                         SEQUENCE LISTING

<110>  The Research Foundation for The State University of New 
       York
 
<120>  COMPOSITIONS AND METHODS TO BLOCK AND BIND CCR2 TO MODULATE 
       CELLULAR FUNCTION

<130>  011520.01502

<150>  62/846,947
<151>  2019-05-13

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Asp Tyr Lys Asp Asp Asp Asp Lys Leu Gln Ala 
            20                  25                  30          


Val Leu Thr Gln Pro Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala 
        35                  40                  45              


Ser Leu Thr Cys Ile Leu Arg Ser Asp Phe Ser Val Val Thr Gln Arg 
    50                  55                  60                  


Val Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Arg Tyr Leu Leu 
65                  70                  75                  80  


Arg Tyr Asn Ser Asp Ser Asp Lys Arg Leu Gly Ser Gly Val Pro Ser 
                85                  90                  95      


Arg Phe Ser Gly Ser Lys Asp Val Ser Ala Asn Ala Ala Ser Leu Leu 
            100                 105                 110         


Ile Ser Gly Leu Gln Ser Asp Asp Glu Ala Asp Tyr Tyr Cys Val Ile 
        115                 120                 125             


Trp His Asn Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
    130                 135                 140                 


Leu Gly Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ala Ser 
145                 150                 155                 160 


Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
                165                 170                 175     


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            180                 185                 190         


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        195                 200                 205             


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    210                 215                 220                 


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
225                 230                 235                 240 


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                245                 250                 255     


Ala Arg Arg Pro Gln Tyr Tyr Asp Ile Leu Thr Gly Trp His Ala Gly 
            260                 265                 270         


Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val 
        275                 280                 285             


Glu Ala Ser Ala Ala Ala Leu Asp Tyr Lys Asp Asp Asp Asp Lys Leu 
    290                 295                 300                 


Asp His His His His His His 
305                 310     


<210>  2
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Asp Tyr Lys Asp Asp Asp Asp Lys Leu Gln Ser 
            20                  25                  30          


Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln Lys Val 
        35                  40                  45              


Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val 
    50                  55                  60                  


Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


Gly Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
                85                  90                  95      


Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly 
            100                 105                 110         


Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu Ser Ala 
        115                 120                 125             


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Glu Gly Lys 
    130                 135                 140                 


Ser Ser Gly Ser Gly Ser Glu Ser Lys Ala Ser Gln Val Thr Leu Lys 
145                 150                 155                 160 


Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
                165                 170                 175     


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Tyr Ile His Trp Val 
            180                 185                 190         


Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro 
        195                 200                 205             


Ser Asp Gly Arg Thr Thr Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
    210                 215                 220                 


Met Thr Arg Asp Thr Ser Thr Ser Thr Leu Tyr Met Glu Leu Thr Ser 
225                 230                 235                 240 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg Gly Gly His 
                245                 250                 255     


Tyr Ser Asn Tyr Phe Gly Gln Pro Ser Thr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ser Val Glu Ala Ser Ala Ala Ala Leu Asp Tyr Lys 
        275                 280                 285             


Asp Asp Asp Asp Lys Leu Asp His His His His His His 
    290                 295                 300     


<210>  3
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Asp Tyr Lys Asp Asp Asp Asp Lys Leu Gln Ser 
            20                  25                  30          


Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val 
    50                  55                  60                  


Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
                85                  90                  95      


Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu 
            100                 105                 110         


Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly 
        115                 120                 125             


Val Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu Gly Glu Gly Lys 
    130                 135                 140                 


Ser Ser Gly Ser Gly Ser Glu Ser Lys Ala Ser Gln Val Thr Leu Lys 
145                 150                 155                 160 


Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
                165                 170                 175     


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Tyr Ile His Trp Val 
            180                 185                 190         


Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro 
        195                 200                 205             


Ser Asp Gly Arg Thr Thr Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
    210                 215                 220                 


Met Thr Arg Asp Thr Ser Thr Ser Thr Leu Tyr Met Glu Leu Thr Ser 
225                 230                 235                 240 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg Gly Gly His 
                245                 250                 255     


Tyr Ser Asn Tyr Phe Gly Gln Pro Ser Thr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ser Val Glu Ala Ser Ala Ala Ala Leu Asp Tyr Lys 
        275                 280                 285             


Asp Asp Asp Asp Lys Leu Asp His His His His His His 
    290                 295                 300     


<210>  4
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Asp Tyr Lys Asp Asp Asp Asp Lys Leu Glu Val 
            20                  25                  30          


Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
        35                  40                  45              


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Met 
    50                  55                  60                  


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile 
65                  70                  75                  80  


Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln Gly 
                85                  90                  95      


Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu 
            100                 105                 110         


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        115                 120                 125             


Asp Gly Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ala 
145                 150                 155                 160 


Ser Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro 
                165                 170                 175     


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
            180                 185                 190         


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        195                 200                 205             


Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 
225                 230                 235                 240 


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser 
                245                 250                 255     


Pro Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys Val Glu 
            260                 265                 270         


Ala Ser Ala Ala Ala Leu Asp Tyr Lys Asp Asp Asp Asp Lys Leu Asp 
        275                 280                 285             


His His His His His His 
    290                 


<210>  5
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Asp Tyr Lys Asp Asp Asp Asp Lys Leu Glu Ile 
            20                  25                  30          


Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg 
        35                  40                  45              


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu 
    50                  55                  60                  


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
65                  70                  75                  80  


Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
            100                 105                 110         


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Leu Thr Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Gly Lys Ser Ser Gly Ser 
    130                 135                 140                 


Gly Ser Glu Ser Lys Ala Ser Glu Val Gln Leu Leu Glu Ser Gly Ala 
145                 150                 155                 160 


Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Thr Ser 
                165                 170                 175     


Gly Tyr Thr Phe Thr Thr Tyr Asp Ile Tyr Trp Met Arg Leu Ala Thr 
            180                 185                 190         


Gly Gln Arg Leu Glu Trp Met Gly Trp Val Asn Pro Asp Asn Gly Lys 
        195                 200                 205             


Thr Asp Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Ser Arg Asp 
    210                 215                 220                 


Ser Ser Ile Asn Thr Val Phe Met Glu Leu Ser Asn Leu Arg Leu Glu 
225                 230                 235                 240 


Asp Thr Ala Ile Tyr Phe Cys Ala Arg Ala Leu Thr Arg Trp Gln Gln 
                245                 250                 255     


Ser Pro Leu Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Val Glu Ala Ser Ala Ala Ala Leu Asp Tyr Lys Asp Asp Asp Asp Lys 
        275                 280                 285             


Leu Asp His His His His His His 
    290                 295     


<210>  6
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Asp Tyr Lys Asp Asp Asp Asp Lys Leu Gln Ser 
            20                  25                  30          


Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser His Thr Val 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
                85                  90                  95      


Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu 
            100                 105                 110         


Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly 
        115                 120                 125             


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Glu Gly Lys 
    130                 135                 140                 


Ser Ser Gly Ser Gly Ser Glu Ser Lys Ala Ser Gln Val Thr Leu Lys 
145                 150                 155                 160 


Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
                165                 170                 175     


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Tyr Ile His Trp Val 
            180                 185                 190         


Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro 
        195                 200                 205             


Ser Asp Gly Arg Thr Thr Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
    210                 215                 220                 


Met Thr Arg Asp Thr Ser Thr Ser Thr Leu Tyr Met Glu Leu Thr Ser 
225                 230                 235                 240 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg Gly Gly His 
                245                 250                 255     


Tyr Ser Asn Tyr Phe Gly Gln Pro Ser Thr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ser Val Glu Ala Ser 
        275                 280     


<210>  7
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Asp Tyr Lys Asp Asp Asp Asp Lys Leu Gln Pro 
            20                  25                  30          


Val Leu Thr Gln Pro Ser Ser Ala Ser Gly Thr Pro Gly Gln Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val 
    50                  55                  60                  


Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
                85                  90                  95      


Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu 
            100                 105                 110         


Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Thr Leu Ile Gly 
        115                 120                 125             


Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Glu Gly Lys 
    130                 135                 140                 


Ser Ser Gly Ser Gly Ser Glu Ser Lys Ala Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Thr Leu Ser 
                165                 170                 175     


Cys Ala Val Ser Gly Phe Pro Phe Ser Asp Ala Trp Met Asn Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Arg Ile Arg Ser 
        195                 200                 205             


Lys Ala Gly Gly Gly Thr Thr Asp Ser Ala Ala Pro Val Lys Asp Arg 
    210                 215                 220                 


Phe Thr Phe Ser Gly Asp Asp Ser Lys Asn Thr Val Tyr Val Glu Met 
225                 230                 235                 240 


Asn Ser Leu Lys Ile Glu Asp Thr Ala Val Tyr Tyr Cys Thr Gly Glu 
                245                 250                 255     


Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Glu Ala 
            260                 265                 270         


Ser 
    


<210>  8
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  8

Ile Leu Arg Ser Asp Phe Ser Val Val Thr Gln Arg Val Tyr 
1               5                   10                  


<210>  9
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  9

Thr Tyr Asp Ile Tyr 
1               5   


<210>  10
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  10
ccctgtatgc ctctggtc                                                     18


<210>  11
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  11
gtctttacgg atgtcaacg                                                    19


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  12
tttgcttcca tgctaatgcg aaag                                              24


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  13
gctctgttga ggtctaaagg ctccg                                             25


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  14
tgggaaatcg tggaaatgag                                                   20


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  15
ctgaaggact ctggctttgt c                                                 21


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  16
cagaagaatg gaagagtcag                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  17
cagatatgca gggagtcacc                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  18
agcgggaaga gaaaaaccag                                                   20


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  19
agatgaccac cagtagcagg ag                                                22


<210>  20
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  20

Ala Ala Asn Glu Trp Val Phe Gly Asn Ile Met Cys Lys 
1               5                   10              


<210>  21
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  21

Gln Glu Ser Leu Gly Met Ser Asn Cys Val Ile Asp Lys His Leu Asp 
1               5                   10                  15      


Gln Lys 
        


<210>  22
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  22

Asn Ser Asp Ser Asp Lys Arg Leu Gly Ser 
1               5                   10  


<210>  23
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  23

Val Ile Trp His Asn Ser Ala Val Val 
1               5                   


<210>  24
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  24

Ser Tyr Trp Ile Gly 
1               5   


<210>  25
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  25

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  26
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  26

Arg Pro Gln Tyr Tyr Asp Ile Leu Thr Gly Trp His Ala Gly 
1               5                   10                  


<210>  27
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  27

Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  28
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  28

Gly Asn Asn Lys Arg Pro Ser 
1               5           


<210>  29
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  29

Ala Thr Trp Asp Asp Ser Leu Ser Ala Val Val 
1               5                   10      


<210>  30
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  30

Asn Phe Tyr Ile His 
1               5   


<210>  31
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  31

Ile Ile Asn Pro Ser Asp Gly Arg Thr Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  32

Gly Gly His Tyr Ser Asn Tyr Phe Gly Gln 
1               5                   10  


<210>  33
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  33

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 
1               5                   10              


<210>  34
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  34

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  35
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  35

Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 
1               5                   10      


<210>  36
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  36

Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Met His 
1               5                   10              


<210>  37
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  37

Asn Pro Ser Gly Gly Ser Thr 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  38

Ala Arg Asp Gly Asn Trp Phe Asp Pro 
1               5                   


<210>  39
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  39

Ser Ser Tyr Leu Ala 
1               5   


<210>  40
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  40

Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
1               5                   10                  15      


Gly 
    


<210>  41
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  41

Gln Tyr Gly Ser Ser 
1               5   


<210>  42
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  42

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  43
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  43

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  44
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Gln Tyr Gly Ser Ser Leu Thr 
1               5               


<210>  45
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  45

Trp Val Asn Pro Asp Asn Gly Lys Thr Asp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  46
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  46

Ala Leu Thr Arg Trp Gln Gln Ser 
1               5               


<210>  47
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  47

Ser Gly Ser Ser Ser Asn Ile Gly Ser His Thr Val Asn 
1               5                   10              


<210>  48
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  48

Ala Ala Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  49
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  49

Gly Gly His Tyr Ser Asn Tyr Phe Gly Gln Pro Ser Thr 
1               5                   10              


<210>  50
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  50

Ala Ala Trp Asp Asp Thr Leu Ile Gly Pro Val 
1               5                   10      


<210>  51
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  51

Asp Ala Trp Met Asn 
1               5   


<210>  52
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  52

Arg Ile Arg Ser Lys Ala Gly Gly Gly Thr Thr Asp Ser Ala Ala Pro 
1               5                   10                  15      


Val Lys Asp 
            


<210>  53
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  53

Leu Gln Ala Val Leu Thr Gln Pro Ser Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Ala Ser Ala Ser Leu Thr Cys Ile Leu Arg Ser Asp Phe Ser Val Val 
            20                  25                  30          


Thr Gln Arg Val Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Arg 
        35                  40                  45              


Tyr Leu Leu Arg Tyr Asn Ser Asp Ser Asp Lys Arg Leu Gly Ser Gly 
    50                  55                  60                  


Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Val Ser Ala Asn Ala Ala 
65                  70                  75                  80  


Ser Leu Leu Ile Ser Gly Leu Gln Ser Asp Asp Glu Ala Asp Tyr Tyr 
                85                  90                  95      


Cys Val Ile Trp His Asn Ser Ala Val Val Phe Gly Gly Gly Thr Lys 
            100                 105                 110         


Leu Thr Val Leu Gly Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser 
        115                 120                 125             


Lys Ala Ser Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
145                 150                 155                 160 


Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser 
            180                 185                 190         


Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
        195                 200                 205             


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Arg Pro Gln Tyr Tyr Asp Ile Leu Thr Gly Trp 
225                 230                 235                 240 


His Ala Gly Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser 
        


<210>  54
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  54

Leu Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly 
1               5                   10                  15      


Gln Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser 
                85                  90                  95      


Leu Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ala Ser Gln Val 
        115                 120                 125             


Thr Leu Lys Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
    130                 135                 140                 


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Tyr Ile 
145                 150                 155                 160 


His Trp Val Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile 
                165                 170                 175     


Ile Asn Pro Ser Asp Gly Arg Thr Thr Tyr Ala Gln Lys Phe Gln Gly 
            180                 185                 190         


Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Leu Tyr Met Glu 
        195                 200                 205             


Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg 
    210                 215                 220                 


Gly Gly His Tyr Ser Asn Tyr Phe Gly Gln Pro Ser Thr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser 
                245             


<210>  55
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  55

Leu Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly 
1               5                   10                  15      


Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser 
            20                  25                  30          


Asn Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Val Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu Gly 
            100                 105                 110         


Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ala Ser Gln Val 
        115                 120                 125             


Thr Leu Lys Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
    130                 135                 140                 


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Tyr Ile 
145                 150                 155                 160 


His Trp Val Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile 
                165                 170                 175     


Ile Asn Pro Ser Asp Gly Arg Thr Thr Tyr Ala Gln Lys Phe Gln Gly 
            180                 185                 190         


Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Leu Tyr Met Glu 
        195                 200                 205             


Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg 
    210                 215                 220                 


Gly Gly His Tyr Ser Asn Tyr Phe Gly Gln Pro Ser Thr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser 
                245             


<210>  56
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  56

Leu Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Gly Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu 
        115                 120                 125             


Ser Lys Ala Ser Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser 
    130                 135                 140                 


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
145                 150                 155                 160 


Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
                165                 170                 175     


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
    210                 215                 220                 


Gly Ser Ser Pro Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  57
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  57

Leu Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
            20                  25                  30          


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Gly Lys Ser 
            100                 105                 110         


Ser Gly Ser Gly Ser Glu Ser Lys Ala Ser Glu Val Gln Leu Leu Glu 
        115                 120                 125             


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
    130                 135                 140                 


Lys Thr Ser Gly Tyr Thr Phe Thr Thr Tyr Asp Ile Tyr Trp Met Arg 
145                 150                 155                 160 


Leu Ala Thr Gly Gln Arg Leu Glu Trp Met Gly Trp Val Asn Pro Asp 
                165                 170                 175     


Asn Gly Lys Thr Asp Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile 
            180                 185                 190         


Ser Arg Asp Ser Ser Ile Asn Thr Val Phe Met Glu Leu Ser Asn Leu 
        195                 200                 205             


Arg Leu Glu Asp Thr Ala Ile Tyr Phe Cys Ala Arg Ala Leu Thr Arg 
    210                 215                 220                 


Trp Gln Gln Ser Pro Leu Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  58
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Glu Asp Asn Asn Met Leu Pro Gln Phe Ile His Gly Ile Leu Ser 
1               5                   10                  15      


Thr Ser His Ser Leu Phe Thr Arg Ser Ile Gln Glu Leu Asp Glu Gly 
            20                  25                  30          


Ala Thr Thr Pro Tyr Asp Tyr Asp Asp Gly Glu Pro Cys 
        35                  40                  45  


<210>  59
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  59

Gly Ser Gly Ser Gly Ser 
1               5       


<210>  60
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  60

Thr Lys Cys Gln Lys Glu Asp Ser Val Tyr Val Cys Gly Pro Tyr Phe 
1               5                   10                  15      


Pro Arg Gly Trp Asn Asn Phe His Thr Ile Met Arg 
            20                  25              


<210>  61
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  61

Leu Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
            20                  25                  30          


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Gly Lys Ser 
            100                 105                 110         


Ser Gly Ser Gly Ser Glu Ser Lys Ala Ser Glu Val Gln Leu Leu Glu 
        115                 120                 125             


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
    130                 135                 140                 


Lys Thr Ser Gly Tyr Thr Phe Thr Thr Tyr Asp Ile Tyr Trp Met Arg 
145                 150                 155                 160 


Leu Ala Thr Gly Gln Arg Leu Glu Trp Met Gly Trp Val Asn Pro Asp 
                165                 170                 175     


Asn Gly Lys Thr Asp Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile 
            180                 185                 190         


Ser Arg Asp Ser Ser Ile Asn Thr Val Phe Met Glu Leu Ser Asn Leu 
        195                 200                 205             


Arg Leu Glu Asp Thr Ala Ile Tyr Phe Cys Ala Arg Ala Leu Thr Arg 
    210                 215                 220                 


Trp Gln Gln Ser Pro Leu Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser 
        


