                               SEQUENCE LISTING

<110> DECIPHERA PHARMACEUTICALS, LLC
 
<120> PHENYLAMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF 
      USE THEREOF

<130> DCP-079WO

<140>
<141>

<150> 62/711,730
<151> 2019-10-07

<150> 62/911,728
<151> 2019-10-07

<150> 62/846,258
<151> 2019-05-10

<150> 62/846,251
<151> 2019-05-10

<160> 6     

<170> PatentIn version 3.5

<210> 1
<211> 344
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1
Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr 
1               5                   10                  15      


Thr Glu Asn Leu Tyr Phe Gln Gly Ala Met Asp Pro Phe Phe Met Glu 
            20                  25                  30          


Pro Gly Arg Gly Gly Thr Glu Thr Val Gly Lys Phe Glu Phe Ser Arg 
        35                  40                  45              


Lys Asp Leu Ile Gly His Gly Ala Phe Ala Val Val Phe Lys Gly Arg 
    50                  55                  60                  


His Arg Glu Lys His Asp Leu Glu Val Ala Val Lys Cys Ile Asn Lys 
65                  70                  75                  80  


Lys Asn Leu Ala Lys Ser Gln Thr Leu Leu Gly Lys Glu Ile Lys Ile 
                85                  90                  95      


Leu Lys Glu Leu Lys His Glu Asn Ile Val Ala Leu Tyr Asp Phe Gln 
            100                 105                 110         


Glu Met Ala Asn Ser Val Tyr Leu Val Met Glu Tyr Cys Asn Gly Gly 
        115                 120                 125             


Asp Leu Ala Asp Tyr Leu His Ala Met Arg Thr Leu Ser Glu Asp Thr 
    130                 135                 140                 


Ile Arg Leu Phe Leu Gln Gln Ile Ala Gly Ala Met Arg Leu Leu His 
145                 150                 155                 160 


Ser Lys Gly Ile Ile His Arg Asp Leu Lys Pro Gln Asn Ile Leu Leu 
                165                 170                 175     


Ser Asn Pro Ala Gly Arg Arg Ala Asn Pro Asn Ser Ile Arg Val Lys 
            180                 185                 190         


Ile Ala Asp Phe Gly Phe Ala Arg Tyr Leu Gln Ser Asn Met Met Ala 
        195                 200                 205             


Ala Thr Leu Cys Gly Ser Pro Met Tyr Met Ala Pro Glu Val Ile Met 
    210                 215                 220                 


Ser Gln His Tyr Asp Gly Lys Ala Asp Leu Trp Ser Ile Gly Thr Ile 
225                 230                 235                 240 


Val Tyr Gln Cys Leu Thr Gly Lys Ala Pro Phe Gln Ala Ser Ser Pro 
                245                 250                 255     


Gln Asp Leu Arg Leu Phe Tyr Glu Lys Asn Lys Thr Leu Val Pro Thr 
            260                 265                 270         


Ile Pro Arg Glu Thr Ser Ala Pro Leu Arg Gln Leu Leu Leu Ala Leu 
        275                 280                 285             


Leu Gln Arg Asn His Lys Asp Arg Met Asp Phe Asp Glu Phe Phe His 
    290                 295                 300                 


His Pro Phe Leu Asp Ala Ser Pro Ser Val Arg Lys Ser Pro Pro Val 
305                 310                 315                 320 


Pro Val Pro Ser Tyr Pro Ser Ser Gly Ser Gly Ser Ser Ser Ser Ser 
                325                 330                 335     


Ser Ser Thr Ser His Leu Ala Ser 
            340                 


<210> 2
<211> 283
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      ULK1 sequence"

<400> 2
Met Glu Pro Gly Arg Gly Gly Thr Glu Thr Val Gly Lys Phe Glu Phe 
1               5                   10                  15      


Ser Arg Lys Asp Leu Ile Gly His Gly Ala Phe Ala Val Val Phe Lys 
            20                  25                  30          


Gly Arg His Arg Ala Ala His Asp Leu Glu Val Ala Val Lys Cys Ile 
        35                  40                  45              


Asn Lys Lys Asn Leu Ala Lys Ser Gln Thr Leu Leu Gly Lys Glu Ile 
    50                  55                  60                  


Lys Ile Leu Lys Glu Leu Lys His Glu Asn Ile Val Ala Leu Tyr Asp 
65                  70                  75                  80  


Phe Gln Glu Met Ala Asn Ser Val Tyr Leu Val Met Glu Tyr Cys Asn 
                85                  90                  95      


Gly Gly Asp Leu Ala Asp Tyr Leu His Ala Met Arg Thr Leu Ser Glu 
            100                 105                 110         


Asp Thr Ile Arg Leu Phe Leu Gln Gln Ile Ala Gly Ala Met Arg Leu 
        115                 120                 125             


Leu His Ser Lys Gly Ile Ile His Arg Asp Leu Lys Pro Gln Asn Ile 
    130                 135                 140                 


Leu Leu Ser Asn Pro Ala Gly Arg Arg Ala Asn Pro Asn Ser Ile Arg 
145                 150                 155                 160 


Val Lys Ile Ala Asp Phe Gly Phe Ala Arg Tyr Leu Gln Ser Asn Met 
                165                 170                 175     


Met Ala Ala Thr Leu Cys Gly Ser Pro Met Tyr Met Ala Pro Glu Val 
            180                 185                 190         


Ile Met Ser Gln His Tyr Asp Gly Lys Ala Asp Leu Trp Ser Ile Gly 
        195                 200                 205             


Thr Ile Val Tyr Gln Cys Leu Thr Gly Lys Ala Pro Phe Gln Ala Ser 
    210                 215                 220                 


Ser Pro Gln Asp Leu Arg Leu Phe Tyr Glu Lys Asn Lys Thr Leu Val 
225                 230                 235                 240 


Pro Thr Ile Pro Arg Glu Thr Ser Ala Pro Leu Arg Gln Leu Leu Leu 
                245                 250                 255     


Ala Leu Leu Gln Arg Asn His Lys Asp Arg Met Asp Phe Asp Glu Phe 
            260                 265                 270         


Phe His His Pro Phe Leu Asp Ala Ser Pro Ser 
        275                 280             


<210> 3
<211> 542
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Glu Phe Met Glu Val Val Gly Asp Phe Glu Tyr Ser 
225                 230                 235                 240 


Lys Arg Asp Leu Val Gly His Gly Ala Phe Ala Val Val Phe Arg Gly 
                245                 250                 255     


Arg His Arg Gln Lys Thr Asp Trp Glu Val Ala Ile Lys Ser Ile Asn 
            260                 265                 270         


Lys Lys Asn Leu Ser Lys Ser Gln Ile Leu Leu Gly Lys Glu Ile Lys 
        275                 280                 285             


Ile Leu Lys Glu Leu Gln His Glu Asn Ile Val Ala Leu Tyr Asp Val 
    290                 295                 300                 


Gln Glu Leu Pro Asn Ser Val Phe Leu Val Met Glu Tyr Cys Asn Gly 
305                 310                 315                 320 


Gly Asp Leu Ala Asp Tyr Leu Gln Ala Lys Gly Thr Leu Ser Glu Asp 
                325                 330                 335     


Thr Ile Arg Val Phe Leu His Gln Ile Ala Ala Ala Met Arg Ile Leu 
            340                 345                 350         


His Ser Lys Gly Ile Ile His Arg Asp Leu Lys Pro Gln Asn Ile Leu 
        355                 360                 365             


Leu Ser Tyr Ala Asn Arg Arg Lys Ser Ser Val Ser Gly Ile Arg Ile 
    370                 375                 380                 


Lys Ile Ala Asp Phe Gly Phe Ala Arg Tyr Leu His Ser Asn Met Met 
385                 390                 395                 400 


Ala Ala Thr Leu Cys Gly Ser Pro Met Tyr Met Ala Pro Glu Val Ile 
                405                 410                 415     


Met Ser Gln His Tyr Asp Ala Lys Ala Asp Leu Trp Ser Ile Gly Thr 
            420                 425                 430         


Val Ile Tyr Gln Cys Leu Val Gly Lys Pro Pro Phe Gln Ala Asn Ser 
        435                 440                 445             


Pro Gln Asp Leu Arg Met Phe Tyr Glu Lys Asn Arg Ser Leu Met Pro 
    450                 455                 460                 


Ser Ile Pro Arg Glu Thr Ser Pro Tyr Leu Ala Asn Leu Leu Leu Gly 
465                 470                 475                 480 


Leu Leu Gln Arg Asn Gln Lys Asp Arg Met Asp Phe Glu Ala Phe Phe 
                485                 490                 495     


Ser His Pro Phe Leu Glu Gln Gly Pro Val Lys Lys Ser Cys Pro Val 
            500                 505                 510         


Pro Val Pro Met Tyr Ser Gly Ser Val Ser Gly Ser Ser Cys Gly Ser 
        515                 520                 525             


Ser Pro Ser Cys Arg Phe Ala Ser His His His His His His 
    530                 535                 540         


<210> 4
<211> 1795
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      LRRK2 sequence"

<400> 4
Met Ala Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


His Asn Gln Thr Ser Leu Tyr Lys Lys Ala Gly Thr Met His Ser Asp 
225                 230                 235                 240 


Ser Ile Ser Ser Leu Ala Ser Glu Arg Glu Tyr Ile Thr Ser Leu Asp 
                245                 250                 255     


Leu Ser Ala Asn Glu Leu Arg Asp Ile Asp Ala Leu Ser Gln Lys Cys 
            260                 265                 270         


Cys Ile Ser Val His Leu Glu His Leu Glu Lys Leu Glu Leu His Gln 
        275                 280                 285             


Asn Ala Leu Thr Ser Phe Pro Gln Gln Leu Cys Glu Thr Leu Lys Ser 
    290                 295                 300                 


Leu Thr His Leu Asp Leu His Ser Asn Lys Phe Thr Ser Phe Pro Ser 
305                 310                 315                 320 


Tyr Leu Leu Lys Met Ser Cys Ile Ala Asn Leu Asp Val Ser Arg Asn 
                325                 330                 335     


Asp Ile Gly Pro Ser Val Val Leu Asp Pro Thr Val Lys Cys Pro Thr 
            340                 345                 350         


Leu Lys Gln Phe Asn Leu Ser Tyr Asn Gln Leu Ser Phe Val Pro Glu 
        355                 360                 365             


Asn Leu Thr Asp Val Val Glu Lys Leu Glu Gln Leu Ile Leu Glu Gly 
    370                 375                 380                 


Asn Lys Ile Ser Gly Ile Cys Ser Pro Leu Arg Leu Lys Glu Leu Lys 
385                 390                 395                 400 


Ile Leu Asn Leu Ser Lys Asn His Ile Ser Ser Leu Ser Glu Asn Phe 
                405                 410                 415     


Leu Glu Ala Cys Pro Lys Val Glu Ser Phe Ser Ala Arg Met Asn Phe 
            420                 425                 430         


Leu Ala Ala Met Pro Phe Leu Pro Pro Ser Met Thr Ile Leu Lys Leu 
        435                 440                 445             


Ser Gln Asn Lys Phe Ser Cys Ile Pro Glu Ala Ile Leu Asn Leu Pro 
    450                 455                 460                 


His Leu Arg Ser Leu Asp Met Ser Ser Asn Asp Ile Gln Tyr Leu Pro 
465                 470                 475                 480 


Gly Pro Ala His Trp Lys Ser Leu Asn Leu Arg Glu Leu Leu Phe Ser 
                485                 490                 495     


His Asn Gln Ile Ser Ile Leu Asp Leu Ser Glu Lys Ala Tyr Leu Trp 
            500                 505                 510         


Ser Arg Val Glu Lys Leu His Leu Ser His Asn Lys Leu Lys Glu Ile 
        515                 520                 525             


Pro Pro Glu Ile Gly Cys Leu Glu Asn Leu Thr Ser Leu Asp Val Ser 
    530                 535                 540                 


Tyr Asn Leu Glu Leu Arg Ser Phe Pro Asn Glu Met Gly Lys Leu Ser 
545                 550                 555                 560 


Lys Ile Trp Asp Leu Pro Leu Asp Glu Leu His Leu Asn Phe Asp Phe 
                565                 570                 575     


Lys His Ile Gly Cys Lys Ala Lys Asp Ile Ile Arg Phe Leu Gln Gln 
            580                 585                 590         


Arg Leu Lys Lys Ala Val Pro Tyr Asn Arg Met Lys Leu Met Ile Val 
        595                 600                 605             


Gly Asn Thr Gly Ser Gly Lys Thr Thr Leu Leu Gln Gln Leu Met Lys 
    610                 615                 620                 


Thr Lys Lys Ser Asp Leu Gly Met Gln Ser Ala Thr Val Gly Ile Asp 
625                 630                 635                 640 


Val Lys Asp Trp Pro Ile Gln Ile Arg Asp Lys Arg Lys Arg Asp Leu 
                645                 650                 655     


Val Leu Asn Val Trp Asp Phe Ala Gly Arg Glu Glu Phe Tyr Ser Thr 
            660                 665                 670         


His Pro His Phe Met Thr Gln Arg Ala Leu Tyr Leu Ala Val Tyr Asp 
        675                 680                 685             


Leu Ser Lys Gly Gln Ala Glu Val Asp Ala Met Lys Pro Trp Leu Phe 
    690                 695                 700                 


Asn Ile Lys Ala Arg Ala Ser Ser Ser Pro Val Ile Leu Val Gly Thr 
705                 710                 715                 720 


His Leu Asp Val Ser Asp Glu Lys Gln Arg Lys Ala Cys Met Ser Lys 
                725                 730                 735     


Ile Thr Lys Glu Leu Leu Asn Lys Arg Gly Phe Pro Ala Ile Arg Asp 
            740                 745                 750         


Tyr His Phe Val Asn Ala Thr Glu Glu Ser Asp Ala Leu Ala Lys Leu 
        755                 760                 765             


Arg Lys Thr Ile Ile Asn Glu Ser Leu Asn Phe Lys Ile Arg Asp Gln 
    770                 775                 780                 


Leu Val Val Gly Gln Leu Ile Pro Asp Cys Tyr Val Glu Leu Glu Lys 
785                 790                 795                 800 


Ile Ile Leu Ser Glu Arg Lys Asn Val Pro Ile Glu Phe Pro Val Ile 
                805                 810                 815     


Asp Arg Lys Arg Leu Leu Gln Leu Val Arg Glu Asn Gln Leu Gln Leu 
            820                 825                 830         


Asp Glu Asn Glu Leu Pro His Ala Val His Phe Leu Asn Glu Ser Gly 
        835                 840                 845             


Val Leu Leu His Phe Gln Asp Pro Ala Leu Gln Leu Ser Asp Leu Tyr 
    850                 855                 860                 


Phe Val Glu Pro Lys Trp Leu Cys Lys Ile Met Ala Gln Ile Leu Thr 
865                 870                 875                 880 


Val Lys Val Glu Gly Cys Pro Lys His Pro Lys Gly Ile Ile Ser Arg 
                885                 890                 895     


Arg Asp Val Glu Lys Phe Leu Ser Lys Lys Arg Lys Phe Pro Lys Asn 
            900                 905                 910         


Tyr Met Ser Gln Tyr Phe Lys Leu Leu Glu Lys Phe Gln Ile Ala Leu 
        915                 920                 925             


Pro Ile Gly Glu Glu Tyr Leu Leu Val Pro Ser Ser Leu Ser Asp His 
    930                 935                 940                 


Arg Pro Val Ile Glu Leu Pro His Cys Glu Asn Ser Glu Ile Ile Ile 
945                 950                 955                 960 


Arg Leu Tyr Glu Met Pro Tyr Phe Pro Met Gly Phe Trp Ser Arg Leu 
                965                 970                 975     


Ile Asn Arg Leu Leu Glu Ile Ser Pro Tyr Met Leu Ser Gly Arg Glu 
            980                 985                 990         


Arg Ala Leu Arg Pro Asn Arg Met  Tyr Trp Arg Gln Gly  Ile Tyr Leu 
        995                 1000                 1005             


Asn Trp  Ser Pro Glu Ala Tyr  Cys Leu Val Gly Ser  Glu Val Leu 
    1010                 1015                 1020             


Asp Asn  His Pro Glu Ser Phe  Leu Lys Ile Thr Val  Pro Ser Cys 
    1025                 1030                 1035             


Arg Lys  Gly Cys Ile Leu Leu  Gly Gln Val Val Asp  His Ile Asp 
    1040                 1045                 1050             


Ser Leu  Met Glu Glu Trp Phe  Pro Gly Leu Leu Glu  Ile Asp Ile 
    1055                 1060                 1065             


Cys Gly  Glu Gly Glu Thr Leu  Leu Lys Lys Trp Ala  Leu Tyr Ser 
    1070                 1075                 1080             


Phe Asn  Asp Gly Glu Glu His  Gln Lys Ile Leu Leu  Asp Asp Leu 
    1085                 1090                 1095             


Met Lys  Lys Ala Glu Glu Gly  Asp Leu Leu Val Asn  Pro Asp Gln 
    1100                 1105                 1110             


Pro Arg  Leu Thr Ile Pro Ile  Ser Gln Ile Ala Pro  Asp Leu Ile 
    1115                 1120                 1125             


Leu Ala  Asp Leu Pro Arg Asn  Ile Met Leu Asn Asn  Asp Glu Leu 
    1130                 1135                 1140             


Glu Phe  Glu Gln Ala Pro Glu  Phe Leu Leu Gly Asp  Gly Ser Phe 
    1145                 1150                 1155             


Gly Ser  Val Tyr Arg Ala Ala  Tyr Glu Gly Glu Glu  Val Ala Val 
    1160                 1165                 1170             


Lys Ile  Phe Asn Lys His Thr  Ser Leu Arg Leu Leu  Arg Gln Glu 
    1175                 1180                 1185             


Leu Val  Val Leu Cys His Leu  His His Pro Ser Leu  Ile Ser Leu 
    1190                 1195                 1200             


Leu Ala  Ala Gly Ile Arg Pro  Arg Met Leu Val Met  Glu Leu Ala 
    1205                 1210                 1215             


Ser Lys  Gly Ser Leu Asp Arg  Leu Leu Gln Gln Asp  Lys Ala Ser 
    1220                 1225                 1230             


Leu Thr  Arg Thr Leu Gln His  Arg Ile Ala Leu His  Val Ala Asp 
    1235                 1240                 1245             


Gly Leu  Arg Tyr Leu His Ser  Ala Met Ile Ile Tyr  Arg Asp Leu 
    1250                 1255                 1260             


Lys Pro  His Asn Val Leu Leu  Phe Thr Leu Tyr Pro  Asn Ala Ala 
    1265                 1270                 1275             


Ile Ile  Ala Lys Ile Ala Asp  Tyr Gly Ile Ala Gln  Tyr Cys Cys 
    1280                 1285                 1290             


Arg Met  Gly Ile Lys Thr Ser  Glu Gly Thr Pro Gly  Phe Arg Ala 
    1295                 1300                 1305             


Pro Glu  Val Ala Arg Gly Asn  Val Ile Tyr Asn Gln  Gln Ala Asp 
    1310                 1315                 1320             


Val Tyr  Ser Phe Gly Leu Leu  Leu Tyr Asp Ile Leu  Thr Thr Gly 
    1325                 1330                 1335             


Gly Arg  Ile Val Glu Gly Leu  Lys Phe Pro Asn Glu  Phe Asp Glu 
    1340                 1345                 1350             


Leu Glu  Ile Gln Gly Lys Leu  Pro Asp Pro Val Lys  Glu Tyr Gly 
    1355                 1360                 1365             


Cys Ala  Pro Trp Pro Met Val  Glu Lys Leu Ile Lys  Gln Cys Leu 
    1370                 1375                 1380             


Lys Glu  Asn Pro Gln Glu Arg  Pro Thr Ser Ala Gln  Val Phe Asp 
    1385                 1390                 1395             


Ile Leu  Asn Ser Ala Glu Leu  Val Cys Leu Thr Arg  Arg Ile Leu 
    1400                 1405                 1410             


Leu Pro  Lys Asn Val Ile Val  Glu Cys Met Val Ala  Thr His His 
    1415                 1420                 1425             


Asn Ser  Arg Asn Ala Ser Ile  Trp Leu Gly Cys Gly  His Thr Asp 
    1430                 1435                 1440             


Arg Gly  Gln Leu Ser Phe Leu  Asp Leu Asn Thr Glu  Gly Tyr Thr 
    1445                 1450                 1455             


Ser Glu  Glu Val Ala Asp Ser  Arg Ile Leu Cys Leu  Ala Leu Val 
    1460                 1465                 1470             


His Leu  Pro Val Glu Lys Glu  Ser Trp Ile Val Ser  Gly Thr Gln 
    1475                 1480                 1485             


Ser Gly  Thr Leu Leu Val Ile  Asn Thr Glu Asp Gly  Lys Lys Arg 
    1490                 1495                 1500             


His Thr  Leu Glu Lys Met Thr  Asp Ser Val Thr Cys  Leu Tyr Cys 
    1505                 1510                 1515             


Asn Ser  Phe Ser Lys Gln Ser  Lys Gln Lys Asn Phe  Leu Leu Val 
    1520                 1525                 1530             


Gly Thr  Ala Asp Gly Lys Leu  Ala Ile Phe Glu Asp  Lys Thr Val 
    1535                 1540                 1545             


Lys Leu  Lys Gly Ala Ala Pro  Leu Lys Ile Leu Asn  Ile Gly Asn 
    1550                 1555                 1560             


Val Ser  Thr Pro Leu Met Cys  Leu Ser Glu Ser Thr  Asn Ser Thr 
    1565                 1570                 1575             


Glu Arg  Asn Val Met Trp Gly  Gly Cys Gly Thr Lys  Ile Phe Ser 
    1580                 1585                 1590             


Phe Ser  Asn Asp Phe Thr Ile  Gln Lys Leu Ile Glu  Thr Arg Thr 
    1595                 1600                 1605             


Ser Gln  Leu Phe Ser Tyr Ala  Ala Phe Ser Asp Ser  Asn Ile Ile 
    1610                 1615                 1620             


Thr Val  Val Val Asp Thr Ala  Leu Tyr Ile Ala Lys  Gln Asn Ser 
    1625                 1630                 1635             


Pro Val  Val Glu Val Trp Asp  Lys Lys Thr Glu Lys  Leu Cys Gly 
    1640                 1645                 1650             


Leu Ile  Asp Cys Val His Phe  Leu Arg Glu Val Met  Val Lys Glu 
    1655                 1660                 1665             


Asn Lys  Glu Ser Lys His Lys  Met Ser Tyr Ser Gly  Arg Val Lys 
    1670                 1675                 1680             


Thr Leu  Cys Leu Gln Lys Asn  Thr Ala Leu Trp Ile  Gly Thr Gly 
    1685                 1690                 1695             


Gly Gly  His Ile Leu Leu Leu  Asp Leu Ser Thr Arg  Arg Leu Ile 
    1700                 1705                 1710             


Arg Val  Ile Tyr Asn Phe Cys  Asn Ser Val Arg Val  Met Met Thr 
    1715                 1720                 1725             


Ala Gln  Leu Gly Ser Leu Lys  Asn Val Met Leu Val  Leu Gly Tyr 
    1730                 1735                 1740             


Asn Arg  Lys Asn Thr Glu Gly  Thr Gln Lys Gln Lys  Glu Ile Gln 
    1745                 1750                 1755             


Ser Cys  Leu Thr Val Trp Asp  Ile Asn Leu Pro His  Glu Val Gln 
    1760                 1765                 1770             


Asn Leu  Glu Lys His Ile Glu  Val Arg Lys Glu Leu  Ala Glu Lys 
    1775                 1780                 1785             


Met Arg  Arg Thr Ser Val Glu  
    1790                 1795 


<210> 5
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 5
Tyr Ala Asn Trp Leu Ala Ala Ser Ile Tyr Leu Asp Gly Lys Lys Lys 
1               5                   10                  15      


<210> 6
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 6
Arg Leu Gly Arg Asp Lys Tyr Lys Thr Leu Arg Gln Ile Arg Gln 
1               5                   10                  15  


