                         SEQUENCE LISTING

<110>  BioNTech RNA Pharmaceuticals GmbH et al.
 
<120>  THERAPEUTIC RNA FOR OVARIAN CANCER

<130>  674-283 PCT2

<150>  PCT/EP2019/062967
<151>  2019-05-20

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLDN6

<400>  1

Met Ala Ser Ala Gly Met Gln Ile Leu Gly Val Val Leu Thr Leu Leu 
1               5                   10                  15      


Gly Trp Val Asn Gly Leu Val Ser Cys Ala Leu Pro Met Trp Lys Val 
            20                  25                  30          


Thr Ala Phe Ile Gly Asn Ser Ile Val Val Ala Gln Val Val Trp Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys 
    50                  55                  60                  


Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Cys Val Ile Ala Leu Leu Val Ala Leu Phe Gly Leu Leu 
                85                  90                  95      


Val Tyr Leu Ala Gly Ala Lys Cys Thr Thr Cys Val Glu Glu Lys Asp 
            100                 105                 110         


Ser Lys Ala Arg Leu Val Leu Thr Ser Gly Ile Val Phe Val Ile Ser 
        115                 120                 125             


Gly Val Leu Thr Leu Ile Pro Val Cys Trp Thr Ala His Ala Ile Ile 
    130                 135                 140                 


Arg Asp Phe Tyr Asn Pro Leu Val Ala Glu Ala Gln Lys Arg Glu Leu 
145                 150                 155                 160 


Gly Ala Ser Leu Tyr Leu Gly Trp Ala Ala Ser Gly Leu Leu Leu Leu 
                165                 170                 175     


Gly Gly Gly Leu Leu Cys Cys Thr Cys Pro Ser Gly Gly Ser Gln Gly 
            180                 185                 190         


Pro Ser His Tyr Met Ala Arg Tyr Ser Thr Ser Ala Pro Ala Ile Ser 
        195                 200                 205             


Arg Gly Pro Ser Glu Tyr Pro Thr Lys Asn Tyr Val 
    210                 215                 220 


<210>  2
<211>  663
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CLDN6 CDS

<400>  2
auggccucug ccggaaugca gauccugggc guggugcuga cccugcuggg cugggugaau       60

ggccugguga gcugugcccu gcccaugugg aaggugacag ccuucauugg caacagcauu      120

gugguggccc agguggugug ggagggccug uggaugagcu guguggugca gagcacaggc      180

cagaugcagu gcaaggugua ugacagccug cuggcccugc cucaggaccu ccaggccgcc      240

agagcccugu gugugauugc ccugcuggug gcccuguuug gccugcuggu guaccuggcu      300

ggagccaagu gcaccaccug uguggaggag aaggacagca aggccagacu ggugcugacc      360

ucuggcauug uguuugugau cucuggcgug cugacccuga ucccugugug cuggacagcc      420

caugccauca ucagagacuu cuacaacccu cugguggccg aggcccagaa aagagagcug      480

ggagccagcc uguaccuggg cugggccgcc ucuggccuuc uucugcuggg aggaggacug      540

cugugcugca ccugccccuc uggcggcagc cagggcccca gccacuacau ggccagauac      600

agcaccucug ccccugccau cagcagaggc ccuucugagu accccaccaa gaacuaugug      660

uga                                                                    663


<210>  3
<211>  1146
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CLDN6 RNA

<400>  3
gggcgaacua guauucuucu gguccccaca gacucagaga gaacccgcca ccauggccuc       60

ugccggaaug cagauccugg gcguggugcu gacccugcug ggcuggguga auggccuggu      120

gagcugugcc cugcccaugu ggaaggugac agccuucauu ggcaacagca uugugguggc      180

ccagguggug ugggagggcc uguggaugag cuguguggug cagagcacag gccagaugca      240

gugcaaggug uaugacagcc ugcuggcccu gccucaggac cuccaggccg ccagagcccu      300

gugugugauu gcccugcugg uggcccuguu uggccugcug guguaccugg cuggagccaa      360

gugcaccacc uguguggagg agaaggacag caaggccaga cuggugcuga ccucuggcau      420

uguguuugug aucucuggcg ugcugacccu gaucccugug ugcuggacag cccaugccau      480

caucagagac uucuacaacc cucugguggc cgaggcccag aaaagagagc ugggagccag      540

ccuguaccug ggcugggccg ccucuggccu ucuucugcug ggaggaggac ugcugugcug      600

caccugcccc ucuggcggca gccagggccc cagccacuac auggccagau acagcaccuc      660

ugccccugcc aucagcagag gcccuucuga guaccccacc aagaacuaug ugugaggagg      720

auccccucga gagcucgcuu ucuugcuguc caauuucuau uaaagguucc uuuguucccu      780

aaguccaacu acuaaacugg gggauauuau gaagggccuu gagcaucugg auucugccua      840

auaaaaaaca uuuauuuuca uugcugcguc gagagcucgc uuucuugcug uccaauuucu      900

auuaaagguu ccuuuguucc cuaaguccaa cuacuaaacu gggggauauu augaagggcc      960

uugagcaucu ggauucugcc uaauaaaaaa cauuuauuuu cauugcugcg ucgagaccug     1020

guccagaguc gcuagcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaagcau augacuaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

aaaaaa                                                                1146


<210>  4
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P53

<400>  4

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  5
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P53 fusion

<400>  5

Met Arg Val Thr Ala Pro Arg Thr Leu Ile Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser Leu Gln Gly Gly Ser Met 
            20                  25                  30          


Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln Glu 
        35                  40                  45              


Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu Ser 
    50                  55                  60                  


Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg 
                85                  90                  95      


Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro Thr 
            100                 105                 110         


Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser Val 
        115                 120                 125             


Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe 
    130                 135                 140                 


Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala 
145                 150                 155                 160 


Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu 
                165                 170                 175     


Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala 
            180                 185                 190         


Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro 
        195                 200                 205             


His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His 
    210                 215                 220                 


Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg 
225                 230                 235                 240 


Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val 
                245                 250                 255     


Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser 
            260                 265                 270         


Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu 
        275                 280                 285             


Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg 
    290                 295                 300                 


Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu 
305                 310                 315                 320 


Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys 
                325                 330                 335     


Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys 
            340                 345                 350         


Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg 
        355                 360                 365             


Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala 
    370                 375                 380                 


Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His Leu 
385                 390                 395                 400 


Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met Phe 
                405                 410                 415     


Lys Thr Glu Gly Pro Asp Ser Asp Gly Gly Ser Ile Val Gly Ile Val 
            420                 425                 430         


Ala Gly Leu Ala Val Leu Ala Val Val Val Ile Gly Ala Val Val Ala 
        435                 440                 445             


Thr Val Met Cys Arg Arg Lys Ser Ser Gly Gly Lys Gly Gly Ser Tyr 
    450                 455                 460                 


Ser Gln Ala Ala Ser Ser Asp Ser Ala Gln Gly Ser Asp Val Ser Leu 
465                 470                 475                 480 


Thr Ala 
        


<210>  6
<211>  1179
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  P53 CDS

<400>  6
auggaggagc cgcagucaga uccuagcguc gagcccccuc ugagucagga aacauuuuca       60

gaccuaugga aacuacuucc ugaaaacaac guucuguccc ccuugccguc ccaagcaaug      120

gaugauuuga ugcugucccc ggacgauauu gaacaauggu ucacugaaga cccaggucca      180

gaugaagcuc ccagaaugcc agaggcugcu ccccccgugg ccccugcacc agcagcuccu      240

acaccggcgg ccccugcacc agcccccucc uggccccugu caucuucugu cccuucccag      300

aaaaccuacc agggcagcua cgguuuccgu cugggcuucu ugcauucugg gacagccaag      360

ucugugacuu gcacguacuc cccugcccuc aacaagaugu uuugccaacu ggccaagacc      420

ugcccugugc agcugugggu ugauuccaca cccccgcccg gcacccgcgu ccgcgccaug      480

gccaucuaca agcagucaca gcacaugacg gagguuguga ggcgcugccc ccaccaugag      540

cgcugcucag auagcgaugg ucuggccccu ccucagcauc uuauccgagu ggaaggaaau      600

uugcgugugg aguauuugga ugacagaaac acuuuucgac auaguguggu ggugcccuau      660

gagccgccug agguuggcuc ugacuguacc accauccacu acaacuacau guguaacagu      720

uccugcaugg gcggcaugaa ccggaggccc auccucacca ucaucacacu ggaagacucc      780

agugguaauc uacugggacg gaacagcuuu gaggugcgug uuugugccug uccugggaga      840

gaccggcgca cagaggagga aaaucuccgc aagaaagggg agccucacca cgagcugccc      900

ccagggagca cuaagcgagc acugcccaac aacaccagcu ccucucccca gccaaagaag      960

aaaccacugg auggagaaua uuucacccuu cagauccgug ggcgugagcg cuucgagaug     1020

uuccgagagc ugaaugaggc cuuggaacuc aaggaugccc aggcugggaa ggagccaggg     1080

gggagcaggg cucacuccag ccaccugaag uccaaaaagg gucagucuac cucccgccau     1140

aaaaaacuca uguucaagac agaagggccu gacucagac                            1179


<210>  7
<211>  1922
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  P53 RNA

<400>  7
gggcgaacua guauucuucu gguccccaca gacucagaga gaacccgcca ccaugagagu       60

gaccgccccc agaacccuga uccugcugcu gucuggcgcc cuggcccuga cagagacaug      120

ggccggaagc cugcagggag gaagcaugga ggagccgcag ucagauccua gcgucgagcc      180

cccucugagu caggaaacau uuucagaccu auggaaacua cuuccugaaa acaacguucu      240

gucccccuug ccgucccaag caauggauga uuugaugcug uccccggacg auauugaaca      300

augguucacu gaagacccag guccagauga agcucccaga augccagagg cugcuccccc      360

cguggccccu gcaccagcag cuccuacacc ggcggccccu gcaccagccc ccuccuggcc      420

ccugucaucu ucugucccuu cccagaaaac cuaccagggc agcuacgguu uccgucuggg      480

cuucuugcau ucugggacag ccaagucugu gacuugcacg uacuccccug cccucaacaa      540

gauguuuugc caacuggcca agaccugccc ugugcagcug uggguugauu ccacaccccc      600

gcccggcacc cgcguccgcg ccauggccau cuacaagcag ucacagcaca ugacggaggu      660

ugugaggcgc ugcccccacc augagcgcug cucagauagc gauggucugg ccccuccuca      720

gcaucuuauc cgaguggaag gaaauuugcg uguggaguau uuggaugaca gaaacacuuu      780

ucgacauagu gugguggugc ccuaugagcc gccugagguu ggcucugacu guaccaccau      840

ccacuacaac uacaugugua acaguuccug caugggcggc augaaccgga ggcccauccu      900

caccaucauc acacuggaag acuccagugg uaaucuacug ggacggaaca gcuuugaggu      960

gcguguuugu gccuguccug ggagagaccg gcgcacagag gaggaaaauc uccgcaagaa     1020

aggggagccu caccacgagc ugcccccagg gagcacuaag cgagcacugc ccaacaacac     1080

cagcuccucu ccccagccaa agaagaaacc acuggaugga gaauauuuca cccuucagau     1140

ccgugggcgu gagcgcuucg agauguuccg agagcugaau gaggccuugg aacucaagga     1200

ugcccaggcu gggaaggagc caggggggag cagggcucac uccagccacc ugaaguccaa     1260

aaagggucag ucuaccuccc gccauaaaaa acucauguuc aagacagaag ggccugacuc     1320

agacggagga uccaucgugg gaauuguggc aggacuggca gugcuggccg ugguggugau     1380

cggagccgug guggcuaccg ugaugugcag acggaagucc agcggaggca agggcggcag     1440

cuacagccag gccgccagcu cugauagcgc ccagggcagc gacgugucac ugacagccug     1500

acucgagagc ucgcuuucuu gcuguccaau uucuauuaaa gguuccuuug uucccuaagu     1560

ccaacuacua aacuggggga uauuaugaag ggccuugagc aucuggauuc ugccuaauaa     1620

aaaacauuua uuuucauugc ugcgucgaga gcucgcuuuc uugcugucca auuucuauua     1680

aagguuccuu uguucccuaa guccaacuac uaaacugggg gauauuauga agggccuuga     1740

gcaucuggau ucugccuaau aaaaaacauu uauuuucauu gcugcgucga gaccuggucc     1800

agagucgcua gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aagcauauga cuaaaaaaaa     1860

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aa                                                                    1922


<210>  8
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRAME

<400>  8

Met Glu Arg Arg Arg Leu Trp Gly Ser Ile Gln Ser Arg Tyr Ile Ser 
1               5                   10                  15      


Met Ser Val Trp Thr Ser Pro Arg Arg Leu Val Glu Leu Ala Gly Gln 
            20                  25                  30          


Ser Leu Leu Lys Asp Glu Ala Leu Ala Ile Ala Ala Leu Glu Leu Leu 
        35                  40                  45              


Pro Arg Glu Leu Phe Pro Pro Leu Phe Met Ala Ala Phe Asp Gly Arg 
    50                  55                  60                  


His Ser Gln Thr Leu Lys Ala Met Val Gln Ala Trp Pro Phe Thr Cys 
65                  70                  75                  80  


Leu Pro Leu Gly Val Leu Met Lys Gly Gln His Leu His Leu Glu Thr 
                85                  90                  95      


Phe Lys Ala Val Leu Asp Gly Leu Asp Val Leu Leu Ala Gln Glu Val 
            100                 105                 110         


Arg Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Lys Asn Ser 
        115                 120                 125             


His Gln Asp Phe Trp Thr Val Trp Ser Gly Asn Arg Ala Ser Leu Tyr 
    130                 135                 140                 


Ser Phe Pro Glu Pro Glu Ala Ala Gln Pro Met Thr Lys Lys Arg Lys 
145                 150                 155                 160 


Val Asp Gly Leu Ser Thr Glu Ala Glu Gln Pro Phe Ile Pro Val Glu 
                165                 170                 175     


Val Leu Val Asp Leu Phe Leu Lys Glu Gly Ala Cys Asp Glu Leu Phe 
            180                 185                 190         


Ser Tyr Leu Ile Glu Lys Val Lys Arg Lys Lys Asn Val Leu Arg Leu 
        195                 200                 205             


Cys Cys Lys Lys Leu Lys Ile Phe Ala Met Pro Met Gln Asp Ile Lys 
    210                 215                 220                 


Met Ile Leu Lys Met Val Gln Leu Asp Ser Ile Glu Asp Leu Glu Val 
225                 230                 235                 240 


Thr Cys Thr Trp Lys Leu Pro Thr Leu Ala Lys Phe Ser Pro Tyr Leu 
                245                 250                 255     


Gly Gln Met Ile Asn Leu Arg Arg Leu Leu Leu Ser His Ile His Ala 
            260                 265                 270         


Ser Ser Tyr Ile Ser Pro Glu Lys Glu Glu Gln Tyr Ile Ala Gln Phe 
        275                 280                 285             


Thr Ser Gln Phe Leu Ser Leu Gln Cys Leu Gln Ala Leu Tyr Val Asp 
    290                 295                 300                 


Ser Leu Phe Phe Leu Arg Gly Arg Leu Asp Gln Leu Leu Arg His Val 
305                 310                 315                 320 


Met Asn Pro Leu Glu Thr Leu Ser Ile Thr Asn Cys Arg Leu Ser Glu 
                325                 330                 335     


Gly Asp Val Met His Leu Ser Gln Ser Pro Ser Val Ser Gln Leu Ser 
            340                 345                 350         


Val Leu Ser Leu Ser Gly Val Met Leu Thr Asp Val Ser Pro Glu Pro 
        355                 360                 365             


Leu Gln Ala Leu Leu Glu Arg Ala Ser Ala Thr Leu Gln Asp Leu Val 
    370                 375                 380                 


Phe Asp Glu Cys Gly Ile Thr Asp Asp Gln Leu Leu Ala Leu Leu Pro 
385                 390                 395                 400 


Ser Leu Ser His Cys Ser Gln Leu Thr Thr Leu Ser Phe Tyr Gly Asn 
                405                 410                 415     


Ser Ile Ser Ile Ser Ala Leu Gln Ser Leu Leu Gln His Leu Ile Gly 
            420                 425                 430         


Leu Ser Asn Leu Thr His Val Leu Tyr Pro Val Pro Leu Glu Ser Tyr 
        435                 440                 445             


Glu Asp Ile His Gly Thr Leu His Leu Glu Arg Leu Ala Tyr Leu His 
    450                 455                 460                 


Ala Arg Leu Arg Glu Leu Leu Cys Glu Leu Gly Arg Pro Ser Met Val 
465                 470                 475                 480 


Trp Leu Ser Ala Asn Pro Cys Pro His Cys Gly Asp Arg Thr Phe Tyr 
                485                 490                 495     


Asp Pro Glu Pro Ile Leu Cys Pro Cys Phe Met Pro Asn 
            500                 505                 


<210>  9
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRAME fusion

<400>  9

Met Arg Val Thr Ala Pro Arg Thr Leu Ile Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser Leu Gln Gly Gly Ser Met 
            20                  25                  30          


Glu Arg Arg Arg Leu Trp Gly Ser Ile Gln Ser Arg Tyr Ile Ser Met 
        35                  40                  45              


Ser Val Trp Thr Ser Pro Arg Arg Leu Val Glu Leu Ala Gly Gln Ser 
    50                  55                  60                  


Leu Leu Lys Asp Glu Ala Leu Ala Ile Ala Ala Leu Glu Leu Leu Pro 
65                  70                  75                  80  


Arg Glu Leu Phe Pro Pro Leu Phe Met Ala Ala Phe Asp Gly Arg His 
                85                  90                  95      


Ser Gln Thr Leu Lys Ala Met Val Gln Ala Trp Pro Phe Thr Cys Leu 
            100                 105                 110         


Pro Leu Gly Val Leu Met Lys Gly Gln His Leu His Leu Glu Thr Phe 
        115                 120                 125             


Lys Ala Val Leu Asp Gly Leu Asp Val Leu Leu Ala Gln Glu Val Arg 
    130                 135                 140                 


Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Lys Asn Ser His 
145                 150                 155                 160 


Gln Asp Phe Trp Thr Val Trp Ser Gly Asn Arg Ala Ser Leu Tyr Ser 
                165                 170                 175     


Phe Pro Glu Pro Glu Ala Ala Gln Pro Met Thr Lys Lys Arg Lys Val 
            180                 185                 190         


Asp Gly Leu Ser Thr Glu Ala Glu Gln Pro Phe Ile Pro Val Glu Val 
        195                 200                 205             


Leu Val Asp Leu Phe Leu Lys Glu Gly Ala Cys Asp Glu Leu Phe Ser 
    210                 215                 220                 


Tyr Leu Ile Glu Lys Val Lys Arg Lys Lys Asn Val Leu Arg Leu Cys 
225                 230                 235                 240 


Cys Lys Lys Leu Lys Ile Phe Ala Met Pro Met Gln Asp Ile Lys Met 
                245                 250                 255     


Ile Leu Lys Met Val Gln Leu Asp Ser Ile Glu Asp Leu Glu Val Thr 
            260                 265                 270         


Cys Thr Trp Lys Leu Pro Thr Leu Ala Lys Phe Ser Pro Tyr Leu Gly 
        275                 280                 285             


Gln Met Ile Asn Leu Arg Arg Leu Leu Leu Ser His Ile His Ala Ser 
    290                 295                 300                 


Ser Tyr Ile Ser Pro Glu Lys Glu Glu Gln Tyr Ile Ala Gln Phe Thr 
305                 310                 315                 320 


Ser Gln Phe Leu Ser Leu Gln Cys Leu Gln Ala Leu Tyr Val Asp Ser 
                325                 330                 335     


Leu Phe Phe Leu Arg Gly Arg Leu Asp Gln Leu Leu Arg His Val Met 
            340                 345                 350         


Asn Pro Leu Glu Thr Leu Ser Ile Thr Asn Cys Arg Leu Ser Glu Gly 
        355                 360                 365             


Asp Val Met His Leu Ser Gln Ser Pro Ser Val Ser Gln Leu Ser Val 
    370                 375                 380                 


Leu Ser Leu Ser Gly Val Met Leu Thr Asp Val Ser Pro Glu Pro Leu 
385                 390                 395                 400 


Gln Ala Leu Leu Glu Arg Ala Ser Ala Thr Leu Gln Asp Leu Val Phe 
                405                 410                 415     


Asp Glu Cys Gly Ile Thr Asp Asp Gln Leu Leu Ala Leu Leu Pro Ser 
            420                 425                 430         


Leu Ser His Cys Ser Gln Leu Thr Thr Leu Ser Phe Tyr Gly Asn Ser 
        435                 440                 445             


Ile Ser Ile Ser Ala Leu Gln Ser Leu Leu Gln His Leu Ile Gly Leu 
    450                 455                 460                 


Ser Asn Leu Thr His Val Leu Tyr Pro Val Pro Leu Glu Ser Tyr Glu 
465                 470                 475                 480 


Asp Ile His Gly Thr Leu His Leu Glu Arg Leu Ala Tyr Leu His Ala 
                485                 490                 495     


Arg Leu Arg Glu Leu Leu Cys Glu Leu Gly Arg Pro Ser Met Val Trp 
            500                 505                 510         


Leu Ser Ala Asn Pro Cys Pro His Cys Gly Asp Arg Thr Phe Tyr Asp 
        515                 520                 525             


Pro Glu Pro Ile Leu Cys Pro Cys Phe Met Pro Asn Gly Gly Ser Ile 
    530                 535                 540                 


Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val Val Val Ile Gly 
545                 550                 555                 560 


Ala Val Val Ala Thr Val Met Cys Arg Arg Lys Ser Ser Gly Gly Lys 
                565                 570                 575     


Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser Ala Gln Gly Ser 
            580                 585                 590         


Asp Val Ser Leu Thr Ala 
        595             


<210>  10
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PRAME CDS

<400>  10
auggaacgaa ggcguuugug ggguuccauu cagagccgau acaucagcau gagugugugg       60

acaagcccac ggagacuugu ggagcuggca gggcagagcc ugcugaagga ugaggcccug      120

gccauugccg cccuggaguu gcugcccagg gagcuguucc cgccacuguu cauggcagcc      180

uuugacggga gacacagcca gacccugaag gcaauggugc aggccuggcc cuucaccugc      240

cucccucugg gagugcugau gaagggacaa caucuucacc uggagaccuu caaagcugug      300

cuugauggac uugaugugcu ccuugcccag gagguucgcc ccaggaggug gaaacuucaa      360

gugcuggauu uacggaagaa cucucaucag gacuucugga cuguaugguc uggaaacagg      420

gccagucugu acucauuucc agagccagaa gcagcucagc ccaugacaaa gaagcgaaaa      480

guagaugguu ugagcacaga ggcagagcag cccuucauuc caguagaggu gcucguagac      540

cuguuccuca aggaaggugc cugugaugaa uuguucuccu accucauuga gaaagugaag      600

cgaaagaaaa auguacuacg ccugugcugu aagaagcuga agauuuuugc aaugcccaug      660

caggauauca agaugauccu gaaaauggug cagcuggacu cuauugaaga uuuggaagug      720

acuuguaccu ggaagcuacc caccuuggcg aaauuuucuc cuuaccuggg ccagaugauu      780

aaucugcgua gacuccuccu cucccacauc caugcaucuu ccuacauuuc cccggagaag      840

gaggaacagu auaucgccca guucaccucu caguuccuca gucugcagug ccuccaggcu      900

cucuaugugg acucuuuauu uuuccuuaga ggccgccugg aucaguugcu caggcacgug      960

augaaccccu uggaaacccu cucaauaacu aacugccggc uuucggaagg ggaugugaug     1020

caucuguccc agagucccag cgucagucag cuaagugucc ugagucuaag uggggucaug     1080

cugaccgaug uaagucccga gccccuccaa gcucugcugg agagagccuc ugccacccuc     1140

caggaccugg ucuuugauga gugugggauc acggaugauc agcuccuugc ccuccugccu     1200

ucccugagcc acugcuccca gcuuacaacc uuaagcuucu acgggaauuc caucuccaua     1260

ucugccuugc agagucuccu gcagcaccuc aucgggcuga gcaaucugac ccacgugcug     1320

uauccugucc cccuggagag uuaugaggac auccauggua cccuccaccu ggagaggcuu     1380

gccuaucugc augccaggcu cagggaguug cugugugagu uggggcggcc cagcaugguc     1440

uggcuuagug ccaaccccug uccucacugu ggggacagaa ccuucuauga cccggagccc     1500

auccugugcc ccuguuucau gccuaac                                         1527


<210>  11
<211>  2270
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PRAME RNA

<400>  11
gggcgaacua guauucuucu gguccccaca gacucagaga gaacccgcca ccaugagagu       60

gaccgccccc agaacccuga uccugcugcu gucuggcgcc cuggcccuga cagagacaug      120

ggccggaagc cugcagggag gaagcaugga acgaaggcgu uugugggguu ccauucagag      180

ccgauacauc agcaugagug uguggacaag cccacggaga cuuguggagc uggcagggca      240

gagccugcug aaggaugagg cccuggccau ugccgcccug gaguugcugc ccagggagcu      300

guucccgcca cuguucaugg cagccuuuga cgggagacac agccagaccc ugaaggcaau      360

ggugcaggcc uggcccuuca ccugccuccc ucugggagug cugaugaagg gacaacaucu      420

ucaccuggag accuucaaag cugugcuuga uggacuugau gugcuccuug cccaggaggu      480

ucgccccagg agguggaaac uucaagugcu ggauuuacgg aagaacucuc aucaggacuu      540

cuggacugua uggucuggaa acagggccag ucuguacuca uuuccagagc cagaagcagc      600

ucagcccaug acaaagaagc gaaaaguaga ugguuugagc acagaggcag agcagcccuu      660

cauuccagua gaggugcucg uagaccuguu ccucaaggaa ggugccugug augaauuguu      720

cuccuaccuc auugagaaag ugaagcgaaa gaaaaaugua cuacgccugu gcuguaagaa      780

gcugaagauu uuugcaaugc ccaugcagga uaucaagaug auccugaaaa uggugcagcu      840

ggacucuauu gaagauuugg aagugacuug uaccuggaag cuacccaccu uggcgaaauu      900

uucuccuuac cugggccaga ugauuaaucu gcguagacuc cuccucuccc acauccaugc      960

aucuuccuac auuuccccgg agaaggagga acaguauauc gcccaguuca ccucucaguu     1020

ccucagucug cagugccucc aggcucucua uguggacucu uuauuuuucc uuagaggccg     1080

ccuggaucag uugcucaggc acgugaugaa ccccuuggaa acccucucaa uaacuaacug     1140

ccggcuuucg gaaggggaug ugaugcaucu gucccagagu cccagcguca gucagcuaag     1200

uguccugagu cuaagugggg ucaugcugac cgauguaagu cccgagcccc uccaagcucu     1260

gcuggagaga gccucugcca cccuccagga ccuggucuuu gaugagugug ggaucacgga     1320

ugaucagcuc cuugcccucc ugccuucccu gagccacugc ucccagcuua caaccuuaag     1380

cuucuacggg aauuccaucu ccauaucugc cuugcagagu cuccugcagc accucaucgg     1440

gcugagcaau cugacccacg ugcuguaucc ugucccccug gagaguuaug aggacaucca     1500

ugguacccuc caccuggaga ggcuugccua ucugcaugcc aggcucaggg aguugcugug     1560

ugaguugggg cggcccagca uggucuggcu uagugccaac cccuguccuc acugugggga     1620

cagaaccuuc uaugacccgg agcccauccu gugccccugu uucaugccua acggaggauc     1680

caucguggga auuguggcag gacuggcagu gcuggccgug guggugaucg gagccguggu     1740

ggcuaccgug augugcagac ggaaguccag cggaggcaag ggcggcagcu acagccaggc     1800

cgccagcucu gauagcgccc agggcagcga cgugucacug acagccugac ucgagagcuc     1860

gcuuucuugc uguccaauuu cuauuaaagg uuccuuuguu cccuaagucc aacuacuaaa     1920

cugggggaua uuaugaaggg ccuugagcau cuggauucug ccuaauaaaa aacauuuauu     1980

uucauugcug cgucgagagc ucgcuuucuu gcuguccaau uucuauuaaa gguuccuuug     2040

uucccuaagu ccaacuacua aacuggggga uauuaugaag ggccuugagc aucuggauuc     2100

ugccuaauaa aaaacauuua uuuucauugc ugcgucgaga ccugguccag agucgcuagc     2160

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa gcauaugacu aaaaaaaaaa aaaaaaaaaa     2220

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                2270


<210>  12
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TET

<400>  12

Lys Lys Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
1               5                   10                  15      


Leu Lys Lys Leu Gly Gly Gly Lys Arg Gly Gly Gly Lys Lys Met Thr 
            20                  25                  30          


Asn Ser Val Asp Asp Ala Leu Ile Asn Ser Thr Lys Ile Tyr Ser Tyr 
        35                  40                  45              


Phe Pro Ser Val Ile Ser Lys Val Asn Gln Gly Ala Gln Gly Lys Lys 
    50                  55                  60                  


Leu 
65  


<210>  13
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TET fusion

<400>  13

Met Arg Val Thr Ala Pro Arg Thr Leu Ile Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser Leu Gly Ser Leu Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Lys Lys Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile 
        35                  40                  45              


Gly Ile Thr Glu Leu Lys Lys Leu Gly Gly Gly Lys Arg Gly Gly Gly 
    50                  55                  60                  


Lys Lys Met Thr Asn Ser Val Asp Asp Ala Leu Ile Asn Ser Thr Lys 
65                  70                  75                  80  


Ile Tyr Ser Tyr Phe Pro Ser Val Ile Ser Lys Val Asn Gln Gly Ala 
                85                  90                  95      


Gln Gly Lys Lys Leu Gly Ser Ser Gly Gly Gly Gly Ser Pro Gly Gly 
            100                 105                 110         


Gly Ser Ser Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
        115                 120                 125             


Val Val Ile Gly Ala Val Val Ala Thr Val Met Cys Arg Arg Lys Ser 
    130                 135                 140                 


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser 
145                 150                 155                 160 


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
                165                 170 


<210>  14
<211>  195
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TET CDS

<400>  14
aagaagcagu acaucaaggc caacagcaag uucaucggca ucaccgagcu gaagaagcug       60

ggagggggca aacggggagg cggcaaaaag augaccaaca gcguggacga cgcccugauc      120

aacagcacca agaucuacag cuacuucccc agcgugauca gcaaagugaa ccagggcgcu      180

cagggcaaga aacug                                                       195


<210>  15
<211>  986
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TET RNA

<400>  15
gggcgaacua guauucuucu gguccccaca gacucagaga gaacccgcca ccaugagagu       60

gaccgccccc agaacccuga uccugcugcu gucuggcgcc cuggcccuga cagagacaug      120

ggccggaagc cugggauccc ugggaggcgg gggaagcggc aagaagcagu acaucaaggc      180

caacagcaag uucaucggca ucaccgagcu gaagaagcug ggagggggca aacggggagg      240

cggcaaaaag augaccaaca gcguggacga cgcccugauc aacagcacca agaucuacag      300

cuacuucccc agcgugauca gcaaagugaa ccagggcgcu cagggcaaga aacugggcuc      360

uagcggaggg ggaggcucuc cuggcggggg aucuagcauc gugggaauug uggcaggacu      420

ggcagugcug gccguggugg ugaucggagc cgugguggcu accgugaugu gcagacggaa      480

guccagcgga ggcaagggcg gcagcuacag ccaggccgcc agcucugaua gcgcccaggg      540

cagcgacgug ucacugacag ccugacucga gagcucgcuu ucuugcuguc caauuucuau      600

uaaagguucc uuuguucccu aaguccaacu acuaaacugg gggauauuau gaagggccuu      660

gagcaucugg auucugccua auaaaaaaca uuuauuuuca uugcugcguc gagagcucgc      720

uuucuugcug uccaauuucu auuaaagguu ccuuuguucc cuaaguccaa cuacuaaacu      780

gggggauauu augaagggcc uugagcaucu ggauucugcc uaauaaaaaa cauuuauuuu      840

cauugcugcg ucgagaccug guccagaguc gcuagcaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaagcau augacuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaa                                           986


<210>  16
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5'-UTR

<400>  16
gggcgaacua guauucuucu gguccccaca gacucagaga gaacccgcca cc               52


<210>  17
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sec

<400>  17

Met Arg Val Thr Ala Pro Arg Thr Leu Ile Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser 
            20                  25      


<210>  18
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Sec CDS

<400>  18
augagaguga ccgcccccag aacccugauc cugcugcugu cuggcgcccu ggcccugaca       60

gagacauggg ccggaagc                                                     78


<210>  19
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MITD

<400>  19

Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val Val Val Ile 
1               5                   10                  15      


Gly Ala Val Val Ala Thr Val Met Cys Arg Arg Lys Ser Ser Gly Gly 
            20                  25                  30          


Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser Ala Gln Gly 
        35                  40                  45              


Ser Asp Val Ser Leu Thr Ala 
    50                  55  


<210>  20
<211>  168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MITD CDS

<400>  20
aucgugggaa uuguggcagg acuggcagug cuggccgugg uggugaucgg agccguggug       60

gcuaccguga ugugcagacg gaaguccagc ggaggcaagg gcggcagcua cagccaggcc      120

gccagcucug auagcgccca gggcagcgac gugucacuga cagccuga                   168


<210>  21
<211>  311
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3'-UTR

<400>  21
cucgagagcu cgcuuucuug cuguccaauu ucuauuaaag guuccuuugu ucccuaaguc       60

caacuacuaa acugggggau auuaugaagg gccuugagca ucuggauucu gccuaauaaa      120

aaacauuuau uuucauugcu gcgucgagag cucgcuuucu ugcuguccaa uuucuauuaa      180

agguuccuuu guucccuaag uccaacuacu aaacuggggg auauuaugaa gggccuugag      240

caucuggauu cugccuaaua aaaaacauuu auuuucauug cugcgucgag accuggucca      300

gagucgcuag c                                                           311


<210>  22
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  A30L70

<400>  22
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa gcauaugacu aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                 110


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic peptide

<400>  23

Ala Leu Phe Gly Leu Leu Val Tyr Leu 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic peptide

<400>  24

Ala Leu Gln Ser Leu Leu Gln His Leu 
1               5                   


<210>  25
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic peptide

<400>  25

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
1               5                   10                  15  


<210>  26
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic peptide

<400>  26

Met Thr Asn Ser Val Asp Asp Ala Leu Ile Asn Ser Thr Lys Ile Tyr 
1               5                   10                  15      


Ser Tyr Phe Pro Ser Val Ile Ser Lys Val Asn Gln Gly Ala Gln Gly 
            20                  25                  30          


