                         SEQUENCE LISTING

<110>  National University of Singapore
 
<120>  STAPLED RELAXIN-3 B-CHAIN PEPTIDE ANTAGONISTS

<130>  SP101039WO

<150>  SG10201904291Y
<151>  2019-05-13

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R3 B-chain

<400>  1

Arg Ala Ala Pro Tyr Gly Val Arg Leu Cys Gly Arg Glu Phe Ile Arg 
1               5                   10                  15      


Ala Val Ile Phe Thr Cys Gly Gly Ser Arg Trp 
            20                  25          


<210>  2
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R3 B-chain (Ser)

<400>  2

Arg Ala Ala Pro Tyr Gly Val Arg Leu Ser Gly Arg Glu Phe Ile Arg 
1               5                   10                  15      


Ala Val Ile Phe Thr Ser Gly Gly Ser Arg Trp 
            20                  25          


<210>  3
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated R3 B-chain

<400>  3

Arg Leu Cys Gly Arg Glu Phe Ile Arg Ala Val Ile Phe Thr Cys Gly 
1               5                   10                  15      


Gly Cys Arg Trp 
            20  


<210>  4
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated R3 B-chain (Ser)

<400>  4

Arg Leu Ser Gly Arg Glu Phe Ile Arg Ala Val Ile Phe Thr Ser Gly 
1               5                   10                  15      


Gly Ser Arg Trp 
            20  


<210>  5
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R3 B1-22R

<400>  5

Arg Ala Ala Pro Tyr Gly Val Arg Leu Ser Gly Arg Glu Phe Ile Arg 
1               5                   10                  15      


Ala Val Ile Phe Thr Ser Arg 
            20              


<210>  6
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14s18 (Ser)


<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is (S)-2-(4-pentenyl) alanine.

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Xaa is (S)-2-(4-pentenyl) alanine.

<400>  6

Arg Ala Ala Pro Tyr Gly Val Arg Leu Ser Gly Arg Glu Xaa Ile Arg 
1               5                   10                  15      


Ala Xaa Ile Phe Thr Ser Gly Gly Ser Arg Trp 
            20                  25          


<210>  7
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated 14s18 (Ser)


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-(4-pentenyl) alanine.

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is (S)-2-(4-pentenyl) alanine.

<400>  7

Arg Leu Ser Gly Arg Glu Xaa Ile Arg Ala Xaa Ile Phe Thr Ser Gly 
1               5                   10                  15      


Gly Ser Arg Trp 
            20  


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated 14s18R


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-(4-pentenyl) alanine.

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is (S)-2-(4-pentenyl) alanine.

<400>  8

Arg Leu Cys Gly Arg Glu Xaa Ile Arg Ala Xaa Ile Phe Thr Cys Arg 
1               5                   10                  15      


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated 14s18R (Ser)


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-(4-pentenyl) alanine.

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is (S)-2-(4-pentenyl) alanine.

<400>  9

Arg Leu Ser Gly Arg Glu Xaa Ile Arg Ala Xaa Ile Phe Thr Ser Arg 
1               5                   10                  15      


<210>  10
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14s18R


<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is (S)-2-(4-pentenyl) alanine.

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Xaa is (S)-2-(4-pentenyl) alanine.

<400>  10

Arg Ala Ala Pro Tyr Gly Val Arg Leu Cys Gly Arg Glu Xaa Ile Arg 
1               5                   10                  15      


Ala Xaa Ile Phe Thr Cys Arg 
            20              


<210>  11
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14s18R (Ser)


<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is (S)-2-(4-pentenyl) alanine.

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Xaa is (S)-2-(4-pentenyl) alanine.

<400>  11

Arg Ala Ala Pro Tyr Gly Val Arg Leu Ser Gly Arg Glu Xaa Ile Arg 
1               5                   10                  15      


Ala Xaa Ile Phe Thr Ser Arg 
            20              


<210>  12
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14s21R


<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is (R)-2-(4'-pentenyl) alanine.

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is (S)-2-(7'-octenyl) alanine.

<400>  12

Arg Ala Ala Pro Tyr Gly Val Arg Leu Cys Gly Arg Glu Xaa Ile Arg 
1               5                   10                  15      


Ala Val Ile Phe Xaa Cys Arg 
            20              


<210>  13
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14s21R (Ser)


<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is (R)-2-(4'-pentenyl) alanine.

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is (S)-2-(7'-octenyl) alanine.

<400>  13

Arg Ala Ala Pro Tyr Gly Val Arg Leu Ser Gly Arg Glu Xaa Ile Arg 
1               5                   10                  15      


Ala Val Ile Phe Xaa Ser Arg 
            20              


<210>  14
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14s18


<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is (S)-2-(4-pentenyl) alanine).

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Xaa is (S)-2-(4-pentenyl) alanine).

<400>  14

Arg Ala Ala Pro Tyr Gly Val Arg Leu Cys Gly Arg Glu Xaa Ile Arg 
1               5                   10                  15      


Ala Xaa Ile Phe Thr Cys Gly Gly Ser Arg Trp 
            20                  25          


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated 14s18


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-(4-pentenyl) alanine).

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is (S)-2-(4-pentenyl) alanine).

<400>  15

Arg Leu Cys Gly Arg Glu Xaa Ile Arg Ala Xaa Ile Phe Thr Cys Gly 
1               5                   10                  15      


Gly Ser Arg Trp 
            20  


<210>  16
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-chain formula 1


<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is a cross-linked amino acid.

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is a cross-linked amino acid.

<400>  16

Arg Ala Ala Pro Tyr Gly Val Arg Leu Ser Gly Arg Glu Xaa Ile Arg 
1               5                   10                  15      


Ala Val Ile Phe Xaa Ser Arg 
            20              


<210>  17
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-chain formula 2


<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is a cross-linked amino acid.

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Xaa is a cross-linked amino acid.

<400>  17

Arg Ala Ala Pro Tyr Gly Val Arg Leu Ser Gly Arg Glu Xaa Ile Arg 
1               5                   10                  15      


Ala Xaa Ile Phe Thr Ser Arg 
            20              


