                         SEQUENCE LISTING

<110>  Biosion Inc.
 
<120>  ANTIBODY BINDING CSF-1R AND USE THEREOF

<130>  55532 00016

<150>  US62/847,950
<151>  2019-05-15

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 for mouse, chimeric and humanized 1G8

<400>  1

Asp Tyr Asn Met Asp 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 for mouse and chimeric 2B6

<400>  2

Asp Phe Asn Ile His 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 for mouse 2B7

<400>  3

Ile Tyr Ser Val His 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 for mouse 1D10-1

<400>  4

Lys Tyr Trp Ile Gly 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 for mouse 2B12 and 1H8

<400>  5

Thr Asn Asp Val His 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 for mouse 3B1

<400>  6

Ile Asn Asp Val His 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 for mouse 1F7-2

<400>  7

Ser Ser His Ile His 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 for mouse, chimeric and humanized 1G8

<400>  8

Asp Ile Asn Pro Asn Tyr Glu Ser Thr Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 for mouse and chimeric 2B6

<400>  9

Tyr Ile His Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 for mouse 2B7

<400>  10

Val Ile Trp Gly Gly Gly Thr Thr His Tyr Asn Ser Thr Leu Lys Ser 
1               5                   10                  15      


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 for mouse 1D10-1

<400>  11

Asp Ile Tyr Pro Gly Ser Ile Tyr Asn Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 for mouse 2B12, 1H8 and 3B1

<400>  12

Ala Ile Arg Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 for mouse 1F7-2

<400>  13

Val Ile Trp Ala Gly Gly Thr Thr Thr Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 for mouse, chimeric and humanized 1G8

<400>  14

Gly Gly His Gly Ser Arg Asp Trp Tyr Phe Asp Val 
1               5                   10          


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 for mouse and chimeric 2B6

<400>  15

Trp Asp Gly Gly Ser Tyr Ala Ala Met Asp Tyr 
1               5                   10      


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 for mouse 2B7

<400>  16

Asn Gly Gly Leu Leu Tyr Ser Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 for mouse 1D10-1

<400>  17

Asn His Arg Tyr Asp Arg Ser Phe Ala Tyr 
1               5                   10  


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 for mouse 2B12 and 3B1

<400>  18

Val Gly Leu Arg Trp Tyr Tyr Ala Met Tyr His 
1               5                   10      


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 for mouse and chimeric 1H8

<400>  19

Val Gly Leu Arg Trp Tyr Tyr Ala Met Tyr Tyr 
1               5                   10      


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 for mouse 1F7-2

<400>  20

Gly His Leu Arg Tyr Ser Tyr Gly Met Asp Asn 
1               5                   10      


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1 for mouse, chimeric and humanized 1G8

<400>  21

Lys Ala Ser Asp His Ile Asn Asn Trp Leu Ala 
1               5                   10      


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1 for mouse and chimeric 2B6

<400>  22

Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Ala 
1               5                   10      


<210>  23
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1 for mouse 2B7

<400>  23

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1 for mouse 1D10-1

<400>  24

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1 for mouse 2B12, 1H8 and 3B1

<400>  25

Arg Ser Asn Gln Ser Leu Ile His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  26
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1 for mouse 1F7-2

<400>  26

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Ile His 
1               5                   10                  15      


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2 for mouse, chimeric and humanized 1G8

<400>  27

Gly Ala Thr Arg Leu Glu Thr 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2 for mouse and chimeric 2B6

<400>  28

Gly Ala Thr Ser Leu Glu Thr 
1               5           


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2 for mouse 2B7, 2B12 and 1H8

<400>  29

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2 for mouse 1D10-1

<400>  30

Gln Met Ser Asn Leu Ala Ser 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2 for mouse 1F7-2

<400>  31

Lys Val Ser Ser Arg Phe Ser 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 for mouse, chimeric and humanized 1G8

<400>  32

Gln Gln Tyr Trp Ser Ile Pro Tyr Thr 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 for mouse and chimeric 2B6

<400>  33

Gln Gln Tyr Trp Ser Ile Pro Trp Thr 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 for mouse 2B7 and 1F7-2

<400>  34

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 for mouse 1D10-1

<400>  35

Gly Gln Asn Leu Glu Phe Pro Trp Thr 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 for mouse 2B12, 1H8, and 3B1

<400>  36

Ser Gln Ser Thr His Val Pro Phe Thr 
1               5                   


<210>  37
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for mouse and chimeric 1G8

<400>  37

Glu Val Gln Leu Gln Gln Phe Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Met Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Tyr Glu Ser Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly His Gly Ser Arg Asp Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  38
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for hu1G8-V1, hu1G8-V4, hu1G8-V7, hu1G8-V10 and hu1G8-V13

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa can be Arg or Val

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa can be Thr or Arg

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  Xaa can be Val or Ala

<400>  38

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Tyr Glu Ser Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Xaa Asp Xaa Ser Thr Ser Thr Xaa Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly His Gly Ser Arg Asp Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  39
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for mouse and chimeric 2B6

<400>  39

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Phe 
            20                  25                  30          


Asn Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile His Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Tyr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Ala Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Gly Gly Ser Tyr Ala Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  40
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for mouse 2B7

<400>  40

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ile Tyr 
            20                  25                  30          


Ser Val His Trp Leu Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Thr Thr His Tyr Asn Ser Thr Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Ile Ser Lys Gly Gln Phe Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asn Gly Gly Leu Leu Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Ala Ser Val Thr Val Ser Ser 
        115                 120 


<210>  41
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for mouse 1D10-1

<400>  41

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ala Gly Tyr Thr Phe Thr Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Ile Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Ser Ile Tyr Asn Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Val Ser Ser Leu Thr Tyr Glu Asp Ser Ala Asn Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn His Arg Tyr Asp Arg Ser Phe Ala Tyr Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  42
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for mouse 2B12

<400>  42

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Asn 
            20                  25                  30          


Asp Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Ala Ile Arg Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Lys Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Gly Leu Arg Trp Tyr Tyr Ala Met Tyr His Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  43
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for mouse and chimeric 1H8

<400>  43

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Asn 
            20                  25                  30          


Asp Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Ala Ile Arg Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Gly Leu Arg Trp Tyr Tyr Ala Met Tyr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  44
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for mouse 3B1

<400>  44

Gln Val Leu Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ile Asn 
            20                  25                  30          


Asp Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Ala Ile Arg Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Lys Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Gly Leu Arg Trp Tyr Tyr Ala Met Tyr His Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  45
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for mouse 1F7-2

<400>  45

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Ser 
            20                  25                  30          


His Ile His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Thr Thr Thr Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Thr Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Gly His Leu Arg Tyr Ser Tyr Gly Met Asp Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  46
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for mouse and chimeric 1G8

<400>  46

Asp Ile Gln Met Thr Gln Ser Ser Ser Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Arg Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Pro Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  47
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for hu1G8-V1 - hu1G8-V3

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa can be Leu or IIe

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa can be Tyr or Ser

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa can be Thr or Lys

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa can be Leu or Pro

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Xaa 
        35                  40                  45              


Xaa Gly Ala Thr Arg Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Xaa Asp Tyr Thr Leu Thr Ile Ser Ser Xaa Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  48
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for mouse and chimeric 2B6

<400>  48

Asp Ile Gln Met Thr Gln Ser Ser Ser Ser Phe Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  49
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for mouse 2B7

<400>  49

Asp Val Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Glu Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Arg 
            100                 105                 110         


<210>  50
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for mouse 1D10-1

<400>  50

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gly Gln Asn 
                85                  90                  95      


Leu Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  51
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for mouse 2B12

<400>  51

Asp Val Val Met Thr Gln Pro Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Asn Gln Ser Leu Ile His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Val Lys Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Ser Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  52
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for mouse and chimeric 1H8

<400>  52

Asp Val Val Met Thr Gln Pro Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Asn Gln Ser Leu Ile His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Ser Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  53
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for mouse 3B1

<400>  53

Asp Val Val Met Thr Gln Pro Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Asn Gln Ser Leu Ile His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Val Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Ser Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  54
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for mouse 1F7-2

<400>  54

Asp Val Val Met Thr Gln Val Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Ile His Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Ser Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Met Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  55
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain constant region for chimeric and humanized antibodies
       1G8

<400>  55

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  56
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain constant region for chimeric and humanized antibodies
       1G8

<400>  56

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  57
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain for cabiralizumab

<400>  57

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Asn Tyr Met Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Asn Pro Tyr Asn Gly Gly Thr Thr Phe Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Ser Pro Tyr Phe Ser Asn Leu Tyr Val Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Leu Gly 
465         


<210>  58
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain for cabiralizumab

<400>  58

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ser Arg Cys Asn Ile Val Leu Thr Gln Ser Pro Ala Thr 
            20                  25                  30          


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser 
        35                  40                  45              


Gln Ser Val Asp Tyr Asp Gly Asp Asn Tyr Met Asn Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ala Ala Ser Asn Leu 
65                  70                  75                  80  


Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr 
            100                 105                 110         


Tyr Cys His Leu Ser Asn Glu Asp Leu Ser Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  59
<211>  972
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg 
    130                 135                 140                 


Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser 
    290                 295                 300                 


Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn 
305                 310                 315                 320 


Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp 
                325                 330                 335     


Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala 
            340                 345                 350         


Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu 
        355                 360                 365             


Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg 
    370                 375                 380                 


Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr 
385                 390                 395                 400 


Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr 
                405                 410                 415     


Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu 
            420                 425                 430         


Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln 
        435                 440                 445             


Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His 
    450                 455                 460                 


Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn 
465                 470                 475                 480 


Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp 
                485                 490                 495     


Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu 
            500                 505                 510         


Phe Leu Phe Thr Pro Val Val Val Ala Cys Met Ser Ile Met Ala Leu 
        515                 520                 525             


Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro 
    530                 535                 540                 


Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser 
545                 550                 555                 560 


Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu 
                565                 570                 575     


Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala 
            580                 585                 590         


Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp 
        595                 600                 605             


Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala 
    610                 615                 620                 


Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu 
625                 630                 635                 640 


Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly 
                645                 650                 655     


Gly Pro Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu 
            660                 665                 670         


Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser 
        675                 680                 685             


Pro Gly Gln Asp Pro Glu Gly Gly Val Asp Tyr Lys Asn Ile His Leu 
    690                 695                 700                 


Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val 
705                 710                 715                 720 


Asp Thr Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Asn Asp Ser 
                725                 730                 735     


Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu 
            740                 745                 750         


Arg Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe 
        755                 760                 765             


Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val 
    770                 775                 780                 


Leu Leu Thr Asn Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala 
785                 790                 795                 800 


Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg 
                805                 810                 815     


Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr 
            820                 825                 830         


Thr Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile 
        835                 840                 845             


Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys 
    850                 855                 860                 


Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe 
865                 870                 875                 880 


Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu 
                885                 890                 895     


Pro Thr His Arg Pro Thr Phe Gln Gln Ile Cys Ser Phe Leu Gln Glu 
            900                 905                 910         


Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp Tyr Thr Asn Leu Pro Ser 
        915                 920                 925             


Ser Ser Arg Ser Gly Gly Ser Gly Ser Ser Ser Ser Glu Leu Glu Glu 
    930                 935                 940                 


Glu Ser Ser Ser Glu His Leu Thr Cys Cys Glu Gln Gly Asp Ile Ala 
945                 950                 955                 960 


Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe Cys 
                965                 970         


<210>  60
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CSF1-his protein

<400>  60

Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
1               5                   10                  15      


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
            20                  25                  30          


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
        35                  40                  45              


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
    50                  55                  60                  


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
65                  70                  75                  80  


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
                85                  90                  95      


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
            100                 105                 110         


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
        115                 120                 125             


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
    130                 135                 140                 


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn His His 
145                 150                 155                 160 


His His His His 
                


<210>  61
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CSF1R Fc protein

<400>  61

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ser Arg Cys Ile Pro Val Ile Glu Pro Ser Val Pro Glu 
            20                  25                  30          


Leu Val Val Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn 
        35                  40                  45              


Gly Ser Val Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr 
    50                  55                  60                  


Ser Asp Gly Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln 
65                  70                  75                  80  


Asn Thr Gly Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly 
                85                  90                  95      


Ser Ala Ala Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn 
            100                 105                 110         


Val Leu Ala Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu 
        115                 120                 125             


Pro Cys Leu Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val 
    130                 135                 140                 


Arg Val Arg Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser 
145                 150                 155                 160 


Pro Trp His Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln 
                165                 170                 175     


Asp Tyr Gln Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile 
            180                 185                 190         


Ser Ile Arg Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu 
        195                 200                 205             


Thr Leu Val Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln 
    210                 215                 220                 


Ile Val Cys Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu 
225                 230                 235                 240 


Gln His Asn Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His 
                245                 250                 255     


Asn Asn Arg Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp 
            260                 265                 270         


Phe Gln His Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly 
        275                 280                 285             


Lys His Ser Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu 
    290                 295                 300                 


Asn Leu Ser Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu 
305                 310                 315                 320 


Gly Leu Asn Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly 
                325                 330                 335     


Phe Asn Trp Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro 
            340                 345                 350         


Lys Leu Ala Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr 
        355                 360                 365             


Leu Ser Leu Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe 
    370                 375                 380                 


Leu Ala Arg Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr 
385                 390                 395                 400 


Leu Arg Tyr Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly 
                405                 410                 415     


Ser Gly Thr Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val 
            420                 425                 430         


Thr Trp Leu Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln 
        435                 440                 445             


Val Leu Gln Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu 
    450                 455                 460                 


Pro Phe His Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu 
465                 470                 475                 480 


Glu His Asn Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser 
                485                 490                 495     


Gly Ser Trp Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro 
            500                 505                 510         


Pro Asp Glu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
        515                 520                 525             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    530                 535                 540                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
545                 550                 555                 560 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                565                 570                 575     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            580                 585                 590         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        595                 600                 605             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    610                 615                 620                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
625                 630                 635                 640 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
                645                 650                 655     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            660                 665                 670         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        675                 680                 685             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    690                 695                 700                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
705                 710                 715                 720 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                725                 730                 735     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745         


<210>  62
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyno CSF1R-his protein

<400>  62

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Ile Pro Val Ile Glu Pro Ser Gly Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Glu Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Ile Ser Pro His Trp Thr Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Pro Ser Ser Val Leu Thr Thr Asn Asn Ala Thr Phe Gln Asn Thr Arg 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Arg Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Lys Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Leu Arg 
    130                 135                 140                 


Gly Arg Pro Leu Leu Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Ile Ile His Arg Ala Lys Phe Ile Gln Gly Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Glu Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Asn Ile Asp Val Asp Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Thr Thr Lys Leu Ala Ile Pro Gln Arg Ser Asp Phe His Asp Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Thr Leu Ser Leu Gly Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asp Leu Ser 
    290                 295                 300                 


Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn 
305                 310                 315                 320 


Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp 
                325                 330                 335     


Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala 
            340                 345                 350         


Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu 
        355                 360                 365             


Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg 
    370                 375                 380                 


Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr 
385                 390                 395                 400 


Pro Pro Glu Val Ser Val Ile Trp Thr Ser Ile Asn Gly Ser Gly Thr 
                405                 410                 415     


Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu 
            420                 425                 430         


Gln Cys Ala Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln 
        435                 440                 445             


Val Trp Val Asp Pro His Pro Glu Val Leu Ser Gln Glu Pro Phe Gln 
    450                 455                 460                 


Lys Val Thr Val Gln Ser Leu Leu Thr Thr Glu Thr Leu Glu His Asn 
465                 470                 475                 480 


Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp 
                485                 490                 495     


Ala Phe Ile Pro Ile Ser Ala Gly Ala Arg Thr His Pro Pro Asp Glu 
            500                 505                 510         


Phe Leu Phe Thr Pro His His His His His His 
        515                 520             


<210>  63
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for mouse 1G8

<400>  63
gaggtccagc tgcaacagtt tggagctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggcta cacattcagt gactacaaca tggactgggt gaagcagagc      120

catggaatga gccttgagtg gattggagat attaatccca actatgaaag tactacctac      180

aaccagaagt tcaagggaaa ggccacattg actgtagaca ggtcctccag tacagcctac      240

atggagctcc gcagcctgac atctgaggac actgcagtct atttctgtgc aagaggaggc      300

cacggtagta gggactggta cttcgatgtc tggggcgcag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  64
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for chimeric 1G8

<400>  64
gaggtgcagc tgcagcagtt cggcgccgag ctggtgaagc ctggcgcctc tgtgaagatg       60

agctgtaagg cctccggcta cacattcagc gattacaaca tggattgggt gaagcagtcc      120

cacggcatga gcctggagtg gatcggcgat atcaatccca actacgagag caccacatac      180

aaccagaagt tcaagggcaa ggccaccctg acagtggaca ggagcagctc cacagcctac      240

atggagctga ggagcctgac atccgaggat accgccgtgt acttctgtgc cagaggcggc      300

cacggctcca gagattggta cttcgacgtg tggggcgccg gcaccaccgt gacagtgagc      360

agc                                                                    363


<210>  65
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for hu1G8-V2, hu1G8-V5, hu1G8-V8, hu1G8-V11 and hu1G8-V14

<400>  65
caggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggcgcttc cgtgaaggtg       60

agctgtaagg ccagcggcta caccttctcc gactacaata tggactgggt gaggcaggcc      120

cctggccagg gactggagtg gatgggcgac atcaacccta attacgagtc cacaacatac      180

aatcagaagt tcaagggcag ggtgaccatg accgtggaca ggagcacatc cacagcctac      240

atggagctga gcagcctgag atccgaggac acagccgtgt actactgcgc cagaggcggc      300

cacggctcca gagactggta cttcgatgtg tggggccagg gcaccctggt gaccgtgtcc      360

agc                                                                    363


<210>  66
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for mouse 1G8

<400>  66
gacatccaga tgacacaatc ttcatcctac ttgtctgtat ctctaggagg cagagtcacc       60

attacttgca aggcaagtga ccacattaat aattggttag cctggtatca gcagaaacca      120

ggaaatgctc ctaggctctt aatatctggt gcaaccagat tggaaactgg ggttccttca      180

agattcagtg gcagtggatc tggaaaggat tacactctca gcataaccag tcctcagact      240

gaagatgttg ctacttatta ctgtcaacag tattggagta ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  67
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for chimeric 1G8

<400>  67
gatatccaga tgacccagag cagctcctac ctgagcgtga gcctgggcgg cagggtgacc       60

atcacatgca aggccagcga tcacatcaac aactggctgg cctggtatca acagaagcct      120

ggcaatgccc ccagactgct gatcagcggc gccaccaggc tggagacagg cgtgccatcc      180

aggttctccg gctccggctc cggaaaggat tacacactgt ccatcacatc cccccagacc      240

gaggacgtgg ccacctacta ctgccagcag tactggagca tcccttacac cttcggcggc      300

ggcaccaagc tggagatcaa g                                                321


<210>  68
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for hu1G8-V13 - hu1G8-V15

<400>  68
gatatccaga tgacccagtc cccctccagc ctgtccgcct ccgtgggaga tagagtgacc       60

atcacctgta aggccagcga tcacatcaac aattggctgg cctggtatca acagaagccc      120

ggcaaggccc ccaagctgct gctgtacggc gccaccaggc tggagacagg cgtgcctagc      180

aggttctccg gctccggctc cggaacagac tacaccctga ccatctccag cctgcagcct      240

gaggacttcg ccacatacta ctgccagcag tactggagca tcccctacac cttcggccag      300

ggcaccaagc tggagatcaa g                                                321


<210>  69
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain constant region for chimeric and humanized antibodies
       1G8

<400>  69
gccagcacaa agggcccttc cgtgtttccc ctggccccct gcagcaggag cacctctgag       60

tccaccgccg ccctgggctg tctggtgaag gactactttc ccgagcccgt gaccgtgagc      120

tggaattccg gcgccctgac atccggcgtg cacaccttcc ccgccgtgct gcagtcctcc      180

ggcctgtaca gcctgagctc cgtggtgaca gtgccttcct cctccctggg caccaagacc      240

tacacatgta atgtggatca caagcccagc aacacaaagg tggataagag agtggagtcc      300

aagtacggcc ctccttgccc tccctgtcct gccccagagt tcctgggcgg cccctctgtg      360

ttcctgttcc cccctaagcc caaggacaca ctgatgatct ccaggacccc tgaggtgacc      420

tgcgtggtgg tggacgtgag ccaggaggac cctgaggtgc agttcaattg gtacgtggat      480

ggcgtggagg tgcacaatgc caagacaaag cccagagagg agcagtttaa ttccacatac      540

agggtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa ggagtacaag      600

tgtaaggtga gcaacaaggg cctgccttcc tccatcgaga agacaatcag caaggccaag      660

ggccagccta gggagcccca ggtgtacaca ctgcctccca gccaggagga gatgaccaag      720

aaccaggtga gcctgacctg cctggtgaag ggcttctacc ctagcgacat cgccgtggag      780

tgggagtcca acggccagcc cgagaataac tacaagacaa caccccccgt gctggattcc      840

gatggcagct tctttctgta ctccaggctg accgtggata agagcaggtg gcaggagggc      900

aatgtgttca gctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagagc      960

ctgtccctga gcctgggcaa g                                                981


<210>  70
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain constant region for chimeric and humanized antibodies
       1G8

<400>  70
cgtacggtgg cggcgccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg ttga                                             324


