                         SEQUENCE LISTING

<110>  TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
       RAMOT AT TEL-AVIV UNIVERSITY LTD.
 
<120>  CANNABINOIDS AND USES THEREOF

<130>  TECH-RMT-P-0182-PCT

<150>  US 62/848,695
<151>  2019-05-16

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  9568
<212>  DNA
<213>  Homo sapiens

<400>  1
actagtgcct cggccgcggg agggagcgca agggcgcggg gcgcggggcg cgggcgcggg       60

cgcgagcgca gcgaaggaac gagccgggcg cggagccggg cccgggggcc tgcgagagca      120

cagcgccgcc agccagccgg ggaagagagg gcgggaccgt ccgccgccgc cccgggaccg      180

tacgccgcgc gtgtgcgtcc cagccccgcc ggccagcgca ggaggccgcc gcccgggcgc      240

agagggcagc cggtggggag gcatgccgcc gctcctggcg cccctgctct gcctggcgct      300

gctgcccgcg ctcgccgcac gaggcccgcg atgctcccag cccggtgaga cctgcctgaa      360

tggcgggaag tgtgaagcgg ccaatggcac ggaggcctgc gtctgtggcg gggccttcgt      420

gggcccgcga tgccaggacc ccaacccgtg cctcagcacc ccctgcaaga acgccgggac      480

atgccacgtg gtggaccgca gaggcgtggc agactatgcc tgcagctgtg ccctgggctt      540

ctctgggccc ctctgcctga cacccctgga caatgcctgc ctcaccaacc cctgccgcaa      600

cgggggcacc tgcgacctgc tcacgctgac ggagtacaag tgccgctgcc cgcccggctg      660

gtcagggaaa tcgtgccagc aggctgaccc gtgcgcctcc aacccctgcg ccaacggtgg      720

ccagtgcctg cccttcgagg cctcctacat ctgccactgc ccacccagct tccatggccc      780

cacctgccgg caggatgtca acgagtgtgg ccagaagccc gggctttgcc gccacggagg      840

cacctgccac aacgaggtcg gctcctaccg ctgcgtctgc cgcgccaccc acactggccc      900

caactgcgag cggccctacg tgccctgcag cccctcgccc tgccagaacg ggggcacctg      960

ccgccccacg ggcgacgtca cccacgagtg tgcctgcctg ccaggcttca ccggccagaa     1020

ctgtgaggaa aatatcgacg attgtccagg aaacaactgc aagaacgggg gtgcctgtgt     1080

ggacggcgtg aacacctaca actgccgctg cccgccagag tggacaggtc agtactgtac     1140

cgaggatgtg gacgagtgcc agctgatgcc aaatgcctgc cagaacggcg ggacctgcca     1200

caacacccac ggtggctaca actgcgtgtg tgtcaacggc tggactggtg aggactgcag     1260

cgagaacatt gatgactgtg ccagcgccgc ctgcttccac ggcgccacct gccatgaccg     1320

tgtggcctcc ttctactgcg agtgtcccca tggccgcaca ggtctgctgt gccacctcaa     1380

cgacgcatgc atcagcaacc cctgtaacga gggctccaac tgcgacacca accctgtcaa     1440

tggcaaggcc atctgcacct gcccctcggg gtacacgggc ccggcctgca gccaggacgt     1500

ggatgagtgc tcgctgggtg ccaacccctg cgagcatgcg ggcaagtgca tcaacacgct     1560

gggctccttc gagtgccagt gtctgcaggg ctacacgggc ccccgatgcg agatcgacgt     1620

caacgagtgc gtctcgaacc cgtgccagaa cgacgccacc tgcctggacc agattgggga     1680

gttccagtgc atctgcatgc ccggctacga gggtgtgcac tgcgaggtca acacagacga     1740

gtgtgccagc agcccctgcc tgcacaatgg ccgctgcctg gacaagatca atgagttcca     1800

gtgcgagtgc cccacgggct tcactgggca tctgtgccag tacgatgtgg acgagtgtgc     1860

cagcaccccc tgcaagaatg gtgccaagtg cctggacgga cccaacactt acacctgtgt     1920

gtgcacggaa gggtacacgg ggacgcactg cgaggtggac atcgatgagt gcgaccccga     1980

cccctgccac tacggctcct gcaaggacgg cgtcgccacc ttcacctgcc tctgccgccc     2040

aggctacacg ggccaccact gcgagaccaa catcaacgag tgctccagcc agccctgccg     2100

ccacgggggc acctgccagg accgcgacaa cgcctacctc tgcttctgcc tgaaggggac     2160

cacaggaccc aactgcgaga tcaacctgga tgactgtgcc agcagcccct gcgactcggg     2220

cacctgtctg gacaagatcg atggctacga gtgtgcctgt gagccgggct acacagggag     2280

catgtgtaac atcaacatcg atgagtgtgc gggcaacccc tgccacaacg ggggcacctg     2340

cgaggacggc atcaatggct tcacctgccg ctgccccgag ggctaccacg accccacctg     2400

cctgtctgag gtcaatgagt gcaacagcaa cccctgcgtc cacggggcct gccgggacag     2460

cctcaacggg tacaagtgcg actgtgaccc tgggtggagt gggaccaact gtgacatcaa     2520

caacaatgag tgtgaatcca acccttgtgt caacggcggc acctgcaaag acatgaccag     2580

tggctacgtg tgcacctgcc gggagggctt cagcggtccc aactgccaga ccaacatcaa     2640

cgagtgtgcg tccaacccat gtctgaacca gggcacgtgt attgacgacg ttgccgggta     2700

caagtgcaac tgcctgctgc cctacacagg tgccacgtgt gaggtggtgc tggccccgtg     2760

tgcccccagc ccctgcagaa acggcgggga gtgcaggcaa tccgaggact atgagagctt     2820

ctcctgtgtc tgccccacgg gctggcaagg gcagacctgt gaggtcgaca tcaacgagtg     2880

cgttctgagc ccgtgccggc acggcgcatc ctgccagaac acccacggcg gctaccgctg     2940

ccactgccag gccggctaca gtgggcgcaa ctgcgagacc gacatcgacg actgccggcc     3000

caacccgtgt cacaacgggg gctcctgcac agacggcatc aacacggcct tctgcgactg     3060

cctgcccggc ttccggggca ctttctgtga ggaggacatc aacgagtgtg ccagtgaccc     3120

ctgccgcaac ggggccaact gcacggactg cgtggacagc tacacgtgca cctgccccgc     3180

aggcttcagc gggatccact gtgagaacaa cacgcctgac tgcacagaga gctcctgctt     3240

caacggtggc acctgcgtgg acggcatcaa ctcgttcacc tgcctgtgtc cacccggctt     3300

cacgggcagc tactgccagc acgatgtcaa tgagtgcgac tcacagccct gcctgcatgg     3360

cggcacctgt caggacggct gcggctccta caggtgcacc tgcccccagg gctacactgg     3420

ccccaactgc cagaaccttg tgcactggtg tgactcctcg ccctgcaaga acggcggcaa     3480

atgctggcag acccacaccc agtaccgctg cgagtgcccc agcggctgga ccggccttta     3540

ctgcgacgtg cccagcgtgt cctgtgaggt ggctgcgcag cgacaaggtg ttgacgttgc     3600

ccgcctgtgc cagcatggag ggctctgtgt ggacgcgggc aacacgcacc actgccgctg     3660

ccaggcgggc tacacaggca gctactgtga ggacctggtg gacgagtgct cacccagccc     3720

ctgccagaac ggggccacct gcacggacta cctgggcggc tactcctgca agtgcgtggc     3780

cggctaccac ggggtgaact gctctgagga gatcgacgag tgcctctccc acccctgcca     3840

gaacgggggc acctgcctcg acctccccaa cacctacaag tgctcctgcc cacggggcac     3900

tcagggtgtg cactgtgaga tcaacgtgga cgactgcaat ccccccgttg accccgtgtc     3960

ccggagcccc aagtgcttta acaacggcac ctgcgtggac caggtgggcg gctacagctg     4020

cacctgcccg ccgggcttcg tgggtgagcg ctgtgagggg gatgtcaacg agtgcctgtc     4080

caatccctgc gacgcccgtg gcacccagaa ctgcgtgcag cgcgtcaatg acttccactg     4140

cgagtgccgt gctggtcaca ccgggcgccg ctgcgagtcc gtcatcaatg gctgcaaagg     4200

caagccctgc aagaatgggg gcacctgcgc cgtggcctcc aacaccgccc gcgggttcat     4260

ctgcaagtgc cctgcgggct tcgagggcgc cacgtgtgag aatgacgctc gtacctgcgg     4320

cagcctgcgc tgcctcaacg gcggcacatg catctccggc ccgcgcagcc ccacctgcct     4380

gtgcctgggc cccttcacgg gccccgaatg ccagttcccg gccagcagcc cctgcctggg     4440

cggcaacccc tgctacaacc aggggacctg tgagcccaca tccgagagcc ccttctaccg     4500

ttgcctgtgc cccgccaaat tcaacgggct cttgtgccac atcctggact acagcttcgg     4560

gggtggggcc gggcgcgaca tccccccgcc gctgatcgag gaggcgtgcg agctgcccga     4620

gtgccaggag gacgcgggca acaaggtctg cagcctgcag tgcaacaacc acgcgtgcgg     4680

ctgggacggc ggtgactgct ccctcaactt caatgacccc tggaagaact gcacgcagtc     4740

tctgcagtgc tggaagtact tcagtgacgg ccactgtgac agccagtgca actcagccgg     4800

ctgcctcttc gacggctttg actgccagcg tgcggaaggc cagtgcaacc ccctgtacga     4860

ccagtactgc aaggaccact tcagcgacgg gcactgcgac cagggctgca acagcgcgga     4920

gtgcgagtgg gacgggctgg actgtgcgga gcatgtaccc gagaggctgg cggccggcac     4980

gctggtggtg gtggtgctga tgccgccgga gcagctgcgc aacagctcct tccacttcct     5040

gcgggagctc agccgcgtgc tgcacaccaa cgtggtcttc aagcgtgacg cacacggcca     5100

gcagatgatc ttcccctact acggccgcga ggaggagctg cgcaagcacc ccatcaagcg     5160

tgccgccgag ggctgggccg cacctgacgc cctgctgggc caggtgaagg cctcgctgct     5220

ccctggtggc agcgagggtg ggcggcggcg gagggagctg gaccccatgg acgtccgcgg     5280

ctccatcgtc tacctggaga ttgacaaccg gcagtgtgtg caggcctcct cgcagtgctt     5340

ccagagtgcc accgacgtgg ccgcattcct gggagcgctc gcctcgctgg gcagcctcaa     5400

catcccctac aagatcgagg ccgtgcagag tgagaccgtg gagccgcccc cgccggcgca     5460

gctgcacttc atgtacgtgg cggcggccgc ctttgtgctt ctgttcttcg tgggctgcgg     5520

ggtgctgctg tcccgcaagc gccggcggca gcatggccag ctctggttcc ctgagggctt     5580

caaagtgtct gaggccagca agaagaagcg gcgggagccc ctcggcgagg actccgtggg     5640

cctcaagccc ctgaagaacg cttcagacgg tgccctcatg gacgacaacc agaatgagtg     5700

gggggacgag gacctggaga ccaagaagtt ccggttcgag gagcccgtgg ttctgcctga     5760

cctggacgac cagacagacc accggcagtg gactcagcag cacctggatg ccgctgacct     5820

gcgcatgtct gccatggccc ccacaccgcc ccagggtgag gttgacgccg actgcatgga     5880

cgtcaatgtc cgcgggcctg atggcttcac cccgctcatg atcgcctcct gcagcggggg     5940

cggcctggag acgggcaaca gcgaggaaga ggaggacgcg ccggccgtca tctccgactt     6000

catctaccag ggcgccagcc tgcacaacca gacagaccgc acgggcgaga ccgccttgca     6060

cctggccgcc cgctactcac gctctgatgc cgccaagcgc ctgctggagg ccagcgcaga     6120

tgccaacatc caggacaaca tgggccgcac cccgctgcat gcggctgtgt ctgccgacgc     6180

acaaggtgtc ttccagatcc tgatccggaa ccgagccaca gacctggatg cccgcatgca     6240

tgatggcacg acgccactga tcctggctgc ccgcctggcc gtggagggca tgctggagga     6300

cctcatcaac tcacacgccg acgtcaacgc cgtagatgac ctgggcaagt ccgccctgca     6360

ctgggccgcc gccgtgaaca atgtggatgc cgcagttgtg ctcctgaaga acggggctaa     6420

caaagatatg cagaacaaca gggaggagac acccctgttt ctggccgccc gggagggcag     6480

ctacgagacc gccaaggtgc tgctggacca ctttgccaac cgggacatca cggatcatat     6540

ggaccgcctg ccgcgcgaca tcgcacagga gcgcatgcat cacgacatcg tgaggctgct     6600

ggacgagtac aacctggtgc gcagcccgca gctgcacgga gccccgctgg ggggcacgcc     6660

caccctgtcg cccccgctct gctcgcccaa cggctacctg ggcagcctca agcccggcgt     6720

gcagggcaag aaggtccgca agcccagcag caaaggcctg gcctgtggaa gcaaggaggc     6780

caaggacctc aaggcacgga ggaagaagtc ccaggacggc aagggctgcc tgctggacag     6840

ctccggcatg ctctcgcccg tggactccct ggagtcaccc catggctacc tgtcagacgt     6900

ggcctcgccg ccactgctgc cctccccgtt ccagcagtct ccgtccgtgc ccctcaacca     6960

cctgcctggg atgcccgaca cccacctggg catcgggcac ctgaacgtgg cggccaagcc     7020

cgagatggcg gcgctgggtg ggggcggccg gctggccttt gagactggcc cacctcgtct     7080

ctcccacctg cctgtggcct ctggcaccag caccgtcctg ggctccagca gcggaggggc     7140

cctgaatttc actgtgggcg ggtccaccag tttgaatggt caatgcgagt ggctgtcccg     7200

gctgcagagc ggcatggtgc cgaaccaata caaccctctg cgggggagtg tggcaccagg     7260

ccccctgagc acacaggccc cctccctgca gcatggcatg gtaggcccgc tgcacagtag     7320

ccttgctgcc agcgccctgt cccagatgat gagctaccag ggcctgccca gcacccggct     7380

ggccacccag cctcacctgg tgcagaccca gcaggtgcag ccacaaaact tacagatgca     7440

gcagcagaac ctgcagccag caaacatcca gcagcagcaa agcctgcagc cgccaccacc     7500

accaccacag ccgcaccttg gcgtgagctc agcagccagc ggccacctgg gccggagctt     7560

cctgagtgga gagccgagcc aggcagacgt gcagccactg ggccccagca gcctggcggt     7620

gcacactatt ctgccccagg agagccccgc cctgcccacg tcgctgccat cctcgctggt     7680

cccacccgtg accgcagccc agttcctgac gcccccctcg cagcacagct actcctcgcc     7740

tgtggacaac acccccagcc accagctaca ggtgcctgag caccccttcc tcaccccgtc     7800

ccctgagtcc cctgaccagt ggtccagctc gtccccgcat tccaacgtct ccgactggtc     7860

cgagggcgtc tccagccctc ccaccagcat gcagtcccag atcgcccgca ttccggaggc     7920

cttcaagtaa acggcgcgcc ccacgagacc ccggcttcct ttcccaagcc ttcgggcgtc     7980

tgtgtgcgct ctgtggatgc cagggccgac cagaggagcc tttttaaaac acatgttttt     8040

atacaaaata agaacgagga ttttaatttt ttttagtatt tatttatgta cttttatttt     8100

acacagaaac actgcctttt tatttatatg tactgtttta tctggcccca ggtagaaact     8160

tttatctatt ctgagaaaac aagcaagttc tgagagccag ggttttccta cgtaggatga     8220

aaagattctt ctgtgtttat aaaatataaa caaagattca tgatttataa atgccattta     8280

tttattgatt ccttttttca aaatccaaaa agaaatgatg ttggagaagg gaagttgaac     8340

gagcatagtc caaaaagctc ctggggcgtc caggccgcgc cctttccccg acgcccaccc     8400

aaccccaagc cagcccggcc gctccaccag catcacctgc ctgttaggag aagctgcatc     8460

cagaggcaaa cggaggcaaa gctggctcac cttccgcacg cggattaatt tgcatctgaa     8520

ataggaaaca agtgaaagca tatgggttag atgttgccat gtgttttaga tggtttcttg     8580

caagcatgct tgtgaaaatg tgttctcgga gtgtgtatgc caagagtgca cccatggtac     8640

caatcatgaa tctttgtttc aggttcagta ttatgtagtt gttcgttggt tatacaagtt     8700

cttggtccct ccagaaccac cccggccccc tgcccgttct tgaaatgtag gcatcatgca     8760

tgtcaaacat gagatgtgtg gactgtggca cttgcctggg tcacacacgg aggcatccta     8820

cccttttctg gggaaagaca ctgcctgggc tgaccccggt ggcggcccca gcacctcagc     8880

ctgcacagtg tcccccaggt tccgaagaag atgctccagc aacacagcct gggccccagc     8940

tcgcgggacc cgaccccccg tgggctcccg tgttttgtag gagacttgcc agagccgggc     9000

acattgagct gtgcaacgcc gtgggctgcg tcctttggtc ctgtccccgc agccctggca     9060

gggggcatgc ggtcgggcag gggctggagg gaggcggggg ctgcccttgg gccacccctc     9120

ctagtttggg aggagcagat ttttgcaata ccaagtatag cctatggcag aaaaaatgtc     9180

tgtaaatatg tttttaaagg tggattttgt ttaaaaaatc ttaatgaatg agtctgttgt     9240

gtgtcatgcc agtgagggac gtcagacttg gctcagctcg gggagcctta gccgcccatg     9300

cactggggac gctccgctgc cgtgccgcct gcactcctca gggcagcctc ccccggctct     9360

acgggggccg cgtggtgcca tccccagggg gcatgaccag atgcgtccca agatgttgat     9420

ttttactgtg ttttataaaa tagagtgtag tttacagaaa aagactttaa aagtgatcta     9480

catgaggaac tgtagatgat gtattttttt catctttttt gttaactgat ttgcaataaa     9540

aatgatactg atggtgatct ggcttcca                                        9568


<210>  2
<211>  2555
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Arg Cys Ser Gln Pro Gly Glu Thr Cys Leu 
            20                  25                  30          


Asn Gly Gly Lys Cys Glu Ala Ala Asn Gly Thr Glu Ala Cys Val Cys 
        35                  40                  45              


Gly Gly Ala Phe Val Gly Pro Arg Cys Gln Asp Pro Asn Pro Cys Leu 
    50                  55                  60                  


Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys His Val Val Asp Arg Arg 
65                  70                  75                  80  


Gly Val Ala Asp Tyr Ala Cys Ser Cys Ala Leu Gly Phe Ser Gly Pro 
                85                  90                  95      


Leu Cys Leu Thr Pro Leu Asp Asn Ala Cys Leu Thr Asn Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
        115                 120                 125             


Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
    130                 135                 140                 


Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ala 
145                 150                 155                 160 


Ser Tyr Ile Cys His Cys Pro Pro Ser Phe His Gly Pro Thr Cys Arg 
                165                 170                 175     


Gln Asp Val Asn Glu Cys Gly Gln Lys Pro Gly Leu Cys Arg His Gly 
            180                 185                 190         


Gly Thr Cys His Asn Glu Val Gly Ser Tyr Arg Cys Val Cys Arg Ala 
        195                 200                 205             


Thr His Thr Gly Pro Asn Cys Glu Arg Pro Tyr Val Pro Cys Ser Pro 
    210                 215                 220                 


Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Val Thr 
225                 230                 235                 240 


His Glu Cys Ala Cys Leu Pro Gly Phe Thr Gly Gln Asn Cys Glu Glu 
                245                 250                 255     


Asn Ile Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
            260                 265                 270         


Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 
        275                 280                 285             


Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
    290                 295                 300                 


Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr His Gly Gly Tyr Asn 
305                 310                 315                 320 


Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile 
                325                 330                 335     


Asp Asp Cys Ala Ser Ala Ala Cys Phe His Gly Ala Thr Cys His Asp 
            340                 345                 350         


Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
        355                 360                 365             


Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
    370                 375                 380                 


Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
385                 390                 395                 400 


Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                405                 410                 415     


Ser Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Ile Asn Thr 
            420                 425                 430         


Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
        435                 440                 445             


Cys Glu Ile Asp Val Asn Glu Cys Val Ser Asn Pro Cys Gln Asn Asp 
    450                 455                 460                 


Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
465                 470                 475                 480 


Gly Tyr Glu Gly Val His Cys Glu Val Asn Thr Asp Glu Cys Ala Ser 
                485                 490                 495     


Ser Pro Cys Leu His Asn Gly Arg Cys Leu Asp Lys Ile Asn Glu Phe 
            500                 505                 510         


Gln Cys Glu Cys Pro Thr Gly Phe Thr Gly His Leu Cys Gln Tyr Asp 
        515                 520                 525             


Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
    530                 535                 540                 


Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
545                 550                 555                 560 


Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                565                 570                 575     


Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Arg 
            580                 585                 590         


Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys Ser 
        595                 600                 605             


Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Ala 
    610                 615                 620                 


Tyr Leu Cys Phe Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
625                 630                 635                 640 


Asn Leu Asp Asp Cys Ala Ser Ser Pro Cys Asp Ser Gly Thr Cys Leu 
                645                 650                 655     


Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
            660                 665                 670         


Ser Met Cys Asn Ile Asn Ile Asp Glu Cys Ala Gly Asn Pro Cys His 
        675                 680                 685             


Asn Gly Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe Thr Cys Arg Cys 
    690                 695                 700                 


Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
705                 710                 715                 720 


Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp Ser Leu Asn Gly 
                725                 730                 735     


Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
            740                 745                 750         


Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
        755                 760                 765             


Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
    770                 775                 780                 


Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
785                 790                 795                 800 


Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                805                 810                 815     


Cys Leu Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
            820                 825                 830         


Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Glu Cys Arg Gln Ser Glu 
        835                 840                 845             


Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
    850                 855                 860                 


Thr Cys Glu Val Asp Ile Asn Glu Cys Val Leu Ser Pro Cys Arg His 
865                 870                 875                 880 


Gly Ala Ser Cys Gln Asn Thr His Gly Gly Tyr Arg Cys His Cys Gln 
                885                 890                 895     


Ala Gly Tyr Ser Gly Arg Asn Cys Glu Thr Asp Ile Asp Asp Cys Arg 
            900                 905                 910         


Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn Thr 
        915                 920                 925             


Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr Phe Cys Glu Glu 
    930                 935                 940                 


Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn Gly Ala Asn Cys 
945                 950                 955                 960 


Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Ala Gly Phe Ser 
                965                 970                 975     


Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
            980                 985                 990         


Phe Asn Gly Gly Thr Cys Val Asp  Gly Ile Asn Ser Phe  Thr Cys Leu 
        995                 1000                 1005             


Cys Pro  Pro Gly Phe Thr Gly  Ser Tyr Cys Gln His  Asp Val Asn 
    1010                 1015                 1020             


Glu Cys  Asp Ser Gln Pro Cys  Leu His Gly Gly Thr  Cys Gln Asp 
    1025                 1030                 1035             


Gly Cys  Gly Ser Tyr Arg Cys  Thr Cys Pro Gln Gly  Tyr Thr Gly 
    1040                 1045                 1050             


Pro Asn  Cys Gln Asn Leu Val  His Trp Cys Asp Ser  Ser Pro Cys 
    1055                 1060                 1065             


Lys Asn  Gly Gly Lys Cys Trp  Gln Thr His Thr Gln  Tyr Arg Cys 
    1070                 1075                 1080             


Glu Cys  Pro Ser Gly Trp Thr  Gly Leu Tyr Cys Asp  Val Pro Ser 
    1085                 1090                 1095             


Val Ser  Cys Glu Val Ala Ala  Gln Arg Gln Gly Val  Asp Val Ala 
    1100                 1105                 1110             


Arg Leu  Cys Gln His Gly Gly  Leu Cys Val Asp Ala  Gly Asn Thr 
    1115                 1120                 1125             


His His  Cys Arg Cys Gln Ala  Gly Tyr Thr Gly Ser  Tyr Cys Glu 
    1130                 1135                 1140             


Asp Leu  Val Asp Glu Cys Ser  Pro Ser Pro Cys Gln  Asn Gly Ala 
    1145                 1150                 1155             


Thr Cys  Thr Asp Tyr Leu Gly  Gly Tyr Ser Cys Lys  Cys Val Ala 
    1160                 1165                 1170             


Gly Tyr  His Gly Val Asn Cys  Ser Glu Glu Ile Asp  Glu Cys Leu 
    1175                 1180                 1185             


Ser His  Pro Cys Gln Asn Gly  Gly Thr Cys Leu Asp  Leu Pro Asn 
    1190                 1195                 1200             


Thr Tyr  Lys Cys Ser Cys Pro  Arg Gly Thr Gln Gly  Val His Cys 
    1205                 1210                 1215             


Glu Ile  Asn Val Asp Asp Cys  Asn Pro Pro Val Asp  Pro Val Ser 
    1220                 1225                 1230             


Arg Ser  Pro Lys Cys Phe Asn  Asn Gly Thr Cys Val  Asp Gln Val 
    1235                 1240                 1245             


Gly Gly  Tyr Ser Cys Thr Cys  Pro Pro Gly Phe Val  Gly Glu Arg 
    1250                 1255                 1260             


Cys Glu  Gly Asp Val Asn Glu  Cys Leu Ser Asn Pro  Cys Asp Ala 
    1265                 1270                 1275             


Arg Gly  Thr Gln Asn Cys Val  Gln Arg Val Asn Asp  Phe His Cys 
    1280                 1285                 1290             


Glu Cys  Arg Ala Gly His Thr  Gly Arg Arg Cys Glu  Ser Val Ile 
    1295                 1300                 1305             


Asn Gly  Cys Lys Gly Lys Pro  Cys Lys Asn Gly Gly  Thr Cys Ala 
    1310                 1315                 1320             


Val Ala  Ser Asn Thr Ala Arg  Gly Phe Ile Cys Lys  Cys Pro Ala 
    1325                 1330                 1335             


Gly Phe  Glu Gly Ala Thr Cys  Glu Asn Asp Ala Arg  Thr Cys Gly 
    1340                 1345                 1350             


Ser Leu  Arg Cys Leu Asn Gly  Gly Thr Cys Ile Ser  Gly Pro Arg 
    1355                 1360                 1365             


Ser Pro  Thr Cys Leu Cys Leu  Gly Pro Phe Thr Gly  Pro Glu Cys 
    1370                 1375                 1380             


Gln Phe  Pro Ala Ser Ser Pro  Cys Leu Gly Gly Asn  Pro Cys Tyr 
    1385                 1390                 1395             


Asn Gln  Gly Thr Cys Glu Pro  Thr Ser Glu Ser Pro  Phe Tyr Arg 
    1400                 1405                 1410             


Cys Leu  Cys Pro Ala Lys Phe  Asn Gly Leu Leu Cys  His Ile Leu 
    1415                 1420                 1425             


Asp Tyr  Ser Phe Gly Gly Gly  Ala Gly Arg Asp Ile  Pro Pro Pro 
    1430                 1435                 1440             


Leu Ile  Glu Glu Ala Cys Glu  Leu Pro Glu Cys Gln  Glu Asp Ala 
    1445                 1450                 1455             


Gly Asn  Lys Val Cys Ser Leu  Gln Cys Asn Asn His  Ala Cys Gly 
    1460                 1465                 1470             


Trp Asp  Gly Gly Asp Cys Ser  Leu Asn Phe Asn Asp  Pro Trp Lys 
    1475                 1480                 1485             


Asn Cys  Thr Gln Ser Leu Gln  Cys Trp Lys Tyr Phe  Ser Asp Gly 
    1490                 1495                 1500             


His Cys  Asp Ser Gln Cys Asn  Ser Ala Gly Cys Leu  Phe Asp Gly 
    1505                 1510                 1515             


Phe Asp  Cys Gln Arg Ala Glu  Gly Gln Cys Asn Pro  Leu Tyr Asp 
    1520                 1525                 1530             


Gln Tyr  Cys Lys Asp His Phe  Ser Asp Gly His Cys  Asp Gln Gly 
    1535                 1540                 1545             


Cys Asn  Ser Ala Glu Cys Glu  Trp Asp Gly Leu Asp  Cys Ala Glu 
    1550                 1555                 1560             


His Val  Pro Glu Arg Leu Ala  Ala Gly Thr Leu Val  Val Val Val 
    1565                 1570                 1575             


Leu Met  Pro Pro Glu Gln Leu  Arg Asn Ser Ser Phe  His Phe Leu 
    1580                 1585                 1590             


Arg Glu  Leu Ser Arg Val Leu  His Thr Asn Val Val  Phe Lys Arg 
    1595                 1600                 1605             


Asp Ala  His Gly Gln Gln Met  Ile Phe Pro Tyr Tyr  Gly Arg Glu 
    1610                 1615                 1620             


Glu Glu  Leu Arg Lys His Pro  Ile Lys Arg Ala Ala  Glu Gly Trp 
    1625                 1630                 1635             


Ala Ala  Pro Asp Ala Leu Leu  Gly Gln Val Lys Ala  Ser Leu Leu 
    1640                 1645                 1650             


Pro Gly  Gly Ser Glu Gly Gly  Arg Arg Arg Arg Glu  Leu Asp Pro 
    1655                 1660                 1665             


Met Asp  Val Arg Gly Ser Ile  Val Tyr Leu Glu Ile  Asp Asn Arg 
    1670                 1675                 1680             


Gln Cys  Val Gln Ala Ser Ser  Gln Cys Phe Gln Ser  Ala Thr Asp 
    1685                 1690                 1695             


Val Ala  Ala Phe Leu Gly Ala  Leu Ala Ser Leu Gly  Ser Leu Asn 
    1700                 1705                 1710             


Ile Pro  Tyr Lys Ile Glu Ala  Val Gln Ser Glu Thr  Val Glu Pro 
    1715                 1720                 1725             


Pro Pro  Pro Ala Gln Leu His  Phe Met Tyr Val Ala  Ala Ala Ala 
    1730                 1735                 1740             


Phe Val  Leu Leu Phe Phe Val  Gly Cys Gly Val Leu  Leu Ser Arg 
    1745                 1750                 1755             


Lys Arg  Arg Arg Gln His Gly  Gln Leu Trp Phe Pro  Glu Gly Phe 
    1760                 1765                 1770             


Lys Val  Ser Glu Ala Ser Lys  Lys Lys Arg Arg Glu  Pro Leu Gly 
    1775                 1780                 1785             


Glu Asp  Ser Val Gly Leu Lys  Pro Leu Lys Asn Ala  Ser Asp Gly 
    1790                 1795                 1800             


Ala Leu  Met Asp Asp Asn Gln  Asn Glu Trp Gly Asp  Glu Asp Leu 
    1805                 1810                 1815             


Glu Thr  Lys Lys Phe Arg Phe  Glu Glu Pro Val Val  Leu Pro Asp 
    1820                 1825                 1830             


Leu Asp  Asp Gln Thr Asp His  Arg Gln Trp Thr Gln  Gln His Leu 
    1835                 1840                 1845             


Asp Ala  Ala Asp Leu Arg Met  Ser Ala Met Ala Pro  Thr Pro Pro 
    1850                 1855                 1860             


Gln Gly  Glu Val Asp Ala Asp  Cys Met Asp Val Asn  Val Arg Gly 
    1865                 1870                 1875             


Pro Asp  Gly Phe Thr Pro Leu  Met Ile Ala Ser Cys  Ser Gly Gly 
    1880                 1885                 1890             


Gly Leu  Glu Thr Gly Asn Ser  Glu Glu Glu Glu Asp  Ala Pro Ala 
    1895                 1900                 1905             


Val Ile  Ser Asp Phe Ile Tyr  Gln Gly Ala Ser Leu  His Asn Gln 
    1910                 1915                 1920             


Thr Asp  Arg Thr Gly Glu Thr  Ala Leu His Leu Ala  Ala Arg Tyr 
    1925                 1930                 1935             


Ser Arg  Ser Asp Ala Ala Lys  Arg Leu Leu Glu Ala  Ser Ala Asp 
    1940                 1945                 1950             


Ala Asn  Ile Gln Asp Asn Met  Gly Arg Thr Pro Leu  His Ala Ala 
    1955                 1960                 1965             


Val Ser  Ala Asp Ala Gln Gly  Val Phe Gln Ile Leu  Ile Arg Asn 
    1970                 1975                 1980             


Arg Ala  Thr Asp Leu Asp Ala  Arg Met His Asp Gly  Thr Thr Pro 
    1985                 1990                 1995             


Leu Ile  Leu Ala Ala Arg Leu  Ala Val Glu Gly Met  Leu Glu Asp 
    2000                 2005                 2010             


Leu Ile  Asn Ser His Ala Asp  Val Asn Ala Val Asp  Asp Leu Gly 
    2015                 2020                 2025             


Lys Ser  Ala Leu His Trp Ala  Ala Ala Val Asn Asn  Val Asp Ala 
    2030                 2035                 2040             


Ala Val  Val Leu Leu Lys Asn  Gly Ala Asn Lys Asp  Met Gln Asn 
    2045                 2050                 2055             


Asn Arg  Glu Glu Thr Pro Leu  Phe Leu Ala Ala Arg  Glu Gly Ser 
    2060                 2065                 2070             


Tyr Glu  Thr Ala Lys Val Leu  Leu Asp His Phe Ala  Asn Arg Asp 
    2075                 2080                 2085             


Ile Thr  Asp His Met Asp Arg  Leu Pro Arg Asp Ile  Ala Gln Glu 
    2090                 2095                 2100             


Arg Met  His His Asp Ile Val  Arg Leu Leu Asp Glu  Tyr Asn Leu 
    2105                 2110                 2115             


Val Arg  Ser Pro Gln Leu His  Gly Ala Pro Leu Gly  Gly Thr Pro 
    2120                 2125                 2130             


Thr Leu  Ser Pro Pro Leu Cys  Ser Pro Asn Gly Tyr  Leu Gly Ser 
    2135                 2140                 2145             


Leu Lys  Pro Gly Val Gln Gly  Lys Lys Val Arg Lys  Pro Ser Ser 
    2150                 2155                 2160             


Lys Gly  Leu Ala Cys Gly Ser  Lys Glu Ala Lys Asp  Leu Lys Ala 
    2165                 2170                 2175             


Arg Arg  Lys Lys Ser Gln Asp  Gly Lys Gly Cys Leu  Leu Asp Ser 
    2180                 2185                 2190             


Ser Gly  Met Leu Ser Pro Val  Asp Ser Leu Glu Ser  Pro His Gly 
    2195                 2200                 2205             


Tyr Leu  Ser Asp Val Ala Ser  Pro Pro Leu Leu Pro  Ser Pro Phe 
    2210                 2215                 2220             


Gln Gln  Ser Pro Ser Val Pro  Leu Asn His Leu Pro  Gly Met Pro 
    2225                 2230                 2235             


Asp Thr  His Leu Gly Ile Gly  His Leu Asn Val Ala  Ala Lys Pro 
    2240                 2245                 2250             


Glu Met  Ala Ala Leu Gly Gly  Gly Gly Arg Leu Ala  Phe Glu Thr 
    2255                 2260                 2265             


Gly Pro  Pro Arg Leu Ser His  Leu Pro Val Ala Ser  Gly Thr Ser 
    2270                 2275                 2280             


Thr Val  Leu Gly Ser Ser Ser  Gly Gly Ala Leu Asn  Phe Thr Val 
    2285                 2290                 2295             


Gly Gly  Ser Thr Ser Leu Asn  Gly Gln Cys Glu Trp  Leu Ser Arg 
    2300                 2305                 2310             


Leu Gln  Ser Gly Met Val Pro  Asn Gln Tyr Asn Pro  Leu Arg Gly 
    2315                 2320                 2325             


Ser Val  Ala Pro Gly Pro Leu  Ser Thr Gln Ala Pro  Ser Leu Gln 
    2330                 2335                 2340             


His Gly  Met Val Gly Pro Leu  His Ser Ser Leu Ala  Ala Ser Ala 
    2345                 2350                 2355             


Leu Ser  Gln Met Met Ser Tyr  Gln Gly Leu Pro Ser  Thr Arg Leu 
    2360                 2365                 2370             


Ala Thr  Gln Pro His Leu Val  Gln Thr Gln Gln Val  Gln Pro Gln 
    2375                 2380                 2385             


Asn Leu  Gln Met Gln Gln Gln  Asn Leu Gln Pro Ala  Asn Ile Gln 
    2390                 2395                 2400             


Gln Gln  Gln Ser Leu Gln Pro  Pro Pro Pro Pro Pro  Gln Pro His 
    2405                 2410                 2415             


Leu Gly  Val Ser Ser Ala Ala  Ser Gly His Leu Gly  Arg Ser Phe 
    2420                 2425                 2430             


Leu Ser  Gly Glu Pro Ser Gln  Ala Asp Val Gln Pro  Leu Gly Pro 
    2435                 2440                 2445             


Ser Ser  Leu Ala Val His Thr  Ile Leu Pro Gln Glu  Ser Pro Ala 
    2450                 2455                 2460             


Leu Pro  Thr Ser Leu Pro Ser  Ser Leu Val Pro Pro  Val Thr Ala 
    2465                 2470                 2475             


Ala Gln  Phe Leu Thr Pro Pro  Ser Gln His Ser Tyr  Ser Ser Pro 
    2480                 2485                 2490             


Val Asp  Asn Thr Pro Ser His  Gln Leu Gln Val Pro  Glu His Pro 
    2495                 2500                 2505             


Phe Leu  Thr Pro Ser Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser 
    2510                 2515                 2520             


Ser Pro  His Ser Asn Val Ser  Asp Trp Ser Glu Gly  Val Ser Ser 
    2525                 2530                 2535             


Pro Pro  Thr Ser Met Gln Ser  Gln Ile Ala Arg Ile  Pro Glu Ala 
    2540                 2545                 2550             


Phe Lys  
    2555 


<210>  3
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
caccgcaaca tcccctacaa gatcg                                             25


<210>  4
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
aaaccgatct tgtaggggat gttgc                                             25


<210>  5
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
caccgtgaag cggccaatgg cacgg                                             25


<210>  6
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
aaacccgtgc cattggccgc ttcac                                             25


<210>  7
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
agccgctccg ctgtcctg                                                     18


<210>  8
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
caggacagcg gagcggctc                                                    19


