                         SEQUENCE LISTING

<110>  SANFORD HEALTH
       VERMEER, Paola
 
<120>  Anti-human ephrin B1 antibodies and uses thereof

<130>  18-285-PCT

<150>  US 62/847,863
<151>  2019-05-14

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is T or D

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Y or F

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is N or Y

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is V, I, or M

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is H or N

<400>  1

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is V or I

<400>  2

Thr Tyr Asn Xaa His 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Thr Tyr Asn Val His 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Thr Tyr Asn Ile His 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Asp Phe Tyr Met Asn 
1               5   


<210>  6
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is F or absent

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is I or absent

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is R or absent

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is A or N

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is M or K

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is W or V

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is G or Y

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is R or G or T

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is S or P

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is A or S

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is F or V

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is S or G

<400>  6

Xaa Xaa Xaa Xaa Xaa Xaa Asn Gly Xaa Xaa Thr Asp Tyr Asn Xaa Xaa 
1               5                   10                  15      


Xaa Lys Xaa 
            


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is R or G

<400>  7

Ala Met Trp Asn Gly Gly Xaa Thr Asp Tyr Asn Ser Ala Phe Lys Ser 
1               5                   10                  15      


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Ala Met Trp Asn Gly Gly Arg Thr Asp Tyr Asn Ser Ala Phe Lys Ser 
1               5                   10                  15      


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Ala Met Trp Asn Gly Gly Gly Thr Asp Tyr Asn Ser Ala Phe Lys Ser 
1               5                   10                  15      


<210>  10
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Phe Ile Arg Asn Lys Val Asn Gly Tyr Thr Thr Asp Tyr Asn Pro Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is E or absent

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D or absent

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Y or absent

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Y or absent

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Y or absent

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is S or absent

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is G or absent

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is R or absent

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is L or P or F

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is D or T

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is D or Y

<400>  11

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Glu Asp Tyr Tyr Tyr Ser Gly Arg Phe Asp Tyr 
1               5                   10      


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is S or N

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is V or I

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is G or N

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is I or K

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is D or N or Y

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is V or L

<400>  13

Lys Ala Ser Gln Xaa Xaa Xaa Xaa Xaa Xaa Asp 
1               5                   10      


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is D or N

<400>  14

Lys Ala Ser Gln Ser Val Gly Ile Xaa Val Asp 
1               5                   10      


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Lys Ala Ser Gln Ser Val Gly Ile Asp Val Asp 
1               5                   10      


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 
1               5                   10      


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Lys Ala Ser Gln Asn Ile Asn Lys Tyr Leu Asp 
1               5                   10      


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is G or H

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is A or T

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is S or N

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is S or N

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is R or L

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is H or T

<400>  18

Xaa Xaa Xaa Xaa Xaa Xaa Thr 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is N or S

<400>  19

Gly Ala Ser Xaa Arg His Thr 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Gly Ala Ser Asn Arg His Thr 
1               5           


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Gly Ala Ser Ser Arg His Thr 
1               5           


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  22

His Thr Asn Asn Leu Gln Thr 
1               5           


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is H or Q

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Y or H

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is G or D

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is I or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is F or R

<400>  23

Leu Xaa Xaa Xaa Ser Xaa Pro Xaa Thr 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Leu His Tyr Gly Ser Ile Pro Phe Thr 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Leu Gln His Asp Ser Arg Pro Arg Thr 
1               5                   


<210>  26
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Optional leader sequence

<400>  26

Met Ala Val Leu Val Leu Leu Leu Cys Leu Val Thr Phe Pro Asn Ser 
1               5                   10                  15      


Val Leu Thr Gln Ile Gln Leu Lys Glu Thr Gly Pro Asp Leu Val Gln 
            20                  25                  30          


Leu Thr Gln Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Thr Tyr Asn Val His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Ala Met Trp Asn Gly Gly Arg Thr Asp Tyr Asn Ser 
65                  70                  75                  80  


Ala Phe Lys Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Asn Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Lys Tyr 
            100                 105                 110         


Phe Cys Ala Arg Leu Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val 
        115                 120                 125             


Ala Ser 
    130 


<210>  27
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Optional leader sequence

<400>  27

Met Ala Val Leu Val Leu Leu Leu Cys Leu Val Thr Phe Pro Asn Phe 
1               5                   10                  15      


Val Leu Thr Gln Val Gln Leu Lys Glu Thr Gly Pro Asp Leu Val His 
            20                  25                  30          


Leu Thr Gln Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Thr Tyr Asn Ile His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Ala Met Trp Asn Gly Gly Gly Thr Asp Tyr Asn Ser 
65                  70                  75                  80  


Ala Phe Lys Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Lys Tyr 
            100                 105                 110         


Phe Cys Ala Thr Pro Thr Asp Trp Gly Gln Gly Val Met Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  28
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Optional leader sequence

<400>  28

Met Lys Leu Trp Leu Asn Trp Ile Phe Leu Leu Thr Leu Leu Asn Gly 
1               5                   10                  15      


Leu Gln Cys Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Asp Ser Met Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Asp Phe Tyr Met Asn Trp Ile Arg Gln Pro Ala Gly Lys Ala Pro 
    50                  55                  60                  


Glu Trp Leu Gly Phe Ile Arg Asn Lys Val Asn Gly Tyr Thr Thr Asp 
65                  70                  75                  80  


Tyr Asn Pro Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Thr 
                85                  90                  95      


Gln Asn Met Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Thr Arg Glu Asp Tyr Tyr Tyr Ser Gly Arg Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser 
    130                 135                 140     


<210>  29
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Optional leader sequence

<400>  29

Met Glu Ser His Thr Arg Val Phe Ile Phe Leu Leu Leu Trp Leu Ser 
1               5                   10                  15      


Gly Ala Asp Gly Glu Thr Val Met Thr Gln Ser Pro Thr Ser Met Ser 
            20                  25                  30          


Thr Ser Ile Gly Glu Arg Val Thr Leu Asn Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Gly Ile Asp Val Asp Trp Tyr Gln Gln Thr Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Phe Gly Arg Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Glu Ala Glu Asp Leu Ala Val Tyr Tyr Cys Leu His Tyr Gly 
            100                 105                 110         


Ser Ile Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  30
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Optional leader seqeunce

<400>  30

Met Glu Ser His Thr Arg Val Phe Ile Phe Leu Leu Leu Trp Leu Ser 
1               5                   10                  15      


Gly Ala Asp Gly Glu Thr Val Met Thr Gln Ser Pro Thr Ser Met Ser 
            20                  25                  30          


Thr Ser Ile Gly Glu Arg Val Thr Leu Asn Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Thr Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Gly Ala Ser Ser Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Phe Gly Arg Asp Phe Thr Leu Thr Ile Thr 
                85                  90                  95      


Asn Val Glu Ala Glu Asp Leu Ala Val Tyr Tyr Cys Leu His Tyr Gly 
            100                 105                 110         


Ser Ile Pro Phe Thr Phe Gly Ser Gly Thr Arg Leu Glu Ile Lys 
        115                 120                 125         


<210>  31
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Optional leader seqeunce

<400>  31

Met Ala Ala Leu Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro Ala 
1               5                   10                  15      


Met Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Asn Ile 
        35                  40                  45              


Asn Lys Tyr Leu Asp Trp Tyr His Gln Asn His Gly Glu Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr His Thr Asn Asn Leu Gln Thr Gly Ile Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Val Ala Thr Tyr Phe Cys Leu Gln His Asp Ser 
            100                 105                 110         


Arg Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Asp Leu Lys 
        115                 120                 125     


<210>  32
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Lys Asn Leu Glu Pro Val Ser Trp Ser Ser Leu Asn Pro Lys Phe Leu 
1               5                   10                  15      


Ser Gly Lys Gly Leu Val Ile Tyr Pro Lys Ile Gly Asp Lys Leu 
            20                  25                  30      


<210>  33
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Ser Trp Ser Ser Leu Asn Pro Lys Phe Leu Ser Gly Lys Gly 
1               5                   10                  


<210>  34
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Lys Asn Leu Glu Pro Val Ser Trp Ser Ser Leu Asn Pro Lys Phe Leu 
1               5                   10                  15      


Ser Gly Lys Gly 
            20  


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Ser Gly Lys Gly Leu Val Ile Tyr Pro Lys Ile Gly Asp Lys Leu 
1               5                   10                  15  


<210>  36
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  36

Met Ala Arg Pro Gly Gln Arg Trp Leu Gly Lys Trp Leu Val Ala Met 
1               5                   10                  15      


Val Val Trp Ala Leu Cys Arg Leu Ala Thr Pro Leu Ala Lys Asn Leu 
            20                  25                  30          


Glu Pro Val Ser Trp Ser Ser Leu Asn Pro Lys Phe Leu Ser Gly Lys 
        35                  40                  45              


Gly Leu Val Ile Tyr Pro Lys Ile Gly Asp Lys Leu Asp Ile Ile Cys 
    50                  55                  60                  


Pro Arg Ala Glu Arg Pro Tyr Glu Tyr Tyr Lys Leu Tyr Leu Val Arg 
65                  70                  75                  80  


Pro Glu Gln Ala Ala Ala Cys Ser Thr Val Leu Asp Pro Asn Val Leu 
                85                  90                  95      


Val Thr Cys Asn Arg Pro Glu Gln Glu Ile Arg Phe Thr Ile Lys Phe 
            100                 105                 110         


Gln Glu Phe Ser Pro Asn Tyr Met Gly Leu Glu Phe Lys Lys His His 
        115                 120                 125             


Asp Tyr Tyr Ile Thr Ser Thr Ser Asn Gly Ser Leu Glu Gly Leu Glu 
    130                 135                 140                 


Asn Arg Glu Gly Gly Val Cys Arg Thr Arg Thr Met Lys Ile Ile Met 
145                 150                 155                 160 


Lys Val Gly Gln Asp Pro Asn Ala Val Thr Pro Glu Gln Leu Thr Thr 
                165                 170                 175     


Ser Arg Pro Ser Lys Glu Ala Asp Asn Thr Val Lys Met Ala Thr Gln 
            180                 185                 190         


Ala Pro Gly Ser Arg Gly Ser Leu Gly Asp Ser Asp Gly Lys His Glu 
        195                 200                 205             


Thr Val Asn Gln Glu Glu Lys Ser Gly Pro Gly Ala Ser Gly Gly Ser 
    210                 215                 220                 


Ser Gly Asp Pro Asp Gly Phe Phe Asn Ser Lys Val Ala Leu Phe Ala 
225                 230                 235                 240 


Ala Val Gly Ala Gly Cys Val Ile Phe Leu Leu Ile Ile Ile Phe Leu 
                245                 250                 255     


Thr Val Leu Leu Leu Lys Leu Arg Lys Arg His Arg Lys His Thr Gln 
            260                 265                 270         


Gln Arg Ala Ala Ala Leu Ser Leu Ser Thr Leu Ala Ser Pro Lys Gly 
        275                 280                 285             


Gly Ser Gly Thr Ala Gly Thr Glu Pro Ser Asp Ile Ile Ile Pro Leu 
    290                 295                 300                 


Arg Thr Thr Glu Asn Asn Tyr Cys Pro His Tyr Glu Lys Val Ser Gly 
305                 310                 315                 320 


Asp Tyr Gly His Pro Val Tyr Ile Val Gln Glu Met Pro Pro Gln Ser 
                325                 330                 335     


Pro Ala Asn Ile Tyr Tyr Lys Val 
            340                 


<210>  37
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Met Ala Arg Pro Gly Gln Arg Trp Leu Gly Lys Trp Leu Val Ala Met 
1               5                   10                  15      


Val Val Trp Ala Leu Cys Arg Leu Ala Thr Pro Leu Ala Lys Asn Leu 
            20                  25                  30          


Glu Pro Val Ser Trp Ser Ser Leu Asn Pro Lys Phe Leu Ser Gly Lys 
        35                  40                  45              


Gly Leu Val Ile Tyr Pro Lys Ile Gly Asp Lys Leu Asp Ile Ile Cys 
    50                  55                  60                  


Pro Arg Ala Glu Arg Pro Tyr Glu Tyr Tyr Lys Leu Tyr Leu Val Arg 
65                  70                  75                  80  


Pro Glu Gln Ala Ala Ala Cys Ser Thr Val Leu Asp Pro Asn Val Leu 
                85                  90                  95      


Val Thr Cys Asn Arg Pro Glu Gln Glu Ile Arg Phe Thr Ile Lys Phe 
            100                 105                 110         


Gln Glu Phe Ser Pro Asn Tyr Met Gly Leu Glu Phe Lys Lys His His 
        115                 120                 125             


Asp Tyr Tyr Ile Thr Ser Thr Ser Asn Gly Ser Leu Glu Gly Leu Glu 
    130                 135                 140                 


Asn Arg Glu Gly Gly Val Cys Arg Thr Arg Thr Met Lys Ile Ile Met 
145                 150                 155                 160 


Lys Val Gly Gln Asp Pro Asn Ala Val Thr Pro Glu Gln Leu Thr Thr 
                165                 170                 175     


Ser Arg Pro Ser Lys Glu Ala Asp Asn Thr Val Lys Met Ala Thr Gln 
            180                 185                 190         


Ala Pro Gly Ser Arg Gly Ser Leu Gly Asp Ser Asp Gly Lys His Glu 
        195                 200                 205             


Thr Val Asn Gln Glu Glu Lys Ser Gly Pro Gly Ala Ser Gly Gly Ser 
    210                 215                 220                 


Ser Gly Asp Pro Asp Gly Phe Phe Asn Ser Lys 
225                 230                 235 


<210>  38
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  38

Met Ser Asp Gly Asp Tyr Asp Tyr Leu Ile Lys Phe Leu Ala Leu Gly 
1               5                   10                  15      


Asp Ser Gly Val Gly Lys Thr Ser Val Leu Tyr Gln Tyr Thr Asp Gly 
            20                  25                  30          


Lys Phe Asn Ser Lys Phe Ile Thr Thr Val Gly Ile Asp Phe Arg Glu 
        35                  40                  45              


Lys Arg Val Val Tyr Arg Ala Ser Gly Pro Asp Gly Ala Thr Gly Arg 
    50                  55                  60                  


Gly Gln Arg Ile His Leu Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg 
65                  70                  75                  80  


Phe Arg Ser Leu Thr Thr Ala Phe Phe Arg Asp Ala Met Gly Phe Leu 
                85                  90                  95      


Leu Leu Phe Asp Leu Thr Asn Glu Gln Ser Phe Leu Asn Val Arg Asn 
            100                 105                 110         


Trp Ile Ser Gln Leu Gln Met His Ala Tyr Cys Glu Asn Pro Asp Ile 
        115                 120                 125             


Val Leu Cys Gly Asn Lys Ser Asp Leu Glu Asp Gln Arg Val Val Lys 
    130                 135                 140                 


Glu Glu Glu Ala Ile Ala Leu Ala Glu Lys Tyr Gly Ile Pro Tyr Phe 
145                 150                 155                 160 


Glu Thr Ser Ala Ala Asn Gly Thr Asn Ile Ser Gln Ala Ile Glu Met 
                165                 170                 175     


Leu Leu Asp Leu Ile Met Lys Arg Met Glu Arg Cys Val Asp Lys Ser 
            180                 185                 190         


Trp Ile Pro Glu Gly Val Val Arg Ser Asn Gly His Ala Ser Thr Asp 
        195                 200                 205             


Gln Leu Ser Glu Glu Lys Glu Lys Gly Ala Cys Gly Cys 
    210                 215                 220     


<210>  39
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Met Thr Asp Gly Asp Tyr Asp Tyr Leu Ile Lys Leu Leu Ala Leu Gly 
1               5                   10                  15      


Asp Ser Gly Val Gly Lys Thr Thr Phe Leu Tyr Arg Tyr Thr Asp Asn 
            20                  25                  30          


Lys Phe Asn Pro Lys Phe Ile Thr Thr Val Gly Ile Asp Phe Arg Glu 
        35                  40                  45              


Lys Arg Val Val Tyr Asn Ala Gln Gly Pro Asn Gly Ser Ser Gly Lys 
    50                  55                  60                  


Ala Phe Lys Val His Leu Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg 
65                  70                  75                  80  


Phe Arg Ser Leu Thr Thr Ala Phe Phe Arg Asp Ala Met Gly Phe Leu 
                85                  90                  95      


Leu Met Phe Asp Leu Thr Ser Gln Gln Ser Phe Leu Asn Val Arg Asn 
            100                 105                 110         


Trp Met Ser Gln Leu Gln Ala Asn Ala Tyr Cys Glu Asn Pro Asp Ile 
        115                 120                 125             


Val Leu Ile Gly Asn Lys Ala Asp Leu Pro Asp Gln Arg Glu Val Asn 
    130                 135                 140                 


Glu Arg Gln Ala Arg Glu Leu Ala Asp Lys Tyr Gly Ile Pro Tyr Phe 
145                 150                 155                 160 


Glu Thr Ser Ala Ala Thr Gly Gln Asn Val Glu Lys Ala Val Glu Thr 
                165                 170                 175     


Leu Leu Asp Leu Ile Met Lys Arg Met Glu Gln Cys Val Glu Lys Thr 
            180                 185                 190         


Gln Ile Pro Asp Thr Val Asn Gly Gly Asn Ser Gly Asn Leu Asp Gly 
        195                 200                 205             


Glu Lys Pro Pro Glu Lys Lys Cys Ile Cys 
    210                 215             


