                         SEQUENCE LISTING

<110>  Alectos Therapeutics Inc.
 
<120>  NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF

<130>  10103-030WO1

<140>  PCT/IB2020/054355
<141>  2020-05-07

<150>  62/846,011
<151>  2019-05-10

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  926
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Thr Gln Asp Pro Gly Asn Met Gly Thr Gly Val Pro Ala Ser 
1               5                   10                  15      


Glu Gln Ile Ser Cys Ala Lys Glu Asp Pro Gln Val Tyr Cys Pro Glu 
            20                  25                  30          


Glu Thr Gly Gly Thr Lys Asp Val Gln Val Thr Asp Cys Lys Ser Pro 
        35                  40                  45              


Glu Asp Ser Arg Pro Pro Lys Glu Thr Asp Cys Cys Asn Pro Glu Asp 
    50                  55                  60                  


Ser Gly Gln Leu Met Val Ser Tyr Glu Gly Lys Ala Met Gly Tyr Gln 
65                  70                  75                  80  


Val Pro Pro Phe Gly Trp Arg Ile Cys Leu Ala His Glu Phe Thr Glu 
                85                  90                  95      


Lys Arg Lys Pro Phe Gln Ala Asn Asn Val Ser Leu Ser Asn Met Ile 
            100                 105                 110         


Lys His Ile Gly Met Gly Leu Arg Tyr Leu Gln Trp Trp Tyr Arg Lys 
        115                 120                 125             


Thr His Val Glu Lys Lys Thr Pro Phe Ile Asp Met Ile Asn Ser Val 
    130                 135                 140                 


Pro Leu Arg Gln Ile Tyr Gly Cys Pro Leu Gly Gly Ile Gly Gly Gly 
145                 150                 155                 160 


Thr Ile Thr Arg Gly Trp Arg Gly Gln Phe Cys Arg Trp Gln Leu Asn 
                165                 170                 175     


Pro Gly Met Tyr Gln His Arg Thr Val Ile Ala Asp Gln Phe Thr Val 
            180                 185                 190         


Cys Leu Arg Arg Glu Gly Gln Thr Val Tyr Gln Gln Val Leu Ser Leu 
        195                 200                 205             


Glu Arg Pro Ser Val Leu Arg Ser Trp Asn Trp Gly Leu Cys Gly Tyr 
    210                 215                 220                 


Phe Ala Phe Tyr His Ala Leu Tyr Pro Arg Ala Trp Thr Val Tyr Gln 
225                 230                 235                 240 


Leu Pro Gly Gln Asn Val Thr Leu Thr Cys Arg Gln Ile Thr Pro Ile 
                245                 250                 255     


Leu Pro His Asp Tyr Gln Asp Ser Ser Leu Pro Val Gly Val Phe Val 
            260                 265                 270         


Trp Asp Val Glu Asn Glu Gly Asp Glu Ala Leu Asp Val Ser Ile Met 
        275                 280                 285             


Phe Ser Met Arg Asn Gly Leu Gly Gly Gly Asp Asp Ala Pro Gly Gly 
    290                 295                 300                 


Leu Trp Asn Glu Pro Phe Cys Leu Glu Arg Ser Gly Glu Thr Val Arg 
305                 310                 315                 320 


Gly Leu Leu Leu His His Pro Thr Leu Pro Asn Pro Tyr Thr Met Ala 
                325                 330                 335     


Val Ala Ala Arg Val Thr Ala Ala Thr Thr Val Thr His Ile Thr Ala 
            340                 345                 350         


Phe Asp Pro Asp Ser Thr Gly Gln Gln Val Trp Gln Asp Leu Leu Gln 
        355                 360                 365             


Asp Gly Gln Leu Asp Ser Pro Thr Gly Gln Ser Thr Pro Thr Gln Lys 
    370                 375                 380                 


Gly Val Gly Ile Ala Gly Ala Val Cys Val Ser Ser Lys Leu Arg Pro 
385                 390                 395                 400 


Arg Gly Gln Cys Arg Leu Glu Phe Ser Leu Ala Trp Asp Met Pro Arg 
                405                 410                 415     


Ile Met Phe Ala Lys Gly Gln Val His Tyr Arg Arg Tyr Thr Arg Phe 
            420                 425                 430         


Phe Gly Gln Asp Gly Asp Ala Ala Pro Ala Leu Ser His Tyr Ala Leu 
        435                 440                 445             


Cys Arg Tyr Ala Glu Trp Glu Glu Arg Ile Ser Ala Trp Gln Ser Pro 
    450                 455                 460                 


Val Leu Asp Asp Arg Ser Leu Pro Ala Trp Tyr Lys Ser Ala Leu Phe 
465                 470                 475                 480 


Asn Glu Leu Tyr Phe Leu Ala Asp Gly Gly Thr Val Trp Leu Glu Val 
                485                 490                 495     


Leu Glu Asp Ser Leu Pro Glu Glu Leu Gly Arg Asn Met Cys His Leu 
            500                 505                 510         


Arg Pro Thr Leu Arg Asp Tyr Gly Arg Phe Gly Tyr Leu Glu Gly Gln 
        515                 520                 525             


Glu Tyr Arg Met Tyr Asn Thr Tyr Asp Val His Phe Tyr Ala Ser Phe 
    530                 535                 540                 


Ala Leu Ile Met Leu Trp Pro Lys Leu Glu Leu Ser Leu Gln Tyr Asp 
545                 550                 555                 560 


Met Ala Leu Ala Thr Leu Arg Glu Asp Leu Thr Arg Arg Arg Tyr Leu 
                565                 570                 575     


Met Ser Gly Val Met Ala Pro Val Lys Arg Arg Asn Val Ile Pro His 
            580                 585                 590         


Asp Ile Gly Asp Pro Asp Asp Glu Pro Trp Leu Arg Val Asn Ala Tyr 
        595                 600                 605             


Leu Ile His Asp Thr Ala Asp Trp Lys Asp Leu Asn Leu Lys Phe Val 
    610                 615                 620                 


Leu Gln Val Tyr Arg Asp Tyr Tyr Leu Thr Gly Asp Gln Asn Phe Leu 
625                 630                 635                 640 


Lys Asp Met Trp Pro Val Cys Leu Ala Val Met Glu Ser Glu Met Lys 
                645                 650                 655     


Phe Asp Lys Asp His Asp Gly Leu Ile Glu Asn Gly Gly Tyr Ala Asp 
            660                 665                 670         


Gln Thr Tyr Asp Gly Trp Val Thr Thr Gly Pro Ser Ala Tyr Cys Gly 
        675                 680                 685             


Gly Leu Trp Leu Ala Ala Val Ala Val Met Val Gln Met Ala Ala Leu 
    690                 695                 700                 


Cys Gly Ala Gln Asp Ile Gln Asp Lys Phe Ser Ser Ile Leu Ser Arg 
705                 710                 715                 720 


Gly Gln Glu Ala Tyr Glu Arg Leu Leu Trp Asn Gly Arg Tyr Tyr Asn 
                725                 730                 735     


Tyr Asp Ser Ser Ser Arg Pro Gln Ser Arg Ser Val Met Ser Asp Gln 
            740                 745                 750         


Cys Ala Gly Gln Trp Phe Leu Lys Ala Cys Gly Leu Gly Glu Gly Asp 
        755                 760                 765             


Thr Glu Val Phe Pro Thr Gln His Val Val Arg Ala Leu Gln Thr Ile 
    770                 775                 780                 


Phe Glu Leu Asn Val Gln Ala Phe Ala Gly Gly Ala Met Gly Ala Val 
785                 790                 795                 800 


Asn Gly Met Gln Pro His Gly Val Pro Asp Lys Ser Ser Val Gln Ser 
                805                 810                 815     


Asp Glu Val Trp Val Gly Val Val Tyr Gly Leu Ala Ala Thr Met Ile 
            820                 825                 830         


Gln Glu Gly Leu Thr Trp Glu Gly Phe Gln Thr Ala Glu Gly Cys Tyr 
        835                 840                 845             


Arg Thr Val Trp Glu Arg Leu Gly Leu Ala Phe Gln Thr Pro Glu Ala 
    850                 855                 860                 


Tyr Cys Gln Gln Arg Val Phe Arg Ser Leu Ala Tyr Met Arg Pro Leu 
865                 870                 875                 880 


Ser Ile Trp Ala Met Gln Leu Ala Leu Gln Gln Gln Gln His Lys Lys 
                885                 890                 895     


Ala Ser Trp Pro Lys Val Lys Gln Gly Thr Gly Leu Arg Thr Gly Pro 
            900                 905                 910         


Met Phe Gly Pro Lys Glu Ala Met Ala Asn Leu Ser Pro Glu 
        915                 920                 925     


