                         SEQUENCE LISTING

<110>  Ͼѱ¹ҽƼ޹˾
 
<120>  CD19ȫԴ弰Ӧ

<130>  P10439-PCT

<160>  22    

<170>  PatentIn version 3.3

<210>  1
<211>  765
<212>  DNA
<213>  Artificial

<220>
<223>  #62 scFv

<400>  1
cagtctgtcg tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc     60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcaa    120

cttccaggaa cagcccccaa actcctcatc tatgagaaca ccaatcggcc ctcaggggtc    180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc    240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttgg    300

agggtgttcg gcggagggac caagctgacc gtcctaggtt ctagaggtgg tggtggtagc    360

ggcggcggcg gctctggtgg tggtggatcc ctcgagatgg ccgaagtgca gctggtgcag    420

tctggggcag aggtgaaaaa gcccggggag tctctgaaga tctcctgtaa ggggtctgga    480

tacagcttta ccaactcctg gatcggatgg gtgcgccaga tgcccgggaa aggcctggag    540

tggatgggac tcatttaccc tgatgactct gataccagat acagcccatc cttccaaggc    600

caggtcacca tctcagccga cagcgccatc aacaccgcct acctgcagtg gagcagcctg    660

aaggcctcgg acaccgccat gtattactgt gcgcgccagt ctacctacat ctacggtggt    720

tactacgata cctggggtca aggtactctg gtgaccgtct cctca                    765


<210>  2
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  #62 VL

<400>  2
cagtctgtcg tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc     60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcaa    120

cttccaggaa cagcccccaa actcctcatc tatgagaaca ccaatcggcc ctcaggggtc    180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc    240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttgg    300

agggtgttcg gcggagggac caagctgacc gtcctaggt                           339


<210>  3
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  #62 VH

<400>  3
atggccgaag tgcagctggt gcagtctggg gcagaggtga aaaagcccgg ggagtctctg     60

aagatctcct gtaaggggtc tggatacagc tttaccaact cctggatcgg atgggtgcgc    120

cagatgcccg ggaaaggcct ggagtggatg ggactcattt accctgatga ctctgatacc    180

agatacagcc catccttcca aggccaggtc accatctcag ccgacagcgc catcaacacc    240

gcctacctgc agtggagcag cctgaaggcc tcggacaccg ccatgtatta ctgtgcgcgc    300

cagtctacct acatctacgg tggttactac gatacctggg gtcaaggtac tctggtgacc    360

gtctcctca                                                            369


<210>  4
<211>  753
<212>  DNA
<213>  Artificial

<220>
<223>  #78 scFv

<400>  4
caggctgtgc tgactcagcc accctcggtg tctgaagccc ccaggcagag ggtcaccatc     60

tcctgttctg gaagcagctc caacatcgga aataatgctg taagctggta ccagcagctc    120

ccaggaaagg ctcccaaact cctcatctat tatgatgatc tgctcccctc aggggtctct    180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag    240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggttgggtg    300

ttcggcggag ggaccaaggt caccgtccta ggttctagag gtggtggtgg tagcggcggc    360

ggcggctctg gtggtggtgg atccctcgag gaggtgcagc tggtgcagtc tggagcagag    420

gtgaaaaagc ccggggagtc tctgaagatc tcctgtaagg gttctggata cagctttacc    480

agctactgga tcggctgggt gcgccagatg cccgggaaag gcctggagtg gatggggatc    540

atctatcctg gtgactctga taccagatac agcccgtcct tccaaggcca ggtcaccatc    600

tcagccgaca agtccatcag caccgcctac ctgcagtgga gcagcctgaa ggcctcggac    660

accgccatgt attactgtgc gcgcctgtct tactcttggt cttcttggta ctgggatttc    720

tggggtcaag gtactctggt gaccgtctcc tca                                 753


<210>  5
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>   #78 VL

<400>  5
caggctgtgc tgactcagcc accctcggtg tctgaagccc ccaggcagag ggtcaccatc     60

tcctgttctg gaagcagctc caacatcgga aataatgctg taagctggta ccagcagctc    120

ccaggaaagg ctcccaaact cctcatctat tatgatgatc tgctcccctc aggggtctct    180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag    240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggttgggtg    300

ttcggcggag ggaccaaggt caccgtccta ggt                                 333


<210>  6
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>   #78 VH

<400>  6
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc     60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg    120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac    180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac    240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gcgcctgtct    300

tactcttggt cttcttggta ctgggatttc tggggtcaag gtactctggt gaccgtctcc    360

tca                                                                  363


<210>  7
<211>  255
<212>  PRT
<213>  Artificial

<220>
<223>   #62 scFv

<400>  7

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Trp Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
    130                 135                 140                 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
145                 150                 155                 160 


Tyr Ser Phe Thr Asn Ser Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Met Gly Leu Ile Tyr Pro Asp Asp Ser Asp Thr 
            180                 185                 190         


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Ser 
        195                 200                 205             


Ala Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
    210                 215                 220                 


Thr Ala Met Tyr Tyr Cys Ala Arg Gln Ser Thr Tyr Ile Tyr Gly Gly 
225                 230                 235                 240 


Tyr Tyr Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255 


<210>  8
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  #62 VL

<400>  8

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Trp Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly 
    


<210>  9
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  #62 VH

<400>  9

Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
1               5                   10                  15      


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
            20                  25                  30          


Asn Ser Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Leu Ile Tyr Pro Asp Asp Ser Asp Thr Arg Tyr Ser Pro 
    50                  55                  60                  


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Ser Ala Ile Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gln Ser Thr Tyr Ile Tyr Gly Gly Tyr Tyr Asp Thr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  10
<211>  251
<212>  PRT
<213>  Artificial

<220>
<223>   #78 scFv

<400>  10

Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Ser Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Ser 
            100                 105                 110         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Leu Glu Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
    130                 135                 140                 


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
145                 150                 155                 160 


Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro 
            180                 185                 190         


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
        195                 200                 205             


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg Leu Ser Tyr Ser Trp Ser Ser Trp Tyr Trp Asp Phe 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  11
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>   #78 VL

<400>  11

Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Ser Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110     


<210>  12
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>   #78 VH

<400>  12

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Tyr Ser Trp Ser Ser Trp Tyr Trp Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  13
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  #62 HCDR1

<400>  13

Gly Tyr Ser Phe Thr Asn Ser Trp 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  #62 HCDR2

<400>  14

Ile Tyr Pro Asp Asp Ser Asp Thr 
1               5               


<210>  15
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  #62 HCDR3

<400>  15

Ala Arg Gln Ser Thr Tyr Ile Tyr Gly Gly Tyr Tyr Asp Thr 
1               5                   10                  


<210>  16
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  #62 LCDR1

<400>  16

Ser Ser Asn Ile Gly Ala Gly Tyr Asp 
1               5                   


<210>  17
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  #62 LCDR3

<400>  17

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Trp Arg Val 
1               5                   10          


<210>  18
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  #78 HCDR1

<400>  18

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  #78 HCDR2

<400>  19

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  20
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  #78 HCDR3

<400>  20

Ala Arg Leu Ser Tyr Ser Trp Ser Ser Trp Tyr Trp Asp Phe 
1               5                   10                  


<210>  21
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  #78 LCDR1

<400>  21

Ser Ser Asn Ile Gly Asn Asn Ala 
1               5               


<210>  22
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  #78 LCDR3

<400>  22

Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 
1               5                   10      


