                         SEQUENCE LISTING

<110>  Nanjingjinsirui Science &Technology Biology Corp.
 
<120>  ANTI-CD47/ANTI-PD-L1 MULTIPLE ANTIGEN BINDING PROTEINS AND METHODS OF USE THEREOF

<130>  065782.9US1

<150>  PCT/CN2019/087364
<151>  2019-05-17

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of secretory signal peptide

<400>  1
atgggctggt cctgcatcat cctgttcctg gtggctaccg ccaccggcgt gcactcc          57


<210>  2
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of secretory signal peptide

<400>  2

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  3
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of heavy chain of CD47 mAb

<400>  3
gaggtgcagc tggtgcagtc cggagctgag gtgaagaagc caggatccag cgtgaaggtg       60

agctgcaagg ctagcggcta ctctttcacc caccattgga tccactgggt gaggcaggct      120

cctggacagg gactggagtg gatgggcatg atcgacgctt ccgatagcga gacaagactg      180

tctcagaagt ttaaggaccg cgtgaccatc acagccgata agtctacctc cacagcttac      240

atggagctgt cttccctgag atccgaggac accgccgtgt actattgtgc taggctgggc      300

cggtactatt tcgattattg gggccagggc accacagtga cagtgagctc tgccagcaca      360

aagggccctt ccgtgttccc actggctccc tgctccagaa gcacatctga gtccaccgcc      420

gctctgggct gtctggtgaa ggactacttc cctgagccag tgaccgtgtc ctggaacagc      480

ggcgccctga catctggcgt gcacaccttt ccagctgtgc tgcagtccag cggcctgtac      540

tccctgtctt ccgtggtgac agtgcccagc tcttccctgg gcaccaagac atatacctgc      600

aacgtggacc ataagccttc caataccaag gtggataaga gggtggagag caagtacgga      660

ccaccttgcc caccatgtcc agctcctgag tttgagggag gaccatccgt gttcctgttt      720

cctccaaagc ctaaggacac cctgatgatc agccggacac ctgaggtgac ctgcgtggtg      780

gtggacgtgt ctcaggagga tccagaggtg cagttcaact ggtacgtgga tggcgtggag      840

gtgcacaatg ctaagaccaa gccaagagag gagcagttta attccacata ccgcgtggtg      900

agcgtgctga ccgtgctgca tcaggattgg ctgaacggca aggagtataa gtgcaaggtg      960

tccaataagg gcctgcccag ctctatcgag aagacaatca gcaaggctaa gggacagcct     1020

agggagccac aggtgtacac cctgccccct tctcaggagg agatgacaaa gaaccaggtg     1080

tccctgacct gtctggtgaa gggcttctat ccaagcgaca tcgctgtgga gtgggagtct     1140

aatggccagc ccgagaacaa ttacaagacc acaccacccg tgctggactc tgatggctcc     1200

ttctttctgt attctaggct gacagtggat aagtcccggt ggcaggaggg caacgtgttt     1260

agctgctctg tgatgcacga ggccctgcac aatcattata cccagaagtc cctgagcctg     1320

tctctgggca ag                                                         1332


<210>  4
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of heavy chain of CD47 mAb

<400>  4

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr His His 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asp Ala Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 


<210>  5
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of light chain of CD47 mAb

<400>  5
gagatcgtgc tgacccagtc tccagccaca ctgtctctgt ccccaggaga gagggccacc       60

ctgagctgcc gggcttctga gaacgtgggc acatacatct cctggtatca gcagaagcca      120

ggacaggctc ctaggctgct gatctacggc gctagcaata gatataccgg catccctgct      180

cgcttcagcg gatctggatc cggcacagac tttaccctga caatctccag cctggagcca      240

gaggatttcg ccgtgtacta ttgtggcgag tcctacggcc acctgtatac ctttggcggc      300

ggcacaaagg tggagatcaa gcgaacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  6
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of light chain of CD47 mAb

<400>  6

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          


Ile Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gly Glu Ser Tyr Gly His Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  7
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of E-linker

<400>  7
gaacctaagt ctagcgacaa aactcatacc agccccccta gtcca                       45


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of E-linker

<400>  8

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  9
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of G-linker

<400>  9
ggtggaggcg gtagtggagg cggtggttca ggcggaggcg gatct                       45


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of G-linker

<400>  10

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  11
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of modified human IgG4 Fc (IgG4PE)

<400>  11
gagagcaagt acggaccacc ttgcccacca tgtccagctc ctgagtttga gggaggacca       60

tccgtgttcc tgtttcctcc aaagcctaag gacaccctga tgatcagccg gacacctgag      120

gtgacctgcg tggtggtgga cgtgtctcag gaggatccag aggtgcagtt caactggtac      180

gtggatggcg tggaggtgca caatgctaag accaagccaa gagaggagca gtttaattcc      240

acataccgcg tggtgagcgt gctgaccgtg ctgcatcagg attggctgaa cggcaaggag      300

tataagtgca aggtgtccaa taagggcctg cccagctcta tcgagaagac aatcagcaag      360

gctaagggac agcctaggga gccacaggtg tacaccctgc ccccttctca ggaggagatg      420

acaaagaacc aggtgtccct gacctgtctg gtgaagggct tctatccaag cgacatcgct      480

gtggagtggg agtctaatgg ccagcccgag aacaattaca agaccacacc acccgtgctg      540

gactctgatg gctccttctt tctgtattct aggctgacag tggataagtc ccggtggcag      600

gagggcaacg tgtttagctg ctctgtgatg cacgaggccc tgcacaatca ttatacccag      660

aagtccctga gcctgtctct gggcaag                                          687


<210>  12
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of modified human IgG4 Fc (IgG4PE)

<400>  12

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  13
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of PDL1a sdAb

<400>  13
gaggtgcagc tggtggaatc cggcggaggc ctggtccagc ctggcggctc tctgcggctg       60

tcctgcgccg cttctggcag aaccttcgtg acctacggca tgggctggtt ccggcaggct      120

cctggcaagg gcagagagtt cgtgtccgcc atctcctggt ccggctccat gacctcttac      180

ggcgactctg tgaagggcag attcaccatc agccgggata acgccaagaa cacactgtac      240

ctgcagatga actccctgcg gcctgaggac accgccgtgt actactgcgc cgctgccctg      300

ggcgctgtcg tgtacaccac cagagaaccc tatacctact ggggacaggg caccctggtg      360

accgtgtcct ct                                                          372


<210>  14
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of PDL1a sdAb

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Val Thr Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Ser Gly Ser Met Thr Ser Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Leu Gly Ala Val Val Tyr Thr Thr Arg Glu Pro Tyr Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  15
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of PDL1b sdAb

<400>  15
gaggtgcagc tggtggaatc cggcggaggc ctggtccagc ctggcggctc tctgcggctg       60

tcctgcgccg cttctggcag aaccttcgtg acctacggca tgggctggtt ccggcaggct      120

cctggcaagg gcagagagtt cgtgtccgcc atctcctggt ccggctccag cacctcttac      180

ggcgactctg tgaagggcag attcaccatc agccgggata acgccaagaa cacactgtac      240

ctgcagatga actccctgcg gcctgaggac accgccgtgt actactgcgc cgctgccctg      300

ggcgctgtcg tgtacaccac cagagaaccc tatacctact ggggacaggg caccctggtg      360

accgtgtcct ct                                                          372


<210>  16
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of PDL1b sdAb

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Val Thr Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Ser Gly Ser Ser Thr Ser Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Leu Gly Ala Val Val Tyr Thr Thr Arg Glu Pro Tyr Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  17
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of PDL1c sdAb

<400>  17
gaggtgcagc tggtggaatc cggcggaggc ctggtgcagc ctggcggctc tctgagactg       60

tcctgcgccg cttctggccg gaccttcatc acctacgcca tcggctggtt cagacaggcc      120

cctggcaagg gcagagagtt cgtgtccgcc atctcctggt ccggctctat gaccagctac      180

gccgactctg tgaagggcag attcaccatc tcccgggata acgccaagaa caccctgtac      240

ctgcagatga attccctgag acctgaggac acagctgtgt attactgcgc cgctcaccgg      300

ggcgccatcg ctcccatcgc tcagagcgtg tacaccaact ggggccaggg aaccctggtc      360

accgtgtcca gc                                                          372


<210>  18
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of PDL1c sdAb

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ile Thr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Ser Gly Ser Met Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Gly Ala Ile Ala Pro Ile Ala Gln Ser Val Tyr Thr 
            100                 105                 110         


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD47 HCDR1

<400>  19

Gly Tyr Ser Phe Thr His His Trp Ile His 
1               5                   10  


<210>  20
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD47 HCDR2

<400>  20

Met Ile Asp Ala Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD47 HCDR3

<400>  21

Leu Gly Arg Tyr Tyr Phe Asp Tyr 
1               5               


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD47 LCDR1

<400>  22

Arg Ala Ser Glu Asn Val Gly Thr Tyr Ile Ser 
1               5                   10      


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD47 LCDR2

<400>  23

Gly Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD47 LCDR3

<400>  24

Gly Glu Ser Tyr Gly His Leu Tyr Thr 
1               5                   


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-PD-L1 (a) CDR1

<400>  25

Gly Arg Thr Phe Val Thr Tyr Gly Met Gly 
1               5                   10  


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-PD-L1 (a) CDR2

<400>  26

Ala Ile Ser Trp Ser Gly Ser Met Thr Ser Tyr Gly Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-PD-L1 (a) CDR3

<400>  27

Ala Leu Gly Ala Val Val Tyr Thr Thr Arg Glu Pro Tyr Thr Tyr 
1               5                   10                  15  


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-PD-L1 (b) CDR1

<400>  28

Gly Arg Thr Phe Val Thr Tyr Gly Met Gly 
1               5                   10  


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-PD-L1 (b) CDR2

<400>  29

Ala Ile Ser Trp Ser Gly Ser Ser Thr Ser Tyr Gly Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  30
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-PD-L1 (b) CDR3

<400>  30

Ala Leu Gly Ala Val Val Tyr Thr Thr Arg Glu Pro Tyr Thr Tyr 
1               5                   10                  15  


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-PD-L1 (c) CDR1

<400>  31

Gly Arg Thr Phe Ile Thr Tyr Ala Ile Gly 
1               5                   10  


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-PD-L1 (c) CDR2

<400>  32

Ala Ile Ser Trp Ser Gly Ser Met Thr Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  33
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-PD-L1 (c) CDR3

<400>  33

His Arg Gly Ala Ile Ala Pro Ile Ala Gln Ser Val Tyr Thr Asn 
1               5                   10                  15  


<210>  34
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1

<400>  34

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val 
    210                 215                 220                 


Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile 
225                 230                 235                 240 


Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile 
                245                 250                 255     


Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr 
            260                 265                 270         


<210>  35
<211>  1749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of H1

<400>  35
gaggtgcagc tggtgcagtc cggagctgag gtgaagaagc caggatccag cgtgaaggtg       60

agctgcaagg ctagcggcta ctctttcacc caccattgga tccactgggt gaggcaggct      120

cctggacagg gactggagtg gatgggcatg atcgacgctt ccgatagcga gacaagactg      180

tctcagaagt ttaaggaccg cgtgaccatc acagccgata agtctacctc cacagcttac      240

atggagctgt cttccctgag atccgaggac accgccgtgt actattgtgc taggctgggc      300

cggtactatt tcgattattg gggccagggc accacagtga cagtgagctc tgccagcaca      360

aagggccctt ccgtgttccc actggctccc tgctccagaa gcacatctga gtccaccgcc      420

gctctgggct gtctggtgaa ggactacttc cctgagccag tgaccgtgtc ctggaacagc      480

ggcgccctga catctggcgt gcacaccttt ccagctgtgc tgcagtccag cggcctgtac      540

tccctgtctt ccgtggtgac agtgcccagc tcttccctgg gcaccaagac atatacctgc      600

aacgtggacc ataagccttc caataccaag gtggataaga gggtggagag caagtacgga      660

ccaccttgcc caccatgtcc agctcctgag tttgagggag gaccatccgt gttcctgttt      720

cctccaaagc ctaaggacac cctgatgatc agccggacac ctgaggtgac ctgcgtggtg      780

gtggacgtgt ctcaggagga tccagaggtg cagttcaact ggtacgtgga tggcgtggag      840

gtgcacaatg ctaagaccaa gccaagagag gagcagttta attccacata ccgcgtggtg      900

agcgtgctga ccgtgctgca tcaggattgg ctgaacggca aggagtataa gtgcaaggtg      960

tccaataagg gcctgcccag ctctatcgag aagacaatca gcaaggctaa gggacagcct     1020

agggagccac aggtgtacac cctgccccct tctcaggagg agatgacaaa gaaccaggtg     1080

tccctgacct gtctggtgaa gggcttctat ccaagcgaca tcgctgtgga gtgggagtct     1140

aatggccagc ccgagaacaa ttacaagacc acaccacccg tgctggactc tgatggctcc     1200

ttctttctgt attctaggct gacagtggat aagtcccggt ggcaggaggg caacgtgttt     1260

agctgctctg tgatgcacga ggccctgcac aatcattata cccagaagtc cctgagcctg     1320

tctctgggca aggaacctaa gtctagcgac aaaactcata ccagcccccc tagtccagag     1380

gtgcagctgg tggaatccgg cggaggcctg gtccagcctg gcggctctct gcggctgtcc     1440

tgcgccgctt ctggcagaac cttcgtgacc tacggcatgg gctggttccg gcaggctcct     1500

ggcaagggca gagagttcgt gtccgccatc tcctggtccg gctccatgac ctcttacggc     1560

gactctgtga agggcagatt caccatcagc cgggataacg ccaagaacac actgtacctg     1620

cagatgaact ccctgcggcc tgaggacacc gccgtgtact actgcgccgc tgccctgggc     1680

gctgtcgtgt acaccaccag agaaccctat acctactggg gacagggcac cctggtgacc     1740

gtgtcctct                                                             1749


<210>  36
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of H1

<400>  36

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr His His 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asp Ala Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Glu Pro Lys Ser 
        435                 440                 445             


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Glu Val Gln Leu Val 
    450                 455                 460                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
465                 470                 475                 480 


Cys Ala Ala Ser Gly Arg Thr Phe Val Thr Tyr Gly Met Gly Trp Phe 
                485                 490                 495     


Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val Ser Ala Ile Ser Trp 
            500                 505                 510         


Ser Gly Ser Met Thr Ser Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr 
        515                 520                 525             


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
    530                 535                 540                 


Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Leu Gly 
545                 550                 555                 560 


Ala Val Val Tyr Thr Thr Arg Glu Pro Tyr Thr Tyr Trp Gly Gln Gly 
                565                 570                 575     


Thr Leu Val Thr Val Ser Ser 
            580             


<210>  37
<211>  1749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of H2

<400>  37
gaggtgcagc tggtgcagtc cggagctgag gtgaagaagc caggatccag cgtgaaggtg       60

agctgcaagg ctagcggcta ctctttcacc caccattgga tccactgggt gaggcaggct      120

cctggacagg gactggagtg gatgggcatg atcgacgctt ccgatagcga gacaagactg      180

tctcagaagt ttaaggaccg cgtgaccatc acagccgata agtctacctc cacagcttac      240

atggagctgt cttccctgag atccgaggac accgccgtgt actattgtgc taggctgggc      300

cggtactatt tcgattattg gggccagggc accacagtga cagtgagctc tgccagcaca      360

aagggccctt ccgtgttccc actggctccc tgctccagaa gcacatctga gtccaccgcc      420

gctctgggct gtctggtgaa ggactacttc cctgagccag tgaccgtgtc ctggaacagc      480

ggcgccctga catctggcgt gcacaccttt ccagctgtgc tgcagtccag cggcctgtac      540

tccctgtctt ccgtggtgac agtgcccagc tcttccctgg gcaccaagac atatacctgc      600

aacgtggacc ataagccttc caataccaag gtggataaga gggtggagag caagtacgga      660

ccaccttgcc caccatgtcc agctcctgag tttgagggag gaccatccgt gttcctgttt      720

cctccaaagc ctaaggacac cctgatgatc agccggacac ctgaggtgac ctgcgtggtg      780

gtggacgtgt ctcaggagga tccagaggtg cagttcaact ggtacgtgga tggcgtggag      840

gtgcacaatg ctaagaccaa gccaagagag gagcagttta attccacata ccgcgtggtg      900

agcgtgctga ccgtgctgca tcaggattgg ctgaacggca aggagtataa gtgcaaggtg      960

tccaataagg gcctgcccag ctctatcgag aagacaatca gcaaggctaa gggacagcct     1020

agggagccac aggtgtacac cctgccccct tctcaggagg agatgacaaa gaaccaggtg     1080

tccctgacct gtctggtgaa gggcttctat ccaagcgaca tcgctgtgga gtgggagtct     1140

aatggccagc ccgagaacaa ttacaagacc acaccacccg tgctggactc tgatggctcc     1200

ttctttctgt attctaggct gacagtggat aagtcccggt ggcaggaggg caacgtgttt     1260

agctgctctg tgatgcacga ggccctgcac aatcattata cccagaagtc cctgagcctg     1320

tctctgggca aggaacctaa gtctagcgac aaaactcata ccagcccccc tagtccagag     1380

gtgcagctgg tggaatccgg cggaggcctg gtccagcctg gcggctctct gcggctgtcc     1440

tgcgccgctt ctggcagaac cttcgtgacc tacggcatgg gctggttccg gcaggctcct     1500

ggcaagggca gagagttcgt gtccgccatc tcctggtccg gctccagcac ctcttacggc     1560

gactctgtga agggcagatt caccatcagc cgggataacg ccaagaacac actgtacctg     1620

cagatgaact ccctgcggcc tgaggacacc gccgtgtact actgcgccgc tgccctgggc     1680

gctgtcgtgt acaccaccag agaaccctat acctactggg gacagggcac cctggtgacc     1740

gtgtcctct                                                             1749


<210>  38
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of H2

<400>  38

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr His His 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asp Ala Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Glu Pro Lys Ser 
        435                 440                 445             


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Glu Val Gln Leu Val 
    450                 455                 460                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
465                 470                 475                 480 


Cys Ala Ala Ser Gly Arg Thr Phe Val Thr Tyr Gly Met Gly Trp Phe 
                485                 490                 495     


Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val Ser Ala Ile Ser Trp 
            500                 505                 510         


Ser Gly Ser Ser Thr Ser Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr 
        515                 520                 525             


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
    530                 535                 540                 


Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Leu Gly 
545                 550                 555                 560 


Ala Val Val Tyr Thr Thr Arg Glu Pro Tyr Thr Tyr Trp Gly Gln Gly 
                565                 570                 575     


Thr Leu Val Thr Val Ser Ser 
            580             


<210>  39
<211>  1749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of H3

<400>  39
gaggtgcagc tggtgcagtc cggagctgag gtgaagaagc caggatccag cgtgaaggtg       60

agctgcaagg ctagcggcta ctctttcacc caccattgga tccactgggt gaggcaggct      120

cctggacagg gactggagtg gatgggcatg atcgacgctt ccgatagcga gacaagactg      180

tctcagaagt ttaaggaccg cgtgaccatc acagccgata agtctacctc cacagcttac      240

atggagctgt cttccctgag atccgaggac accgccgtgt actattgtgc taggctgggc      300

cggtactatt tcgattattg gggccagggc accacagtga cagtgagctc tgccagcaca      360

aagggccctt ccgtgttccc actggctccc tgctccagaa gcacatctga gtccaccgcc      420

gctctgggct gtctggtgaa ggactacttc cctgagccag tgaccgtgtc ctggaacagc      480

ggcgccctga catctggcgt gcacaccttt ccagctgtgc tgcagtccag cggcctgtac      540

tccctgtctt ccgtggtgac agtgcccagc tcttccctgg gcaccaagac atatacctgc      600

aacgtggacc ataagccttc caataccaag gtggataaga gggtggagag caagtacgga      660

ccaccttgcc caccatgtcc agctcctgag tttgagggag gaccatccgt gttcctgttt      720

cctccaaagc ctaaggacac cctgatgatc agccggacac ctgaggtgac ctgcgtggtg      780

gtggacgtgt ctcaggagga tccagaggtg cagttcaact ggtacgtgga tggcgtggag      840

gtgcacaatg ctaagaccaa gccaagagag gagcagttta attccacata ccgcgtggtg      900

agcgtgctga ccgtgctgca tcaggattgg ctgaacggca aggagtataa gtgcaaggtg      960

tccaataagg gcctgcccag ctctatcgag aagacaatca gcaaggctaa gggacagcct     1020

agggagccac aggtgtacac cctgccccct tctcaggagg agatgacaaa gaaccaggtg     1080

tccctgacct gtctggtgaa gggcttctat ccaagcgaca tcgctgtgga gtgggagtct     1140

aatggccagc ccgagaacaa ttacaagacc acaccacccg tgctggactc tgatggctcc     1200

ttctttctgt attctaggct gacagtggat aagtcccggt ggcaggaggg caacgtgttt     1260

agctgctctg tgatgcacga ggccctgcac aatcattata cccagaagtc cctgagcctg     1320

tctctgggca aggaacctaa gtctagcgac aaaactcata ccagcccccc tagtccagag     1380

gtgcagctgg tggaatccgg cggaggcctg gtgcagcctg gcggctctct gagactgtcc     1440

tgcgccgctt ctggccggac cttcatcacc tacgccatcg gctggttcag acaggcccct     1500

ggcaagggca gagagttcgt gtccgccatc tcctggtccg gctctatgac cagctacgcc     1560

gactctgtga agggcagatt caccatctcc cgggataacg ccaagaacac cctgtacctg     1620

cagatgaatt ccctgagacc tgaggacaca gctgtgtatt actgcgccgc tcaccggggc     1680

gccatcgctc ccatcgctca gagcgtgtac accaactggg gccagggaac cctggtcacc     1740

gtgtccagc                                                             1749


<210>  40
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of H3

<400>  40

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr His His 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asp Ala Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Glu Pro Lys Ser 
        435                 440                 445             


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Glu Val Gln Leu Val 
    450                 455                 460                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
465                 470                 475                 480 


Cys Ala Ala Ser Gly Arg Thr Phe Ile Thr Tyr Ala Ile Gly Trp Phe 
                485                 490                 495     


Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val Ser Ala Ile Ser Trp 
            500                 505                 510         


Ser Gly Ser Met Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
        515                 520                 525             


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
    530                 535                 540                 


Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Arg Gly 
545                 550                 555                 560 


Ala Ile Ala Pro Ile Ala Gln Ser Val Tyr Thr Asn Trp Gly Gln Gly 
                565                 570                 575     


Thr Leu Val Thr Val Ser Ser 
            580             


<210>  41
<211>  1749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of H4

<400>  41
gaggtgcagc tggtggaatc cggcggaggc ctggtccagc ctggcggctc tctgcggctg       60

tcctgcgccg cttctggcag aaccttcgtg acctacggca tgggctggtt ccggcaggct      120

cctggcaagg gcagagagtt cgtgtccgcc atctcctggt ccggctccat gacctcttac      180

ggcgactctg tgaagggcag attcaccatc agccgggata acgccaagaa cacactgtac      240

ctgcagatga actccctgcg gcctgaggac accgccgtgt actactgcgc cgctgccctg      300

ggcgctgtcg tgtacaccac cagagaaccc tatacctact ggggacaggg caccctggtg      360

accgtgtcct ctgaacctaa gtctagcgac aaaactcata ccagcccccc tagtccagag      420

gtgcagctgg tgcagtccgg agctgaggtg aagaagccag gatccagcgt gaaggtgagc      480

tgcaaggcta gcggctactc tttcacccac cattggatcc actgggtgag gcaggctcct      540

ggacagggac tggagtggat gggcatgatc gacgcttccg atagcgagac aagactgtct      600

cagaagttta aggaccgcgt gaccatcaca gccgataagt ctacctccac agcttacatg      660

gagctgtctt ccctgagatc cgaggacacc gccgtgtact attgtgctag gctgggccgg      720

tactatttcg attattgggg ccagggcacc acagtgacag tgagctctgc cagcacaaag      780

ggcccttccg tgttcccact ggctccctgc tccagaagca catctgagtc caccgccgct      840

ctgggctgtc tggtgaagga ctacttccct gagccagtga ccgtgtcctg gaacagcggc      900

gccctgacat ctggcgtgca cacctttcca gctgtgctgc agtccagcgg cctgtactcc      960

ctgtcttccg tggtgacagt gcccagctct tccctgggca ccaagacata tacctgcaac     1020

gtggaccata agccttccaa taccaaggtg gataagaggg tggagagcaa gtacggacca     1080

ccttgcccac catgtccagc tcctgagttt gagggaggac catccgtgtt cctgtttcct     1140

ccaaagccta aggacaccct gatgatcagc cggacacctg aggtgacctg cgtggtggtg     1200

gacgtgtctc aggaggatcc agaggtgcag ttcaactggt acgtggatgg cgtggaggtg     1260

cacaatgcta agaccaagcc aagagaggag cagtttaatt ccacataccg cgtggtgagc     1320

gtgctgaccg tgctgcatca ggattggctg aacggcaagg agtataagtg caaggtgtcc     1380

aataagggcc tgcccagctc tatcgagaag acaatcagca aggctaaggg acagcctagg     1440

gagccacagg tgtacaccct gcccccttct caggaggaga tgacaaagaa ccaggtgtcc     1500

ctgacctgtc tggtgaaggg cttctatcca agcgacatcg ctgtggagtg ggagtctaat     1560

ggccagcccg agaacaatta caagaccaca ccacccgtgc tggactctga tggctccttc     1620

tttctgtatt ctaggctgac agtggataag tcccggtggc aggagggcaa cgtgtttagc     1680

tgctctgtga tgcacgaggc cctgcacaat cattataccc agaagtccct gagcctgtct     1740

ctgggcaag                                                             1749


<210>  42
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of H4

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Val Thr Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Ser Gly Ser Met Thr Ser Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Leu Gly Ala Val Val Tyr Thr Thr Arg Glu Pro Tyr Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Glu Val Gln Leu Val 
    130                 135                 140                 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
145                 150                 155                 160 


Cys Lys Ala Ser Gly Tyr Ser Phe Thr His His Trp Ile His Trp Val 
                165                 170                 175     


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Met Ile Asp Ala 
            180                 185                 190         


Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys Phe Lys Asp Arg Val Thr 
        195                 200                 205             


Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
    210                 215                 220                 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Gly Arg 
225                 230                 235                 240 


Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
            260                 265                 270         


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
        275                 280                 285             


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
    290                 295                 300                 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
305                 310                 315                 320 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
                325                 330                 335     


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
            340                 345                 350         


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
        355                 360                 365             


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    370                 375                 380                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
385                 390                 395                 400 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
                405                 410                 415     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
            420                 425                 430         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        435                 440                 445             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
    450                 455                 460                 


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
465                 470                 475                 480 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
                485                 490                 495     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            500                 505                 510         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        515                 520                 525             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    530                 535                 540                 


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
545                 550                 555                 560 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                565                 570                 575     


Leu Ser Leu Ser Leu Gly Lys 
            580             


<210>  43
<211>  1749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of H5

<400>  43
gaggtgcagc tggtggaatc cggcggaggc ctggtccagc ctggcggctc tctgcggctg       60

tcctgcgccg cttctggcag aaccttcgtg acctacggca tgggctggtt ccggcaggct      120

cctggcaagg gcagagagtt cgtgtccgcc atctcctggt ccggctccag cacctcttac      180

ggcgactctg tgaagggcag attcaccatc agccgggata acgccaagaa cacactgtac      240

ctgcagatga actccctgcg gcctgaggac accgccgtgt actactgcgc cgctgccctg      300

ggcgctgtcg tgtacaccac cagagaaccc tatacctact ggggacaggg caccctggtg      360

accgtgtcct ctgaacctaa gtctagcgac aaaactcata ccagcccccc tagtccagag      420

gtgcagctgg tgcagtccgg agctgaggtg aagaagccag gatccagcgt gaaggtgagc      480

tgcaaggcta gcggctactc tttcacccac cattggatcc actgggtgag gcaggctcct      540

ggacagggac tggagtggat gggcatgatc gacgcttccg atagcgagac aagactgtct      600

cagaagttta aggaccgcgt gaccatcaca gccgataagt ctacctccac agcttacatg      660

gagctgtctt ccctgagatc cgaggacacc gccgtgtact attgtgctag gctgggccgg      720

tactatttcg attattgggg ccagggcacc acagtgacag tgagctctgc cagcacaaag      780

ggcccttccg tgttcccact ggctccctgc tccagaagca catctgagtc caccgccgct      840

ctgggctgtc tggtgaagga ctacttccct gagccagtga ccgtgtcctg gaacagcggc      900

gccctgacat ctggcgtgca cacctttcca gctgtgctgc agtccagcgg cctgtactcc      960

ctgtcttccg tggtgacagt gcccagctct tccctgggca ccaagacata tacctgcaac     1020

gtggaccata agccttccaa taccaaggtg gataagaggg tggagagcaa gtacggacca     1080

ccttgcccac catgtccagc tcctgagttt gagggaggac catccgtgtt cctgtttcct     1140

ccaaagccta aggacaccct gatgatcagc cggacacctg aggtgacctg cgtggtggtg     1200

gacgtgtctc aggaggatcc agaggtgcag ttcaactggt acgtggatgg cgtggaggtg     1260

cacaatgcta agaccaagcc aagagaggag cagtttaatt ccacataccg cgtggtgagc     1320

gtgctgaccg tgctgcatca ggattggctg aacggcaagg agtataagtg caaggtgtcc     1380

aataagggcc tgcccagctc tatcgagaag acaatcagca aggctaaggg acagcctagg     1440

gagccacagg tgtacaccct gcccccttct caggaggaga tgacaaagaa ccaggtgtcc     1500

ctgacctgtc tggtgaaggg cttctatcca agcgacatcg ctgtggagtg ggagtctaat     1560

ggccagcccg agaacaatta caagaccaca ccacccgtgc tggactctga tggctccttc     1620

tttctgtatt ctaggctgac agtggataag tcccggtggc aggagggcaa cgtgtttagc     1680

tgctctgtga tgcacgaggc cctgcacaat cattataccc agaagtccct gagcctgtct     1740

ctgggcaag                                                             1749


<210>  44
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of H5

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Val Thr Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Ser Gly Ser Ser Thr Ser Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Leu Gly Ala Val Val Tyr Thr Thr Arg Glu Pro Tyr Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Glu Val Gln Leu Val 
    130                 135                 140                 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
145                 150                 155                 160 


Cys Lys Ala Ser Gly Tyr Ser Phe Thr His His Trp Ile His Trp Val 
                165                 170                 175     


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Met Ile Asp Ala 
            180                 185                 190         


Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys Phe Lys Asp Arg Val Thr 
        195                 200                 205             


Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
    210                 215                 220                 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Gly Arg 
225                 230                 235                 240 


Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
            260                 265                 270         


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
        275                 280                 285             


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
    290                 295                 300                 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
305                 310                 315                 320 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
                325                 330                 335     


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
            340                 345                 350         


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
        355                 360                 365             


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    370                 375                 380                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
385                 390                 395                 400 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
                405                 410                 415     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
            420                 425                 430         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        435                 440                 445             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
    450                 455                 460                 


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
465                 470                 475                 480 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
                485                 490                 495     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            500                 505                 510         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        515                 520                 525             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    530                 535                 540                 


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
545                 550                 555                 560 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                565                 570                 575     


Leu Ser Leu Ser Leu Gly Lys 
            580             


<210>  45
<211>  1749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of H6

<400>  45
gaggtgcagc tggtggaatc cggcggaggc ctggtgcagc ctggcggctc tctgagactg       60

tcctgcgccg cttctggccg gaccttcatc acctacgcca tcggctggtt cagacaggcc      120

cctggcaagg gcagagagtt cgtgtccgcc atctcctggt ccggctctat gaccagctac      180

gccgactctg tgaagggcag attcaccatc tcccgggata acgccaagaa caccctgtac      240

ctgcagatga attccctgag acctgaggac acagctgtgt attactgcgc cgctcaccgg      300

ggcgccatcg ctcccatcgc tcagagcgtg tacaccaact ggggccaggg aaccctggtc      360

accgtgtcca gcgaacctaa gtctagcgac aaaactcata ccagcccccc tagtccagag      420

gtgcagctgg tgcagtccgg agctgaggtg aagaagccag gatccagcgt gaaggtgagc      480

tgcaaggcta gcggctactc tttcacccac cattggatcc actgggtgag gcaggctcct      540

ggacagggac tggagtggat gggcatgatc gacgcttccg atagcgagac aagactgtct      600

cagaagttta aggaccgcgt gaccatcaca gccgataagt ctacctccac agcttacatg      660

gagctgtctt ccctgagatc cgaggacacc gccgtgtact attgtgctag gctgggccgg      720

tactatttcg attattgggg ccagggcacc acagtgacag tgagctctgc cagcacaaag      780

ggcccttccg tgttcccact ggctccctgc tccagaagca catctgagtc caccgccgct      840

ctgggctgtc tggtgaagga ctacttccct gagccagtga ccgtgtcctg gaacagcggc      900

gccctgacat ctggcgtgca cacctttcca gctgtgctgc agtccagcgg cctgtactcc      960

ctgtcttccg tggtgacagt gcccagctct tccctgggca ccaagacata tacctgcaac     1020

gtggaccata agccttccaa taccaaggtg gataagaggg tggagagcaa gtacggacca     1080

ccttgcccac catgtccagc tcctgagttt gagggaggac catccgtgtt cctgtttcct     1140

ccaaagccta aggacaccct gatgatcagc cggacacctg aggtgacctg cgtggtggtg     1200

gacgtgtctc aggaggatcc agaggtgcag ttcaactggt acgtggatgg cgtggaggtg     1260

cacaatgcta agaccaagcc aagagaggag cagtttaatt ccacataccg cgtggtgagc     1320

gtgctgaccg tgctgcatca ggattggctg aacggcaagg agtataagtg caaggtgtcc     1380

aataagggcc tgcccagctc tatcgagaag acaatcagca aggctaaggg acagcctagg     1440

gagccacagg tgtacaccct gcccccttct caggaggaga tgacaaagaa ccaggtgtcc     1500

ctgacctgtc tggtgaaggg cttctatcca agcgacatcg ctgtggagtg ggagtctaat     1560

ggccagcccg agaacaatta caagaccaca ccacccgtgc tggactctga tggctccttc     1620

tttctgtatt ctaggctgac agtggataag tcccggtggc aggagggcaa cgtgtttagc     1680

tgctctgtga tgcacgaggc cctgcacaat cattataccc agaagtccct gagcctgtct     1740

ctgggcaag                                                             1749


<210>  46
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of H6

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ile Thr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Ser Gly Ser Met Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Gly Ala Ile Ala Pro Ile Ala Gln Ser Val Tyr Thr 
            100                 105                 110         


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Glu Val Gln Leu Val 
    130                 135                 140                 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
145                 150                 155                 160 


Cys Lys Ala Ser Gly Tyr Ser Phe Thr His His Trp Ile His Trp Val 
                165                 170                 175     


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Met Ile Asp Ala 
            180                 185                 190         


Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys Phe Lys Asp Arg Val Thr 
        195                 200                 205             


Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
    210                 215                 220                 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Gly Arg 
225                 230                 235                 240 


Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
            260                 265                 270         


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
        275                 280                 285             


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
    290                 295                 300                 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
305                 310                 315                 320 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
                325                 330                 335     


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
            340                 345                 350         


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
        355                 360                 365             


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    370                 375                 380                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
385                 390                 395                 400 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
                405                 410                 415     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
            420                 425                 430         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        435                 440                 445             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
    450                 455                 460                 


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
465                 470                 475                 480 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
                485                 490                 495     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            500                 505                 510         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        515                 520                 525             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    530                 535                 540                 


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
545                 550                 555                 560 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                565                 570                 575     


Leu Ser Leu Ser Leu Gly Lys 
            580             


<210>  47
<211>  1749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of H7

<400>  47
gaggtgcagc tggtgcagtc cggagctgag gtgaagaagc caggatccag cgtgaaggtg       60

agctgcaagg ctagcggcta ctctttcacc caccattgga tccactgggt gaggcaggct      120

cctggacagg gactggagtg gatgggcatg atcgacgctt ccgatagcga gacaagactg      180

tctcagaagt ttaaggaccg cgtgaccatc acagccgata agtctacctc cacagcttac      240

atggagctgt cttccctgag atccgaggac accgccgtgt actattgtgc taggctgggc      300

cggtactatt tcgattattg gggccagggc accacagtga cagtgagctc tgccagcaca      360

aagggccctt ccgtgttccc actggctccc tgctccagaa gcacatctga gtccaccgcc      420

gctctgggct gtctggtgaa ggactacttc cctgagccag tgaccgtgtc ctggaacagc      480

ggcgccctga catctggcgt gcacaccttt ccagctgtgc tgcagtccag cggcctgtac      540

tccctgtctt ccgtggtgac agtgcccagc tcttccctgg gcaccaagac atatacctgc      600

aacgtggacc ataagccttc caataccaag gtggataaga gggtggagag caagtacgga      660

ccaccttgcc caccatgtcc agctcctgag tttgagggag gaccatccgt gttcctgttt      720

cctccaaagc ctaaggacac cctgatgatc agccggacac ctgaggtgac ctgcgtggtg      780

gtggacgtgt ctcaggagga tccagaggtg cagttcaact ggtacgtgga tggcgtggag      840

gtgcacaatg ctaagaccaa gccaagagag gagcagttta attccacata ccgcgtggtg      900

agcgtgctga ccgtgctgca tcaggattgg ctgaacggca aggagtataa gtgcaaggtg      960

tccaataagg gcctgcccag ctctatcgag aagacaatca gcaaggctaa gggacagcct     1020

agggagccac aggtgtacac cctgccccct tctcaggagg agatgacaaa gaaccaggtg     1080

tccctgacct gtctggtgaa gggcttctat ccaagcgaca tcgctgtgga gtgggagtct     1140

aatggccagc ccgagaacaa ttacaagacc acaccacccg tgctggactc tgatggctcc     1200

ttctttctgt attctaggct gacagtggat aagtcccggt ggcaggaggg caacgtgttt     1260

agctgctctg tgatgcacga ggccctgcac aatcattata cccagaagtc cctgagcctg     1320

tctctgggca agggtggagg cggtagtgga ggcggtggtt caggcggagg cggatctgag     1380

gtgcagctgg tggaatccgg cggaggcctg gtccagcctg gcggctctct gcggctgtcc     1440

tgcgccgctt ctggcagaac cttcgtgacc tacggcatgg gctggttccg gcaggctcct     1500

ggcaagggca gagagttcgt gtccgccatc tcctggtccg gctccatgac ctcttacggc     1560

gactctgtga agggcagatt caccatcagc cgggataacg ccaagaacac actgtacctg     1620

cagatgaact ccctgcggcc tgaggacacc gccgtgtact actgcgccgc tgccctgggc     1680

gctgtcgtgt acaccaccag agaaccctat acctactggg gacagggcac cctggtgacc     1740

gtgtcctct                                                             1749


<210>  48
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of H7

<400>  48

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr His His 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asp Ala Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
    450                 455                 460                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
465                 470                 475                 480 


Cys Ala Ala Ser Gly Arg Thr Phe Val Thr Tyr Gly Met Gly Trp Phe 
                485                 490                 495     


Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val Ser Ala Ile Ser Trp 
            500                 505                 510         


Ser Gly Ser Met Thr Ser Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr 
        515                 520                 525             


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
    530                 535                 540                 


Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Leu Gly 
545                 550                 555                 560 


Ala Val Val Tyr Thr Thr Arg Glu Pro Tyr Thr Tyr Trp Gly Gln Gly 
                565                 570                 575     


Thr Leu Val Thr Val Ser Ser 
            580             


<210>  49
<211>  1749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of H8

<400>  49
gaggtgcagc tggtggaatc cggcggaggc ctggtccagc ctggcggctc tctgcggctg       60

tcctgcgccg cttctggcag aaccttcgtg acctacggca tgggctggtt ccggcaggct      120

cctggcaagg gcagagagtt cgtgtccgcc atctcctggt ccggctccat gacctcttac      180

ggcgactctg tgaagggcag attcaccatc agccgggata acgccaagaa cacactgtac      240

ctgcagatga actccctgcg gcctgaggac accgccgtgt actactgcgc cgctgccctg      300

ggcgctgtcg tgtacaccac cagagaaccc tatacctact ggggacaggg caccctggtg      360

accgtgtcct ctggtggagg cggtagtgga ggcggtggtt caggcggagg cggatctgag      420

gtgcagctgg tgcagtccgg agctgaggtg aagaagccag gatccagcgt gaaggtgagc      480

tgcaaggcta gcggctactc tttcacccac cattggatcc actgggtgag gcaggctcct      540

ggacagggac tggagtggat gggcatgatc gacgcttccg atagcgagac aagactgtct      600

cagaagttta aggaccgcgt gaccatcaca gccgataagt ctacctccac agcttacatg      660

gagctgtctt ccctgagatc cgaggacacc gccgtgtact attgtgctag gctgggccgg      720

tactatttcg attattgggg ccagggcacc acagtgacag tgagctctgc cagcacaaag      780

ggcccttccg tgttcccact ggctccctgc tccagaagca catctgagtc caccgccgct      840

ctgggctgtc tggtgaagga ctacttccct gagccagtga ccgtgtcctg gaacagcggc      900

gccctgacat ctggcgtgca cacctttcca gctgtgctgc agtccagcgg cctgtactcc      960

ctgtcttccg tggtgacagt gcccagctct tccctgggca ccaagacata tacctgcaac     1020

gtggaccata agccttccaa taccaaggtg gataagaggg tggagagcaa gtacggacca     1080

ccttgcccac catgtccagc tcctgagttt gagggaggac catccgtgtt cctgtttcct     1140

ccaaagccta aggacaccct gatgatcagc cggacacctg aggtgacctg cgtggtggtg     1200

gacgtgtctc aggaggatcc agaggtgcag ttcaactggt acgtggatgg cgtggaggtg     1260

cacaatgcta agaccaagcc aagagaggag cagtttaatt ccacataccg cgtggtgagc     1320

gtgctgaccg tgctgcatca ggattggctg aacggcaagg agtataagtg caaggtgtcc     1380

aataagggcc tgcccagctc tatcgagaag acaatcagca aggctaaggg acagcctagg     1440

gagccacagg tgtacaccct gcccccttct caggaggaga tgacaaagaa ccaggtgtcc     1500

ctgacctgtc tggtgaaggg cttctatcca agcgacatcg ctgtggagtg ggagtctaat     1560

ggccagcccg agaacaatta caagaccaca ccacccgtgc tggactctga tggctccttc     1620

tttctgtatt ctaggctgac agtggataag tcccggtggc aggagggcaa cgtgtttagc     1680

tgctctgtga tgcacgaggc cctgcacaat cattataccc agaagtccct gagcctgtct     1740

ctgggcaag                                                             1749


<210>  50
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of H8

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Val Thr Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Ser Gly Ser Met Thr Ser Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Leu Gly Ala Val Val Tyr Thr Thr Arg Glu Pro Tyr Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
    130                 135                 140                 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
145                 150                 155                 160 


Cys Lys Ala Ser Gly Tyr Ser Phe Thr His His Trp Ile His Trp Val 
                165                 170                 175     


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Met Ile Asp Ala 
            180                 185                 190         


Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys Phe Lys Asp Arg Val Thr 
        195                 200                 205             


Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
    210                 215                 220                 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Gly Arg 
225                 230                 235                 240 


Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
            260                 265                 270         


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
        275                 280                 285             


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
    290                 295                 300                 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
305                 310                 315                 320 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
                325                 330                 335     


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
            340                 345                 350         


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
        355                 360                 365             


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    370                 375                 380                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
385                 390                 395                 400 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
                405                 410                 415     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
            420                 425                 430         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        435                 440                 445             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
    450                 455                 460                 


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
465                 470                 475                 480 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
                485                 490                 495     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            500                 505                 510         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        515                 520                 525             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    530                 535                 540                 


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
545                 550                 555                 560 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                565                 570                 575     


Leu Ser Leu Ser Leu Gly Lys 
            580             


<210>  51
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of L1

<400>  51
gagatcgtgc tgacccagtc tccagccaca ctgtctctgt ccccaggaga gagggccacc       60

ctgagctgcc gggcttctga gaacgtgggc acatacatct cctggtatca gcagaagcca      120

ggacaggctc ctaggctgct gatctacggc gctagcaata gatataccgg catccctgct      180

cgcttcagcg gatctggatc cggcacagac tttaccctga caatctccag cctggagcca      240

gaggatttcg ccgtgtacta ttgtggcgag tcctacggcc acctgtatac ctttggcggc      300

ggcacaaagg tggagatcaa gcgaacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gtgaacctaa gtctagcgac      660

aaaactcata ccagcccccc tagtccagag gtgcagctgg tggaatccgg cggaggcctg      720

gtccagcctg gcggctctct gcggctgtcc tgcgccgctt ctggcagaac cttcgtgacc      780

tacggcatgg gctggttccg gcaggctcct ggcaagggca gagagttcgt gtccgccatc      840

tcctggtccg gctccatgac ctcttacggc gactctgtga agggcagatt caccatcagc      900

cgggataacg ccaagaacac actgtacctg cagatgaact ccctgcggcc tgaggacacc      960

gccgtgtact actgcgccgc tgccctgggc gctgtcgtgt acaccaccag agaaccctat     1020

acctactggg gacagggcac cctggtgacc gtgtcctct                            1059


<210>  52
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of L1

<400>  52

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          


Ile Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gly Glu Ser Tyr Gly His Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
    210                 215                 220                 


Ser Pro Pro Ser Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
225                 230                 235                 240 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
                245                 250                 255     


Thr Phe Val Thr Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
            260                 265                 270         


Gly Arg Glu Phe Val Ser Ala Ile Ser Trp Ser Gly Ser Met Thr Ser 
        275                 280                 285             


Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    290                 295                 300                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
305                 310                 315                 320 


Ala Val Tyr Tyr Cys Ala Ala Ala Leu Gly Ala Val Val Tyr Thr Thr 
                325                 330                 335     


Arg Glu Pro Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            340                 345                 350         


Ser 
    


<210>  53
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of L2

<400>  53
gagatcgtgc tgacccagtc tccagccaca ctgtctctgt ccccaggaga gagggccacc       60

ctgagctgcc gggcttctga gaacgtgggc acatacatct cctggtatca gcagaagcca      120

ggacaggctc ctaggctgct gatctacggc gctagcaata gatataccgg catccctgct      180

cgcttcagcg gatctggatc cggcacagac tttaccctga caatctccag cctggagcca      240

gaggatttcg ccgtgtacta ttgtggcgag tcctacggcc acctgtatac ctttggcggc      300

ggcacaaagg tggagatcaa gcgaacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gtgaacctaa gtctagcgac      660

aaaactcata ccagcccccc tagtccagag gtgcagctgg tggaatccgg cggaggcctg      720

gtccagcctg gcggctctct gcggctgtcc tgcgccgctt ctggcagaac cttcgtgacc      780

tacggcatgg gctggttccg gcaggctcct ggcaagggca gagagttcgt gtccgccatc      840

tcctggtccg gctccagcac ctcttacggc gactctgtga agggcagatt caccatcagc      900

cgggataacg ccaagaacac actgtacctg cagatgaact ccctgcggcc tgaggacacc      960

gccgtgtact actgcgccgc tgccctgggc gctgtcgtgt acaccaccag agaaccctat     1020

acctactggg gacagggcac cctggtgacc gtgtcctct                            1059


<210>  54
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of L2

<400>  54

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          


Ile Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gly Glu Ser Tyr Gly His Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
    210                 215                 220                 


Ser Pro Pro Ser Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
225                 230                 235                 240 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
                245                 250                 255     


Thr Phe Val Thr Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
            260                 265                 270         


Gly Arg Glu Phe Val Ser Ala Ile Ser Trp Ser Gly Ser Ser Thr Ser 
        275                 280                 285             


Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    290                 295                 300                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
305                 310                 315                 320 


Ala Val Tyr Tyr Cys Ala Ala Ala Leu Gly Ala Val Val Tyr Thr Thr 
                325                 330                 335     


Arg Glu Pro Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            340                 345                 350         


Ser 
    


<210>  55
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of L3

<400>  55
gagatcgtgc tgacccagtc tccagccaca ctgtctctgt ccccaggaga gagggccacc       60

ctgagctgcc gggcttctga gaacgtgggc acatacatct cctggtatca gcagaagcca      120

ggacaggctc ctaggctgct gatctacggc gctagcaata gatataccgg catccctgct      180

cgcttcagcg gatctggatc cggcacagac tttaccctga caatctccag cctggagcca      240

gaggatttcg ccgtgtacta ttgtggcgag tcctacggcc acctgtatac ctttggcggc      300

ggcacaaagg tggagatcaa gcgaacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gtgaacctaa gtctagcgac      660

aaaactcata ccagcccccc tagtccagag gtgcagctgg tggaatccgg cggaggcctg      720

gtgcagcctg gcggctctct gagactgtcc tgcgccgctt ctggccggac cttcatcacc      780

tacgccatcg gctggttcag acaggcccct ggcaagggca gagagttcgt gtccgccatc      840

tcctggtccg gctctatgac cagctacgcc gactctgtga agggcagatt caccatctcc      900

cgggataacg ccaagaacac cctgtacctg cagatgaatt ccctgagacc tgaggacaca      960

gctgtgtatt actgcgccgc tcaccggggc gccatcgctc ccatcgctca gagcgtgtac     1020

accaactggg gccagggaac cctggtcacc gtgtccagc                            1059


<210>  56
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of L3

<400>  56

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          


Ile Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gly Glu Ser Tyr Gly His Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
    210                 215                 220                 


Ser Pro Pro Ser Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
225                 230                 235                 240 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
                245                 250                 255     


Thr Phe Ile Thr Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys 
            260                 265                 270         


Gly Arg Glu Phe Val Ser Ala Ile Ser Trp Ser Gly Ser Met Thr Ser 
        275                 280                 285             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    290                 295                 300                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
305                 310                 315                 320 


Ala Val Tyr Tyr Cys Ala Ala His Arg Gly Ala Ile Ala Pro Ile Ala 
                325                 330                 335     


Gln Ser Val Tyr Thr Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            340                 345                 350         


Ser 
    


<210>  57
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of L4

<400>  57
gaggtgcagc tggtggaatc cggcggaggc ctggtccagc ctggcggctc tctgcggctg       60

tcctgcgccg cttctggcag aaccttcgtg acctacggca tgggctggtt ccggcaggct      120

cctggcaagg gcagagagtt cgtgtccgcc atctcctggt ccggctccat gacctcttac      180

ggcgactctg tgaagggcag attcaccatc agccgggata acgccaagaa cacactgtac      240

ctgcagatga actccctgcg gcctgaggac accgccgtgt actactgcgc cgctgccctg      300

ggcgctgtcg tgtacaccac cagagaaccc tatacctact ggggacaggg caccctggtg      360

accgtgtcct ctgaacctaa gtctagcgac aaaactcata ccagcccccc tagtccagag      420

atcgtgctga cccagtctcc agccacactg tctctgtccc caggagagag ggccaccctg      480

agctgccggg cttctgagaa cgtgggcaca tacatctcct ggtatcagca gaagccagga      540

caggctccta ggctgctgat ctacggcgct agcaatagat ataccggcat ccctgctcgc      600

ttcagcggat ctggatccgg cacagacttt accctgacaa tctccagcct ggagccagag      660

gatttcgccg tgtactattg tggcgagtcc tacggccacc tgtatacctt tggcggcggc      720

acaaaggtgg agatcaagcg aacggtggct gcaccatctg tcttcatctt cccgccatct      780

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      840

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      900

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      960

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg     1020

agctcgcccg tcacaaagag cttcaacagg ggagagtgt                            1059


<210>  58
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of L4

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Val Thr Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Ser Gly Ser Met Thr Ser Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Leu Gly Ala Val Val Tyr Thr Thr Arg Glu Pro Tyr Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Glu Ile Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
145                 150                 155                 160 


Ser Cys Arg Ala Ser Glu Asn Val Gly Thr Tyr Ile Ser Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn 
            180                 185                 190         


Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gly Glu Ser Tyr Gly His Leu Tyr Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
                245                 250                 255     


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
            260                 265                 270         


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
        275                 280                 285             


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
    290                 295                 300                 


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
305                 310                 315                 320 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
                325                 330                 335     


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
            340                 345                 350         


Cys 
    


<210>  59
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of L5

<400>  59
gaggtgcagc tggtggaatc cggcggaggc ctggtccagc ctggcggctc tctgcggctg       60

tcctgcgccg cttctggcag aaccttcgtg acctacggca tgggctggtt ccggcaggct      120

cctggcaagg gcagagagtt cgtgtccgcc atctcctggt ccggctccag cacctcttac      180

ggcgactctg tgaagggcag attcaccatc agccgggata acgccaagaa cacactgtac      240

ctgcagatga actccctgcg gcctgaggac accgccgtgt actactgcgc cgctgccctg      300

ggcgctgtcg tgtacaccac cagagaaccc tatacctact ggggacaggg caccctggtg      360

accgtgtcct ctgaacctaa gtctagcgac aaaactcata ccagcccccc tagtccagag      420

atcgtgctga cccagtctcc agccacactg tctctgtccc caggagagag ggccaccctg      480

agctgccggg cttctgagaa cgtgggcaca tacatctcct ggtatcagca gaagccagga      540

caggctccta ggctgctgat ctacggcgct agcaatagat ataccggcat ccctgctcgc      600

ttcagcggat ctggatccgg cacagacttt accctgacaa tctccagcct ggagccagag      660

gatttcgccg tgtactattg tggcgagtcc tacggccacc tgtatacctt tggcggcggc      720

acaaaggtgg agatcaagcg aacggtggct gcaccatctg tcttcatctt cccgccatct      780

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      840

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      900

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      960

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg     1020

agctcgcccg tcacaaagag cttcaacagg ggagagtgt                            1059


<210>  60
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of L5

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Val Thr Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Ser Gly Ser Ser Thr Ser Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Leu Gly Ala Val Val Tyr Thr Thr Arg Glu Pro Tyr Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Glu Ile Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
145                 150                 155                 160 


Ser Cys Arg Ala Ser Glu Asn Val Gly Thr Tyr Ile Ser Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn 
            180                 185                 190         


Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gly Glu Ser Tyr Gly His Leu Tyr Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
                245                 250                 255     


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
            260                 265                 270         


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
        275                 280                 285             


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
    290                 295                 300                 


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
305                 310                 315                 320 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
                325                 330                 335     


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
            340                 345                 350         


Cys 
    


<210>  61
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of L6

<400>  61
gaggtgcagc tggtggaatc cggcggaggc ctggtgcagc ctggcggctc tctgagactg       60

tcctgcgccg cttctggccg gaccttcatc acctacgcca tcggctggtt cagacaggcc      120

cctggcaagg gcagagagtt cgtgtccgcc atctcctggt ccggctctat gaccagctac      180

gccgactctg tgaagggcag attcaccatc tcccgggata acgccaagaa caccctgtac      240

ctgcagatga attccctgag acctgaggac acagctgtgt attactgcgc cgctcaccgg      300

ggcgccatcg ctcccatcgc tcagagcgtg tacaccaact ggggccaggg aaccctggtc      360

accgtgtcca gcgaacctaa gtctagcgac aaaactcata ccagcccccc tagtccagag      420

atcgtgctga cccagtctcc agccacactg tctctgtccc caggagagag ggccaccctg      480

agctgccggg cttctgagaa cgtgggcaca tacatctcct ggtatcagca gaagccagga      540

caggctccta ggctgctgat ctacggcgct agcaatagat ataccggcat ccctgctcgc      600

ttcagcggat ctggatccgg cacagacttt accctgacaa tctccagcct ggagccagag      660

gatttcgccg tgtactattg tggcgagtcc tacggccacc tgtatacctt tggcggcggc      720

acaaaggtgg agatcaagcg aacggtggct gcaccatctg tcttcatctt cccgccatct      780

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      840

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      900

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      960

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg     1020

agctcgcccg tcacaaagag cttcaacagg ggagagtgt                            1059


<210>  62
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of L6

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ile Thr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Ser Gly Ser Met Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Gly Ala Ile Ala Pro Ile Ala Gln Ser Val Tyr Thr 
            100                 105                 110         


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Glu Ile Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
145                 150                 155                 160 


Ser Cys Arg Ala Ser Glu Asn Val Gly Thr Tyr Ile Ser Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn 
            180                 185                 190         


Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gly Glu Ser Tyr Gly His Leu Tyr Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
                245                 250                 255     


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
            260                 265                 270         


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
        275                 280                 285             


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
    290                 295                 300                 


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
305                 310                 315                 320 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
                325                 330                 335     


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
            340                 345                 350         


Cys 
    


<210>  63
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of L7

<400>  63
gagatcgtgc tgacccagtc tccagccaca ctgtctctgt ccccaggaga gagggccacc       60

ctgagctgcc gggcttctga gaacgtgggc acatacatct cctggtatca gcagaagcca      120

ggacaggctc ctaggctgct gatctacggc gctagcaata gatataccgg catccctgct      180

cgcttcagcg gatctggatc cggcacagac tttaccctga caatctccag cctggagcca      240

gaggatttcg ccgtgtacta ttgtggcgag tcctacggcc acctgtatac ctttggcggc      300

ggcacaaagg tggagatcaa gcgaacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gtggtggagg cggtagtgga      660

ggcggtggtt caggcggagg cggatctgag gtgcagctgg tggaatccgg cggaggcctg      720

gtccagcctg gcggctctct gcggctgtcc tgcgccgctt ctggcagaac cttcgtgacc      780

tacggcatgg gctggttccg gcaggctcct ggcaagggca gagagttcgt gtccgccatc      840

tcctggtccg gctccatgac ctcttacggc gactctgtga agggcagatt caccatcagc      900

cgggataacg ccaagaacac actgtacctg cagatgaact ccctgcggcc tgaggacacc      960

gccgtgtact actgcgccgc tgccctgggc gctgtcgtgt acaccaccag agaaccctat     1020

acctactggg gacagggcac cctggtgacc gtgtcctct                            1059


<210>  64
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of L7

<400>  64

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          


Ile Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gly Glu Ser Tyr Gly His Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
225                 230                 235                 240 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
                245                 250                 255     


Thr Phe Val Thr Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
            260                 265                 270         


Gly Arg Glu Phe Val Ser Ala Ile Ser Trp Ser Gly Ser Met Thr Ser 
        275                 280                 285             


Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    290                 295                 300                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
305                 310                 315                 320 


Ala Val Tyr Tyr Cys Ala Ala Ala Leu Gly Ala Val Val Tyr Thr Thr 
                325                 330                 335     


Arg Glu Pro Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            340                 345                 350         


Ser 
    


<210>  65
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of L8

<400>  65
gaggtgcagc tggtggaatc cggcggaggc ctggtccagc ctggcggctc tctgcggctg       60

tcctgcgccg cttctggcag aaccttcgtg acctacggca tgggctggtt ccggcaggct      120

cctggcaagg gcagagagtt cgtgtccgcc atctcctggt ccggctccat gacctcttac      180

ggcgactctg tgaagggcag attcaccatc agccgggata acgccaagaa cacactgtac      240

ctgcagatga actccctgcg gcctgaggac accgccgtgt actactgcgc cgctgccctg      300

ggcgctgtcg tgtacaccac cagagaaccc tatacctact ggggacaggg caccctggtg      360

accgtgtcct ctggtggagg cggtagtgga ggcggtggtt caggcggagg cggatctgag      420

atcgtgctga cccagtctcc agccacactg tctctgtccc caggagagag ggccaccctg      480

agctgccggg cttctgagaa cgtgggcaca tacatctcct ggtatcagca gaagccagga      540

caggctccta ggctgctgat ctacggcgct agcaatagat ataccggcat ccctgctcgc      600

ttcagcggat ctggatccgg cacagacttt accctgacaa tctccagcct ggagccagag      660

gatttcgccg tgtactattg tggcgagtcc tacggccacc tgtatacctt tggcggcggc      720

acaaaggtgg agatcaagcg aacggtggct gcaccatctg tcttcatctt cccgccatct      780

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      840

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      900

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      960

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg     1020

agctcgcccg tcacaaagag cttcaacagg ggagagtgt                            1059


<210>  66
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of L8

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Val Thr Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Ser Gly Ser Met Thr Ser Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Leu Gly Ala Val Val Tyr Thr Thr Arg Glu Pro Tyr Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
145                 150                 155                 160 


Ser Cys Arg Ala Ser Glu Asn Val Gly Thr Tyr Ile Ser Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn 
            180                 185                 190         


Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gly Glu Ser Tyr Gly His Leu Tyr Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
                245                 250                 255     


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
            260                 265                 270         


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
        275                 280                 285             


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
    290                 295                 300                 


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
305                 310                 315                 320 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
                325                 330                 335     


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
            340                 345                 350         


Cys 


<210>  67
<211>  1050
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of L9

<400>  67
gagatcgtgc tgacccagtc tccagccaca ctgtctctgt ccccaggaga gagggccacc       60

ctgagctgcc gggcttctga gaacgtgggc acatacatct cctggtatca gcagaagcca      120

ggacaggctc ctaggctgct gatctacggc gctagcaata gatataccgg catccctgct      180

cgcttcagcg gatctggatc cggcacagac tttaccctga caatctccag cctggagcca      240

gaggatttcg ccgtgtacta ttgtggcgag tcctacggcc acctgtatac ctttggcggc      300

ggcacaaagg tggagatcaa gcgaacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gtgaatcgaa gtacggacct      660

ccatctccac ctagtccaga ggtgcagctg gtggaatccg gcggaggcct ggtccagcct      720

ggcggctctc tgcggctgtc ctgcgccgct tctggcagaa ccttcgtgac ctacggcatg      780

ggctggttcc ggcaggctcc tggcaagggc agagagttcg tgtccgccat ctcctggtcc      840

ggctccatga cctcttacgg cgactctgtg aagggcagat tcaccatcag ccgggataac      900

gccaagaaca cactgtacct gcagatgaac tccctgcggc ctgaggacac cgccgtgtac      960

tactgcgccg ctgccctggg cgctgtcgtg tacaccacca gagaacccta tacctactgg     1020 

ggacagggca ccctggtgac cgtgtcctct                                      1050


<210>  68
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of L9

<400>  68 

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30   


Ile Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45     


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65                  70                  75                  80


Glu Asp Phe Ala Val Tyr Tyr Cys Gly Glu Ser Tyr Gly His Leu Tyr
                85                  90                  95


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125   


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140          


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160   


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190  


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205


Phe Asn Arg Gly Glu Cys Glu Ser Lys Tyr Gly Pro Pro Ser Pro Pro
    210                 215                 220


Ser Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro
225                 230                 235                 240 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Val
                245                 250                 255


Thr Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu
            260                 265                 270


Phe Val Ser Ala Ile Ser Trp Ser Gly Ser Met Thr Ser Tyr Gly Asp
        275                 280                 285   


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr
    290                 295                 300 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr
305                 310                 315                 320  


Tyr Cys Ala Ala Ala Leu Gly Ala Val Val Tyr Thr Thr Arg Glu Pro
                325                 330                 335 


Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
            340                 345                 350


<210>  69
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of E4-Linker

<400>  69

Glu Ser Lys Tyr Gly Pro Pro Ser Pro Pro Ser Pro
1               5                   10

