                               SEQUENCE LISTING

<110> SANOFI
 
<120> EXPRESSION OF ANTIGEN-BINDING PROTEINS IN THE NERVOUS SYSTEM

<130> 022548.WO060

<140>
<141>

<150> EP 19306310.4
<151> 2019-10-08

<150> 62/848,659
<151> 2019-05-16

<160> 9     

<170> PatentIn version 3.5

<210> 1
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1
Gly Gly Gly Ser 
1               


<210> 2
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 2
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 3
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 3
Gly Gly Gly Gly Ser 
1               5   


<210> 4
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(20) 
<223> /note="This sequence may encompass 1-4 'Gly Gly Gly Gly Ser'
      repeating units"

<400> 4
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 5
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 5
Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 6
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (10)..(10)
<223> /replace="Ala" or "Asn"

<220>
<221> VARIANT
<222> (15)..(15)
<223> /replace="Asn"

<220>
<221> SITE
<222> (1)..(20)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 6
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 7
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 7
Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   


<210> 8
<211> 530
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Ser Glu 
            20                  25                  30          


Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp 
        35                  40                  45              


Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser Asn 
    50                  55                  60                  


Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
65                  70                  75                  80  


Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro Asp 
                85                  90                  95      


Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Ser 
            100                 105                 110         


Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn Thr 
        115                 120                 125             


Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
    130                 135                 140                 


Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro 
                165                 170                 175     


Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr 
            180                 185                 190         


Asp Tyr Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu 
        195                 200                 205             


Trp Ile Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro 
    210                 215                 220                 


Ser Phe Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr 
225                 230                 235                 240 


Ala Tyr Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr 
                245                 250                 255     


Tyr Cys Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser 
            260                 265                 270         


Val Thr Val Ser Ser Ala Ser Thr Gly Gly Gly Gly Gly Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr 
    290                 295                 300                 


Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
305                 310                 315                 320 


Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp 
                325                 330                 335     


Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp 
            340                 345                 350         


Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Ala 
        355                 360                 365             


Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp 
    370                 375                 380                 


Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro 
385                 390                 395                 400 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala 
                405                 410                 415     


Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp 
            420                 425                 430         


Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile 
        435                 440                 445             


Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn 
    450                 455                 460                 


Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys 
465                 470                 475                 480 


Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys 
                485                 490                 495     


Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu 
            500                 505                 510         


Ser His Ser Pro Gly Ser Gly Ser Gly Ser Gly Ser His His His His 
        515                 520                 525             


His His 
    530 


<210> 9
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 9
His His His His His His 
1               5       


