                               SEQUENCE LISTING

<110> JANSSEN PHARMACEUTICA NV
 
<120> EXPRESSION SYSTEMS AND METHODS OF USE THEREOF

<130> PRD4024WOPCT1

<140>
<141>

<150> 62/849,653
<151> 2019-05-17

<160> 10    

<170> PatentIn version 3.5

<210> 1
<211> 479
<212> PRT
<213> Homo sapiens

<400> 1
Met Asn Trp Ser His Ser Cys Ile Ser Phe Cys Trp Ile Tyr Phe Ala 
1               5                   10                  15      


Ala Ser Arg Leu Arg Ala Ala Glu Thr Ala Asp Gly Lys Tyr Ala Gln 
            20                  25                  30          


Lys Leu Phe Asn Asp Leu Phe Glu Asp Tyr Ser Asn Ala Leu Arg Pro 
        35                  40                  45              


Val Glu Asp Thr Asp Lys Val Leu Asn Val Thr Leu Gln Ile Thr Leu 
    50                  55                  60                  


Ser Gln Ile Lys Asp Met Asp Glu Arg Asn Gln Ile Leu Thr Ala Tyr 
65                  70                  75                  80  


Leu Trp Ile Arg Gln Ile Trp His Asp Ala Tyr Leu Thr Trp Asp Arg 
                85                  90                  95      


Asp Gln Tyr Asp Gly Leu Asp Ser Ile Arg Ile Pro Ser Asp Leu Val 
            100                 105                 110         


Trp Arg Pro Asp Ile Val Leu Tyr Asn Lys Ala Asp Asp Glu Ser Ser 
        115                 120                 125             


Glu Pro Val Asn Thr Asn Val Val Leu Arg Tyr Asp Gly Leu Ile Thr 
    130                 135                 140                 


Trp Asp Ala Pro Ala Ile Thr Lys Ser Ser Cys Val Val Asp Val Thr 
145                 150                 155                 160 


Tyr Phe Pro Phe Asp Asn Gln Gln Cys Asn Leu Thr Phe Gly Ser Trp 
                165                 170                 175     


Thr Tyr Asn Gly Asn Gln Val Asp Ile Phe Asn Ala Leu Asp Ser Gly 
            180                 185                 190         


Asp Leu Ser Asp Phe Ile Glu Asp Val Glu Trp Glu Val His Gly Met 
        195                 200                 205             


Pro Ala Val Lys Asn Val Ile Ser Tyr Gly Cys Cys Ser Glu Pro Tyr 
    210                 215                 220                 


Pro Asp Val Thr Phe Thr Leu Leu Leu Lys Arg Arg Ser Ser Phe Tyr 
225                 230                 235                 240 


Ile Val Asn Leu Leu Ile Pro Cys Val Leu Ile Ser Phe Leu Ala Pro 
                245                 250                 255     


Leu Ser Phe Tyr Leu Pro Ala Ala Ser Gly Glu Lys Val Ser Leu Gly 
            260                 265                 270         


Val Thr Ile Leu Leu Ala Met Thr Val Phe Gln Leu Met Val Ala Glu 
        275                 280                 285             


Ile Met Pro Ala Ser Glu Asn Val Pro Leu Ile Gly Lys Tyr Tyr Ile 
    290                 295                 300                 


Ala Thr Met Ala Leu Ile Thr Ala Ser Thr Ala Leu Thr Ile Met Val 
305                 310                 315                 320 


Met Asn Ile His Phe Cys Gly Ala Glu Ala Arg Pro Val Pro His Trp 
                325                 330                 335     


Ala Arg Val Val Ile Leu Lys Tyr Met Ser Arg Val Leu Phe Val Tyr 
            340                 345                 350         


Asp Val Gly Glu Ser Cys Leu Ser Pro His His Ser Arg Glu Arg Asp 
        355                 360                 365             


His Leu Thr Lys Val Tyr Ser Lys Leu Pro Glu Ser Asn Leu Lys Ala 
    370                 375                 380                 


Ala Arg Asn Lys Asp Leu Ser Arg Lys Lys Asp Met Asn Lys Arg Leu 
385                 390                 395                 400 


Lys Asn Asp Leu Gly Cys Gln Gly Lys Asn Pro Gln Glu Ala Glu Ser 
                405                 410                 415     


Tyr Cys Ala Gln Tyr Lys Val Leu Thr Arg Asn Ile Glu Tyr Ile Ala 
            420                 425                 430         


Lys Cys Leu Lys Asp His Lys Ala Thr Asn Ser Lys Gly Ser Glu Trp 
        435                 440                 445             


Lys Lys Val Ala Lys Val Ile Asp Arg Phe Phe Met Trp Ile Phe Phe 
    450                 455                 460                 


Ile Met Val Phe Val Met Thr Ile Leu Ile Ile Ala Arg Ala Asp 
465                 470                 475                 


<210> 2
<211> 450
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Leu Arg Ser His His Leu Ser Leu Gly Leu Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Ala Glu Cys Leu Gly Ala Glu Gly Arg Leu Ala Leu Lys 
            20                  25                  30          


Leu Phe Arg Asp Leu Phe Ala Asn Tyr Thr Ser Ala Leu Arg Pro Val 
        35                  40                  45              


Ala Asp Thr Asp Gln Thr Leu Asn Val Thr Leu Glu Val Thr Leu Ser 
    50                  55                  60                  


Gln Ile Ile Asp Met Asp Glu Arg Asn Gln Val Leu Thr Leu Tyr Leu 
65                  70                  75                  80  


Trp Ile Arg Gln Glu Trp Thr Asp Ala Tyr Leu Arg Trp Asp Pro Asn 
                85                  90                  95      


Ala Tyr Gly Gly Leu Asp Ala Ile Arg Ile Pro Ser Ser Leu Val Trp 
            100                 105                 110         


Arg Pro Asp Ile Val Leu Tyr Asn Lys Ala Asp Ala Gln Pro Pro Gly 
        115                 120                 125             


Ser Ala Ser Thr Asn Val Val Leu Arg His Asp Gly Ala Val Arg Trp 
    130                 135                 140                 


Asp Ala Pro Ala Ile Thr Arg Ser Ser Cys Arg Val Asp Val Ala Ala 
145                 150                 155                 160 


Phe Pro Phe Asp Ala Gln His Cys Gly Leu Thr Phe Gly Ser Trp Thr 
                165                 170                 175     


His Gly Gly His Gln Leu Asp Val Arg Pro Arg Gly Ala Ala Ala Ser 
            180                 185                 190         


Leu Ala Asp Phe Val Glu Asn Val Glu Trp Arg Val Leu Gly Met Pro 
        195                 200                 205             


Ala Arg Arg Arg Val Leu Thr Tyr Gly Cys Cys Ser Glu Pro Tyr Pro 
    210                 215                 220                 


Asp Val Thr Phe Thr Leu Leu Leu Arg Arg Arg Ala Ala Ala Tyr Val 
225                 230                 235                 240 


Cys Asn Leu Leu Leu Pro Cys Val Leu Ile Ser Leu Leu Ala Pro Leu 
                245                 250                 255     


Ala Phe His Leu Pro Ala Asp Ser Gly Glu Lys Val Ser Leu Gly Val 
            260                 265                 270         


Thr Val Leu Leu Ala Leu Thr Val Phe Gln Leu Leu Leu Ala Glu Ser 
        275                 280                 285             


Met Pro Pro Ala Glu Ser Val Pro Leu Ile Gly Lys Tyr Tyr Met Ala 
    290                 295                 300                 


Thr Met Thr Met Val Thr Phe Ser Thr Ala Leu Thr Ile Leu Ile Met 
305                 310                 315                 320 


Asn Leu His Tyr Cys Gly Pro Ser Val Arg Pro Val Pro Ala Trp Ala 
                325                 330                 335     


Arg Ala Leu Leu Leu Gly His Leu Ala Arg Gly Leu Cys Val Arg Glu 
            340                 345                 350         


Arg Gly Glu Pro Cys Gly Gln Ser Arg Pro Pro Glu Leu Ser Pro Ser 
        355                 360                 365             


Pro Gln Ser Pro Glu Gly Gly Ala Gly Pro Pro Ala Gly Pro Cys His 
    370                 375                 380                 


Glu Pro Arg Cys Leu Cys Arg Gln Glu Ala Leu Leu His His Val Ala 
385                 390                 395                 400 


Thr Ile Ala Asn Thr Phe Arg Ser His Arg Ala Ala Gln Arg Cys His 
                405                 410                 415     


Glu Asp Trp Lys Arg Leu Ala Arg Val Met Asp Arg Phe Phe Leu Ala 
            420                 425                 430         


Ile Phe Phe Ser Met Ala Leu Val Met Ser Leu Leu Val Leu Val Gln 
        435                 440                 445             


Ala Leu 
    450 


<210> 3
<211> 630
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Ala Lys Thr Pro Ser Ser Glu Glu Ser Gly Leu Pro Lys Leu 
1               5                   10                  15      


Pro Val Pro Pro Leu Gln Gln Thr Leu Ala Thr Tyr Leu Gln Cys Met 
            20                  25                  30          


Arg His Leu Val Ser Glu Glu Gln Phe Arg Lys Ser Gln Ala Ile Val 
        35                  40                  45              


Gln Gln Phe Gly Ala Pro Gly Gly Leu Gly Glu Thr Leu Gln Gln Lys 
    50                  55                  60                  


Leu Leu Glu Arg Gln Glu Lys Thr Ala Asn Trp Val Ser Glu Tyr Trp 
65                  70                  75                  80  


Leu Asn Asp Met Tyr Leu Asn Asn Arg Leu Ala Leu Pro Val Asn Ser 
                85                  90                  95      


Ser Pro Ala Val Ile Phe Ala Arg Gln His Phe Pro Gly Thr Asp Asp 
            100                 105                 110         


Gln Leu Arg Phe Ala Ala Ser Leu Ile Ser Gly Val Leu Ser Tyr Lys 
        115                 120                 125             


Ala Leu Leu Asp Ser His Ser Ile Pro Thr Asp Cys Ala Lys Gly Gln 
    130                 135                 140                 


Leu Ser Gly Gln Pro Leu Cys Met Lys Gln Tyr Tyr Gly Leu Phe Ser 
145                 150                 155                 160 


Ser Tyr Arg Leu Pro Gly His Thr Gln Asp Thr Leu Val Ala Gln Asn 
                165                 170                 175     


Ser Ser Ile Met Pro Glu Pro Glu His Val Ile Val Ala Cys Cys Asn 
            180                 185                 190         


Gln Phe Phe Val Leu Asp Val Val Ile Asn Phe Arg Arg Leu Ser Glu 
        195                 200                 205             


Gly Asp Leu Phe Thr Gln Leu Arg Lys Ile Val Lys Met Ala Ser Asn 
    210                 215                 220                 


Glu Asp Glu Arg Leu Pro Pro Ile Gly Leu Leu Thr Ser Asp Gly Arg 
225                 230                 235                 240 


Ser Glu Trp Ala Glu Ala Arg Thr Val Leu Val Lys Asp Ser Thr Asn 
                245                 250                 255     


Arg Asp Ser Leu Asp Met Ile Glu Arg Cys Ile Cys Leu Val Cys Leu 
            260                 265                 270         


Asp Ala Pro Gly Gly Val Glu Leu Ser Asp Thr His Arg Ala Leu Gln 
        275                 280                 285             


Leu Leu His Gly Gly Gly Tyr Ser Lys Asn Gly Ala Asn Arg Trp Tyr 
    290                 295                 300                 


Asp Lys Ser Leu Gln Phe Val Val Gly Arg Asp Gly Thr Cys Gly Val 
305                 310                 315                 320 


Val Cys Glu His Ser Pro Phe Asp Gly Ile Val Leu Val Gln Cys Thr 
                325                 330                 335     


Glu His Leu Leu Lys His Met Thr Gln Ser Ser Arg Lys Leu Ile Arg 
            340                 345                 350         


Ala Asp Ser Val Ser Glu Leu Pro Ala Pro Arg Arg Leu Arg Trp Lys 
        355                 360                 365             


Cys Ser Pro Glu Ile Gln Gly His Leu Ala Ser Ser Ala Glu Lys Leu 
    370                 375                 380                 


Gln Arg Ile Val Lys Asn Leu Asp Phe Ile Val Tyr Lys Phe Asp Asn 
385                 390                 395                 400 


Tyr Gly Lys Thr Phe Ile Lys Lys Gln Lys Cys Ser Pro Asp Ala Phe 
                405                 410                 415     


Ile Gln Val Ala Leu Gln Leu Ala Phe Tyr Arg Leu His Arg Arg Leu 
            420                 425                 430         


Val Pro Thr Tyr Glu Ser Ala Ser Ile Arg Arg Phe Gln Glu Gly Arg 
        435                 440                 445             


Val Asp Asn Ile Arg Ser Ala Thr Pro Glu Ala Leu Ala Phe Val Arg 
    450                 455                 460                 


Ala Val Thr Asp His Lys Ala Ala Val Pro Ala Ser Glu Lys Leu Leu 
465                 470                 475                 480 


Leu Leu Lys Asp Ala Ile Arg Ala Gln Thr Ala Tyr Thr Val Met Ala 
                485                 490                 495     


Ile Thr Gly Met Ala Ile Asp Asn His Leu Leu Ala Leu Arg Glu Leu 
            500                 505                 510         


Ala Arg Ala Met Cys Lys Glu Leu Pro Glu Met Phe Met Asp Glu Thr 
        515                 520                 525             


Tyr Leu Met Ser Asn Arg Phe Val Leu Ser Thr Ser Gln Val Pro Thr 
    530                 535                 540                 


Thr Thr Glu Met Phe Cys Cys Tyr Gly Pro Val Val Pro Asn Gly Tyr 
545                 550                 555                 560 


Gly Ala Cys Tyr Asn Pro Gln Pro Glu Thr Ile Leu Phe Cys Ile Ser 
                565                 570                 575     


Ser Phe His Ser Cys Lys Glu Thr Ser Ser Ser Lys Phe Ala Lys Ala 
            580                 585                 590         


Val Glu Glu Ser Leu Ile Asp Met Arg Asp Leu Cys Ser Leu Leu Pro 
        595                 600                 605             


Pro Thr Glu Ser Lys Pro Leu Ala Thr Lys Glu Lys Ala Thr Arg Pro 
    610                 615                 620                 


Ser Gln Gly His Gln Pro 
625                 630 


<210> 4
<211> 156
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Gly Trp Pro Gly Ala Gly Pro Leu Cys Val Leu Gly Gly Ala 
1               5                   10                  15      


Ala Leu Gly Val Cys Leu Ala Gly Val Ala Gly Gln Leu Val Glu Pro 
            20                  25                  30          


Ser Thr Ala Pro Pro Lys Pro Lys Pro Pro Pro Leu Thr Lys Glu Thr 
        35                  40                  45              


Val Val Phe Trp Asp Met Arg Leu Trp His Val Val Gly Ile Phe Ser 
    50                  55                  60                  


Leu Phe Val Leu Ser Ile Ile Ile Thr Leu Cys Cys Val Phe Asn Cys 
65                  70                  75                  80  


Arg Val Pro Arg Thr Arg Lys Glu Ile Glu Ala Arg Tyr Leu Gln Arg 
                85                  90                  95      


Lys Ala Ala Lys Met Tyr Thr Asp Lys Leu Glu Thr Val Pro Pro Leu 
            100                 105                 110         


Asn Glu Leu Thr Glu Val Pro Gly Glu Asp Lys Lys Lys Lys Lys Lys 
        115                 120                 125             


Lys Lys Lys Asp Ser Val Asp Thr Val Ala Ile Lys Val Glu Glu Asp 
    130                 135                 140                 


Glu Lys Asn Glu Ala Lys Lys Lys Lys Gly Glu Lys 
145                 150                 155     


<210> 5
<211> 1023
<212> PRT
<213> Homo sapiens

<400> 5
Met Cys Ala Arg Met Ala Gly Arg Thr Thr Ala Ala Pro Arg Gly Pro 
1               5                   10                  15      


Tyr Gly Pro Trp Leu Cys Leu Leu Val Ala Leu Ala Leu Asp Val Val 
            20                  25                  30          


Arg Val Asp Cys Gly Gln Ala Pro Leu Asp Pro Val Tyr Leu Pro Ala 
        35                  40                  45              


Ala Leu Glu Leu Leu Asp Ala Pro Glu His Phe Arg Val Gln Gln Val 
    50                  55                  60                  


Gly His Tyr Pro Pro Ala Asn Ser Ser Leu Ser Ser Arg Ser Glu Thr 
65                  70                  75                  80  


Phe Leu Leu Leu Gln Pro Trp Pro Arg Ala Gln Pro Leu Leu Arg Ala 
                85                  90                  95      


Ser Tyr Pro Pro Phe Ala Thr Gln Gln Val Val Pro Pro Arg Val Thr 
            100                 105                 110         


Glu Pro His Gln Arg Pro Val Pro Trp Asp Val Arg Ala Val Ser Val 
        115                 120                 125             


Glu Ala Ala Val Thr Pro Ala Glu Pro Tyr Ala Arg Val Leu Phe His 
    130                 135                 140                 


Leu Lys Gly Gln Asp Trp Pro Pro Gly Ser Gly Ser Leu Pro Cys Ala 
145                 150                 155                 160 


Arg Leu His Ala Thr His Pro Ala Gly Thr Ala His Gln Ala Cys Arg 
                165                 170                 175     


Phe Gln Pro Ser Leu Gly Ala Cys Val Val Glu Leu Glu Leu Pro Ser 
            180                 185                 190         


His Trp Phe Ser Gln Ala Ser Thr Thr Arg Ala Glu Leu Ala Tyr Thr 
        195                 200                 205             


Leu Glu Pro Ala Ala Glu Gly Pro Gly Gly Cys Gly Ser Gly Glu Glu 
    210                 215                 220                 


Asn Asp Pro Gly Glu Gln Ala Leu Pro Val Gly Gly Val Glu Leu Arg 
225                 230                 235                 240 


Pro Ala Asp Pro Pro Gln Tyr Gln Glu Val Pro Leu Asp Glu Ala Val 
                245                 250                 255     


Thr Leu Arg Val Pro Asp Met Pro Val Arg Pro Gly Gln Leu Phe Ser 
            260                 265                 270         


Ala Thr Leu Leu Leu Arg His Asn Phe Thr Ala Ser Leu Leu Thr Leu 
        275                 280                 285             


Arg Ile Lys Val Lys Lys Gly Leu His Val Thr Ala Ala Arg Pro Ala 
    290                 295                 300                 


Gln Pro Thr Leu Trp Thr Ala Lys Leu Asp Arg Phe Lys Gly Ser Arg 
305                 310                 315                 320 


His His Thr Thr Leu Ile Thr Cys His Arg Ala Gly Leu Thr Glu Pro 
                325                 330                 335     


Asp Ser Ser Pro Leu Glu Leu Ser Glu Phe Leu Trp Val Asp Phe Val 
            340                 345                 350         


Val Glu Asn Ser Thr Gly Gly Gly Val Ala Val Thr Arg Pro Val Thr 
        355                 360                 365             


Trp Gln Leu Glu Tyr Pro Gly Gln Ala Pro Glu Ala Glu Lys Asp Lys 
    370                 375                 380                 


Met Val Trp Glu Ile Leu Val Ser Glu Arg Asp Ile Arg Ala Leu Ile 
385                 390                 395                 400 


Pro Leu Ala Lys Ala Glu Glu Leu Val Asn Thr Ala Pro Leu Thr Gly 
                405                 410                 415     


Val Pro Gln His Val Pro Val Arg Leu Val Thr Val Asp Gly Gly Gly 
            420                 425                 430         


Ala Leu Val Glu Val Thr Glu His Val Gly Cys Glu Ser Ala Asn Thr 
        435                 440                 445             


Gln Val Leu Gln Val Ser Glu Ala Cys Asp Ala Val Phe Val Ala Gly 
    450                 455                 460                 


Lys Glu Ser Arg Gly Ala Arg Gly Val Arg Val Asp Phe Trp Trp Arg 
465                 470                 475                 480 


Arg Leu Arg Ala Ser Leu Arg Leu Thr Val Trp Ala Pro Leu Leu Pro 
                485                 490                 495     


Leu Arg Ile Glu Leu Thr Asp Thr Thr Leu Glu Gln Val Arg Gly Trp 
            500                 505                 510         


Arg Val Pro Gly Pro Ala Glu Gly Pro Ala Glu Pro Ala Ala Glu Ala 
        515                 520                 525             


Ser Asp Glu Ala Glu Arg Arg Ala Arg Gly Cys His Leu Gln Tyr Gln 
    530                 535                 540                 


Arg Ala Gly Val Arg Phe Leu Ala Pro Phe Ala Ala His Pro Leu Asp 
545                 550                 555                 560 


Gly Gly Arg Arg Leu Thr His Leu Leu Gly Pro Asp Trp Leu Leu Asp 
                565                 570                 575     


Val Ser His Leu Val Ala Pro His Ala Arg Val Leu Asp Ser Arg Val 
            580                 585                 590         


Ala Ser Leu Glu Gly Gly Arg Val Val Val Gly Arg Glu Pro Gly Val 
        595                 600                 605             


Thr Ser Ile Glu Val Arg Ser Pro Leu Ser Asp Ser Ile Leu Gly Glu 
    610                 615                 620                 


Gln Ala Leu Ala Val Thr Asp Asp Lys Val Ser Val Leu Glu Leu Arg 
625                 630                 635                 640 


Val Gln Pro Val Met Gly Ile Ser Leu Thr Leu Ser Arg Gly Thr Ala 
                645                 650                 655     


His Pro Gly Glu Val Thr Ala Thr Cys Trp Ala Gln Ser Ala Leu Pro 
            660                 665                 670         


Ala Pro Lys Gln Glu Val Ala Leu Ser Leu Trp Leu Ser Phe Ser Asp 
        675                 680                 685             


His Thr Val Ala Pro Ala Glu Leu Tyr Asp Arg Arg Asp Leu Gly Leu 
    690                 695                 700                 


Ser Val Ser Ala Glu Glu Pro Gly Ala Ile Leu Pro Ala Glu Glu Gln 
705                 710                 715                 720 


Gly Ala Gln Leu Gly Val Val Val Ser Gly Ala Gly Ala Glu Gly Leu 
                725                 730                 735     


Pro Leu His Val Ala Leu His Pro Pro Glu Pro Cys Arg Arg Gly Arg 
            740                 745                 750         


His Arg Val Pro Leu Ala Ser Gly Thr Ala Trp Leu Gly Leu Pro Pro 
        755                 760                 765             


Ala Ser Thr Pro Ala Pro Ala Leu Pro Ser Ser Pro Ala Trp Ser Pro 
    770                 775                 780                 


Pro Ala Thr Glu Ala Thr Met Gly Gly Lys Arg Gln Val Ala Gly Ser 
785                 790                 795                 800 


Val Gly Gly Asn Thr Gly Val Arg Gly Lys Phe Glu Arg Ala Glu Glu 
                805                 810                 815     


Glu Ala Arg Lys Glu Glu Thr Glu Ala Arg Glu Glu Glu Glu Glu Glu 
            820                 825                 830         


Glu Glu Glu Met Val Pro Ala Pro Gln His Val Thr Glu Leu Glu Leu 
        835                 840                 845             


Gly Met Tyr Ala Leu Leu Gly Val Phe Cys Val Ala Ile Phe Ile Phe 
    850                 855                 860                 


Leu Val Asn Gly Val Val Phe Val Leu Arg Tyr Gln Arg Lys Glu Pro 
865                 870                 875                 880 


Pro Asp Ser Ala Thr Asp Pro Thr Ser Pro Gln Pro His Asn Trp Val 
                885                 890                 895     


Trp Leu Gly Thr Asp Gln Glu Glu Leu Ser Arg Gln Leu Asp Arg Gln 
            900                 905                 910         


Ser Pro Gly Pro Pro Lys Gly Glu Gly Ser Cys Pro Cys Glu Ser Gly 
        915                 920                 925             


Gly Gly Gly Glu Ala Pro Thr Leu Ala Pro Gly Pro Pro Gly Gly Thr 
    930                 935                 940                 


Thr Ser Ser Ser Ser Thr Leu Ala Arg Lys Glu Ala Gly Gly Arg Arg 
945                 950                 955                 960 


Lys Arg Val Glu Phe Val Thr Phe Ala Pro Ala Pro Pro Ala Gln Ser 
                965                 970                 975     


Pro Glu Glu Pro Val Gly Ala Pro Ala Val Gln Ser Ile Leu Val Ala 
            980                 985                 990         


Gly Glu Glu Asp Ile Arg Trp Val  Cys Glu Asp Met Gly  Leu Lys Asp 
        995                 1000                 1005             


Pro Glu  Glu Leu Arg Asn Tyr  Met Glu Arg Ile Arg  Gly Ser Ser 
    1010                 1015                 1020             


<210> 6
<211> 1108
<212> PRT
<213> Homo sapiens

<400> 6
Met Arg Ser Glu Gly Ala Ala Pro Gly Pro Ala Ala Pro Leu Cys Gly 
1               5                   10                  15      


Ala Leu Ser Leu Leu Leu Gly Ala Leu Leu Gly Lys Val Ile Glu Gly 
            20                  25                  30          


His Gly Val Thr Asp Asn Ile Gln Arg Phe Ser Ser Leu Pro Pro Tyr 
        35                  40                  45              


Leu Pro Val Ser Tyr His Ile Leu Arg Ala Glu Thr Ser Phe Phe Leu 
    50                  55                  60                  


Lys Glu Ala Asn Gln Asp Leu Leu Arg Asn Ser Ser Leu Gln Ala Arg 
65                  70                  75                  80  


Val Glu Ser Phe Phe Thr Tyr Lys Thr Arg Gln Pro Pro Val Leu Asn 
                85                  90                  95      


Ala Ser Tyr Gly Pro Phe Ser Val Glu Lys Val Val Pro Leu Asp Leu 
            100                 105                 110         


Met Leu Thr Ser Asn Phe Leu Gly Pro Thr Asn Lys Phe Ser Phe Asp 
        115                 120                 125             


Trp Lys Leu Lys Ala His Ile Leu Arg Asp Lys Val Tyr Leu Ser Arg 
    130                 135                 140                 


Pro Lys Val Gln Val Leu Phe His Ile Met Gly Arg Asp Trp Asp Asp 
145                 150                 155                 160 


His Gly Ala Gly Glu Lys Leu Pro Cys Leu Arg Val Phe Ala Phe Arg 
                165                 170                 175     


Glu Thr Arg Glu Val Arg Gly Ser Cys Arg Leu Lys Gly Asp Leu Gly 
            180                 185                 190         


Leu Cys Val Ala Glu Leu Glu Leu Leu Ser Ser Trp Phe Ser Ala Pro 
        195                 200                 205             


Thr Val Gly Ala Gly Arg Lys Lys Ser Met Asp Gln Pro Glu Gly Thr 
    210                 215                 220                 


Pro Val Glu Leu Tyr Tyr Thr Val His Pro Gly Asn Glu Arg Gly Asp 
225                 230                 235                 240 


Cys Ala Gly Gly Asp Phe Arg Lys Gly Asn Ala Ile Arg Pro Gly Lys 
                245                 250                 255     


Asp Gly Leu Glu Glu Thr Thr Ser His Leu Gln Arg Ile Gly Thr Val 
            260                 265                 270         


Gly Leu Tyr Arg Ala Gln Asp Ser Ala Gln Leu Ser Glu Leu Arg Leu 
        275                 280                 285             


Asp Gly Asn Val Val Ile Trp Leu Pro Ser Arg Pro Val Lys Gln Gly 
    290                 295                 300                 


Glu Val Val Thr Ala Tyr Val Thr Ile Ser Ser Asn Ser Ser Val Asp 
305                 310                 315                 320 


Leu Phe Ile Leu Arg Ala Lys Val Lys Lys Gly Val Asn Ile Leu Ser 
                325                 330                 335     


Ala Gln Thr Arg Glu Pro Arg Gln Trp Gly Val Lys Gln Glu Val Gly 
            340                 345                 350         


Ser Gly Gly Lys His Val Thr Ala Thr Val Ala Cys Gln Arg Leu Gly 
        355                 360                 365             


Pro Ser Pro Arg Asn Arg Ser Ser Ser Leu Phe Asn Glu Val Val Gln 
    370                 375                 380                 


Met Asn Phe Glu Ile Ala Ser Phe Ser Ser Leu Ser Gly Thr Gln Pro 
385                 390                 395                 400 


Ile Thr Trp Gln Val Glu Tyr Pro Arg Lys Gly Thr Thr Asp Ile Ala 
                405                 410                 415     


Val Ser Glu Ile Phe Val Ser Gln Lys Asp Leu Val Gly Ile Val Pro 
            420                 425                 430         


Leu Ala Met Asp Thr Glu Ile Leu Asn Thr Ala Val Leu Thr Gly Lys 
        435                 440                 445             


Thr Val Ala Met Pro Ile Lys Val Val Ser Val Glu Glu Asn Ser Ala 
    450                 455                 460                 


Val Met Asp Ile Ser Glu Ser Val Glu Cys Lys Ser Thr Asp Glu Asp 
465                 470                 475                 480 


Val Ile Lys Val Ser Glu Arg Cys Asp Tyr Ile Phe Val Asn Gly Lys 
                485                 490                 495     


Glu Ile Lys Gly Lys Met Asp Ala Val Val Asn Phe Thr Tyr Gln Tyr 
            500                 505                 510         


Leu Ser Ala Pro Leu Cys Val Thr Val Trp Val Pro Arg Leu Pro Leu 
        515                 520                 525             


Gln Ile Glu Val Ser Asp Thr Glu Leu Ser Gln Ile Lys Gly Trp Arg 
    530                 535                 540                 


Val Pro Ile Val Thr Asn Lys Arg Pro Thr Arg Glu Ser Glu Asp Glu 
545                 550                 555                 560 


Asp Glu Glu Glu Arg Arg Gly Arg Gly Cys Ala Leu Gln Tyr Gln His 
                565                 570                 575     


Ala Thr Val Arg Val Leu Thr Gln Phe Val Ser Glu Gly Ala Gly Pro 
            580                 585                 590         


Trp Gly Gln Pro Asn Tyr Leu Leu Ser Pro Asn Trp Gln Phe Asp Ile 
        595                 600                 605             


Thr His Leu Val Ala Asp Phe Met Lys Leu Glu Glu Pro His Val Ala 
    610                 615                 620                 


Thr Leu Gln Asp Ser Arg Val Leu Val Gly Arg Glu Val Gly Met Thr 
625                 630                 635                 640 


Thr Ile Gln Val Leu Ser Pro Leu Ser Asp Ser Ile Leu Ala Glu Lys 
                645                 650                 655     


Thr Ile Thr Val Leu Asp Asp Lys Val Ser Val Thr Asp Leu Ala Ile 
            660                 665                 670         


Gln Leu Val Ala Gly Leu Ser Val Ala Leu Tyr Pro Asn Ala Glu Asn 
        675                 680                 685             


Ser Lys Ala Val Thr Ala Val Val Thr Ala Glu Glu Val Leu Arg Thr 
    690                 695                 700                 


Pro Lys Gln Glu Ala Val Phe Ser Thr Trp Leu Gln Phe Ser Asp Gly 
705                 710                 715                 720 


Ser Val Thr Pro Leu Asp Ile Tyr Asp Thr Lys Asp Phe Ser Leu Ala 
                725                 730                 735     


Ala Thr Ser Gln Asp Glu Ala Val Val Ser Val Pro Gln Pro Arg Ser 
            740                 745                 750         


Pro Arg Trp Pro Val Val Val Ala Glu Gly Glu Gly Gln Gly Pro Leu 
        755                 760                 765             


Ile Arg Val Asp Met Thr Ile Ala Glu Ala Cys Gln Lys Ser Lys Arg 
    770                 775                 780                 


Lys Ser Ile Leu Ala Val Gly Val Gly Asn Val Arg Val Lys Phe Gly 
785                 790                 795                 800 


Gln Asn Asp Ala Asp Ser Ser Pro Gly Gly Asp Tyr Glu Glu Asp Glu 
                805                 810                 815     


Ile Lys Asn His Ala Ser Asp Arg Arg Gln Lys Gly Gln His His Glu 
            820                 825                 830         


Arg Thr Gly Gln Asp Gly His Leu Tyr Gly Ser Ser Pro Val Glu Arg 
        835                 840                 845             


Glu Glu Gly Ala Leu Arg Arg Ala Thr Thr Thr Ala Arg Ser Leu Leu 
    850                 855                 860                 


Asp Asn Lys Val Val Lys Asn Ser Arg Ala Asp Gly Gly Arg Leu Ala 
865                 870                 875                 880 


Gly Glu Gly Gln Leu Gln Asn Ile Pro Ile Asp Phe Thr Asn Phe Pro 
                885                 890                 895     


Ala His Val Asp Leu Pro Lys Ala Gly Ser Gly Leu Glu Glu Asn Asp 
            900                 905                 910         


Leu Val Gln Thr Pro Arg Gly Leu Ser Asp Leu Glu Ile Gly Met Tyr 
        915                 920                 925             


Ala Leu Leu Gly Val Phe Cys Leu Ala Ile Leu Val Phe Leu Ile Asn 
    930                 935                 940                 


Cys Ala Thr Phe Ala Leu Lys Tyr Arg His Lys Gln Val Pro Leu Glu 
945                 950                 955                 960 


Gly Gln Ala Ser Met Thr His Ser His Asp Trp Val Trp Leu Gly Asn 
                965                 970                 975     


Glu Ala Glu Leu Leu Glu Ser Met Gly Asp Ala Pro Pro Pro Gln Asp 
            980                 985                 990         


Glu His Thr Thr Ile Ile Asp Arg  Gly Pro Gly Ala Cys  Glu Glu Ser 
        995                 1000                 1005             


Asn His  Leu Leu Leu Asn Gly  Gly Ser His Lys His  Val Gln Ser 
    1010                 1015                 1020             


Gln Ile  His Arg Ser Ala Asp  Ser Gly Gly Arg Gln  Gly Arg Glu 
    1025                 1030                 1035             


Gln Lys  Gln Asp Pro Leu His  Ser Pro Thr Ser Lys  Arg Lys Lys 
    1040                 1045                 1050             


Val Lys  Phe Thr Thr Phe Thr  Thr Ile Pro Pro Asp  Asp Ser Cys 
    1055                 1060                 1065             


Pro Thr  Val Asn Ser Ile Val  Ser Ser Asn Asp Glu  Asp Ile Lys 
    1070                 1075                 1080             


Trp Val  Cys Gln Asp Val Ala  Val Gly Ala Pro Lys  Glu Leu Arg 
    1085                 1090                 1095             


Asn Tyr  Leu Glu Lys Leu Lys  Asp Lys Ala 
    1100                 1105             


<210> 7
<211> 1099
<212> PRT
<213> Homo sapiens

<400> 7
Met Cys Pro Ser Glu Met Gly Thr Leu Trp His His Trp Ser Pro Val 
1               5                   10                  15      


Leu Ile Ser Leu Ala Ala Leu Phe Ser Lys Val Thr Glu Gly Arg Gly 
            20                  25                  30          


Ile Leu Glu Ser Ile Gln Arg Phe Ser Leu Leu Pro Thr Tyr Leu Pro 
        35                  40                  45              


Val Thr Tyr His Ile Asn Asn Ala Asp Val Ser Phe Phe Leu Lys Glu 
    50                  55                  60                  


Ala Asn Gln Asp Ile Met Arg Asn Ser Ser Leu Gln Ser Arg Val Glu 
65                  70                  75                  80  


Ser Phe Leu Ile Tyr Lys Ser Arg Arg Leu Pro Val Leu Asn Ala Ser 
                85                  90                  95      


Tyr Gly Pro Phe Ser Ile Glu Gln Val Val Pro Gln Asp Leu Met Leu 
            100                 105                 110         


Pro Ser Asn Pro Phe Gly Phe Thr Asn Lys Phe Ser Leu Asn Trp Lys 
        115                 120                 125             


Leu Lys Ala His Ile Leu Arg Asp Lys Val Tyr Leu Ser Arg Pro Lys 
    130                 135                 140                 


Val Gln Val Leu Phe His Ile Met Gly Arg Asp Trp Asp Asp Arg Ser 
145                 150                 155                 160 


Ala Gly Glu Lys Leu Pro Cys Leu Arg Val Phe Ala Phe Arg Glu Thr 
                165                 170                 175     


Arg Glu Val Arg Gly Ser Cys Arg Leu Gln Gly Asp Leu Gly Leu Cys 
            180                 185                 190         


Val Ala Glu Leu Glu Leu Leu Ser Ser Trp Phe Ser Pro Pro Thr Val 
        195                 200                 205             


Val Ala Gly Arg Arg Lys Ser Val Asp Gln Pro Glu Gly Thr Pro Val 
    210                 215                 220                 


Glu Leu Tyr Tyr Thr Val His Pro Gly Gly Glu Arg Gly Asp Cys Val 
225                 230                 235                 240 


Arg Glu Asp Ala Arg Arg Ser Asn Gly Ile Arg Thr Gly His Ser Asp 
                245                 250                 255     


Ile Asp Glu Ser Gly Pro Pro Leu Gln Arg Ile Gly Ser Ile Phe Leu 
            260                 265                 270         


Tyr Gln Thr His Arg Lys Pro Ser Leu Arg Glu Leu Arg Leu Asp Asn 
        275                 280                 285             


Ser Val Ala Ile His Tyr Ile Pro Lys Thr Val Arg Lys Gly Asp Val 
    290                 295                 300                 


Leu Thr Phe Pro Val Ser Ile Ser Arg Asn Ser Thr Glu Asp Arg Phe 
305                 310                 315                 320 


Thr Leu Arg Ala Lys Val Lys Lys Gly Val Asn Ile Ile Gly Val Arg 
                325                 330                 335     


Ala Ser Ser Pro Ser Ile Trp Asp Val Lys Glu Arg Thr Asp Tyr Thr 
            340                 345                 350         


Gly Lys Tyr Ala Pro Ala Val Ile Val Cys Gln Lys Lys Ala Ala Gly 
        355                 360                 365             


Ser Glu Asn Ser Ala Asp Gly Ala Ser Tyr Glu Val Met Gln Ile Asp 
    370                 375                 380                 


Val Glu Val Glu Glu Pro Gly Asp Leu Pro Ala Thr Gln Leu Val Thr 
385                 390                 395                 400 


Trp Gln Val Glu Tyr Pro Gly Glu Ile Thr Ser Asp Leu Gly Val Ser 
                405                 410                 415     


Lys Ile Tyr Val Ser Pro Lys Asp Leu Ile Gly Val Val Pro Leu Ala 
            420                 425                 430         


Met Glu Ala Glu Ile Leu Asn Thr Ala Ile Leu Thr Gly Lys Thr Val 
        435                 440                 445             


Ala Val Pro Val Lys Val Val Ser Val Glu Asp Asp Gly Thr Val Thr 
    450                 455                 460                 


Glu Leu Leu Glu Ser Val Glu Cys Arg Ser Ser Asp Glu Asp Val Ile 
465                 470                 475                 480 


Lys Val Ser Asp Arg Cys Asp Tyr Val Phe Val Asn Gly Lys Glu Met 
                485                 490                 495     


Lys Gly Lys Val Asn Val Val Val Asn Phe Thr Tyr Gln His Leu Ser 
            500                 505                 510         


Ser Pro Leu Glu Met Thr Val Trp Val Pro Arg Leu Pro Leu Gln Ile 
        515                 520                 525             


Glu Val Ser Asp Thr Glu Leu Asn Gln Ile Lys Gly Trp Arg Val Pro 
    530                 535                 540                 


Ile Val Ser Ser Arg Arg Pro Ala Gly Asp Ser Glu Glu Glu Glu Asp 
545                 550                 555                 560 


Asp Glu Arg Arg Gly Arg Gly Cys Thr Leu Gln Tyr Gln His Ala Met 
                565                 570                 575     


Val Arg Val Leu Thr Gln Phe Val Ala Glu Ala Ala Gly Pro Gly Gly 
            580                 585                 590         


His Leu Ala His Leu Leu Gly Ser Asp Trp Gln Val Asp Ile Thr Glu 
        595                 600                 605             


Leu Ile Asn Asp Phe Met Gln Val Glu Glu Pro Arg Ile Ala Lys Leu 
    610                 615                 620                 


Gln Gly Gly Gln Ile Leu Met Gly Gln Glu Leu Gly Met Thr Thr Ile 
625                 630                 635                 640 


Gln Ile Leu Ser Pro Leu Ser Asp Thr Ile Leu Ala Glu Lys Thr Ile 
                645                 650                 655     


Thr Val Leu Asp Glu Lys Val Thr Ile Thr Asp Leu Gly Val Gln Leu 
            660                 665                 670         


Val Thr Gly Leu Ser Leu Ser Leu Gln Leu Ser Pro Gly Ser Asn Arg 
        675                 680                 685             


Ala Ile Phe Ala Thr Ala Val Ala Gln Glu Leu Leu Gln Arg Pro Lys 
    690                 695                 700                 


Gln Glu Ala Ala Ile Ser Cys Trp Val Gln Phe Ser Asp Gly Ser Val 
705                 710                 715                 720 


Thr Pro Leu Asp Ile Tyr Asp Gly Lys Asp Phe Ser Leu Met Ala Thr 
                725                 730                 735     


Ser Leu Asp Glu Lys Val Val Ser Ile His Gln Asp Pro Lys Phe Lys 
            740                 745                 750         


Trp Pro Ile Ile Ala Ala Glu Thr Glu Gly Gln Gly Thr Leu Val Lys 
        755                 760                 765             


Val Glu Met Val Ile Ser Glu Ser Cys Gln Lys Ser Lys Arg Lys Ser 
    770                 775                 780                 


Val Leu Ala Val Gly Thr Ala Asn Ile Lys Val Lys Phe Gly Gln Asn 
785                 790                 795                 800 


Asp Ala Asn Pro Asn Thr Ser Asp Ser Arg His Thr Gly Ala Gly Val 
                805                 810                 815     


His Met Glu Asn Asn Val Ser Asp Arg Arg Pro Lys Lys Pro Ser Gln 
            820                 825                 830         


Glu Trp Gly Ser Gln Glu Gly Gln Tyr Tyr Gly Ser Ser Ser Met Gly 
        835                 840                 845             


Leu Met Glu Gly Arg Gly Thr Thr Thr Asp Arg Ser Ile Leu Gln Lys 
    850                 855                 860                 


Lys Lys Gly Gln Glu Ser Leu Leu Asp Asp Asn Ser His Leu Gln Thr 
865                 870                 875                 880 


Ile Pro Ser Asp Leu Thr Ser Phe Pro Ala Gln Val Asp Leu Pro Arg 
                885                 890                 895     


Ser Asn Gly Glu Met Asp Gly Asn Asp Leu Met Gln Ala Ser Lys Gly 
            900                 905                 910         


Leu Ser Asp Leu Glu Ile Gly Met Tyr Ala Leu Leu Gly Val Phe Cys 
        915                 920                 925             


Leu Ala Ile Leu Val Phe Leu Ile Asn Cys Val Thr Phe Ala Leu Lys 
    930                 935                 940                 


Tyr Arg His Lys Gln Val Pro Phe Glu Glu Gln Glu Gly Met Ser His 
945                 950                 955                 960 


Ser His Asp Trp Val Gly Leu Ser Asn Arg Thr Glu Leu Leu Glu Asn 
                965                 970                 975     


His Ile Asn Phe Ala Ser Ser Gln Asp Glu Gln Ile Thr Ala Ile Asp 
            980                 985                 990         


Arg Gly Met Asp Phe Glu Glu Ser  Lys Tyr Leu Leu Ser  Thr Asn Ser 
        995                 1000                 1005             


Gln Lys  Ser Ile Asn Gly Gln  Leu Phe Lys Pro Leu  Gly Pro Ile 
    1010                 1015                 1020             


Ile Ile  Asp Gly Lys Asp Gln  Lys Ser Glu Pro Pro  Thr Ser Pro 
    1025                 1030                 1035             


Thr Ser  Lys Arg Lys Arg Val  Lys Phe Thr Thr Phe  Thr Ala Val 
    1040                 1045                 1050             


Ser Ser  Asp Asp Glu Tyr Pro  Thr Arg Asn Ser Ile  Val Met Ser 
    1055                 1060                 1065             


Ser Glu  Asp Asp Ile Lys Trp  Val Cys Gln Asp Leu  Asp Pro Gly 
    1070                 1075                 1080             


Asp Cys  Lys Glu Leu His Asn  Tyr Met Glu Arg Leu  His Glu Asn 
    1085                 1090                 1095             


Val 
    


<210> 8
<211> 1074
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Pro Gly Met Ser Gly Arg Gly Gly Ala Ala Leu Leu Cys Leu 
1               5                   10                  15      


Ser Ala Leu Leu Ala His Ala Ser Gly Arg Ser His Pro Ala Ser Pro 
            20                  25                  30          


Ser Pro Pro Gly Pro Gln Ala Ser Pro Val Leu Pro Val Ser Tyr Arg 
        35                  40                  45              


Leu Ser His Thr Arg Leu Ala Phe Phe Leu Arg Glu Ala Arg Pro Pro 
    50                  55                  60                  


Ser Pro Ala Val Ala Asn Ser Ser Leu Gln Arg Ser Glu Pro Phe Val 
65                  70                  75                  80  


Val Phe Gln Thr Lys Glu Leu Pro Val Leu Asn Val Ser Leu Gly Pro 
                85                  90                  95      


Phe Ser Thr Ser Gln Val Val Ala Arg Glu Leu Leu Gln Pro Ser Ser 
            100                 105                 110         


Thr Leu Asp Ile Pro Glu Arg Leu Thr Val Asn Trp Lys Val Arg Ala 
        115                 120                 125             


Phe Ile Val Arg Ser His Val Pro Ala Ser Gln Pro Val Val Gln Val 
    130                 135                 140                 


Leu Phe Tyr Val Ala Gly Arg Asp Trp Asp Asp Phe Gly Val Thr Glu 
145                 150                 155                 160 


Arg Leu Pro Cys Val Arg Leu His Ala Phe Arg Asp Ala Arg Glu Val 
                165                 170                 175     


Lys Ser Ser Cys Arg Leu Ser Gly Gly Leu Ala Thr Cys Leu Val Arg 
            180                 185                 190         


Ala Glu Leu Pro Leu Ala Trp Phe Gly Pro Pro Ala Pro Ala Ala Pro 
        195                 200                 205             


Pro Thr Ala Arg Arg Lys Ser Pro Asp Gly Leu Glu Pro Glu Ala Thr 
    210                 215                 220                 


Gly Glu Ser Gln Gln Ala Glu Leu Tyr Tyr Thr Leu His Ala Pro Asp 
225                 230                 235                 240 


Ala Ser Gly Gly Cys Gly Gly Ser Arg Arg Gly Ala Gly Pro Gly Val 
                245                 250                 255     


Gly Ala Arg Ala Glu Ser Pro Thr Gln His Pro Leu Leu Arg Ile Gly 
            260                 265                 270         


Ser Ile Ser Leu Phe Arg Pro Pro Pro Arg Arg Thr Leu Gln Glu His 
        275                 280                 285             


Arg Leu Asp Ser Asn Leu Met Ile Arg Leu Pro Asp Arg Pro Leu Lys 
    290                 295                 300                 


Pro Gly Glu Val Leu Ser Ile Leu Leu Tyr Leu Ala Pro Asn Ser Ser 
305                 310                 315                 320 


Ser Pro Ser Ser Pro Ser Val Glu His Phe Thr Leu Arg Val Lys Ala 
                325                 330                 335     


Lys Lys Gly Val Thr Leu Leu Gly Thr Lys Ser Arg Ser Gly Gln Trp 
            340                 345                 350         


His Val Thr Ser Glu Leu Leu Thr Gly Ala Lys His Ser Thr Ala Thr 
        355                 360                 365             


Val Asp Val Ala Trp Ala Gln Ser Thr Pro Leu Pro Pro Arg Glu Gly 
    370                 375                 380                 


Gln Gly Pro Leu Glu Ile Leu Gln Leu Asp Phe Glu Met Glu Asn Phe 
385                 390                 395                 400 


Thr Ser Gln Ser Val Lys Arg Arg Ile Met Trp His Ile Asp Tyr Arg 
                405                 410                 415     


Gly His Gly Ala Leu Pro Asp Leu Glu Arg Ala Val Thr Glu Leu Thr 
            420                 425                 430         


Val Ile Gln Arg Asp Val Gln Ala Ile Leu Pro Leu Ala Met Asp Thr 
        435                 440                 445             


Glu Ile Ile Asn Thr Ala Ile Leu Thr Gly Arg Thr Val Ala Ile Pro 
    450                 455                 460                 


Val Lys Val Ile Ala Ile Glu Val Asn Gly Leu Val Leu Asp Ile Ser 
465                 470                 475                 480 


Ala Leu Val Glu Cys Glu Ser Asp Asn Glu Asp Ile Ile Lys Val Ser 
                485                 490                 495     


Ser Ser Cys Asp Tyr Val Phe Val Ser Gly Lys Glu Ser Arg Gly Ser 
            500                 505                 510         


Met Asn Ala Arg Val Thr Phe Arg Tyr Asp Val Leu Asn Ala Pro Leu 
        515                 520                 525             


Glu Met Thr Val Trp Val Pro Lys Leu Pro Leu His Ile Glu Leu Ser 
    530                 535                 540                 


Asp Ala Arg Leu Ser Gln Val Lys Gly Trp Arg Val Pro Ile Leu Pro 
545                 550                 555                 560 


Asp Arg Arg Ser Val Arg Glu Ser Glu Asp Glu Asp Glu Glu Glu Glu 
                565                 570                 575     


Glu Arg Arg Gln Ser Ala Ser Arg Gly Cys Thr Leu Gln Tyr Gln His 
            580                 585                 590         


Ala Thr Leu Gln Val Phe Thr Gln Phe His Thr Thr Ser Ser Glu Gly 
        595                 600                 605             


Thr Asp Gln Val Val Thr Met Leu Gly Pro Asp Trp Leu Val Glu Val 
    610                 615                 620                 


Thr Asp Leu Val Ser Asp Phe Met Arg Val Gly Asp Pro Arg Val Ala 
625                 630                 635                 640 


His Met Val Asp Ser Ser Thr Leu Ala Gly Leu Glu Pro Gly Thr Thr 
                645                 650                 655     


Pro Phe Lys Val Val Ser Pro Leu Thr Glu Ala Val Leu Gly Glu Thr 
            660                 665                 670         


Leu Leu Thr Val Thr Glu Glu Lys Val Ser Ile Thr Gln Leu Gln Ala 
        675                 680                 685             


Gln Val Val Ala Ser Leu Ala Leu Ser Leu Arg Pro Ser Pro Gly Ser 
    690                 695                 700                 


Ser His Thr Ile Leu Ala Thr Thr Ala Ala Gln Gln Thr Leu Ser Phe 
705                 710                 715                 720 


Leu Lys Gln Glu Ala Leu Leu Ser Leu Trp Leu Ser Tyr Ser Asp Gly 
                725                 730                 735     


Thr Thr Ala Pro Leu Ser Leu Tyr Ser Pro Arg Asp Tyr Gly Leu Leu 
            740                 745                 750         


Val Ser Ser Leu Asp Glu His Val Ala Thr Val Thr Gln Asp Arg Ala 
        755                 760                 765             


Phe Pro Leu Val Val Ala Glu Ala Glu Gly Ser Gly Glu Leu Leu Arg 
    770                 775                 780                 


Ala Glu Leu Thr Ile Ala Glu Ser Cys Gln Lys Thr Lys Arg Lys Ser 
785                 790                 795                 800 


Val Leu Ala Thr Thr Pro Val Gly Leu Arg Val His Phe Gly Arg Asp 
                805                 810                 815     


Glu Glu Asp Pro Thr Tyr Asp Tyr Pro Gly Pro Ser Gln Pro Gly Pro 
            820                 825                 830         


Gly Gly Gly Glu Asp Glu Ala Arg Gly Ala Gly Pro Pro Gly Ser Ala 
        835                 840                 845             


Leu Pro Ala Pro Glu Ala Pro Gly Pro Gly Thr Ala Ser Pro Val Val 
    850                 855                 860                 


Pro Pro Thr Glu Asp Phe Leu Pro Leu Pro Thr Gly Phe Leu Gln Val 
865                 870                 875                 880 


Pro Arg Gly Leu Thr Asp Leu Glu Ile Gly Met Tyr Ala Leu Leu Gly 
                885                 890                 895     


Val Phe Cys Leu Ala Ile Leu Val Phe Leu Ile Asn Cys Ile Val Phe 
            900                 905                 910         


Val Leu Arg Tyr Arg His Lys Arg Ile Pro Pro Glu Gly Gln Thr Ser 
        915                 920                 925             


Met Asp His Ser His His Trp Val Phe Leu Gly Asn Gly Gln Pro Leu 
    930                 935                 940                 


Arg Val Gln Gly Glu Leu Ser Pro Pro Ala Gly Asn Pro Leu Glu Thr 
945                 950                 955                 960 


Val Pro Ala Phe Cys His Gly Asp His His Ser Ser Gly Ser Ser Gln 
                965                 970                 975     


Thr Ser Val Gln Ser Gln Val His Gly Arg Gly Asp Gly Ser Ser Gly 
            980                 985                 990         


Gly Ser Ala Arg Asp Gln Ala Glu  Asp Pro Ala Ser Ser  Pro Thr Ser 
        995                 1000                 1005             


Lys Arg  Lys Arg Val Lys Phe  Thr Thr Phe Thr Thr  Leu Pro Ser 
    1010                 1015                 1020             


Glu Glu  Leu Ala Tyr Asp Ser  Val Pro Ala Gly Glu  Glu Asp Glu 
    1025                 1030                 1035             


Glu Glu  Glu Glu Asp Leu Gly  Trp Gly Cys Pro Asp  Val Ala Gly 
    1040                 1045                 1050             


Pro Thr  Arg Pro Thr Ala Pro  Pro Asp Leu His Asn  Tyr Met Arg 
    1055                 1060                 1065             


Arg Ile  Lys Glu Ile Ala 
    1070                 


<210> 9
<211> 134
<212> PRT
<213> Homo sapiens

<400> 9
Met Thr Glu Glu Pro Ile Lys Glu Ile Leu Gly Ala Pro Lys Ala His 
1               5                   10                  15      


Met Ala Ala Thr Met Glu Lys Ser Pro Lys Ser Glu Val Val Ile Thr 
            20                  25                  30          


Thr Val Pro Leu Val Ser Glu Ile Gln Leu Met Ala Ala Thr Gly Gly 
        35                  40                  45              


Thr Glu Leu Ser Cys Tyr Arg Cys Ile Ile Pro Phe Ala Val Val Val 
    50                  55                  60                  


Phe Ile Ala Gly Ile Val Val Thr Ala Val Ala Tyr Ser Phe Asn Ser 
65                  70                  75                  80  


His Gly Ser Ile Ile Ser Ile Phe Gly Leu Val Val Leu Ser Ser Gly 
                85                  90                  95      


Leu Phe Leu Leu Ala Ser Ser Ala Leu Cys Trp Lys Val Arg Gln Arg 
            100                 105                 110         


Ser Lys Lys Ala Lys Arg Arg Glu Ser Gln Thr Ala Leu Val Ala Asn 
        115                 120                 125             


Gln Arg Ser Leu Phe Ala 
    130                 


<210> 10
<211> 281
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


