 
    50                  55                  60                  


Val Val Lys Ser Leu Ala Val Gly Glu Asn Asp Phe His Phe Ala Leu 
65                  70                  75                  80  


Val Gln Phe Asn Gly Asn Pro His Thr Glu Phe Leu Leu Asn Thr Tyr 
                85                  90                  95      


Arg Thr Lys Gln Glu Val Leu Ser His Ile Ser Asn Met Ser Tyr Ile 
            100                 105                 110         


Gly Gly Thr Asn Gln Thr Gly Lys Gly Leu Glu Tyr Ile Met Gln Ser 
        115                 120                 125             


His Leu Thr Lys Ala Ala Gly Ser Arg Ala Gly Asp Gly Val Pro Gln 
    130                 135                 140                 


Val Ile Val Val Leu Thr Asp Gly His Ser Lys Asp Gly Leu Ala Leu 
145                 150                 155                 160 


Pro Ser Ala Glu Leu Lys Ser Ala Asp Val Asn Val Phe Ala Ile Gly 
                165                 170                 175     


Val Glu Asp Ala Asp Glu Gly Ala Leu Lys Glu Ile Ala Ser Glu Pro 
            180                 185                 190         


Leu Asn Met His Met Phe Asn Leu Glu Asn Phe Thr Ser Leu His Asp 
        195                 200                 205             


Ile Val Gly Asn Leu Val Ser Cys Val His Ser Ser Val Ser Pro Glu 
    210                 215                 220                 


Arg Ala Gly Asp Thr Glu Thr Leu Lys Asp Ile Thr Ala Gln Asp Ser 
225                 230                 235                 240 


Ala Asp Ile Ile Phe Leu Ile Asp Gly Ser Asn Asn Thr Gly Ser Val 
                245                 250                 255     


Asn Phe Ala Val Ile Leu Asp Phe Leu Val Asn Leu Leu Glu Lys Leu 
            260                 265                 270         


Pro Ile Gly Thr Gln Gln Ile Arg Val Gly Val Val Gln Phe Ser Asp 
        275                 280                 285             


Glu Pro Arg Thr Met Phe Ser Leu Asp Thr Tyr Ser Thr Lys Ala Gln 
    290                 295                 300                 


Val Leu Gly Ala Val Lys Ala Leu Gly Phe Ala Gly Gly Glu Leu Ala 
305                 310                 315                 320 


Asn Ile Gly Leu Ala Leu Asp Phe Val Val Glu Asn His Phe Thr Arg 
                325                 330                 335     


Ala Gly Gly Ser Arg Val Glu Glu Gly Val Pro Gln Val Leu Val Leu 
            340                 345                 350         


Ile Ser Ala Gly Pro Ser Ser Asp Glu Ile Arg Tyr Gly Val Val Ala 
        355                 360                 365             


Leu Lys Gln Ala Ser Val Phe Ser Phe Gly Leu Gly Ala Gln Ala Ala 
    370                 375                 380                 


Ser Arg Ala Glu Leu Gln His Ile Ala Thr Asp Asp Asn Leu Val Phe 
385                 390                 395                 400 


Thr Val Pro Glu Phe Arg Ser Phe Gly Asp Leu Gln Glu Lys Leu Leu 
                405                 410                 415     


Pro Tyr Ile Val Gly Val Ala Gln Arg His Ile Val Leu Lys Pro Pro 
            420                 425                 430         


Thr Ile Val Thr Gln Val Ile Glu Val Asn Lys Arg Asp Ile Val Phe 
        435                 440                 445             


Leu Val Asp Gly Ser Ser Ala Leu Gly Leu Ala Asn Phe Asn Ala Ile 
    450                 455                 460                 


Arg Asp Phe Ile Ala Lys Val Ile Gln Arg Leu Glu Ile Gly Gln Asp 
465                 470                 475                 480 


Leu Ile Gln Val Ala Val Ala Gln Tyr Ala Asp Thr Val Arg Pro Glu 
                485                 490                 495     


Phe Tyr Phe Asn Thr His Pro Thr Lys Arg Glu Val Ile Thr Ala Val 
            500                 505                 510         


Arg Lys Met Lys Pro Leu Asp Gly Ser Ala Leu Tyr Thr Gly Ser Ala 
        515                 520                 525             


Leu Asp Phe Val Arg Asn Asn Leu Phe Thr Ser Ser Ala Gly Tyr Arg 
    530                 535                 540                 


Ala Ala Glu Gly Ile Pro Lys Leu Leu Val Leu Ile Thr Gly Gly Lys 
545                 550                 555                 560 


Ser Leu Asp Glu Ile Ser Gln Pro Ala Gln Glu Leu Lys Arg Ser Ser 
                565                 570                 575     


Ile Met Ala Phe Ala Ile Gly Asn Lys Gly Ala Asp Gln Ala Glu Leu 
            580                 585                 590         


Glu Glu Ile Ala Phe Asp Ser Ser Leu Val Phe Ile Pro Ala Glu Phe 
        595                 600                 605             


Arg Ala Ala Pro Leu Gln Gly Met Leu Pro Gly Leu Leu Ala Pro Leu 
    610                 615                 620                 


Arg Thr Leu Ser Gly Thr Pro Glu Glu Ser Lys Arg Asp Ile Leu Phe 
625                 630                 635                 640 


Leu Phe Asp Gly Ser Ala Asn Leu Val Gly Gln Phe Pro Val Val Arg 
                645                 650                 655     


Asp Phe Leu Tyr Lys Ile Ile Asp Glu Leu Asn Val Lys Pro Glu Gly 
            660                 665                 670         


Thr Arg Ile Ala Val Ala Gln Tyr Ser Asp Asp Val Lys Val Glu Ser 
        675                 680                 685             


Arg Phe Asp Glu His Gln Ser Lys Pro Glu Ile Leu Asn Leu Val Lys 
    690                 695                 700                 


Arg Met Lys Ile 
705             


<210>  121
<211>  173
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Collagen type VI, alpha 3 Variant 9

<400>  121

Pro Ile Gly Thr Gln Gln Ile Arg Val Gly Val Val Gln Phe Ser Asp 
1               5                   10                  15      


Glu Pro Arg Thr Met Phe Ser Leu Asp Thr Tyr Ser Thr Lys Ala Gln 
            20                  25                  30          


Val Leu Gly Ala Val Lys Ala Leu Gly Phe Ala Gly Gly Glu Leu Ala 
        35                  40                  45              


Asn Ile Gly Leu Ala Leu Asp Phe Val Val Glu Asn His Phe Thr Arg 
    50                  55                  60                  


Ala Gly Gly Ser Arg Val Glu Glu Gly Val Pro Gln Val Leu Val Leu 
65                  70                  75                  80  


Ile Ser Ala Gly Pro Ser Ser Asp Glu Ile Arg Tyr Gly Val Val Ala 
                85                  90                  95      


Leu Lys Gln Ala Ser Val Phe Ser Phe Gly Leu Gly Ala Gln Ala Ala 
            100                 105                 110         


Ser Arg Ala Glu Leu Gln His Ile Ala Thr Asp Asp Asn Leu Val Phe 
        115                 120                 125             


Thr Val Pro Glu Phe Arg Ser Phe Gly Asp Leu Gln Glu Lys Leu Leu 
    130                 135                 140                 


Pro Tyr Ile Val Gly Val Ala Gln Arg His Ile Val Leu Lys Pro Pro 
145                 150                 155                 160 


Thr Ile Val Thr Gln Glu Tyr Gly Leu Asn Glu Asn Trp 
                165                 170             


<210>  122
<211>  203
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Proteasome subunit beta type-5 Variant 2

<400>  122

Met Ala Leu Ala Ser Val Leu Glu Arg Pro Leu Pro Val Asn Gln Arg 
1               5                   10                  15      


Gly Phe Phe Gly Leu Gly Gly Arg Ala Asp Leu Leu Asp Leu Gly Pro 
            20                  25                  30          


Gly Ser Leu Ser Asp Gly Leu Ser Leu Ala Ala Pro Gly Trp Gly Val 
        35                  40                  45              


Pro Glu Glu Pro Gly Ile Glu Met Leu His Gly Thr Thr Thr Leu Ala 
    50                  55                  60                  


Phe Lys Phe Arg His Gly Val Ile Val Ala Ala Asp Ser Arg Ala Thr 
65                  70                  75                  80  


Ala Gly Ala Tyr Ile Ala Ser Gln Thr Val Lys Lys Val Ile Glu Ile 
                85                  90                  95      


Asn Pro Tyr Leu Leu Gly Thr Met Ala Gly Gly Ala Ala Asp Cys Ser 
            100                 105                 110         


Phe Trp Glu Arg Leu Leu Ala Arg Gln Cys Arg Ile Tyr Glu Leu Arg 
        115                 120                 125             


Asn Lys Glu Arg Ile Ser Val Ala Ala Ala Ser Lys Leu Leu Ala Asn 
    130                 135                 140                 


Met Val Tyr Gln Tyr Lys Gly Met Gly Leu Ser Met Gly Thr Met Ile 
145                 150                 155                 160 


Cys Gly Trp Asp Lys Arg Gly Pro Val Ser Glu Val Leu Cys Leu Lys 
                165                 170                 175     


Pro Lys Ser Phe Gly Met Tyr Leu Phe Cys Gly Cys Ala Glu Arg Ile 
            180                 185                 190         


Gly Asn Met Ala Arg Pro Leu Leu Arg Gly Gln 
        195                 200             


<210>  123
<211>  160
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Proteasome subunit beta type-5 Variant 3

<400>  123

Met Ala Gly Gly Ala Ala Asp Cys Ser Phe Trp Glu Arg Leu Leu Ala 
1               5                   10                  15      


Arg Gln Cys Arg Ile Tyr Glu Leu Arg Asn Lys Glu Arg Ile Ser Val 
            20                  25                  30          


Ala Ala Ala Ser Lys Leu Leu Ala Asn Met Val Tyr Gln Tyr Lys Gly 
        35                  40                  45              


Met Gly Leu Ser Met Gly Thr Met Ile Cys Gly Trp Asp Lys Arg Gly 
    50                  55                  60                  


Pro Gly Leu Tyr Tyr Val Asp Ser Glu Gly Asn Arg Ile Ser Gly Ala 
65                  70                  75                  80  


Thr Phe Ser Val Gly Ser Gly Ser Val Tyr Ala Tyr Gly Val Met Asp 
                85                  90                  95      


Arg Gly Tyr Ser Tyr Asp Leu Glu Val Glu Gln Ala Tyr Asp Leu Ala 
            100                 105                 110         


Arg Arg Ala Ile Tyr Gln Ala Thr Tyr Arg Asp Ala Tyr Ser Gly Gly 
        115                 120                 125             


Ala Val Asn Leu Tyr His Val Arg Glu Asp Gly Trp Ile Arg Val Ser 
    130                 135                 140                 


Ser Asp Asn Val Ala Asp Leu His Glu Lys Tyr Ser Gly Ser Thr Pro 
145                 150                 155                 160 


<210>  124
<211>  84
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Proteasome subunit beta type-5 Variant 4

<400>  124

Met Ala Leu Ala Ser Val Leu Glu Arg Pro Leu Pro Val Asn Gln Arg 
1               5                   10                  15      


Gly Phe Phe Gly Leu Gly Gly Arg Ala Asp Leu Leu Asp Leu Gly Pro 
            20                  25                  30          


Gly Ser Leu Ser Asp Gly Leu Ser Leu Ala Ala Pro Gly Trp Gly Val 
        35                  40                  45              


Pro Glu Glu Pro Gly Ile Glu Met Leu His Gly Thr Thr Thr Leu Ala 
    50                  55                  60                  


Phe Lys Ala Ser Thr Thr Trp Thr Val Lys Gly Thr Gly Phe Gln Gly 
65                  70                  75                  80  


Pro Pro Ser Leu 
                


<210>  125
<211>  118
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Proteasome subunit beta type-5 Variant 5

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  125

Xaa Gly Ile Glu Met Leu His Gly Thr Thr Thr Leu Ala Phe Lys Phe 
1               5                   10                  15      


Arg His Gly Val Ile Val Ala Ala Asp Ser Arg Ala Thr Ala Gly Ala 
            20                  25                  30          


Tyr Ile Ala Ser Gln Thr Val Lys Lys Val Ile Glu Ile Asn Pro Tyr 
        35                  40                  45              


Leu Leu Gly Thr Met Ala Gly Gly Ala Ala Asp Cys Ser Phe Trp Glu 
    50                  55                  60                  


Arg Leu Leu Ala Arg Gln Cys Arg Ile Tyr Glu Leu Arg Asn Lys Glu 
65                  70                  75                  80  


Arg Ile Ser Val Ala Ala Ala Ser Lys Leu Leu Ala Asn Met Val Tyr 
                85                  90                  95      


Gln Tyr Lys Gly Met Gly Leu Ser Met Gly Thr Met Ile Cys Gly Trp 
            100                 105                 110         


Asp Lys Arg Gly Pro Gly 
        115             


<210>  126
<211>  341
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heterogeneous nuclear ribonucleoproteins A2/B1 Variant 2

<400>  126

Met Glu Arg Glu Lys Glu Gln Phe Arg Lys Leu Phe Ile Gly Gly Leu 
1               5                   10                  15      


Ser Phe Glu Thr Thr Glu Glu Ser Leu Arg Asn Tyr Tyr Glu Gln Trp 
            20                  25                  30          


Gly Lys Leu Thr Asp Cys Val Val Met Arg Asp Pro Ala Ser Lys Arg 
        35                  40                  45              


Ser Arg Gly Phe Gly Phe Val Thr Phe Ser Ser Met Ala Glu Val Asp 
    50                  55                  60                  


Ala Ala Met Ala Ala Arg Pro His Ser Ile Asp Gly Arg Val Val Glu 
65                  70                  75                  80  


Pro Lys Arg Ala Val Ala Arg Glu Glu Ser Gly Lys Pro Gly Ala His 
                85                  90                  95      


Val Thr Val Lys Lys Leu Phe Val Gly Gly Ile Lys Glu Asp Thr Glu 
            100                 105                 110         


Glu His His Leu Arg Asp Tyr Phe Glu Glu Tyr Gly Lys Ile Asp Thr 
        115                 120                 125             


Ile Glu Ile Ile Thr Asp Arg Gln Ser Gly Lys Lys Arg Gly Phe Gly 
    130                 135                 140                 


Phe Val Thr Phe Asp Asp His Asp Pro Val Asp Lys Ile Val Leu Gln 
145                 150                 155                 160 


Lys Tyr His Thr Ile Asn Gly His Asn Ala Glu Val Arg Lys Ala Leu 
                165                 170                 175     


Ser Arg Gln Glu Met Gln Glu Val Gln Ser Ser Arg Ser Gly Arg Gly 
            180                 185                 190         


Gly Asn Phe Gly Phe Gly Asp Ser Arg Gly Gly Gly Gly Asn Phe Gly 
        195                 200                 205             


Pro Gly Pro Gly Ser Asn Phe Arg Gly Gly Ser Asp Gly Tyr Gly Ser 
    210                 215                 220                 


Gly Arg Gly Phe Gly Asp Gly Tyr Asn Gly Tyr Gly Gly Gly Pro Gly 
225                 230                 235                 240 


Gly Gly Asn Phe Gly Gly Ser Pro Gly Tyr Gly Gly Gly Arg Gly Gly 
                245                 250                 255     


Tyr Gly Gly Gly Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly 
            260                 265                 270         


Gly Gly Tyr Asp Asn Tyr Gly Gly Gly Asn Tyr Gly Ser Gly Asn Tyr 
        275                 280                 285             


Asn Asp Phe Gly Asn Tyr Asn Gln Gln Pro Ser Asn Tyr Gly Pro Met 
    290                 295                 300                 


Lys Ser Gly Asn Phe Gly Gly Ser Arg Asn Met Gly Gly Pro Tyr Gly 
305                 310                 315                 320 


Gly Gly Asn Tyr Gly Pro Gly Gly Ser Gly Gly Ser Gly Gly Tyr Gly 
                325                 330                 335     


Gly Arg Ser Arg Tyr 
            340     


<210>  127
<211>  341
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heterogeneous nuclear ribonucleoproteins A2/B1 Variant 3

<400>  127

Met Glu Arg Glu Lys Glu Gln Phe Arg Lys Leu Phe Ile Gly Gly Leu 
1               5                   10                  15      


Ser Phe Glu Thr Thr Glu Glu Ser Leu Arg Asn Tyr Tyr Glu Gln Trp 
            20                  25                  30          


Gly Lys Leu Thr Asp Cys Val Val Met Arg Asp Pro Ala Ser Lys Arg 
        35                  40                  45              


Ser Arg Gly Phe Gly Phe Val Thr Phe Ser Ser Met Ala Glu Val Asp 
    50                  55                  60                  


Ala Ala Met Ala Ala Arg Pro His Ser Ile Asp Gly Arg Val Val Glu 
65                  70                  75                  80  


Pro Lys Arg Ala Val Ala Arg Glu Glu Ser Gly Lys Pro Gly Ala His 
                85                  90                  95      


Val Thr Val Lys Lys Leu Phe Val Gly Gly Ile Lys Glu Asp Thr Glu 
            100                 105                 110         


Glu His His Leu Arg Asp Tyr Phe Glu Glu Tyr Gly Lys Ile Asp Thr 
        115                 120                 125             


Ile Glu Ile Ile Thr Asp Arg Gln Ser Gly Lys Lys Arg Gly Phe Gly 
    130                 135                 140                 


Phe Val Thr Phe Asp Asp His Asp Pro Val Asp Lys Ile Val Leu Gln 
145                 150                 155                 160 


Lys Tyr His Thr Ile Asn Gly His Asn Ala Glu Val Arg Lys Ala Leu 
                165                 170                 175     


Ser Arg Gln Glu Met Gln Glu Val Gln Ser Ser Arg Ser Gly Arg Gly 
            180                 185                 190         


Gly Asn Phe Gly Phe Gly Asp Ser Arg Gly Gly Gly Gly Asn Phe Gly 
        195                 200                 205             


Pro Gly Pro Gly Ser Asn Phe Arg Gly Gly Ser Asp Gly Tyr Gly Ser 
    210                 215                 220                 


Gly Arg Gly Phe Gly Asp Gly Tyr Asn Gly Tyr Gly Gly Gly Pro Gly 
225                 230                 235                 240 


Gly Gly Asn Phe Gly Gly Ser Pro Gly Tyr Gly Gly Gly Arg Gly Gly 
                245                 250                 255     


Tyr Gly Gly Gly Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly 
            260                 265                 270         


Gly Gly Tyr Asp Asn Tyr Gly Gly Gly Asn Tyr Gly Ser Gly Asn Tyr 
        275                 280                 285             


Asn Asp Phe Gly Asn Tyr Asn Gln Gln Pro Ser Asn Tyr Gly Pro Met 
    290                 295                 300                 


Lys Ser Gly Asn Phe Gly Gly Ser Arg Asn Met Gly Gly Pro Tyr Gly 
305                 310                 315                 320 


Gly Gly Asn Tyr Gly Pro Gly Gly Ser Gly Gly Ser Gly Gly Tyr Gly 
                325                 330                 335     


Gly Arg Ser Arg Tyr 
            340     


<210>  128
<211>  261
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Heterogeneous nuclear ribonucleoproteins A2/B1 Variant 4

<400>  128

Met Glu Lys Thr Leu Glu Thr Val Pro Leu Glu Arg Lys Lys Arg Glu 
1               5                   10                  15      


Lys Glu Gln Phe Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr 
            20                  25                  30          


Thr Glu Glu Ser Leu Arg Asn Tyr Tyr Glu Gln Trp Gly Lys Leu Thr 
        35                  40                  45              


Asp Cys Val Val Met Arg Asp Pro Ala Ser Lys Arg Ser Arg Gly Phe 
    50                  55                  60                  


Gly Phe Val Thr Phe Ser Ser Met Ala Glu Val Asp Ala Ala Met Ala 
65                  70                  75                  80  


Ala Arg Pro His Ser Ile Asp Gly Arg Val Val Glu Pro Lys Arg Ala 
                85                  90                  95      


Val Ala Arg Glu Glu Ser Gly Lys Pro Gly Ala His Val Thr Val Lys 
            100                 105                 110         


Lys Leu Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu His His Leu 
        115                 120                 125             


Arg Asp Tyr Phe Glu Glu Tyr Gly Lys Ile Asp Thr Ile Glu Ile Ile 
    130                 135                 140                 


Thr Asp Arg Gln Ser Gly Lys Lys Arg Gly Phe Gly Phe Val Thr Phe 
145                 150                 155                 160 


Asp Asp His Asp Pro Val Asp Lys Ile Val Leu Gln Lys Tyr His Thr 
                165                 170                 175     


Ile Asn Gly His Asn Ala Glu Val Arg Lys Ala Leu Ser Arg Gln Glu 
            180                 185                 190         


Met Gln Glu Asp Leu Glu Val Ala Ile Leu Glu Val Ala Pro Val Met 
        195                 200                 205             


Glu Glu Glu Glu Glu Asp Met Val Val Glu Asp Leu Asp Met Ala Thr 
    210                 215                 220                 


Arg Val Gly Ala Thr Glu Val Val Met Thr Thr Met Glu Glu Glu Ile 
225                 230                 235                 240 


Met Glu Val Glu Ile Thr Met Ile Leu Glu Ile Ile Thr Ser Asn Leu 
                245                 250                 255     


Leu Thr Thr Val Gln 
            260     


<210>  129
<211>  434
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Beta enolaseVariant 2

<400>  129

Met Ala Met Gln Lys Ile Phe Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu His Thr Ala Lys Gly Arg Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gly Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Glu Asn Ile Asn Asn Thr Leu Gly Pro Ala Leu Leu Gln Lys 
65                  70                  75                  80  


Lys Leu Ser Val Val Asp Gln Glu Lys Val Asp Lys Phe Met Ile Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Pro Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ser 
                165                 170                 175     


Ser Phe Lys Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His His Leu 
            180                 185                 190         


Lys Gly Val Ile Lys Ala Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Asn Glu Ala Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gln Ala Ala Gly Tyr Pro Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Asn Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ala Arg His Ile Thr 
            260                 265                 270         


Gly Glu Lys Leu Gly Glu Leu Tyr Lys Ser Phe Ile Lys Asn Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Ala Thr Trp 
    290                 295                 300                 


Thr Ser Phe Leu Ser Gly Val Asn Ile Gln Ile Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Gln Ala Val Glu Lys Lys Ala 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Ile Gln Ala Cys Lys Leu Ala Gln Ser Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met Arg Ile Glu Glu Ala 
                405                 410                 415     


Leu Gly Asp Lys Ala Ile Phe Ala Gly Arg Lys Phe Arg Asn Pro Lys 
            420                 425                 430         


Ala Lys 
        


<210>  130
<211>  434
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Beta enolase Variant 3

<400>  130

Met Ala Met Gln Lys Ile Phe Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu His Thr Ala Lys Gly Arg Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gly Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Glu Asn Ile Asn Asn Thr Leu Gly Pro Ala Leu Leu Gln Lys 
65                  70                  75                  80  


Lys Leu Ser Val Val Asp Gln Glu Lys Val Asp Lys Phe Met Ile Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Pro Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ser 
                165                 170                 175     


Ser Phe Lys Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His His Leu 
            180                 185                 190         


Lys Gly Val Ile Lys Ala Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Asn Glu Ala Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gln Ala Ala Gly Tyr Pro Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Asn Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ala Arg His Ile Thr 
            260                 265                 270         


Gly Glu Lys Leu Gly Glu Leu Tyr Lys Ser Phe Ile Lys Asn Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Ala Thr Trp 
    290                 295                 300                 


Thr Ser Phe Leu Ser Gly Val Asn Ile Gln Ile Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Gln Ala Val Glu Lys Lys Ala 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Ile Gln Ala Cys Lys Leu Ala Gln Ser Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met Arg Ile Glu Glu Ala 
                405                 410                 415     


Leu Gly Asp Lys Ala Ile Phe Ala Gly Arg Lys Phe Arg Asn Pro Lys 
            420                 425                 430         


Ala Lys 
        


<210>  131
<211>  391
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Beta enolase Variant 3

<400>  131

Met Ala Met Gln Lys Ile Phe Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu His Thr Ala Lys Gly Arg Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gly Arg Tyr Leu Gly Lys Ala Lys Phe Gly 
    50                  55                  60                  


Ala Asn Ala Ile Leu Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala 
65                  70                  75                  80  


Ala Glu Lys Gly Val Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly 
                85                  90                  95      


Asn Pro Asp Leu Ile Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly 
            100                 105                 110         


Gly Ser His Ala Gly Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu 
        115                 120                 125             


Pro Val Gly Ala Ser Ser Phe Lys Glu Ala Met Arg Ile Gly Ala Glu 
    130                 135                 140                 


Val Tyr His His Leu Lys Gly Val Ile Lys Ala Lys Tyr Gly Lys Asp 
145                 150                 155                 160 


Ala Thr Asn Val Gly Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu 
                165                 170                 175     


Asn Asn Glu Ala Leu Glu Leu Leu Lys Thr Ala Ile Gln Ala Ala Gly 
            180                 185                 190         


Tyr Pro Asp Lys Val Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe 
        195                 200                 205             


Tyr Arg Asn Gly Lys Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro 
    210                 215                 220                 


Ala Arg His Ile Thr Gly Glu Lys Leu Gly Glu Leu Tyr Lys Ser Phe 
225                 230                 235                 240 


Ile Lys Asn Tyr Pro Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp 
                245                 250                 255     


Asp Trp Ala Thr Trp Thr Ser Phe Leu Ser Gly Val Asn Ile Gln Ile 
            260                 265                 270         


Val Gly Asp Asp Leu Thr Val Thr Asn Pro Lys Arg Ile Ala Gln Ala 
        275                 280                 285             


Val Glu Lys Lys Ala Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile 
    290                 295                 300                 


Gly Ser Val Thr Glu Ser Ile Gln Ala Cys Lys Leu Ala Gln Ser Asn 
305                 310                 315                 320 


Gly Trp Gly Val Met Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr 
                325                 330                 335     


Phe Ile Ala Asp Leu Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr 
            340                 345                 350         


Gly Ala Pro Cys Arg Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met 
        355                 360                 365             


Arg Ile Glu Glu Ala Leu Gly Asp Lys Ala Ile Phe Ala Gly Arg Lys 
    370                 375                 380                 


Phe Arg Asn Pro Lys Ala Lys 
385                 390     


<210>  132
<211>  212
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Beta enolase Variant 5

<400>  132

Met Ala Met Gln Lys Ile Phe Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu His Thr Ala Lys Gly Arg Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gly Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Glu Asn Ile Asn Asn Thr Leu Gly Pro Ala Leu Leu Gln Lys 
65                  70                  75                  80  


Lys Leu Ser Val Val Asp Gln Glu Lys Val Asp Lys Phe Met Ile Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Pro Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ser 
                165                 170                 175     


Ser Phe Lys Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His His Leu 
            180                 185                 190         


Lys Gly Val Ile Lys Ala Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly 
    210         


<210>  133
<211>  196
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Beta enolase Variant 6

<400>  133

Met Ala Met Gln Lys Ile Phe Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu His Thr Ala Lys Gly Arg Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gly Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Glu Asn Ile Asn Asn Thr Leu Gly Pro Ala Leu Leu Gln Lys 
65                  70                  75                  80  


Lys Leu Ser Val Val Asp Gln Glu Lys Val Asp Lys Phe Met Ile Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Pro Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ser 
                165                 170                 175     


Ser Phe Lys Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His His Leu 
            180                 185                 190         


Lys Gly Val Ile 
        195     


<210>  134
<211>  148
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Beta enolase Variant 7

<400>  134

Met Ala Met Gln Lys Ile Phe Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu His Thr Ala Lys Gly Arg Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gly Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Glu Asn Ile Asn Asn Thr Leu Gly Pro Ala Leu Leu Gln Lys 
65                  70                  75                  80  


Lys Leu Ser Val Val Asp Gln Glu Lys Val Asp Lys Phe Met Ile Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Pro Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro 
145             


<210>  135
<211>  148
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Beta enolase Variant 8

<400>  135

Met Ala Met Gln Lys Ile Phe Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu His Thr Ala Lys Gly Arg Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gly Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Glu Asn Ile Asn Asn Thr Leu Gly Pro Ala Leu Leu Gln Lys 
65                  70                  75                  80  


Lys Leu Ser Val Val Asp Gln Glu Lys Val Asp Lys Phe Met Ile Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Pro Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro 
145             


<210>  136
<211>  154
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Beta enolase Variant 9

<400>  136

Met Ala Met Gln Lys Ile Phe Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu His Thr Ala Lys Gly Arg Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gly Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Glu Asn Ile Asn Asn Thr Leu Gly Pro Ala Leu Leu Gln Lys 
65                  70                  75                  80  


Lys Leu Ser Val Val Asp Gln Glu Lys Val Asp Lys Phe Met Ile Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Pro Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn 
145                 150                 


<210>  137
<211>  28
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Beta enolase Variant 10

<400>  137

Met Ala Met Gln Lys Ile Phe Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu His Thr Ala Lys 
            20                  25              


<210>  138
<211>  174
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Glutathione S-transferase P Variant 2

<400>  138

Met Pro Pro Tyr Thr Val Val Tyr Phe Pro Val Arg Gly Arg Cys Ala 
1               5                   10                  15      


Ala Leu Arg Met Leu Leu Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu 
            20                  25                  30          


Val Val Thr Val Glu Thr Trp Gln Glu Gly Ser Leu Lys Ala Ser Cys 
        35                  40                  45              


Leu Tyr Gly Gln Leu Pro Lys Phe Gln Asp Gly Asp Leu Thr Leu Tyr 
    50                  55                  60                  


Gln Ser Asn Thr Ile Leu Arg His Leu Gly Arg Thr Leu Gly Leu Tyr 
65                  70                  75                  80  


Gly Lys Asp Gln Gln Glu Ala Ala Leu Val Asp Met Val Asn Asp Gly 
                85                  90                  95      


Val Glu Asp Leu Arg Cys Lys Tyr Ile Ser Leu Ile Tyr Thr Asn Tyr 
            100                 105                 110         


Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu Leu Ile His Glu 
        115                 120                 125             


Val Leu Ala Pro Gly Cys Leu Asp Ala Phe Pro Leu Leu Ser Ala Tyr 
    130                 135                 140                 


Val Gly Arg Leu Ser Ala Arg Pro Lys Leu Lys Ala Phe Leu Ala Ser 
145                 150                 155                 160 


Pro Glu Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly Lys Gln 
                165                 170                 


<210>  139
<211>  69
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Glutathione S-transferase P Variant 3

<400>  139

Glu Ala Gly Lys Asp Asp Tyr Val Lys Ala Leu Pro Gly Gln Leu Lys 
1               5                   10                  15      


Pro Phe Glu Thr Leu Leu Ser Gln Asn Gln Gly Gly Lys Thr Phe Ile 
            20                  25                  30          


Val Gly Asp Gln Val Ser Ile Trp Pro His Ala Val Pro Ser Ser Pro 
        35                  40                  45              


Pro Ser Ala Ser Arg Trp Thr Gln Val Ser Pro Ser Leu Thr Thr Thr 
    50                  55                  60                  


Cys Trp Thr Cys Cys 
65                  


<210>  140
<211>  166
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Glutathione S-transferase Mu 3 Variant 2

<400>  140

Met Ser Cys Glu Ser Ser Met Val Leu Gly Tyr Trp Asp Ile Arg Gly 
1               5                   10                  15      


Leu Ala His Ala Ile Arg Leu Leu Leu Glu Phe Thr Asp Thr Ser Tyr 
            20                  25                  30          


Glu Glu Lys Arg Tyr Thr Cys Gly Glu Ala Pro Asp Tyr Asp Arg Ser 
        35                  40                  45              


Gln Trp Leu Asp Val Lys Phe Lys Leu Asp Leu Asp Phe Pro Asn Leu 
    50                  55                  60                  


Pro Tyr Leu Leu Asp Gly Lys Asn Lys Ile Thr Gln Ser Asn Ala Ile 
65                  70                  75                  80  


Leu Arg Tyr Ile Ala Arg Lys His Asn Met Cys Gly Glu Thr Glu Glu 
                85                  90                  95      


Glu Lys Ile Arg Val Asp Ile Ile Glu Asn Gln Val Met Asp Phe Arg 
            100                 105                 110         


Thr Gln Leu Ile Arg Leu Cys Tyr Ser Ser Asp His Glu Lys Leu Lys 
        115                 120                 125             


Pro Gln Tyr Leu Glu Glu Leu Pro Gly Gln Leu Lys Gln Phe Ser Met 
    130                 135                 140                 


Phe Leu Gly Lys Phe Ser Trp Phe Ala Gly Glu Lys Leu Thr Phe Val 
145                 150                 155                 160 


Asp Phe Leu Thr Tyr Asp 
                165     


<210>  141
<211>  212
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Glutathione S-transferase Mu 3 Variant 3

<400>  141

Met Ser Cys Glu Ser Ser Met Val Leu Gly Tyr Trp Asp Ile Arg Gly 
1               5                   10                  15      


Leu Ala His Ala Ile Arg Leu Leu Leu Glu Phe Thr Asp Thr Ser Tyr 
            20                  25                  30          


Glu Glu Lys Arg Tyr Thr Cys Gly Glu Ala Pro Asp Tyr Asp Arg Ser 
        35                  40                  45              


Gln Trp Leu Asp Val Lys Phe Lys Leu Asp Leu Asp Phe Pro Asn Leu 
    50                  55                  60                  


Pro Tyr Leu Leu Asp Gly Lys Asn Lys Ile Thr Gln Ser Asn Ala Ile 
65                  70                  75                  80  


Leu Arg Tyr Ile Ala Arg Lys His Asn Met Cys Gly Glu Thr Glu Glu 
                85                  90                  95      


Glu Lys Ile Arg Val Asp Ile Ile Glu Asn Gln Val Met Asp Phe Arg 
            100                 105                 110         


Thr Gln Leu Ile Arg Leu Cys Tyr Ser Ser Asp His Glu Lys Leu Lys 
        115                 120                 125             


Pro Gln Tyr Leu Glu Glu Leu Pro Gly Gln Leu Lys Gln Phe Ser Met 
    130                 135                 140                 


Phe Leu Gly Lys Phe Ser Trp Phe Ala Gly Glu Lys Leu Thr Phe Val 
145                 150                 155                 160 


Asp Phe Leu Thr Tyr Asp Ile Leu Asp Gln Asn Arg Ile Phe Asp Pro 
                165                 170                 175     


Lys Cys Leu Asp Glu Phe Pro Asn Leu Lys Ala Phe Met Cys Arg Phe 
            180                 185                 190         


Gly Asp Val Leu His Phe Leu Tyr Lys Thr Leu Thr Ala Pro Leu Gly 
        195                 200                 205             


Pro Ala Asp Pro 
    210         


<210>  142
<211>  1144
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  ARHGAP23 Variant 2

<400>  142

Met Asn Gly Val Ala Phe Cys Leu Val Gly Ile Pro Pro Arg Pro Glu 
1               5                   10                  15      


Pro Arg Pro Pro Gln Leu Pro Leu Gly Pro Arg Asp Gly Cys Ser Pro 
            20                  25                  30          


Arg Arg Pro Phe Pro Trp Gln Gly Pro Arg Thr Leu Leu Leu Tyr Lys 
        35                  40                  45              


Ser Pro Gln Asp Gly Phe Gly Phe Thr Leu Arg His Phe Ile Val Tyr 
    50                  55                  60                  


Pro Pro Glu Ser Ala Val His Cys Ser Leu Lys Glu Glu Glu Asn Gly 
65                  70                  75                  80  


Gly Arg Gly Gly Gly Pro Ser Pro Arg Tyr Arg Leu Glu Pro Met Asp 
                85                  90                  95      


Thr Ile Phe Val Lys Asn Val Lys Glu Asp Gly Pro Ala His Arg Ala 
            100                 105                 110         


Gly Leu Arg Thr Gly Asp Arg Leu Val Lys Val Asn Gly Glu Ser Val 
        115                 120                 125             


Ile Gly Lys Thr Tyr Ser Gln Val Ile Ala Leu Ile Gln Asn Ser Asp 
    130                 135                 140                 


Asp Thr Leu Glu Leu Ser Ile Met Pro Lys Asp Glu Asp Ile Leu Gln 
145                 150                 155                 160 


Leu Ala Tyr Ser Gln Asp Ala Tyr Leu Lys Gly Asn Glu Pro Tyr Ser 
                165                 170                 175     


Gly Glu Ala Arg Ser Ile Pro Glu Pro Pro Pro Ile Cys Tyr Pro Arg 
            180                 185                 190         


Lys Thr Tyr Ala Pro Pro Ala Arg Ala Ser Thr Arg Ala Thr Met Val 
        195                 200                 205             


Pro Glu Pro Thr Ser Ala Leu Pro Ser Asp Pro Arg Ser Pro Ala Ala 
    210                 215                 220                 


Trp Ser Asp Pro Gly Leu Arg Val Pro Pro Ala Ala Arg Ala His Leu 
225                 230                 235                 240 


Asp Asn Ser Ser Leu Gly Met Ser Gln Pro Arg Pro Ser Pro Gly Ala 
                245                 250                 255     


Phe Pro His Leu Ser Ser Glu Pro Arg Thr Pro Arg Ala Phe Pro Glu 
            260                 265                 270         


Pro Gly Ser Arg Val Pro Pro Ser Arg Leu Glu Cys Gln Gln Ala Leu 
        275                 280                 285             


Ser His Trp Leu Ser Asn Gln Val Pro Arg Arg Ala Gly Glu Arg Arg 
    290                 295                 300                 


Cys Pro Ala Met Ala Pro Arg Ala Arg Ser Ala Ser Gln Asp Arg Leu 
305                 310                 315                 320 


Glu Glu Val Ala Ala Pro Arg Pro Trp Pro Cys Ser Thr Ser Gln Asp 
                325                 330                 335     


Ala Leu Ser Gln Leu Gly Gln Glu Gly Trp His Arg Ala Arg Ser Asp 
            340                 345                 350         


Asp Tyr Leu Ser Arg Ala Thr Arg Ser Ala Glu Ala Leu Gly Pro Gly 
        355                 360                 365             


Ala Leu Val Ser Pro Arg Phe Glu Arg Cys Gly Trp Ala Ser Gln Arg 
    370                 375                 380                 


Ser Ser Ala Arg Thr Pro Ala Cys Pro Thr Arg Asp Leu Pro Gly Pro 
385                 390                 395                 400 


Gln Ala Pro Pro Pro Ser Gly Leu Gln Gly Leu Asp Asp Leu Gly Tyr 
                405                 410                 415     


Ile Gly Tyr Arg Ser Tyr Ser Pro Ser Phe Gln Arg Arg Thr Gly Leu 
            420                 425                 430         


Leu His Ala Leu Ser Phe Arg Asp Ser Pro Phe Gly Gly Leu Pro Thr 
        435                 440                 445             


Phe Asn Leu Ala Gln Ser Pro Ala Ser Phe Pro Pro Glu Ala Ser Glu 
    450                 455                 460                 


Pro Pro Arg Val Val Arg Pro Glu Pro Ser Thr Arg Ala Leu Glu Pro 
465                 470                 475                 480 


Pro Ala Glu Asp Arg Gly Asp Glu Val Val Leu Arg Gln Lys Pro Pro 
                485                 490                 495     


Thr Gly Arg Lys Val Gln Leu Thr Pro Ala Arg Gln Met Asn Leu Gly 
            500                 505                 510         


Phe Gly Asp Glu Ser Pro Glu Pro Glu Ala Ser Gly Arg Gly Glu Arg 
        515                 520                 525             


Leu Gly Arg Lys Val Ala Pro Leu Ala Thr Thr Glu Asp Ser Leu Ala 
    530                 535                 540                 


Ser Ile Pro Phe Ile Asp Glu Pro Thr Ser Pro Ser Ile Asp Leu Gln 
545                 550                 555                 560 


Ala Lys His Val Pro Ala Ser Ala Val Val Ser Ser Ala Met Asn Ser 
                565                 570                 575     


Ala Pro Val Leu Gly Thr Ser Pro Ser Ser Pro Thr Phe Thr Phe Thr 
            580                 585                 590         


Leu Gly Arg His Tyr Ser Gln Asp Cys Ser Ser Ile Lys Ala Gly Arg 
        595                 600                 605             


Arg Ser Ser Tyr Leu Leu Ala Ile Thr Thr Glu Arg Ser Lys Ser Cys 
    610                 615                 620                 


Asp Asp Gly Leu Asn Thr Phe Arg Asp Glu Gly Arg Val Leu Arg Arg 
625                 630                 635                 640 


Leu Pro Asn Arg Ile Pro Ser Leu Arg Met Leu Arg Ser Phe Phe Thr 
                645                 650                 655     


Asp Gly Ser Leu Asp Ser Trp Gly Thr Ser Glu Asp Ala Asp Ala Pro 
            660                 665                 670         


Ser Lys Arg His Ser Thr Ser Asp Leu Ser Asp Ala Thr Phe Ser Asp 
        675                 680                 685             


Ile Arg Arg Glu Gly Trp Leu Tyr Tyr Lys Gln Ile Leu Thr Lys Lys 
    690                 695                 700                 


Gly Lys Lys Ala Gly Ser Gly Leu Arg Gln Trp Lys Arg Val Tyr Ala 
705                 710                 715                 720 


Ala Leu Arg Ala Arg Ser Leu Ser Leu Ser Lys Glu Arg Arg Glu Pro 
                725                 730                 735     


Gly Pro Ala Ala Ala Gly Ala Ala Ala Ala Gly Ala Gly Glu Asp Glu 
            740                 745                 750         


Ala Ala Pro Val Cys Ile Gly Ser Cys Leu Val Asp Ile Ser Tyr Ser 
        755                 760                 765             


Glu Thr Lys Arg Arg His Val Phe Arg Leu Thr Thr Ala Asp Phe Cys 
    770                 775                 780                 


Glu Tyr Leu Phe Gln Ala Glu Asp Arg Asp Asp Met Leu Gly Trp Ile 
785                 790                 795                 800 


Arg Ala Ile Arg Glu Asn Ser Arg Ala Glu Gly Glu Asp Pro Gly Cys 
                805                 810                 815     


Ala Asn Gln Ala Leu Ile Ser Lys Lys Leu Asn Asp Tyr Arg Lys Val 
            820                 825                 830         


Ser His Ser Ser Gly Pro Lys Ala Asp Ser Ser Pro Lys Gly Ser Arg 
        835                 840                 845             


Gly Leu Gly Gly Leu Lys Ser Glu Phe Leu Lys Gln Ser Ala Ala Arg 
    850                 855                 860                 


Gly Leu Arg Thr Gln Asp Leu Pro Ala Gly Ser Lys Asp Asp Ser Ala 
865                 870                 875                 880 


Ala Ala Pro Lys Thr Pro Trp Gly Ile Asn Ile Ile Lys Lys Asn Lys 
                885                 890                 895     


Lys Ala Ala Pro Arg Ala Phe Gly Val Arg Leu Glu Glu Cys Gln Pro 
            900                 905                 910         


Ala Thr Glu Asn Gln Arg Val Pro Leu Ile Val Ala Ala Cys Cys Arg 
        915                 920                 925             


Ile Val Glu Ala Arg Gly Leu Glu Ser Thr Gly Ile Tyr Arg Val Pro 
    930                 935                 940                 


Gly Asn Asn Ala Val Val Ser Ser Leu Gln Glu Gln Leu Asn Arg Gly 
945                 950                 955                 960 


Pro Gly Asp Ile Asn Leu Gln Asp Glu Arg Trp Gln Asp Leu Asn Val 
                965                 970                 975     


Ile Ser Ser Leu Leu Lys Ser Phe Phe Arg Lys Leu Pro Glu Pro Leu 
            980                 985                 990         


Phe Thr Asp Asp Lys Tyr Asn Asp  Phe Ile Glu Ala Asn  Arg Ile Glu 
        995                 1000                 1005             


Asp Ala  Arg Glu Arg Met Arg  Thr Leu Arg Lys Leu  Ile Arg Asp 
    1010                 1015                 1020             


Leu Pro  Gly His Tyr Tyr Glu  Thr Leu Lys Phe Leu  Val Gly His 
    1025                 1030                 1035             


Leu Lys  Thr Ile Ala Asp His  Ser Glu Lys Asn Lys  Met Glu Pro 
    1040                 1045                 1050             


Arg Asn  Leu Ala Leu Val Phe  Gly Pro Thr Leu Val  Arg Thr Ser 
    1055                 1060                 1065             


Glu Asp  Asn Met Thr Asp Met  Val Thr His Met Pro  Asp Arg Tyr 
    1070                 1075                 1080             


Lys Ile  Val Glu Thr Leu Ile  Gln His Ser Asp Trp  Phe Phe Ser 
    1085                 1090                 1095             


Asp Glu  Glu Asp Lys Gly Glu  Arg Thr Pro Val Gly  Asp Lys Glu 
    1100                 1105                 1110             


Pro Gln  Ala Val Pro Asn Ile  Glu Tyr Leu Leu Pro  Asn Ile Gly 
    1115                 1120                 1125             


Arg Thr  Val Pro Pro Gly Asp  Pro Gly Ser Ala Asp  Leu Leu Glu 
    1130                 1135                 1140             


Ile 
    


<210>  143
<211>  102
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  ARHGAP23 Variant 3

<400>  143

Met Asp Thr Ile Phe Val Lys Asn Val Lys Glu Asp Gly Pro Ala His 
1               5                   10                  15      


Arg Ala Gly Leu Arg Thr Gly Asp Arg Leu Val Lys Val Asn Gly Glu 
            20                  25                  30          


Ser Val Ile Gly Lys Thr Tyr Ser Gln Val Ile Ala Leu Ile Gln Asn 
        35                  40                  45              


Ser Asp Asp Thr Leu Glu Leu Ser Ile Met Pro Lys Asp Glu Asp Ile 
    50                  55                  60                  


Leu Gln Leu Ala Tyr Ser Gln Asp Ala Tyr Leu Lys Gly Asn Glu Pro 
65                  70                  75                  80  


Tyr Ser Gly Glu Ala Arg Ser Ile Pro Glu Pro Pro Pro Ile Cys Tyr 
                85                  90                  95      


Pro Arg Lys Thr Tyr Ala 
            100         


<210>  144
<211>  64
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  ARHGAP23 Variant 4

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  144

Xaa Phe Phe Ser Asp Glu Glu Asp Lys Gly Glu Arg Thr Pro Val Gly 
1               5                   10                  15      


Asp Lys Glu Pro Gln Ala Val Pro Asn Ile Glu Tyr Leu Leu Pro Asn 
            20                  25                  30          


Ile Gly Arg Thr Val Pro Pro Gly Asp Pro Gly Ser Asp Ser Thr Thr 
        35                  40                  45              


Cys Ser Ser Ala Lys Ser Lys Val Arg Met Lys Ala Ile Leu Lys Ala 
    50                  55                  60                  


<210>  145
<211>  163
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  ARHGAP23 Variant 5

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  145

Xaa Thr Phe Ser Asp Ile Arg Arg Glu Gly Trp Leu Tyr Tyr Lys Gln 
1               5                   10                  15      


Ile Leu Thr Lys Lys Gly Lys Ala Glu Asp Arg Asp Asp Met Leu Gly 
            20                  25                  30          


Trp Ile Arg Ala Ile Arg Glu Asn Ser Arg Ala Glu Gly Glu Asp Pro 
        35                  40                  45              


Gly Cys Ala Asn Gln Ala Leu Ile Ser Lys Lys Leu Asn Asp Tyr Arg 
    50                  55                  60                  


Lys Val Ser His Ser Ser Gly Pro Lys Ala Asp Ser Ser Pro Lys Gly 
65                  70                  75                  80  


Ser Arg Gly Leu Gly Gly Leu Lys Ser Glu Phe Leu Lys Gln Ser Ala 
                85                  90                  95      


Ala Arg Gly Leu Arg Thr Gln Asp Leu Pro Ala Gly Ser Lys Asp Asp 
            100                 105                 110         


Ser Ala Ala Ala Pro Lys Thr Pro Trp Gly Ile Asn Ile Ile Lys Lys 
        115                 120                 125             


Asn Lys Lys Ala Ala Pro Arg Ala Phe Gly Val Arg Leu Glu Glu Cys 
    130                 135                 140                 


Gln Pro Ala Thr Glu Asn Gln Arg Val Pro Leu Ile Val Ala Ala Cys 
145                 150                 155                 160 


Cys Arg Ile 
            


<210>  146
<211>  135
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  ARHGAP23 Variant 6

<400>  146

Ile Arg Asp Leu Pro Gly His Tyr Tyr Glu Thr Leu Lys Phe Leu Val 
1               5                   10                  15      


Gly His Leu Lys Thr Ile Ala Asp His Ser Glu Lys Asn Lys Met Glu 
            20                  25                  30          


Pro Arg Asn Leu Ala Leu Val Phe Gly Pro Thr Leu Val Arg Thr Ser 
        35                  40                  45              


Glu Asp Asn Met Thr Asp Met Val Thr His Met Pro Asp Arg Tyr Lys 
    50                  55                  60                  


Ile Val Glu Thr Leu Ile Gln His Ser Asp Trp Phe Phe Ser Asp Glu 
65                  70                  75                  80  


Glu Asp Lys Gly Glu Arg Ile Leu Pro Pro Val Val Gln Pro Ser Pro 
                85                  90                  95      


Arg Val Arg Gly Pro Pro Arg Arg Ser Arg Thr Pro Gly Arg Cys Trp 
            100                 105                 110         


Arg Ser Pro Ser Ser Arg Pro Ser Thr Ala Ser Ala Arg Ser Gly Gly 
        115                 120                 125             


Arg Arg Gly Gly Trp Ala Ala 
    130                 135 


<210>  147
<211>  2087
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Rho 32

<220>
<221>  misc_feature
<223>  or Rho GTPase-activating protein 32 (ARHGAP32)

<400>  147

Met Glu Thr Glu Ser Glu Ser Ser Thr Leu Gly Asp Asp Ser Val Phe 
1               5                   10                  15      


Trp Leu Glu Ser Glu Val Ile Ile Gln Val Thr Asp Cys Glu Glu Glu 
            20                  25                  30          


Glu Arg Glu Glu Lys Phe Arg Lys Met Lys Ser Ser Val His Ser Glu 
        35                  40                  45              


Glu Asp Asp Phe Val Pro Glu Leu His Arg Asn Val His Pro Arg Glu 
    50                  55                  60                  


Arg Pro Asp Trp Glu Glu Thr Leu Ser Ala Met Ala Arg Gly Ala Asp 
65                  70                  75                  80  


Val Pro Glu Ile Pro Gly Asp Leu Thr Leu Lys Thr Cys Gly Ser Thr 
                85                  90                  95      


Ala Ser Met Lys Val Lys His Val Lys Lys Leu Pro Phe Thr Lys Gly 
            100                 105                 110         


His Phe Pro Lys Met Ala Glu Cys Ala His Phe His Tyr Glu Asn Val 
        115                 120                 125             


Glu Phe Gly Ser Ile Gln Leu Ser Leu Ser Glu Glu Gln Asn Glu Val 
    130                 135                 140                 


Met Lys Asn Gly Cys Glu Ser Lys Glu Leu Val Tyr Leu Val Gln Ile 
145                 150                 155                 160 


Ala Cys Gln Gly Lys Ser Trp Ile Val Lys Arg Ser Tyr Glu Asp Phe 
                165                 170                 175     


Arg Val Leu Asp Lys His Leu His Leu Cys Ile Tyr Asp Arg Arg Phe 
            180                 185                 190         


Ser Gln Leu Ser Glu Leu Pro Arg Ser Asp Thr Leu Lys Asp Ser Pro 
        195                 200                 205             


Glu Ser Val Thr Gln Met Leu Met Ala Tyr Leu Ser Arg Leu Ser Ala 
    210                 215                 220                 


Ile Ala Gly Asn Lys Ile Asn Cys Gly Pro Ala Leu Thr Trp Met Glu 
225                 230                 235                 240 


Ile Asp Asn Lys Gly Asn His Leu Leu Val His Glu Glu Ser Ser Ile 
                245                 250                 255     


Asn Thr Pro Ala Val Gly Ala Ala His Val Ile Lys Arg Tyr Thr Ala 
            260                 265                 270         


Arg Ala Pro Asp Glu Leu Thr Leu Glu Val Gly Asp Ile Val Ser Val 
        275                 280                 285             


Ile Asp Met Pro Pro Lys Val Leu Ser Thr Trp Trp Arg Gly Lys His 
    290                 295                 300                 


Gly Phe Gln Val Gly Leu Phe Pro Gly His Cys Val Glu Leu Ile Asn 
305                 310                 315                 320 


Gln Lys Val Pro Gln Ser Val Thr Asn Ser Val Pro Lys Pro Val Ser 
                325                 330                 335     


Lys Lys His Gly Lys Leu Ile Thr Phe Leu Arg Thr Phe Met Lys Ser 
            340                 345                 350         


Arg Pro Thr Lys Gln Lys Leu Lys Gln Arg Gly Ile Leu Lys Glu Arg 
        355                 360                 365             


Val Phe Gly Cys Asp Leu Gly Glu His Leu Leu Asn Ser Gly Phe Glu 
    370                 375                 380                 


Val Pro Gln Val Leu Gln Ser Cys Thr Ala Phe Ile Glu Arg Tyr Gly 
385                 390                 395                 400 


Ile Val Asp Gly Ile Tyr Arg Leu Ser Gly Val Ala Ser Asn Ile Gln 
                405                 410                 415     


Arg Leu Arg His Glu Phe Asp Ser Glu His Val Pro Asp Leu Thr Lys 
            420                 425                 430         


Glu Pro Tyr Val Gln Asp Ile His Ser Val Gly Ser Leu Cys Lys Leu 
        435                 440                 445             


Tyr Phe Arg Glu Leu Pro Asn Pro Leu Leu Thr Tyr Gln Leu Tyr Glu 
    450                 455                 460                 


Lys Phe Ser Asp Ala Val Ser Ala Ala Thr Asp Glu Glu Arg Leu Ile 
465                 470                 475                 480 


Lys Ile His Asp Val Ile Gln Gln Leu Pro Pro Pro His Tyr Arg Thr 
                485                 490                 495     


Leu Glu Phe Leu Met Arg His Leu Ser Leu Leu Ala Asp Tyr Cys Ser 
            500                 505                 510         


Ile Thr Asn Met His Ala Lys Asn Leu Ala Ile Val Trp Ala Pro Asn 
        515                 520                 525             


Leu Leu Arg Ser Lys Gln Ile Glu Ser Ala Cys Phe Ser Gly Thr Ala 
    530                 535                 540                 


Ala Phe Met Glu Val Arg Ile Gln Ser Val Val Val Glu Phe Ile Leu 
545                 550                 555                 560 


Asn His Val Asp Val Leu Phe Ser Gly Arg Ile Ser Met Ala Met Gln 
                565                 570                 575     


Glu Gly Ala Ala Ser Leu Ser Arg Pro Lys Ser Leu Leu Val Ser Ser 
            580                 585                 590         


Pro Ser Thr Lys Leu Leu Thr Leu Glu Glu Ala Gln Ala Arg Thr Gln 
        595                 600                 605             


Ala Gln Val Asn Ser Pro Ile Val Thr Glu Asn Lys Tyr Ile Glu Val 
    610                 615                 620                 


Gly Glu Gly Pro Ala Ala Leu Gln Gly Lys Phe His Thr Ile Ile Glu 
625                 630                 635                 640 


Phe Pro Leu Glu Arg Lys Arg Pro Gln Asn Lys Met Lys Lys Ser Pro 
                645                 650                 655     


Val Gly Ser Trp Arg Ser Phe Phe Asn Leu Gly Lys Ser Ser Ser Val 
            660                 665                 670         


Ser Lys Arg Lys Leu Gln Arg Asn Glu Ser Glu Pro Ser Glu Met Lys 
        675                 680                 685             


Ala Met Ala Leu Lys Gly Gly Arg Ala Glu Gly Thr Leu Arg Ser Ala 
    690                 695                 700                 


Lys Ser Glu Glu Ser Leu Thr Ser Leu His Ala Val Asp Gly Asp Ser 
705                 710                 715                 720 


Lys Leu Phe Arg Pro Arg Arg Pro Arg Ser Ser Ser Asp Ala Leu Ser 
                725                 730                 735     


Ala Ser Phe Asn Gly Glu Met Leu Gly Asn Arg Cys Asn Ser Tyr Asp 
            740                 745                 750         


Asn Leu Pro His Asp Asn Glu Ser Glu Glu Glu Gly Gly Leu Leu His 
        755                 760                 765             


Ile Pro Ala Leu Met Ser Pro His Ser Ala Glu Asp Val Asp Leu Ser 
    770                 775                 780                 


Pro Pro Asp Ile Gly Val Ala Ser Leu Asp Phe Asp Pro Met Ser Phe 
785                 790                 795                 800 


Gln Cys Ser Pro Pro Lys Ala Glu Ser Glu Cys Leu Glu Ser Gly Ala 
                805                 810                 815     


Ser Phe Leu Asp Ser Pro Gly Tyr Ser Lys Asp Lys Pro Ser Ala Asn 
            820                 825                 830         


Lys Lys Asp Ala Glu Thr Gly Ser Ser Gln Cys Gln Thr Pro Gly Ser 
        835                 840                 845             


Thr Ala Ser Ser Glu Pro Val Ser Pro Leu Gln Glu Lys Leu Ser Pro 
    850                 855                 860                 


Phe Phe Thr Leu Asp Leu Ser Pro Thr Glu Asp Lys Ser Ser Lys Pro 
865                 870                 875                 880 


Ser Ser Phe Thr Glu Lys Val Val Tyr Ala Phe Ser Pro Lys Ile Gly 
                885                 890                 895     


Arg Lys Leu Ser Lys Ser Pro Ser Met Ser Ile Ser Glu Pro Ile Ser 
            900                 905                 910         


Val Thr Leu Pro Pro Arg Val Ser Glu Val Ile Gly Thr Val Ser Asn 
        915                 920                 925             


Thr Thr Ala Gln Asn Ala Ser Ser Ser Thr Trp Asp Lys Cys Val Glu 
    930                 935                 940                 


Glu Arg Asp Ala Thr Asn Arg Ser Pro Thr Gln Ile Val Lys Met Lys 
945                 950                 955                 960 


Thr Asn Glu Thr Val Ala Gln Glu Ala Tyr Glu Ser Glu Val Gln Pro 
                965                 970                 975     


Leu Asp Gln Val Ala Ala Glu Glu Val Glu Leu Pro Gly Lys Glu Asp 
            980                 985                 990         


Gln Ser Val Ser Ser Ser Gln Ser  Lys Ala Val Ala Ser  Gly Gln Thr 
        995                 1000                 1005             


Gln Thr  Gly Ala Val Thr His  Asp Pro Pro Gln Asp  Ser Val Pro 
    1010                 1015                 1020             


Val Ser  Ser Val Ser Leu Ile  Pro Pro Pro Pro Pro  Pro Lys Asn 
    1025                 1030                 1035             


Val Ala  Arg Met Leu Ala Leu  Ala Leu Ala Glu Ser  Ala Gln Gln 
    1040                 1045                 1050             


Ala Ser  Thr Gln Ser Leu Lys  Arg Pro Gly Thr Ser  Gln Ala Gly 
    1055                 1060                 1065             


Tyr Thr  Asn Tyr Gly Asp Ile  Ala Val Ala Thr Thr  Glu Asp Asn 
    1070                 1075                 1080             


Leu Ser  Ser Ser Tyr Ser Ala  Val Ala Leu Asp Lys  Ala Tyr Phe 
    1085                 1090                 1095             


Gln Thr  Asp Arg Pro Ala Glu  Gln Phe His Leu Gln  Asn Asn Ala 
    1100                 1105                 1110             


Pro Gly  Asn Cys Asp His Pro  Leu Pro Glu Thr Thr  Ala Thr Gly 
    1115                 1120                 1125             


Asp Pro  Thr His Ser Asn Thr  Thr Glu Ser Gly Glu  Gln His His 
    1130                 1135                 1140             


Gln Val  Asp Leu Thr Gly Asn  Gln Pro His Gln Ala  Tyr Leu Ser 
    1145                 1150                 1155             


Gly Asp  Pro Glu Lys Ala Arg  Ile Thr Ser Val Pro  Leu Asp Ser 
    1160                 1165                 1170             


Glu Lys  Ser Asp Asp His Val  Ser Phe Pro Glu Asp  Gln Ser Gly 
    1175                 1180                 1185             


Lys Asn  Ser Met Pro Thr Val  Ser Phe Leu Asp Gln  Asp Gln Ser 
    1190                 1195                 1200             


Pro Pro  Arg Phe Tyr Ser Gly  Asp Gln Pro Pro Ser  Tyr Leu Gly 
    1205                 1210                 1215             


Ala Ser  Val Asp Lys Leu His  His Pro Leu Glu Phe  Ala Asp Lys 
    1220                 1225                 1230             


Ser Pro  Thr Pro Pro Asn Leu  Pro Ser Asp Lys Ile  Tyr Pro Pro 
    1235                 1240                 1245             


Ser Gly  Ser Pro Glu Glu Asn  Thr Ser Thr Ala Thr  Met Thr Tyr 
    1250                 1255                 1260             


Met Thr  Thr Thr Pro Ala Thr  Ala Gln Met Ser Thr  Lys Glu Ala 
    1265                 1270                 1275             


Ser Trp  Asp Val Ala Glu Gln  Pro Thr Thr Ala Asp  Phe Ala Ala 
    1280                 1285                 1290             


Ala Thr  Leu Gln Arg Thr His  Arg Thr Asn Arg Pro  Leu Pro Pro 
    1295                 1300                 1305             


Pro Pro  Ser Gln Arg Ser Ala  Glu Gln Pro Pro Val  Val Gly Gln 
    1310                 1315                 1320             


Val Gln  Ala Ala Thr Asn Ile  Gly Leu Asn Asn Ser  His Lys Val 
    1325                 1330                 1335             


Gln Gly  Val Val Pro Val Pro  Glu Arg Pro Pro Glu  Pro Arg Ala 
    1340                 1345                 1350             


Met Asp  Asp Pro Ala Ser Ala  Phe Ile Ser Asp Ser  Gly Ala Ala 
    1355                 1360                 1365             


Ala Ala  Gln Cys Pro Met Ala  Thr Ala Val Gln Pro  Gly Leu Pro 
    1370                 1375                 1380             


Glu Lys  Val Arg Asp Gly Ala  Arg Val Pro Leu Leu  His Leu Arg 
    1385                 1390                 1395             


Ala Glu  Ser Val Pro Ala His  Pro Cys Gly Phe Pro  Ala Pro Leu 
    1400                 1405                 1410             


Pro Pro  Thr Arg Met Met Glu  Ser Lys Met Ile Ala  Ala Ile His 
    1415                 1420                 1425             


Ser Ser  Ser Ala Asp Ala Thr  Ser Ser Ser Asn Tyr  His Ser Phe 
    1430                 1435                 1440             


Val Thr  Ala Ser Ser Thr Ser  Val Asp Asp Ala Leu  Pro Leu Pro 
    1445                 1450                 1455             


Leu Pro  Val Pro Gln Pro Lys  His Ala Ser Gln Lys  Thr Val Tyr 
    1460                 1465                 1470             


Ser Ser  Phe Ala Arg Pro Asp  Val Thr Thr Glu Pro  Phe Gly Pro 
    1475                 1480                 1485             


Asp Asn  Cys Leu His Phe Asn  Met Thr Pro Asn Cys  Gln Tyr Arg 
    1490                 1495                 1500             


Pro Gln  Ser Val Pro Pro His  His Asn Lys Leu Glu  Gln His Gln 
    1505                 1510                 1515             


Val Tyr  Gly Ala Arg Ser Glu  Pro Pro Ala Ser Met  Gly Leu Arg 
    1520                 1525                 1530             


Tyr Asn  Thr Tyr Val Ala Pro  Gly Arg Asn Ala Ser  Gly His His 
    1535                 1540                 1545             


Ser Lys  Pro Cys Ser Arg Val  Glu Tyr Val Ser Ser  Leu Ser Ser 
    1550                 1555                 1560             


Ser Val  Arg Asn Thr Cys Tyr  Pro Glu Asp Ile Pro  Pro Tyr Pro 
    1565                 1570                 1575             


Thr Ile  Arg Arg Val Gln Ser  Leu His Ala Pro Pro  Ser Ser Met 
    1580                 1585                 1590             


Ile Arg  Ser Val Pro Ile Ser  Arg Thr Glu Val Pro  Pro Asp Asp 
    1595                 1600                 1605             


Glu Pro  Ala Tyr Cys Pro Arg  Pro Leu Tyr Gln Tyr  Lys Pro Tyr 
    1610                 1615                 1620             


Gln Ser  Ser Gln Ala Arg Ser  Asp Tyr His Val Thr  Gln Leu Gln 
    1625                 1630                 1635             


Pro Tyr  Phe Glu Asn Gly Arg  Val His Tyr Arg Tyr  Ser Pro Tyr 
    1640                 1645                 1650             


Ser Ser  Ser Ser Ser Ser Tyr  Tyr Ser Pro Asp Gly  Ala Leu Cys 
    1655                 1660                 1665             


Asp Val  Asp Ala Tyr Gly Thr  Val Gln Leu Arg Pro  Leu His Arg 
    1670                 1675                 1680             


Leu Pro  Asn Arg Asp Phe Ala  Phe Tyr Asn Pro Arg  Leu Gln Gly 
    1685                 1690                 1695             


Lys Ser  Leu Tyr Ser Tyr Ala  Gly Leu Ala Pro Arg  Pro Arg Ala 
    1700                 1705                 1710             


Asn Val  Thr Gly Tyr Phe Ser  Pro Asn Asp His Asn  Val Val Ser 
    1715                 1720                 1725             


Met Pro  Pro Ala Ala Asp Val  Lys His Thr Tyr Thr  Ser Trp Asp 
    1730                 1735                 1740             


Leu Glu  Asp Met Glu Lys Tyr  Arg Met Gln Ser Ile  Arg Arg Glu 
    1745                 1750                 1755             


Ser Arg  Ala Arg Gln Lys Val  Lys Gly Pro Val Met  Ser Gln Tyr 
    1760                 1765                 1770             


Asp Asn  Met Thr Pro Ala Val  Gln Asp Asp Leu Gly  Gly Ile Tyr 
    1775                 1780                 1785             


Val Ile  His Leu Arg Ser Lys  Ser Asp Pro Gly Lys  Thr Gly Leu 
    1790                 1795                 1800             


Leu Ser  Val Ala Glu Gly Lys  Glu Ser Arg His Ala  Ala Lys Ala 
    1805                 1810                 1815             


Ile Ser  Pro Glu Gly Glu Asp  Arg Phe Tyr Arg Arg  His Pro Glu 
    1820                 1825                 1830             


Ala Glu  Met Asp Arg Ala His  His His Gly Gly His  Gly Ser Thr 
    1835                 1840                 1845             


Gln Pro  Glu Lys Pro Ser Leu  Pro Gln Lys Gln Ser  Ser Leu Arg 
    1850                 1855                 1860             


Ser Arg  Lys Leu Pro Asp Met  Gly Cys Ser Leu Pro  Glu His Arg 
    1865                 1870                 1875             


Ala His  Gln Glu Ala Ser His  Arg Gln Phe Cys Glu  Ser Lys Asn 
    1880                 1885                 1890             


Gly Pro  Pro Tyr Pro Gln Gly  Ala Gly Gln Leu Asp  Tyr Gly Ser 
    1895                 1900                 1905             


Lys Gly  Ile Pro Asp Thr Ser  Glu Pro Val Ser Tyr  His Asn Ser 
    1910                 1915                 1920             


Gly Val  Lys Tyr Ala Ala Ser  Gly Gln Glu Ser Leu  Arg Leu Asn 
    1925                 1930                 1935             


His Lys  Glu Val Arg Leu Ser  Lys Glu Met Glu Arg  Pro Trp Val 
    1940                 1945                 1950             


Arg Gln  Pro Ser Ala Pro Glu  Lys His Ser Arg Asp  Cys Tyr Lys 
    1955                 1960                 1965             


Glu Glu  Glu His Leu Thr Gln  Ser Ile Val Pro Pro  Pro Lys Pro 
    1970                 1975                 1980             


Glu Arg  Ser His Ser Leu Lys  Leu His His Thr Gln  Asn Val Glu 
    1985                 1990                 1995             


Arg Asp  Pro Ser Val Leu Tyr  Gln Tyr Gln Pro His  Gly Lys Arg 
    2000                 2005                 2010             


Gln Ser  Ser Val Thr Val Val  Ser Gln Tyr Asp Asn  Leu Glu Asp 
    2015                 2020                 2025             


Tyr His  Ser Leu Pro Gln His  Gln Arg Gly Val Phe  Gly Gly Gly 
    2030                 2035                 2040             


Gly Met  Gly Thr Tyr Val Pro  Pro Gly Phe Pro His  Pro Gln Ser 
    2045                 2050                 2055             


Arg Thr  Tyr Ala Thr Ala Leu  Gly Gln Gly Ala Phe  Leu Pro Ala 
    2060                 2065                 2070             


Glu Leu  Ser Leu Gln His Pro  Glu Thr Gln Ile His  Ala Glu 
    2075                 2080                 2085         


