                         SEQUENCE LISTING

<110>  THE TEXAS A&M UNIVERSITY SYSTEM
 
<120>  PROTEIN INHIBITORS OF CLOSTRIDIUM DIFFICILE TOXIN B

<130>  13260-P158WO

<150>  US 62/846,650
<151>  2019-05-11

<150>  US 62/900,855
<151>  2019-09-16

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1.2E

<400>  1

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Tyr Asp Ala Arg Gly Val Thr Pro Leu His Leu Ala Ala Phe Ser Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Ile Asp Val Ile Gly Met Thr Pro Leu His Leu Ala Ala Trp Ile 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Val Asp Arg Ser Gly Asn Thr Pro Leu His Leu Ala Ala Trp 
            100                 105                 110         


Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  2
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1.4E

<400>  2

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Thr Asp His Leu Gly Val Thr Pro Leu His Leu Ala Ala Val Leu Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Tyr Asp Ile Leu Gly Arg Thr Pro Leu His Leu Ala Ala Trp Arg 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Asp Asp Thr Ser Gly Thr Thr Pro Leu His Leu Ala Ala Gly 
            100                 105                 110         


Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  3
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1.8H

<400>  3

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Ile Asp Ala Leu Gly Val Thr Pro Leu His Leu Ala Ala Trp Val Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Val Asp Val Leu Gly Trp Thr Pro Leu His Leu Ala Ala Trp Lys 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Met Asp Asn Arg Gly Pro Thr Pro Leu His Leu Ala Ala Val 
            100                 105                 110         


Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  4
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1.11E

<400>  4

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Thr Asp His Leu Gly Val Thr Pro Leu His Leu Ala Ala Val Leu Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Tyr Asp Ile Leu Gly Arg Thr Pro Leu His Leu Ala Ala Trp Arg 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Val Asp Thr Met Gly Glu Thr Pro Leu His Leu Ala Ala Gly 
            100                 105                 110         


Met Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  5
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5.8B

<400>  5

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Leu Asp Thr His Gly Val Thr Pro Leu His Leu Ala Ala Trp Arg Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Gly Asp Val Leu Gly Arg Thr Pro Leu His Leu Ala Ala Thr Phe 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Ile 
                85                  90                  95      


Asn Ala Val Asp Thr Val Gly Val Thr Pro Leu His Leu Ala Ala Gly 
            100                 105                 110         


Gln Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  6
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5.5A

<400>  6

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Val Asp Arg Ala Gly Thr Thr Pro Leu His Leu Ala Ala His Gly Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Arg Asp Leu Leu Gly Arg Thr Pro Leu His Leu Ala Ala Trp Arg 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Ser Asp Pro Leu Gly Ile Thr Pro Leu His Leu Ala Ala Ala 
            100                 105                 110         


Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  7
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7.5A

<400>  7

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Leu Asp Thr His Gly Val Thr Pro Leu His Leu Ala Ala Trp Arg Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Gly Asp Val Leu Gly Arg Thr Pro Leu His Leu Ala Ala Thr Phe 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Val Asp Thr Val Gly Val Thr Pro Leu His Leu Ala Ala Gly 
            100                 105                 110         


Gln Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  8
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5.9C

<400>  8

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Gln Asp Tyr Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Trp Leu Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Gly Asp Leu Leu Gly Arg Thr Pro Leu His Leu Ala Ala Trp Phe 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Val Asp Thr Met Gly Glu Thr Pro Leu His Leu Ala Ala Gly 
            100                 105                 110         


Met Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  9
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3.11H

<400>  9

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Thr Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Lys Asp Glu Gly Gly Pro Thr Pro Leu His Leu Ala Ala Val Gly Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Val Asp Ala Leu Gly Arg Thr Pro Leu His Leu Ala Ala Trp Gln 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Arg Asp Lys Asn Gly Tyr Thr Pro Leu His Leu Ala Ala Gly 
            100                 105                 110         


Met Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  10
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3.5B

<400>  10

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Lys Asp Thr Phe Gly Glu Thr Pro Leu His Leu Ala Ala Trp Lys Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Ser Asp Leu Leu Gly Arg Thr Pro Leu His Leu Ala Ala Trp Arg 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Ser Asp Thr Gly Gly Tyr Thr Pro Leu His Leu Ala Ala Ala 
            100                 105                 110         


Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  11
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8.1B

<400>  11

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Lys Asp Gly Ser Gly Val Thr Pro Leu His Leu Ala Ala Val Ala Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Arg Asp Arg Leu Gly Arg Thr Pro Leu His Leu Ala Ala Trp Arg 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Lys Asp Leu Gly Gly Asp Thr Pro Leu His Leu Ala Ala Ala 
            100                 105                 110         


Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  12
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3.9G

<400>  12

Gly Ser Asp Leu Gly Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp 
1               5                   10                  15      


Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Asn 
            20                  25                  30          


Asp Arg Arg Gly Ile Thr Pro Leu His Leu Ala Ala Ile Asn Gly His 
        35                  40                  45              


Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala 
    50                  55                  60                  


Val Asp Val Leu Gly Phe Thr Pro Leu His Leu Ala Ala Trp Arg Gly 
65                  70                  75                  80  


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
                85                  90                  95      


Ala Phe Asp Lys Ser Gly Ser Thr Pro Leu His Leu Ala Ala His Phe 
            100                 105                 110         


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
        115                 120                 125             


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
    130                 135                 140                 


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155             


<210>  13
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U3

<400>  13

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Asp Asp Arg Ile Gly Met Thr Pro Leu His Leu Ala Ala Ile Gly Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Asp Asp Val His Gly Arg Thr Pro Leu His Leu Ala Ala Gly Arg 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu His Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Pro Asp Arg Trp Gly Arg Thr Pro Leu His Leu Ala Ala His His Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Ser 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155         


<210>  14
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U5

<400>  14

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Asp Asp Arg Ile Gly Met Thr Pro Leu His Leu Ala Ala Ile Gly Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Asp Asp Val His Gly Arg Thr Pro Leu His Leu Ala Ala Gly Arg 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
            100                 105                 110         


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
        115                 120                 125     


<210>  15
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TEMP

<400>  15

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Asn Asp Arg Arg Gly Ile Thr Pro Leu His Leu Ala Ala Ile Asn Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Val Asp Val Leu Gly Phe Thr Pro Leu His Leu Ala Ala Trp Arg 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Phe Asp Lys Ser Gly Ser Thr Pro Leu His Leu Ala Ala His 
            100                 105                 110         


Phe Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  16
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D3

<400>  16

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Ala Asp Arg Tyr Gly Pro Thr Pro Leu His Leu Ala Ala Tyr Arg Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Lys Asp Val Leu Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ile 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Val Asp Val Thr Gly Glu Thr Pro Leu His Leu Ala Ala Val 
            100                 105                 110         


Met Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  17
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D10

<400>  17

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Ala Asp Arg Tyr Gly Pro Thr Pro Leu His Leu Ala Ala Tyr Arg Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Lys Asp Val Leu Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ile 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Val Asp Val Thr Gly Glu Thr Pro Leu His Leu Ala Ala Val 
            100                 105                 110         


Met Gly His Leu Glu Ile Ala Glu Val Leu Leu Lys His Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  18
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D13

<400>  18

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Val Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Ala Asp Arg Tyr Gly Pro Thr Pro Leu His Leu Ala Ala Tyr Arg Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Lys Asp Val Leu Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ile 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Val Asp Val Thr Gly Glu Thr Pro Leu His Leu Ala Ala Val 
            100                 105                 110         


Met Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  19
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D7

<400>  19

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Ala Asp Arg Tyr Gly Pro Thr Pro Leu His Leu Ala Ala Tyr Arg Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Lys Asp Val Leu Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ile 
65                  70                  75                  80  


Gly His Pro Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Val Asp Val Thr Gly Glu Thr Pro Leu His Leu Ala Ala Val 
            100                 105                 110         


Met Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  20
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D9

<400>  20

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Ala Asp Arg Tyr Gly Pro Thr Pro Leu His Leu Ala Ala Tyr Arg Gly 
        35                  40                  45              


His Leu Glu Ile Ala Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Lys Asp Val Leu Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ile 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Val Asp Val Thr Gly Glu Thr Pro Leu His Leu Ala Ala Val 
            100                 105                 110         


Met Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  21
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D6

<400>  21

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Ala Asp Arg Tyr Gly Pro Thr Pro Leu His Leu Ala Ala Tyr Arg Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Lys Asp Val Leu Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ile 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Pro Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Val Asp Val Thr Gly Glu Thr Pro Leu His Leu Ala Ala Val 
            100                 105                 110         


Met Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  22
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D15

<400>  22

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Ala Asp Arg Tyr Gly Pro Thr Pro Leu His Leu Ala Ala Tyr Arg Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Lys Asp Val Leu Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ile 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Val Asp Val Thr Gly Glu Thr Pro Leu His Leu Ala Ala Val 
            100                 105                 110         


Met Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  23
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D16

<400>  23

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Ala Asp Arg Tyr Gly Pro Thr Pro Leu His Leu Ala Ala Tyr Arg Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Lys Asp Val Leu Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ile 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Arg Asp Arg Thr Gly Glu Thr Pro Leu His Leu Ala Ala Ala 
            100                 105                 110         


Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  24
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D8

<400>  24

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Ala Asp Arg Tyr Gly Pro Thr Pro Leu His Leu Ala Ala Tyr Arg Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Lys Asp Leu Leu Gly Phe Thr Pro Val His Leu Ala Ala Trp Leu 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Arg Asp Arg Thr Gly Glu Thr Pro Leu His Leu Ala Ala Ala 
            100                 105                 110         


Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  25
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D14

<400>  25

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Leu Asp Val Arg Gly Ser Thr Pro Leu His Leu Ala Ala Phe Lys Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Lys Asp Leu Leu Gly Phe Thr Pro Val His Leu Ala Ala Trp Leu 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Gly Asp Arg Thr Gly Glu Thr Pro Leu His Leu Ala Ala Ala 
            100                 105                 110         


Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  26
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D1

<400>  26

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Leu Asp Val Arg Gly Ser Thr Pro Leu His Leu Ala Ala Phe Lys Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Lys Asp Leu Leu Gly Phe Thr Pro Val His Leu Ala Ala Trp Leu 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Pro Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Arg Asp Arg Thr Gly Glu Thr Pro Leu His Leu Ala Ala Ala 
            100                 105                 110         


Ile Gly His Leu Glu Ile Val Glu Ile Leu Leu Lys Tyr Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  27
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D2

<400>  27

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Leu Asp Val Arg Gly Ser Thr Pro Leu His Leu Ala Ala Phe Lys Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Lys Asp Leu Leu Gly Phe Thr Pro Val His Leu Ala Ala Trp Leu 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Arg Asp Arg Thr Gly Glu Thr Pro Leu His Leu Ala Ala Ala 
            100                 105                 110         


Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  28
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D4

<400>  28

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Gly Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Leu Asp Val Arg Gly Ser Thr Pro Leu His Leu Ala Ala Phe Lys Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Lys Asp Leu Leu Gly Phe Thr Pro Val His Leu Ala Ala Trp Leu 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Arg Asp Arg Thr Gly Glu Thr Pro Leu His Leu Ala Ala Ala 
            100                 105                 110         


Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  29
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D12

<400>  29

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val His Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Leu Asp Val Arg Gly Ser Thr Pro Leu His Leu Ala Ala Phe Lys Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Lys Asp Leu Leu Gly Phe Thr Pro Val His Leu Ala Ala Trp Leu 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Arg Asp Arg Thr Gly Glu Thr Pro Leu His Leu Ala Ala Ala 
            100                 105                 110         


Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  30
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D5

<400>  30

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Leu Asp Val Arg Gly Ser Thr Pro Leu His Leu Ala Ala Phe Lys Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asp 
    50                  55                  60                  


Ala Lys Asp Leu Leu Gly Phe Thr Pro Val His Leu Ala Ala Trp Leu 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Arg Asp Arg Thr Gly Glu Thr Pro Leu His Leu Ala Ala Ala 
            100                 105                 110         


Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Ser Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  31
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D11

<400>  31

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Gly Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Leu Asp Val Arg Gly Ser Thr Pro Leu His Leu Ala Ala Phe Lys Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Lys Asp Leu Leu Gly Phe Thr Pro Val His Leu Ala Ala Trp Leu 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Arg Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Arg Asp Arg Thr Gly Glu Thr Pro Leu His Leu Ala Ala Ala 
            100                 105                 110         


Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  32
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1.4E T10-2

<400>  32

Gly Ser Asp Leu Gly Gly Leu Leu Leu Glu Ala Ala Gln Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val His Ile Leu Met Ala Asn Gly Ala Asp Val Asn Thr 
            20                  25                  30          


Thr Asp His Leu Gly Val Thr Pro Leu His Leu Ala Ala Val Leu Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Gln His Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Tyr Asp Ile Leu Gly Arg Thr Pro Leu His Leu Ala Ala Trp Lys 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Gln Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Asp Asp Thr Ser Gly Thr Thr Pro Leu His Leu Ala Ala Ala 
            100                 105                 110         


Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Gln Tyr Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Ile Phe Gly Thr Thr Ala Ser Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  33
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1.4E C3

<400>  33

Gly Ser Asp Leu Gly Glu Leu Leu Leu Glu Ala Ala Gln Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val His Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Thr Asn His Leu Gly Val Thr Pro Leu His Leu Ala Ala Val Leu Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Gln His Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Ile Asp Ile Leu Gly Arg Thr Pro Leu His Leu Ala Ala Trp Lys 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Gln His Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Asp Asp Thr Ser Gly Thr Thr Pro Leu His Leu Ala Ala Gly 
            100                 105                 110         


Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Gln His Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Ile Asn Gly Thr Thr Ala Ser Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
145                 150                 155                 


<210>  34
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLD-1

<400>  34

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Val Asp Arg Ala Gly Thr Thr Pro Leu His Leu Ala Ala His Gly Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Arg Asp Leu Leu Gly Arg Thr Pro Leu His Leu Ala Ala Trp Arg 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Ser Asp Pro Leu Gly Ile Thr Pro Leu His Leu Ala Ala Ala 
            100                 105                 110         


Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser Glu 
145                 150                 155                 160 


Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Ala Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
            180                 185                 190         


Asp Asp Gly Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
        195                 200                 205             


Leu Asp Thr His Gly Val Thr Pro Leu His Leu Ala Ala Trp Arg Gly 
    210                 215                 220                 


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
225                 230                 235                 240 


Ala Gly Asp Val Leu Gly Arg Thr Pro Leu His Leu Ala Ala Thr Phe 
                245                 250                 255     


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
            260                 265                 270         


Asn Ala Val Asp Thr Val Gly Val Thr Pro Leu His Leu Ala Ala Gly 
        275                 280                 285             


Gln Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
    290                 295                 300                 


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
305                 310                 315                 320 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
                325                 330                 335 


<210>  35
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLD-2

<400>  35

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Ile Asp Ala Leu Gly Val Thr Pro Leu His Leu Ala Ala Trp Val Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Val Asp Val Leu Gly Trp Thr Pro Leu His Leu Ala Ala Trp Lys 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Met Asp Asn Arg Gly Pro Thr Pro Leu His Leu Ala Ala Val 
            100                 105                 110         


Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser Glu 
145                 150                 155                 160 


Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Ala Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
            180                 185                 190         


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
        195                 200                 205             


Tyr Asp Ala Arg Gly Val Thr Pro Leu His Leu Ala Ala Phe Ser Gly 
    210                 215                 220                 


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
225                 230                 235                 240 


Ala Ile Asp Val Ile Gly Met Thr Pro Leu His Leu Ala Ala Trp Ile 
                245                 250                 255     


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
            260                 265                 270         


Asn Ala Val Asp Arg Ser Gly Asn Thr Pro Leu His Leu Ala Ala Trp 
        275                 280                 285             


Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
    290                 295                 300                 


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
305                 310                 315                 320 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
                325                 330                 335 


<210>  36
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLD-3

<400>  36

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Asp Asp Arg Ile Gly Met Thr Pro Leu His Leu Ala Ala Ile Gly Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Asp Asp Val His Gly Arg Thr Pro Leu His Leu Ala Ala Gly Arg 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu His Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Pro Asp Arg Trp Gly Arg Thr Pro Leu His Leu Ala Ala His His Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Ser 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser Glu Phe Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser 
                165                 170                 175     


Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
            180                 185                 190         


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Gln Asp 
        195                 200                 205             


Tyr Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Trp Leu Gly His Leu 
    210                 215                 220                 


Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Gly 
225                 230                 235                 240 


Asp Leu Leu Gly Arg Thr Pro Leu His Leu Ala Ala Trp Phe Gly His 
                245                 250                 255     


Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
            260                 265                 270         


Val Asp Thr Met Gly Glu Thr Pro Leu His Leu Ala Ala Gly Met Gly 
        275                 280                 285             


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    290                 295                 300                 


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
305                 310                 315                 320 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
                325                 330             


<210>  37
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLD-4

<400>  37

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Asp Asp Arg Ile Gly Met Thr Pro Leu His Leu Ala Ala Ile Gly Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Asp Asp Val His Gly Arg Thr Pro Leu His Leu Ala Ala Gly Arg 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu His Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Pro Asp Arg Trp Gly Arg Thr Pro Leu His Leu Ala Ala His His Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser Glu Phe Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser 
                165                 170                 175     


Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
            180                 185                 190         


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Thr Asp 
        195                 200                 205             


His Leu Gly Val Thr Pro Leu His Leu Ala Ala Val Leu Gly His Leu 
    210                 215                 220                 


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Tyr 
225                 230                 235                 240 


Asp Ile Leu Gly Arg Thr Pro Leu His Leu Ala Ala Trp Arg Gly His 
                245                 250                 255     


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
            260                 265                 270         


Asp Asp Thr Ser Gly Thr Thr Pro Leu His Leu Ala Ala Gly Glu Gly 
        275                 280                 285             


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
    290                 295                 300                 


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
305                 310                 315                 320 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
                325                 330             


<210>  38
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLD-5

<400>  38

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Asp Asp Arg Ile Gly Met Thr Pro Leu His Leu Ala Ala Ile Gly Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Asp Asp Val His Gly Arg Thr Pro Leu His Leu Ala Ala Gly Arg 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
            100                 105                 110         


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser Glu Phe 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
    130                 135                 140                 


Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp 
145                 150                 155                 160 


Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Leu 
                165                 170                 175     


Asp Thr His Gly Val Thr Pro Leu His Leu Ala Ala Trp Arg Gly His 
            180                 185                 190         


Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala 
        195                 200                 205             


Gly Asp Val Leu Gly Arg Thr Pro Leu His Leu Ala Ala Thr Phe Gly 
    210                 215                 220                 


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Ile Asn 
225                 230                 235                 240 


Ala Val Asp Thr Val Gly Val Thr Pro Leu His Leu Ala Ala Gly Gln 
                245                 250                 255     


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
            260                 265                 270         


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
        275                 280                 285             


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
    290                 295                 300         


<210>  39
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLD-6

<400>  39

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Asp Asp Arg Ile Gly Met Thr Pro Leu His Leu Ala Ala Ile Gly Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Asp Asp Val His Gly Arg Thr Pro Leu His Leu Ala Ala Gly Arg 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu His Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Pro Asp Arg Trp Gly Arg Thr Pro Leu His Leu Ala Ala His His Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser Glu Phe Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser 
                165                 170                 175     


Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
            180                 185                 190         


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
        195                 200                 205             


Thr Phe Gly Glu Thr Pro Leu His Leu Ala Ala Trp Lys Gly His Leu 
    210                 215                 220                 


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Ser 
225                 230                 235                 240 


Asp Leu Leu Gly Arg Thr Pro Leu His Leu Ala Ala Trp Arg Gly His 
                245                 250                 255     


Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala 
            260                 265                 270         


Ser Asp Thr Gly Gly Tyr Thr Pro Leu His Leu Ala Ala Ala Leu Gly 
        275                 280                 285             


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    290                 295                 300                 


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
305                 310                 315                 320 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
                325                 330             


<210>  40
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLD-7

<400>  40

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Asp Asp Arg Ile Gly Met Thr Pro Leu His Leu Ala Ala Ile Gly Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Asp Asp Val His Gly Arg Thr Pro Leu His Leu Ala Ala Gly Arg 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu His Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Pro Asp Arg Trp Gly Arg Thr Pro Leu His Leu Ala Ala His His Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser Glu Phe Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
                165                 170                 175     


Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
            180                 185                 190         


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Val Asp 
        195                 200                 205             


Arg Ala Gly Thr Thr Pro Leu His Leu Ala Ala His Gly Gly His Leu 
    210                 215                 220                 


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Arg 
225                 230                 235                 240 


Asp Leu Leu Gly Arg Thr Pro Leu His Leu Ala Ala Trp Arg Gly His 
                245                 250                 255     


Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
            260                 265                 270         


Ser Asp Pro Leu Gly Ile Thr Pro Leu His Leu Ala Ala Ala Thr Gly 
        275                 280                 285             


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    290                 295                 300                 


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
305                 310                 315                 320 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
                325                 330             


<210>  41
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLD-10

<400>  41

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Asp Asp Arg Ile Gly Met Thr Pro Leu His Leu Ala Ala Ile Gly Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Asp Asp Val His Gly Arg Thr Pro Leu His Leu Ala Ala Gly Arg 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu His Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Pro Asp Arg Trp Gly Arg Thr Pro Leu His Leu Ala Ala His His Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser Glu Phe Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
                165                 170                 175     


Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
            180                 185                 190         


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Leu Asp 
        195                 200                 205             


Thr His Gly Val Thr Pro Leu His Leu Ala Ala Trp Arg Gly His Leu 
    210                 215                 220                 


Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Gly 
225                 230                 235                 240 


Asp Val Leu Gly Arg Thr Pro Leu His Leu Ala Ala Thr Phe Gly His 
                245                 250                 255     


Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Ile Asn Ala 
            260                 265                 270         


Val Asp Thr Val Gly Val Thr Pro Leu His Leu Ala Ala Gly Gln Gly 
        275                 280                 285             


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
    290                 295                 300                 


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
305                 310                 315                 320 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
                325                 330             


<210>  42
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLD-11

<400>  42

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Asp Asp Arg Ile Gly Met Thr Pro Leu His Leu Ala Ala Ile Gly Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Asp Asp Val His Gly Arg Thr Pro Leu His Leu Ala Ala Gly Arg 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu His Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Pro Asp Arg Trp Gly Arg Thr Pro Leu His Leu Ala Ala His His Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser Glu Phe Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser 
                165                 170                 175     


Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
            180                 185                 190         


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Tyr Asp 
        195                 200                 205             


Ala Arg Gly Val Thr Pro Leu His Leu Ala Ala Phe Ser Gly His Leu 
    210                 215                 220                 


Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Ile 
225                 230                 235                 240 


Asp Val Ile Gly Met Thr Pro Leu His Leu Ala Ala Trp Ile Gly His 
                245                 250                 255     


Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
            260                 265                 270         


Val Asp Arg Ser Gly Asn Thr Pro Leu His Leu Ala Ala Trp Leu Gly 
        275                 280                 285             


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
    290                 295                 300                 


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
305                 310                 315                 320 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
                325                 330             


<210>  43
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLD-12

<400>  43

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Asp Asp Arg Ile Gly Met Thr Pro Leu His Leu Ala Ala Ile Gly Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Asp Asp Val His Gly Arg Thr Pro Leu His Leu Ala Ala Gly Arg 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu His Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Pro Asp Arg Trp Gly Arg Thr Pro Leu His Leu Ala Ala His His Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser Glu Phe Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser 
                165                 170                 175     


Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
            180                 185                 190         


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Thr Asp 
        195                 200                 205             


His Leu Gly Val Thr Pro Leu His Leu Ala Ala Val Leu Gly His Leu 
    210                 215                 220                 


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Tyr 
225                 230                 235                 240 


Asp Ile Leu Gly Arg Thr Pro Leu His Leu Ala Ala Trp Arg Gly His 
                245                 250                 255     


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
            260                 265                 270         


Val Asp Thr Met Gly Glu Thr Pro Leu His Leu Ala Ala Gly Met Gly 
        275                 280                 285             


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    290                 295                 300                 


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
305                 310                 315                 320 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
                325                 330             


<210>  44
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ran2-D-F

<400>  44
catgtgcatt atctgggatc cgacctgg                                          28


<210>  45
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ran2-D-R

<400>  45
taacaggccg caagctttta cga                                               23


<210>  46
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker-BSAi-D-F

<400>  46
ttagctggtc tctggaggga gcggaggcgg agggagcgct agcgacctgg gtaagaaact       60

gctg                                                                    64


<210>  47
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker-BSAi-D-R

<400>  47
gaaatcctgc aatcgagctc ggaattcgga ggcggaggga gcggaggcgg agtgagacct       60

tagct                                                                   65


<210>  48
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GGGGS)x3 Linker

<400>  48

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  49
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U3D16

<400>  49

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Asp Asp Arg Ile Gly Met Thr Pro Leu His Leu Ala Ala Ile Gly Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Asp Asp Val His Gly Arg Thr Pro Leu His Leu Ala Ala Gly Arg 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu His Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Pro Asp Arg Trp Gly Arg Thr Pro Leu His Leu Ala Ala His His Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Ser 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp Leu 
                165                 170                 175     


Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val 
            180                 185                 190         


Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Ala Asp Arg Tyr 
        195                 200                 205             


Gly Pro Thr Pro Leu His Leu Ala Ala Tyr Arg Gly His Leu Glu Ile 
    210                 215                 220                 


Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Lys Asp Val 
225                 230                 235                 240 


Leu Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ile Gly His Leu Glu 
                245                 250                 255     


Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Arg Asp 
            260                 265                 270         


Arg Thr Gly Glu Thr Pro Leu His Leu Ala Ala Ala Ile Gly His Leu 
        275                 280                 285             


Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Gln 
    290                 295                 300                 


Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn 
305                 310                 315                 320 


Glu Asp Leu Ala Glu Ile Leu Gln Ser Ser Ser 
                325                 330     


