                         LISTADO DE SECUENCIAS

<110>  FUNDACION PARA LA INVESTIGACION E INNOVACION BIOSANITARIA 
       PRINCIPADO DE ASTURIAS
 
<120>  INHIBIDORES DE PCSK9 PARA LA PREVENCIN Y/O TRATAMIENTO DE CNCER

<130>  PCT3805.2

<150>  ES P201930429
<151>  2019-05-16

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  32304
<212>  DNA
<213>  Homo sapiens

<400>  1
ctctcttata attccatttg gggtctgtac cttaaatctt atgttgttta tgcagagaca       60

aacattatat atacaaatgt aaccacttta ttgaaatggg atcataacat gctgtttaaa      120

agttattgat gttggacatc tttccatgtc aatatataaa cctccattta tttcttttta      180

ccagctgcca aatatcccac catatgaaca gactaaaatc tgtccctcca ttgatgaatg      240

tttggattgc tgaacccctg gaagaaattc aataagagca aacagaagtg taatatatga      300

caccctggca gatcaaagtg agagttttat tagaggagac agtaaagctg gtggagcggg      360

gagagctaag tgaatcaaca tgttgcagtc ggagccagga ctcataccac cccaagaggc      420

aggaggcagc gcagccagaa gggcactgag gagccatggc cacagctccc tgtggctccc      480

agcagcggga ccagatgcaa acttcccacc ccaccacatg tctgggcttc ctataccctg      540

ttcagtcttt actgagtcag aagctgtttt aagagctgag cacacccatt ttacagcaga      600

gcttcttacg gaaaagcgtg ctgctgtcct ggaccctttg tccatcctgg gccattgggc      660

cagctccagc ctcatccttg aatggtgggt gtacatcgct ggggtccttg ctagattata      720

ttagggcctc cacacacttt agttgctctc cgtttgcaca atgatttcta tatcattagt      780

acctctttgt ccacttgcct aattatttcc ttaggataaa ttcctaagaa atcaaatagc      840

taggtcagta tatagcacat tttcacagtt tgctactgac tagagatatt aaaggtacaa      900

aaacagccag aattagatgt agagtcgcaa gggagttttg ttactaagac gtcatttcta      960

atcagggaga aaaaatgagt tacggaataa acggtattgg aacaataggc tagccttctg     1020

gagaaaaata acctcactcc ttatacaaaa gtaaatccca gtggaagcca agatattaaa     1080

aaaagattta aaaaaggagg acaattttta tatgatcttg ataaggagga ggcctttcta     1140

agcacagtac aaaatcaaga agtcatgaaa taaaaggctg ataagtttga ctccatgaaa     1200

attaaaattt tctatggaaa aaaatacaat aaagtcaaaa atcaatcaac aaactggaaa     1260

atagatttgc aacatacata agagacagca ggctaatttt ggtattatac ataaaaagct     1320

attacaaatc atcaaacaaa agctccacag ccaaaatgaa aaaatgaaga gacagttcaa     1380

agacaaacaa atgtagataa ttgtttaact taaggaaagg tcaaaatatt tggcaactct     1440

gtgttggcct gggtgtgacc atgagcggta gttgccagtg gtattcacaa atataccctt     1500

tctcctcctt ctgggcactt ggtgtgattg cagtttccta catttgacct taggtgtggt     1560

catgtgtctc gcttaggaga aggaaatgtg aacggaagtg ttgtgggtca cttttgtgtg     1620

gaagctgcat ggagtcacct ctttgctttc cgtcagcctc agtgttcagc aatgttctga     1680

atgatggttg ctttatcagt ctggttctgg ggtgagggta atgaagtagt gaagcaaagt     1740

ccttgatgga catgtgaggt gagacagaaa taaacctttg acatttcaag cccctgagat     1800

ttggggcgtg catgtgctgg aagcagaacc tagcctattc tgatggattc ctccagcact     1860

gctcgtggga agacatcatc aatatagagc attcatgtgc cctttatctc gaaattccac     1920

ttccaggaat ttatgaaaca gatactctca catgtgcaaa cagctatgga taaggacaga     1980

catggcaact tggattgcaa tagcaaaaga cagaaacaac caacggaaac accaaccaat     2040

aggaaattgg ctaaagacat tgtgaaacat acatagaatg aaataatctg caaccagaaa     2100

aataaggcag tagatgtatg tgtaccagtg tggtttttat tccgagatta gggctaggtt     2160

aagacgtcag attaagttgt ccctctccac cccaccaata taaataaaaa gttaaaagta     2220

aatcataaac tatttttaca attttaaaaa gtgggttaaa gagcccatcc aagtagtttt     2280

ataaaagtag actatctccg aaaagatacc caataaatag gtatattact ttcctggggc     2340

tgttataaca agtttctaca aatttgctgg cttcaaataa caaaaacgta ttctcttgca     2400

gttatggaag ccagaagtat ggaatgaagg gttgcagggt ggtgccctct cccaaagctc     2460

taggggagga acattccttg cttcttccag ctcctttggg ggctcctggc attccttggc     2520

ttatgtcggc acagctctaa tcggcgcctc cattgttaca taggtgtttc tgtgtctcaa     2580

gtatctctcc cctttctctt ctgatatcag tcattggatt tagggaccat cctaaaccca     2640

ggataatctc ctcatgagat ccttaggtca attacatctg caaagatctc atttccaaat     2700

aaggtcacat tcaaaagtac caggggttag tcttagactt atctttttgg gggacacgat     2760

tcaacccact accgtgggta acagtggttt tccctcagaa ggtggtggtt caggagtggg     2820

aggaagatga acttttcact gtatatcctt tcaaactatt cacgttttaa aaaaaacatt     2880

ttcatgtaaa tttaaaaaaa ttgaacattc acacaaaaag atgccccctc ccttgcaaaa     2940

aagagtatgc ccgttcaaaa tgttgaaatg tacactcaca gcaatggtgg ctgcagactc     3000

caagtttctg aggttggaga aggtagccag ggagcataaa agtgagttct atctactcat     3060

tcagtctatg aggggaaggc aatggctaga aaagcatttt gagggacagt aaaagtggca     3120

tttttagagg gaggaagcct tgaggatgct tgtggggtga agggaaagaa taactcagga     3180

agaggcattt agggataaga ggaggagagg agatagtgga ggtaggtgat ccctgcggag     3240

gccagattgg ggcaggggag tgtcagctga gtataagagg atggtcccct ctgccctgaa     3300

ggaggaaggc aggaggggaa aaggatgggt gttgacccag aaagcacttg tggtggaggg     3360

gaggccccag aagaggcttc tgacttaccc tgattgctgg tacctctcag gggagctggc     3420

tgcttatttg ctggccaggg tgtgggggaa cccatttgag aagagggaga aggtgacaca     3480

attcctttgg gcaacttatg ggaggggtaa ttggtgaggg atgaaagccc tgccaagtgg     3540

caggaggccc agctggggct gcccctcata agagtgcagt ggaggatatg ggatgagaag     3600

tgactgcccc tctggttcca tctgtcgcag agcccagggt gcttccttcc tcccccacct     3660

ccctcagaac acacccactg catgctggac agcagccccc ttcctgggcc tggggacatc     3720

catgtccctc tgtgcacagg cttcatcatt ctctgggtgc acggtaacga ccccggtagg     3780

tgagaggcca aggtcccaaa ggggagcagc agggaaagtt agctcccatc tattcttgct     3840

ccaggggagg cctttgatga ggaagctgcc aaaagcacat tgcaaataca attccaatta     3900

caggcaacag gaaggagaac cacctctgcc acctctgtca gcaaaccatg agctcctact     3960

ctgtgctgcg atggcgggct cgatggggat aactctgacc ttacctcatg gagtcactgt     4020

caacccactg gttgcactgt ctttgtgcac tggctctctg gagtgaggtc tttgcaaaca     4080

aagtggaaag agcatcaact ttggactcca gcacctagat tcagagcagg ccatttcact     4140

cggaatctgc tgtgcatctg caagggagga tcataaattc gcctttgttt cttcccagta     4200

tcgacagccc ttccagaaag agcaagcctc atgtcatgcc acatgtacaa tctgaggcca     4260

ggagctctct ttcccctttt catcctcctg cctggtacac aataggtgtt tactggatgc     4320

ttgtccagtt gatttcttga acatggtgtg taaaaggaat ctttgcaaat tgaatcttct     4380

ggaaagctga gcttgtgcct accatagaat tctgaatgta cctatatgac gtctttgcaa     4440

acttaaaacc tgaatctttg tagtataaat cccttgaaat gcatgtaggc tggacatcaa     4500

aagcaagcaa tctcttcaag gagcagctag ttggtaaggt cagtgtgcag ggtgcataaa     4560

gggcagaggc cggagggggt ccaggctaag tttagaaggc tgccaggtta aggccagtgg     4620

aaagaattcg gtgggcagcg aggagtccac agtaggattg attcagaagt ctcactggtc     4680

agcaggagac aaggtggacc caggaaacac tgaaaaggtg ggcccggcag aacttggagt     4740

ctggcatccc acgcagggtg agaggcggga gaggaggagc ccctagggcg ccggcctgcc     4800

ttccagccca gttaggattt gggagttttt tcttccctct gcgcgtaatc tgacgctgtt     4860

tggggagggc gaggccgaaa cctgatcctc cagtccgggg gttccgttaa tgtttaatca     4920

gataggatcg tccgatgggg ctctggtggc gtgatctgcg cgccccaggc gtcaagcacc     4980

cacaccctag aaggtttccg cagcgacgtc gaggcgctca tggttgcagg cgggcgccgc     5040

cgttcagttc agggtctgag cctggaggag tgagccaggc agtgagactg gctcgggcgg     5100

gccgggacgc gtcgttgcag cagcggctcc cagctcccag ccaggattcc gcgcgcccct     5160

tcacgcgccc tgctcctgaa cttcagctcc tgcacagtcc tccccaccgc aaggctcaag     5220

gcgccgccgg cgtggaccgc gcacggcctc taggtctcct cgccaggaca gcaacctctc     5280

ccctggccct catgggcacc gtcagctcca ggcggtcctg gtggccgctg ccactgctgc     5340

tgctgctgct gctgctcctg ggtcccgcgg gcgcccgtgc gcaggaggac gaggacggcg     5400

actacgagga gctggtgcta gccttgcgtt ccgaggagga cggcctggcc gaagcacccg     5460

agcacggaac cacagccacc ttccaccgct gcgccaaggt gcgggtgtag ggatgggagg     5520

ccggggcgaa cccgcagccg ggacggtgcg gtgctgtttc ctctcgggcc tcagtttccc     5580

cccatgtaag agaggaagtg gagtgcaggt cgccgagggc tcttcgcttg gcacgatctt     5640

ggggactgca ggcaaggcgg cgggggagga cgggtagtgg ggagcacggt ggagagcggg     5700

gacggccggc tctttgggga cttgctgggg cgtgcggctg cgctattcag tgggaaggtt     5760

cgcggggttg ggagacccgg aggccgagga agggcgagca gagcactgcc aggatatcct     5820

gcccagattt cccagtttct gcctcgccgc ggcacaggtg ggtgaaggag tgaatgcctg     5880

gaacgtactg ggaactgcac caggcacaga gaaagcgggc ttgccattat agtgggttcc     5940

gatttggttt ggaaaacatg ggcagcggag ggtggagggc ctggagagaa ggccctaccc     6000

gagacagggg cggggtggga aggacggcag atgctgggag cacgaggcaa tttctttatg     6060

acacagaact catgctctag tattccatct gtttcagccg aagaaaagaa ccagctgaag     6120

gggcagggga gaaggggcgg aggtattctc gaggcccatt ggcgtccttt aggactcagg     6180

cagggaaggg cccttggtgc tctggagccg gaggtggtgc gcctggtact gggaccccgg     6240

agctgagccc ggcgcctcag cccacctggc tgtctgccga ccgtgtgcgg ggcgagtttg     6300

ctcaacaact ctgccagctt ctggccctca ggctgtggga agcttcttcc cggggcgaga     6360

ccactagctt tttctaagta ttaccagccc aggacttggc tgaggttctg tgtcccccag     6420

cttggagtca gatgtggggt tgaatcttgg cttcctctca ctagctgtgg tgcttgacaa     6480

gtcacttatc cttgagcctc cattgcctaa tctttaaaag ggaggtgaca atcgtcccta     6540

cggctcagtg gcagcagatg gggagatgaa gggaaagttc tgttgaccat gagtgaactt     6600

acaatgcaag ccccgggggg atcacttgca gttttgtccc tgtctgcagt gtgacctgtt     6660

ggtgacattg tctttgctcc aaaccacagc tcctggggca gaggggaaaa ttctgccact     6720

cacagctgcc tgcccacgct tctgtctgag tgtgctgggt ggcaggatgg caagtcctta     6780

ctcagctcag tatagccctc ttccttgttc cctgagcctt tgactttctc gagggatgtt     6840

gtggggttgt ggccaggata agaaagggca tttcaagtta ccactgctcc aaaacaactg     6900

ttctggaaat agtgagtacc ccatcctgag aggtgagtaa gcagaggctg tatgaccacc     6960

tgaaccaagc ccttgaggat gtttcttctc tggtggaagt ttggaacagg agcctcctca     7020

agttcattta ttcattcatt caatggttat tttgtgggaa tcgaatttag aatgaaaata     7080

ttttttggca agcagaaaat aatttttaga ccaatccttt tcttttagtc atgagaaact     7140

gaggcccaga gagaggaggt caccccaggt gcattagaac tgggtttcca gaactgacac     7200

tccactgcac agagtactct cccaattcat tcaattttta tttagcggaa ggcattttca     7260

gatgggtctt tgaagcatta gtaggagttc agcgatgatg gtgtcatgag aattttattc     7320

taggattagg aggtaccatg aacaaagata cagagctggg aaaaccagag gtggaagata     7380

aggagcacat gtccacagtt ctttttcttt tttttttgag atggagtttc gctcttgttg     7440

cccaggctgg agtgcaatgg tgcagtctca gctcactgca acatctgtct cccgggttca     7500

agtggttctc ctgcctcagc ctcccaagaa gctgggatta caggtacctg ccaccacgcc     7560

cggctaattt ttgtattttt agtagagaag gggtttcacc acgttggcca ggctagtcgc     7620

aaactcctga cctcctcagt ggatccgagg aggtgatcct cccgcctcag cctcccaaag     7680

tgctcgaatt acaggtgtga gccaccacgc ctggcctcca cagttcttta tccaccgtct     7740

gaaatgtaaa atgttacgaa aaccaaaagt tttttttgtg atttatttga tggtagcacc     7800

tgacgtgaac tgacatgaga ttatttttaa tttagttgtg tgaatatgca tattcatata     7860

ttttgctgca tagattacag tatgcagctc cagattcttc caagcagact ctgattgccc     7920

attactgcct ttctaaaatc caaacaagtt ctgaggttca aaaccgtttt ggccctaagg     7980

ctttgggtaa agggggtgga ctctgttcta ctctgactgg agtccaagat gcatatatac     8040

agagatatgg gtgatggggc tgcaaggtag gttgaggtag gggccaagga ggagcatgga     8100

gtttggactt gattcatgag gctgtgggga gccagtgaag gttcttaagc aggtatgtct     8160

gcctgagagc agttggagca gacaagagct aaaaaccaaa caaatcacca tagatagtgg     8220

ctgctataat ttgtttgtcc cctccaaatc tcatgtggaa atttggtcct cagtgttgga     8280

agtggggcct aatgggaggt gtttgggtca tgggggagga acccctgtga aaggcttggt     8340

gccgtccttg tgataatgag taagttctcc cgctatgatt tcccttgaag gctgattatt     8400

aaaaagagct tggcacctcc ctctcttctc tcttgcttct tctcttgcca tgtgattgat     8460

ctctgcacat gtaggctccc cttcaccttc tgccatcagt gaaagcagct taaggccctc     8520

accagaagca gatgctggtg ccatgcttcc tggagagctt gcagaatcat gagctgaata     8580

aatccctttt ccttgtaaat tactcacctt caggtattcc tttatatagc aacacaaaag     8640

gactaagaca gtggccttga cttttctctc tctttaagaa gtgttgcctt tgctcactta     8700

gtcatccctt ctgcctgcat ttgtagagca tctggatggg agatttatat aaccgtcact     8760

cttgactttc ccagcaggcc tatgtcatag gtactgtggt ctctacaata cagcagaggt     8820

atctgaggct ccgagaggtt gagtgacttg ctcatggctg cacaaccagt aaatattgga     8880

gctggaattc aggtccacgg tttcctggct ccaaagccca tgattttttc cctcaattta     8940

ttctgactgg ggcatggggg agggggtggc ctttgggcag ggccaccagg agcgaccagg     9000

cccgtagaga gctgggtgca ggtacagagg aaaacctgtt gtcgagtgtg gcccgtagtt     9060

cccatttttg cctgaatggc acatttgaaa gtgttatata accatgtgaa taataatagt     9120

tggcctatat gagttcttta atttgctttt tggtccgcat ttggtaactt ctttatcatc     9180

tactatactc tgttgtgtct cttttgttgt aatttgtaag taggggtgag ataaagtaca     9240

cctagggttt gctgggtttc ttccatgtca tcatgttcct ccttgcatgg ggccaggatc     9300

cgtggaggtt gcctggcacc tacgtggtgg tgctgaagga ggagacccac ctctcgcagt     9360

cagagcgcac tgcccgccgc ctgcaggccc aggctgcccg ccggggatac ctcaccaaga     9420

tcctgcatgt cttccatggc cttcttcctg gcttcctggt gaagatgagt ggcgacctgc     9480

tggagctggt gagccaccct ttttgggaat ggcacttcct gatagggctg ggccactgca     9540

tatacactgg ggactgtgct tagtaggccc attgctgaaa atcagaaggg gacagcaagt     9600

atgtattgag cacttatcgg gtaccaagca cagtaactac tggctttctg tatagaattc     9660

cctttaagcc tggccatgcc ccagtggtac gtctatcttc atttgaaaga cgaggagact     9720

gaagttcaga ggggaccaca cagacagcta ggggtagagc ctggatcaaa cccattggtc     9780

tgcctgccag ccattcttgt gccaatgcat ctgctgccta cggaaacctg tagggacaag     9840

gccctgggat gttcagtgga gcctgagtca ttttataaaa aagcatgact ctagggtcca     9900

aaattccttt gaagctgttg ctatccagag tgaagtccct tctttaggac agggtggccc     9960

tcctccctcc tggatgtcac atcttcggtg gaggggcaga aaggggactg ggtattctcc    10020

tcaccctggc cctagtgctt caaatcttaa aaaaacgttt ttatttgtgc ttctgcacca    10080

ccttctagcc cacctcgttt cctggcctct aacttgatga gagcgtgtgt cattttcaca    10140

ctgattctcc acatggcagg cggtgcttct tagcctcctg cagacagtga ggccccacgg    10200

tcttgtccaa ggtcacacag cgtgtaatgg gcagggtcag agtctggagt ctggacctgg    10260

gtctcctagc tgcactgcac tgctgcccca tgggttaatc agctcagcat accgtggctg    10320

aacagctacc tcataccaag gcctgtggcg ccatgacagg gattgacagg gtccctgcct    10380

tggaaacccg tagtctaagt agaggagact gacaagtcaa tgccttccat cagtctgctc    10440

aacacacgtt taccaagtgc ctactgtgtg ctgcagaggc gaagatgaca cagctcaggc    10500

ctttcccttg agcttacagt tcaggaggag agactgacca gtgactgcca gtacagttga    10560

ctatgggaca atgtgctcag ccttggggag agacgaagaa ggtacccgta tagcaccaga    10620

tgacaggcac gagccccaca ggccagggca gctgctcaga ggagagtagg ccaagcagaa    10680

ggcaaacaga aggctgcagg catttgccat cgagagctgg acttcaaact gggcatcata    10740

ccagcctggg ttcgagtcct gcccagcccc ttattggctg tctaaccctg agcaaatccc    10800

ttcacctctc tgagcctcat tcctctatct gtaaaccagt tataataatt ggaacattca    10860

tttaaggact aaatgaggtc gtgaagcatt cagcagatgc taggtacgga aactcgctga    10920

agtgggggca ggttaagaag cctctgggga tacgaaggca tccagggact agttgtggca    10980

ggaggctgtt accacttagg tctgaagggt aaggagaggg aatagctttc cctctgccca    11040

gttggagccg gtggcatgga ggagaggctg cctgtgggga atcacccgag ggttcaccgc    11100

tgccatgcgc agggagtcag gaggtaggga gggagtgggg cagatgcaca ccattttttt    11160

ttttttttga gactctgttg cccagactgg agtgcagtgg tgccatatct gcacctctgc    11220

ctcccgggtt caagctcact gcaacctctg cctcccgggt tcaagcgatt ctcctgcctc    11280

agcctcccga gtagctggga ctacaggtgt gtgccaccat gcctggctaa tttttgtatt    11340

tttaatagag atggggtttc accatgttgg ccaggctggt ctcgaactct cgacctcagg    11400

tgatccccca cctcggcctc ccaaagtgct gggattacag gcgtgagtca ccgctcccag    11460

ctgctgatgc actcttgtcc ttctaactcc tgctagtgcc tcccattggc tgagcccaac    11520

tggaagcttt gcaagggagc tggtgctgca gtttgcactg agcaggctgg agaaggctgg    11580

agaatagact aggggacaaa ccgaattgcc agtgctgtta tgtcatgatt taggcatgga    11640

gtccagggcc tgagcttcac tccatgtcca tcctgcccag agccttggca cagcctggct    11700

cccagacaag atgtcaagtt cagaatcctt cctaaaagga atcctctatg ccagaccgtg    11760

ttgcagggat atgggagtgc tgggctccca gcctgatcaa ggagcgagaa aactcaggct    11820

cctagtctgt cctccggggc actagcaggg acaaggtggg aggctgctgg gctgggatgt    11880

ggggacaggt ttgatcaggt aaggccaggc tgtggctgtg tttgctgctg tccaaatggc    11940

ttaagcagag tcccccggcc tctctggctt ctgcaggcct tgaagttgcc ccatgtcgac    12000

tacatcgagg aggactcctc tgtctttgcc cagagcatcc cgtggaacct ggagcggatt    12060

acccctccac ggtaccgggc ggatgaatac cagccccccg gtaagacccc catctgtgcc    12120

ctgccccacc ccatctgagc tgaatccatt tgctctgccc tggcctggcc tccctgctgg    12180

tggtttccac ttctcggggg gctttgggac tcagcacctc cactgacccc tttttttctg    12240

tcccatcccc atcccctgca gcccccactg cctgccttcc tgttgcccca caaatgcaaa    12300

agtcttgcct taaatgatcc tcttttcctt cttttctctt gttttccttt tctcaccatt    12360

tggaatggcc cagcaggctg cacttacctt ggaaggaggg ttcatctgat ggtgactcta    12420

cctagggccc ccaggcctct ataactccca gtgccctgca gactggacca gatcctttaa    12480

tgggatagac acaaccctgt ctgggatgcc tctgcctacc ttcctgtttt gctgctccac    12540

ctgcctccag ctccgtttgg cttcctgggg ctccctgcct gggccacttt gtgtcttccc    12600

tctaggcctt tctttccact gttccctctg cctggtgtgg cctggctatg gaagggaggg    12660

aggaggagcg gccatggaaa acggtctgca ttctagcagg gacttgcagg tggcaattca    12720

gtcggggaag actctagatg cacctggcct gaggagagaa tgaagggttc tagttggact    12780

gtgttaagtt tgaggtgccc atggtgtgag gtctggagct cagcgcagag atgatgcaat    12840

gtggtgggtc catgcaacat ggtgccagga cgcagagctt ggggtgaact cagctttcac    12900

cccttaccgg ttctcgtggg atcttgggaa gccactttct tctatgagct ttgtcgttct    12960

tgtctgtaaa atgggcacat aaccctgtcc ctgtccttct cacaggttgc tgtgagactc    13020

caatgagttg aaggatgtgc agatgctttt ggaagtgaaa agttgggggg ctactgtgtg    13080

actttgcata cacccaaact gtgtgacctt gcatatgtct gagttgctgc cattgcaaca    13140

gatcagagct ggtgggctgg gtgtggagaa agggtttgtg tgggggacat cctctggcaa    13200

gggtggcagc agcagaagtg aggggcctgg tcggtcatgt gtgctgaccc ggcctgggca    13260

gcctgtggcc agggagagga cagctcctct gtaggaagag cctgttcctt tccaaccagg    13320

tgagacctct tcagtggagc cctggagccc cctgtactcc acatcagtgc ctcagggacc    13380

tcccggagca ggctaatatc agagaccaag agggacactg gcagaggatc acagagaccc    13440

cagtccaggc agggactgag aagatcttgc cccctaagtt agtttcctag cactgctgtg    13500

acaaattacc accccctcgg ttggaacaag ttgattctct gcagtcctgg aggccagaag    13560

cctgaatcag tgtcggcagg accactttct cccggggggc tccagggaga agcttctctt    13620

gcctcttccg tgtcccaaca gcggcagcac accaatccca gcctctgtct tcacacagcc    13680

ttctctgtgt ctctctcctc ttcattgtct cataaggaca cttgtcattg gatttagggc    13740

ccactggatc ctccaggatg atctcatgtg gggaacctta accacatctg caaggaccct    13800

ttttccaaat aaggtcacag ccacaggttg tgggggttag gatgtgagtg tatctctttg    13860

gcagccactg ttccctcctc tcccttgggc cagaagcaga cgtggggccc tttcttcccc    13920

ataggatgcc catggattgc cccccttccc gcttcccccg agtgtctgtg ggaggtggca    13980

ggaatggcag gcaggggtgt ggaacccctt ctggagtcat atcaagggct tggctggagg    14040

aagtcctcct ggagctgttg ggctggcatg gggcaggctg gctgggccca gcagcagctt    14100

cttcattcat ggggaggcca caagcatggg ccctagagct ggctgccgcc ctcaaaccca    14160

gaccctgcac tcttaactgt gtgaccttgc atacgtcact caccctctct gatcttcagg    14220

ttcctctgca aaagggaggt aatgataacc ctcactctgg ggggctgttt ggagggttaa    14280

atcagttatt gctgtagcat gcatttctct gtcaggtatt gagtgaggtg ctgtgatttt    14340

agccctgcat ttttcttttc ttaccattca ataataacgt tttgagcacc cactgtgcgc    14400

caggcaccat attaggtgct ggggatacaa atgtgaatga aatgaatgtg gtctcttccc    14460

ccaacagtgt atccagaaga ttaatccatt ccttaaacaa atgctacttg acacagatta    14520

gttctggata ggctgagagc tctgaaggag tgcaggcagc tgcgagcctg tgtatccagc    14580

agaaggatca ggaaaggatt cctggaggaa gcgctgttct agccaagacc tacgggggca    14640

ttattaacca ggcaaagggg acggtgtcca agcagtggaa tgaacgtgga ttgaagctgt    14700

gaggcaggag ggagtgtggc ctgtgcagaa gggaccgagg ctggtgagac caggagggcc    14760

tgggtggcct ccaggtcaga tgtgaaagga agaacttggc cacagtctga gcttctcagg    14820

cgtatggcag ggctgcctgg tgagagggaa tgagctccct gctctggagg tatgcaagca    14880

ggactgggct ctcacctgcc agaggccaca gagctttcca gaggctggaa gaggccactc    14940

caaggcctct ttgcccctga gagtggtggc tcttcttgag gccaccttgc cacgctgtca    15000

cagggaacta gcagcccctg cctcacccgg gggtttggaa gatagaggga ggcctaggaa    15060

gggccctgtg tctcatccga gctgggcccc tttccagcct ctcactggaa ggaagcccaa    15120

ggatgttcct gtgggggctt ttaccaggcc cacctgccct ctgctggcca tgcttgcagc    15180

ctcctgaccc tgtcccagca ggacagtggg ctggtgtgag cgggcaggaa ccgcctgcac    15240

ttagaaggtg tggggctgcc tccccgagct tccatctgcc gctggggcca caccccaggc    15300

ccagggatgg gaccccacag tggtcacatc atcttgcagc agaacccagg tacagctcct    15360

ggagcagatg gtggtcccaa gcacgggtgg gaccagaaag gactctcacc tgggctaact    15420

cagctgcagc ctcagttccc tcctcacaca cgacgaggaa catggactgg aagcctgccc    15480

agcaggcctt ctgctcgatg tgcgttgtgt ggcttacgtc cagggaggga agcagcctct    15540

gtgctgtctt ctagataagc ctgtattccc cgggctgtct gccaatgtat ccagttgtcc    15600

cgtcagcctg gaagctctga gggaaaacct tgggctgctt cctgagcacc tgtatcccct    15660

gcagccagcc cggggcctct gctaggagca gactgagcat ggcttatggg cctggcacca    15720

tctggcctct gcccaccttg ctggccttgt cttgtgtctg ccccttcgac attccatagc    15780

ccagctcaat atctagtggt tcctctaggg tggcgagcac tgtttggtct ccagatgtct    15840

tcaggtcgga gctcacagcg ctctcagcca ccccttccca gtgtagcacc gggcacatgg    15900

tagatgccta ttgatgagtg aaagctccta acacactcag agagcaagga ctccgcctca    15960

tcccacagcc tgggaggaga ggcagactgc caaggacctg ctcagcatgc tacagaagaa    16020

accaaagtgc ccacgggact gatcagtgga gcttcctgcc gagactggag gccttagggc    16080

agggtagaca gtgtgtgtgc aggctgggga ctcacagttc ggactgtgcc cagacctact    16140

agcatagtgg gtgggtggga ggatgcggga ctgggggccg accttgcctg aaattcatgt    16200

gggatctcag agcagccact gaattgctct gtagggggct aaatagtggc ccccacagat    16260

acacacaccc agacagagcc tgtgagccag accttatttg gagaaaaggt ctttgtagat    16320

gtaattaagc atctcaagat ggcatcatct ggattatgcg gtgggctgta agtcctgtga    16380

tgtgtcttta tgagagaaag gcagagggag atttgacaca cacaggaggg gccacgtgga    16440

gacagaggtg gagattggag aaatgtggcc acaagccagg gaacaccagc agccaccaga    16500

agccggaaga cgtgaggcag ggttcttccc agagccttcg ctgctgagtc tgggaatttg    16560

tgaccgaagc cataagaagt gggtacacgc cctgagcctc ccacacttgc tcacctgtcc    16620

tgagatgaga atctctactc tgcagcatat ttggaggatc actgcggggg ccacagaggt    16680

gctgttcaga tggcacttca gaagactcag gagaccctgg ggcaggagca gtttgactga    16740

cagcccagag ggctgccctc tgattccacc tgaggccctg cttttcctgg ctgcaggggt    16800

tccagggcca ggccatttcc gctggcgcag gactctgcta gcagcaacct gcctgaagtc    16860

ttcctttggc ctggctgaga gtttctgaga cctgcgctgg agcggaggtg cttccttcct    16920

tgcttccttt cttcctctct cccttctcca tccagcaggc tggacctgcc tggcatctgt    16980

gagctctccc tactttctcc tataccctaa cctttgtcct gcatgggcga ctcccccagt    17040

gagtctcttg cagcttttac cccagtgcct gcttcttgga gaatccaaac tgatccagtt    17100

agggatgata aagtgtaggg taggcgctcg gtgactgttt tctctgaggt tgtgactcgt    17160

gtgaggcaga agcagtcccc gtgagccctc ctggtatctt gtggagtgga gaacgcttgg    17220

acctggagcc aggaggccca gacatacatc ctgtccgagc tgcagcttcc tgtctctaaa    17280

atgagccggc cagcgcaggt ggccagacat cactgttatt ctcctttgag tctttaaatc    17340

ttgttgtctt tcttgcagac tcggtgagct gtgaaaggct ataatagggg ctttatttta    17400

cactttgata ctattttttg aacattcata ttattgttag atattgatat tcatatgaag    17460

gagcaggatg acttgggtcc ttcttggcag tagcattgcc agctgatggc cttggacagt    17520

tacctgccct ctctaggcct ccctttcctt gtctatgaaa tacattatag aataggatgt    17580

agtgtgtgag gattttttgg aggttaaacg agtgaatata tttaaggcgc tttcaccagt    17640

gcctgggatg tgctctgtag tttctgtgtg ttaactataa ggttgacttt atgctcattc    17700

cctcctctcc cacaaatgtc gccttggaaa gacggaggca gcctggtgga ggtgtatctc    17760

ctagacacca gcatacagag tgaccaccgg gaaatcgagg gcagggtcat ggtcaccgac    17820

ttcgagaatg tgcccgagga ggacgggacc cgcttccaca gacaggtaag cacggccgtc    17880

tgatgggagg gctgcctctg cccatatccc catcctggag gtgggtgggg actgccaccc    17940

cagagcgttg cagctgtact cctgggttgc acccccccca gctgtcactg tcccctccct    18000

gccatcagtt gtgggaaggg cgttcatcca tccagccacc tgctgatttg ttatagggtg    18060

gagggggggt ctttctcatg tggtccttgt gttcgtcgag caggccagca agtgtgacag    18120

tcatggcacc cacctggcag gggtggtcag cggccgggat gccggcgtgg ccaagggtgc    18180

cagcatgcgc agcctgcgcg tgctcaactg ccaagggaag ggcacggtta gcggcaccct    18240

cataggtaag tgatggcccc agacgctggt ctctctccat ctggacctgg cctgggaggt    18300

ggcttgggct gggcccaggg agagctaatg tctcctaacc aagaatgctg tggcagcctc    18360

tgccgcagag ccagagaacc agagtgccaa ggctggcagg gttcccagtg gccacgagtg    18420

cagatgaaga aacccaggcc ccaagagggt catgcaggta gcccagggag ttcagccttg    18480

accctgggtc aatgaccttt ccacagttcc acactgctcc ccttttaaaa tccggtgatg    18540

tctttatgtc ttttgttatg ttatcttcaa tgtggaggga ctcgaggtga tctaagcaaa    18600

ctttttctat cttctgcttg catacctctg agaccagggg actcactcac ttgcatgact    18660

gggccctgca ggtcacactg gccaggcaga tgtggtggag gaactggcag aggacttttt    18720

ctagactgtg actacattta gtccacccag cggcccccct atgaagtcca gttgagaact    18780

aggactctgg gggccggtgg acagagaaga gggagggttc tctcccttac tgacttcctt    18840

ctgtggccag acattgagca aggcctctgt acagcatgtc ctggggctgg ccttgccgta    18900

gctgctaaat agttgacgaa accagtccag agaggggagg tgactgccag ggtcgcacag    18960

ctcaagctgg ggaactcgct gggaaaactg tcagctctgg gcagcagctt gacttccact    19020

gtaagcccca gcccccaggg tcaaacactg gctctggtgc tggcagaggc agcccactag    19080

cctgtttcaa aggctgagaa ggcccaggag tctgccctgt gctccaccag ttctgccctg    19140

agactttcct acagagtaca ggttttgatg ttcagtttta aaggcaagaa tcaataacct    19200

tctgccccat caggtgaccc cttgtgcctg tcccacccct ttattgactg acctcggctc    19260

agtcaggtca gttcctgaag gtcagtgtgt ggaggggagg ctgttctttc ccagaaaggc    19320

cttccccagg cctggtgctc tggcctctgg aggacttcct ggagaagtcc cttctttggg    19380

gtcccagtca gtgtatggga agcccttatt gcatgacctg gcacggggca ggggctcaac    19440

agtcactatt gccttccttg ccactgccat ttcctcctct gtaagcaggt gattgtgtgt    19500

ccagtctgag cacagagata agcacacagc aggtgcttaa taactagcag ctgtaggctg    19560

ggcgcggtgg ctcatgcctg taatcccagc actttgggag gccgaggtgg gcagatcacc    19620

tgaggtcagg agttcgagac cagcctgttc aacatggtga aaccccgtct ctactaaaaa    19680

tacaaaaatt agccaggcat ggtggtgggt gtctgtatcc cagctacttg ggaggctaag    19740

gcaggagaat cgcttgaacc caggaggtgg aggttgcagt gagctgagat cgtgccactg    19800

caatccagcc tgagtgatag agcgagattc catctcaaaa ataaataagt aaataactag    19860

cagctgtaaa tgtggctgtt gttcttcacc tccacactca gtgccactcc actccctccc    19920

tccgtggtgt gaggggcctc actagctgtc tcctaggagg agcatggctg tgagattcca    19980

gctccatcct tggccacggc tcctggagac atcttagagg ccaggatcca gaaggctccc    20040

acacctcatt tgacagggga gaagctgtca gttccaggtc cccttgcaca tcagggccag    20100

agctgcgtta ggcctccagt ctccaggcca ctgggccaga gctcacaggc tggcagaggg    20160

ttagaactgt tactggtggc tgggtgcagt ggctcacgcc tgtaatctta gcactttggg    20220

agggcaaggc gggaggatca tgaggtcagg acatcgagac catccttgct aacacggtga    20280

agccccgtct ctactaaaac tacaaaaaat tagccgggcg tggtggcagg cgcctgtagt    20340

cccagctact caggaggctg aggcaggaga atggcgtgaa cccgggaggc ggagcttgca    20400

gtgagccgag attgcgccac tgcactccag cctgggcaat agagcgagac tccgtctgga    20460

aagaaaaaaa aaaaaaagag ctgttactgt tgacagtagc atgaggtaga ccatggcctg    20520

caccaaaatg ggggagtgga gtgccactga ggccagaagg aaccacaccc tcaagggtgg    20580

ggagttatgg tatggggggt cctaggcatg gagtctttta attctttaga caatcctggg    20640

agcaactgtc cctgtttcac agagggcggg gccacacagc tggtgagtgg gcagccaaga    20700

ctctgttcaa gtttgtgtgg gtccaacact tgcggccacg gtggaggggc atctgagcca    20760

ggcctcagag agtggcgggg gaagttgggt ggggaagtgt gcccttctca ttcctctgag    20820

gctcatcctc ttggtgcctc tctttcatgg aaagggataa taaggttatt gtgaggatcc    20880

cctgagttcg tatattcaga cgcttagaca gagccaggca cagagaaggg cccggggttg    20940

gctagtttga ttgctggtgt aattgctaat atcttccagt ttgtattggt caaggttctg    21000

cagagaagca gaaccagtag gatgtatata ttaagagttt caagctcatg tgaccgtgcg    21060

ggctggcaag tctgaaatcc gcagggcagg ccaggcaggc tggcaattcc tgcagaattt    21120

gatgttgcaa tactgagtcc taaggcagtc ctggggcaga attccttctt ccctgggagg    21180

cctcagtctg ttctcttaag gccttcaact gattaaatga ggcctgccca agttatagag    21240

agtaacctgc cttactccgt cttctgattt aaatgttagt cacatctaaa aaatattttc    21300

gcagcagcat ttccactggc ttttgaccaa acatcaggcc acaaagttga tccccaaaat    21360

taaccatcac tctgtgcctg taagggaggg gctgggaaag gggagcaggt ctccccaagg    21420

ggtgaccttg gctttgttcc tcccaggcct ggagtttatt cggaaaagcc agctggtcca    21480

gcctgtgggg ccactggtgg tgctgctgcc cctggcgggt gggtacagcc gcgtcctcaa    21540

cgccgcctgc cagcgcctgg cgagggctgg ggtcgtgctg gtcaccgctg ccggcaactt    21600

ccgggacgat gcctgcctct actccccagc ctcagctccc gaggtaggtg ctggggctgc    21660

tgccccaagg cgcgggtagg gggcggaggg cggagggcgg agggagggcg ggcgggcagg    21720

cgggcttctt gtggcacgtg ggcttcttgt ggcacgttcc tggaggccga acccttctgg    21780

ctttggaagg agtcgtcaga gacccccgcc atgcgggagg ctggggagga aggggctcga    21840

aacctccatc atcgcagagt ctgaatagca gtggccccgc catgcgccca cgtagcggcg    21900

cctacgtagc cacgccccca caccccgtcc tggccactct ccctcctgaa ggtcttctgg    21960

tacccgcccc ctccccatct ccatccccag gccctgcgtc ctctgcccaa tactctttgg    22020

gcctccctgt tgtccagctc tctccgcggc tccatgactg acaacttgag caaggctaat    22080

gtgaatggga gcggttgagg gctcagacct ctcacccgag gaacatccac agagtgtgcc    22140

gcatgcccgg tgcagtgtgg ctgcggggac acagacacgg agcctcggcc ctgaggagct    22200

ggggggcagt gaccgtccct cctctgaccc accactcctc cagtgtcagg acactgcggg    22260

tatctagggg aaggaatctt gttccacttc aagtctggaa cttcaagtct gtgtgtgtgc    22320

gtgcgcgcgc gcgcgttggg ggtgggggtt gcagagcaga tgcgtacctg acagcggtaa    22380

cctaggtccc ccctggccta tcaaggcttc cctggcggcc gaatttaaag gcatcaagca    22440

aacaaagccc aacacatctc tgccttgtcc tctcagtttc cccccgtggc acttagaacc    22500

acttgataca ccgaatagtt tcctatctcc cccactagga tgtaaactcc acaggggcat    22560

tgggaatgct gcctggctat ggtagggaca gaggggagca ccagggcggg gcaggggtgc    22620

cagagttctg cctgggcagt cagattttcc ttaggagggg acatttgagt gggacccaaa    22680

caggtgtata gcagttgtcc agcccagctg gcaaggcctg agtctgcctc tgcaacccct    22740

ctcttgggct cctttctctg ccacccacct cctcaccttt ccaggtcatc acagttgggg    22800

ccaccaatgc ccaagaccag ccggtgaccc tggggacttt ggggaccaac tttggccgct    22860

gtgtggacct ctttgcccca ggggaggaca tcattggtgc ctccagcgac tgcagcacct    22920

gctttgtgtc acagagtggg acatcacagg ctgctgccca cgtggctggt aagtcaccac    22980

cccactgcct cggccaccgt gatgctaaca gcccctttgg cagtcagggt ctgtgccggg    23040

acctccagtg ccaggctctg tgcaggggga ccagagatga agtaggcctg atggtgcctt    23100

caaggacact cagtctgatg agggaggcga gtgcacagag gaaacacgag gtcagggctg    23160

tattagaggg agcccagagg aggcacctgc ccagcccgag ggtcagagaa ggcatcttgg    23220

aggagggaca tttgatcggg agcttgatgg atgaatagga gttcacctgg ccgataagac    23280

agcaactacc aaggcttaga ggtgtgagag gaggctgtct tacctcactg agtaaggact    23340

gcaggcggct taccttcgag aagagagctt agtgtctgtg tgcacgtgtg tttgtgtgta    23400

tgtgtgtgcg tgtgtgcact ggcaggagtc ccctgctggg gcaggagggc cgggccatca    23460

ccatctttca ccattcaccc ctgcaccagg cattgcagcc atgatgctgt ctgccgagcc    23520

ggagctcacc ctggccgagt tgaggcagag actgatccac ttctctgcca aagatgtcat    23580

caatgaggcc tggttccctg aggaccagcg ggtactgacc cccaacctgg tggccgccct    23640

gccccccagc acccatgggg caggtaagca ggatggcagg gtgggcaagt ccaggctggg    23700

gcttgggagg tctgtgtgac cttgacagtc tctcccttct cccttgtctg tgtaaggagg    23760

atgacgccac cttaaatagg attaaatgag aatggggctc tgaaagggct gtgcaatatt    23820

ttcataacgt gtttttatag agacagttga gtatgttctt taagccctcc tctctcctac    23880

catgaactaa agatttctgt ggaggtcccc tcactcccag caccccctcc tcatcccagg    23940

ccctttttgc aggttggcag ctgttttgca ggactgtatg gtcagcacac tcggggccta    24000

cacggatggc cacagccgtc gcccgctgcg ccccagatga ggagctgctg agctgctcca    24060

gtttctccag gagtgggaag cggcggggcg agcgcatgga ggtgactgta cccctccttc    24120

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtcagtgctg    24180

ggccctcagg gacccccagc aagcccctcc atcctccaga ctccagctct tctgtaagct    24240

tacagggctg gccagaccag gagtggggca ctcctcactt cacgcggctg ggggctgctg    24300

gagagagcca cagcgggaag ggtttcctag aggctgcagg acagtgctgg atggattttc    24360

aatgctcacc tgggtgtgag cgtgcggcag ggccgcgtga gggtcagcga tctgctactc    24420

tggactcagc catctctagg cccctctcac tcaggtgctc catggttctg ggagctgaga    24480

aatctcaaac cagcaaaaaa gtggaattga tgttgatgct acaggatagt gcacagatgc    24540

catctggttg cagcattttg gtggaagggc agtgcccagc taggagagtg aggaggggca    24600

ggcatttctg gcttgaggag atggggtctt aatgctcgtg tgagaggcag agtgggtgga    24660

gtggagctgg ctggatcctt gctttggcct cctggatttc tctctatctc cattttgaaa    24720

ccactctgtg tttggaagaa cttttgagta ttcagagctg cccactggca gaacagtctt    24780

ccttgggcag gagtgagctc cttgtcccca gaaggctggg tctggctggc ccctggcagg    24840

gacactgatg agggtgcttg agttgatcct gtctagtccc tttctgtgtt ttcaaagccc    24900

attctaaagc agattcccat ttccgtcttt gactctaagg cccaaggggg caagctggtc    24960

tgccgggccc acaacgcttt tgggggtgag ggtgtctacg ccattgccag gtgctgcctg    25020

ctaccccagg ccaactgcag cgtccacaca gctccaccag ctgaggccag catggggacc    25080

cgtgtccact gccaccaaca gggccacgtc ctcacaggta ggaggctggg cttgccctgg    25140

ggtgaggagg ggtctctttc tccttatgca cccactgccc gcgaggcttg gtcctcacaa    25200

gtgtgatcca tgagactcaa gcctgacttg cagttccata ctctggttct gccacttcca    25260

tgccctttga gcctgggcag gtgaccttac ttctcctcat ctcagcttcc tcctccataa    25320

gagggaaaaa ggtattacct gcctcattgt gttgcaagga gatgggcagc atctagggca    25380

ctggcctgga gtatcgcagg tgctttgcct aaggtggtgc agtccaggag aggcagctcc    25440

agagagaggc ccccggctgg ggctgaaagg agggcagacc tcggtttgaa tttcaccctg    25500

ccgctctata gctgtgtgac ttgggcaaat tacttaacat ctctgtatga ggaaatgatg    25560

agtgctaagc acttagctta gtgccgggac aatataaatt ctagctatcg ttactattgt    25620

tttcatcacc cgttgcttta aaatccagcc tctggtatag gcaactattg acgggctacc    25680

ctgtgtcgaa aacatgccca ggcaggtagc aggaagtcac agatggggac ctcttggggc    25740

atcaagggat ggtgccctga ggctgagctg ttctggttgg gtggagcatg agaggtctgg    25800

gaagacagtg ggactccagc ctggaataag aggctcagag ttgattctcg tctgagcacg    25860

tccaggggaa ccactgaggg tttgggaaca ggagagtgag ggtgagaacc tggttctggg    25920

cacagcaggc tggcatgtag gatggatgtt caggaaagat gagcatagtc aggtggctgg    25980

tgcccttgtc caggggagag gctccgtcag gttcaggggt cctggcttgg agggaagtcc    26040

gccatgctct aatcacgctc ccctttggaa gtgctcagcc gatgagctca caggcacatg    26100

tcagtttgaa gtcatggaat ctgactccat gaagcgcacc tcaaagagca ccattttgca    26160

gctaagggaa ctgcaggctg gacatgctga gtggctgccc cgagcccttg cagctaggac    26220

atagagaatg ctagtaacca caaccctacc atgttcagag cacatgccag gctccatgct    26280

ggggcttcgc acgtgtcatc ttcacagtgt ccctgtgagt aggtgtggtt tctctttcca    26340

tcttacaaat gagtaaacag agcctcagtg tagctaagta accactattt taggtttctt    26400

agccaatggg tgtgtctgac tcctaagccc atggagggca ttctgaggtg gttcagacag    26460

accccggctt acccttgaac ttctgcctgc tggctgcata gggaggggct ggggggagtt    26520

tgagcatctc aggccataga gcccctgcct cactgtctcc atctctgggt ggaaagatgg    26580

tgttttccct gagaaactaa ggctcagaga ggttgaatgg ctctcccaag gtcacacagc    26640

tggtcagctg cagagttgag aacacaggag tcctggtgct caggccagca tctctttttt    26700

tctttgagtt gtttctaggt ttcctagctc ttgcctcaga ccttaaagag agagggtctg    26760

atggggatgg gcactggaga cggagcatcc cagcatttca catctgagct ggctttcctc    26820

tgccccaggc tgcagctccc actgggaggt ggaggacctt ggcacccaca agccgcctgt    26880

gctgaggcca cgaggtcagc ccaaccagtg cgtgggccac agggaggcca gcatccacgc    26940

ttcctgctgc catgccccag gtctggaatg caaagtcaag gagcatggaa tcccggcccc    27000

tcaggagcag gtgaagaggc ccgtgaggcc gggtgggtgg ggtgctgcgt gtctctcctg    27060

cacagctttt ctgtgtcagt ttgtgccacc accataccgc catgcatcag ggtggcggtt    27120

tgccaggtag atgctgtggg cagcttccgc cattgtgtgg acagcatgta tatgtgtctc    27180

tgtgtggctg ggtctgtttt tgcttttgtc cagatcagta aggtttgcta cctgggtacc    27240

ccactccact tggagtagaa tgtgcataaa tatggcataa agaaatgcaa tatgcatgca    27300

tttattgatt gatctatttt tttctgagat ggggtcttgc tgtgttgccc aggctggtct    27360

caaattcctg ggctcaagca atcctctggt ctcagcctcc ccaagtgttg ggattatagg    27420

catgagccgc tgcacctggc ctctctgatc tatttaacaa acctgctggg agggtctcag    27480

ggtcaggagc agcactgggc tctgaggaca cagagctcac tcagccgtga cccagagggg    27540

gtgcctgagc tgcatgctga aggttgttag catgaccagc aaggcaagaa aaggccctgc    27600

cgagattagc aaggcatgtg ccaagccctg gaatgtgaca gccgggcctt ctagaaacct    27660

gagtgtataa ctctccttaa aagccagtag gagctcctca aaaggcagcc ctaaggagtc    27720

cactcttaaa tgaactcaga gtcagtttta aaatgcaagt ctgtgttgat tctggtctgg    27780

atggtgcatt cctcgagagc aaaagacagt cttggtcttg gatccacttg ccctgggtac    27840

actgagggct gctaggttcc aggtgctctt cctggcactg gggagggata caggcccaag    27900

agacatgctg ttctccctcc tggagcatct attttagtgg aggaagacag aaaacaaacc    27960

attaatatag agtactgaaa agatgcgatg gagaaaacta tagcaaggaa gggaatgggg    28020

tgggagagag gtcaggagag gtctcgctga caaggtggac gaaacaggcc atgaggcaga    28080

gaacatgttc caggcaaagc aaaggccccc aggtggggat gtgcagggag taccaggaaa    28140

ccagagaggt gggaatagtt atgagatggg gggtgcctca gaggggacag ggccaagtca    28200

ggtgagacct gagggtcaca gtcagcagtg agctggggcc atgcaggggt ctggcctcag    28260

aggagtgtgg tctggcctgg atctgaacct ctcactgtgg cctagctgct gagctgagaa    28320

gagatgacaa ggaccttggg cagaagcagg gagactggag ggaggcggtg gagggtccag    28380

gcgttggggc ggggctcagg ctggagtctg aagggagcct gcaggcctgg tgggtggatg    28440

tgggtgggag agggggagga tggcaccaag gctcgggccc ctggacagat ggagttgcca    28500

ttaagtggga tggggcaggc tatggggcca tcagtttcag agggatgagt ttggcactgg    28560

catggtaggc atctgtctat ctccacggcc ctcaaaccag gcatgaagca ggagctcacg    28620

tgtttggtca gccatggtgc agaaccgcct gggtgggagg tgcggggtgg gagatacacg    28680

gttgtgtccc aaatgggctc tgagccagcg agggccgtct gcactttggc ctcacagaag    28740

gatgtcggag ggagaaatga agtgtgggtg ggggtcccgg gccacgctag acatgtgctt    28800

tcttttcctc gggctctggc aggtgaccgt ggcctgcgag gagggctgga ccctgactgg    28860

ctgcagtgcc ctccctggga cctcccacgt cctgggggcc tacgccgtag acaacacgtg    28920

tgtagtcagg agccgggacg tcagcactac aggcagcacc agcgaagggg ccgtgacagc    28980

cgttgccatc tgctgccgga gccggcacct ggcgcaggcc tcccaggagc tccagtgaca    29040

gccccatccc aggatgggtg tctggggagg gtcaagggct ggggctgagc tttaaaatgg    29100

ttccgacttg tccctctctc agccctccat ggcctggcac gaggggatgg ggatgcttcc    29160

gcctttccgg ggctgctggc ctggcccttg agtggggcag cctccttgcc tggaactcac    29220

tcactctggg tgcctcctcc ccaggtggag gtgccaggaa gctccctccc tcactgtggg    29280

gcatttcacc attcaaacag gtcgagctgt gctcgggtgc tgccagctgc tcccaatgtg    29340

ccgatgtccg tgggcagaat gacttttatt gagctcttgt tccgtgccag gcattcaatc    29400

ctcaggtctc caccaaggag gcaggattct tcccatggat aggggagggg gcggtagggg    29460

ctgcagggac aaacatcgtt ggggggtgag tgtgaaaggt gctgatggcc ctcatctcca    29520

gctaactgtg gagaagcccc tgggggctcc ctgattaatg gaggcttagc tttctggatg    29580

gcatctagcc agaggctgga gacaggtgcg cccctggtgg tcacaggctg tgccttggtt    29640

tcctgagcca cctttactct gctctatgcc aggctgtgct agcaacaccc aaaggtggcc    29700

tgcggggagc catcacctag gactgactcg gcagtgtgca gtggtgcatg cactgtctca    29760

gccaacccgc tccactaccc ggcagggtac acattcgcac ccctacttca cagaggaaga    29820

aacctggaac cagagggggc gtgcctgcca agctcacaca gcaggaactg agccagaaac    29880

gcagattggg ctggctctga agccaagcct cttcttactt cacccggctg ggctcctcat    29940

ttttacgggt aacagtgagg ctgggaaggg gaacacagac caggaagctc ggtgagtgat    30000

ggcagaacga tgcctgcagg catggaactt tttccgttat cacccaggcc tgattcactg    30060

gcctggcgga gatgcttcta aggcatggtc gggggagagg gccaacaact gtccctcctt    30120

gagcaccagc cccacccaag caagcagaca tttatctttt gggtctgtcc tctctgttgc    30180

ctttttacag ccaacttttc tagacctgtt ttgcttttgt aacttgaaga tatttattct    30240

gggttttgta gcatttttat taatatggtg actttttaaa ataaaaacaa acaaacgttg    30300

tcctaactct tgcatagact tgactgccta gggtgatgcc ttgcttatac taggaactgg    30360

gtaagtttgt tgaatagttg agtaagccaa gtatttgatg agtactttta tcttgagtac    30420

aagtattggg caagtactgg tgatgtgaac ttactccttg tgcctatcct aggaatgaaa    30480

tgaatgtctt cctgcagctc ccctgaccac cctgacagtc aaagtgcctc ctccttggtg    30540

acaggtgccc tacagcactc tagatgctct gttgtcctga cctcccaatg cccttttcat    30600

tcttttctcc ccagtacctg gcacacagcc tggcccgagt atttacggaa taagttacag    30660

tgccagatgc ttctgtaatg agccagtgct aagtccatgg cttttttcat gatttaaaat    30720

tcagaacagt ctcagattgg gtgcaatggc tcacacctgt aatctcagta ctttgggagg    30780

ctgaggcagg aggattgctt gtgtttagga attcaagacc ctgggcaaca gtgagacccc    30840

gtctctataa aaaaatttaa aagattagcg aggtgtggta gcacatgcct gtggtcccgg    30900

ctactcagga ggctgatatg ggaggcttgc ttgagctggg aggctgaggg tgcagtgagc    30960

tgtaattaca tcatcactgc actgcagcct gggttacaga gtgcataatg atcccattca    31020

atgtgggacc tccaggccct ccactctaag gctggtgaat atagctgtct taagcaagtt    31080

ctctctctct ctagacagcc catgtcataa ggaatctcag gcaaaattcc tcccagatta    31140

cattttctga caattcagtg tcatatatgg aaagcattca agagttgaca gatggcaatg    31200

gcttgaacac ccaactgtgt tatctctgcc cgttggaacc taggcctgtg gtgcaaccct    31260

agactctctc tccttcccct ccacagaatc aagtatcagc tggttagaga tccacaccct    31320

gacagctctg tgatgttgga acaacttggt tcttgcagag ggttagcagg tggtcaccag    31380

ggatcgggga ggaaggggtg tggcttgcag gaaggcgaaa atctggacta gcaaataggg    31440

aaggggaccc atgtgagcaa cgctggccac taggaatgag actgagacct gtgggatcta    31500

gcaagaagcc cagtgtgacc agcgacacga tctatgctgg ggaccacttg ggagagccaa    31560

aagctttggt ggagatgaat ggagaccatc aacctaagtt cagcatcctc ctctaagctt    31620

tgcagatgaa tcctgaaatg gtcagcccct ccagagaaaa gaacagcaac aggctcagag    31680

gacccacagt cccctttatt agtgtaaagt actaagagga atcaacagca tttagcacca    31740

ggcacaggct cgtgttcccc cgcccactac ggctgtgttc tgatatatga agaatggcgg    31800

caagactcca actctgtttt tgaaaaattt attttatact cttagaagct aagaactttg    31860

ccacacatga accaaattta gaattaaggt tcttccctag tgtatctact tccttttgaa    31920

attttataaa caagatttta tacacaagag gtagcagagg aaaattccag tctgcttgtt    31980

ccaagctcag aaggtaactg cacacacctc gatgttagca gggaaggtgg ggcaggacag    32040

ggtaagtctg atgatacggc actctagttc ctaaaactga ctgtagttgt cagtgaccgt    32100

gtgaggactc caggagaagt cgtggtgaga tgcccgctgg gatgcttgtt ttctttccca    32160

ggatgccttc aacgggcaga atcggccatc ttaagatcgg cctcactaag ggagcttctt    32220

gagaacacac agcattattg agttaattgt gcaattcctg ctctgtttgc agaccatttt    32280

gaaaggttta taaaaacatc ttca                                           32304


<210>  2
<211>  3731
<212>  DNA
<213>  Homo sapiens

<400>  2
gtccgatggg gctctggtgg cgtgatctgc gcgccccagg cgtcaagcac ccacacccta       60

gaaggtttcc gcagcgacgt cgaggcgctc atggttgcag gcgggcgccg ccgttcagtt      120

cagggtctga gcctggagga gtgagccagg cagtgagact ggctcgggcg ggccgggacg      180

cgtcgttgca gcagcggctc ccagctccca gccaggattc cgcgcgcccc ttcacgcgcc      240

ctgctcctga acttcagctc ctgcacagtc ctccccaccg caaggctcaa ggcgccgccg      300

gcgtggaccg cgcacggcct ctaggtctcc tcgccaggac agcaacctct cccctggccc      360

tcatgggcac cgtcagctcc aggcggtcct ggtggccgct gccactgctg ctgctgctgc      420

tgctgctcct gggtcccgcg ggcgcccgtg cgcaggagga cgaggacggc gactacgagg      480

agctggtgct agccttgcgt tccgaggagg acggcctggc cgaagcaccc gagcacggaa      540

ccacagccac cttccaccgc tgcgccaagg atccgtggag gttgcctggc acctacgtgg      600

tggtgctgaa ggaggagacc cacctctcgc agtcagagcg cactgcccgc cgcctgcagg      660

cccaggctgc ccgccgggga tacctcacca agatcctgca tgtcttccat ggccttcttc      720

ctggcttcct ggtgaagatg agtggcgacc tgctggagct ggccttgaag ttgccccatg      780

tcgactacat cgaggaggac tcctctgtct ttgcccagag catcccgtgg aacctggagc      840

ggattacccc tccacggtac cgggcggatg aataccagcc ccccgacgga ggcagcctgg      900

tggaggtgta tctcctagac accagcatac agagtgacca ccgggaaatc gagggcaggg      960

tcatggtcac cgacttcgag aatgtgcccg aggaggacgg gacccgcttc cacagacagg     1020

ccagcaagtg tgacagtcat ggcacccacc tggcaggggt ggtcagcggc cgggatgccg     1080

gcgtggccaa gggtgccagc atgcgcagcc tgcgcgtgct caactgccaa gggaagggca     1140

cggttagcgg caccctcata ggcctggagt ttattcggaa aagccagctg gtccagcctg     1200

tggggccact ggtggtgctg ctgcccctgg cgggtgggta cagccgcgtc ctcaacgccg     1260

cctgccagcg cctggcgagg gctggggtcg tgctggtcac cgctgccggc aacttccggg     1320

acgatgcctg cctctactcc ccagcctcag ctcccgaggt catcacagtt ggggccacca     1380

atgcccaaga ccagccggtg accctgggga ctttggggac caactttggc cgctgtgtgg     1440

acctctttgc cccaggggag gacatcattg gtgcctccag cgactgcagc acctgctttg     1500

tgtcacagag tgggacatca caggctgctg cccacgtggc tggcattgca gccatgatgc     1560

tgtctgccga gccggagctc accctggccg agttgaggca gagactgatc cacttctctg     1620

ccaaagatgt catcaatgag gcctggttcc ctgaggacca gcgggtactg acccccaacc     1680

tggtggccgc cctgcccccc agcacccatg gggcaggttg gcagctgttt tgcaggactg     1740

tatggtcagc acactcgggg cctacacgga tggccacagc cgtcgcccgc tgcgccccag     1800

atgaggagct gctgagctgc tccagtttct ccaggagtgg gaagcggcgg ggcgagcgca     1860

tggaggccca agggggcaag ctggtctgcc gggcccacaa cgcttttggg ggtgagggtg     1920

tctacgccat tgccaggtgc tgcctgctac cccaggccaa ctgcagcgtc cacacagctc     1980

caccagctga ggccagcatg gggacccgtg tccactgcca ccaacagggc cacgtcctca     2040

caggctgcag ctcccactgg gaggtggagg accttggcac ccacaagccg cctgtgctga     2100

ggccacgagg tcagcccaac cagtgcgtgg gccacaggga ggccagcatc cacgcttcct     2160

gctgccatgc cccaggtctg gaatgcaaag tcaaggagca tggaatcccg gcccctcagg     2220

agcaggtgac cgtggcctgc gaggagggct ggaccctgac tggctgcagt gccctccctg     2280

ggacctccca cgtcctgggg gcctacgccg tagacaacac gtgtgtagtc aggagccggg     2340

acgtcagcac tacaggcagc accagcgaag gggccgtgac agccgttgcc atctgctgcc     2400

ggagccggca cctggcgcag gcctcccagg agctccagtg acagccccat cccaggatgg     2460

gtgtctgggg agggtcaagg gctggggctg agctttaaaa tggttccgac ttgtccctct     2520

ctcagccctc catggcctgg cacgagggga tggggatgct tccgcctttc cggggctgct     2580

ggcctggccc ttgagtgggg cagcctcctt gcctggaact cactcactct gggtgcctcc     2640

tccccaggtg gaggtgccag gaagctccct ccctcactgt ggggcatttc accattcaaa     2700

caggtcgagc tgtgctcggg tgctgccagc tgctcccaat gtgccgatgt ccgtgggcag     2760

aatgactttt attgagctct tgttccgtgc caggcattca atcctcaggt ctccaccaag     2820

gaggcaggat tcttcccatg gataggggag ggggcggtag gggctgcagg gacaaacatc     2880

gttggggggt gagtgtgaaa ggtgctgatg gccctcatct ccagctaact gtggagaagc     2940

ccctgggggc tccctgatta atggaggctt agctttctgg atggcatcta gccagaggct     3000

ggagacaggt gcgcccctgg tggtcacagg ctgtgccttg gtttcctgag ccacctttac     3060

tctgctctat gccaggctgt gctagcaaca cccaaaggtg gcctgcgggg agccatcacc     3120

taggactgac tcggcagtgt gcagtggtgc atgcactgtc tcagccaacc cgctccacta     3180

cccggcaggg tacacattcg cacccctact tcacagagga agaaacctgg aaccagaggg     3240

ggcgtgcctg ccaagctcac acagcaggaa ctgagccaga aacgcagatt gggctggctc     3300

tgaagccaag cctcttctta cttcacccgg ctgggctcct catttttacg ggtaacagtg     3360

aggctgggaa ggggaacaca gaccaggaag ctcggtgagt gatggcagaa cgatgcctgc     3420

aggcatggaa ctttttccgt tatcacccag gcctgattca ctggcctggc ggagatgctt     3480

ctaaggcatg gtcgggggag agggccaaca actgtccctc cttgagcacc agccccaccc     3540

aagcaagcag acatttatct tttgggtctg tcctctctgt tgccttttta cagccaactt     3600

ttctagacct gttttgcttt tgtaacttga agatatttat tctgggtttt gtagcatttt     3660

tattaatatg gtgacttttt aaaataaaaa caaacaaacg ttgtcctaac aaaaaaaaaa     3720

aaaaaaaaaa a                                                          3731


<210>  3
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador directo Luc2

<400>  4
aaacgcttcc acctaccagg                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador inverso Luc2

<400>  5
ccttagcctc gaagaagggc                                                   20


