                         SEQUENCE LISTING

<110>  Boehringer Ingelheim Vetmedica GmbH
 
<120>  MODIFIED S1 SUBUNIT OF THE CORONAVIRS SPIKE PROTEIN

<130>  01-3363 PCT and US

<160>  84    

<170>  PatentIn version 3.5

<210>  1
<211>  1162
<212>  PRT
<213>  Avian infectious bronchitis virus

<400>  1

Met Leu Val Thr Pro Leu Leu Leu Val Thr Leu Leu Cys Ala Leu Cys 
1               5                   10                  15      


Ser Ala Ala Leu Tyr Asp Ser Ser Ser Tyr Val Tyr Tyr Tyr Gln Ser 
            20                  25                  30          


Ala Phe Arg Pro Pro Asp Gly Trp His Leu His Gly Gly Ala Tyr Ala 
        35                  40                  45              


Val Val Asn Ile Ser Ser Glu Ser Asn Asn Ala Gly Ser Ser Ser Gly 
    50                  55                  60                  


Cys Thr Val Gly Ile Ile His Gly Gly Arg Val Val Asn Ala Ser Ser 
65                  70                  75                  80  


Ile Ala Met Thr Ala Pro Ser Ser Gly Met Ala Trp Ser Ser Ser Gln 
                85                  90                  95      


Phe Cys Thr Ala Tyr Cys Asn Phe Ser Asp Thr Thr Val Phe Val Thr 
            100                 105                 110         


His Cys Tyr Lys His Gly Gly Cys Pro Ile Thr Gly Met Leu Gln Gln 
        115                 120                 125             


His Ser Ile Arg Val Ser Ala Met Lys Asn Gly Gln Leu Phe Tyr Asn 
    130                 135                 140                 


Leu Thr Val Ser Val Ala Lys Tyr Pro Thr Phe Lys Ser Phe Gln Cys 
145                 150                 155                 160 


Val Asn Asn Leu Thr Ser Val Tyr Leu Asn Gly Asp Leu Val Tyr Thr 
                165                 170                 175     


Ser Asn Glu Thr Thr Asp Val Thr Ser Ala Gly Val Tyr Phe Lys Ala 
            180                 185                 190         


Gly Gly Pro Ile Thr Tyr Lys Val Met Arg Glu Val Arg Ala Leu Ala 
        195                 200                 205             


Tyr Phe Val Asn Gly Thr Ala Gln Asp Val Ile Leu Cys Asp Gly Ser 
    210                 215                 220                 


Pro Arg Gly Leu Leu Ala Cys Gln Tyr Asn Thr Gly Asn Phe Ser Asp 
225                 230                 235                 240 


Gly Phe Tyr Pro Phe Thr Asn Ser Ser Leu Val Lys Gln Lys Phe Ile 
                245                 250                 255     


Val Tyr Arg Glu Asn Ser Val Asn Thr Thr Phe Thr Leu His Asn Phe 
            260                 265                 270         


Thr Phe His Asn Glu Thr Gly Ala Asn Pro Asn Pro Ser Gly Val Gln 
        275                 280                 285             


Asn Ile Gln Thr Tyr Gln Thr Gln Thr Ala Gln Ser Gly Tyr Tyr Asn 
    290                 295                 300                 


Phe Asn Phe Ser Phe Leu Ser Ser Phe Val Tyr Lys Glu Ser Asn Phe 
305                 310                 315                 320 


Met Tyr Gly Ser Tyr His Pro Ser Cys Asn Phe Arg Leu Glu Thr Ile 
                325                 330                 335     


Asn Asn Gly Leu Trp Phe Asn Ser Leu Ser Val Ser Ile Ala Tyr Gly 
            340                 345                 350         


Pro Leu Gln Gly Gly Cys Lys Gln Ser Val Phe Ser Gly Arg Ala Thr 
        355                 360                 365             


Cys Cys Tyr Ala Tyr Ser Tyr Gly Gly Pro Leu Leu Cys Lys Gly Val 
    370                 375                 380                 


Tyr Ser Gly Glu Leu Asp His Asn Phe Glu Cys Gly Leu Leu Val Tyr 
385                 390                 395                 400 


Val Thr Lys Ser Gly Gly Ser Arg Ile Gln Thr Ala Thr Glu Pro Pro 
                405                 410                 415     


Val Ile Thr Gln His Asn Tyr Asn Asn Ile Thr Leu Asn Thr Cys Val 
            420                 425                 430         


Asp Tyr Asn Ile Tyr Gly Arg Thr Gly Gln Gly Phe Ile Thr Asn Val 
        435                 440                 445             


Thr Asp Ser Ala Val Ser Tyr Asn Tyr Leu Ala Asp Ala Gly Leu Ala 
    450                 455                 460                 


Ile Leu Asp Thr Ser Gly Ser Ile Asp Ile Phe Val Val Gln Ser Glu 
465                 470                 475                 480 


Tyr Gly Leu Asn Tyr Tyr Lys Val Asn Pro Cys Glu Asp Val Asn Gln 
                485                 490                 495     


Gln Phe Val Val Ser Gly Gly Lys Leu Val Gly Ile Leu Thr Ser Arg 
            500                 505                 510         


Asn Glu Thr Gly Ser Gln Leu Leu Glu Asn Gln Phe Tyr Ile Lys Ile 
        515                 520                 525             


Thr Asn Gly Thr Arg Arg Phe Arg Arg Ser Ile Thr Glu Ser Val Glu 
    530                 535                 540                 


Asn Cys Pro Tyr Val Ser Tyr Gly Lys Phe Cys Ile Lys Pro Asp Gly 
545                 550                 555                 560 


Ser Ile Ala Thr Ile Val Pro Lys Gln Leu Glu Gln Phe Val Ala Pro 
                565                 570                 575     


Leu Leu Asn Val Thr Glu Asn Val Leu Ile Pro Asn Ser Phe Asn Leu 
            580                 585                 590         


Thr Val Thr Asp Glu Tyr Ile Gln Thr Arg Met Asp Lys Val Gln Ile 
        595                 600                 605             


Asn Cys Leu Gln Tyr Ile Cys Gly Asn Ser Leu Glu Cys Arg Asn Leu 
    610                 615                 620                 


Phe Gln Gln Tyr Gly Pro Val Cys Asp Asn Ile Leu Ser Val Val Asn 
625                 630                 635                 640 


Ser Val Gly Gln Lys Glu Asp Met Glu Leu Leu Asn Phe Tyr Ser Ser 
                645                 650                 655     


Thr Lys Pro Ala Gly Phe Asn Thr Pro Val Leu Ser Asn Val Ser Thr 
            660                 665                 670         


Gly Glu Phe Asn Ile Thr Leu Phe Leu Thr Thr Pro Ser Ser Pro Arg 
        675                 680                 685             


Arg Arg Ser Phe Ile Glu Asp Leu Leu Phe Thr Ser Val Glu Ser Val 
    690                 695                 700                 


Gly Leu Pro Thr Asp Asp Ala Tyr Lys Asn Cys Thr Ala Gly Pro Leu 
705                 710                 715                 720 


Gly Phe Leu Lys Asp Leu Ala Cys Ala Arg Glu Tyr Asn Gly Leu Leu 
                725                 730                 735     


Val Leu Pro Pro Ile Ile Thr Ala Glu Met Gln Thr Leu Tyr Thr Ser 
            740                 745                 750         


Ser Leu Val Ala Ser Met Ala Phe Gly Gly Ile Thr Ala Ala Gly Ala 
        755                 760                 765             


Ile Pro Phe Ala Thr Gln Leu Gln Ala Arg Ile Asn His Leu Gly Ile 
    770                 775                 780                 


Thr Gln Ser Leu Leu Leu Lys Asn Gln Glu Lys Ile Ala Ala Ser Phe 
785                 790                 795                 800 


Asn Lys Ala Ile Gly His Met Gln Glu Gly Phe Arg Ser Thr Ser Leu 
                805                 810                 815     


Ala Leu Gln Gln Ile Gln Asp Val Val Asn Lys Gln Ser Ala Ile Leu 
            820                 825                 830         


Thr Glu Thr Met Ala Ser Leu Asn Lys Asn Phe Gly Ala Ile Ser Ser 
        835                 840                 845             


Val Ile Gln Glu Ile Tyr Gln Gln Leu Asp Ala Ile Gln Ala Asn Ala 
    850                 855                 860                 


Gln Val Asp Arg Leu Ile Thr Gly Arg Leu Ser Ser Leu Ser Val Leu 
865                 870                 875                 880 


Ala Ser Ala Lys Gln Ala Glu Tyr Ile Arg Val Ser Gln Gln Arg Glu 
                885                 890                 895     


Leu Ala Thr Gln Lys Ile Asn Glu Cys Val Lys Ser Gln Ser Ile Arg 
            900                 905                 910         


Tyr Ser Phe Cys Gly Asn Gly Arg His Val Leu Thr Ile Pro Gln Asn 
        915                 920                 925             


Ala Pro Asn Gly Ile Val Phe Ile His Phe Ser Tyr Thr Pro Asp Ser 
    930                 935                 940                 


Phe Val Asn Val Thr Ala Ile Val Gly Phe Cys Val Lys Pro Ala Asn 
945                 950                 955                 960 


Ala Ser Gln Tyr Ala Ile Val Pro Ala Asn Gly Arg Gly Ile Phe Ile 
                965                 970                 975     


Gln Val Asn Gly Ser Tyr Tyr Ile Thr Ala Arg Asp Met Tyr Met Pro 
            980                 985                 990         


Arg Ala Ile Thr Ala Gly Asp Ile  Val Thr Leu Thr Ser  Cys Gln Ala 
        995                 1000                 1005             


Asn Tyr  Val Ser Val Asn Lys  Thr Val Ile Thr Thr  Phe Val Asp 
    1010                 1015                 1020             


Asn Asp  Asp Phe Asp Phe Asn  Asp Glu Leu Ser Lys  Trp Trp Asn 
    1025                 1030                 1035             


Asp Thr  Lys His Glu Leu Pro  Asp Phe Asp Lys Phe  Asn Tyr Thr 
    1040                 1045                 1050             


Val Pro  Ile Leu Asp Ile Asp  Ser Glu Ile Asp Arg  Ile Gln Gly 
    1055                 1060                 1065             


Val Ile  Gln Gly Leu Asn Asp  Ser Leu Ile Asp Leu  Glu Lys Leu 
    1070                 1075                 1080             


Ser Ile  Leu Lys Thr Tyr Ile  Lys Trp Pro Trp Tyr  Val Trp Leu 
    1085                 1090                 1095             


Ala Ile  Ala Phe Ala Thr Ile  Ile Phe Ile Leu Ile  Leu Gly Trp 
    1100                 1105                 1110             


Val Phe  Phe Met Thr Gly Cys  Cys Gly Cys Cys Cys  Gly Cys Phe 
    1115                 1120                 1125             


Gly Ile  Met Pro Leu Met Ser  Lys Cys Gly Lys Lys  Ser Ser Tyr 
    1130                 1135                 1140             


Tyr Thr  Thr Phe Asp Asn Asp  Val Val Thr Glu Gln  Tyr Arg Pro 
    1145                 1150                 1155             


Lys Lys  Ser Val 
    1160         


<210>  2
<211>  1162
<212>  PRT
<213>  Avian infectious bronchitis virus

<400>  2

Met Leu Val Thr Pro Leu Leu Leu Val Thr Leu Leu Cys Ala Leu Cys 
1               5                   10                  15      


Ser Ala Ala Leu Tyr Asp Ser Ser Ser Tyr Val Tyr Tyr Tyr Gln Ser 
            20                  25                  30          


Ala Phe Arg Pro Pro Asp Gly Trp His Leu His Gly Gly Ala Tyr Ala 
        35                  40                  45              


Val Val Asn Ile Ser Ser Glu Ser Asn Asn Ala Gly Ser Ser Ser Gly 
    50                  55                  60                  


Cys Thr Val Gly Ile Ile His Gly Gly Arg Val Val Asn Ala Ser Ser 
65                  70                  75                  80  


Ile Ala Met Thr Ala Pro Ser Ser Gly Met Ala Trp Ser Ser Ser Gln 
                85                  90                  95      


Phe Cys Thr Ala Tyr Cys Asn Phe Ser Asp Thr Thr Val Phe Val Thr 
            100                 105                 110         


His Cys Tyr Lys His Gly Gly Cys Pro Ile Thr Gly Met Leu Gln Gln 
        115                 120                 125             


His Ser Ile Arg Val Ser Ala Met Lys Asn Gly Gln Leu Phe Tyr Asn 
    130                 135                 140                 


Leu Thr Val Ser Val Ala Lys Tyr Pro Thr Phe Lys Ser Phe Gln Cys 
145                 150                 155                 160 


Val Asn Asn Leu Thr Ser Val Tyr Leu Asn Gly Asp Leu Val Tyr Thr 
                165                 170                 175     


Ser Asn Glu Thr Thr Asp Val Thr Ser Ala Gly Val Tyr Phe Lys Ala 
            180                 185                 190         


Gly Gly Pro Ile Thr Tyr Lys Val Met Arg Glu Val Arg Ala Leu Ala 
        195                 200                 205             


Tyr Phe Val Asn Gly Thr Ala Gln Asp Val Ile Leu Cys Asp Gly Ser 
    210                 215                 220                 


Pro Arg Gly Leu Leu Ala Cys Gln Tyr Asn Thr Gly Asn Phe Ser Asp 
225                 230                 235                 240 


Gly Phe Tyr Pro Phe Thr Asn Ser Ser Leu Val Lys Gln Lys Phe Ile 
                245                 250                 255     


Val Tyr Arg Glu Asn Ser Val Asn Thr Thr Cys Thr Leu His Asn Phe 
            260                 265                 270         


Thr Phe His Asn Glu Thr Gly Ala Asn Pro Asn Pro Ser Gly Val Gln 
        275                 280                 285             


Asn Ile Gln Thr Tyr Gln Thr Gln Thr Ala Gln Ser Gly Tyr Tyr Asn 
    290                 295                 300                 


Phe Asn Phe Ser Phe Leu Ser Ser Phe Val Tyr Lys Glu Ser Asn Phe 
305                 310                 315                 320 


Met Tyr Gly Ser Tyr His Pro Ser Cys Asn Phe Arg Leu Glu Thr Ile 
                325                 330                 335     


Asn Asn Gly Leu Trp Phe Asn Ser Leu Ser Val Ser Ile Ala Tyr Gly 
            340                 345                 350         


Pro Leu Gln Gly Gly Cys Lys Gln Ser Val Phe Ser Gly Arg Ala Thr 
        355                 360                 365             


Cys Cys Tyr Ala Tyr Ser Tyr Gly Gly Pro Leu Leu Cys Lys Gly Val 
    370                 375                 380                 


Tyr Ser Gly Glu Leu Asp His Asn Phe Glu Cys Gly Leu Leu Val Tyr 
385                 390                 395                 400 


Val Thr Lys Ser Gly Gly Ser Arg Ile Gln Thr Ala Thr Glu Pro Pro 
                405                 410                 415     


Val Ile Thr Gln His Asn Tyr Asn Asn Ile Thr Leu Asn Thr Cys Val 
            420                 425                 430         


Asp Tyr Asn Ile Tyr Gly Arg Thr Gly Gln Gly Phe Ile Thr Asn Val 
        435                 440                 445             


Thr Asp Ser Ala Val Ser Tyr Asn Tyr Leu Ala Asp Ala Gly Leu Ala 
    450                 455                 460                 


Ile Leu Asp Thr Ser Gly Ser Ile Asp Ile Phe Val Val Gln Ser Glu 
465                 470                 475                 480 


Tyr Gly Leu Asn Tyr Tyr Lys Val Asn Pro Cys Glu Asp Val Asn Gln 
                485                 490                 495     


Gln Phe Val Val Ser Gly Gly Lys Leu Val Gly Ile Leu Thr Ser Arg 
            500                 505                 510         


Asn Glu Thr Gly Ser Gln Leu Leu Glu Asn Gln Phe Tyr Ile Lys Ile 
        515                 520                 525             


Thr Asn Gly Thr Arg Arg Phe Arg Arg Ser Ile Thr Glu Ser Val Glu 
    530                 535                 540                 


Asn Cys Pro Tyr Val Ser Tyr Gly Lys Phe Cys Ile Lys Pro Asp Gly 
545                 550                 555                 560 


Ser Ile Ala Thr Ile Val Pro Lys Gln Leu Glu Gln Phe Val Ala Pro 
                565                 570                 575     


Leu Leu Asn Val Thr Glu Asn Val Leu Ile Pro Asn Ser Phe Asn Leu 
            580                 585                 590         


Thr Val Thr Asp Glu Tyr Ile Gln Thr Arg Met Asp Lys Val Gln Ile 
        595                 600                 605             


Asn Cys Leu Gln Tyr Ile Cys Gly Asn Ser Leu Glu Cys Arg Asn Leu 
    610                 615                 620                 


Phe Gln Gln Tyr Gly Pro Val Cys Asp Asn Ile Leu Ser Val Val Asn 
625                 630                 635                 640 


Ser Val Gly Gln Lys Glu Asp Met Glu Leu Leu Asn Phe Tyr Ser Ser 
                645                 650                 655     


Thr Lys Pro Ala Gly Phe Asn Thr Pro Val Leu Ser Asn Val Ser Thr 
            660                 665                 670         


Gly Glu Phe Asn Ile Thr Leu Phe Leu Thr Thr Pro Ser Ser Pro Arg 
        675                 680                 685             


Arg Arg Ser Phe Ile Glu Asp Leu Leu Phe Thr Ser Val Glu Ser Val 
    690                 695                 700                 


Gly Leu Pro Thr Asp Asp Ala Tyr Lys Asn Cys Thr Ala Gly Pro Leu 
705                 710                 715                 720 


Gly Phe Leu Lys Asp Leu Ala Cys Ala Arg Glu Tyr Asn Gly Leu Leu 
                725                 730                 735     


Val Leu Pro Pro Ile Ile Thr Ala Glu Met Gln Thr Leu Tyr Thr Ser 
            740                 745                 750         


Ser Leu Val Ala Ser Met Ala Phe Gly Gly Ile Thr Ala Ala Gly Ala 
        755                 760                 765             


Ile Pro Phe Ala Thr Gln Leu Gln Ala Arg Ile Asn His Leu Gly Ile 
    770                 775                 780                 


Thr Gln Ser Leu Leu Leu Lys Asn Gln Glu Lys Ile Ala Ala Ser Phe 
785                 790                 795                 800 


Asn Lys Ala Ile Gly His Met Gln Glu Gly Phe Arg Ser Thr Ser Leu 
                805                 810                 815     


Ala Leu Gln Gln Ile Gln Asp Val Val Asn Lys Gln Ser Ala Ile Leu 
            820                 825                 830         


Thr Glu Thr Met Ala Ser Leu Asn Lys Asn Phe Gly Ala Ile Ser Ser 
        835                 840                 845             


Val Ile Gln Glu Ile Tyr Gln Gln Leu Asp Ala Ile Gln Ala Asn Ala 
    850                 855                 860                 


Gln Val Asp Arg Leu Ile Thr Gly Arg Leu Ser Ser Leu Ser Val Leu 
865                 870                 875                 880 


Ala Ser Ala Lys Gln Ala Glu Tyr Ile Arg Val Ser Gln Gln Arg Glu 
                885                 890                 895     


Leu Ala Thr Gln Lys Ile Asn Glu Cys Val Lys Ser Gln Ser Ile Arg 
            900                 905                 910         


Tyr Ser Phe Cys Gly Asn Gly Arg His Val Leu Thr Ile Pro Gln Asn 
        915                 920                 925             


Ala Pro Asn Gly Ile Val Phe Ile His Phe Ser Tyr Thr Pro Asp Ser 
    930                 935                 940                 


Phe Val Asn Val Thr Ala Ile Val Gly Phe Cys Val Lys Pro Ala Asn 
945                 950                 955                 960 


Ala Ser Gln Tyr Ala Ile Val Pro Ala Asn Gly Arg Gly Ile Phe Ile 
                965                 970                 975     


Gln Val Asn Gly Ser Tyr Tyr Ile Thr Ala Arg Asp Met Tyr Met Pro 
            980                 985                 990         


Arg Ala Ile Thr Ala Gly Asp Ile  Val Thr Leu Thr Ser  Cys Gln Ala 
        995                 1000                 1005             


Asn Tyr  Val Ser Val Asn Lys  Thr Val Ile Thr Thr  Phe Val Asp 
    1010                 1015                 1020             


Asn Asp  Asp Phe Asp Phe Asn  Asp Glu Leu Ser Lys  Trp Trp Asn 
    1025                 1030                 1035             


Asp Thr  Lys His Glu Leu Pro  Asp Phe Asp Lys Phe  Asn Tyr Thr 
    1040                 1045                 1050             


Val Pro  Ile Leu Asp Ile Asp  Ser Glu Ile Asp Arg  Ile Gln Gly 
    1055                 1060                 1065             


Val Ile  Gln Gly Leu Asn Asp  Ser Leu Ile Asp Leu  Glu Lys Leu 
    1070                 1075                 1080             


Ser Ile  Leu Lys Thr Tyr Ile  Lys Trp Pro Trp Tyr  Val Trp Leu 
    1085                 1090                 1095             


Ala Ile  Ala Phe Ala Thr Ile  Ile Phe Ile Leu Ile  Leu Gly Trp 
    1100                 1105                 1110             


Val Phe  Phe Met Thr Gly Cys  Cys Gly Cys Cys Cys  Gly Cys Phe 
    1115                 1120                 1125             


Gly Ile  Met Pro Leu Met Ser  Lys Cys Gly Lys Lys  Ser Ser Tyr 
    1130                 1135                 1140             


Tyr Thr  Thr Phe Asp Asn Asp  Val Val Thr Glu Gln  Tyr Arg Pro 
    1145                 1150                 1155             


Lys Lys  Ser Val 
    1160         


<210>  3
<211>  1155
<212>  PRT
<213>  Avian infectious bronchitis virus

<400>  3

Met Leu Asp Lys Pro Leu Leu Leu Val Thr Leu Trp Tyr Ala Leu Cys 
1               5                   10                  15      


Ser Ala Leu Leu Tyr Asp Asn Asn Thr Tyr Val Tyr Tyr Tyr Gln Ser 
            20                  25                  30          


Ala Phe Arg Pro Gly Pro Gly Trp His Leu Tyr Gly Gly Ala Tyr Ala 
        35                  40                  45              


Val Asp Arg Val Phe Asn Glu Thr Asn Asn Ala Gly Ser Ala Ser Asp 
    50                  55                  60                  


Cys Thr Ala Gly Thr Phe Tyr Glu Ser His Asn Ile Ser Ala Ser Ser 
65                  70                  75                  80  


Val Ala Met Thr Val Pro His Asn Gly Met Ser Trp Ser Ala Ser Gln 
                85                  90                  95      


Phe Cys Thr Ala His Cys Asn Phe Ser Asp Phe Thr Val Phe Val Thr 
            100                 105                 110         


His Cys Phe Lys Asn Gln Leu Gly Ser Cys Pro Leu Thr Gly Met Ile 
        115                 120                 125             


Pro Gln Asn His Ile Arg Ile Ser Ala Met Arg Asp Gly Val Leu Phe 
    130                 135                 140                 


Tyr Asn Leu Thr Val Ser Val Ser Lys Tyr Pro Arg Phe Lys Ser Leu 
145                 150                 155                 160 


Gln Cys Val Ser Asn Ser Thr Ser Val Tyr Val Asn Gly Asp Leu Val 
                165                 170                 175     


Phe Thr Ser Asn Glu Thr Ser Tyr Val Thr Gly Ala Gly Val Tyr Phe 
            180                 185                 190         


Lys Ser Gly Gly Pro Val Thr Tyr Lys Val Met Lys Glu Val Lys Ala 
        195                 200                 205             


Leu Ala Tyr Phe Ile Asn Gly Thr Ala Gln Glu Val Ile Leu Cys Asp 
    210                 215                 220                 


Asn Ser Pro Arg Gly Leu Leu Ala Cys Gln Tyr Asn Thr Gly Asn Phe 
225                 230                 235                 240 


Ser Asp Gly Phe Tyr Pro Phe Thr Asn His Ser Leu Val Lys Asp Arg 
                245                 250                 255     


Phe Ile Val Tyr Arg Glu Ser Ser Thr Asn Thr Thr Cys Lys Leu Thr 
            260                 265                 270         


Asn Phe Ser Phe Thr Asn Val Ser Asn Ala Ser Pro Asn Ser Gly Gly 
        275                 280                 285             


Val Asp Thr Phe Gln Leu Tyr Gln Thr Ser Thr Ala Gln Asp Gly Tyr 
    290                 295                 300                 


Tyr Asn Phe Asn Leu Ser Phe Leu Ser Ser Phe Val Tyr Lys Pro Ser 
305                 310                 315                 320 


Asp Phe Met Tyr Gly Ser Tyr His Pro His Cys Lys Phe Arg Pro Glu 
                325                 330                 335     


Asn Ile Asn Asn Gly Leu Trp Phe Asn Ser Leu Ser Val Ser Leu Thr 
            340                 345                 350         


Tyr Gly Pro Ile Gln Gly Gly Cys Lys Gln Ser Val Phe Ser Asn Arg 
        355                 360                 365             


Ala Thr Cys Cys Tyr Ala Tyr Ser Tyr Gln Gly Pro Ser Arg Cys Lys 
    370                 375                 380                 


Gly Val Tyr Arg Gly Glu Leu Thr Gln Tyr Phe Glu Cys Gly Leu Leu 
385                 390                 395                 400 


Val Tyr Val Thr Lys Ser Asp Gly Ser Arg Ile Gln Thr Arg Ser Glu 
                405                 410                 415     


Pro Leu Val Leu Thr Gln Tyr Asn Tyr Asn Asn Ile Thr Leu Asn Lys 
            420                 425                 430         


Cys Val Glu Tyr Asn Ile Tyr Gly Arg Val Gly Gln Gly Phe Ile Thr 
        435                 440                 445             


Asn Val Thr Glu Ala Thr Ala Asn Tyr Ser Tyr Leu Ala Asp Gly Gly 
    450                 455                 460                 


Leu Ala Ile Leu Asp Thr Ser Gly Ala Ile Asp Ile Phe Val Val Gln 
465                 470                 475                 480 


Gly Ala Tyr Gly Leu Asn Tyr Tyr Lys Val Asn Pro Cys Glu Asp Val 
                485                 490                 495     


Asn Gln Gln Phe Val Val Ser Gly Gly Asn Leu Val Gly Ile Leu Thr 
            500                 505                 510         


Ser His Asn Glu Thr Gly Ser Glu Ser Ile Glu Asn Gln Phe Tyr Ile 
        515                 520                 525             


Lys Leu Thr Asn Gly Thr Arg Arg Ser Arg Arg Ser Val Thr Gly Asn 
    530                 535                 540                 


Val Thr Asn Cys Pro Tyr Val Ser Tyr Gly Lys Phe Cys Ile Lys Pro 
545                 550                 555                 560 


Asp Gly Ser Leu Ser Ile Ile Val Pro Gln Glu Leu Glu Gln Phe Val 
                565                 570                 575     


Ala Pro Leu Phe Asn Val Thr Glu His Val Leu Ile Pro Asp Ser Phe 
            580                 585                 590         


Asn Leu Thr Val Thr Asp Glu Tyr Ile Gln Thr Arg Met Asp Lys Val 
        595                 600                 605             


Gln Ile Ile Cys Leu Gln Tyr Val Cys Gly Asn Ser Ile Glu Cys Arg 
    610                 615                 620                 


Lys Leu Phe Gln Gln Tyr Gly Pro Val Cys Asp Asn Ile Leu Ser Val 
625                 630                 635                 640 


Val Asn Gly Val Gly Gln Arg Glu Asp Met Glu Leu Leu Ser Phe Tyr 
                645                 650                 655     


Ser Ser Thr Lys Pro Ser Gly Tyr Asn Thr Pro Ile Phe Asn Asn Val 
            660                 665                 670         


Ser Thr Gly Asp Phe Asn Ile Ser Leu Leu Leu Thr Pro Pro Asn Ser 
        675                 680                 685             


Pro Thr Gly Arg Ser Phe Ile Glu Asp Leu Leu Phe Thr Ser Val Glu 
    690                 695                 700                 


Ser Val Gly Leu Pro Thr Asp Glu Glu Tyr Lys Lys Cys Thr Ala Gly 
705                 710                 715                 720 


Pro Leu Gly Phe Val Lys Asp Leu Val Cys Ala Arg Glu Tyr Asn Gly 
                725                 730                 735     


Leu Leu Val Leu Pro Pro Ile Ile Thr Ala Glu Met Gln Thr Met Tyr 
            740                 745                 750         


Thr Ser Ser Leu Val Ala Ser Met Ala Leu Gly Gly Ile Thr Ala Ala 
        755                 760                 765             


Gly Ala Ile Pro Phe Ala Thr Gln Leu Gln Ala Arg Ile Asn His Leu 
    770                 775                 780                 


Gly Ile Thr Asn Ser Leu Leu Leu Lys Asn Gln Glu Lys Ile Ala Ala 
785                 790                 795                 800 


Ser Phe Asn Lys Ala Ile Gly His Met Gln Glu Gly Phe Lys Ser Thr 
                805                 810                 815     


Ser Leu Ala Leu Gln Gln Ile Gln Asp Val Val Asn Lys Gln Ser Ser 
            820                 825                 830         


Ile Leu Thr Glu Thr Met Gln Ser Leu Asn Lys Asn Phe Gly Ala Ile 
        835                 840                 845             


Ser Ser Val Ile Gln Asp Ile Tyr Gln Gln Leu Asp Ala Ile Gln Ala 
    850                 855                 860                 


Asp Ala Gln Val Asp Arg Leu Ile Thr Gly Arg Leu Ser Ser Leu Ser 
865                 870                 875                 880 


Val Leu Ala Ser Ala Lys Gln Ala Glu Tyr His Arg Val Ser Gln Gln 
                885                 890                 895     


Arg Glu Leu Ala Thr Gln Lys Ile Asn Glu Cys Val Lys Ser Gln Ser 
            900                 905                 910         


Asn Arg Tyr Ser Phe Cys Gly Asn Gly Arg His Val Leu Thr Ile Pro 
        915                 920                 925             


Gln Asn Ala Pro Asn Gly Ile Val Phe Ile His Phe Thr Tyr Thr Pro 
    930                 935                 940                 


Glu Ser Phe Val Asn Val Thr Ala Ile Val Gly Phe Cys Val Asn Pro 
945                 950                 955                 960 


Ala Asn Ala Ser His Tyr Ala Ile Val Pro Val Asn Gly Arg Gly Val 
                965                 970                 975     


Phe Ile Glu Val Asn Gly Ser Tyr Tyr Ile Thr Ala Arg Asp Met Tyr 
            980                 985                 990         


Met Pro Arg Asp Ile Thr Ala Gly  Asp Ile Val Thr Leu  Thr Ser Cys 
        995                 1000                 1005             


Gln Ala  Asn Tyr Val Asn Val  Asn Lys Thr Val Ile  Asn Thr Phe 
    1010                 1015                 1020             


Val Glu  Asp Asp Asp Phe Asp  Phe Tyr Asp Glu Leu  Ser Lys Trp 
    1025                 1030                 1035             


Trp Asn  Asp Thr Lys His Glu  Leu Pro Asp Phe Asp  Glu Phe Asn 
    1040                 1045                 1050             


Tyr Thr  Val Pro Val Leu Asn  Ile Ser Asn Glu Ile  Asp Arg Ile 
    1055                 1060                 1065             


Gln Gln  Val Ile Gln Gly Leu  Asn Asp Ser Leu Ile  Asp Leu Glu 
    1070                 1075                 1080             


Thr Leu  Ser Ile Leu Lys Thr  Tyr Ile Lys Trp Pro  Trp Tyr Val 
    1085                 1090                 1095             


Trp Leu  Ala Ile Ala Phe Leu  Thr Ile Ile Phe Ile  Leu Val Leu 
    1100                 1105                 1110             


Cys Trp  Ile Phe Phe Met Thr  Gly Cys Cys Gly Cys  Cys Cys Gly 
    1115                 1120                 1125             


Cys Phe  Gly Ile Ile Pro Leu  Met Ser Lys Cys Gly  Lys Lys Ser 
    1130                 1135                 1140             


Ser Tyr  Tyr Thr Thr Phe Asp  Asn Asp Val Val Thr  
    1145                 1150                 1155 


<210>  4
<211>  1156
<212>  PRT
<213>  Avian infectious bronchitis virus

<400>  4

Met Leu Val Lys Ser Leu Phe Leu Val Thr Ile Leu Cys Ala Leu Cys 
1               5                   10                  15      


Ser Ala Asn Leu Phe Asp Ser Asp Asn Asn Tyr Val Tyr Tyr Tyr Gln 
            20                  25                  30          


Ser Ala Phe Arg Pro Pro Asn Gly Trp His Leu Gln Gly Gly Ala Tyr 
        35                  40                  45              


Ala Val Val Ser Ser Thr Asn Tyr Thr Asn Asn Ala Gly Ser Ala His 
    50                  55                  60                  


Gly Cys Thr Val Gly Val Ile Lys Asp Val Tyr Asn Gln Ser Val Ala 
65                  70                  75                  80  


Ser Ile Ala Met Thr Ala Pro Leu Gln Gly Met Ala Trp Ser Lys Ser 
                85                  90                  95      


Gln Phe Cys Ser Ala His Cys Asn Phe Ser Glu Ile Thr Val Phe Val 
            100                 105                 110         


Thr His Cys Tyr Ser Ser Gly Ser Gly Ser Cys Pro Ile Thr Gly Met 
        115                 120                 125             


Ile Pro Arg Asp His Ile Arg Ile Ser Ala Met Lys Asn Gly Ser Leu 
    130                 135                 140                 


Phe Tyr Asn Leu Thr Val Ser Val Ser Lys Tyr Pro Asn Phe Lys Ser 
145                 150                 155                 160 


Phe Gln Cys Val Asn Asn Phe Thr Ser Val Tyr Leu Asn Gly Asp Leu 
                165                 170                 175     


Val Phe Thr Ser Asn Lys Thr Thr Asp Val Thr Ser Ala Gly Val Tyr 
            180                 185                 190         


Phe Lys Ala Gly Gly Pro Val Asn Tyr Ser Ile Met Lys Glu Phe Lys 
        195                 200                 205             


Val Leu Ala Tyr Phe Val Asn Gly Thr Ala Gln Asp Val Val Leu Cys 
    210                 215                 220                 


Asp Asn Ser Pro Lys Gly Leu Leu Ala Cys Gln Tyr Asn Thr Gly Asn 
225                 230                 235                 240 


Phe Ser Asp Gly Phe Tyr Pro Phe Thr Asn Ser Thr Leu Val Arg Glu 
                245                 250                 255     


Lys Phe Ile Val Tyr Arg Glu Ser Ser Val Asn Thr Thr Cys Ala Leu 
            260                 265                 270         


Thr Asn Phe Thr Phe Ser Asn Val Ser Asn Ala Gln Pro Asn Ser Gly 
        275                 280                 285             


Gly Val Asn Thr Phe His Leu Tyr Gln Thr Gln Thr Ala Gln Ser Gly 
    290                 295                 300                 


Tyr Tyr Asn Phe Asn Leu Ser Phe Leu Ser Gln Phe Val Tyr Lys Ala 
305                 310                 315                 320 


Ser Asp Phe Met Tyr Gly Ser Tyr His Pro Ser Cys Ser Phe Arg Pro 
                325                 330                 335     


Glu Thr Ile Asn Ser Gly Leu Trp Phe Asn Ser Leu Ser Val Ser Leu 
            340                 345                 350         


Thr Tyr Gly Pro Leu Gln Gly Gly Cys Lys Gln Ser Val Phe Ser Gly 
        355                 360                 365             


Lys Ala Thr Cys Cys Tyr Ala Tyr Ser Tyr Arg Gly Pro Met Ala Cys 
    370                 375                 380                 


Lys Gly Val Tyr Ser Gly Glu Leu Ser Thr Asn Phe Glu Cys Gly Leu 
385                 390                 395                 400 


Leu Val Tyr Val Thr Lys Ser Asp Gly Ser Arg Ile Gln Thr Arg Thr 
                405                 410                 415     


Glu Pro Leu Val Leu Thr Gln Tyr Asn Tyr Asn Asn Ile Thr Leu Asp 
            420                 425                 430         


Lys Cys Val Ala Tyr Asn Ile Tyr Gly Arg Val Gly Gln Gly Phe Ile 
        435                 440                 445             


Thr Asn Val Thr Asp Ser Ala Ala Asn Phe Ser Tyr Leu Ala Asp Gly 
    450                 455                 460                 


Gly Leu Ala Ile Leu Asp Thr Ser Gly Ala Ile Asp Val Phe Val Val 
465                 470                 475                 480 


Gln Gly Ile Tyr Gly Leu Asn Tyr Tyr Lys Val Asn Pro Cys Glu Asp 
                485                 490                 495     


Val Asn Gln Gln Phe Val Val Ser Gly Gly Asn Ile Val Gly Ile Leu 
            500                 505                 510         


Thr Ser Arg Asn Glu Thr Gly Ser Glu Gln Val Glu Asn Gln Phe Tyr 
        515                 520                 525             


Val Lys Leu Thr Asn Ser Ser His Arg Arg Lys Arg Ser Ile Gly Gln 
    530                 535                 540                 


Asn Val Thr Ser Cys Pro Tyr Val Ser Tyr Gly Arg Phe Cys Ile Glu 
545                 550                 555                 560 


Pro Asp Gly Ser Leu Lys Met Ile Val Pro Glu Glu Leu Lys Gln Phe 
                565                 570                 575     


Val Ala Pro Leu Leu Asn Ile Thr Glu Ser Val Leu Ile Pro Asn Ser 
            580                 585                 590         


Phe Asn Leu Thr Val Thr Asp Glu Tyr Ile Gln Thr Arg Met Asp Lys 
        595                 600                 605             


Val Gln Ile Asn Cys Leu Gln Tyr Val Cys Gly Asn Ser Leu Glu Cys 
    610                 615                 620                 


Arg Lys Leu Phe Gln Gln Tyr Gly Pro Val Cys Asp Asn Ile Leu Ser 
625                 630                 635                 640 


Val Val Asn Ser Val Ser Gln Lys Glu Asp Met Glu Leu Leu Ser Phe 
                645                 650                 655     


Tyr Ser Ser Thr Lys Pro Lys Gly Tyr Asp Thr Pro Val Leu Ser Asn 
            660                 665                 670         


Val Ser Thr Gly Glu Phe Asn Ile Ser Leu Leu Leu Lys Pro Pro Ser 
        675                 680                 685             


Ser Pro Ser Gly Arg Ser Phe Ile Glu Glu Leu Leu Phe Thr Ser Val 
    690                 695                 700                 


Glu Thr Val Gly Leu Pro Thr Asp Ala Glu Tyr Lys Lys Cys Thr Ala 
705                 710                 715                 720 


Gly Pro Leu Gly Thr Leu Lys Asp Leu Ile Cys Ala Arg Glu Tyr Asn 
                725                 730                 735     


Gly Leu Leu Val Leu Pro Pro Ile Ile Thr Ala Asp Met Gln Thr Met 
            740                 745                 750         


Tyr Thr Ala Ser Leu Val Gly Ala Met Ala Phe Gly Gly Ile Thr Ser 
        755                 760                 765             


Ala Ala Ala Ile Pro Phe Ala Thr Gln Ile Gln Ala Arg Ile Asn His 
    770                 775                 780                 


Leu Gly Ile Thr Gln Ser Leu Leu Met Lys Asn Gln Glu Lys Ile Ala 
785                 790                 795                 800 


Ala Ser Phe Asn Lys Ala Ile Gly His Met Gln Glu Gly Phe Arg Ser 
                805                 810                 815     


Thr Ser Leu Ala Leu Gln Gln Ile Gln Asp Val Val Asn Lys Gln Ser 
            820                 825                 830         


Ala Ile Leu Thr Glu Thr Met Asn Ser Leu Asn Lys Asn Phe Gly Ala 
        835                 840                 845             


Ile Thr Ser Val Ile Gln Asp Ile Tyr Ala Gln Leu Asp Ala Ile Gln 
    850                 855                 860                 


Ala Asp Ala Gln Val Asp Arg Leu Ile Thr Gly Arg Leu Ser Ser Leu 
865                 870                 875                 880 


Ser Val Leu Ala Ser Ala Lys Gln Ser Glu Tyr Ile Arg Val Ser Gln 
                885                 890                 895     


Gln Arg Glu Leu Ala Thr Gln Lys Ile Asn Glu Cys Val Lys Ser Gln 
            900                 905                 910         


Ser Asn Arg Tyr Gly Phe Cys Gly Ser Gly Arg His Val Leu Ser Ile 
        915                 920                 925             


Pro Gln Asn Ala Pro Asn Gly Ile Val Phe Ile His Phe Thr Tyr Thr 
    930                 935                 940                 


Pro Glu Ser Phe Val Asn Val Thr Ala Ile Val Gly Phe Cys Val Asn 
945                 950                 955                 960 


Pro Ala Asn Ala Ser Gln Tyr Ala Ile Val Pro Ala Asn Gly Arg Gly 
                965                 970                 975     


Ile Phe Ile Gln Val Asn Gly Thr Tyr Tyr Ile Thr Ala Arg Asp Met 
            980                 985                 990         


Tyr Met Pro Arg Asp Ile Thr Ala  Gly Asp Ile Val Thr  Leu Thr Ser 
        995                 1000                 1005             


Cys Gln  Ala Asn Tyr Val Asn  Val Asn Lys Thr Val  Ile Thr Thr 
    1010                 1015                 1020             


Phe Val  Glu Asp Asp Asp Phe  Asp Phe Asp Asp Glu  Leu Ser Lys 
    1025                 1030                 1035             


Trp Trp  Asn Asp Thr Lys His  Gln Leu Pro Asp Phe  Asp Asp Phe 
    1040                 1045                 1050             


Asn Tyr  Thr Val Pro Ile Leu  Asn Ile Ser Gly Glu  Ile Asp Tyr 
    1055                 1060                 1065             


Ile Gln  Gly Val Ile Gln Gly  Leu Asn Asp Ser Leu  Ile Asp Leu 
    1070                 1075                 1080             


Glu Glu  Leu Ser Ile Ile Lys  Thr Tyr Ile Lys Trp  Pro Trp Tyr 
    1085                 1090                 1095             


Val Trp  Leu Ala Ile Phe Phe  Ala Ile Ile Ile Phe  Ile Leu Ile 
    1100                 1105                 1110             


Leu Gly  Trp Val Phe Phe Met  Thr Gly Cys Cys Gly  Cys Cys Cys 
    1115                 1120                 1125             


Gly Cys  Phe Gly Ile Ile Pro  Leu Met Ser Lys Cys  Gly Lys Lys 
    1130                 1135                 1140             


Ser Ser  Tyr Tyr Thr Thr Phe  Asp Asn Asp Val Val  Thr 
    1145                 1150                 1155     


<210>  5
<211>  1156
<212>  PRT
<213>  Avian infectious bronchitis virus

<400>  5

Met Leu Gly Lys Ser Leu Phe Val Val Thr Leu Leu Phe Ala Leu Cys 
1               5                   10                  15      


Ser Ala Ala Leu Phe Asp Asn Asn Glu Thr Val Tyr Tyr Tyr Gln Ser 
            20                  25                  30          


Ala Phe Arg Pro Ala Asp Gly Trp His Leu His Gly Gly Ala Tyr Ala 
        35                  40                  45              


Val Val Asn Val Ser Leu Gln Thr Ser Asn Ala Gly Thr Val Ser Glu 
    50                  55                  60                  


Cys Ile Ala Gly Ala Ile Ser Trp Ser Lys Glu Phe Ser Ala Ser Ala 
65                  70                  75                  80  


Val Ala Met Thr Ala Pro Gln Leu Gly Met Thr Trp Ser Thr Arg Gln 
                85                  90                  95      


Phe Cys Thr Ala His Cys Asn Phe Ser Asp Phe Thr Val Phe Val Thr 
            100                 105                 110         


His Cys Phe Lys His Gly Thr Gly Leu Cys Pro Leu Thr Gly Phe Ile 
        115                 120                 125             


Pro Ser Gly Phe Ile Arg Val Ser Ala Met Arg Lys Gly Ser Asn Ser 
    130                 135                 140                 


Leu Phe Tyr Asn Leu Thr Val Ser Val Thr Lys Tyr Pro Arg Phe Lys 
145                 150                 155                 160 


Ser Leu Gln Cys Val Asn Asn Tyr Thr Ser Val Tyr Leu Asn Gly Asp 
                165                 170                 175     


Leu Val Phe Thr Ser Asn Glu Thr Lys Pro Val Ser Ala Ala Gly Val 
            180                 185                 190         


Ser Phe Lys Ala Gly Gly Pro Ile Thr Tyr Lys Ile Met Asn Glu Val 
        195                 200                 205             


Lys Val Leu Ala Tyr Phe Val Asn Gly Thr Ala Gln Thr Val Ile Pro 
    210                 215                 220                 


Cys Asp Gly Ser Pro Arg Gly Leu Leu Ala Cys Gln Tyr Asn Thr Gly 
225                 230                 235                 240 


Asn Phe Ser Asp Gly Phe Tyr Pro Tyr Thr Asn Ser Ser Leu Val Lys 
                245                 250                 255     


Glu Arg Phe Ile Val Tyr Arg Glu Ser Ser Val Asn Thr Ile Cys Val 
            260                 265                 270         


Leu Thr Asn Phe Thr Phe Ser Asn Val Ser Asn Ala Leu Pro Asn Thr 
        275                 280                 285             


Gly Asn Val His Ser Ile Val Leu His Gln Thr Gln Thr Ala Gln Ser 
    290                 295                 300                 


Gly Tyr Tyr Asn Leu Asn Phe Ser Phe Leu Ser Gly Phe Arg Tyr Val 
305                 310                 315                 320 


Glu Ser Asp Phe Met Tyr Gly Ser Tyr His Pro Lys Cys Ser Phe Arg 
                325                 330                 335     


Pro Glu Thr Ile Asn Asn Gly Leu Trp Phe Asn Ser Leu Ser Val Ser 
            340                 345                 350         


Leu Gly Tyr Gly Pro Leu Gln Gly Gly Cys Lys Gln Ser Val Phe Asn 
        355                 360                 365             


Asn Lys Ala Thr Cys Cys Tyr Ala Tyr Ser Tyr Asn Gly Pro Thr Leu 
    370                 375                 380                 


Cys Lys Gly Val Tyr Ser Gly Glu Leu Gln Lys Thr Phe Glu Cys Gly 
385                 390                 395                 400 


Leu Leu Val Phe Val Thr Lys Ser Asp Gly Ser Arg Ile Gln Thr Arg 
                405                 410                 415     


Asn Glu Pro Leu Val Leu Thr Gln His Asn Tyr Asn Asn Ile Thr Leu 
            420                 425                 430         


Asn Lys Cys Val Glu Tyr Asn Ile Tyr Gly Arg Val Gly Gln Gly Leu 
        435                 440                 445             


Ile Thr Asn Ile Thr Asp Ser Ala Ala Asn His Gly Tyr Leu Ala Asp 
    450                 455                 460                 


Gly Gly Leu Ala Val Leu Asp Thr Ser Gly Ala Ile Asp Val Phe Val 
465                 470                 475                 480 


Val Gln Gly Val Tyr Gly Leu Asn Tyr Tyr Lys Val Asn Pro Cys Glu 
                485                 490                 495     


Asp Val Asn Gln Gln Phe Val Val Ser Gly Gly Gln Leu Val Gly Ile 
            500                 505                 510         


Leu Thr Ser Arg Asn Glu Thr Gly Ser Gln Pro Ile Glu Asn Arg Phe 
        515                 520                 525             


Tyr Val Lys Phe Ser Asn Ser Arg Arg Arg Thr Gly Arg Ser Thr Ile 
    530                 535                 540                 


Ala Asn Val Thr Asn Cys Pro Tyr Val Ser Tyr Gly Lys Phe Cys Ile 
545                 550                 555                 560 


Lys Pro Asp Gly Ser Val Leu Glu Ile Val Pro Gln Glu Ile Glu His 
                565                 570                 575     


Phe Val Ala Pro Leu Leu Asn Val Thr Glu His Val Leu Ile Pro Asn 
            580                 585                 590         


Ser Phe Asn Leu Thr Val Thr Asp Glu Tyr Ile Gln Thr Arg Met Asp 
        595                 600                 605             


Lys Ile Gln Ile Asn Cys Leu Gln Tyr Val Cys Gly Asn Ser Ile Glu 
    610                 615                 620                 


Cys Arg Lys Leu Phe Gln Gln Tyr Gly Pro Val Cys Asp Asn Ile Leu 
625                 630                 635                 640 


Ser Val Val Asn Thr Val Gly Gln Arg Glu Asp Met Glu Leu Leu Ser 
                645                 650                 655     


Phe Tyr Ser Ser Thr Lys Pro Lys Asp Tyr Asn Val Pro Ile Phe Ser 
            660                 665                 670         


Asn Val Ser Thr Gly Asp Phe Asn Ile Ser Leu Leu Leu Thr Pro Pro 
        675                 680                 685             


Asn Ser Pro Thr Gly Arg Ser Phe Ile Glu Asp Ile Leu Phe Thr Ser 
    690                 695                 700                 


Val Glu Ser Val Gly Leu Pro Thr Asp Glu Glu Tyr Lys Lys Cys Thr 
705                 710                 715                 720 


Ala Gly Pro Leu Gly Phe Val Lys Asp Leu Val Cys Ala Arg Glu Tyr 
                725                 730                 735     


Asn Gly Leu Leu Val Leu Pro Pro Ile Ile Thr Ala Asp Met Gln Thr 
            740                 745                 750         


Met Tyr Thr Ser Thr Leu Val Ala Ser Met Ala Leu Gly Gly Ile Thr 
        755                 760                 765             


Ala Ala Gly Ala Ile Pro Phe Ala Thr Gln Leu Gln Ala Arg Ile Asn 
    770                 775                 780                 


His Leu Gly Ile Thr Gln Ser Leu Leu Leu Lys Asn Gln Glu Lys Ile 
785                 790                 795                 800 


Ala Ala Ser Phe Asn Lys Ala Ile Gly His Met Gln Glu Gly Phe Arg 
                805                 810                 815     


Ser Thr Ser Leu Ala Leu Gln Gln Ile Gln Asp Val Val Asn Lys Gln 
            820                 825                 830         


Ser Ser Ile Leu Thr Glu Thr Met Ala Ser Leu Asn Lys Asn Phe Gly 
        835                 840                 845             


Ala Ile Ser Ser Val Leu Gln Asp Ile Tyr Gln Gln Leu Asp Ala Ile 
    850                 855                 860                 


Gln Ala Asp Ala Gln Val Asp Arg Ile Ile Thr Gly Arg Leu Ser Ser 
865                 870                 875                 880 


Leu Ser Val Leu Ala Ser Ala Lys Gln Ser Glu Tyr Tyr Arg Val Ser 
                885                 890                 895     


Gln Gln Arg Glu Leu Ala Thr Gln Lys Ile Asn Glu Cys Val Lys Ser 
            900                 905                 910         


Gln Ser Thr Arg Tyr Ser Phe Cys Gly Asn Gly Arg His Val Leu Thr 
        915                 920                 925             


Ile Pro Gln Asn Ala Pro Asn Gly Ile Val Phe Ile His Phe Thr Tyr 
    930                 935                 940                 


Thr Pro Glu Ser Phe Val Asn Val Thr Ala Ile Val Gly Phe Cys Val 
945                 950                 955                 960 


Asn Pro Pro Asn Ala Ser Gln Tyr Ala Leu Val Pro Ala Asn Gly Arg 
                965                 970                 975     


Gly Ile Phe Ile Gln Val Asn Gly Ser Tyr Tyr Ile Thr Ala Arg Asp 
            980                 985                 990         


Met Tyr Met Pro Arg Asp Ile Thr  Ala Gly Asp Ile Val  Thr Leu Thr 
        995                 1000                 1005             


Ser Cys  Gln Ala Asn Tyr Val  Ser Val Asn Arg Thr  Val Ile Thr 
    1010                 1015                 1020             


Thr Phe  Val Asp Asn Asp Asp  Phe Asp Phe Asp Asp  Glu Leu Ser 
    1025                 1030                 1035             


Lys Trp  Trp Asn Asp Thr Lys  His Glu Leu Pro Asp  Phe Asp Glu 
    1040                 1045                 1050             


Phe Asn  Tyr Thr Ile Pro Val  Leu Asn Ile Ser Asn  Glu Ile Asp 
    1055                 1060                 1065             


Ile Ile  Gln Glu Val Ile Arg  Gly Leu Asn Asp Ser  Leu Ile Asp 
    1070                 1075                 1080             


Leu Glu  Ala Leu Ser Ile Leu  Lys Thr Tyr Ile Lys  Trp Pro Trp 
    1085                 1090                 1095             


Tyr Val  Trp Leu Ala Ile Ala  Phe Leu Thr Ile Ile  Phe Ile Leu 
    1100                 1105                 1110             


Val Leu  Cys Trp Ile Phe Phe  Met Thr Gly Cys Cys  Gly Cys Cys 
    1115                 1120                 1125             


Cys Gly  Cys Phe Gly Ile Met  Pro Leu Met Ser Lys  Cys Gly Lys 
    1130                 1135                 1140             


Lys Ser  Ser Tyr Tyr Thr Thr  Phe Asp Asn Asp Val  Val 
    1145                 1150                 1155     


<210>  6
<211>  1156
<212>  PRT
<213>  Avian infectious bronchitis virus

<400>  6

Met Leu Val Lys Ser Leu Phe Ile Val Thr Leu Leu Phe Ala Leu Cys 
1               5                   10                  15      


Ser Ala Ala Leu Phe Asp Asn Asn Gln Ala Val Tyr Tyr Tyr Gln Ser 
            20                  25                  30          


Ala Phe Arg Pro Ser Ser Gly Trp His Lys His Gly Gly Ala Tyr Ala 
        35                  40                  45              


Val Ala Asn Val Ser Leu Glu Tyr Ala Asn Ala Gly Ser Ser Thr His 
    50                  55                  60                  


Cys Thr Ala Gly Ala Ile Tyr Trp Ser Lys Asn Phe Thr Ala Ser Ser 
65                  70                  75                  80  


Val Ala Met Thr Ala Pro Gly Thr Gly Met Ser Trp Ser Thr Ala Gln 
                85                  90                  95      


Phe Cys Thr Ala His Cys Asn Phe Ser Asp Phe Thr Val Phe Val Thr 
            100                 105                 110         


His Cys Tyr Lys Ser Gly Asp Val Cys Pro Leu Thr Gly Leu Ile Pro 
        115                 120                 125             


Ser Gly Tyr Ile Arg Ile Ser Ala Met Thr Lys Gly Thr Thr Ser Leu 
    130                 135                 140                 


Phe Tyr Asn Leu Thr Val Pro Val Thr Lys Tyr Pro Lys Phe Lys Ser 
145                 150                 155                 160 


Leu Gln Cys Val Asp Asn Phe Thr Ser Val Tyr Leu Asn Gly Asp Leu 
                165                 170                 175     


Val Phe Thr Ser Asn Glu Thr Lys Asp Val Ser Ala Ala Gly Val His 
            180                 185                 190         


Phe Lys Ala Gly Gly Pro Ile Thr Tyr Lys Val Met Glu Lys Val Asp 
        195                 200                 205             


Val Leu Ala Tyr Phe Val Asn Gly Thr Ala Gln Asp Val Ile Leu Cys 
    210                 215                 220                 


Asp Asn Ser Pro Arg Gly Leu Leu Ala Cys Gln Tyr Asn Thr Gly Asn 
225                 230                 235                 240 


Phe Ser Asp Gly Phe Tyr Pro Phe Thr Asn Ile Ser Leu Val Lys Glu 
                245                 250                 255     


Lys Phe Ile Val Tyr Arg Glu Thr Ser Val Asn Thr Thr Cys Val Leu 
            260                 265                 270         


Thr Asn Phe Thr Phe Thr Asn Val Ser Asn Ala Leu Pro Asn Thr Gly 
        275                 280                 285             


Gly Val Asn Thr Ile Asn Ile Tyr Gln Thr Gln Thr Ala Gln Ser Gly 
    290                 295                 300                 


Cys Tyr Asn Phe Asn Phe Ser Phe Leu Ser Ser Phe Val Tyr Lys Gln 
305                 310                 315                 320 


Ser Asp Phe Met Tyr Gly Ser Tyr His Pro Lys Cys Asp Phe Arg Pro 
                325                 330                 335     


Glu Thr Ile Asn Asn Gly Leu Trp Phe Asn Ser Leu Ser Val Ser Leu 
            340                 345                 350         


Ala Tyr Gly Pro Leu Gln Gly Gly Cys Lys Gln Ser Val Phe Ser Asn 
        355                 360                 365             


Arg Ala Thr Cys Cys Tyr Ala Tyr Ser Tyr Asn Gly Pro Arg Leu Cys 
    370                 375                 380                 


Lys Gly Val Tyr Ile Gly Glu Leu Gln Gln Tyr Phe Glu Cys Gly Leu 
385                 390                 395                 400 


Leu Val Tyr Val Thr Lys Ser Asp Gly Ser Arg Ile Gln Thr Arg Asn 
                405                 410                 415     


Glu Pro Leu Val Leu Thr His His Asn Tyr Asn Asn Ile Thr Leu Asp 
            420                 425                 430         


Arg Cys Val Glu Tyr Asn Ile Tyr Gly Arg Ser Gly Gln Gly Phe Ile 
        435                 440                 445             


Thr Asn Val Thr Ala Ala Ala Ala Asn Tyr Asn Tyr Leu Ala Asp Gly 
    450                 455                 460                 


Gly Leu Ala Ile Leu Asp Thr Ser Gly Ala Ile Asp Ile Phe Val Val 
465                 470                 475                 480 


Gln Gly Glu Tyr Gly Pro Asn Tyr Tyr Lys Val Asn Pro Cys Glu Asp 
                485                 490                 495     


Val Asn Gln Gln Phe Val Val Ser Gly Gly Gly Ile Val Gly Val Leu 
            500                 505                 510         


Thr Ser His Asn Glu Thr Gly Ser Gln Gln Leu Glu Asn Leu Phe Tyr 
        515                 520                 525             


Val Lys Leu Thr Asn Ser Thr Arg Arg Thr Arg Arg Ser Thr Ile Ala 
    530                 535                 540                 


Asn Val Thr Thr Cys Pro Tyr Val Ser Tyr Gly Arg Phe Cys Ile Lys 
545                 550                 555                 560 


Pro Asp Gly Leu Val Ser Glu Ile Val Pro Gln Glu Leu Asp Tyr Phe 
                565                 570                 575     


Val Ala Pro Leu Leu Asn Val Thr Glu His Val Leu Ile Pro Asn Ser 
            580                 585                 590         


Phe Asn Leu Thr Val Thr Asp Glu Tyr Ile Gln Thr Arg Met Glu Lys 
        595                 600                 605             


Val Gln Ile Asn Cys Leu Gln Tyr Val Cys Gly Asn Ser Ile Glu Cys 
    610                 615                 620                 


Arg Asn Leu Phe Gln Gln Tyr Gly Pro Val Cys Asp Asn Ile Leu Ser 
625                 630                 635                 640 


Ile Val Asn Ser Val Gly Gln Arg Glu Asp Met Glu Ser Leu Thr Phe 
                645                 650                 655     


Tyr Ser Ser Thr Lys Pro Lys Gly Tyr Asn Thr Pro Ile Phe Ser Asn 
            660                 665                 670         


Ile Ser Thr Gly Asp Phe Asn Ile Ser Leu Met Leu Thr Pro Pro Ser 
        675                 680                 685             


Ser Pro Ser Gly Arg Ser Phe Ile Glu Asp Leu Leu Phe Thr Ser Val 
    690                 695                 700                 


Glu Thr Val Gly Leu Pro Thr Asp Ala Glu Tyr Lys Lys Cys Thr Ala 
705                 710                 715                 720 


Gly Pro Leu Gly Thr Leu Lys Asp Leu Ile Cys Ala Arg Glu Tyr Asn 
                725                 730                 735     


Gly Leu Leu Val Leu Pro Pro Ile Ile Thr Ala Asp Met Gln Thr Met 
            740                 745                 750         


Tyr Thr Ala Ser Leu Val Gly Ala Met Ala Phe Gly Gly Ile Thr Ser 
        755                 760                 765             


Ala Ala Ala Ile Pro Phe Ala Thr Gln Ile Gln Ala Arg Ile Asn His 
    770                 775                 780                 


Leu Gly Ile Thr Gln Ser Leu Leu Met Lys Asn Gln Glu Lys Ile Ala 
785                 790                 795                 800 


Ala Ser Phe Asn Lys Ala Ile Gly His Met Gln Glu Gly Phe Arg Ser 
                805                 810                 815     


Thr Ser Leu Ala Leu Gln Gln Ile Gln Asp Val Val Asn Lys Gln Ser 
            820                 825                 830         


Ala Ile Leu Thr Glu Thr Met Asn Ser Leu Asn Lys Asn Phe Gly Ala 
        835                 840                 845             


Ile Thr Ser Val Ile Gln Asp Ile Tyr Ala Gln Leu Asp Ala Ile Gln 
    850                 855                 860                 


Ala Asp Ala Gln Val Asp Arg Leu Ile Thr Gly Arg Leu Ser Ser Leu 
865                 870                 875                 880 


Ser Val Leu Ala Ser Ala Lys Gln Ser Glu Tyr Ile Arg Val Ser Gln 
                885                 890                 895     


Gln Arg Glu Leu Ala Thr Gln Lys Ile Asn Glu Cys Val Lys Ser Gln 
            900                 905                 910         


Ser Asn Arg Tyr Gly Phe Cys Gly Ser Gly Arg His Val Leu Ser Ile 
        915                 920                 925             


Pro Gln Asn Ala Pro Asn Gly Ile Val Phe Ile His Phe Thr Tyr Thr 
    930                 935                 940                 


Pro Glu Ser Phe Val Asn Val Thr Ala Ile Val Gly Phe Cys Val Ser 
945                 950                 955                 960 


Pro Ala Asn Ala Ser Gln Tyr Ala Ile Val Pro Ala Asn Gly Arg Gly 
                965                 970                 975     


Ile Phe Ile Gln Val Asn Gly Thr Tyr Tyr Ile Thr Ala Arg Asp Met 
            980                 985                 990         


Tyr Met Pro Arg Asp Ile Thr Ala  Gly Asp Ile Val Thr  Leu Thr Ser 
        995                 1000                 1005             


Cys Gln  Ala Asn Tyr Val Asn  Val Asn Lys Thr Val  Ile Thr Thr 
    1010                 1015                 1020             


Phe Val  Glu Asp Asp Asp Phe  Asp Phe Asp Asp Glu  Leu Ser Lys 
    1025                 1030                 1035             


Trp Trp  Asn Glu Thr Lys His  Glu Ile Pro Asp Phe  Asp Glu Phe 
    1040                 1045                 1050             


Asn Tyr  Thr Val Pro Ile Leu  Asn Ile Ser Ser Glu  Ile Asp Arg 
    1055                 1060                 1065             


Ile Gln  Gly Val Ile Gln Gly  Leu Asn Asp Ser Leu  Ile Asn Leu 
    1070                 1075                 1080             


Glu Glu  Leu Ser Ile Ile Lys  Thr Tyr Ile Lys Trp  Pro Trp Tyr 
    1085                 1090                 1095             


Val Trp  Leu Ala Ile Gly Phe  Ala Ile Ile Ile Phe  Ile Leu Ile 
    1100                 1105                 1110             


Leu Gly  Trp Val Phe Phe Met  Thr Gly Cys Cys Gly  Cys Cys Cys 
    1115                 1120                 1125             


Gly Cys  Phe Gly Ile Ile Pro  Leu Met Ser Lys Cys  Gly Lys Lys 
    1130                 1135                 1140             


Ser Ser  Tyr Tyr Thr Thr Phe  Asp Asn Asp Val Val  Thr 
    1145                 1150                 1155     


<210>  7
<211>  1169
<212>  PRT
<213>  Avian infectious bronchitis virus

<400>  7

Met Leu Val Gln Pro Leu Leu Leu Val Thr Leu Leu Cys Ala Leu Cys 
1               5                   10                  15      


Ser Ala Ser Leu Tyr Asn Asn Asp Ser Tyr Val Tyr Tyr Tyr Gln Ser 
            20                  25                  30          


Ala Phe Arg Pro Phe Asn Gly Trp His Leu His Gly Gly Ala Tyr Ala 
        35                  40                  45              


Val Val Asn Val Ser Gln Glu Thr Ala Asn Ala Gly Ser Ser Pro Ser 
    50                  55                  60                  


Cys Thr Ala Gly Ala Ile Tyr Trp Ser Lys Asn Phe Thr Ala Ser Ser 
65                  70                  75                  80  


Val Ala Met Thr Ala Pro Leu Gln Gly Met Gln Trp Ser Thr Ile Gln 
                85                  90                  95      


Phe Cys Thr Ala His Cys Asn Phe Thr Asn Ile Val Val Phe Val Thr 
            100                 105                 110         


His Cys Tyr Lys Ser Gly Ser Thr Val Cys Pro Leu Thr Gly Leu Ile 
        115                 120                 125             


Pro Gln Asn His Ile Arg Ile Ser Ala Met Lys Gln Gly Asn Asn Gly 
    130                 135                 140                 


Pro Ser Gly Leu Phe Tyr Asn Leu Thr Val Pro Val Thr Lys Tyr Ser 
145                 150                 155                 160 


Lys Phe Lys Ser Leu Gln Cys Val Asn Asn Gln Thr Ser Val Tyr Leu 
                165                 170                 175     


Asn Gly Asp Leu Val Phe Thr Ser Asn Glu Thr Lys Asp Val Ser Gly 
            180                 185                 190         


Ala Gly Val Tyr Phe Lys Ala Gly Gly Pro Ile Thr Tyr Lys Val Met 
        195                 200                 205             


Arg Glu Val Lys Ala Leu Ala Tyr Phe Val Asn Gly Thr Ala His Asp 
    210                 215                 220                 


Val Ile Leu Cys Asp Gly Ser Pro Arg Gly Leu Leu Ala Cys Gln Tyr 
225                 230                 235                 240 


Asn Thr Gly Lys Phe Ser Asp Gly Phe Tyr Pro Phe Thr Asn Asp Thr 
                245                 250                 255     


Leu Val Lys Glu Lys Phe Ile Val Tyr Arg Glu Asn Ser Val Asn Thr 
            260                 265                 270         


Thr Cys Thr Leu Thr Asn Phe Thr Phe Tyr Asn Glu Ser Asn Ala Leu 
        275                 280                 285             


Pro Asn Asn Gly Gly Val Asp Thr Ile Gln Leu Tyr Gln Thr His Thr 
    290                 295                 300                 


Ala Gln Ser Gly Tyr Tyr Asn Phe Asn Phe Ser Phe Leu Ser Ser Phe 
305                 310                 315                 320 


Gln Tyr Val Glu Ser Asn Phe Met Tyr Gly Ser Tyr His Pro Lys Cys 
                325                 330                 335     


Gly Phe Arg Pro Glu Ser Ile Asn Asn Gly Leu Trp Phe Asn Ser Leu 
            340                 345                 350         


Ser Val Ser Leu Ala Tyr Gly Pro Leu Gln Gly Gly Cys Lys Gln Ser 
        355                 360                 365             


Val Phe His Gly Arg Ala Thr Cys Cys Tyr Ala Tyr Ser Tyr Asn Gly 
    370                 375                 380                 


Pro Thr Leu Cys Lys Gly Val Tyr Ser Gly Glu Leu Thr Arg Ser Tyr 
385                 390                 395                 400 


Gln Cys Gly Leu Leu Val Phe Val Thr Lys Ser Asp Gly Ser Arg Ile 
                405                 410                 415     


Gln Thr Ser Thr Lys Pro Ile Val Leu Thr Gln His Asn Tyr Asn Asn 
            420                 425                 430         


Ile Thr Leu Asp Arg Cys Val Glu Tyr Asn Ile Tyr Gly Arg Val Gly 
        435                 440                 445             


Gln Gly Phe Ile Thr Asn Val Thr Glu Ser Ala Ala Ala Phe Asn Tyr 
    450                 455                 460                 


Leu Glu Asp Gly Gly Leu Ala Ile Leu Asp Thr Ser Gly Ala Ile Asp 
465                 470                 475                 480 


Ile Phe Val Val Gln Gly Glu Tyr Gly Phe Asn Tyr Tyr Lys Val Asn 
                485                 490                 495     


Pro Cys Glu Asp Val Asn Gln Gln Phe Val Val Ser Gly Gly Asn Leu 
            500                 505                 510         


Val Gly Ile Leu Thr Ser Ile Asn Gln Thr Gly Ser Gln Ser Ile Glu 
        515                 520                 525             


Asn Gln Phe Tyr Val Lys Leu Thr Asn Gly Ser Arg Arg Ser Arg Arg 
    530                 535                 540                 


Ser Val Ser Glu Asn Val Thr Ser Cys Pro Tyr Val Ser Tyr Gly Lys 
545                 550                 555                 560 


Phe Cys Ile Lys Pro Asp Gly Ser Leu Ser Thr Ile Val Pro Lys Glu 
                565                 570                 575     


Leu Glu Gln Phe Val Ala Pro Leu Leu Asn Val Thr Glu His Val Leu 
            580                 585                 590         


Ile Pro Asp Ser Phe Asn Leu Thr Val Thr Asp Glu Tyr Ile Gln Thr 
        595                 600                 605             


Arg Met Asp Lys Val Gln Ile Asn Cys Leu Gln Tyr Val Cys Gly Asn 
    610                 615                 620                 


Ser Phe Glu Cys Arg Lys Leu Phe Gln Gln Tyr Gly Pro Val Cys Asp 
625                 630                 635                 640 


Asn Ile Leu Ser Val Val Asn Ser Val Gly Gln Lys Glu Asp Met Glu 
                645                 650                 655     


Leu Leu Ser Phe Tyr Ser Ser Thr Lys Pro Ser Gly Ile Ser Gln Pro 
            660                 665                 670         


Leu Phe Asn Asn Phe Ser Thr Gly Asp Phe Asn Ile Ser Leu Leu Leu 
        675                 680                 685             


Thr Ser Pro Ser Ser Pro Ser Gly Arg Ser Phe Ile Glu Asp Leu Leu 
    690                 695                 700                 


Phe Thr Ser Val Glu Ser Val Gly Leu Pro Thr Asp Glu Ala Tyr Lys 
705                 710                 715                 720 


Lys Cys Thr Ser Gly Pro Leu Gly Phe Val Lys Asp Leu Val Cys Ala 
                725                 730                 735     


Arg Glu Tyr Asn Gly Leu Leu Val Leu Pro Pro Ile Ile Thr Ala Glu 
            740                 745                 750         


Met Gln Thr Met Tyr Thr Ser Ser Leu Val Ala Ser Met Ala Leu Gly 
        755                 760                 765             


Gly Ile Thr Ala Ala Gly Ala Ile Pro Phe Ala Thr Gln Leu Gln Ala 
    770                 775                 780                 


Arg Ile Asn His Leu Gly Ile Thr Gln Ser Leu Leu Met Lys Asn Gln 
785                 790                 795                 800 


Glu Lys Ile Ala Ala Ser Phe Asn Arg Ala Ile Gly His Met Gln Glu 
                805                 810                 815     


Gly Phe Lys Ser Thr Ser Leu Ala Leu Gln Gln Ile Gln Asp Val Val 
            820                 825                 830         


Asn Lys Gln Ser Ala Ile Leu Thr Glu Thr Met Ala Ser Leu Asn Lys 
        835                 840                 845             


Asn Phe Gly Ala Ile Ser Ser Val Leu Gln Asp Ile Tyr Gln Gln Leu 
    850                 855                 860                 


Asp Val Ile Gln Ala Asp Ala Gln Val Asp Arg Ile Ile Thr Gly Arg 
865                 870                 875                 880 


Leu Ser Ser Leu Ser Val Leu Ala Ser Ala Lys Gln Ser Glu Tyr Ile 
                885                 890                 895     


Ala Val Ser Gln Gln Arg Ala Leu Ala Thr Gln Lys Ile Asn Glu Cys 
            900                 905                 910         


Val Lys Ser Gln Ser Thr Arg Tyr Ser Phe Cys Gly Asn Gly Arg His 
        915                 920                 925             


Val Leu Thr Ile Pro Gln Asn Ala Pro Asn Gly Ile Val Phe Ile His 
    930                 935                 940                 


Phe Thr Tyr Thr Pro Glu Ser Phe Val Asn Val Thr Ala Ile Val Gly 
945                 950                 955                 960 


Phe Cys Val Lys Pro Pro Asn Ala Ser His Tyr Ala Ile Val Pro Val 
                965                 970                 975     


Asn Gly Arg Gly Ile Phe Ile Gln Val Asn Gly Thr Tyr Tyr Ile Thr 
            980                 985                 990         


Ser Arg Asp Met Tyr Met Pro Arg  Asn Ile Thr Ala Gly  Asp Ile Val 
        995                 1000                 1005             


Thr Leu  Thr Ser Cys Gln Ala  Asn Tyr Val Ser Val  Asn Lys Thr 
    1010                 1015                 1020             


Val Ile  Ser Thr Phe Val Glu  Asp Asp Asp Phe Asp  Phe Asp Asp 
    1025                 1030                 1035             


Glu Leu  Ser Lys Trp Trp Asn  Asp Thr Lys His Glu  Leu Pro Asp 
    1040                 1045                 1050             


Phe Asp  Glu Phe Asn Tyr Thr  Ile Pro Val Leu Asn  Ile Ser Asn 
    1055                 1060                 1065             


Glu Ile  Asp Arg Ile Gln Gly  Val Ile Gln Gly Leu  Asn Asp Ser 
    1070                 1075                 1080             


Leu Ile  Asp Leu Glu Thr Leu  Ser Ile Leu Lys Thr  Tyr Ile Lys 
    1085                 1090                 1095             


Trp Pro  Trp Tyr Val Trp Leu  Ala Ile Phe Phe Ala  Ile Val Ile 
    1100                 1105                 1110             


Phe Ile  Leu Ile Ile Gly Trp  Val Phe Phe Met Thr  Gly Cys Cys 
    1115                 1120                 1125             


Gly Cys  Cys Cys Gly Cys Phe  Gly Ile Ile Pro Leu  Met Asn Lys 
    1130                 1135                 1140             


Cys Gly  Lys Lys Ser Ser Tyr  Tyr Thr Thr Phe Asp  Asn Asp Val 
    1145                 1150                 1155             


Val Thr  Glu Gln Tyr Arg Pro  Lys Lys Ser Val 
    1160                 1165                 


<210>  8
<211>  1159
<212>  PRT
<213>  Avian infectious bronchitis virus

<400>  8

Met Leu Val Lys Ser Leu Phe Leu Val Thr Ile Leu Phe Ala Leu Cys 
1               5                   10                  15      


Ser Ala Asn Leu Tyr Asp Asn Glu Ser Phe Val Tyr Tyr Tyr Gln Ser 
            20                  25                  30          


Ala Phe Arg Pro Gly His Gly Trp His Leu His Gly Gly Ala Tyr Ala 
        35                  40                  45              


Val Val Asn Val Ser Ser Glu Asn Asn Asn Ala Gly Thr Ala Pro Ser 
    50                  55                  60                  


Cys Thr Ala Gly Ala Ile Gly Tyr Ser Lys Asn Phe Ser Ala Ala Ser 
65                  70                  75                  80  


Val Ala Met Thr Ala Pro Leu Ser Gly Met Ser Trp Ser Ala Ser Ser 
                85                  90                  95      


Phe Cys Thr Ala His Cys Asn Phe Thr Ser Tyr Ile Val Phe Val Thr 
            100                 105                 110         


His Cys Phe Lys Ser Gly Ser Asn Ser Cys Pro Leu Thr Gly Leu Ile 
        115                 120                 125             


Pro Ser Gly Tyr Ile Arg Ile Ala Ala Met Lys His Gly Ser Arg Thr 
    130                 135                 140                 


Pro Gly His Leu Phe Tyr Asn Leu Thr Val Ser Val Thr Lys Tyr Pro 
145                 150                 155                 160 


Lys Phe Arg Ser Leu Gln Cys Val Asn Asn His Thr Ser Val Tyr Leu 
                165                 170                 175     


Asn Gly Asp Leu Val Phe Thr Ser Gly Tyr Thr Glu Asp Val Val Ala 
            180                 185                 190         


Ala Gly Val His Phe Lys Ser Gly Gly Pro Ile Thr Tyr Lys Val Met 
        195                 200                 205             


Arg Glu Val Lys Ala Leu Ala Tyr Phe Val Asn Gly Thr Ala His Asp 
    210                 215                 220                 


Val Ile Leu Cys Asp Asp Thr Pro Arg Gly Leu Leu Ala Cys Gln Tyr 
225                 230                 235                 240 


Asn Thr Gly Asn Phe Ser Asp Gly Phe Tyr Pro Phe Thr Asn Thr Ser 
                245                 250                 255     


Ile Val Lys Asp Lys Phe Ile Val Tyr Arg Glu Ser Ser Val Asn Thr 
            260                 265                 270         


Thr Cys Thr Leu Thr Asn Phe Thr Phe Ser Asn Glu Ser Gly Ala Pro 
        275                 280                 285             


Pro Asn Thr Gly Gly Val Asp Ser Phe Ile Leu Tyr Gln Thr Gln Thr 
    290                 295                 300                 


Ala Gln Ser Gly Tyr Tyr Asn Phe Asn Phe Ser Phe Leu Ser Ser Phe 
305                 310                 315                 320 


Val Tyr Arg Glu Ser Asn Tyr Met Tyr Gly Ser Tyr His Pro Arg Cys 
                325                 330                 335     


Ser Phe Arg Pro Glu Thr Leu Asn Gly Leu Trp Phe Asn Ser Leu Ser 
            340                 345                 350         


Val Ser Leu Thr Tyr Gly Pro Ile Gln Gly Gly Cys Lys Gln Ser Val 
        355                 360                 365             


Phe Asn Gly Lys Ala Thr Cys Cys Tyr Ala Tyr Ser Tyr Gly Gly Pro 
    370                 375                 380                 


Arg Ala Cys Lys Gly Val Tyr Arg Gly Glu Leu Thr Gln His Phe Glu 
385                 390                 395                 400 


Cys Gly Leu Leu Val Tyr Val Thr Lys Ser Asp Gly Ser Arg Ile Gln 
                405                 410                 415     


Thr Ala Thr Gln Pro Pro Val Leu Thr Gln Asn Phe Tyr Asn Asn Ile 
            420                 425                 430         


Thr Leu Gly Lys Cys Val Asp Tyr Asn Val Tyr Gly Arg Thr Gly Gln 
        435                 440                 445             


Gly Phe Ile Thr Asn Val Thr Asp Leu Ala Thr Ser His Asn Tyr Leu 
    450                 455                 460                 


Ala Asp Gly Gly Leu Ala Ile Leu Asp Thr Ser Gly Ala Ile Asp Ile 
465                 470                 475                 480 


Phe Val Val Gln Gly Glu Tyr Gly Pro Asn Tyr Tyr Lys Val Asn Leu 
                485                 490                 495     


Cys Glu Asp Val Asn Gln Gln Phe Val Val Ser Gly Gly Lys Leu Val 
            500                 505                 510         


Gly Ile Leu Thr Ser Arg Asn Glu Thr Gly Ser Gln Pro Leu Glu Asn 
        515                 520                 525             


Gln Phe Tyr Ile Lys Ile Thr Asn Gly Thr His Arg Ser Arg Arg Ser 
    530                 535                 540                 


Val Asn Glu Asn Val Thr Asn Cys Pro Tyr Val Ser Tyr Gly Lys Phe 
545                 550                 555                 560 


Cys Ile Lys Pro Asp Gly Ser Val Ser Pro Ile Val Pro Lys Glu Leu 
                565                 570                 575     


Glu Gln Phe Val Ala Pro Leu Leu Asn Val Thr Glu Asn Val Leu Ile 
            580                 585                 590         


Pro Asn Ser Phe Asn Leu Thr Val Thr Asp Glu Tyr Ile Gln Thr His 
        595                 600                 605             


Met Asp Lys Ile Gln Ile Asn Cys Leu Gln Tyr Val Cys Gly Asn Ser 
    610                 615                 620                 


Leu Ala Cys Arg Lys Leu Phe Gln Gln Tyr Gly Pro Val Cys Asp Asn 
625                 630                 635                 640 


Ile Leu Ser Val Val Asn Ser Val Gly Gln Lys Glu Asp Met Glu Leu 
                645                 650                 655     


Leu Ser Phe Tyr Ser Ser Thr Lys Pro Ser Gly Phe Asn Thr Pro Val 
            660                 665                 670         


Phe Ser Asn Leu Ser Thr Gly Glu Phe Asn Ile Ser Leu Leu Leu Thr 
        675                 680                 685             


Thr Pro Ser Ser Pro Arg Gly Arg Ser Phe Ile Glu Asp Leu Leu Phe 
    690                 695                 700                 


Thr Ser Val Glu Ser Val Gly Leu Pro Thr Asp Glu Ala Tyr Lys Lys 
705                 710                 715                 720 


Cys Thr Ala Gly Pro Leu Gly Phe Leu Lys Asp Leu Ala Cys Ala Arg 
                725                 730                 735     


Glu Tyr Asn Gly Leu Leu Val Leu Pro Pro Ile Ile Thr Ala Glu Met 
            740                 745                 750         


Gln Thr Leu Tyr Thr Ser Ser Leu Val Val Ser Met Ala Phe Gly Gly 
        755                 760                 765             


Ile Thr Ser Ala Gly Ala Ile Pro Phe Ala Thr Gln Leu Gln Ala Arg 
    770                 775                 780                 


Ile Asn His Leu Gly Ile Thr Gln Ser Leu Leu Leu Lys Asn Gln Glu 
785                 790                 795                 800 


Lys Ile Ala Ala Ser Phe Asn Lys Ala Ile Gly His Met Gln Glu Gly 
                805                 810                 815     


Phe Arg Ser Thr Ser Leu Ala Leu Gln Gln Ile Gln Asp Val Val Asn 
            820                 825                 830         


Lys Gln Ser Ala Ile Leu Thr Glu Thr Met Ala Ser Leu Asn Lys Asn 
        835                 840                 845             


Phe Gly Ala Ile Ser Ser Val Ile Gln Glu Ile Tyr Gln Gln Leu Asp 
    850                 855                 860                 


Ala Ile Gln Ala Asn Ala Gln Val Asp Arg Leu Ile Thr Gly Arg Leu 
865                 870                 875                 880 


Ser Ser Leu Ser Val Leu Ala Ser Ala Lys Gln Ala Glu Tyr Ile Arg 
                885                 890                 895     


Val Ser Gln Gln Arg Glu Leu Ala Thr Gln Lys Ile Asn Glu Cys Val 
            900                 905                 910         


Lys Ser Gln Ser Ile Arg Tyr Ser Phe Cys Gly Asn Gly Arg His Val 
        915                 920                 925             


Leu Thr Ile Pro Gln Asn Ala Pro Asn Gly Ile Val Phe Ile His Phe 
    930                 935                 940                 


Ser Tyr Thr Pro Asp Ser Phe Val Asn Val Thr Ala Ile Val Gly Phe 
945                 950                 955                 960 


Cys Val Lys Pro Ala Asn Ala Ser Gln Tyr Ala Ile Val Pro Ala Asn 
                965                 970                 975     


Gly Arg Gly Ile Phe Ile Gln Val Asn Gly Ser Tyr Tyr Ile Thr Ala 
            980                 985                 990         


Arg Asp Met Tyr Met Pro Arg Ala  Ile Thr Ala Gly Asp  Ile Val Thr 
        995                 1000                 1005             


Leu Thr  Ser Cys Gln Ala Asn  Tyr Val Ser Val Asn  Lys Thr Val 
    1010                 1015                 1020             


Ile Thr  Thr Phe Val Asp Asn  Asp Asp Phe Asp Phe  Asn Asp Glu 
    1025                 1030                 1035             


Leu Ser  Lys Trp Trp Asn Asp  Thr Lys His Glu Leu  Pro Asp Phe 
    1040                 1045                 1050             


Asp Lys  Phe Asn Tyr Thr Val  Pro Ile Leu Asp Ile  Asp Ser Glu 
    1055                 1060                 1065             


Ile Asp  Arg Ile Gln Gly Val  Ile Gln Gly Leu Asn  Asp Ser Leu 
    1070                 1075                 1080             


Ile Asp  Leu Glu Lys Leu Ser  Ile Leu Lys Thr Tyr  Ile Lys Trp 
    1085                 1090                 1095             


Pro Trp  Tyr Val Trp Leu Ala  Ile Ala Phe Ala Thr  Ile Ile Phe 
    1100                 1105                 1110             


Ile Leu  Ile Leu Gly Trp Val  Phe Phe Met Thr Gly  Cys Cys Gly 
    1115                 1120                 1125             


Cys Cys  Cys Gly Cys Phe Gly  Ile Met Pro Leu Met  Ser Lys Cys 
    1130                 1135                 1140             


Gly Lys  Lys Ser Ser Tyr Tyr  Thr Thr Phe Asp Asn  Asp Val Val 
    1145                 1150                 1155             


Thr 
    


<210>  9
<211>  11398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid Sequence

<400>  9
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt ggagatcggt acttcgcgaa      420

tgcgtcgaga tcggccgccc gggtaatacg actcactata gggacttaag atagatatta      480

atatatatct attgcactag ccttgcgcta gatttcaaac ttaacaaaac ggacttaaat      540

acctacagct ggtccccata ggtgttccat tgcagtgcac tttagtgccc tggatggcac      600

ctggccacct gtcaggtttt tgttgttaaa atatcattgt tgctggtatc actgcttgtt      660

ttgccgtgtc tcactttata catccgttgc ttgggctacc tagtatccag cgtcctacgg      720

gcgccgtggt cggttcgagt gcgaaggacc tctggttcat ctagcggtag gcgggtgtgt      780

ggaagtagcg cttcagacgt actggttctg ttgcgtgaaa cgcggggtca cctcccccca      840

catacctcta agggcttttg agcctagcgt tgggctacgt tctcgcacaa ggtcggctat      900

acgacgtttg tagggggtag tgccaaacaa cccctgaggt gacaggttct ggtggtgttt      960

cgaaaacaac aatgtgtgtg ccgcataata tgcgcgttat gcattttgga gcaggtagtg     1020

ataaaggagt ggcgcctggt agtactgttc ttaaacagtg gctccccgaa ggaacactcc     1080

ttgtcgataa tgatattgta gattatgttt ctgacgcaca cgtttctgtg ctttcagatt     1140

gcaataaata taagacagag cacaagtttg atcttgtgat atctgatatg tatacagaca     1200

atgattcaaa aagaaagcat gaaggcgtga tagccaataa tggcaatgat gacgtcttca     1260

tatacctttc aagttttcta cgcaataatt tggctctggg aggcagtttt gctgtaaaat     1320

taacagagac aagttggcat gagagtttat atgacattgc acaggattgt gcatggtgga     1380

caatgttttg tacagcagtg aatgcatctt cttcagaagc attcctgatt ggtgttaatt     1440

acttgggtgc aagtgcaaag gttaaagtta gtggaaaaac actgcacgca aattatatat     1500

tttggaggaa ttgtaattat ttacaaacct ctgcttatag tatatttgat gttgctaagt     1560

ttgatttgag attgaaagca acgccagttg ttaatcttaa gactgaacaa aagacagact     1620

tagtctttaa tttgataaag tgtggtaagt tactggtaag agatgttggt aacacctctt     1680

ttactagtga ctcttttgtg tgcactatgt agtgctgctt tgtatgactc gagttcttac     1740

gtgtactact accaaagtgc cttcagacca cctgatggtt ggcatttaca tgggggtgcg     1800

tatgcggttg ttaatatttc tagtgaatct aataatgcag gctcttcatc tgggtgtact     1860

gttggtatta ttcatggtgg tcgtgttgtt aatgcttctt ctatagctat gacggcaccg     1920

tcatcaggta tggcttggtc tagcagtcag ttttgtactg catactgtaa cttttcagat     1980

actacagtgt ttgttacaca ttgttataaa catggtgggt gtcctataac tggcatgctt     2040

caacagcatt ctatacgtgt ttctgctatg aaaaatggcc agcttttcta taatttaaca     2100

gttagtgtag ctaagtaccc tacttttaaa tcatttcagt gtgttaataa tttaacatcc     2160

gtatatttaa atggtgatct tgtttacacc tctaatgaga ccacagatgt tacatctgca     2220

ggtgtttatt ttaaagctgg tggacctata acttataaag ttatgagaga agttagagcc     2280

ctggcttatt ttgttaatgg tactgcacaa gatgttattt tgtgtgatgg gtcacctaga     2340

ggcttgttag catgccagta taatactggc aatttttcag atggctttta tccttttact     2400

aatagtagtt tagttaagca gaagtttatt gtctatcgtg aaaatagtgt taatactact     2460

tttacgttac acaatttcac ttttcataat gagactggcg ccaacccaaa tcctagtggt     2520

gtccagaata ttcaaactta ccaaacacaa acagctcaga gtggttatta taattttaat     2580

ttttcctttc tgagtagttt tgtttataag gagtctaatt ttatgtatgg atcttatcac     2640

ccaagttgta attttagact agaaactatt aataatggtt tgtggtttaa ttcactttca     2700

gttagtattg cttacggtcc tcttcaaggt ggttgcaagc aatctgtctt tagtggtaga     2760

gcaacctgtt gttatgctta ctcatatgga ggtcctttgc tgtgtaaagg tgtttattca     2820

ggtgagttag atcataattt tgaatgtgga ctgttagttt atgttactaa gagcggtggc     2880

tctcgtatac aaacagccac tgaaccgcca gttataactc aacacaatta taataatatt     2940

actttaaata cttgtgttga ttataatata tatggcagaa ctggccaggg ttttattact     3000

aatgtaaccg actcagctgt tagttataat tatctagcag acgcaggttt ggctatttta     3060

gatacatctg gttccataga catctttgtc gtacaaagtg aatatggtct taattattat     3120

aaggttaacc cttgcgaaga tgtcaaccag cagtttgtag tttctggtgg taaattagta     3180

ggtattctta cttcacgtaa tgagactggt tcccagcttc ttgagaatca gttttacatc     3240

aaaatcacta atggaacacg tcgttttaga cgttctatta ctgaaagtgt tgaaaattgc     3300

ccttatgtta gttatggtaa gttttgtata aaacctgatg gcagtattgc cacaatagta     3360

ccaaaacagt tagaacagtt tgtggcacct ttacttaatg ttactgaaaa tgtgctcata     3420

cctaacagtt ttaatttaac tgttacagat gagtacatac aaactcggat ggataaggtc     3480

caaattaatt gcctgcagta tatttgtggc aattctctgg agtgcagaaa tttgtttcaa     3540

caatatggtc ctgtttgcga caacatattg tctgtagtaa atagtgttgg tcaaaaagaa     3600

gatatggaac ttttgaattt ctattcttct actaagccgg ctggttttaa tacaccagtt     3660

cttagtaatg ttagcactgg tgagtttaat attactcttt ttttaacaac gcctagtagt     3720

cctagaaggc gttcttttat tgaagacctt ctatttacaa gtgttgaatc tgttggatta     3780

ccaacagatg acgcatacaa aaattgcact gcaggtcctt taggctttct gaaagacctt     3840

gcatgtgctc gtgaatataa tggtttgctt gtgttgcctc ctattataac agcagaaatg     3900

caaactttgt atacaagctc tctagtagct tctatggctt ttggtggtat tactgcagct     3960

ggtgctatac cttttgccac acaactgcag gctagaatta atcacttggg tattacccag     4020

tcacttcttt tgaagaatca agaaaaaatt gctgcttcct ttaataaggc catcggtcat     4080

atgcaggaag gttttagaag tacatcttta gcattacaac aaattcaaga tgttgttaat     4140

aagcagagtg ctattcttac tgagactatg gcatcactta ataaaaattt tggtgccatt     4200

tcttctgtga ttcaagaaat ctaccagcaa cttgacgcca tacaagcaaa tgctcaagtg     4260

gatcgtctta taactggtag attgtcatca ctttctgttt tagcatctgc taagcaggcg     4320

gagtatatta gagtgtcaca acagcgtgag ttagctactc agaagattaa tgagtgtgtt     4380

aagtcacagt ccattaggta ctccttttgt ggtaatggac gacatgtttt aaccataccg     4440

caaaatgcac ctaatggtat agtgtttata cacttttctt acactccaga tagttttgtt     4500

aatgttactg caatagtggg tttttgtgta aagccagcta atgctagtca gtatgcaata     4560

gtacccgcta atggtagggg tatttttata caagttaatg gtagttacta catcactgca     4620

cgagatatgt atatgccaag agctattact gcaggagata tagttacgct tacttcttgt     4680

caagcaaatt atgtaagtgt aaataagacc gtcattacta cattcgtaga caatgatgat     4740

tttgatttta atgacgaatt gtcaaaatgg tggaatgata ctaagcatga gctaccagac     4800

tttgacaaat tcaattacac agtacctata cttgacattg atagtgaaat tgatcgtatt     4860

caaggcgtta tacagggtct taatgactct ctaatagacc ttgaaaaact ttcaatactc     4920

aaaacttata ttaagtggcc ttggtatgtg tggctagcca tagcttttgc cactattatc     4980

ttcatcttaa tattaggatg ggttttcttc atgactgggt gttgtggttg ttgttgtgga     5040

tgctttggca ttatgcctct aatgagtaag tgtggtaaga aatcttctta ttacacgact     5100

tttgataacg atgtggtaac tgaacaatac agacctaaaa agtctgttta atgatccaaa     5160

gtcccactag tttcttaata gtattaattt tgctttggtg taaacttgta ctaagttgtt     5220

ttagagagtt tattattgcc cttcaacaac taacacaagt tttactccaa attatcgata     5280

gtaatttaca gtctagactg accctttggc acagtctaga ctaatgttaa acttagaagc     5340

aattattgaa accggtgatc aagtgattca aaaaatcagt ttcaatttac agcatatttc     5400

aagtgtatta aacacagaag tatttgaccc ctttgactat tgttattaca gaggaggtaa     5460

tttttgggaa atagagtcag ctgaagattg ttcaggtgat gatgaattta ttgaataagt     5520

cgctagagga gaatggaagt tttctaacgg cactttacat atttgtagga tttttagcat     5580

tttatcttct aggtagagca cttcaagcat ttgtacaggc tgctgatgct tgttgtttat     5640

tttggtacac gtggttagta attccaggag ttaagggtac agcctttgta tacaagtata     5700

catatggtag aaaacttaac aattcggaat tagaagcagt tgttgttaac gagtttccta     5760

agaacggttg gaataataaa aatccagcaa attttcaaga tgtccaacga aacaaattgt     5820

actcttgact ttgaacagtc agttgagctt tttaaagagt ataatttatt tataactgca     5880

ttcttgttgt tcttaaccat aatacttcag tatggttatg caacgcgtag taagtttatt     5940

tatatactta aaatgatagt gttatggtgc ttttggcccc ttaacattgc agtaggtgta     6000

atttcatgta tatacccacc aaacacagga ggtcttgtcg cagcgataat acttactgtg     6060

tttgcgtgtc tttcttttgt aggttattgg atccagagta ttagactctt taagcggtgt     6120

agatcttggt ggtcatttaa cccagaatct aacgccgtag gttcaatact cctaactaat     6180

ggtcaacaat gtaattttgc tatagagagt gtgccgatgg tgctttctcc tattataaag     6240

aatggtgttc tttattgtga gggtcagtgg cttgctaaat gtgaaccaga ccacttgcct     6300

aaagacatat ttgtatgcac accagataga cgtaatatct atcgtatggt gcagaaatac     6360

actggtgacc aaagcggaaa taagaaaagg tttgctacat ttgtctatgc aaagcagtca     6420

gtagacactg gcgagctaga aagtgtagca acaggtggaa gtagccttta cacataaatg     6480

tgtgtgtgta gagagtattt aaaattattc ttcaatagtg cctctatttt aagagcgcgg     6540

aagagtattt gttttgagga tattaatata aatcctcttt gttttgtact ctctttacaa     6600

gagttattat ttaagcaaca gtttttcctt tcctttgttt ggaagaaagt tgttgttaat     6660

ggtgtagaat tccaagtaga aaatggaaaa gtccactacg aaggaaaccc cattttccaa     6720

aaaggttgtt gtaggttgtg gtcccattat aagaaggatt aaatggatta aaccacctac     6780

actacttact tgtaataagg gcgtttggac ttacaagcgc ttaacaaata cagacgatga     6840

aatggctgac tagttttgga agagcagtta tttcttgtta taaagcccta ctattaactc     6900

agttaagagt attagatagg ttaattttag atcacggacc aaagcgagtc ttaacgtgtg     6960

gtaggcgagt gcttttatct caattagatt tagtttatag gttggcatat acgcccaccc     7020

aatcgctggt atgaataata gtaaagataa tccttttcgc ggagcaatag caagaaaagc     7080

gcgaatttat ctgagagaag gattagagtg tgtttacttt cttaacaaag caggacaagc     7140

agagccttgt cccgcgtgta cctccctagt atttcagggg aaaacttgtg aggaacacac     7200

agataataat aatcttttgt catggcgagc ggtaagacaa ctgggaagac agacgcccca     7260

gcgccagtca tcaaactagg agggccaaaa ccacctaaag ttggttcttc tggaaatgct     7320

agctggtttc aagcactaaa agccaagaag ttaaattcac ctcctcctaa gtttgaaggt     7380

agcggcgttc ctgataatga aaatcttaaa ttaagccagc aacatgggta ctggagacgt     7440

caagccaggt acaagccagg taaaggcgga agaaaatcag tcccagatgc ttggtacttc     7500

tattacactg gaacaggacc agccgctgac ctgaattggg gtgatagcca agatggtata     7560

gtgtgggttt ctgcaaaggg tgctgatact aaatctagat ctaaccaggg tacaagggat     7620

cctgataagt ttgaccaata cccgctacga ttctcagatg gaggacctga tggtaatttc     7680

cgttgggact tcattccaat aaatcgtggt aggagtggaa gatcaacagc ggcttcatca     7740

gcagcatcta gtagagcacc gtcgcgtgat ggctcgcgtg gacgtagaag cggagctgaa     7800

gatgatctta tagctcgtgc agcaaagatc attcaggatc agcagaagaa gggttctcgc     7860

attactaaag ctaaggccga tgaaatggct catcgccggt attgtaagcg tactatccca     7920

cctggttata aggttgatca agtatttggt ccccgtacta aaggtaagga gggaaatttt     7980

ggtgatgaca agatgaatga ggagggtatt aaggatgggc gcgttacagc aatgctcaac     8040

ctagtcccta gcagccatgc ttgtcttttt ggaagtagag tgacgcccaa acttcaacca     8100

gatgggctgc acttgagatt tgaatttact actgtggttt ctagggatga tccgcagttt     8160

gataattatg tgaaaatttg tgatcagtgt gtcgatggtg tagggactcg gccaaaagac     8220

gatgaaccga gaccaaagtc acgcccaaat tcaagacctg ctacaagaac aagttctcca     8280

gcgccaagac aacagcgtca aaagaaggag aagaagtcaa agaagcagga tgatgaagta     8340

gataaggcat tgacctcaga tgaggagagg aacaatgcac agctggaatt tgatgatgaa     8400

ccgaaagtga ttaactgggg ggattcagca cttggagaga atgagttgta aagctagatt     8460

tccaacttaa catcatggac gtgcgtatgc tgtttttccc tactatagac tttttagcat     8520

attatttttt gctatttgta tggtttatta caggtgaaga ttgtatgtat ttgttgtaca     8580

ctcgtatgtt ctatattatg ttttctgtag ttgttattag tgttgttctt gttcttactc     8640

tactgttctc ttttctttat tttagagtat caataagaat caaggaagat aggcatgtag     8700

tttgattacc tacatgtcta tcgccaggga aatgtctaat ctgtctactt agtagcctgg     8760

aaacgaacgg tagaccctta gattttaatt tagtttaatt tttagtttag tttaagttag     8820

tttagagtag gtataaagaa gccagtgccg gggccacgcg gagtacgatc gagggtacag     8880

cactaggacg cccactaggg gaagagctaa attttagttt aagttaagtt taattggcta     8940

agtatagtta aaatttatag gctagtatag agttagagca aaaaaaaaaa aaaaaaaaaa     9000

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     9060

aaaaaaaaaa aaaaaaaaag tttaaactta attaagaatt cccttggctc gagttcgaaa     9120

tcggatgccg ggaccgacga gtgcagaggc gtgcaagcga gcttggcgta atcatggtca     9180

tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat acgagccgga     9240

agcataaagt gtaaagcctg gggtgcctaa tgagtgagct aactcacatt aattgcgttg     9300

cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc     9360

caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc gctcactgac     9420

tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata     9480

cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa     9540

aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct     9600

gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa     9660

agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg     9720

cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca     9780

cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa     9840

ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg     9900

gtaagacacg acttatcgcc actggcagca gccactggta acaggattag cagagcgagg     9960

tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga    10020

acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc    10080

tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag    10140

attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac    10200

gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc    10260

ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag    10320

taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt    10380

ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag    10440

ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca    10500

gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact    10560

ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca    10620

gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg    10680

tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc    10740

atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg    10800

gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca    10860

tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt    10920

atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc    10980

agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc    11040

ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca    11100

tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa    11160

aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat    11220

tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa    11280

aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga cgtctaagaa    11340

accattatta tcatgacatt aacctataaa aataggcgta tcacgaggcc ctttcgtc      11398


<210>  10
<211>  11398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid Sequence

<400>  10
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt ggagatcggt acttcgcgaa      420

tgcgtcgaga tcggccgccc gggtaatacg actcactata gggacttaag atagatatta      480

atatatatct attgcactag ccttgcgcta gatttcaaac ttaacaaaac ggacttaaat      540

acctacagct ggtccccata ggtgttccat tgcagtgcac tttagtgccc tggatggcac      600

ctggccacct gtcaggtttt tgttgttaaa atatcattgt tgctggtatc actgcttgtt      660

ttgccgtgtc tcactttata catccgttgc ttgggctacc tagtatccag cgtcctacgg      720

gcgccgtggt cggttcgagt gcgaaggacc tctggttcat ctagcggtag gcgggtgtgt      780

ggaagtagcg cttcagacgt actggttctg ttgcgtgaaa cgcggggtca cctcccccca      840

catacctcta agggcttttg agcctagcgt tgggctacgt tctcgcacaa ggtcggctat      900

acgacgtttg tagggggtag tgccaaacaa cccctgaggt gacaggttct ggtggtgttt      960

cgaaaacaac aatgtgtgtg ccgcataata tgcgcgttat gcattttgga gcaggtagtg     1020

ataaaggagt ggcgcctggt agtactgttc ttaaacagtg gctccccgaa ggaacactcc     1080

ttgtcgataa tgatattgta gattatgttt ctgacgcaca cgtttctgtg ctttcagatt     1140

gcaataaata taagacagag cacaagtttg atcttgtgat atctgatatg tatacagaca     1200

atgattcaaa aagaaagcat gaaggcgtga tagccaataa tggcaatgat gacgtcttca     1260

tatacctttc aagttttcta cgcaataatt tggctctggg aggcagtttt gctgtaaaat     1320

taacagagac aagttggcat gagagtttat atgacattgc acaggattgt gcatggtgga     1380

caatgttttg tacagcagtg aatgcatctt cttcagaagc attcctgatt ggtgttaatt     1440

acttgggtgc aagtgcaaag gttaaagtta gtggaaaaac actgcacgca aattatatat     1500

tttggaggaa ttgtaattat ttacaaacct ctgcttatag tatatttgat gttgctaagt     1560

ttgatttgag attgaaagca acgccagttg ttaatcttaa gactgaacaa aagacagact     1620

tagtctttaa tttgataaag tgtggtaagt tactggtaag agatgttggt aacacctctt     1680

ttactagtga ctcttttgtg tgcactatgt agtgctgctt tgtatgactc gagttcttac     1740

gtgtactact accaaagtgc cttcagacca cctgatggtt ggcatttaca tgggggtgcg     1800

tatgcggttg ttaatatttc tagtgaatct aataatgcag gctcttcatc tgggtgtact     1860

gttggtatta ttcatggtgg tcgtgttgtt aatgcttctt ctatagctat gacggcaccg     1920

tcatcaggta tggcttggtc tagcagtcag ttttgtactg catactgtaa cttttcagat     1980

actacagtgt ttgttacaca ttgttataaa catggtgggt gtcctataac tggcatgctt     2040

caacagcatt ctatacgtgt ttctgctatg aaaaatggcc agcttttcta taatttaaca     2100

gttagtgtag ctaagtaccc tacttttaaa tcatttcagt gtgttaataa tttaacatcc     2160

gtatatttaa atggtgatct tgtttacacc tctaatgaga ccacagatgt tacatctgca     2220

ggtgtttatt ttaaagctgg tggacctata acttataaag ttatgagaga agttagagcc     2280

ctggcttatt ttgttaatgg tactgcacaa gatgttattt tgtgtgatgg gtcacctaga     2340

ggcttgttag catgccagta taatactggc aatttttcag atggctttta tccttttact     2400

aatagtagtt tagttaagca gaagtttatt gtctatcgtg aaaatagtgt taatactact     2460

tgtacgttac acaatttcac ttttcataat gagactggcg ccaacccaaa tcctagtggt     2520

gtccagaata ttcaaactta ccaaacacaa acagctcaga gtggttatta taattttaat     2580

ttttcctttc tgagtagttt tgtttataag gagtctaatt ttatgtatgg atcttatcac     2640

ccaagttgta attttagact agaaactatt aataatggtt tgtggtttaa ttcactttca     2700

gttagtattg cttacggtcc tcttcaaggt ggttgcaagc aatctgtctt tagtggtaga     2760

gcaacctgtt gttatgctta ctcatatgga ggtcctttgc tgtgtaaagg tgtttattca     2820

ggtgagttag atcataattt tgaatgtgga ctgttagttt atgttactaa gagcggtggc     2880

tctcgtatac aaacagccac tgaaccgcca gttataactc aacacaatta taataatatt     2940

actttaaata cttgtgttga ttataatata tatggcagaa ctggccaggg ttttattact     3000

aatgtaaccg actcagctgt tagttataat tatctagcag acgcaggttt ggctatttta     3060

gatacatctg gttccataga catctttgtc gtacaaagtg aatatggtct taattattat     3120

aaggttaacc cttgcgaaga tgtcaaccag cagtttgtag tttctggtgg taaattagta     3180

ggtattctta cttcacgtaa tgagactggt tcccagcttc ttgagaatca gttttacatc     3240

aaaatcacta atggaacacg tcgttttaga cgttctatta ctgaaagtgt tgaaaattgc     3300

ccttatgtta gttatggtaa gttttgtata aaacctgatg gcagtattgc cacaatagta     3360

ccaaaacagt tagaacagtt tgtggcacct ttacttaatg ttactgaaaa tgtgctcata     3420

cctaacagtt ttaatttaac tgttacagat gagtacatac aaactcggat ggataaggtc     3480

caaattaatt gcctgcagta tatttgtggc aattctctgg agtgcagaaa tttgtttcaa     3540

caatatggtc ctgtttgcga caacatattg tctgtagtaa atagtgttgg tcaaaaagaa     3600

gatatggaac ttttgaattt ctattcttct actaagccgg ctggttttaa tacaccagtt     3660

cttagtaatg ttagcactgg tgagtttaat attactcttt ttttaacaac gcctagtagt     3720

cctagaaggc gttcttttat tgaagacctt ctatttacaa gtgttgaatc tgttggatta     3780

ccaacagatg acgcatacaa aaattgcact gcaggtcctt taggctttct gaaagacctt     3840

gcatgtgctc gtgaatataa tggtttgctt gtgttgcctc ctattataac agcagaaatg     3900

caaactttgt atacaagctc tctagtagct tctatggctt ttggtggtat tactgcagct     3960

ggtgctatac cttttgccac acaactgcag gctagaatta atcacttggg tattacccag     4020

tcacttcttt tgaagaatca agaaaaaatt gctgcttcct ttaataaggc catcggtcat     4080

atgcaggaag gttttagaag tacatcttta gcattacaac aaattcaaga tgttgttaat     4140

aagcagagtg ctattcttac tgagactatg gcatcactta ataaaaattt tggtgccatt     4200

tcttctgtga ttcaagaaat ctaccagcaa cttgacgcca tacaagcaaa tgctcaagtg     4260

gatcgtctta taactggtag attgtcatca ctttctgttt tagcatctgc taagcaggcg     4320

gagtatatta gagtgtcaca acagcgtgag ttagctactc agaagattaa tgagtgtgtt     4380

aagtcacagt ccattaggta ctccttttgt ggtaatggac gacatgtttt aaccataccg     4440

caaaatgcac ctaatggtat agtgtttata cacttttctt acactccaga tagttttgtt     4500

aatgttactg caatagtggg tttttgtgta aagccagcta atgctagtca gtatgcaata     4560

gtacccgcta atggtagggg tatttttata caagttaatg gtagttacta catcactgca     4620

cgagatatgt atatgccaag agctattact gcaggagata tagttacgct tacttcttgt     4680

caagcaaatt atgtaagtgt aaataagacc gtcattacta cattcgtaga caatgatgat     4740

tttgatttta atgacgaatt gtcaaaatgg tggaatgata ctaagcatga gctaccagac     4800

tttgacaaat tcaattacac agtacctata cttgacattg atagtgaaat tgatcgtatt     4860

caaggcgtta tacagggtct taatgactct ctaatagacc ttgaaaaact ttcaatactc     4920

aaaacttata ttaagtggcc ttggtatgtg tggctagcca tagcttttgc cactattatc     4980

ttcatcttaa tattaggatg ggttttcttc atgactgggt gttgtggttg ttgttgtgga     5040

tgctttggca ttatgcctct aatgagtaag tgtggtaaga aatcttctta ttacacgact     5100

tttgataacg atgtggtaac tgaacaatac agacctaaaa agtctgttta atgatccaaa     5160

gtcccactag tttcttaata gtattaattt tgctttggtg taaacttgta ctaagttgtt     5220

ttagagagtt tattattgcc cttcaacaac taacacaagt tttactccaa attatcgata     5280

gtaatttaca gtctagactg accctttggc acagtctaga ctaatgttaa acttagaagc     5340

aattattgaa accggtgatc aagtgattca aaaaatcagt ttcaatttac agcatatttc     5400

aagtgtatta aacacagaag tatttgaccc ctttgactat tgttattaca gaggaggtaa     5460

tttttgggaa atagagtcag ctgaagattg ttcaggtgat gatgaattta ttgaataagt     5520

cgctagagga gaatggaagt tttctaacgg cactttacat atttgtagga tttttagcat     5580

tttatcttct aggtagagca cttcaagcat ttgtacaggc tgctgatgct tgttgtttat     5640

tttggtacac gtggttagta attccaggag ttaagggtac agcctttgta tacaagtata     5700

catatggtag aaaacttaac aattcggaat tagaagcagt tgttgttaac gagtttccta     5760

agaacggttg gaataataaa aatccagcaa attttcaaga tgtccaacga aacaaattgt     5820

actcttgact ttgaacagtc agttgagctt tttaaagagt ataatttatt tataactgca     5880

ttcttgttgt tcttaaccat aatacttcag tatggttatg caacgcgtag taagtttatt     5940

tatatactta aaatgatagt gttatggtgc ttttggcccc ttaacattgc agtaggtgta     6000

atttcatgta tatacccacc aaacacagga ggtcttgtcg cagcgataat acttactgtg     6060

tttgcgtgtc tttcttttgt aggttattgg atccagagta ttagactctt taagcggtgt     6120

agatcttggt ggtcatttaa cccagaatct aacgccgtag gttcaatact cctaactaat     6180

ggtcaacaat gtaattttgc tatagagagt gtgccgatgg tgctttctcc tattataaag     6240

aatggtgttc tttattgtga gggtcagtgg cttgctaaat gtgaaccaga ccacttgcct     6300

aaagacatat ttgtatgcac accagataga cgtaatatct atcgtatggt gcagaaatac     6360

actggtgacc aaagcggaaa taagaaaagg tttgctacat ttgtctatgc aaagcagtca     6420

gtagacactg gcgagctaga aagtgtagca acaggtggaa gtagccttta cacataaatg     6480

tgtgtgtgta gagagtattt aaaattattc ttcaatagtg cctctatttt aagagcgcgg     6540

aagagtattt gttttgagga tattaatata aatcctcttt gttttgtact ctctttacaa     6600

gagttattat ttaagcaaca gtttttcctt tcctttgttt ggaagaaagt tgttgttaat     6660

ggtgtagaat tccaagtaga aaatggaaaa gtccactacg aaggaaaccc cattttccaa     6720

aaaggttgtt gtaggttgtg gtcccattat aagaaggatt aaatggatta aaccacctac     6780

actacttact tgtaataagg gcgtttggac ttacaagcgc ttaacaaata cagacgatga     6840

aatggctgac tagttttgga agagcagtta tttcttgtta taaagcccta ctattaactc     6900

agttaagagt attagatagg ttaattttag atcacggacc aaagcgagtc ttaacgtgtg     6960

gtaggcgagt gcttttatct caattagatt tagtttatag gttggcatat acgcccaccc     7020

aatcgctggt atgaataata gtaaagataa tccttttcgc ggagcaatag caagaaaagc     7080

gcgaatttat ctgagagaag gattagagtg tgtttacttt cttaacaaag caggacaagc     7140

agagccttgt cccgcgtgta cctccctagt atttcagggg aaaacttgtg aggaacacac     7200

agataataat aatcttttgt catggcgagc ggtaagacaa ctgggaagac agacgcccca     7260

gcgccagtca tcaaactagg agggccaaaa ccacctaaag ttggttcttc tggaaatgct     7320

agctggtttc aagcactaaa agccaagaag ttaaattcac ctcctcctaa gtttgaaggt     7380

agcggcgttc ctgataatga aaatcttaaa ttaagccagc aacatgggta ctggagacgt     7440

caagccaggt acaagccagg taaaggcgga agaaaatcag tcccagatgc ttggtacttc     7500

tattacactg gaacaggacc agccgctgac ctgaattggg gtgatagcca agatggtata     7560

gtgtgggttt ctgcaaaggg tgctgatact aaatctagat ctaaccaggg tacaagggat     7620

cctgataagt ttgaccaata cccgctacga ttctcagatg gaggacctga tggtaatttc     7680

cgttgggact tcattccaat aaatcgtggt aggagtggaa gatcaacagc ggcttcatca     7740

gcagcatcta gtagagcacc gtcgcgtgat ggctcgcgtg gacgtagaag cggagctgaa     7800

gatgatctta tagctcgtgc agcaaagatc attcaggatc agcagaagaa gggttctcgc     7860

attactaaag ctaaggccga tgaaatggct catcgccggt attgtaagcg tactatccca     7920

cctggttata aggttgatca agtatttggt ccccgtacta aaggtaagga gggaaatttt     7980

ggtgatgaca agatgaatga ggagggtatt aaggatgggc gcgttacagc aatgctcaac     8040

ctagtcccta gcagccatgc ttgtcttttt ggaagtagag tgacgcccaa acttcaacca     8100

gatgggctgc acttgagatt tgaatttact actgtggttt ctagggatga tccgcagttt     8160

gataattatg tgaaaatttg tgatcagtgt gtcgatggtg tagggactcg gccaaaagac     8220

gatgaaccga gaccaaagtc acgcccaaat tcaagacctg ctacaagaac aagttctcca     8280

gcgccaagac aacagcgtca aaagaaggag aagaagtcaa agaagcagga tgatgaagta     8340

gataaggcat tgacctcaga tgaggagagg aacaatgcac agctggaatt tgatgatgaa     8400

ccgaaagtga ttaactgggg ggattcagca cttggagaga atgagttgta aagctagatt     8460

tccaacttaa catcatggac gtgcgtatgc tgtttttccc tactatagac tttttagcat     8520

attatttttt gctatttgta tggtttatta caggtgaaga ttgtatgtat ttgttgtaca     8580

ctcgtatgtt ctatattatg ttttctgtag ttgttattag tgttgttctt gttcttactc     8640

tactgttctc ttttctttat tttagagtat caataagaat caaggaagat aggcatgtag     8700

tttgattacc tacatgtcta tcgccaggga aatgtctaat ctgtctactt agtagcctgg     8760

aaacgaacgg tagaccctta gattttaatt tagtttaatt tttagtttag tttaagttag     8820

tttagagtag gtataaagaa gccagtgccg gggccacgcg gagtacgatc gagggtacag     8880

cactaggacg cccactaggg gaagagctaa attttagttt aagttaagtt taattggcta     8940

agtatagtta aaatttatag gctagtatag agttagagca aaaaaaaaaa aaaaaaaaaa     9000

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     9060

aaaaaaaaaa aaaaaaaaag tttaaactta attaagaatt cccttggctc gagttcgaaa     9120

tcggatgccg ggaccgacga gtgcagaggc gtgcaagcga gcttggcgta atcatggtca     9180

tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat acgagccgga     9240

agcataaagt gtaaagcctg gggtgcctaa tgagtgagct aactcacatt aattgcgttg     9300

cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc     9360

caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc gctcactgac     9420

tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata     9480

cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa     9540

aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct     9600

gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa     9660

agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg     9720

cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca     9780

cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa     9840

ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg     9900

gtaagacacg acttatcgcc actggcagca gccactggta acaggattag cagagcgagg     9960

tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga    10020

acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc    10080

tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag    10140

attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac    10200

gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc    10260

ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag    10320

taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt    10380

ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag    10440

ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca    10500

gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact    10560

ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca    10620

gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg    10680

tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc    10740

atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg    10800

gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca    10860

tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt    10920

atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc    10980

agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc    11040

ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca    11100

tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa    11160

aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat    11220

tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa    11280

aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga cgtctaagaa    11340

accattatta tcatgacatt aacctataaa aataggcgta tcacgaggcc ctttcgtc      11398


<210>  11
<211>  1155
<212>  PRT
<213>  Avian infectious bronchitis virus

<400>  11

Met Leu Asp Lys Pro Leu Leu Leu Val Thr Leu Trp Tyr Ala Leu Cys 
1               5                   10                  15      


Ser Ala Leu Leu Tyr Asp Asn Asn Thr Tyr Val Tyr Tyr Tyr Gln Ser 
            20                  25                  30          


Ala Phe Arg Pro Gly Pro Gly Trp His Leu Tyr Gly Gly Ala Tyr Ala 
        35                  40                  45              


Val Asp Arg Val Phe Asn Glu Thr Asn Asn Ala Gly Ser Ala Ser Asp 
    50                  55                  60                  


Cys Thr Ala Gly Thr Phe Tyr Glu Ser His Asn Ile Ser Ala Ser Ser 
65                  70                  75                  80  


Val Ala Met Thr Val Pro His Asn Gly Met Ser Trp Ser Ala Ser Gln 
                85                  90                  95      


Phe Cys Thr Ala His Cys Asn Phe Ser Asp Phe Thr Val Phe Val Thr 
            100                 105                 110         


His Cys Phe Lys Asn Gln Leu Gly Ser Cys Pro Leu Thr Gly Met Ile 
        115                 120                 125             


Pro Gln Asn His Ile Arg Ile Ser Ala Met Arg Asp Gly Val Leu Phe 
    130                 135                 140                 


Tyr Asn Leu Thr Val Ser Val Ser Lys Tyr Pro Arg Phe Lys Ser Leu 
145                 150                 155                 160 


Gln Cys Val Ser Asn Ser Thr Ser Val Tyr Val Asn Gly Asp Leu Val 
                165                 170                 175     


Phe Thr Ser Asn Glu Thr Ser Tyr Val Thr Gly Ala Gly Val Tyr Phe 
            180                 185                 190         


Lys Ser Gly Gly Pro Val Thr Tyr Lys Val Met Lys Glu Val Lys Ala 
        195                 200                 205             


Leu Ala Tyr Phe Ile Asn Gly Thr Ala Gln Glu Val Ile Leu Cys Asp 
    210                 215                 220                 


Asn Ser Pro Arg Gly Leu Leu Ala Cys Gln Tyr Asn Thr Gly Asn Phe 
225                 230                 235                 240 


Ser Asp Gly Phe Tyr Pro Phe Thr Asn His Ser Leu Val Lys Asp Arg 
                245                 250                 255     


Phe Ile Val Tyr Arg Glu Ser Ser Thr Asn Thr Thr Leu Lys Leu Thr 
            260                 265                 270         


Asn Phe Ser Phe Thr Asn Val Ser Asn Ala Ser Pro Asn Ser Gly Gly 
        275                 280                 285             


Val Asp Thr Phe Gln Leu Tyr Gln Thr Ser Thr Ala Gln Asp Gly Tyr 
    290                 295                 300                 


Tyr Asn Phe Asn Leu Ser Phe Leu Ser Ser Phe Val Tyr Lys Pro Ser 
305                 310                 315                 320 


Asp Phe Met Tyr Gly Ser Tyr His Pro His Cys Lys Phe Arg Pro Glu 
                325                 330                 335     


Asn Ile Asn Asn Gly Leu Trp Phe Asn Ser Leu Ser Val Ser Leu Thr 
            340                 345                 350         


Tyr Gly Pro Ile Gln Gly Gly Cys Lys Gln Ser Val Phe Ser Asn Arg 
        355                 360                 365             


Ala Thr Cys Cys Tyr Ala Tyr Ser Tyr Gln Gly Pro Ser Arg Cys Lys 
    370                 375                 380                 


Gly Val Tyr Arg Gly Glu Leu Thr Gln Tyr Phe Glu Cys Gly Leu Leu 
385                 390                 395                 400 


Val Tyr Val Thr Lys Ser Asp Gly Ser Arg Ile Gln Thr Arg Ser Glu 
                405                 410                 415     


Pro Leu Val Leu Thr Gln Tyr Asn Tyr Asn Asn Ile Thr Leu Asn Lys 
            420                 425                 430         


Cys Val Glu Tyr Asn Ile Tyr Gly Arg Val Gly Gln Gly Phe Ile Thr 
        435                 440                 445             


Asn Val Thr Glu Ala Thr Ala Asn Tyr Ser Tyr Leu Ala Asp Gly Gly 
    450                 455                 460                 


Leu Ala Ile Leu Asp Thr Ser Gly Ala Ile Asp Ile Phe Val Val Gln 
465                 470                 475                 480 


Gly Ala Tyr Gly Leu Asn Tyr Tyr Lys Val Asn Pro Cys Glu Asp Val 
                485                 490                 495     


Asn Gln Gln Phe Val Val Ser Gly Gly Asn Leu Val Gly Ile Leu Thr 
            500                 505                 510         


Ser His Asn Glu Thr Gly Ser Glu Ser Ile Glu Asn Gln Phe Tyr Ile 
        515                 520                 525             


Lys Leu Thr Asn Gly Thr Arg Arg Ser Arg Arg Ser Val Thr Gly Asn 
    530                 535                 540                 


Val Thr Asn Cys Pro Tyr Val Ser Tyr Gly Lys Phe Cys Ile Lys Pro 
545                 550                 555                 560 


Asp Gly Ser Leu Ser Ile Ile Val Pro Gln Glu Leu Glu Gln Phe Val 
                565                 570                 575     


Ala Pro Leu Phe Asn Val Thr Glu His Val Leu Ile Pro Asp Ser Phe 
            580                 585                 590         


Asn Leu Thr Val Thr Asp Glu Tyr Ile Gln Thr Arg Met Asp Lys Val 
        595                 600                 605             


Gln Ile Ile Cys Leu Gln Tyr Val Cys Gly Asn Ser Ile Glu Cys Arg 
    610                 615                 620                 


Lys Leu Phe Gln Gln Tyr Gly Pro Val Cys Asp Asn Ile Leu Ser Val 
625                 630                 635                 640 


Val Asn Gly Val Gly Gln Arg Glu Asp Met Glu Leu Leu Ser Phe Tyr 
                645                 650                 655     


Ser Ser Thr Lys Pro Ser Gly Tyr Asn Thr Pro Ile Phe Asn Asn Val 
            660                 665                 670         


Ser Thr Gly Asp Phe Asn Ile Ser Leu Leu Leu Thr Pro Pro Asn Ser 
        675                 680                 685             


Pro Thr Gly Arg Ser Phe Ile Glu Asp Leu Leu Phe Thr Ser Val Glu 
    690                 695                 700                 


Ser Val Gly Leu Pro Thr Asp Glu Glu Tyr Lys Lys Cys Thr Ala Gly 
705                 710                 715                 720 


Pro Leu Gly Phe Val Lys Asp Leu Val Cys Ala Arg Glu Tyr Asn Gly 
                725                 730                 735     


Leu Leu Val Leu Pro Pro Ile Ile Thr Ala Glu Met Gln Thr Met Tyr 
            740                 745                 750         


Thr Ser Ser Leu Val Ala Ser Met Ala Leu Gly Gly Ile Thr Ala Ala 
        755                 760                 765             


Gly Ala Ile Pro Phe Ala Thr Gln Leu Gln Ala Arg Ile Asn His Leu 
    770                 775                 780                 


Gly Ile Thr Asn Ser Leu Leu Leu Lys Asn Gln Glu Lys Ile Ala Ala 
785                 790                 795                 800 


Ser Phe Asn Lys Ala Ile Gly His Met Gln Glu Gly Phe Lys Ser Thr 
                805                 810                 815     


Ser Leu Ala Leu Gln Gln Ile Gln Asp Val Val Asn Lys Gln Ser Ser 
            820                 825                 830         


Ile Leu Thr Glu Thr Met Gln Ser Leu Asn Lys Asn Phe Gly Ala Ile 
        835                 840                 845             


Ser Ser Val Ile Gln Asp Ile Tyr Gln Gln Leu Asp Ala Ile Gln Ala 
    850                 855                 860                 


Asp Ala Gln Val Asp Arg Leu Ile Thr Gly Arg Leu Ser Ser Leu Ser 
865                 870                 875                 880 


Val Leu Ala Ser Ala Lys Gln Ala Glu Tyr His Arg Val Ser Gln Gln 
                885                 890                 895     


Arg Glu Leu Ala Thr Gln Lys Ile Asn Glu Cys Val Lys Ser Gln Ser 
            900                 905                 910         


Asn Arg Tyr Ser Phe Cys Gly Asn Gly Arg His Val Leu Thr Ile Pro 
        915                 920                 925             


Gln Asn Ala Pro Asn Gly Ile Val Phe Ile His Phe Thr Tyr Thr Pro 
    930                 935                 940                 


Glu Ser Phe Val Asn Val Thr Ala Ile Val Gly Phe Cys Val Asn Pro 
945                 950                 955                 960 


Ala Asn Ala Ser His Tyr Ala Ile Val Pro Val Asn Gly Arg Gly Val 
                965                 970                 975     


Phe Ile Glu Val Asn Gly Ser Tyr Tyr Ile Thr Ala Arg Asp Met Tyr 
            980                 985                 990         


Met Pro Arg Asp Ile Thr Ala Gly  Asp Ile Val Thr Leu  Thr Ser Cys 
        995                 1000                 1005             


Gln Ala  Asn Tyr Val Asn Val  Asn Lys Thr Val Ile  Asn Thr Phe 
    1010                 1015                 1020             


Val Glu  Asp Asp Asp Phe Asp  Phe Tyr Asp Glu Leu  Ser Lys Trp 
    1025                 1030                 1035             


Trp Asn  Asp Thr Lys His Glu  Leu Pro Asp Phe Asp  Glu Phe Asn 
    1040                 1045                 1050             


Tyr Thr  Val Pro Val Leu Asn  Ile Ser Asn Glu Ile  Asp Arg Ile 
    1055                 1060                 1065             


Gln Gln  Val Ile Gln Gly Leu  Asn Asp Ser Leu Ile  Asp Leu Glu 
    1070                 1075                 1080             


Thr Leu  Ser Ile Leu Lys Thr  Tyr Ile Lys Trp Pro  Trp Tyr Val 
    1085                 1090                 1095             


Trp Leu  Ala Ile Ala Phe Leu  Thr Ile Ile Phe Ile  Leu Val Leu 
    1100                 1105                 1110             


Cys Trp  Ile Phe Phe Met Thr  Gly Cys Cys Gly Cys  Cys Cys Gly 
    1115                 1120                 1125             


Cys Phe  Gly Ile Ile Pro Leu  Met Ser Lys Cys Gly  Lys Lys Ser 
    1130                 1135                 1140             


Ser Tyr  Tyr Thr Thr Phe Asp  Asn Asp Val Val Thr  
    1145                 1150                 1155 


<210>  12
<211>  11860
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid Sequence

<400>  12
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt ggagatcggt acttcgcgaa      420

tgcgtcgaga tgagctctaa tacgactcac tatagggact taagtgtgat ataaatatat      480

atcatacata ctagccttgt gctagatttc caacttaaca aaacggactt aaatacctac      540

agttggtccc tataggtgtt ccattgcagt gcactttagt gccctggatg gcacctggcc      600

acctgtcagg tttttgttat taaaataata ttgttgctgg tatcactgct tgttttgccg      660

tgtctcactt tatacatccg ttgcttgggc tacctagtat ccagcgtcct actggcgttg      720

tggtcggttc gagtgcgaag aacctctggt tcatctagcg gtacgcgggt gtgtggaagt      780

agcgcttcag acgtaccggt tctgttgcgt gaaatacggg gtcacctccc cccacatacc      840

tctaagggct tttgagccta gcgttgggct acgttctcgc acaaggtcgg ctatacggcg      900

tttgtagggg gtagtgccaa acaacccctg aggtgacagg ttctggtggt gtttcgaaaa      960

caacaatgtg tgtgccgcat aatatgcgag taatgcattt tggagcagga agtgacaaag     1020

gagtggcccc aggtagcgct gttcttaggc agtggcttcc cgaaggtaca ctccttgtcg     1080

ataatgatat tgtagattat gtatctgatg cacatgtctc tgtgctttca gattgcaata     1140

aatgtaaaac agagcacaag tttgatcttg tgatatctga tatgtataca gataatgatt     1200

caaagagaaa gcatgaaggc gttgtagcca ataacggcaa tgatgacgtc ttcatatacc     1260

tttcaaactt tcttcgtaac aatttagctc tgggaggcag ttttgccgta aaagtaacag     1320

agacaagttg gcatgagagt ttatatgaca ttgcacagga ttgtgcatgg tggacaatgt     1380

tttgtacagc agtgaatgct tcttcgtcag aagcattctt gattggtgtt aattatttgg     1440

gtgcaagtga aaaggttaga gttagtggta aaaccctgca cgcaaattat atattttgga     1500

ggaattgtaa ttatttacaa acttcagcct atagtatatt tgacgttgct aagtttgatt     1560

tgaaattaaa agcaacgcca gttgtgaatt tgaaaactga acaaaagaca gacttagtct     1620

ttaatttaat taagtgtggt aagttactgg taagagatgt tggacaaacc gcttttacta     1680

gtgactcttt ggtatgcact atgtagtgct ttgctctatg ataataatta tattggtgat     1740

tttagatgta tccagcttgt gaactcaaac ggtgctaatg ttagtgctcc aagcattagc     1800

actgagaccg ttgaagtttc acaaggcctg gggacatatt atgtgttaga tcgagtttat     1860

ttaaatgcca cattattgct tactggttac tacccggtcg atggttctaa gtttagaaac     1920

ctcgctctta cgggaactaa ctcagttagc ttgtcgtggt ttcaaccacc ctatttaagt     1980

cagtttaatg atggcatatt tgcgaaggtg cagaacctta agacaagtac gccatcaggt     2040

gcaactgcat attttcctac tatagttata ggtagtttgt ttggctatac ttcctatacc     2100

gttgtaatag agccatataa tggtgttata atggcctcag tgtgccagta taccatttgt     2160

cagttacctt acactgattg taagcctaac actaatggta ataagcttat agggttttgg     2220

cacacggatg taaaaccccc aatttgtgtg ttaaagcgaa atttcacgct taatgttaat     2280

gctgatgcat tttattttca tttttaccaa catggtggta ctttttatgc gtactatgcg     2340

gataaaccct ccgctactac gtttttgttt agtgtatata ttggcgatat tttaacacag     2400

tattatgtgt tacctttcat ctgcaaccca acagctggta gcacttttgc tccgcgctat     2460

tgggttacac ctttggttaa gcgccaatat ttgtttaatt tcaaccagaa gggtgtcatt     2520

actagtgctg ttgattgtgc tagtagttat accagtgaaa taaaatgtaa gacccagagc     2580

atgttaccta gcactggtgt ctatgagtta tccggttata cggtccaacc agttggagtt     2640

gtataccggc gtgttgctaa cctcccagct tgtaatatag aggagtggct tactgctagg     2700

tcagtcccct cccctctcaa ctgggagcgt aagacttttc agaattgtaa ttttaattta     2760

agcagcctgt tacgttatgt tcaggctgag agtttgtttt gtaataatat cgatgcttcc     2820

aaagtgtatg gcaggtgctt tggtagtatt tcagttgata agtttgctgt accccgaagt     2880

aggcaagttg atttacagct tggtaactct ggatttctgc agactgctaa ttataagatt     2940

gatacagctg ccacttcgtg tcagctgcat tacaccttgc ctaagaataa tgtcaccata     3000

aacaaccata acccctcgtc ttggaatagg aggtatggct ttaatgatgc tggcgtcttt     3060

ggcaaaaacc aacatgacgt tgtttacgct cagcaatgtt ttactgtaag atctagttat     3120

tgcccgtgtg ctcaaccgga catagttagc ccttgcacta ctcagactaa gcctaagtct     3180

gcttttgtta atgtgggtga ccattgtgaa ggcttaggtg ttttagaaga taattgtggc     3240

aatgctgatc cacataaggg ttgtatctgt gccaacaatt catttattgg atggtcacat     3300

gatacctgcc ttgttaatga tcgctgccaa atttttgcta atatattgtt aaatggcatt     3360

aatagtggta ccacatgttc cacagatttg cagttgccta atactgaagt ggttactggc     3420

atttgtgtca aatatgacct ctacggtatt actggacaag gtgtttttaa agaggttaag     3480

gctgactatt ataatagctg gcaaaccctt ctgtatgatg ttaatggtaa tttgaatggt     3540

tttcgtgatc ttaccactaa caagacttat acgataagga gctgttatag tggccgtgtt     3600

tctgctgcat ttcataaaga tgcacccgaa ccggctctgc tctatcgtaa tataaattgt     3660

agctatgttt ttagcaataa tatttcccgt gaggagaacc cacttaatta ctttgatagt     3720

tatttgggtt gtgttgttaa tgctgataac cgcacggatg aggcgcttcc taattgtgat     3780

ctccgtatgg gtgctggctt atgcgttgat tattcaaaat cacgcagggc tcaccgatca     3840

gtttctactg gctatcggtt aactacattt gagccataca ctccgatgtt agttaatgat     3900

agtgtccaat ccgttgatgg attatatgag atgcaaatac caaccaattt tactattggg     3960

caccatgagg agttcattca aactagatct ccaaaggtga ctatagattg tgctgcattt     4020

gtctgtggtg ataacactgc atgcaggcag cagttggttg agtatggctc tttctgtgtt     4080

aatgttaatg ccattcttaa tgaggttaat aacctcttgg ataatatgca actacaagtt     4140

gctagtgcat taatgcaggg tgttactata agttcgagac tgccagacgg catctcaggc     4200

cctatagatg acattaattt tagtcctcta cttggatgca taggttcaac atgtgctgaa     4260

gacggcaatg gacctagtgc aatccgaggg cgttctgcta tagaggattt gttatttgac     4320

aaggtcaaat tatctgatgt tggctttgtc gaggcttata ataattgcac cggtggtcaa     4380

gaagttcgtg acctcctttg tgtacaatct tttaatggca tcaaagtatt acctcctgtg     4440

ttgtcagaga gtcagatctc tggctacaca accggtgcta ctgcggcagc tatgttccca     4500

ccgtggtcag cagctgccgg tgtgccattt agtttaagtg ttcaatatag aattaatggt     4560

ttaggtgtca ctatgaatgt gcttagtgag aaccaaaaga tgattgctag tgcttttaac     4620

aatgcgctgg gtgctatcca ggatgggttt gatgcaacca attctgcttt aggtaagatc     4680

cagtccgttg ttaatgcaaa tgctgaagca ctcaataact tactaaatca actttctaac     4740

aggtttggtg ctattagtgc ttctttacaa gaaattctaa ctcggcttga ggctgtagaa     4800

gcaaaagccc agatagatcg tcttattaat ggcaggttaa ctgcacttaa tgcgtatata     4860

tccaagcaac ttagtgatag tacgcttatt aaagttagtg ctgctcaggc catagaaaag     4920

gtcaatgagt gcgttaagag ccaaaccacg cgtattaatt tctgtggcaa tggtaatcat     4980

atattatctc ttgtccagaa tgcgccttat ggcttatatt ttatacactt cagctatgtg     5040

ccaatatcct ttacaaccgc aaatgtgagt cctggacttt gcatttctgg tgatagagga     5100

ttagcaccta aagctggata ttttgttcaa gatgatggag aatggaagtt cacaggcagt     5160

tcatattact accctgaacc cattacagat aaaaacagtg tcattatgag tagttgcgca     5220

gtaaactaca caaaggcacc tgaagttttc ttgaacactt caatacctaa tccacccgac     5280

tttaaggagg agttagataa atggtttaag aatcagacgt ctattgcgcc tgatttatct     5340

ctcgatttcg agaagttaaa tgttactttg ctggacctga cgtatgagat gaacaggatt     5400

caggatgcaa ttaagaagtt aaatgagagc tacatcaacc tcaaggaagt tggcacatat     5460

gaaatgtatg tgaaatggcc ttggtatgtg tggcttgcca ttgcattcct taccattatt     5520

tttattctgg tactttgttg gatatttttc atgaccggtt gttgcggttg ttgttgtgga     5580

tgctttggta tcataccgtt aatgagtaag tgtggtaaga aatcttctta ctacacgact     5640

tttgataatg atgtggtaac ttaacaatac agacctaaaa agtctgttta atgattaaaa     5700

gtcccacatc ttttctaata ttattaattc ttctttggtg taaacttgca ttaagttgtt     5760

ttaaagagtg tgttataaca ctccagcaac tagtacaaat tttactccaa attattaata     5820

gtaacttaca atctagactt ctgctttggc acagtctaga ctaatgttag attttgaagc     5880

aattattgaa actggtcagc aaataactca acaaattagt ttctatttac agcatatttc     5940

aagggtgcta agtactgaat tatttgaccc ctttgaagtt tgtgtttaca gaggaggtaa     6000

ttgttgggag ttagagtcag ctgacgagtt ttcaggtgat gacgaatata ttgagtagat     6060

cgctcgagga gaacggaagt tttctaacag cggtttacgt gtttttagga tttttagcac     6120

tttatctact aggtagagcg cttcaagctt ttgtacaagc ggctgacgct tgttgtcttt     6180

tttggtatac atgggtagta gttcctggag ccaagggcac agcctttgtt tataatcata     6240

catatggtaa aaaacttaac aaaccggagt tagaaacggt tattgttaac gaatttccaa     6300

aaaacggttg gaaatatgga taataccatc aattgtactc ttggtactga acaagcagtt     6360

cagcttttta aggaatataa tctgtttgta actgcattcc tgttgttttt aaccatacta     6420

cttcagtatg gatacgcaac taggagcaag gttatttaca tactgaaaat gatagtgtta     6480

tggtgctttt ggccccttaa cattgcagta ggtgtaatct catgtatata cccaccaaac     6540

acaggaggtc ttgtcgcagc gataattctt acagtgtttg cgtgtctttc ttttataggt     6600

tattggatcc agagtattag actttttaag cggtgcaggt catggtggtc atttaacccc     6660

gaatctaatg ccgtaggttc aatactccta actaatggtc aacaatgtaa ttttgctata     6720

gagagtgtgc cgatggtgct ttctcctatt ataaagaatg gtgctcttta ttgcgagggt     6780

cagtggcttg ctaaatgtga accagaccac ttgcctagag atatatttgt atgcacaccg     6840

gatagacgta atatctatcg tatggtgcaa aaatatactg gtgaccaaag cggaagtaag     6900

aaaaggtttg ccacatttgt ctatgcaaag cagtcagtag atactggcga gctagaaagt     6960

gtgtcagcag taggaggtag tctttacaca taaatgtgtg tgtgtagaga gtatttaaaa     7020

ttattctttg acagtgcctc cgttttaaga gcgcggaaga gtattatttt tgaggatatt     7080

aatataaatc ctctttgttt catactctcc tttcaggagt tattatttaa aaaacagttt     7140

ttccactctt ttgtgccaaa aacaattgtt gttaatggtg taacctttca ggtagacaat     7200

ggaaaagtct actacgaagg aagaccaatt ttccaaaaag gttgttgtag tttgtggtcc     7260

aattataaga aagattagaa taattaaacc acctacaaca cttattttta caaatggcgt     7320

tttaggttac aaacgcttaa caaatacgga tgatgaaatg gctgactagt tttggaagag     7380

ctttcatctc ctgttataaa tccctattac taactcaatt aagagtatta gataggttaa     7440

ttttagatca cggacccaag cgcacattaa cgtgtgctag gcgagtgctt ttagttcaat     7500

tagatttagt ttataggttg gcttatacgc ccacccaatc gctggtatga ataatagtaa     7560

agataatcct tttcgcggag caatagcaag aaaagcgcga atttatctga gaggaggatt     7620

agattgtgtt tactttctta acaaagcagg acaagcagag ccttgtcccg cgtgtacctc     7680

cctagtattc caagggaaaa cttgtgagga acactattat aataacaatc ttttgtcatg     7740

gcaagcggta aggcaactgg aaagacagac gccccagcgc cagtcatcaa actaggagga     7800

ccaaagccac ctaaagttgg ttcttctgga aatgcatcat ggtttcaacc gataaaggcc     7860

aagaagctaa attcacctgt gcctaaattt gacggtagtg gtgttcctga aaatgaaaat     7920

ctcaagtcaa gccagcaaca tggatactgg agacgccaac acaggtttaa gcctggcaaa     7980

ggtggaagaa aaccagtccc tgatgcttgg tacttttact acactggaac aggaccggcc     8040

gccgacctga attggggtga aactcaagat ggtatagtgt gggttgctgc aaagggtgct     8100

gatactaaat ctagatcaaa ccagggtaca agggatcctg ataagtttga ccaataccca     8160

ctacgattct cagatggagg accggatggt aatttccgtt gggacttcat accaataaat     8220

cgtggtagga gtgggagatc aacagcagct tcatcagcag catctagtag agcaccatct     8280

cgtgaggggt cacgtggacg tagaagcgga gttgaagatg atcttatagc tcgcgcagca     8340

aagattatac aggaccagca aaagaagggt gcgcgcatta ccaaggctaa ggctgatgaa     8400

atggctcatc gccgctattg caagcgcact atcccacctg gttataaggt tgagcaagta     8460

tttggtcccc gtactaaagg taaggaagga aattttggtg atgacaagat gaatgaggaa     8520

ggtgttaagg atgggcgtgt tacggcaatg ctcaacctag tccctagcag tcatgcttgt     8580

ctttttggaa gtagggtgac gcccaaactg cagccagatg gtcttcacct gagatttgaa     8640

tttactactg tggtgtcacg tgatgatccg cagtttgata attatgtgaa aatttgtgat     8700

cagtgtgtcg atggtgtagg gacgcgtcca aaggacgatg aatcgagacc aaagtcacgc     8760

ccaaattcaa gacctgcaac tagaggaaat tctccagcgc cgagacaaca gcgcccaaag     8820

aaggagaaaa agcccaagaa gcaggatgat gaagtagata aggcattgac ctcagatgag     8880

gagaggaaca atgcacagct ggaatttgat gatgaaccca aggtgattaa ctggggggac     8940

tctgcactag gtgaaaatga actttgatta acataatgga cttgctgcat ttgctgtcac     9000

attttgttaa atattatttt tgtgttttac tatcaattat tacaggtatt gattgtgatt     9060

atgttcaata cttaagcttc ttctggttgc tttttgcttg ttgtattgtt gctgtgcttt     9120

ttattattgt gattctcatt agtttgcttt atcgtagaaa ttcaatagta agagttaagg     9180

aagataggca tgtagcttag cacctacatg tctatcgcca gggaaatgtc taatctgtct     9240

acttagtagc ctggaaacga acggtagacc cttagatttt aatttagttt aatttttagt     9300

ttagtttaag ttagtttaga gtaggtataa agatgccagt gccggggcca cgcgtagtac     9360

gaccgagggt acagcactag gacgcccact aggggaagag ctaaatttta gtttaagtta     9420

agtttaattg gctaaatata gttaaaattt ataggctagt atagagttag agcaaaaaaa     9480

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     9540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaagcggccg catcggatgc cgggaccgac     9600

gagtgcagag gcgtgcaagc gagcttggcg taatcatggt catagctgtt tcctgtgtga     9660

aattgttatc cgctcacaat tccacacaac atacgagccg gaagcataaa gtgtaaagcc     9720

tggggtgcct aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc     9780

cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc     9840

ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt     9900

cggctgcggc gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca     9960

ggggataacg caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa    10020

aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat    10080

cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc    10140

cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc    10200

gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt    10260

tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac    10320

cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg    10380

ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca    10440

gagttcttga agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc    10500

gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa    10560

accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa    10620

ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac    10680

tcacgttaag ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta    10740

aattaaaaat gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt    10800

taccaatgct taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata    10860

gttgcctgac tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc    10920

agtgctgcaa tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac    10980

cagccagccg gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag    11040

tctattaatt gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac    11100

gttgttgcca ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc    11160

agctccggtt cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg    11220

gttagctcct tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc    11280

atggttatgg cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct    11340

gtgactggtg agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc    11400

tcttgcccgg cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc    11460

atcattggaa aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc    11520

agttcgatgt aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc    11580

gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca    11640

cggaaatgtt gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt    11700

tattgtctca tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt    11760

ccgcgcacat ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca    11820

ttaacctata aaaataggcg tatcacgagg ccctttcgtc                          11860


<210>  13
<211>  6905
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid Sequence

<400>  13
ttaattaagt gtggtaagtt actggtaaga gatgttggac aaaccgcttt tactagtgac       60

tctttggtat gcactatgta gtgctttgct ctatgataat aatacttacg tttactacta      120

ccaaagtgcc tttaggcctg gtccaggttg gcacctatat gggggtgctt atgcagtaga      180

tagggttttt aatgaaacca acaatgcagg cagtgcatct gattgcactg ctggtacttt      240

ttatgaaagc cataatattt ctgcttcttc tgtagccatg acagtaccac ataatggtat      300

gtcttggtca gcttcacaat tttgtacagc tcattgtaac ttctcagact ttacagtgtt      360

cgttacgcat tgttttaaaa atcaactcgg tagttgtccc ttgacaggta tgattcctca      420

gaatcatatt cgtatttctg ctatgagaga tggagttttg ttttataact taacagttag      480

cgtatctaaa taccctagat ttaaatcgct tcaatgtgtt agcaattcta catctgtcta      540

tgtaaatggt gaccttgttt tcacttctaa tgaaacttct tacgttacgg gtgcaggcgt      600

ttattttaaa agtggtgggc ctgtaactta taaagttatg aaagaagtta aagccctagc      660

ctactttatt aatggtaccg cacaagaggt tattttatgt gataactcac ctagaggttt      720

gcttgcatgt cagtataaca ctggtaattt ttcagatgga ttctaccctt ttactaatca      780

ttctttagtt aaggataggt ttattgtata tcgagaaagt agcactaaca ctactttaaa      840

gttaactaat ttcagtttta ctaatgtaag taatgcttct cctaattcag gtggcgttga      900

tactttccaa ttatatcaaa caagtactgc tcaggatggt tattataatt ttaatttatc      960

atttctgagt agttttgtgt ataaaccatc tgattttatg tatgggtcat accacccaca     1020

ttgtaagttt agaccagaga atattaataa tggcttatgg tttaattcat tatctgtgtc     1080

acttacttac ggacccattc aaggtggttg taagcaatct gtttttagta atagagcaac     1140

ttgttgctat gcttattctt atcaagggcc tagtagatgt aagggtgttt atagagggga     1200

gctaacgcaa tactttgaat gtggacttct agtttacgta actaagagtg atggctctcg     1260

tatacaaact agaagtgaac cactggtgtt aactcaatat aattataaca acattacttt     1320

aaataagtgt gttgagtata atatatatgg tagggttggt caaggtttta ttactaatgt     1380

aactgaagca actgctaatt atagttatct agcagatggt ggtttagcta ttttagatac     1440

ctcaggagcc atagacatat ttgttgttca aggtgcatat ggtcttaatt attataaggt     1500

taatccctgt gaagatgtta accaacagtt tgtagtgtct ggtggcaact tagttggcat     1560

tcttacatct cataatgaaa caggttctga atctattgag aaccagtttt acatcaaact     1620

cactaacgga acacgtcgct ctagacgttc tgttactggg aatgttacaa attgccctta     1680

tgttagttat ggcaagtttt gtataaaacc agatggttct ttatctataa tagtaccaca     1740

agaattagaa cagtttgtgg cgcctttatt caatgttact gagcatgtgc tcatacctga     1800

tagttttaat ttaactgtca cagatgagta catacaaact cgtatggata aggttcaaat     1860

tatttgcctt cagtatgttt gtggtaattc tattgaatgc agaaagttgt ttcagcagta     1920

tggacctgtt tgtgataata tattgtctgt tgtaaatggt gtaggtcaaa gagaggatat     1980

ggaactttta agtttctatt cttctactaa acctagtggt tacaatacac caatttttaa     2040

taatgttagc actggtgact ttaatatttc gctcctacta acaccaccta atagtcctac     2100

tgggcgctct tttattgaag atcttctctt tacaagtgta gaatctgttg gattaccaac     2160

tgatgaagag tataaaaagt gtacagcagg acctttaggt tttgttaaag accttgtttg     2220

tgctagagag tataatggtt tgctcgttct gcctcctatt attactgcgg aaatgcaaac     2280

catgtatact agttctttag tagcctctat ggctttaggt ggcattactg cagctggtgc     2340

tatacctttt gctacacaac tgcaggccag aattaaccat ttgggtatta ctaattctct     2400

tttgttgaaa aaccaagaaa aaattgctgc ttcctttaat aaggccatcg gtcatatgca     2460

ggaagggttt aaaagtactt ctctagcatt acaacagatt caagatgttg ttaataaaca     2520

gagttctatt cttacagaga ctatgcaatc acttaataaa aattttggtg ctatttcctc     2580

tgtaattcaa gacatttacc agcaactaga tgctattcag gcagatgctc aggttgatcg     2640

tcttattaca ggtagactct cttcactatc tgttttagct tctgctaaac aggcagagta     2700

tcatagagtg tcacaacagc gtgagttggc cactcagaaa attaatgagt gtgttaagtc     2760

tcagtctaat aggtattcat tttgtggtaa tggtagacat gttctaacca taccacagaa     2820

tgcacccaat ggcatagtgt ttatacactt tacatacact ccagagagtt ttgttaatgt     2880

tacggcaata gtagggtttt gcgtaaaccc agctaatgct agtcattatg caatagtgcc     2940

tgttaatggc aggggtgttt ttatagaagt taatggtagt tactatatca ctgctcgtga     3000

tatgtatatg ccaagagata ttactgcagg agacatagtc actttgactt cttgtcaagc     3060

aaactatgtt aatgtaaata aaaccgtcat taacactttt gtggaagatg acgattttga     3120

tttttatgat gaattgtcaa aatggtggaa tgatactaag catgagctac cagattttga     3180

tgaattcaat tataccgttc cagttttaaa tattagtaat gaaattgaca gaattcaaca     3240

ggttattcag ggattaaatg attccctaat agaccttgaa acactctcaa ttctcaaaac     3300

ttatattaaa tggccttggt atgtgtggct tgccattgca ttccttacca ttatttttat     3360

tctggtactt tgttggatat ttttcatgac cggttgttgc ggttgttgtt gtggatgctt     3420

tggtatcata ccgttaatga gtaagtgtgg taagaaatct tcttactaca cgacttttga     3480

taatgatgtg gtaacttaac aatacagacc taaaaagtct gtttaatgat taaaagtccc     3540

acatcttttc taatattatt aattcttctt tggtgtaaac ttgcattaag ttgttttaaa     3600

gagtgtgtta taacactcca gcaactagta caaattttac tccaaattat taatagtaac     3660

ttacaatcta gacttctgct ttggcacagt ctagactaat gttagatttt gaagcaatta     3720

ttgaaactgg tcagcaaata actcaacaaa ttagtttcta tttacagcat atttcaaggg     3780

tgctaagtac tgaattattt gacccctttg aagtttgtgt ttacagagga ggtaattgtt     3840

gggagttaga gtcagctgac gagttttcag gtgatgacga atatattgag tagatcgctc     3900

gagaatcact agtgcggccg cctgcaggtc gaccatatgg gagagctccc aacgcgttgg     3960

atgcatagct tgagtattct atagtgtcac ctaaatagct tggcgtaatc atggtcatag     4020

ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc     4080

ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc     4140

tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa     4200

cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg     4260

ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg     4320

ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag     4380

gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac     4440

gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga     4500

taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt     4560

accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc     4620

tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc     4680

cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta     4740

agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat     4800

gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac tagaagaaca     4860

gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct     4920

tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt     4980

acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct     5040

cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc     5100

acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa     5160

acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta     5220

tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc     5280

ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat     5340

ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta     5400

tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt     5460

aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt     5520

ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg     5580

ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc     5640

gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc     5700

gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg     5760

cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga     5820

actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta     5880

ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct     5940

tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag     6000

ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca atattattga     6060

agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat     6120

aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctgatgc ggtgtgaaat     6180

accgcacaga tgcgtaagga gaaaataccg catcaggaaa ttgtaagcgt taatattttg     6240

ttaaaattcg cgttaaattt ttgttaaatc agctcatttt ttaaccaata ggccgaaatc     6300

ggcaaaatcc cttataaatc aaaagaatag accgagatag ggttgagtgt tgttccagtt     6360

tggaacaaga gtccactatt aaagaacgtg gactccaacg tcaaagggcg aaaaaccgtc     6420

tatcagggcg atggcccact acgtgaacca tcaccctaat caagtttttt ggggtcgagg     6480

tgccgtaaag cactaaatcg gaaccctaaa gggagccccc gatttagagc ttgacgggga     6540

aagccggcga acgtggcgag aaaggaaggg aagaaagcga aaggagcggg cgctagggcg     6600

ctggcaagtg tagcggtcac gctgcgcgta accaccacac ccgccgcgct taatgcgccg     6660

ctacagggcg cgtccattcg ccattcaggc tgcgcaactg ttgggaaggg cgatcggtgc     6720

gggcctcttc gctattacgc cagctggcga aagggggatg tgctgcaagg cgattaagtt     6780

gggtaacgcc agggttttcc cagtcacgac gttgtaaaac gacggccagt gaattgtaat     6840

acgactcact atagggcgaa ttgggcccga cgtcgcatgc tcccggccgc catggccgcg     6900

ggatt                                                                 6905


<210>  14
<211>  11320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid Sequence

<400>  14
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt ggagatcggt acttcgcgaa      420

tgcgtcgaga tgagctctaa tacgactcac tatagggact taagtgtgat ataaatatat      480

atcatacata ctagccttgt gctagatttc caacttaaca aaacggactt aaatacctac      540

agttggtccc tataggtgtt ccattgcagt gcactttagt gccctggatg gcacctggcc      600

acctgtcagg tttttgttat taaaataata ttgttgctgg tatcactgct tgttttgccg      660

tgtctcactt tatacatccg ttgcttgggc tacctagtat ccagcgtcct actggcgttg      720

tggtcggttc gagtgcgaag aacctctggt tcatctagcg gtacgcgggt gtgtggaagt      780

agcgcttcag acgtaccggt tctgttgcgt gaaatacggg gtcacctccc cccacatacc      840

tctaagggct tttgagccta gcgttgggct acgttctcgc acaaggtcgg ctatacggcg      900

tttgtagggg gtagtgccaa acaacccctg aggtgacagg ttctggtggt gtttcgaaaa      960

caacaatgtg tgtgccgcat aatatgcgag taatgcattt tggagcagga agtgacaaag     1020

gagtggcccc aggtagcgct gttcttaggc agtggcttcc cgaaggtaca ctccttgtcg     1080

ataatgatat tgtagattat gtatctgatg cacatgtctc tgtgctttca gattgcaata     1140

aatgtaaaac agagcacaag tttgatcttg tgatatctga tatgtataca gataatgatt     1200

caaagagaaa gcatgaaggc gttgtagcca ataacggcaa tgatgacgtc ttcatatacc     1260

tttcaaactt tcttcgtaac aatttagctc tgggaggcag ttttgccgta aaagtaacag     1320

agacaagttg gcatgagagt ttatatgaca ttgcacagga ttgtgcatgg tggacaatgt     1380

tttgtacagc agtgaatgct tcttcgtcag aagcattctt gattggtgtt aattatttgg     1440

gtgcaagtga aaaggttaga gttagtggta aaaccctgca cgcaaattat atattttgga     1500

ggaattgtaa ttatttacaa acttcagcct atagtatatt tgacgttgct aagtttgatt     1560

tgaaattaaa agcaacgcca gttgtgaatt tgaaaactga acaaaagaca gacttagtct     1620

ttaatttaat taagtgtggt aagttactgg taagagatgt tggacaaacc gcttttacta     1680

gtgactcttt ggtatgcact atgtagtgct ttgctctatg ataataatac ttacgtttac     1740

tactaccaaa gtgcctttag gcctggtcca ggttggcacc tatatggggg tgcttatgca     1800

gtagataggg tttttaatga aaccaacaat gcaggcagtg catctgattg cactgctggt     1860

actttttatg aaagccataa tatttctgct tcttctgtag ccatgacagt accacataat     1920

ggtatgtctt ggtcagcttc acaattttgt acagctcatt gtaacttctc agactttaca     1980

gtgttcgtta cgcattgttt taaaaatcaa ctcggtagtt gtcccttgac aggtatgatt     2040

cctcagaatc atattcgtat ttctgctatg agagatggag ttttgtttta taacttaaca     2100

gttagcgtat ctaaataccc tagatttaaa tcgcttcaat gtgttagcaa ttctacatct     2160

gtctatgtaa atggtgacct tgttttcact tctaatgaaa cttcttacgt tacgggtgca     2220

ggcgtttatt ttaaaagtgg tgggcctgta acttataaag ttatgaaaga agttaaagcc     2280

ctagcctact ttattaatgg taccgcacaa gaggttattt tatgtgataa ctcacctaga     2340

ggtttgcttg catgtcagta taacactggt aatttttcag atggattcta cccttttact     2400

aatcattctt tagttaagga taggtttatt gtatatcgag aaagtagcac taacactact     2460

tgtaagttaa ctaatttcag ttttactaat gtaagtaatg cttctcctaa ttcaggtggc     2520

gttgatactt tccaattata tcaaacaagt actgctcagg atggttatta taattttaat     2580

ttatcatttc tgagtagttt tgtgtataaa ccatctgatt ttatgtatgg gtcataccac     2640

ccacattgta agtttagacc agagaatatt aataatggct tatggtttaa ttcattatct     2700

gtgtcactta cttacggacc cattcaaggt ggttgtaagc aatctgtttt tagtaataga     2760

gcaacttgtt gctatgctta ttcttatcaa gggcctagta gatgtaaggg tgtttataga     2820

ggggagctaa cgcaatactt tgaatgtgga cttctagttt acgtaactaa gagtgatggc     2880

tctcgtatac aaactagaag tgaaccactg gtgttaactc aatataatta taacaacatt     2940

actttaaata agtgtgttga gtataatata tatggtaggg ttggtcaagg ttttattact     3000

aatgtaactg aagcaactgc taattatagt tatctagcag atggtggttt agctatttta     3060

gatacctcag gagccataga catatttgtt gttcaaggtg catatggtct taattattat     3120

aaggttaatc cctgtgaaga tgttaaccaa cagtttgtag tgtctggtgg caacttagtt     3180

ggcattctta catctcataa tgaaacaggt tctgaatcta ttgagaacca gttttacatc     3240

aaactcacta acggaacacg tcgctctaga cgttctgtta ctgggaatgt tacaaattgc     3300

ccttatgtta gttatggcaa gttttgtata aaaccagatg gttctttatc tataatagta     3360

ccacaagaat tagaacagtt tgtggcgcct ttattcaatg ttactgagca tgtgctcata     3420

cctgatagtt ttaatttaac tgtcacagat gagtacatac aaactcgtat ggataaggtt     3480

caaattattt gccttcagta tgtttgtggt aattctattg aatgcagaaa gttgtttcag     3540

cagtatggac ctgtttgtga taatatattg tctgttgtaa atggtgtagg tcaaagagag     3600

gatatggaac ttttaagttt ctattcttct actaaaccta gtggttacaa tacaccaatt     3660

tttaataatg ttagcactgg tgactttaat atttcgctcc tactaacacc acctaatagt     3720

cctactgggc gctcttttat tgaagatctt ctctttacaa gtgtagaatc tgttggatta     3780

ccaactgatg aagagtataa aaagtgtaca gcaggacctt taggttttgt taaagacctt     3840

gtttgtgcta gagagtataa tggtttgctc gttctgcctc ctattattac tgcggaaatg     3900

caaaccatgt atactagttc tttagtagcc tctatggctt taggtggcat tactgcagct     3960

ggtgctatac cttttgctac acaactgcag gccagaatta accatttggg tattactaat     4020

tctcttttgt tgaaaaacca agaaaaaatt gctgcttcct ttaataaggc catcggtcat     4080

atgcaggaag ggtttaaaag tacttctcta gcattacaac agattcaaga tgttgttaat     4140

aaacagagtt ctattcttac agagactatg caatcactta ataaaaattt tggtgctatt     4200

tcctctgtaa ttcaagacat ttaccagcaa ctagatgcta ttcaggcaga tgctcaggtt     4260

gatcgtctta ttacaggtag actctcttca ctatctgttt tagcttctgc taaacaggca     4320

gagtatcata gagtgtcaca acagcgtgag ttggccactc agaaaattaa tgagtgtgtt     4380

aagtctcagt ctaataggta ttcattttgt ggtaatggta gacatgttct aaccatacca     4440

cagaatgcac ccaatggcat agtgtttata cactttacat acactccaga gagttttgtt     4500

aatgttacgg caatagtagg gttttgcgta aacccagcta atgctagtca ttatgcaata     4560

gtgcctgtta atggcagggg tgtttttata gaagttaatg gtagttacta tatcactgct     4620

cgtgatatgt atatgccaag agatattact gcaggagaca tagtcacttt gacttcttgt     4680

caagcaaact atgttaatgt aaataaaacc gtcattaaca cttttgtgga agatgacgat     4740

tttgattttt atgatgaatt gtcaaaatgg tggaatgata ctaagcatga gctaccagat     4800

tttgatgaat tcaattatac cgttccagtt ttaaatatta gtaatgaaat tgacagaatt     4860

caacaggtta ttcagggatt aaatgattcc ctaatagacc ttgaaacact ctcaattctc     4920

aaaacttata ttaaatggcc ttggtatgtg tggcttgcca ttgcattcct taccattatt     4980

tttattctgg tactttgttg gatatttttc atgaccggtt gttgcggttg ttgttgtgga     5040

tgctttggta tcataccgtt aatgagtaag tgtggtaaga aatcttctta ctacacgact     5100

tttgataatg atgtggtaac ttaacaatac agacctaaaa agtctgttta atgattaaaa     5160

gtcccacatc ttttctaata ttattaattc ttctttggtg taaacttgca ttaagttgtt     5220

ttaaagagtg tgttataaca ctccagcaac tagtacaaat tttactccaa attattaata     5280

gtaacttaca atctagactt ctgctttggc acagtctaga ctaatgttag attttgaagc     5340

aattattgaa actggtcagc aaataactca acaaattagt ttctatttac agcatatttc     5400

aagggtgcta agtactgaat tatttgaccc ctttgaagtt tgtgtttaca gaggaggtaa     5460

ttgttgggag ttagagtcag ctgacgagtt ttcaggtgat gacgaatata ttgagtagat     5520

cgctcgagga gaacggaagt tttctaacag cggtttacgt gtttttagga tttttagcac     5580

tttatctact aggtagagcg cttcaagctt ttgtacaagc ggctgacgct tgttgtcttt     5640

tttggtatac atgggtagta gttcctggag ccaagggcac agcctttgtt tataatcata     5700

catatggtaa aaaacttaac aaaccggagt tagaaacggt tattgttaac gaatttccaa     5760

aaaacggttg gaaatatgga taataccatc aattgtactc ttggtactga acaagcagtt     5820

cagcttttta aggaatataa tctgtttgta actgcattcc tgttgttttt aaccatacta     5880

cttcagtatg gatacgcaac taggagcaag gttatttaca tactgaaaat gatagtgtta     5940

tggtgctttt ggccccttaa cattgcagta ggtgtaatct catgtatata cccaccaaac     6000

acaggaggtc ttgtcgcagc gataattctt acagtgtttg cgtgtctttc ttttataggt     6060

tattggatcc agagtattag actttttaag cggtgcaggt catggtggtc atttaacccc     6120

gaatctaatg ccgtaggttc aatactccta actaatggtc aacaatgtaa ttttgctata     6180

gagagtgtgc cgatggtgct ttctcctatt ataaagaatg gtgctcttta ttgcgagggt     6240

cagtggcttg ctaaatgtga accagaccac ttgcctagag atatatttgt atgcacaccg     6300

gatagacgta atatctatcg tatggtgcaa aaatatactg gtgaccaaag cggaagtaag     6360

aaaaggtttg ccacatttgt ctatgcaaag cagtcagtag atactggcga gctagaaagt     6420

gtgtcagcag taggaggtag tctttacaca taaatgtgtg tgtgtagaga gtatttaaaa     6480

ttattctttg acagtgcctc cgttttaaga gcgcggaaga gtattatttt tgaggatatt     6540

aatataaatc ctctttgttt catactctcc tttcaggagt tattatttaa aaaacagttt     6600

ttccactctt ttgtgccaaa aacaattgtt gttaatggtg taacctttca ggtagacaat     6660

ggaaaagtct actacgaagg aagaccaatt ttccaaaaag gttgttgtag tttgtggtcc     6720

aattataaga aagattagaa taattaaacc acctacaaca cttattttta caaatggcgt     6780

tttaggttac aaacgcttaa caaatacgga tgatgaaatg gctgactagt tttggaagag     6840

ctttcatctc ctgttataaa tccctattac taactcaatt aagagtatta gataggttaa     6900

ttttagatca cggacccaag cgcacattaa cgtgtgctag gcgagtgctt ttagttcaat     6960

tagatttagt ttataggttg gcttatacgc ccacccaatc gctggtatga ataatagtaa     7020

agataatcct tttcgcggag caatagcaag aaaagcgcga atttatctga gaggaggatt     7080

agattgtgtt tactttctta acaaagcagg acaagcagag ccttgtcccg cgtgtacctc     7140

cctagtattc caagggaaaa cttgtgagga acactattat aataacaatc ttttgtcatg     7200

gcaagcggta aggcaactgg aaagacagac gccccagcgc cagtcatcaa actaggagga     7260

ccaaagccac ctaaagttgg ttcttctgga aatgcatcat ggtttcaacc gataaaggcc     7320

aagaagctaa attcacctgt gcctaaattt gacggtagtg gtgttcctga aaatgaaaat     7380

ctcaagtcaa gccagcaaca tggatactgg agacgccaac acaggtttaa gcctggcaaa     7440

ggtggaagaa aaccagtccc tgatgcttgg tacttttact acactggaac aggaccggcc     7500

gccgacctga attggggtga aactcaagat ggtatagtgt gggttgctgc aaagggtgct     7560

gatactaaat ctagatcaaa ccagggtaca agggatcctg ataagtttga ccaataccca     7620

ctacgattct cagatggagg accggatggt aatttccgtt gggacttcat accaataaat     7680

cgtggtagga gtgggagatc aacagcagct tcatcagcag catctagtag agcaccatct     7740

cgtgaggggt cacgtggacg tagaagcgga gttgaagatg atcttatagc tcgcgcagca     7800

aagattatac aggaccagca aaagaagggt gcgcgcatta ccaaggctaa ggctgatgaa     7860

atggctcatc gccgctattg caagcgcact atcccacctg gttataaggt tgagcaagta     7920

tttggtcccc gtactaaagg taaggaagga aattttggtg atgacaagat gaatgaggaa     7980

ggtgttaagg atgggcgtgt tacggcaatg ctcaacctag tccctagcag tcatgcttgt     8040

ctttttggaa gtagggtgac gcccaaactg cagccagatg gtcttcacct gagatttgaa     8100

tttactactg tggtgtcacg tgatgatccg cagtttgata attatgtgaa aatttgtgat     8160

cagtgtgtcg atggtgtagg gacgcgtcca aaggacgatg aatcgagacc aaagtcacgc     8220

ccaaattcaa gacctgcaac tagaggaaat tctccagcgc cgagacaaca gcgcccaaag     8280

aaggagaaaa agcccaagaa gcaggatgat gaagtagata aggcattgac ctcagatgag     8340

gagaggaaca atgcacagct ggaatttgat gatgaaccca aggtgattaa ctggggggac     8400

tctgcactag gtgaaaatga actttgatta acataatgga cttgctgcat ttgctgtcac     8460

attttgttaa atattatttt tgtgttttac tatcaattat tacaggtatt gattgtgatt     8520

atgttcaata cttaagcttc ttctggttgc tttttgcttg ttgtattgtt gctgtgcttt     8580

ttattattgt gattctcatt agtttgcttt atcgtagaaa ttcaatagta agagttaagg     8640

aagataggca tgtagcttag cacctacatg tctatcgcca gggaaatgtc taatctgtct     8700

acttagtagc ctggaaacga acggtagacc cttagatttt aatttagttt aatttttagt     8760

ttagtttaag ttagtttaga gtaggtataa agatgccagt gccggggcca cgcgtagtac     8820

gaccgagggt acagcactag gacgcccact aggggaagag ctaaatttta gtttaagtta     8880

agtttaattg gctaaatata gttaaaattt ataggctagt atagagttag agcaaaaaaa     8940

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     9000

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaagcggccg catcggatgc cgggaccgac     9060

gagtgcagag gcgtgcaagc gagcttggcg taatcatggt catagctgtt tcctgtgtga     9120

aattgttatc cgctcacaat tccacacaac atacgagccg gaagcataaa gtgtaaagcc     9180

tggggtgcct aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc     9240

cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc     9300

ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt     9360

cggctgcggc gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca     9420

ggggataacg caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa     9480

aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat     9540

cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc     9600

cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc     9660

gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt     9720

tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac     9780

cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg     9840

ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca     9900

gagttcttga agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc     9960

gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa    10020

accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa    10080

ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac    10140

tcacgttaag ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta    10200

aattaaaaat gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt    10260

taccaatgct taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata    10320

gttgcctgac tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc    10380

agtgctgcaa tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac    10440

cagccagccg gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag    10500

tctattaatt gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac    10560

gttgttgcca ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc    10620

agctccggtt cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg    10680

gttagctcct tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc    10740

atggttatgg cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct    10800

gtgactggtg agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc    10860

tcttgcccgg cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc    10920

atcattggaa aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc    10980

agttcgatgt aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc    11040

gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca    11100

cggaaatgtt gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt    11160

tattgtctca tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt    11220

ccgcgcacat ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca    11280

ttaacctata aaaataggcg tatcacgagg ccctttcgtc                          11320


<210>  15
<211>  11320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid Sequence

<400>  15
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt ggagatcggt acttcgcgaa      420

tgcgtcgaga tgagctctaa tacgactcac tatagggact taagtgtgat ataaatatat      480

atcatacata ctagccttgt gctagatttc caacttaaca aaacggactt aaatacctac      540

agttggtccc tataggtgtt ccattgcagt gcactttagt gccctggatg gcacctggcc      600

acctgtcagg tttttgttat taaaataata ttgttgctgg tatcactgct tgttttgccg      660

tgtctcactt tatacatccg ttgcttgggc tacctagtat ccagcgtcct actggcgttg      720

tggtcggttc gagtgcgaag aacctctggt tcatctagcg gtacgcgggt gtgtggaagt      780

agcgcttcag acgtaccggt tctgttgcgt gaaatacggg gtcacctccc cccacatacc      840

tctaagggct tttgagccta gcgttgggct acgttctcgc acaaggtcgg ctatacggcg      900

tttgtagggg gtagtgccaa acaacccctg aggtgacagg ttctggtggt gtttcgaaaa      960

caacaatgtg tgtgccgcat aatatgcgag taatgcattt tggagcagga agtgacaaag     1020

gagtggcccc aggtagcgct gttcttaggc agtggcttcc cgaaggtaca ctccttgtcg     1080

ataatgatat tgtagattat gtatctgatg cacatgtctc tgtgctttca gattgcaata     1140

aatgtaaaac agagcacaag tttgatcttg tgatatctga tatgtataca gataatgatt     1200

caaagagaaa gcatgaaggc gttgtagcca ataacggcaa tgatgacgtc ttcatatacc     1260

tttcaaactt tcttcgtaac aatttagctc tgggaggcag ttttgccgta aaagtaacag     1320

agacaagttg gcatgagagt ttatatgaca ttgcacagga ttgtgcatgg tggacaatgt     1380

tttgtacagc agtgaatgct tcttcgtcag aagcattctt gattggtgtt aattatttgg     1440

gtgcaagtga aaaggttaga gttagtggta aaaccctgca cgcaaattat atattttgga     1500

ggaattgtaa ttatttacaa acttcagcct atagtatatt tgacgttgct aagtttgatt     1560

tgaaattaaa agcaacgcca gttgtgaatt tgaaaactga acaaaagaca gacttagtct     1620

ttaatttaat taagtgtggt aagttactgg taagagatgt tggacaaacc gcttttacta     1680

gtgactcttt ggtatgcact atgtagtgct ttgctctatg ataataatac ttacgtttac     1740

tactaccaaa gtgcctttag gcctggtcca ggttggcacc tatatggggg tgcttatgca     1800

gtagataggg tttttaatga aaccaacaat gcaggcagtg catctgattg cactgctggt     1860

actttttatg aaagccataa tatttctgct tcttctgtag ccatgacagt accacataat     1920

ggtatgtctt ggtcagcttc acaattttgt acagctcatt gtaacttctc agactttaca     1980

gtgttcgtta cgcattgttt taaaaatcaa ctcggtagtt gtcccttgac aggtatgatt     2040

cctcagaatc atattcgtat ttctgctatg agagatggag ttttgtttta taacttaaca     2100

gttagcgtat ctaaataccc tagatttaaa tcgcttcaat gtgttagcaa ttctacatct     2160

gtctatgtaa atggtgacct tgttttcact tctaatgaaa cttcttacgt tacgggtgca     2220

ggcgtttatt ttaaaagtgg tgggcctgta acttataaag ttatgaaaga agttaaagcc     2280

ctagcctact ttattaatgg taccgcacaa gaggttattt tatgtgataa ctcacctaga     2340

ggtttgcttg catgtcagta taacactggt aatttttcag atggattcta cccttttact     2400

aatcattctt tagttaagga taggtttatt gtatatcgag aaagtagcac taacactact     2460

tgtaagttaa ctaatttcag ttttactaat gtaagtaatg cttctcctaa ttcaggtggc     2520

gttgatactt tccaattata tcaaacaagt actgctcagg atggttatta taattttaat     2580

ttatcatttc tgagtagttt tgtgtataaa ccatctgatt ttatgtatgg gtcataccac     2640

ccacattgta agtttagacc agagaatatt aataatggct tatggtttaa ttcattatct     2700

gtgtcactta cttacggacc cattcaaggt ggttgtaagc aatctgtttt tagtaataga     2760

gcaacttgtt gctatgctta ttcttatcaa gggcctagta gatgtaaggg tgtttataga     2820

ggggagctaa cgcaatactt tgaatgtgga cttctagttt acgtaactaa gagtgatggc     2880

tctcgtatac aaactagaag tgaaccactg gtgttaactc aatataatta taacaacatt     2940

actttaaata agtgtgttga gtataatata tatggtaggg ttggtcaagg ttttattact     3000

aatgtaactg aagcaactgc taattatagt tatctagcag atggtggttt agctatttta     3060

gatacctcag gagccataga catatttgtt gttcaaggtg catatggtct taattattat     3120

aaggttaatc cctgtgaaga tgttaaccaa cagtttgtag tgtctggtgg caacttagtt     3180

ggcattctta catctcataa tgaaacaggt tctgaatcta ttgagaacca gttttacatc     3240

aaactcacta acggaacacg tcgctctaga cgttctgtta ctgggaatgt tacaaattgc     3300

ccttatgtta gttatggcaa gttttgtata aaaccagatg gttctttatc tataatagta     3360

ccacaagaat tagaacagtt tgtggcgcct ttattcaatg ttactgagca tgtgctcata     3420

cctgatagtt ttaatttaac tgtcacagat gagtacatac aaactcgtat ggataaggtt     3480

caaattattt gccttcagta tgtttgtggt aattctattg aatgcagaaa gttgtttcag     3540

cagtatggac ctgtttgtga taatatattg tctgttgtaa atggtgtagg tcaaagagag     3600

gatatggaac ttttaagttt ctattcttct actaaaccta gtggttacaa tacaccaatt     3660

tttaataatg ttagcactgg tgactttaat atttcgctcc tactaacacc acctaatagt     3720

cctactgggc gctcttttat tgaagatctt ctctttacaa gtgtagaatc tgttggatta     3780

ccaactgatg aagagtataa aaagtgtaca gcaggacctt taggttttgt taaagacctt     3840

gtttgtgcta gagagtataa tggtttgctc gttctgcctc ctattattac tgcggaaatg     3900

caaaccatgt atactagttc tttagtagcc tctatggctt taggtggcat tactgcagct     3960

ggtgctatac cttttgctac acaactgcag gccagaatta accatttggg tattactaat     4020

tctcttttgt tgaaaaacca agaaaaaatt gctgcttcct ttaataaggc catcggtcat     4080

atgcaggaag ggtttaaaag tacttctcta gcattacaac agattcaaga tgttgttaat     4140

aaacagagtt ctattcttac agagactatg caatcactta ataaaaattt tggtgctatt     4200

tcctctgtaa ttcaagacat ttaccagcaa ctagatgcta ttcaggcaga tgctcaggtt     4260

gatcgtctta ttacaggtag actctcttca ctatctgttt tagcttctgc taaacaggca     4320

gagtatcata gagtgtcaca acagcgtgag ttggccactc agaaaattaa tgagtgtgtt     4380

aagtctcagt ctaataggta ttcattttgt ggtaatggta gacatgttct aaccatacca     4440

cagaatgcac ccaatggcat agtgtttata cactttacat acactccaga gagttttgtt     4500

aatgttacgg caatagtagg gttttgcgta aacccagcta atgctagtca ttatgcaata     4560

gtgcctgtta atggcagggg tgtttttata gaagttaatg gtagttacta tatcactgct     4620

cgtgatatgt atatgccaag agatattact gcaggagaca tagtcacttt gacttcttgt     4680

caagcaaact atgttaatgt aaataaaacc gtcattaaca cttttgtgga agatgacgat     4740

tttgattttt atgatgaatt gtcaaaatgg tggaatgata ctaagcatga gctaccagat     4800

tttgatgaat tcaattatac cgttccagtt ttaaatatta gtaatgaaat tgacagaatt     4860

caacaggtta ttcagggatt aaatgattcc ctaatagacc ttgaaacact ctcaattctc     4920

aaaacttata ttaaatggcc ttggtatgtg tggcttgcca ttgcattcct taccattatt     4980

tttattctgg tactttgttg gatatttttc atgaccggtt gttgcggttg ttgttgtgga     5040

tgctttggta tcataccgtt aatgagtaag tgtggtaaga aatcttctta ctacacgact     5100

tttgataatg atgtggtaac ttaacaatac agacctaaaa agtctgttta atgattaaaa     5160

gtcccacatc ttttctaata ttattaattc ttctttggtg taaacttgca ttaagttgtt     5220

ttaaagagtg tgttataaca ctccagcaac tagtacaaat tttactccaa attattaata     5280

gtaacttaca atctagactt ctgctttggc acagtctaga ctaatgttag attttgaagc     5340

aattattgaa actggtcagc aaataactca acaaattagt ttctatttac agcatatttc     5400

aagggtgcta agtactgaat tatttgaccc ctttgaagtt tgtgtttaca gaggaggtaa     5460

ttgttgggag ttagagtcag ctgacgagtt ttcaggtgat gacgaatata ttgagtagat     5520

cgctcgagga gaacggaagt tttctaacag cggtttacgt gtttttagga tttttagcac     5580

tttatctact aggtagagcg cttcaagctt ttgtacaagc ggctgacgct tgttgtcttt     5640

tttggtatac atgggtagta gttcctggag ccaagggcac agcctttgtt tataatcata     5700

catatggtaa aaaacttaac aaaccggagt tagaaacggt tattgttaac gaatttccaa     5760

aaaacggttg gaaatatgga taataccatc aattgtactc ttggtactga acaagcagtt     5820

cagcttttta aggaatataa tctgtttgta actgcattcc tgttgttttt aaccatacta     5880

cttcagtatg gatacgcaac taggagcaag gttatttaca tactgaaaat gatagtgtta     5940

tggtgctttt ggccccttaa cattgcagta ggtgtaatct catgtatata cccaccaaac     6000

acaggaggtc ttgtcgcagc gataattctt acagtgtttg cgtgtctttc ttttataggt     6060

tattggatcc agagtattag actttttaag cggtgcaggt catggtggtc atttaacccc     6120

gaatctaatg ccgtaggttc aatactccta actaatggtc aacaatgtaa ttttgctata     6180

gagagtgtgc cgatggtgct ttctcctatt ataaagaatg gtgctcttta ttgcgagggt     6240

cagtggcttg ctaaatgtga accagaccac ttgcctagag atatatttgt atgcacaccg     6300

gatagacgta atatctatcg tatggtgcaa aaatatactg gtgaccaaag cggaagtaag     6360

aaaaggtttg ccacatttgt ctatgcaaag cagtcagtag atactggcga gctagaaagt     6420

gtgtcagcag taggaggtag tctttacaca taaatgtgtg tgtgtagaga gtatttaaaa     6480

ttattctttg acagtgcctc cgttttaaga gcgcggaaga gtattatttt tgaggatatt     6540

aatataaatc ctctttgttt catactctcc tttcaggagt tattatttaa aaaacagttt     6600

ttccactctt ttgtgccaaa aacaattgtt gttaatggtg taacctttca ggtagacaat     6660

ggaaaagtct actacgaagg aagaccaatt ttccaaaaag gttgttgtag tttgtggtcc     6720

aattataaga aagattagaa taattaaacc acctacaaca cttattttta caaatggcgt     6780

tttaggttac aaacgcttaa caaatacgga tgatgaaatg gctgactagt tttggaagag     6840

ctttcatctc ctgttataaa tccctattac taactcaatt aagagtatta gataggttaa     6900

ttttagatca cggacccaag cgcacattaa cgtgtgctag gcgagtgctt ttagttcaat     6960

tagatttagt ttataggttg gcttatacgc ccacccaatc gctggtatga ataatagtaa     7020

agataatcct tttcgcggag caatagcaag aaaagcgcga atttatctga gaggaggatt     7080

agattgtgtt tactttctta acaaagcagg acaagcagag ccttgtcccg cgtgtacctc     7140

cctagtattc caagggaaaa cttgtgagga acactattat aataacaatc ttttgtcatg     7200

gcaagcggta aggcaactgg aaagacagac gccccagcgc cagtcatcaa actaggagga     7260

ccaaagccac ctaaagttgg ttcttctgga aatgcatcat ggtttcaacc gataaaggcc     7320

aagaagctaa attcacctgt gcctaaattt gacggtagtg gtgttcctga aaatgaaaat     7380

ctcaagtcaa gccagcaaca tggatactgg agacgccaac acaggtttaa gcctggcaaa     7440

ggtggaagaa aaccagtccc tgatgcttgg tacttttact acactggaac aggaccggcc     7500

gccgacctga attggggtga aactcaagat ggtatagtgt gggttgctgc aaagggtgct     7560

gatactaaat ctagatcaaa ccagggtaca agggatcctg ataagtttga ccaataccca     7620

ctacgattct cagatggagg accggatggt aatttccgtt gggacttcat accaataaat     7680

cgtggtagga gtgggagatc aacagcagct tcatcagcag catctagtag agcaccatct     7740

cgtgaggggt cacgtggacg tagaagcgga gttgaagatg atcttatagc tcgcgcagca     7800

aagattatac aggaccagca aaagaagggt gcgcgcatta ccaaggctaa ggctgatgaa     7860

atggctcatc gccgctattg caagcgcact atcccacctg gttataaggt tgagcaagta     7920

tttggtcccc gtactaaagg taaggaagga aattttggtg atgacaagat gaatgaggaa     7980

ggtgttaagg atgggcgtgt tacggcaatg ctcaacctag tccctagcag tcatgcttgt     8040

ctttttggaa gtagggtgac gcccaaactg cagccagatg gtcttcacct gagatttgaa     8100

tttactactg tggtgtcacg tgatgatccg cagtttgata attatgtgaa aatttgtgat     8160

cagtgtgtcg atggtgtagg gacgcgtcca aaggacgatg aatcgagacc aaagtcacgc     8220

ccaaattcaa gacctgcaac tagaggaaat tctccagcgc cgagacaaca gcgcccaaag     8280

aaggagaaaa agcccaagaa gcaggatgat gaagtagata aggcattgac ctcagatgag     8340

gagaggaaca atgcacagct ggaatttgat gatgaaccca aggtgattaa ctggggggac     8400

tctgcactag gtgaaaatga actttgatta acataatgga cttgctgcat ttgctgtcac     8460

attttgttaa atattatttt tgtgttttac tatcaattat tacaggtatt gattgtgatt     8520

atgttcaata cttaagcttc ttctggttgc tttttgcttg ttgtattgtt gctgtgcttt     8580

ttattattgt gattctcatt agtttgcttt atcgtagaaa ttcaatagta agagttaagg     8640

aagataggca tgtagcttag cacctacatg tctatcgcca gggaaatgtc taatctgtct     8700

acttagtagc ctggaaacga acggtagacc cttagatttt aatttagttt aatttttagt     8760

ttagtttaag ttagtttaga gtaggtataa agatgccagt gccggggcca cgcgtagtac     8820

gaccgagggt acagcactag gacgcccact aggggaagag ctaaatttta gtttaagtta     8880

agtttaattg gctaaatata gttaaaattt ataggctagt atagagttag agcaaaaaaa     8940

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     9000

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaagcggccg catcggatgc cgggaccgac     9060

gagtgcagag gcgtgcaagc gagcttggcg taatcatggt catagctgtt tcctgtgtga     9120

aattgttatc cgctcacaat tccacacaac atacgagccg gaagcataaa gtgtaaagcc     9180

tggggtgcct aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc     9240

cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc     9300

ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt     9360

cggctgcggc gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca     9420

ggggataacg caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa     9480

aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat     9540

cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc     9600

cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc     9660

gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt     9720

tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac     9780

cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg     9840

ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca     9900

gagttcttga agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc     9960

gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa    10020

accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa    10080

ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac    10140

tcacgttaag ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta    10200

aattaaaaat gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt    10260

taccaatgct taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata    10320

gttgcctgac tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc    10380

agtgctgcaa tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac    10440

cagccagccg gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag    10500

tctattaatt gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac    10560

gttgttgcca ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc    10620

agctccggtt cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg    10680

gttagctcct tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc    10740

atggttatgg cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct    10800

gtgactggtg agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc    10860

tcttgcccgg cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc    10920

atcattggaa aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc    10980

agttcgatgt aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc    11040

gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca    11100

cggaaatgtt gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt    11160

tattgtctca tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt    11220

ccgcgcacat ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca    11280

ttaacctata aaaataggcg tatcacgagg ccctttcgtc                          11320


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  16
cggataacaa tttcacacag g                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  17
aacactattt tcacgataga c                                                 21


<210>  18
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  18
aatactactt gtacgttaca caatttc                                           27


<210>  19
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  19
taaatggtga tcttgttt                                                     18


<210>  20
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  20
gcattcactg ctgtacaa                                                     18


<210>  21
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  21
cgctcttagt aacataaac                                                    19


<210>  22
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  22
ctgaggtcaa tgctttatc                                                    19


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  23
gacagagcac aagtttgatc                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  24
acttcaagca tttgtacagg                                                   20


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  25
ggtcaacaat gtaattttgc t                                                 21


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  26
gcagatgcta aaacagaaag                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  27
tcacctgaac aatcttcagc                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  28
ggtcaccagt atatttctgc                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  29
aaagaagcag gatgatgaag                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  30
aagagatgtt ggtaacacct                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  31
ctaaaccggc tggttttaat                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  32
ccatagcttt tgccactatt                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  33
cgcttgtaaa tagaaggtct                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  34
acataccaag gccacttaat                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  35
ggtcctgttc cagtatagta                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  36
cttgtcctgc tttgttaaga                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  37
gtggatcgtc ttataactgg                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  38
ctcgcattac aaaggctaag                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  39
ccagttatag gacacccatc                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  40
gttggttctt ctggaaatgt                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  41
tcagcatgga cgtgtggtta                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  42
ccccatgtaa atgccaacca                                                   20


<210>  43
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  43
gtatatcgag aaagtagcac taacactact tgtaagttaa ctaatttcag ttttactaat       60

g                                                                       61


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  44
tttgtatacg agagccatca                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  45
tcagcgtgga catgtggtta                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  46
ccccatatag gtgccaacct                                                   20


<210>  47
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  47
cgcggatccg ccaccatgtt ggtgaagtca ctg                                    33


<210>  48
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  48
gcggcggccg cttaaacaga ctttttaggt ctg                                    33


<210>  49
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  49
taatactact tgtgcgttaa ctaattttac ttttagtaat g                           41


<210>  50
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  50
acactacttt cacgatag                                                     18


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  51
aatttaacag ttagcgtatc                                                   20


<210>  52
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  52
aagtgtggta agttactggt aagagatgtt ggtgaagtca ctg                         43


<210>  53
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  53
agaaaagatg tgggactttt aatcattaaa cagacttttt aggtctg                     47


<210>  54
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  54
tgattaaaag tcccacatct tttctaatat tattaattct tctttgg                     47


<210>  55
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  55
ctcttaccag taacttacca cacttaatta aattaaagac taagtc                      46


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  56
caggattgtg catggtggac                                                   20


<210>  57
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  57
gaagtgaaya caagatcacc attt                                              24


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  58
tgactgattc tgctgctaaa                                                   20


<210>  59
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  59
tcttgaaacc cccaagtag                                                    19


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  60
tatattcagc atcagttggc                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  61
ggattttgtg gtagtggaag                                                   20


<210>  62
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  62
ccactattgc agtaacatta aca                                               23


<210>  63
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  63
ctagactgta agttactatt g                                                 21


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  64
ccagggtttt cccagtcacg                                                   20


<210>  65
<211>  1156
<212>  PRT
<213>  Avian infectious bronchitis virus

<400>  65

Met Leu Val Lys Ser Leu Phe Leu Val Thr Ile Leu Cys Ala Leu Cys 
1               5                   10                  15      


Ser Ala Asn Leu Phe Asp Ser Asp Asn Asn Tyr Val Tyr Tyr Tyr Gln 
            20                  25                  30          


Ser Ala Phe Arg Pro Pro Asn Gly Trp His Leu Gln Gly Gly Ala Tyr 
        35                  40                  45              


Ala Val Val Ser Ser Thr Asn Tyr Thr Asn Asn Ala Gly Ser Ala His 
    50                  55                  60                  


Gly Cys Thr Val Gly Val Ile Lys Asp Val Tyr Asn Gln Ser Val Ala 
65                  70                  75                  80  


Ser Ile Ala Met Thr Ala Pro Leu Gln Gly Met Ala Trp Ser Lys Ser 
                85                  90                  95      


Gln Phe Cys Ser Ala His Cys Asn Phe Ser Glu Ile Thr Val Phe Val 
            100                 105                 110         


Thr His Cys Tyr Ser Ser Gly Ser Gly Ser Cys Pro Ile Thr Gly Met 
        115                 120                 125             


Ile Pro Arg Asp His Ile Arg Ile Ser Ala Met Lys Asn Gly Ser Leu 
    130                 135                 140                 


Phe Tyr Asn Leu Thr Val Ser Val Ser Lys Tyr Pro Asn Phe Lys Ser 
145                 150                 155                 160 


Phe Gln Cys Val Asn Asn Phe Thr Ser Val Tyr Leu Asn Gly Asp Leu 
                165                 170                 175     


Val Phe Thr Ser Asn Lys Thr Thr Asp Val Thr Ser Ala Gly Val Tyr 
            180                 185                 190         


Phe Lys Ala Gly Gly Pro Val Asn Tyr Ser Ile Met Lys Glu Phe Lys 
        195                 200                 205             


Val Leu Ala Tyr Phe Val Asn Gly Thr Ala Gln Asp Val Val Leu Cys 
    210                 215                 220                 


Asp Asn Ser Pro Lys Gly Leu Leu Ala Cys Gln Tyr Asn Thr Gly Asn 
225                 230                 235                 240 


Phe Ser Asp Gly Phe Tyr Pro Phe Thr Asn Ser Thr Leu Val Arg Glu 
                245                 250                 255     


Lys Phe Ile Val Tyr Arg Glu Ser Ser Val Asn Thr Thr Leu Ala Leu 
            260                 265                 270         


Thr Asn Phe Thr Phe Ser Asn Val Ser Asn Ala Gln Pro Asn Ser Gly 
        275                 280                 285             


Gly Val Asn Thr Phe His Leu Tyr Gln Thr Gln Thr Ala Gln Ser Gly 
    290                 295                 300                 


Tyr Tyr Asn Phe Asn Leu Ser Phe Leu Ser Gln Phe Val Tyr Lys Ala 
305                 310                 315                 320 


Ser Asp Phe Met Tyr Gly Ser Tyr His Pro Ser Cys Ser Phe Arg Pro 
                325                 330                 335     


Glu Thr Ile Asn Ser Gly Leu Trp Phe Asn Ser Leu Ser Val Ser Leu 
            340                 345                 350         


Thr Tyr Gly Pro Leu Gln Gly Gly Cys Lys Gln Ser Val Phe Ser Gly 
        355                 360                 365             


Lys Ala Thr Cys Cys Tyr Ala Tyr Ser Tyr Arg Gly Pro Met Ala Cys 
    370                 375                 380                 


Lys Gly Val Tyr Ser Gly Glu Leu Ser Thr Asn Phe Glu Cys Gly Leu 
385                 390                 395                 400 


Leu Val Tyr Val Thr Lys Ser Asp Gly Ser Arg Ile Gln Thr Arg Thr 
                405                 410                 415     


Glu Pro Leu Val Leu Thr Gln Tyr Asn Tyr Asn Asn Ile Thr Leu Asp 
            420                 425                 430         


Lys Cys Val Ala Tyr Asn Ile Tyr Gly Arg Val Gly Gln Gly Phe Ile 
        435                 440                 445             


Thr Asn Val Thr Asp Ser Ala Ala Asn Phe Ser Tyr Leu Ala Asp Gly 
    450                 455                 460                 


Gly Leu Ala Ile Leu Asp Thr Ser Gly Ala Ile Asp Val Phe Val Val 
465                 470                 475                 480 


Gln Gly Ile Tyr Gly Leu Asn Tyr Tyr Lys Val Asn Pro Cys Glu Asp 
                485                 490                 495     


Val Asn Gln Gln Phe Val Val Ser Gly Gly Asn Ile Val Gly Ile Leu 
            500                 505                 510         


Thr Ser Arg Asn Glu Thr Gly Ser Glu Gln Val Glu Asn Gln Phe Tyr 
        515                 520                 525             


Val Lys Leu Thr Asn Ser Ser His Arg Arg Lys Arg Ser Ile Gly Gln 
    530                 535                 540                 


Asn Val Thr Ser Cys Pro Tyr Val Ser Tyr Gly Arg Phe Cys Ile Glu 
545                 550                 555                 560 


Pro Asp Gly Ser Leu Lys Met Ile Val Pro Glu Glu Leu Lys Gln Phe 
                565                 570                 575     


Val Ala Pro Leu Leu Asn Ile Thr Glu Ser Val Leu Ile Pro Asn Ser 
            580                 585                 590         


Phe Asn Leu Thr Val Thr Asp Glu Tyr Ile Gln Thr Arg Met Asp Lys 
        595                 600                 605             


Val Gln Ile Asn Cys Leu Gln Tyr Val Cys Gly Asn Ser Leu Glu Cys 
    610                 615                 620                 


Arg Lys Leu Phe Gln Gln Tyr Gly Pro Val Cys Asp Asn Ile Leu Ser 
625                 630                 635                 640 


Val Val Asn Ser Val Ser Gln Lys Glu Asp Met Glu Leu Leu Ser Phe 
                645                 650                 655     


Tyr Ser Ser Thr Lys Pro Lys Gly Tyr Asp Thr Pro Val Leu Ser Asn 
            660                 665                 670         


Val Ser Thr Gly Glu Phe Asn Ile Ser Leu Leu Leu Lys Pro Pro Ser 
        675                 680                 685             


Ser Pro Ser Gly Arg Ser Phe Ile Glu Glu Leu Leu Phe Thr Ser Val 
    690                 695                 700                 


Glu Thr Val Gly Leu Pro Thr Asp Ala Glu Tyr Lys Lys Cys Thr Ala 
705                 710                 715                 720 


Gly Pro Leu Gly Thr Leu Lys Asp Leu Ile Cys Ala Arg Glu Tyr Asn 
                725                 730                 735     


Gly Leu Leu Val Leu Pro Pro Ile Ile Thr Ala Asp Met Gln Thr Met 
            740                 745                 750         


Tyr Thr Ala Ser Leu Val Gly Ala Met Ala Phe Gly Gly Ile Thr Ser 
        755                 760                 765             


Ala Ala Ala Ile Pro Phe Ala Thr Gln Ile Gln Ala Arg Ile Asn His 
    770                 775                 780                 


Leu Gly Ile Thr Gln Ser Leu Leu Met Lys Asn Gln Glu Lys Ile Ala 
785                 790                 795                 800 


Ala Ser Phe Asn Lys Ala Ile Gly His Met Gln Glu Gly Phe Arg Ser 
                805                 810                 815     


Thr Ser Leu Ala Leu Gln Gln Ile Gln Asp Val Val Asn Lys Gln Ser 
            820                 825                 830         


Ala Ile Leu Thr Glu Thr Met Asn Ser Leu Asn Lys Asn Phe Gly Ala 
        835                 840                 845             


Ile Thr Ser Val Ile Gln Asp Ile Tyr Ala Gln Leu Asp Ala Ile Gln 
    850                 855                 860                 


Ala Asp Ala Gln Val Asp Arg Leu Ile Thr Gly Arg Leu Ser Ser Leu 
865                 870                 875                 880 


Ser Val Leu Ala Ser Ala Lys Gln Ser Glu Tyr Ile Arg Val Ser Gln 
                885                 890                 895     


Gln Arg Glu Leu Ala Thr Gln Lys Ile Asn Glu Cys Val Lys Ser Gln 
            900                 905                 910         


Ser Asn Arg Tyr Gly Phe Cys Gly Ser Gly Arg His Val Leu Ser Ile 
        915                 920                 925             


Pro Gln Asn Ala Pro Asn Gly Ile Val Phe Ile His Phe Thr Tyr Thr 
    930                 935                 940                 


Pro Glu Ser Phe Val Asn Val Thr Ala Ile Val Gly Phe Cys Val Asn 
945                 950                 955                 960 


Pro Ala Asn Ala Ser Gln Tyr Ala Ile Val Pro Ala Asn Gly Arg Gly 
                965                 970                 975     


Ile Phe Ile Gln Val Asn Gly Thr Tyr Tyr Ile Thr Ala Arg Asp Met 
            980                 985                 990         


Tyr Met Pro Arg Asp Ile Thr Ala  Gly Asp Ile Val Thr  Leu Thr Ser 
        995                 1000                 1005             


Cys Gln  Ala Asn Tyr Val Asn  Val Asn Lys Thr Val  Ile Thr Thr 
    1010                 1015                 1020             


Phe Val  Glu Asp Asp Asp Phe  Asp Phe Asp Asp Glu  Leu Ser Lys 
    1025                 1030                 1035             


Trp Trp  Asn Asp Thr Lys His  Gln Leu Pro Asp Phe  Asp Asp Phe 
    1040                 1045                 1050             


Asn Tyr  Thr Val Pro Ile Leu  Asn Ile Ser Gly Glu  Ile Asp Tyr 
    1055                 1060                 1065             


Ile Gln  Gly Val Ile Gln Gly  Leu Asn Asp Ser Leu  Ile Asp Leu 
    1070                 1075                 1080             


Glu Glu  Leu Ser Ile Ile Lys  Thr Tyr Ile Lys Trp  Pro Trp Tyr 
    1085                 1090                 1095             


Val Trp  Leu Ala Ile Phe Phe  Ala Ile Ile Ile Phe  Ile Leu Ile 
    1100                 1105                 1110             


Leu Gly  Trp Val Phe Phe Met  Thr Gly Cys Cys Gly  Cys Cys Cys 
    1115                 1120                 1125             


Gly Cys  Phe Gly Ile Ile Pro  Leu Met Ser Lys Cys  Gly Lys Lys 
    1130                 1135                 1140             


Ser Ser  Tyr Tyr Thr Thr Phe  Asp Asn Asp Val Val  Thr 
    1145                 1150                 1155     


<210>  66
<211>  6523
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid Sequence

<400>  66
aatcactagt gcggccgcct gcaggtcgac catatgggag agctcccaac gcgttggatg       60

catagcttga gtattctata gtgtcaccta aatagcttgg cgtaatcatg gtcatagctg      120

tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc cggaagcata      180

aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc gttgcgctca      240

ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc      300

gcggggagag gcggtttgcg tattgggcgc tcttccgctt cctcgctcac tgactcgctg      360

cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta      420

tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc      480

aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag      540

catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac      600

caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc      660

ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt      720

aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc      780

gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga      840

cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta      900

ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aagaacagta      960

tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga     1020

tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg     1080

cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag     1140

tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc     1200

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact     1260

tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt     1320

cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta     1380

ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta     1440

tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc     1500

gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat     1560

agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt     1620

atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg     1680

tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca     1740

gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta     1800

agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg     1860

cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact     1920

ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg     1980

ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt     2040

actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga     2100

ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc     2160

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa     2220

caaatagggg ttccgcgcac atttccccga aaagtgccac ctgatgcggt gtgaaatacc     2280

gcacagatgc gtaaggagaa aataccgcat caggaaattg taagcgttaa tattttgtta     2340

aaattcgcgt taaatttttg ttaaatcagc tcatttttta accaataggc cgaaatcggc     2400

aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt tccagtttgg     2460

aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa aaccgtctat     2520

cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg gtcgaggtgc     2580

cgtaaagcac taaatcggaa ccctaaaggg agcccccgat ttagagcttg acggggaaag     2640

ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggcgc tagggcgctg     2700

gcaagtgtag cggtcacgct gcgcgtaacc accacacccg ccgcgcttaa tgcgccgcta     2760

cagggcgcgt ccattcgcca ttcaggctgc gcaactgttg ggaagggcga tcggtgcggg     2820

cctcttcgct attacgccag ctggcgaaag ggggatgtgc tgcaaggcga ttaagttggg     2880

taacgccagg gttttcccag tcacgacgtt gtaaaacgac ggccagtgaa ttgtaatacg     2940

actcactata gggcgaattg ggcccgacgt cgcatgctcc cggccgccat ggccgcggga     3000

ttcgcggatc cgccaatgtt ggtgaagtca ctgtttttag tgaccatttt gtgtgcacta     3060

tgtagtgcaa atttgtttga ttctgataat aattatgtgt actactacca aagtgctttt     3120

agaccgccaa atgggtggca cttacaagga ggtgcttatg cagtagtcag ttctactaat     3180

tatactaata atgccggttc tgcacatggg tgcactgttg gtgttattaa ggatgtttat     3240

aatcaaagtg tggcttccat agctatgaca gcacctcttc agggtatggc ttggtctaag     3300

tcacaattct gtagtgcaca ctgtaatttt tctgaaatta cagtttttgt cacacattgt     3360

tatagtagtg gtagtgggtc gtgtcctata acaggcatga ttccacgtga tcatattcgt     3420

atttctgcaa tgaaaaatgg ttccttattt tataatttaa cagttagcgt atctaaatac     3480

cctaatttta aatcttttca atgtgttaac aacttcacat ctgtttattt aaatggtgat     3540

cttgttttta cttccaacaa aactactgat gttacgtcag caggtgtgta ttttaaagca     3600

ggtggacctg taaattatag tattatgaaa gaatttaagg ttcttgctta ttttgttaat     3660

ggtacagcac aagatgtagt tttgtgcgac aattccccca agggtttgct agcttgtcaa     3720

tataacactg gcaatttttc agatggcttt tatcctttta ctaatagtac tttggttagg     3780

gaaaagttca tcgtctatcg tgaaagtagt gttaatacta cttgtgcgtt aactaatttt     3840

acttttagta atgtaagtaa tgcacagcct aatagtggtg gtgttaatac ttttcattta     3900

tatcaaacac aaacagctca gagtggttat tataatttta atttgtcatt tctgagtcag     3960

tttgtgtata aggcaagtga ttttatgtat gggtcctacc atcctagttg ttcttttaga     4020

ccagaaacca ttaatagtgg tttatggttt aattccttgt cagtttctct tacctatgga     4080

cccctacagg gagggtgtaa gcaatctgtt tttagtggta aggcaacgtg ttgttacgcc     4140

tactcttata gaggcccaat ggcatgtaaa ggtgtttatt caggtgaatt aagcacgaat     4200

tttgaatgtg gattgctggt ttatgttact aagagtgatg gctctcgtat acagactaga     4260

acagagccct tagtattaac gcaatacaat tataataata ttactttaga taagtgtgtt     4320

gcctataata tatatggcag agtgggccaa ggttttatta ctaatgtgac tgattctgct     4380

gctaatttta gttatttagc agatggtggg ttagctattt tagatacgtc gggtgccata     4440

gatgtttttg ttgtacaggg catctatggc cttaattatt acaaggtcaa tccttgtgaa     4500

gatgttaacc aacaatttgt agtgtctggt ggcaatatag ttggcattct tacttctaga     4560

aatgaaacag gttctgaaca ggttgagaac cagttttatg ttaagttaac caatagctca     4620

catcgtcgta agcgttctat tggccaaaac gtaacaagtt gtccttatgt tagctatggc     4680

agattttgta ttgaaccaga tggttcgtta aagatgatag tgccagaaga attgaaacag     4740

tttgtggcac ctttacttaa tattactgaa agtgtactca tacctaacag ttttaatctt     4800

actgttacag atgagtacat acaaacacgt atggataagg tccaaatcaa ttgccttcaa     4860

tatgtttgcg gcaattcttt ggagtgtaga aaattgtttc aacaatatgg tccggtttgt     4920

gataatatat tgtctgttgt aaatagtgtt agtcaaaaag aagatatgga acttttaagc     4980

ttctattcct ctactaaacc aaagggttat gatacaccag ttcttagtaa tgtaagcact     5040

ggtgaattta atatttctct tctcttgaaa cccccaagca gtcctagtgg gcgttctttc     5100

attgaagagc ttttatttac aagtgttgaa acagttggtt tgccaactga tgctgaatat     5160

aaaaaatgca cagcgggacc tttgggtact cttaaagatc ttatctgtgc tagggaatat     5220

aatggtttat tagtgttgcc tccaattatt acggcggata tgcaaacaat gtatactgct     5280

tctttagtgg gtgctatggc ctttggtggt attacatcag ctgcagctat accttttgct     5340

actcagattc aggcaagaat taatcatctt ggtattacac agtctttgtt aatgaaaaat     5400

caagaaaaga ttgctgcttc ctttaataag gccattggtc atatgcagga aggttttaga     5460

agcacttctc tagcattaca acagattcaa gatgttgtta ataagcagag tgctattctt     5520

actgaaacta tgaattctct taataagaat tttggtgcta ttacatcagt cattcaagat     5580

atttacgcgc aacttgacgc aatccaagca gatgcacaag ttgaccgcct tattactggt     5640

agactttcat cactctcagt gttagcctct gctaaacagt ctgagtatat tagagtttcc     5700

cagcagcgtg aattagccac tcaaaaaatt aatgagtgtg ttaaatcaca atctaatagg     5760

tacggatttt gtggtagtgg aagacatgtt ctttcgatac cacaaaatgc acctaatggt     5820

atagtgttta tacactttac ttatacacca gagagttttg ttaatgttac tgcaatagtg     5880

ggtttttgtg taaatcctgc taatgctagt cagtatgcta tagtacctgc taatggaagg     5940

ggtattttta tacaagttaa tggcacgtac tatatcactg cacgtgatat gtatatgcca     6000

cgagacatta ctgcaggaga tatagttact cttacgtctt gtcaagcaaa ttatgttaat     6060

gtaaataaaa ccgtcattac tacatttgta gaagatgacg attttgattt tgatgatgag     6120

ttgtcaaaat ggtggaatga tactaagcat cagctaccag actttgacga cttcaattac     6180

acagtaccca tacttaatat tagcggtgaa attgattata ttcaaggtgt tatacagggt     6240

cttaatgact cccttataga ccttgaagaa ctttcaataa ttaaaactta tattaagtgg     6300

ccttggtatg tttggcttgc catattcttt gccattatta tctttatcct tatattagga     6360

tgggttttct tcatgactgg atgttgtggt tgttgttgtg ggtgctttgg cattattcct     6420

ctaatgagta agtgtggtaa gaaatcttct tactacacta cttttgataa tgatgtggta     6480

acttaacaat acagacctaa aaagtctgtt taacggccgc cgc                       6523


<210>  67
<211>  11320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid Sequence

<400>  67
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt ggagatcggt acttcgcgaa      420

tgcgtcgaga tgagctctaa tacgactcac tatagggact taagtgtgat ataaatatat      480

atcatacata ctagccttgt gctagatttc caacttaaca aaacggactt aaatacctac      540

agttggtccc tataggtgtt ccattgcagt gcactttagt gccctggatg gcacctggcc      600

acctgtcagg tttttgttat taaaataata ttgttgctgg tatcactgct tgttttgccg      660

tgtctcactt tatacatccg ttgcttgggc tacctagtat ccagcgtcct actggcgttg      720

tggtcggttc gagtgcgaag aacctctggt tcatctagcg gtacgcgggt gtgtggaagt      780

agcgcttcag acgtaccggt tctgttgcgt gaaatacggg gtcacctccc cccacatacc      840

tctaagggct tttgagccta gcgttgggct acgttctcgc acaaggtcgg ctatacggcg      900

tttgtagggg gtagtgccaa acaacccctg aggtgacagg ttctggtggt gtttcgaaaa      960

caacaatgtg tgtgccgcat aatatgcgag taatgcattt tggagcagga agtgacaaag     1020

gagtggcccc aggtagcgct gttcttaggc agtggcttcc cgaaggtaca ctccttgtcg     1080

ataatgatat tgtagattat gtatctgatg cacatgtctc tgtgctttca gattgcaata     1140

aatgtaaaac agagcacaag tttgatcttg tgatatctga tatgtataca gataatgatt     1200

caaagagaaa gcatgaaggc gttgtagcca ataacggcaa tgatgacgtc ttcatatacc     1260

tttcaaactt tcttcgtaac aatttagctc tgggaggcag ttttgccgta aaagtaacag     1320

agacaagttg gcatgagagt ttatatgaca ttgcacagga ttgtgcatgg tggacaatgt     1380

tttgtacagc agtgaatgct tcttcgtcag aagcattctt gattggtgtt aattatttgg     1440

gtgcaagtga aaaggttaga gttagtggta aaaccctgca cgcaaattat atattttgga     1500

ggaattgtaa ttatttacaa acttcagcct atagtatatt tgacgttgct aagtttgatt     1560

tgaaattaaa agcaacgcca gttgtgaatt tgaaaactga acaaaagaca gacttagtct     1620

ttaatttaat taagtgtggt aagttactgg taagagatgt tggacaaacc gcttttacta     1680

gtgactcttt ggtatgcact atgtagtgct ttgctctatg ataataatac ttacgtttac     1740

tactaccaaa gtgcctttag gcctggtcca ggttggcacc tatatggggg tgcttatgca     1800

gtagataggg tttttaatga aaccaacaat gcaggcagtg catctgattg cactgctggt     1860

actttttatg aaagccataa tatttctgct tcttctgtag ccatgacagt accacataat     1920

ggtatgtctt ggtcagcttc acaattttgt acagctcatt gtaacttctc agactttaca     1980

gtgttcgtta cgcattgttt taaaaatcaa ctcggtagtt gtcccttgac aggtatgatt     2040

cctcagaatc atattcgtat ttctgctatg agagatggag ttttgtttta taacttaaca     2100

gttagcgtat ctaaataccc tagatttaaa tcgcttcaat gtgttagcaa ttctacatct     2160

gtctatgtaa atggtgacct tgttttcact tctaatgaaa cttcttacgt tacgggtgca     2220

ggcgtttatt ttaaaagtgg tgggcctgta acttataaag ttatgaaaga agttaaagcc     2280

ctagcctact ttattaatgg taccgcacaa gaggttattt tatgtgataa ctcacctaga     2340

ggtttgcttg catgtcagta taacactggt aatttttcag atggattcta cccttttact     2400

aatcattctt tagttaagga taggtttatt gtatatcgag aaagtagcac taacactact     2460

ttaaagttaa ctaatttcag ttttactaat gtaagtaatg cttctcctaa ttcaggtggc     2520

gttgatactt tccaattata tcaaacaagt actgctcagg atggttatta taattttaat     2580

ttatcatttc tgagtagttt tgtgtataaa ccatctgatt ttatgtatgg gtcataccac     2640

ccacattgta agtttagacc agagaatatt aataatggct tatggtttaa ttcattatct     2700

gtgtcactta cttacggacc cattcaaggt ggttgtaagc aatctgtttt tagtaataga     2760

gcaacttgtt gctatgctta ttcttatcaa gggcctagta gatgtaaggg tgtttataga     2820

ggggagctaa cgcaatactt tgaatgtgga cttctagttt acgtaactaa gagtgatggc     2880

tctcgtatac aaactagaag tgaaccactg gtgttaactc aatataatta taacaacatt     2940

actttaaata agtgtgttga gtataatata tatggtaggg ttggtcaagg ttttattact     3000

aatgtaactg aagcaactgc taattatagt tatctagcag atggtggttt agctatttta     3060

gatacctcag gagccataga catatttgtt gttcaaggtg catatggtct taattattat     3120

aaggttaatc cctgtgaaga tgttaaccaa cagtttgtag tgtctggtgg caacttagtt     3180

ggcattctta catctcataa tgaaacaggt tctgaatcta ttgagaacca gttttacatc     3240

aaactcacta acggaacacg tcgctctaga cgttctgtta ctgggaatgt tacaaattgc     3300

ccttatgtta gttatggcaa gttttgtata aaaccagatg gttctttatc tataatagta     3360

ccacaagaat tagaacagtt tgtggcgcct ttattcaatg ttactgagca tgtgctcata     3420

cctgatagtt ttaatttaac tgtcacagat gagtacatac aaactcgtat ggataaggtt     3480

caaattattt gccttcagta tgtttgtggt aattctattg aatgcagaaa gttgtttcag     3540

cagtatggac ctgtttgtga taatatattg tctgttgtaa atggtgtagg tcaaagagag     3600

gatatggaac ttttaagttt ctattcttct actaaaccta gtggttacaa tacaccaatt     3660

tttaataatg ttagcactgg tgactttaat atttcgctcc tactaacacc acctaatagt     3720

cctactgggc gctcttttat tgaagatctt ctctttacaa gtgtagaatc tgttggatta     3780

ccaactgatg aagagtataa aaagtgtaca gcaggacctt taggttttgt taaagacctt     3840

gtttgtgcta gagagtataa tggtttgctc gttctgcctc ctattattac tgcggaaatg     3900

caaaccatgt atactagttc tttagtagcc tctatggctt taggtggcat tactgcagct     3960

ggtgctatac cttttgctac acaactgcag gccagaatta accatttggg tattactaat     4020

tctcttttgt tgaaaaacca agaaaaaatt gctgcttcct ttaataaggc catcggtcat     4080

atgcaggaag ggtttaaaag tacttctcta gcattacaac agattcaaga tgttgttaat     4140

aaacagagtt ctattcttac agagactatg caatcactta ataaaaattt tggtgctatt     4200

tcctctgtaa ttcaagacat ttaccagcaa ctagatgcta ttcaggcaga tgctcaggtt     4260

gatcgtctta ttacaggtag actctcttca ctatctgttt tagcttctgc taaacaggca     4320

gagtatcata gagtgtcaca acagcgtgag ttggccactc agaaaattaa tgagtgtgtt     4380

aagtctcagt ctaataggta ttcattttgt ggtaatggta gacatgttct aaccatacca     4440

cagaatgcac ccaatggcat agtgtttata cactttacat acactccaga gagttttgtt     4500

aatgttacgg caatagtagg gttttgcgta aacccagcta atgctagtca ttatgcaata     4560

gtgcctgtta atggcagggg tgtttttata gaagttaatg gtagttacta tatcactgct     4620

cgtgatatgt atatgccaag agatattact gcaggagaca tagtcacttt gacttcttgt     4680

caagcaaact atgttaatgt aaataaaacc gtcattaaca cttttgtgga agatgacgat     4740

tttgattttt atgatgaatt gtcaaaatgg tggaatgata ctaagcatga gctaccagat     4800

tttgatgaat tcaattatac cgttccagtt ttaaatatta gtaatgaaat tgacagaatt     4860

caacaggtta ttcagggatt aaatgattcc ctaatagacc ttgaaacact ctcaattctc     4920

aaaacttata ttaaatggcc ttggtatgtg tggcttgcca ttgcattcct taccattatt     4980

tttattctgg tactttgttg gatatttttc atgaccggtt gttgcggttg ttgttgtgga     5040

tgctttggta tcataccgtt aatgagtaag tgtggtaaga aatcttctta ctacacgact     5100

tttgataatg atgtggtaac ttaacaatac agacctaaaa agtctgttta atgattaaaa     5160

gtcccacatc ttttctaata ttattaattc ttctttggtg taaacttgca ttaagttgtt     5220

ttaaagagtg tgttataaca ctccagcaac tagtacaaat tttactccaa attattaata     5280

gtaacttaca atctagactt ctgctttggc acagtctaga ctaatgttag attttgaagc     5340

aattattgaa actggtcagc aaataactca acaaattagt ttctatttac agcatatttc     5400

aagggtgcta agtactgaat tatttgaccc ctttgaagtt tgtgtttaca gaggaggtaa     5460

ttgttgggag ttagagtcag ctgacgagtt ttcaggtgat gacgaatata ttgagtagat     5520

cgctcgagga gaacggaagt tttctaacag cggtttacgt gtttttagga tttttagcac     5580

tttatctact aggtagagcg cttcaagctt ttgtacaagc ggctgacgct tgttgtcttt     5640

tttggtatac atgggtagta gttcctggag ccaagggcac agcctttgtt tataatcata     5700

catatggtaa aaaacttaac aaaccggagt tagaaacggt tattgttaac gaatttccaa     5760

aaaacggttg gaaatatgga taataccatc aattgtactc ttggtactga acaagcagtt     5820

cagcttttta aggaatataa tctgtttgta actgcattcc tgttgttttt aaccatacta     5880

cttcagtatg gatacgcaac taggagcaag gttatttaca tactgaaaat gatagtgtta     5940

tggtgctttt ggccccttaa cattgcagta ggtgtaatct catgtatata cccaccaaac     6000

acaggaggtc ttgtcgcagc gataattctt acagtgtttg cgtgtctttc ttttataggt     6060

tattggatcc agagtattag actttttaag cggtgcaggt catggtggtc atttaacccc     6120

gaatctaatg ccgtaggttc aatactccta actaatggtc aacaatgtaa ttttgctata     6180

gagagtgtgc cgatggtgct ttctcctatt ataaagaatg gtgctcttta ttgcgagggt     6240

cagtggcttg ctaaatgtga accagaccac ttgcctagag atatatttgt atgcacaccg     6300

gatagacgta atatctatcg tatggtgcaa aaatatactg gtgaccaaag cggaagtaag     6360

aaaaggtttg ccacatttgt ctatgcaaag cagtcagtag atactggcga gctagaaagt     6420

gtgtcagcag taggaggtag tctttacaca taaatgtgtg tgtgtagaga gtatttaaaa     6480

ttattctttg acagtgcctc cgttttaaga gcgcggaaga gtattatttt tgaggatatt     6540

aatataaatc ctctttgttt catactctcc tttcaggagt tattatttaa aaaacagttt     6600

ttccactctt ttgtgccaaa aacaattgtt gttaatggtg taacctttca ggtagacaat     6660

ggaaaagtct actacgaagg aagaccaatt ttccaaaaag gttgttgtag tttgtggtcc     6720

aattataaga aagattagaa taattaaacc acctacaaca cttattttta caaatggcgt     6780

tttaggttac aaacgcttaa caaatacgga tgatgaaatg gctgactagt tttggaagag     6840

ctttcatctc ctgttataaa tccctattac taactcaatt aagagtatta gataggttaa     6900

ttttagatca cggacccaag cgcacattaa cgtgtgctag gcgagtgctt ttagttcaat     6960

tagatttagt ttataggttg gcttatacgc ccacccaatc gctggtatga ataatagtaa     7020

agataatcct tttcgcggag caatagcaag aaaagcgcga atttatctga gaggaggatt     7080

agattgtgtt tactttctta acaaagcagg acaagcagag ccttgtcccg cgtgtacctc     7140

cctagtattc caagggaaaa cttgtgagga acactattat aataacaatc ttttgtcatg     7200

gcaagcggta aggcaactgg aaagacagac gccccagcgc cagtcatcaa actaggagga     7260

ccaaagccac ctaaagttgg ttcttctgga aatgcatcat ggtttcaacc gataaaggcc     7320

aagaagctaa attcacctgt gcctaaattt gacggtagtg gtgttcctga aaatgaaaat     7380

ctcaagtcaa gccagcaaca tggatactgg agacgccaac acaggtttaa gcctggcaaa     7440

ggtggaagaa aaccagtccc tgatgcttgg tacttttact acactggaac aggaccggcc     7500

gccgacctga attggggtga aactcaagat ggtatagtgt gggttgctgc aaagggtgct     7560

gatactaaat ctagatcaaa ccagggtaca agggatcctg ataagtttga ccaataccca     7620

ctacgattct cagatggagg accggatggt aatttccgtt gggacttcat accaataaat     7680

cgtggtagga gtgggagatc aacagcagct tcatcagcag catctagtag agcaccatct     7740

cgtgaggggt cacgtggacg tagaagcgga gttgaagatg atcttatagc tcgcgcagca     7800

aagattatac aggaccagca aaagaagggt gcgcgcatta ccaaggctaa ggctgatgaa     7860

atggctcatc gccgctattg caagcgcact atcccacctg gttataaggt tgagcaagta     7920

tttggtcccc gtactaaagg taaggaagga aattttggtg atgacaagat gaatgaggaa     7980

ggtgttaagg atgggcgtgt tacggcaatg ctcaacctag tccctagcag tcatgcttgt     8040

ctttttggaa gtagggtgac gcccaaactg cagccagatg gtcttcacct gagatttgaa     8100

tttactactg tggtgtcacg tgatgatccg cagtttgata attatgtgaa aatttgtgat     8160

cagtgtgtcg atggtgtagg gacgcgtcca aaggacgatg aatcgagacc aaagtcacgc     8220

ccaaattcaa gacctgcaac tagaggaaat tctccagcgc cgagacaaca gcgcccaaag     8280

aaggagaaaa agcccaagaa gcaggatgat gaagtagata aggcattgac ctcagatgag     8340

gagaggaaca atgcacagct ggaatttgat gatgaaccca aggtgattaa ctggggggac     8400

tctgcactag gtgaaaatga actttgatta acataatgga cttgctgcat ttgctgtcac     8460

attttgttaa atattatttt tgtgttttac tatcaattat tacaggtatt gattgtgatt     8520

atgttcaata cttaagcttc ttctggttgc tttttgcttg ttgtattgtt gctgtgcttt     8580

ttattattgt gattctcatt agtttgcttt atcgtagaaa ttcaatagta agagttaagg     8640

aagataggca tgtagcttag cacctacatg tctatcgcca gggaaatgtc taatctgtct     8700

acttagtagc ctggaaacga acggtagacc cttagatttt aatttagttt aatttttagt     8760

ttagtttaag ttagtttaga gtaggtataa agatgccagt gccggggcca cgcgtagtac     8820

gaccgagggt acagcactag gacgcccact aggggaagag ctaaatttta gtttaagtta     8880

agtttaattg gctaaatata gttaaaattt ataggctagt atagagttag agcaaaaaaa     8940

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     9000

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaagcggccg catcggatgc cgggaccgac     9060

gagtgcagag gcgtgcaagc gagcttggcg taatcatggt catagctgtt tcctgtgtga     9120

aattgttatc cgctcacaat tccacacaac atacgagccg gaagcataaa gtgtaaagcc     9180

tggggtgcct aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc     9240

cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc     9300

ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt     9360

cggctgcggc gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca     9420

ggggataacg caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa     9480

aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat     9540

cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc     9600

cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc     9660

gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt     9720

tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac     9780

cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg     9840

ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca     9900

gagttcttga agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc     9960

gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa    10020

accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa    10080

ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac    10140

tcacgttaag ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta    10200

aattaaaaat gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt    10260

taccaatgct taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata    10320

gttgcctgac tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc    10380

agtgctgcaa tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac    10440

cagccagccg gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag    10500

tctattaatt gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac    10560

gttgttgcca ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc    10620

agctccggtt cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg    10680

gttagctcct tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc    10740

atggttatgg cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct    10800

gtgactggtg agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc    10860

tcttgcccgg cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc    10920

atcattggaa aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc    10980

agttcgatgt aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc    11040

gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca    11100

cggaaatgtt gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt    11160

tattgtctca tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt    11220

ccgcgcacat ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca    11280

ttaacctata aaaataggcg tatcacgagg ccctttcgtc                          11320


<210>  68
<211>  11323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid Sequence

<400>  68
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt ggagatcggt acttcgcgaa      420

tgcgtcgaga tgagctctaa tacgactcac tatagggact taagtgtgat ataaatatat      480

atcatacata ctagccttgt gctagatttc caacttaaca aaacggactt aaatacctac      540

agttggtccc tataggtgtt ccattgcagt gcactttagt gccctggatg gcacctggcc      600

acctgtcagg tttttgttat taaaataata ttgttgctgg tatcactgct tgttttgccg      660

tgtctcactt tatacatccg ttgcttgggc tacctagtat ccagcgtcct actggcgttg      720

tggtcggttc gagtgcgaag aacctctggt tcatctagcg gtacgcgggt gtgtggaagt      780

agcgcttcag acgtaccggt tctgttgcgt gaaatacggg gtcacctccc cccacatacc      840

tctaagggct tttgagccta gcgttgggct acgttctcgc acaaggtcgg ctatacggcg      900

tttgtagggg gtagtgccaa acaacccctg aggtgacagg ttctggtggt gtttcgaaaa      960

caacaatgtg tgtgccgcat aatatgcgag taatgcattt tggagcagga agtgacaaag     1020

gagtggcccc aggtagcgct gttcttaggc agtggcttcc cgaaggtaca ctccttgtcg     1080

ataatgatat tgtagattat gtatctgatg cacatgtctc tgtgctttca gattgcaata     1140

aatgtaaaac agagcacaag tttgatcttg tgatatctga tatgtataca gataatgatt     1200

caaagagaaa gcatgaaggc gttgtagcca ataacggcaa tgatgacgtc ttcatatacc     1260

tttcaaactt tcttcgtaac aatttagctc tgggaggcag ttttgccgta aaagtaacag     1320

agacaagttg gcatgagagt ttatatgaca ttgcacagga ttgtgcatgg tggacaatgt     1380

tttgtacagc agtgaatgct tcttcgtcag aagcattctt gattggtgtt aattatttgg     1440

gtgcaagtga aaaggttaga gttagtggta aaaccctgca cgcaaattat atattttgga     1500

ggaattgtaa ttatttacaa acttcagcct atagtatatt tgacgttgct aagtttgatt     1560

tgaaattaaa agcaacgcca gttgtgaatt tgaaaactga acaaaagaca gacttagtct     1620

ttaatttaat taagtgtggt aagttactgg taagagatgt tggtgaagtc actgttttta     1680

gtgaccattt tgtgtgcact atgtagtgca aatttgtttg attctgataa taattatgtg     1740

tactactacc aaagtgcttt tagaccgcca aatgggtggc acttacaagg aggtgcttat     1800

gcagtagtca gttctactaa ttatactaat aatgccggtt ctgcacatgg gtgcactgtt     1860

ggtgttatta aggatgttta taatcaaagt gtggcttcca tagctatgac agcacctctt     1920

cagggtatgg cttggtctaa gtcacaattc tgtagtgcac actgtaattt ttctgaaatt     1980

acagtttttg tcacacattg ttatagtagt ggtagtgggt cgtgtcctat aacaggcatg     2040

attccacgtg atcatattcg tatttctgca atgaaaaatg gttccttatt ttataattta     2100

acagttagcg tatctaaata ccctaatttt aaatcttttc aatgtgttaa caacttcaca     2160

tctgtttatt taaatggtga tcttgttttt acttccaaca aaactactga tgttacgtca     2220

gcaggtgtgt attttaaagc aggtggacct gtaaattata gtattatgaa agaatttaag     2280

gttcttgctt attttgttaa tggtacagca caagatgtag ttttgtgcga caattccccc     2340

aagggtttgc tagcttgtca atataacact ggcaattttt cagatggctt ttatcctttt     2400

actaatagta ctttggttag ggaaaagttc atcgtctatc gtgaaagtag tgttaatact     2460

acttgtgcgt taactaattt tacttttagt aatgtaagta atgcacagcc taatagtggt     2520

ggtgttaata cttttcattt atatcaaaca caaacagctc agagtggtta ttataatttt     2580

aatttgtcat ttctgagtca gtttgtgtat aaggcaagtg attttatgta tgggtcctac     2640

catcctagtt gttcttttag accagaaacc attaatagtg gtttatggtt taattccttg     2700

tcagtttctc ttacctatgg acccctacag ggagggtgta agcaatctgt ttttagtggt     2760

aaggcaacgt gttgttacgc ctactcttat agaggcccaa tggcatgtaa aggtgtttat     2820

tcaggtgaat taagcacgaa ttttgaatgt ggattgctgg tttatgttac taagagtgat     2880

ggctctcgta tacagactag aacagagccc ttagtattaa cgcaatacaa ttataataat     2940

attactttag ataagtgtgt tgcctataat atatatggca gagtgggcca aggttttatt     3000

actaatgtga ctgattctgc tgctaatttt agttatttag cagatggtgg gttagctatt     3060

ttagatacgt cgggtgccat agatgttttt gttgtacagg gcatctatgg ccttaattat     3120

tacaaggtca atccttgtga agatgttaac caacaatttg tagtgtctgg tggcaatata     3180

gttggcattc ttacttctag aaatgaaaca ggttctgaac aggttgagaa ccagttttat     3240

gttaagttaa ccaatagctc acatcgtcgt aagcgttcta ttggccaaaa cgtaacaagt     3300

tgtccttatg ttagctatgg cagattttgt attgaaccag atggttcgtt aaagatgata     3360

gtgccagaag aattgaaaca gtttgtggca cctttactta atattactga aagtgtactc     3420

atacctaaca gttttaatct tactgttaca gatgagtaca tacaaacacg tatggataag     3480

gtccaaatca attgccttca atatgtttgc ggcaattctt tggagtgtag aaaattgttt     3540

caacaatatg gtccggtttg tgataatata ttgtctgttg taaatagtgt tagtcaaaaa     3600

gaagatatgg aacttttaag cttctattcc tctactaaac caaagggtta tgatacacca     3660

gttcttagta atgtaagcac tggtgaattt aatatttctc ttctcttgaa acccccaagc     3720

agtcctagtg ggcgttcttt cattgaagag cttttattta caagtgttga aacagttggt     3780

ttgccaactg atgctgaata taaaaaatgc acagcgggac ctttgggtac tcttaaagat     3840

cttatctgtg ctagggaata taatggttta ttagtgttgc ctccaattat tacggcggat     3900

atgcaaacaa tgtatactgc ttctttagtg ggtgctatgg cctttggtgg tattacatca     3960

gctgcagcta taccttttgc tactcagatt caggcaagaa ttaatcatct tggtattaca     4020

cagtctttgt taatgaaaaa tcaagaaaag attgctgctt cctttaataa ggccattggt     4080

catatgcagg aaggttttag aagcacttct ctagcattac aacagattca agatgttgtt     4140

aataagcaga gtgctattct tactgaaact atgaattctc ttaataagaa ttttggtgct     4200

attacatcag tcattcaaga tatttacgcg caacttgacg caatccaagc agatgcacaa     4260

gttgaccgcc ttattactgg tagactttca tcactctcag tgttagcctc tgctaaacag     4320

tctgagtata ttagagtttc ccagcagcgt gaattagcca ctcaaaaaat taatgagtgt     4380

gttaaatcac aatctaatag gtacggattt tgtggtagtg gaagacatgt tctttcgata     4440

ccacaaaatg cacctaatgg tatagtgttt atacacttta cttatacacc agagagtttt     4500

gttaatgtta ctgcaatagt gggtttttgt gtaaatcctg ctaatgctag tcagtatgct     4560

atagtacctg ctaatggaag gggtattttt atacaagtta atggcacgta ctatatcact     4620

gcacgtgata tgtatatgcc acgagacatt actgcaggag atatagttac tcttacgtct     4680

tgtcaagcaa attatgttaa tgtaaataaa accgtcatta ctacatttgt agaagatgac     4740

gattttgatt ttgatgatga gttgtcaaaa tggtggaatg atactaagca tcagctacca     4800

gactttgacg acttcaatta cacagtaccc atacttaata ttagcggtga aattgattat     4860

attcaaggtg ttatacaggg tcttaatgac tcccttatag accttgaaga actttcaata     4920

attaaaactt atattaagtg gccttggtat gtttggcttg ccatattctt tgccattatt     4980

atctttatcc ttatattagg atgggttttc ttcatgactg gatgttgtgg ttgttgttgt     5040

gggtgctttg gcattattcc tctaatgagt aagtgtggta agaaatcttc ttactacact     5100

acttttgata atgatgtggt aacttaacaa tacagaccta aaaagtctgt ttaatgatta     5160

aaagtcccac atcttttcta atattattaa ttcttctttg gtgtaaactt gcattaagtt     5220

gttttaaaga gtgtgttata acactccagc aactagtaca aattttactc caaattatta     5280

atagtaactt acaatctaga cttctgcttt ggcacagtct agactaatgt tagattttga     5340

agcaattatt gaaactggtc agcaaataac tcaacaaatt agtttctatt tacagcatat     5400

ttcaagggtg ctaagtactg aattatttga cccctttgaa gtttgtgttt acagaggagg     5460

taattgttgg gagttagagt cagctgacga gttttcaggt gatgacgaat atattgagta     5520

gatcgctcga ggagaacgga agttttctaa cagcggttta cgtgttttta ggatttttag     5580

cactttatct actaggtaga gcgcttcaag cttttgtaca agcggctgac gcttgttgtc     5640

ttttttggta tacatgggta gtagttcctg gagccaaggg cacagccttt gtttataatc     5700

atacatatgg taaaaaactt aacaaaccgg agttagaaac ggttattgtt aacgaatttc     5760

caaaaaacgg ttggaaatat ggataatacc atcaattgta ctcttggtac tgaacaagca     5820

gttcagcttt ttaaggaata taatctgttt gtaactgcat tcctgttgtt tttaaccata     5880

ctacttcagt atggatacgc aactaggagc aaggttattt acatactgaa aatgatagtg     5940

ttatggtgct tttggcccct taacattgca gtaggtgtaa tctcatgtat atacccacca     6000

aacacaggag gtcttgtcgc agcgataatt cttacagtgt ttgcgtgtct ttcttttata     6060

ggttattgga tccagagtat tagacttttt aagcggtgca ggtcatggtg gtcatttaac     6120

cccgaatcta atgccgtagg ttcaatactc ctaactaatg gtcaacaatg taattttgct     6180

atagagagtg tgccgatggt gctttctcct attataaaga atggtgctct ttattgcgag     6240

ggtcagtggc ttgctaaatg tgaaccagac cacttgccta gagatatatt tgtatgcaca     6300

ccggatagac gtaatatcta tcgtatggtg caaaaatata ctggtgacca aagcggaagt     6360

aagaaaaggt ttgccacatt tgtctatgca aagcagtcag tagatactgg cgagctagaa     6420

agtgtgtcag cagtaggagg tagtctttac acataaatgt gtgtgtgtag agagtattta     6480

aaattattct ttgacagtgc ctccgtttta agagcgcgga agagtattat ttttgaggat     6540

attaatataa atcctctttg tttcatactc tcctttcagg agttattatt taaaaaacag     6600

tttttccact cttttgtgcc aaaaacaatt gttgttaatg gtgtaacctt tcaggtagac     6660

aatggaaaag tctactacga aggaagacca attttccaaa aaggttgttg tagtttgtgg     6720

tccaattata agaaagatta gaataattaa accacctaca acacttattt ttacaaatgg     6780

cgttttaggt tacaaacgct taacaaatac ggatgatgaa atggctgact agttttggaa     6840

gagctttcat ctcctgttat aaatccctat tactaactca attaagagta ttagataggt     6900

taattttaga tcacggaccc aagcgcacat taacgtgtgc taggcgagtg cttttagttc     6960

aattagattt agtttatagg ttggcttata cgcccaccca atcgctggta tgaataatag     7020

taaagataat ccttttcgcg gagcaatagc aagaaaagcg cgaatttatc tgagaggagg     7080

attagattgt gtttactttc ttaacaaagc aggacaagca gagccttgtc ccgcgtgtac     7140

ctccctagta ttccaaggga aaacttgtga ggaacactat tataataaca atcttttgtc     7200

atggcaagcg gtaaggcaac tggaaagaca gacgccccag cgccagtcat caaactagga     7260

ggaccaaagc cacctaaagt tggttcttct ggaaatgcat catggtttca accgataaag     7320

gccaagaagc taaattcacc tgtgcctaaa tttgacggta gtggtgttcc tgaaaatgaa     7380

aatctcaagt caagccagca acatggatac tggagacgcc aacacaggtt taagcctggc     7440

aaaggtggaa gaaaaccagt ccctgatgct tggtactttt actacactgg aacaggaccg     7500

gccgccgacc tgaattgggg tgaaactcaa gatggtatag tgtgggttgc tgcaaagggt     7560

gctgatacta aatctagatc aaaccagggt acaagggatc ctgataagtt tgaccaatac     7620

ccactacgat tctcagatgg aggaccggat ggtaatttcc gttgggactt cataccaata     7680

aatcgtggta ggagtgggag atcaacagca gcttcatcag cagcatctag tagagcacca     7740

tctcgtgagg ggtcacgtgg acgtagaagc ggagttgaag atgatcttat agctcgcgca     7800

gcaaagatta tacaggacca gcaaaagaag ggtgcgcgca ttaccaaggc taaggctgat     7860

gaaatggctc atcgccgcta ttgcaagcgc actatcccac ctggttataa ggttgagcaa     7920

gtatttggtc cccgtactaa aggtaaggaa ggaaattttg gtgatgacaa gatgaatgag     7980

gaaggtgtta aggatgggcg tgttacggca atgctcaacc tagtccctag cagtcatgct     8040

tgtctttttg gaagtagggt gacgcccaaa ctgcagccag atggtcttca cctgagattt     8100

gaatttacta ctgtggtgtc acgtgatgat ccgcagtttg ataattatgt gaaaatttgt     8160

gatcagtgtg tcgatggtgt agggacgcgt ccaaaggacg atgaatcgag accaaagtca     8220

cgcccaaatt caagacctgc aactagagga aattctccag cgccgagaca acagcgccca     8280

aagaaggaga aaaagcccaa gaagcaggat gatgaagtag ataaggcatt gacctcagat     8340

gaggagagga acaatgcaca gctggaattt gatgatgaac ccaaggtgat taactggggg     8400

gactctgcac taggtgaaaa tgaactttga ttaacataat ggacttgctg catttgctgt     8460

cacattttgt taaatattat ttttgtgttt tactatcaat tattacaggt attgattgtg     8520

attatgttca atacttaagc ttcttctggt tgctttttgc ttgttgtatt gttgctgtgc     8580

tttttattat tgtgattctc attagtttgc tttatcgtag aaattcaata gtaagagtta     8640

aggaagatag gcatgtagct tagcacctac atgtctatcg ccagggaaat gtctaatctg     8700

tctacttagt agcctggaaa cgaacggtag acccttagat tttaatttag tttaattttt     8760

agtttagttt aagttagttt agagtaggta taaagatgcc agtgccgggg ccacgcgtag     8820

tacgaccgag ggtacagcac taggacgccc actaggggaa gagctaaatt ttagtttaag     8880

ttaagtttaa ttggctaaat atagttaaaa tttataggct agtatagagt tagagcaaaa     8940

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     9000

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaagcgg ccgcatcgga tgccgggacc     9060

gacgagtgca gaggcgtgca agcgagcttg gcgtaatcat ggtcatagct gtttcctgtg     9120

tgaaattgtt atccgctcac aattccacac aacatacgag ccggaagcat aaagtgtaaa     9180

gcctggggtg cctaatgagt gagctaactc acattaattg cgttgcgctc actgcccgct     9240

ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa tcggccaacg cgcggggaga     9300

ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc     9360

gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa     9420

tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     9480

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     9540

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     9600

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     9660

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     9720

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     9780

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     9840

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     9900

acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc     9960

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa    10020

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa    10080

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa    10140

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt    10200

ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac    10260

agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc    10320

atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt accatctggc    10380

cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata    10440

aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc    10500

cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc    10560

aacgttgttg ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca    10620

ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa    10680

gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca    10740

ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt    10800

tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt    10860

tgctcttgcc cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg    10920

ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga    10980

tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc    11040

agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg    11100

acacggaaat gttgaatact catactcttc ctttttcaat attattgaag catttatcag    11160

ggttattgtc tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg    11220

gttccgcgca catttccccg aaaagtgcca cctgacgtct aagaaaccat tattatcatg    11280

acattaacct ataaaaatag gcgtatcacg aggccctttc gtc                      11323


<210>  69
<211>  11407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vector sequence

<400>  69
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt ggagatcggt acttcgcgaa      420

tgcgtcgaga tcggccgccc gggtaatacg actcactata gggacttaag atagatatta      480

atatatatct attgcactag ccttgcgcta gatttcaaac ttaacaaaac ggacttaaat      540

acctacagct ggtccccata ggtgttccat tgcagtgcac tttagtgccc tggatggcac      600

ctggccacct gtcaggtttt tgttgttaaa atatcattgt tgctggtatc actgcttgtt      660

ttgccgtgtc tcactttata catccgttgc ttgggctacc tagtatccag cgtcctacgg      720

gcgccgtggt cggttcgagt gcgaaggacc tctggttcat ctagcggtag gcgggtgtgt      780

ggaagtagcg cttcagacgt actggttctg ttgcgtgaaa cgcggggtca cctcccccca      840

catacctcta agggcttttg agcctagcgt tgggctacgt tctcgcacaa ggtcggctat      900

acgacgtttg tagggggtag tgccaaacaa cccctgaggt gacaggttct ggtggtgttt      960

cgaaaacaac aatgtgtgtg ccgcataata tgcgcgttat gcattttgga gcaggtagtg     1020

ataaaggagt ggcgcctggt agtactgttc ttaaacagtg gctccccgaa ggaacactcc     1080

ttgtcgataa tgatattgta gattatgttt ctgacgcaca cgtttctgtg ctttcagatt     1140

gcaataaata taagacagag cacaagtttg atcttgtgat atctgatatg tatacagaca     1200

atgattcaaa aagaaagcat gaaggcgtga tagccaataa tggcaatgat gacgtcttca     1260

tatacctttc aagttttcta cgcaataatt tggctctggg aggcagtttt gctgtaaaat     1320

taacagagac aagttggcat gagagtttat atgacattgc acaggattgt gcatggtgga     1380

caatgttttg tacagcagtg aatgcatctt cttcagaagc attcctgatt ggtgttaatt     1440

acttgggtgc aagtgcaaag gttaaagtta gtggaaaaac actgcacgca aattatatat     1500

tttggaggaa ttgtaattat ttacaaacct ctgcttatag tatatttgat gttgctaagt     1560

ttgatttgag attgaaagca acgccagttg ttaatcttaa gactgaacaa aagacagact     1620

tagtctttaa tttgataaag tgtggtaagt tactggtaag agatgttggt gaagtcactg     1680

tttttagtga ccattttgtg tgcactatgt agtgcaaatt tgtttgattc tgataataat     1740

tatgtgtact actaccaaag tgcttttaga ccgccaaatg ggtggcactt acaaggaggt     1800

gcttatgcag tagtcagttc tactaattat actaataatg ccggttctgc acatgggtgc     1860

actgttggtg ttattaagga tgtttataat caaagtgtgg cttccatagc tatgacagca     1920

cctcttcagg gtatggcttg gtctaagtca caattctgta gtgcacactg taatttttct     1980

gaaattacag tttttgtcac acattgttat agtagtggta gtgggtcgtg tcctataaca     2040

ggcatgattc cacgtgatca tattcgtatt tctgcaatga aaaatggttc cttattttat     2100

aatttaacag ttagcgtatc taaataccct aattttaaat cttttcaatg tgttaacaac     2160

ttcacatctg tttatttaaa tggtgatctt gtttttactt ccaacaaaac tactgatgtt     2220

acgtcagcag gtgtgtattt taaagcaggt ggacctgtaa attatagtat tatgaaagaa     2280

tttaaggttc ttgcttattt tgttaatggt acagcacaag atgtagtttt gtgcgacaat     2340

tcccccaagg gtttgctagc ttgtcaatat aacactggca atttttcaga tggcttttat     2400

ccttttacta atagtacttt ggttagggaa aagttcatcg tctatcgtga aagtagtgtt     2460

aatactactt gtgcgttaac taattttact tttagtaatg taagtaatgc acagcctaat     2520

agtggtggtg ttaatacttt tcatttatat caaacacaaa cagctcagag tggttattat     2580

aattttaatt tgtcatttct gagtcagttt gtgtataagg caagtgattt tatgtatggg     2640

tcctaccatc ctagttgttc ttttagacca gaaaccatta atagtggttt atggtttaat     2700

tccttgtcag tttctcttac ctatggaccc ctacagggag ggtgtaagca atctgttttt     2760

agtggtaagg caacgtgttg ttacgcctac tcttatagag gcccaatggc atgtaaaggt     2820

gtttattcag gtgaattaag cacgaatttt gaatgtggat tgctggttta tgttactaag     2880

agtgatggct ctcgtataca gactagaaca gagcccttag tattaacgca atacaattat     2940

aataatatta ctttagataa gtgtgttgcc tataatatat atggcagagt gggccaaggt     3000

tttattacta atgtgactga ttctgctgct aattttagtt atttagcaga tggtgggtta     3060

gctattttag atacgtcggg tgccatagat gtttttgttg tacagggcat ctatggcctt     3120

aattattaca aggtcaatcc ttgtgaagat gttaaccaac aatttgtagt gtctggtggc     3180

aatatagttg gcattcttac ttctagaaat gaaacaggtt ctgaacaggt tgagaaccag     3240

ttttatgtta agttaaccaa tagctcacat cgtcgtaagc gttctattgg ccaaaacgta     3300

acaagttgtc cttatgttag ctatggcaga ttttgtattg aaccagatgg ttcgttaaag     3360

atgatagtgc cagaagaatt gaaacagttt gtggcacctt tacttaatat tactgaaagt     3420

gtactcatac ctaacagttt taatcttact gttacagatg agtacataca aacacgtatg     3480

gataaggtcc aaatcaattg ccttcaatat gtttgcggca attctttgga gtgtagaaaa     3540

ttgtttcaac aatatggtcc ggtttgtgat aatatattgt ctgttgtaaa tagtgttagt     3600

caaaaagaag atatggaact tttaagcttc tattcctcta ctaaaccaaa gggttatgat     3660

acaccagttc ttagtaatgt aagcactggt gaatttaata tttctcttct cttgaaaccc     3720

ccaagcagtc ctagtgggcg ttctttcatt gaagagcttt tatttacaag tgttgaaaca     3780

gttggtttgc caactgatgc tgaatataaa aaatgcacag cgggaccttt gggtactctt     3840

aaagatctta tctgtgctag ggaatataat ggtttattag tgttgcctcc aattattacg     3900

gcggatatgc aaacaatgta tactgcttct ttagtgggtg ctatggcctt tggtggtatt     3960

acatcagctg cagctatacc ttttgctact cagattcagg caagaattaa tcatcttggt     4020

attacacagt ctttgttaat gaaaaatcaa gaaaagattg ctgcttcctt taataaggcc     4080

attggtcata tgcaggaagg ttttagaagc acttctctag cattacaaca gattcaagat     4140

gttgttaata agcagagtgc tattcttact gaaactatga attctcttaa taagaatttt     4200

ggtgctatta catcagtcat tcaagatatt tacgcgcaac ttgacgcaat ccaagcagat     4260

gcacaagttg accgccttat tactggtaga ctttcatcac tctcagtgtt agcctctgct     4320

aaacagtctg agtatattag agtttcccag cagcgtgaat tagccactca aaaaattaat     4380

gagtgtgtta aatcacaatc taataggtac ggattttgtg gtagtggaag acatgttctt     4440

tcgataccac aaaatgcacc taatggtata gtgtttatac actttactta tacaccagag     4500

agttttgtta atgttactgc aatagtgggt ttttgtgtaa atcctgctaa tgctagtcag     4560

tatgctatag tacctgctaa tggaaggggt atttttatac aagttaatgg cacgtactat     4620

atcactgcac gtgatatgta tatgccacga gacattactg caggagatat agttactctt     4680

acgtcttgtc aagcaaatta tgttaatgta aataaaaccg tcattactac atttgtagaa     4740

gatgacgatt ttgattttga tgatgagttg tcaaaatggt ggaatgatac taagcatcag     4800

ctaccagact ttgacgactt caattacaca gtacccatac ttaatattag cggtgaaatt     4860

gattatattc aaggtgttat acagggtctt aatgactccc ttatagacct tgaagaactt     4920

tcaataatta aaacttatat taagtggcct tggtatgttt ggcttgccat attctttgcc     4980

attattatct ttatccttat attaggatgg gttttcttca tgactggatg ttgtggttgt     5040

tgttgtgggt gctttggcat tattcctcta atgagtaagt gtggtaagaa atcttcttac     5100

tacactactt ttgataatga tgtggtaact taacaataca gacctaaaaa gtctgtttaa     5160

tgatccaaag tcccactagt ttcttaatag tattaatttt gctttggtgt aaacttgtac     5220

taagttgttt tagagagttt attattgccc ttcaacaact aacacaagtt ttactccaaa     5280

ttatcgatag taatttacag tctagactga ccctttggca cagtctagac taatgttaaa     5340

cttagaagca attattgaaa ccggtgatca agtgattcaa aaaatcagtt tcaatttaca     5400

gcatatttca agtgtattaa acacagaagt atttgacccc tttgactatt gttattacag     5460

aggaggtaat ttttgggaaa tagagtcagc tgaagattgt tcaggtgatg atgaatttat     5520

tgaataagtc gctagaggag aatggaagtt ttctaacggc actttacata tttgtaggat     5580

ttttagcatt ttatcttcta ggtagagcac ttcaagcatt tgtacaggct gctgatgctt     5640

gttgtttatt ttggtacacg tggttagtaa ttccaggagt taagggtaca gcctttgtat     5700

acaagtatac atatggtaga aaacttaaca attcggaatt agaagcagtt gttgttaacg     5760

agtttcctaa gaacggttgg aataataaaa atccagcaaa ttttcaagat gtccaacgaa     5820

acaaattgta ctcttgactt tgaacagtca gttgagcttt ttaaagagta taatttattt     5880

ataactgcat tcttgttgtt cttaaccata atacttcagt atggttatgc aacgcgtagt     5940

aagtttattt atatacttaa aatgatagtg ttatggtgct tttggcccct taacattgca     6000

gtaggtgtaa tttcatgtat atacccacca aacacaggag gtcttgtcgc agcgataata     6060

cttactgtgt ttgcgtgtct ttcttttgta ggttattgga tccagagtat tagactcttt     6120

aagcggtgta gatcttggtg gtcatttaac ccagaatcta acgccgtagg ttcaatactc     6180

ctaactaatg gtcaacaatg taattttgct atagagagtg tgccgatggt gctttctcct     6240

attataaaga atggtgttct ttattgtgag ggtcagtggc ttgctaaatg tgaaccagac     6300

cacttgccta aagacatatt tgtatgcaca ccagatagac gtaatatcta tcgtatggtg     6360

cagaaataca ctggtgacca aagcggaaat aagaaaaggt ttgctacatt tgtctatgca     6420

aagcagtcag tagacactgg cgagctagaa agtgtagcaa caggtggaag tagcctttac     6480

acataaatgt gtgtgtgtag agagtattta aaattattct tcaatagtgc ctctatttta     6540

agagcgcgga agagtatttg ttttgaggat attaatataa atcctctttg ttttgtactc     6600

tctttacaag agttattatt taagcaacag tttttccttt cctttgtttg gaagaaagtt     6660

gttgttaatg gtgtagaatt ccaagtagaa aatggaaaag tccactacga aggaaacccc     6720

attttccaaa aaggttgttg taggttgtgg tcccattata agaaggatta aatggattaa     6780

accacctaca ctacttactt gtaataaggg cgtttggact tacaagcgct taacaaatac     6840

agacgatgaa atggctgact agttttggaa gagcagttat ttcttgttat aaagccctac     6900

tattaactca gttaagagta ttagataggt taattttaga tcacggacca aagcgagtct     6960

taacgtgtgg taggcgagtg cttttatctc aattagattt agtttatagg ttggcatata     7020

cgcccaccca atcgctggta tgaataatag taaagataat ccttttcgcg gagcaatagc     7080

aagaaaagcg cgaatttatc tgagagaagg attagagtgt gtttactttc ttaacaaagc     7140

aggacaagca gagccttgtc ccgcgtgtac ctccctagta tttcagggga aaacttgtga     7200

ggaacacaca gataataata atcttttgtc atggcgagcg gtaagacaac tgggaagaca     7260

gacgccccag cgccagtcat caaactagga gggccaaaac cacctaaagt tggttcttct     7320

ggaaatgcta gctggtttca agcactaaaa gccaagaagt taaattcacc tcctcctaag     7380

tttgaaggta gcggcgttcc tgataatgaa aatcttaaat taagccagca acatgggtac     7440

tggagacgtc aagccaggta caagccaggt aaaggcggaa gaaaatcagt cccagatgct     7500

tggtacttct attacactgg aacaggacca gccgctgacc tgaattgggg tgatagccaa     7560

gatggtatag tgtgggtttc tgcaaagggt gctgatacta aatctagatc taaccagggt     7620

acaagggatc ctgataagtt tgaccaatac ccgctacgat tctcagatgg aggacctgat     7680

ggtaatttcc gttgggactt cattccaata aatcgtggta ggagtggaag atcaacagcg     7740

gcttcatcag cagcatctag tagagcaccg tcgcgtgatg gctcgcgtgg acgtagaagc     7800

ggagctgaag atgatcttat agctcgtgca gcaaagatca ttcaggatca gcagaagaag     7860

ggttctcgca ttactaaagc taaggccgat gaaatggctc atcgccggta ttgtaagcgt     7920

actatcccac ctggttataa ggttgatcaa gtatttggtc cccgtactaa aggtaaggag     7980

ggaaattttg gtgatgacaa gatgaatgag gagggtatta aggatgggcg cgttacagca     8040

atgctcaacc tagtccctag cagccatgct tgtctttttg gaagtagagt gacgcccaaa     8100

cttcaaccag atgggctgca cttgagattt gaatttacta ctgtggtttc tagggatgat     8160

ccgcagtttg ataattatgt gaaaatttgt gatcagtgtg tcgatggtgt agggactcgg     8220

ccaaaagacg atgaaccgag accaaagtca cgcccaaatt caagacctgc tacaagaaca     8280

agttctccag cgccaagaca acagcgtcaa aagaaggaga agaagtcaaa gaagcaggat     8340

gatgaagtag ataaggcatt gacctcagat gaggagagga acaatgcaca gctggaattt     8400

gatgatgaac cgaaagtgat taactggggg gattcagcac ttggagagaa tgagttgtaa     8460

agctagattt ccaacttaac atcatggacg tgcgtatgct gtttttccct actatagact     8520

ttttagcata ttattttttg ctatttgtat ggtttattac aggtgaagat tgtatgtatt     8580

tgttgtacac tcgtatgttc tatattatgt tttctgtagt tgttattagt gttgttcttg     8640

ttcttactct actgttctct tttctttatt ttagagtatc aataagaatc aaggaagata     8700

ggcatgtagt ttgattacct acatgtctat cgccagggaa atgtctaatc tgtctactta     8760

gtagcctgga aacgaacggt agacccttag attttaattt agtttaattt ttagtttagt     8820

ttaagttagt ttagagtagg tataaagaag ccagtgccgg ggccacgcgg agtacgatcg     8880

agggtacagc actaggacgc ccactagggg aagagctaaa ttttagttta agttaagttt     8940

aattggctaa gtatagttaa aatttatagg ctagtataga gttagagcaa aaaaaaaaaa     9000

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     9060

aaaaaaaaaa aaaaaaaaaa aaaaaaaagt ttaaacttaa ttaagaattc ccttggctcg     9120

agttcgaaat cggatgccgg gaccgacgag tgcagaggcg tgcaagcgag cttggcgtaa     9180

tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata     9240

cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta actcacatta     9300

attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa     9360

tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc cgcttcctcg     9420

ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag     9480

gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat gtgagcaaaa     9540

ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc     9600

cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca     9660

ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg     9720

accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct     9780

catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt     9840

gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag     9900

tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc     9960

agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac    10020

actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga    10080

gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc    10140

aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg    10200

gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca    10260

aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt    10320

atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca    10380

gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta gataactacg    10440

atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga cccacgctca    10500

ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt    10560

cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt    10620

agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca    10680

cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag gcgagttaca    10740

tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat cgttgtcaga    10800

agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa ttctcttact    10860

gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa gtcattctga    10920

gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga taataccgcg    10980

ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg gcgaaaactc    11040

tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc acccaactga    11100

tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg aaggcaaaat    11160

gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact cttccttttt    11220

caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt    11280

atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgac    11340

gtctaagaaa ccattattat catgacatta acctataaaa ataggcgtat cacgaggccc    11400

tttcgtc                                                              11407


<210>  70
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  70
cagagcacaa gtttgatctt gtgatatctg atatgtatac agacaatgat tc               52


<210>  71
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  71
acttcaccaa catctcttac cagtaactta cc                                     32


<210>  72
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  72
ttactggtaa gagatgttgg tgaagtcact g                                      31


<210>  73
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  73
ggactttgga tcattaaaca gactttttag gtctg                                  35


<210>  74
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  74
aaagtctgtt taatgatcca aagtcccact ag                                     32


<210>  75
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  75
cttaactcct ggaattacta accacgtgta ccaaaataaa caacaagc                    48


<210>  76
<211>  1168
<212>  PRT
<213>  Avian infectious bronchitis virus

<400>  76

Met Leu Val Lys Ser Leu Phe Leu Val Thr Ile Leu Phe Ala Leu Cys 
1               5                   10                  15      


Ser Ala Asn Leu Tyr Asp Asn Glu Ser Phe Val Tyr Tyr Tyr Gln Ser 
            20                  25                  30          


Ala Phe Arg Pro Gly His Gly Trp His Leu His Gly Gly Ala Tyr Ala 
        35                  40                  45              


Val Val Asn Val Ser Ser Glu Asn Asn Asn Ala Gly Thr Ala Pro Ser 
    50                  55                  60                  


Cys Thr Ala Gly Ala Ile Gly Tyr Ser Lys Asn Leu Ser Ala Ala Ser 
65                  70                  75                  80  


Val Ala Met Thr Ala Pro Leu Ser Gly Met Ser Trp Ser Ala Asn Ser 
                85                  90                  95      


Phe Cys Thr Ala His Cys Asn Phe Thr Ser Tyr Ile Val Phe Val Thr 
            100                 105                 110         


His Cys Tyr Lys Ser Gly Ser Asn Ser Cys Pro Leu Thr Gly Leu Ile 
        115                 120                 125             


Pro Ser Gly Tyr Ile Arg Ile Ala Ala Met Lys His Gly Ser Ala Met 
    130                 135                 140                 


Pro Gly His Leu Phe Tyr Asn Leu Thr Val Ser Val Thr Lys Tyr Pro 
145                 150                 155                 160 


Lys Phe Arg Ser Leu Gln Cys Val Asn Asn Tyr Thr Ser Val Tyr Leu 
                165                 170                 175     


Asn Gly Asp Leu Val Phe Thr Ser Asn Tyr Thr Glu Asp Val Val Ala 
            180                 185                 190         


Ala Gly Val His Phe Lys Ser Gly Gly Pro Ile Thr Tyr Lys Val Met 
        195                 200                 205             


Arg Glu Val Lys Ala Leu Ala Tyr Phe Val Asn Gly Thr Ala His Asp 
    210                 215                 220                 


Val Ile Leu Cys Asp Asp Thr Pro Arg Gly Leu Leu Ala Cys Gln Tyr 
225                 230                 235                 240 


Asn Thr Gly Asn Phe Ser Asp Gly Phe Tyr Pro Phe Thr Asn Thr Ser 
                245                 250                 255     


Ile Val Lys Asp Lys Phe Ile Val Tyr Arg Glu Ser Ser Val Asn Thr 
            260                 265                 270         


Thr Leu Thr Leu Thr Asn Phe Thr Phe Ser Asn Glu Ser Gly Ala Pro 
        275                 280                 285             


Pro Asn Thr Gly Gly Val Asp Ser Phe Ile Leu Tyr Gln Thr Gln Thr 
    290                 295                 300                 


Ala Gln Ser Gly Tyr Tyr Asn Phe Asn Phe Ser Phe Leu Ser Ser Phe 
305                 310                 315                 320 


Val Tyr Arg Glu Ser Asn Tyr Met Tyr Gly Ser Tyr His Pro Arg Cys 
                325                 330                 335     


Ser Phe Arg Pro Glu Thr Leu Asn Gly Leu Trp Phe Asn Ser Leu Ser 
            340                 345                 350         


Val Ser Leu Thr Tyr Gly Pro Ile Gln Gly Gly Cys Lys Gln Ser Val 
        355                 360                 365             


Phe Asn Gly Lys Ala Thr Cys Cys Tyr Ala Tyr Ser Tyr Gly Gly Pro 
    370                 375                 380                 


Arg Gly Cys Lys Gly Val Tyr Arg Gly Glu Leu Thr Gln His Phe Glu 
385                 390                 395                 400 


Cys Gly Leu Leu Val Tyr Val Thr Lys Ser Asp Gly Ser Arg Ile Gln 
                405                 410                 415     


Thr Ala Thr Gln Pro Pro Val Leu Thr Gln Asn Phe Tyr Asn Asn Ile 
            420                 425                 430         


Asn Leu Gly Lys Cys Val Asp Tyr Asn Ile Tyr Gly Arg Ile Gly Gln 
        435                 440                 445             


Gly Leu Ile Thr Asn Val Thr Asp Leu Ala Val Ser Tyr Asn Tyr Leu 
    450                 455                 460                 


Ser Asp Ala Gly Leu Ala Ile Leu Asp Thr Ser Gly Ala Ile Asp Ile 
465                 470                 475                 480 


Phe Val Val Gln Gly Glu Tyr Gly Pro Asn Tyr Tyr Lys Val Asn Pro 
                485                 490                 495     


Cys Glu Asp Val Asn Gln Gln Phe Val Val Ser Gly Gly Lys Leu Val 
            500                 505                 510         


Gly Ile Leu Thr Ser Arg Asn Glu Thr Gly Ser Gln Leu Leu Glu Asn 
        515                 520                 525             


Gln Phe Tyr Ile Lys Ile Thr Asn Gly Thr Arg Arg Ser Arg Arg Ser 
    530                 535                 540                 


Val Thr Glu Asn Val Thr Asn Cys Pro Tyr Val Ser Tyr Gly Lys Phe 
545                 550                 555                 560 


Cys Ile Lys Pro Asp Gly Ser Ile Ser Val Ile Val Pro Lys Glu Leu 
                565                 570                 575     


Asp Gln Phe Val Ala Pro Leu Leu Asn Val Thr Glu Tyr Val Leu Ile 
            580                 585                 590         


Pro Asn Ser Phe Asn Leu Thr Val Thr Asp Glu Tyr Ile Gln Thr Arg 
        595                 600                 605             


Met Asp Lys Ile Gln Ile Asn Cys Leu Gln Tyr Val Cys Gly Asn Ser 
    610                 615                 620                 


Leu Ala Cys Arg Lys Leu Phe Gln Gln Tyr Gly Pro Val Cys Asp Asn 
625                 630                 635                 640 


Ile Leu Ser Val Val Asn Ser Val Gly Gln Lys Glu Asp Met Glu Leu 
                645                 650                 655     


Leu Asn Phe Tyr Ser Ser Thr Lys Pro Ala Arg Phe Asn Thr Pro Val 
            660                 665                 670         


Phe Ser Asn Leu Ser Thr Gly Glu Phe Asn Ile Ser Leu Leu Leu Thr 
        675                 680                 685             


Ser Pro Ser Ser Pro Arg Arg Arg Ser Phe Ile Glu Asp Leu Leu Phe 
    690                 695                 700                 


Thr Ser Val Glu Ser Val Gly Leu Pro Thr Asp Asp Ala Tyr Lys Lys 
705                 710                 715                 720 


Cys Thr Ala Gly Pro Leu Gly Phe Phe Lys Asp Leu Ala Cys Ala Arg 
                725                 730                 735     


Glu Tyr Asn Gly Leu Leu Val Leu Pro Pro Ile Ile Thr Ala Glu Met 
            740                 745                 750         


Gln Thr Leu Tyr Thr Ser Ser Leu Val Ala Ser Met Ala Phe Gly Gly 
        755                 760                 765             


Ile Thr Ala Ala Gly Ala Ile Pro Phe Ala Thr Gln Leu Gln Ala Arg 
    770                 775                 780                 


Ile Asn His Leu Gly Ile Thr Gln Ser Leu Leu Leu Lys Asn Gln Glu 
785                 790                 795                 800 


Lys Ile Ala Ala Ser Phe Asn Lys Ala Ile Gly His Met Gln Glu Gly 
                805                 810                 815     


Phe Arg Ser Thr Ser Leu Ala Leu Gln Gln Ile Gln Asp Val Val Asn 
            820                 825                 830         


Lys Gln Ser Ala Ile Leu Thr Glu Thr Met Ala Ala Leu Asn Lys Asn 
        835                 840                 845             


Phe Gly Ala Ile Ser Ser Val Ile Gln Asp Ile Tyr Gln Gln Leu Asp 
    850                 855                 860                 


Ser Ile Gln Ala Asp Ala Gln Val Asp Arg Leu Ile Thr Gly Arg Leu 
865                 870                 875                 880 


Ser Ser Leu Ser Val Leu Ala Ser Ala Lys Gln Ser Glu Tyr Ile Arg 
                885                 890                 895     


Val Ser Gln Gln Arg Glu Leu Ala Thr Gln Lys Ile Asn Glu Cys Val 
            900                 905                 910         


Lys Ser Gln Ser Ile Arg Tyr Ser Phe Cys Gly Asn Gly Arg His Val 
        915                 920                 925             


Leu Thr Ile Pro Gln Asn Ala Pro Asn Gly Ile Val Phe Ile His Phe 
    930                 935                 940                 


Thr Tyr Thr Pro Glu Ser Phe Ile Asn Val Thr Ala Ile Val Gly Phe 
945                 950                 955                 960 


Cys Val Ser Pro Ala Asn Ala Ser Gln Tyr Ala Ile Val Pro Ala Asn 
                965                 970                 975     


Gly Arg Gly Ile Phe Ile Gln Val Asn Gly Ser Tyr Tyr Ile Thr Ala 
            980                 985                 990         


Arg Asp Met Tyr Met Pro Arg Asp  Ile Thr Ala Gly Asp  Ile Val Thr 
        995                 1000                 1005             


Leu Thr  Ser Cys Gln Ala Asn  Tyr Val Ser Val Asn  Lys Thr Val 
    1010                 1015                 1020             


Ile Thr  Thr Phe Val Asp Asn  Asp Asp Phe Asp Phe  Asp Asp Glu 
    1025                 1030                 1035             


Leu Ser  Lys Trp Trp Asn Asp  Thr Lys His Glu Leu  Pro Asp Phe 
    1040                 1045                 1050             


Asp Lys  Phe Asn Tyr Thr Val  Pro Ile Leu Asp Ile  Asp Ser Glu 
    1055                 1060                 1065             


Ile Asp  Arg Ile Gln Gly Val  Ile Gln Gly Leu Asn  Asp Ser Leu 
    1070                 1075                 1080             


Ile Asp  Leu Glu Thr Leu Ser  Ile Leu Lys Thr Tyr  Ile Lys Trp 
    1085                 1090                 1095             


Pro Trp  Tyr Val Trp Leu Ala  Ile Ala Phe Ala Thr  Ile Ile Phe 
    1100                 1105                 1110             


Ile Leu  Ile Leu Gly Trp Leu  Phe Phe Met Thr Gly  Cys Cys Gly 
    1115                 1120                 1125             


Cys Cys  Cys Gly Cys Phe Gly  Ile Ile Pro Leu Met  Ser Lys Cys 
    1130                 1135                 1140             


Gly Lys  Lys Ser Ser Tyr Tyr  Thr Thr Phe Asp Asn  Asp Val Val 
    1145                 1150                 1155             


Thr Glu  Gln Tyr Arg Pro Lys  Lys Ser Val 
    1160                 1165             


<210>  77
<211>  1168
<212>  PRT
<213>  Avian infectious bronchitis virus

<400>  77

Met Leu Val Lys Ser Leu Phe Leu Val Thr Ile Leu Phe Ala Leu Cys 
1               5                   10                  15      


Ser Ala Asn Leu Tyr Asp Asn Glu Ser Phe Val Tyr Tyr Tyr Gln Ser 
            20                  25                  30          


Ala Phe Arg Pro Gly His Gly Trp His Leu His Gly Gly Ala Tyr Ala 
        35                  40                  45              


Val Val Asn Val Ser Ser Glu Asn Asn Asn Ala Gly Thr Ala Pro Ser 
    50                  55                  60                  


Cys Thr Ala Gly Ala Ile Gly Tyr Ser Lys Asn Leu Ser Ala Ala Ser 
65                  70                  75                  80  


Val Ala Met Thr Ala Pro Leu Ser Gly Met Ser Trp Ser Ala Asn Ser 
                85                  90                  95      


Phe Cys Thr Ala His Cys Asn Phe Thr Ser Tyr Ile Val Phe Val Thr 
            100                 105                 110         


His Cys Tyr Lys Ser Gly Ser Asn Ser Cys Pro Leu Thr Gly Leu Ile 
        115                 120                 125             


Pro Ser Gly Tyr Ile Arg Ile Ala Ala Met Lys His Gly Ser Ala Met 
    130                 135                 140                 


Pro Gly His Leu Phe Tyr Asn Leu Thr Val Ser Val Thr Lys Tyr Pro 
145                 150                 155                 160 


Lys Phe Arg Ser Leu Gln Cys Val Asn Asn Tyr Thr Ser Val Tyr Leu 
                165                 170                 175     


Asn Gly Asp Leu Val Phe Thr Ser Asn Tyr Thr Glu Asp Val Val Ala 
            180                 185                 190         


Ala Gly Val His Phe Lys Ser Gly Gly Pro Ile Thr Tyr Lys Val Met 
        195                 200                 205             


Arg Glu Val Lys Ala Leu Ala Tyr Phe Val Asn Gly Thr Ala His Asp 
    210                 215                 220                 


Val Ile Leu Cys Asp Asp Thr Pro Arg Gly Leu Leu Ala Cys Gln Tyr 
225                 230                 235                 240 


Asn Thr Gly Asn Phe Ser Asp Gly Phe Tyr Pro Phe Thr Asn Thr Ser 
                245                 250                 255     


Ile Val Lys Asp Lys Phe Ile Val Tyr Arg Glu Ser Ser Val Asn Thr 
            260                 265                 270         


Thr Cys Thr Leu Thr Asn Phe Thr Phe Ser Asn Glu Ser Gly Ala Pro 
        275                 280                 285             


Pro Asn Thr Gly Gly Val Asp Ser Phe Ile Leu Tyr Gln Thr Gln Thr 
    290                 295                 300                 


Ala Gln Ser Gly Tyr Tyr Asn Phe Asn Phe Ser Phe Leu Ser Ser Phe 
305                 310                 315                 320 


Val Tyr Arg Glu Ser Asn Tyr Met Tyr Gly Ser Tyr His Pro Arg Cys 
                325                 330                 335     


Ser Phe Arg Pro Glu Thr Leu Asn Gly Leu Trp Phe Asn Ser Leu Ser 
            340                 345                 350         


Val Ser Leu Thr Tyr Gly Pro Ile Gln Gly Gly Cys Lys Gln Ser Val 
        355                 360                 365             


Phe Asn Gly Lys Ala Thr Cys Cys Tyr Ala Tyr Ser Tyr Gly Gly Pro 
    370                 375                 380                 


Arg Gly Cys Lys Gly Val Tyr Arg Gly Glu Leu Thr Gln His Phe Glu 
385                 390                 395                 400 


Cys Gly Leu Leu Val Tyr Val Thr Lys Ser Asp Gly Ser Arg Ile Gln 
                405                 410                 415     


Thr Ala Thr Gln Pro Pro Val Leu Thr Gln Asn Phe Tyr Asn Asn Ile 
            420                 425                 430         


Asn Leu Gly Lys Cys Val Asp Tyr Asn Ile Tyr Gly Arg Ile Gly Gln 
        435                 440                 445             


Gly Leu Ile Thr Asn Val Thr Asp Leu Ala Val Ser Tyr Asn Tyr Leu 
    450                 455                 460                 


Ser Asp Ala Gly Leu Ala Ile Leu Asp Thr Ser Gly Ala Ile Asp Ile 
465                 470                 475                 480 


Phe Val Val Gln Gly Glu Tyr Gly Pro Asn Tyr Tyr Lys Val Asn Pro 
                485                 490                 495     


Cys Glu Asp Val Asn Gln Gln Phe Val Val Ser Gly Gly Lys Leu Val 
            500                 505                 510         


Gly Ile Leu Thr Ser Arg Asn Glu Thr Gly Ser Gln Leu Leu Glu Asn 
        515                 520                 525             


Gln Phe Tyr Ile Lys Ile Thr Asn Gly Thr Arg Arg Ser Arg Arg Ser 
    530                 535                 540                 


Val Thr Glu Asn Val Thr Asn Cys Pro Tyr Val Ser Tyr Gly Lys Phe 
545                 550                 555                 560 


Cys Ile Lys Pro Asp Gly Ser Ile Ser Val Ile Val Pro Lys Glu Leu 
                565                 570                 575     


Asp Gln Phe Val Ala Pro Leu Leu Asn Val Thr Glu Tyr Val Leu Ile 
            580                 585                 590         


Pro Asn Ser Phe Asn Leu Thr Val Thr Asp Glu Tyr Ile Gln Thr Arg 
        595                 600                 605             


Met Asp Lys Ile Gln Ile Asn Cys Leu Gln Tyr Val Cys Gly Asn Ser 
    610                 615                 620                 


Leu Ala Cys Arg Lys Leu Phe Gln Gln Tyr Gly Pro Val Cys Asp Asn 
625                 630                 635                 640 


Ile Leu Ser Val Val Asn Ser Val Gly Gln Lys Glu Asp Met Glu Leu 
                645                 650                 655     


Leu Asn Phe Tyr Ser Ser Thr Lys Pro Ala Arg Phe Asn Thr Pro Val 
            660                 665                 670         


Phe Ser Asn Leu Ser Thr Gly Glu Phe Asn Ile Ser Leu Leu Leu Thr 
        675                 680                 685             


Ser Pro Ser Ser Pro Arg Arg Arg Ser Phe Ile Glu Asp Leu Leu Phe 
    690                 695                 700                 


Thr Ser Val Glu Ser Val Gly Leu Pro Thr Asp Asp Ala Tyr Lys Lys 
705                 710                 715                 720 


Cys Thr Ala Gly Pro Leu Gly Phe Phe Lys Asp Leu Ala Cys Ala Arg 
                725                 730                 735     


Glu Tyr Asn Gly Leu Leu Val Leu Pro Pro Ile Ile Thr Ala Glu Met 
            740                 745                 750         


Gln Thr Leu Tyr Thr Ser Ser Leu Val Ala Ser Met Ala Phe Gly Gly 
        755                 760                 765             


Ile Thr Ala Ala Gly Ala Ile Pro Phe Ala Thr Gln Leu Gln Ala Arg 
    770                 775                 780                 


Ile Asn His Leu Gly Ile Thr Gln Ser Leu Leu Leu Lys Asn Gln Glu 
785                 790                 795                 800 


Lys Ile Ala Ala Ser Phe Asn Lys Ala Ile Gly His Met Gln Glu Gly 
                805                 810                 815     


Phe Arg Ser Thr Ser Leu Ala Leu Gln Gln Ile Gln Asp Val Val Asn 
            820                 825                 830         


Lys Gln Ser Ala Ile Leu Thr Glu Thr Met Ala Ala Leu Asn Lys Asn 
        835                 840                 845             


Phe Gly Ala Ile Ser Ser Val Ile Gln Asp Ile Tyr Gln Gln Leu Asp 
    850                 855                 860                 


Ser Ile Gln Ala Asp Ala Gln Val Asp Arg Leu Ile Thr Gly Arg Leu 
865                 870                 875                 880 


Ser Ser Leu Ser Val Leu Ala Ser Ala Lys Gln Ser Glu Tyr Ile Arg 
                885                 890                 895     


Val Ser Gln Gln Arg Glu Leu Ala Thr Gln Lys Ile Asn Glu Cys Val 
            900                 905                 910         


Lys Ser Gln Ser Ile Arg Tyr Ser Phe Cys Gly Asn Gly Arg His Val 
        915                 920                 925             


Leu Thr Ile Pro Gln Asn Ala Pro Asn Gly Ile Val Phe Ile His Phe 
    930                 935                 940                 


Thr Tyr Thr Pro Glu Ser Phe Ile Asn Val Thr Ala Ile Val Gly Phe 
945                 950                 955                 960 


Cys Val Ser Pro Ala Asn Ala Ser Gln Tyr Ala Ile Val Pro Ala Asn 
                965                 970                 975     


Gly Arg Gly Ile Phe Ile Gln Val Asn Gly Ser Tyr Tyr Ile Thr Ala 
            980                 985                 990         


Arg Asp Met Tyr Met Pro Arg Asp  Ile Thr Ala Gly Asp  Ile Val Thr 
        995                 1000                 1005             


Leu Thr  Ser Cys Gln Ala Asn  Tyr Val Ser Val Asn  Lys Thr Val 
    1010                 1015                 1020             


Ile Thr  Thr Phe Val Asp Asn  Asp Asp Phe Asp Phe  Asp Asp Glu 
    1025                 1030                 1035             


Leu Ser  Lys Trp Trp Asn Asp  Thr Lys His Glu Leu  Pro Asp Phe 
    1040                 1045                 1050             


Asp Lys  Phe Asn Tyr Thr Val  Pro Ile Leu Asp Ile  Asp Ser Glu 
    1055                 1060                 1065             


Ile Asp  Arg Ile Gln Gly Val  Ile Gln Gly Leu Asn  Asp Ser Leu 
    1070                 1075                 1080             


Ile Asp  Leu Glu Thr Leu Ser  Ile Leu Lys Thr Tyr  Ile Lys Trp 
    1085                 1090                 1095             


Pro Trp  Tyr Val Trp Leu Ala  Ile Ala Phe Ala Thr  Ile Ile Phe 
    1100                 1105                 1110             


Ile Leu  Ile Leu Gly Trp Leu  Phe Phe Met Thr Gly  Cys Cys Gly 
    1115                 1120                 1125             


Cys Cys  Cys Gly Cys Phe Gly  Ile Ile Pro Leu Met  Ser Lys Cys 
    1130                 1135                 1140             


Gly Lys  Lys Ser Ser Tyr Tyr  Thr Thr Phe Asp Asn  Asp Val Val 
    1145                 1150                 1155             


Thr Glu  Gln Tyr Arg Pro Lys  Lys Ser Val 
    1160                 1165             


<210>  78
<211>  6217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  78
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cgagctcggt acctcgcgaa      420

tgcatctaga tatgttggtg aagtcactgt ttctagtgac cattttgttt gcactatgta      480

gtgctaattt atatgacaac gaatcttttg tgtattacta ccagagtgct tttaggccag      540

gacatggttg gcatttacat ggaggtgctt atgcagtagt taatgtgtct agtgaaaata      600

ataatgcagg tactgcccca agttgcactg ctggtgctat tggctacagt aagaatctca      660

gtgcggcctc agtagccatg actgcaccac taagtggtat gtcatggtct gccaactctt      720

tttgtacagc ccactgtaat tttacttctt atatagtgtt tgttacacat tgttataaga      780

gcggatctaa tagttgtcct ttgacaggtc ttattccaag cggttatatt cgtattgctg      840

ctatgaaaca tggaagtgct atgcctggtc acttatttta taatttaaca gtttctgtga      900

ctaaatatcc taagtttaga tcgctacaat gtgttaataa ttatacttct gtatatttaa      960

atggtgacct tgttttcaca tctaactata ctgaagatgt tgtagctgca ggtgtccatt     1020

ttaaaagtgg tggacctata acttataaag ttatgagaga ggttaaagcc ttggcttatt     1080

ttgtcaatgg tactgcacat gatgtcattc tatgtgatga cacacctaga ggtttgttag     1140

catgccaata taatactggc aatttttcag atggcttcta tccttttact aatactagta     1200

ttgttaagga taagtttatt gtttatcgtg aaagtagtgt caatactact tgtacattaa     1260

ctaatttcac gtttagtaat gaaagtggtg cccctcctaa tacaggtggt gttgacagtt     1320

ttattttata ccagacacaa acagctcaga gtggttatta taattttaac ttttcatttc     1380

tgagtagttt tgtttatagg gaaagtaatt atatgtatgg atcttaccat ccacgttgta     1440

gttttagacc tgaaaccctt aatggtttgt ggtttaattc cctttctgtt tcattaacat     1500

acggtcccat tcaaggtggt tgtaagcaat ctgtatttaa tggtaaagca acttgttgtt     1560

atgcttattc atacggagga cctcgtggtt gtaaaggtgt ctatagaggt gagctaacac     1620

agcattttga atgtggtttg ttagtttatg ttactaagag cgatggctcc cgtatacaaa     1680

ctgcaacaca accacctgta ttaacccaaa atttttataa taacatcaat ttaggtaagt     1740

gtgttgatta taatatatat ggcagaattg gccaaggtct tattactaat gtaaccgact     1800

tagctgttag ttataattat ttatcagacg caggtttggc tattttagat acatctggtg     1860

ccatagacat cttcgttgta caaggtgaat atggtcctaa ctattataag gttaatccat     1920

gtgaagatgt caaccaacag tttgtagttt ctggtggtaa attagtaggt attctcactt     1980

cacgtaatga aacaggttct cagcttcttg agaaccagtt ttatattaaa atcactaatg     2040

gaactcgtcg ttctagacgt tctgttactg aaaatgttac aaattgccct tatgttagtt     2100

atggcaagtt ttgtataaaa cctgatggtt caatttctgt aatagtacca aaagaactgg     2160

atcagtttgt ggcaccttta cttaatgtta ctgaatatgt gctcatacct aacagtttta     2220

atttaactgt tacagatgag tacatacaaa cgcgtatgga taagatccaa attaattgcc     2280

tgcagtatgt ttgtggcaat tctttggcct gtagaaagct gtttcaacaa tatgggcctg     2340

tttgtgacaa catattgtct gtagtaaata gtgttggtca aaaagaagat atggaacttt     2400

taaatttcta ttcttctact aaaccagctc gttttaatac accagttttt agtaatctta     2460

gcactggtga gtttaatatt tctcttttgt taacatcccc tagtagtcct aggaggcgtt     2520

cttttattga agatctttta tttacaagtg ttgaatctgt aggattacca acagatgacg     2580

catacaaaaa gtgcactgca ggacctttag gcttttttaa agaccttgca tgtgctcgtg     2640

aatataatgg tttgcttgtg ttgcctccta ttataacagc agaaatgcaa actttgtata     2700

ctagttcttt agtagcttct atggcttttg gtggtattac tgcagctggt gccatacctt     2760

ttgccacaca actgcaggct agaattaatc acttgggtat tacccagtca cttttgttga     2820

agaatcaaga aaaaattgct gcttccttta ataaggccat tggtcatatg caggaaggtt     2880

ttaggagtac atctctagca ttacaacaaa ttcaagatgt tgttaataag cagagtgcta     2940

ttcttactga gactatggca gcacttaata aaaattttgg tgctatttct tctgtgattc     3000

aagacattta ccagcaactt gattccatac aagcagatgc tcaagtggat cggctcataa     3060

ctggtagatt gtcatcactt tctgtcttag catctgctaa gcagtcggag tacattagag     3120

tgtcacaaca gcgtgagtta gctactcaga aaattaatga gtgtgttaaa tcacagtcta     3180

ttaggtattc cttttgtggt aatggacgac atgttttaac cataccacaa aatgccccta     3240

atggtatagt gtttatacac tttacttata caccagagag ctttattaat gttactgcaa     3300

tagtgggttt ttgtgtaagt cctgctaatg ctagtcagta tgcaatagtg cccgctaatg     3360

gtaggggtat ttttatacaa gttaatggta gttactacat cactgcacga gatatgtata     3420

tgccaagaga tattactgca ggagatatag ttacgcttac ttcttgtcaa gcaaattatg     3480

taagtgtaaa taagaccgtc attactacat ttgtagacaa tgatgatttt gattttgatg     3540

atgaattgtc aaaatggtgg aatgatacta agcatgagct accagacttt gacaaattca     3600

attacacagt acctatactt gacattgata gtgaaattga tcgtattcaa ggcgttatac     3660

agggtcttaa cgactctcta atagaccttg aaacactatc aatactcaaa acttatatta     3720

agtggccttg gtatgtgtgg ttagccatag cttttgccac tattatcttc atcttaatac     3780

taggatggtt gtttttcatg actggttgtt gtggttgttg ttgtggatgc tttggcatta     3840

ttcctttaat gagtaagtgt ggtaagaaat cttcttatta cacgactttt gataatgatg     3900

tggtaactga acaatacaga cctaaaaagt ctgtttaaat cggatcccgg gcccgtcgac     3960

tgcagaggcc tgcatgcaag cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat     4020

tgttatccgc tcacaattcc acacaacata cgagccggaa gcataaagtg taaagcctgg     4080

ggtgcctaat gagtgagcta actcacatta attgcgttgc gctcactgcc cgctttccag     4140

tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt     4200

ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg     4260

ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg     4320

gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag     4380

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga     4440

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct     4500

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc     4560

tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg     4620

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc     4680

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca     4740

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag     4800

ttcttgaagt ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct     4860

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc     4920

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga     4980

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca     5040

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat     5100

taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac     5160

caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt     5220

gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt     5280

gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag     5340

ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct     5400

attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt     5460

gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc     5520

tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt     5580

agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg     5640

gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg     5700

actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct     5760

tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc     5820

attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt     5880

tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt     5940

tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg     6000

aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta tcagggttat     6060

tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg     6120

cgcacatttc cccgaaaagt gccacctgac gtctaagaaa ccattattat catgacatta     6180

acctataaaa ataggcgtat cacgaggccc tttcgtc                              6217


<210>  79
<211>  11416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  79
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt ggagatcggt acttcgcgaa      420

tgcgtcgaga tcggccgccc gggtaatacg actcactata gggacttaag atagatatta      480

atatatatct attgcactag ccttgcgcta gatttcaaac ttaacaaaac ggacttaaat      540

acctacagct ggtccccata ggtgttccat tgcagtgcac tttagtgccc tggatggcac      600

ctggccacct gtcaggtttt tgttgttaaa atatcattgt tgctggtatc actgcttgtt      660

ttgccgtgtc tcactttata catccgttgc ttgggctacc tagtatccag cgtcctacgg      720

gcgccgtggt cggttcgagt gcgaaggacc tctggttcat ctagcggtag gcgggtgtgt      780

ggaagtagcg cttcagacgt actggttctg ttgcgtgaaa cgcggggtca cctcccccca      840

catacctcta agggcttttg agcctagcgt tgggctacgt tctcgcacaa ggtcggctat      900

acgacgtttg tagggggtag tgccaaacaa cccctgaggt gacaggttct ggtggtgttt      960

cgaaaacaac aatgtgtgtg ccgcataata tgcgcgttat gcattttgga gcaggtagtg     1020

ataaaggagt ggcgcctggt agtactgttc ttaaacagtg gctccccgaa ggaacactcc     1080

ttgtcgataa tgatattgta gattatgttt ctgacgcaca cgtttctgtg ctttcagatt     1140

gcaataaata taagacagag cacaagtttg atcttgtgat atctgatatg tatacagaca     1200

atgattcaaa aagaaagcat gaaggcgtga tagccaataa tggcaatgat gacgtcttca     1260

tatacctttc aagttttcta cgcaataatt tggctctggg aggcagtttt gctgtaaaat     1320

taacagagac aagttggcat gagagtttat atgacattgc acaggattgt gcatggtgga     1380

caatgttttg tacagcagtg aatgcatctt cttcagaagc attcctgatt ggtgttaatt     1440

acttgggtgc aagtgcaaag gttaaagtta gtggaaaaac actgcacgca aattatatat     1500

tttggaggaa ttgtaattat ttacaaacct ctgcttatag tatatttgat gttgctaagt     1560

ttgatttgag attgaaagca acgccagttg ttaatcttaa gactgaacaa aagacagact     1620

tagtctttaa tttgataaag tgtggtaagt tactggtaag agatgttggt aacacctctt     1680

ttactagtga ctcttttgtg tgcactatgt agtgctaatt tatatgacaa cgaatctttt     1740

gtgtattact accagagtgc ttttaggcca ggacatggtt ggcatttaca tggaggtgct     1800

tatgcagtag ttaatgtgtc tagtgaaaat aataatgcag gtactgcccc aagttgcact     1860

gctggtgcta ttggctacag taagaatctc agtgcggcct cagtagccat gactgcacca     1920

ctaagtggta tgtcatggtc tgccaactct ttttgtacag cccactgtaa ttttacttct     1980

tatatagtgt ttgttacaca ttgttataag agcggatcta atagttgtcc tttgacaggt     2040

cttattccaa gcggttatat tcgtattgct gctatgaaac atggaagtgc tatgcctggt     2100

cacttatttt ataatttaac agtttctgtg actaaatatc ctaagtttag atcgctacaa     2160

tgtgttaata attatacttc tgtatattta aatggtgacc ttgttttcac atctaactat     2220

actgaagatg ttgtagctgc aggtgtccat tttaaaagtg gtggacctat aacttataaa     2280

gttatgagag aggttaaagc cttggcttat tttgtcaatg gtactgcaca tgatgtcatt     2340

ctatgtgatg acacacctag aggtttgtta gcatgccaat ataatactgg caatttttca     2400

gatggcttct atccttttac taatactagt attgttaagg ataagtttat tgtttatcgt     2460

gaaagtagtg tcaatactac ttgtacatta actaatttca cgtttagtaa tgaaagtggt     2520

gcccctccta atacaggtgg tgttgacagt tttattttat accagacaca aacagctcag     2580

agtggttatt ataattttaa cttttcattt ctgagtagtt ttgtttatag ggaaagtaat     2640

tatatgtatg gatcttacca tccacgttgt agttttagac ctgaaaccct taatggtttg     2700

tggtttaatt ccctttctgt ttcattaaca tacggtccca ttcaaggtgg ttgtaagcaa     2760

tctgtattta atggtaaagc aacttgttgt tatgcttatt catacggagg acctcgtggt     2820

tgtaaaggtg tctatagagg tgagctaaca cagcattttg aatgtggttt gttagtttat     2880

gttactaaga gcgatggctc ccgtatacaa actgcaacac aaccacctgt attaacccaa     2940

aatttttata ataacatcaa tttaggtaag tgtgttgatt ataatatata tggcagaatt     3000

ggccaaggtc ttattactaa tgtaaccgac ttagctgtta gttataatta tttatcagac     3060

gcaggtttgg ctattttaga tacatctggt gccatagaca tcttcgttgt acaaggtgaa     3120

tatggtccta actattataa ggttaatcca tgtgaagatg tcaaccaaca gtttgtagtt     3180

tctggtggta aattagtagg tattctcact tcacgtaatg aaacaggttc tcagcttctt     3240

gagaaccagt tttatattaa aatcactaat ggaactcgtc gttctagacg ttctgttact     3300

gaaaatgtta caaattgccc ttatgttagt tatggcaagt tttgtataaa acctgatggt     3360

tcaatttctg taatagtacc aaaagaactg gatcagtttg tggcaccttt acttaatgtt     3420

actgaatatg tgctcatacc taacagtttt aatttaactg ttacagatga gtacatacaa     3480

acgcgtatgg ataagatcca aattaattgc ctgcagtatg tttgtggcaa ttctttggcc     3540

tgtagaaagc tgtttcaaca atatgggcct gtttgtgaca acatattgtc tgtagtaaat     3600

agtgttggtc aaaaagaaga tatggaactt ttaaatttct attcttctac taaaccagct     3660

cgttttaata caccagtttt tagtaatctt agcactggtg agtttaatat ttctcttttg     3720

ttaacatccc ctagtagtcc taggaggcgt tcttttattg aagatctttt atttacaagt     3780

gttgaatctg taggattacc aacagatgac gcatacaaaa agtgcactgc aggaccttta     3840

ggctttttta aagaccttgc atgtgctcgt gaatataatg gtttgcttgt gttgcctcct     3900

attataacag cagaaatgca aactttgtat actagttctt tagtagcttc tatggctttt     3960

ggtggtatta ctgcagctgg tgccatacct tttgccacac aactgcaggc tagaattaat     4020

cacttgggta ttacccagtc acttttgttg aagaatcaag aaaaaattgc tgcttccttt     4080

aataaggcca ttggtcatat gcaggaaggt tttaggagta catctctagc attacaacaa     4140

attcaagatg ttgttaataa gcagagtgct attcttactg agactatggc agcacttaat     4200

aaaaattttg gtgctatttc ttctgtgatt caagacattt accagcaact tgattccata     4260

caagcagatg ctcaagtgga tcggctcata actggtagat tgtcatcact ttctgtctta     4320

gcatctgcta agcagtcgga gtacattaga gtgtcacaac agcgtgagtt agctactcag     4380

aaaattaatg agtgtgttaa atcacagtct attaggtatt ccttttgtgg taatggacga     4440

catgttttaa ccataccaca aaatgcccct aatggtatag tgtttataca ctttacttat     4500

acaccagaga gctttattaa tgttactgca atagtgggtt tttgtgtaag tcctgctaat     4560

gctagtcagt atgcaatagt gcccgctaat ggtaggggta tttttataca agttaatggt     4620

agttactaca tcactgcacg agatatgtat atgccaagag atattactgc aggagatata     4680

gttacgctta cttcttgtca agcaaattat gtaagtgtaa ataagaccgt cattactaca     4740

tttgtagaca atgatgattt tgattttgat gatgaattgt caaaatggtg gaatgatact     4800

aagcatgagc taccagactt tgacaaattc aattacacag tacctatact tgacattgat     4860

agtgaaattg atcgtattca aggcgttata cagggtctta acgactctct aatagacctt     4920

gaaacactat caatactcaa aacttatatt aagtggcctt ggtatgtgtg gctagccata     4980

gcttttgcca ctattatctt catcttaata ttaggatggg ttttcttcat gactgggtgt     5040

tgtggttgtt gttgtggatg ctttggcatt atgcctctaa tgagtaagtg tggtaagaaa     5100

tcttcttatt acacgacttt tgataacgat gtggtaactg aacaatacag acctaaaaag     5160

tctgtttaat gatccaaagt cccactagtt tcttaatagt attaattttg ctttggtgta     5220

aacttgtact aagttgtttt agagagttta ttattgccct tcaacaacta acacaagttt     5280

tactccaaat tatcgatagt aatttacagt ctagactgac cctttggcac agtctagact     5340

aatgttaaac ttagaagcaa ttattgaaac cggtgatcaa gtgattcaaa aaatcagttt     5400

caatttacag catatttcaa gtgtattaaa cacagaagta tttgacccct ttgactattg     5460

ttattacaga ggaggtaatt tttgggaaat agagtcagct gaagattgtt caggtgatga     5520

tgaatttatt gaataagtcg ctagaggaga atggaagttt tctaacggca ctttacatat     5580

ttgtaggatt tttagcattt tatcttctag gtagagcact tcaagcattt gtacaggctg     5640

ctgatgcttg ttgtttattt tggtacacgt ggttagtaat tccaggagtt aagggtacag     5700

cctttgtata caagtataca tatggtagaa aacttaacaa ttcggaatta gaagcagttg     5760

ttgttaacga gtttcctaag aacggttgga ataataaaaa tccagcaaat tttcaagatg     5820

tccaacgaaa caaattgtac tcttgacttt gaacagtcag ttgagctttt taaagagtat     5880

aatttattta taactgcatt cttgttgttc ttaaccataa tacttcagta tggttatgca     5940

acgcgtagta agtttattta tatacttaaa atgatagtgt tatggtgctt ttggcccctt     6000

aacattgcag taggtgtaat ttcatgtata tacccaccaa acacaggagg tcttgtcgca     6060

gcgataatac ttactgtgtt tgcgtgtctt tcttttgtag gttattggat ccagagtatt     6120

agactcttta agcggtgtag atcttggtgg tcatttaacc cagaatctaa cgccgtaggt     6180

tcaatactcc taactaatgg tcaacaatgt aattttgcta tagagagtgt gccgatggtg     6240

ctttctccta ttataaagaa tggtgttctt tattgtgagg gtcagtggct tgctaaatgt     6300

gaaccagacc acttgcctaa agacatattt gtatgcacac cagatagacg taatatctat     6360

cgtatggtgc agaaatacac tggtgaccaa agcggaaata agaaaaggtt tgctacattt     6420

gtctatgcaa agcagtcagt agacactggc gagctagaaa gtgtagcaac aggtggaagt     6480

agcctttaca cataaatgtg tgtgtgtaga gagtatttaa aattattctt caatagtgcc     6540

tctattttaa gagcgcggaa gagtatttgt tttgaggata ttaatataaa tcctctttgt     6600

tttgtactct ctttacaaga gttattattt aagcaacagt ttttcctttc ctttgtttgg     6660

aagaaagttg ttgttaatgg tgtagaattc caagtagaaa atggaaaagt ccactacgaa     6720

ggaaacccca ttttccaaaa aggttgttgt aggttgtggt cccattataa gaaggattaa     6780

atggattaaa ccacctacac tacttacttg taataagggc gtttggactt acaagcgctt     6840

aacaaataca gacgatgaaa tggctgacta gttttggaag agcagttatt tcttgttata     6900

aagccctact attaactcag ttaagagtat tagataggtt aattttagat cacggaccaa     6960

agcgagtctt aacgtgtggt aggcgagtgc ttttatctca attagattta gtttataggt     7020

tggcatatac gcccacccaa tcgctggtat gaataatagt aaagataatc cttttcgcgg     7080

agcaatagca agaaaagcgc gaatttatct gagagaagga ttagagtgtg tttactttct     7140

taacaaagca ggacaagcag agccttgtcc cgcgtgtacc tccctagtat ttcaggggaa     7200

aacttgtgag gaacacacag ataataataa tcttttgtca tggcgagcgg taagacaact     7260

gggaagacag acgccccagc gccagtcatc aaactaggag ggccaaaacc acctaaagtt     7320

ggttcttctg gaaatgctag ctggtttcaa gcactaaaag ccaagaagtt aaattcacct     7380

cctcctaagt ttgaaggtag cggcgttcct gataatgaaa atcttaaatt aagccagcaa     7440

catgggtact ggagacgtca agccaggtac aagccaggta aaggcggaag aaaatcagtc     7500

ccagatgctt ggtacttcta ttacactgga acaggaccag ccgctgacct gaattggggt     7560

gatagccaag atggtatagt gtgggtttct gcaaagggtg ctgatactaa atctagatct     7620

aaccagggta caagggatcc tgataagttt gaccaatacc cgctacgatt ctcagatgga     7680

ggacctgatg gtaatttccg ttgggacttc attccaataa atcgtggtag gagtggaaga     7740

tcaacagcgg cttcatcagc agcatctagt agagcaccgt cgcgtgatgg ctcgcgtgga     7800

cgtagaagcg gagctgaaga tgatcttata gctcgtgcag caaagatcat tcaggatcag     7860

cagaagaagg gttctcgcat tactaaagct aaggccgatg aaatggctca tcgccggtat     7920

tgtaagcgta ctatcccacc tggttataag gttgatcaag tatttggtcc ccgtactaaa     7980

ggtaaggagg gaaattttgg tgatgacaag atgaatgagg agggtattaa ggatgggcgc     8040

gttacagcaa tgctcaacct agtccctagc agccatgctt gtctttttgg aagtagagtg     8100

acgcccaaac ttcaaccaga tgggctgcac ttgagatttg aatttactac tgtggtttct     8160

agggatgatc cgcagtttga taattatgtg aaaatttgtg atcagtgtgt cgatggtgta     8220

gggactcggc caaaagacga tgaaccgaga ccaaagtcac gcccaaattc aagacctgct     8280

acaagaacaa gttctccagc gccaagacaa cagcgtcaaa agaaggagaa gaagtcaaag     8340

aagcaggatg atgaagtaga taaggcattg acctcagatg aggagaggaa caatgcacag     8400

ctggaatttg atgatgaacc gaaagtgatt aactgggggg attcagcact tggagagaat     8460

gagttgtaaa gctagatttc caacttaaca tcatggacgt gcgtatgctg tttttcccta     8520

ctatagactt tttagcatat tattttttgc tatttgtatg gtttattaca ggtgaagatt     8580

gtatgtattt gttgtacact cgtatgttct atattatgtt ttctgtagtt gttattagtg     8640

ttgttcttgt tcttactcta ctgttctctt ttctttattt tagagtatca ataagaatca     8700

aggaagatag gcatgtagtt tgattaccta catgtctatc gccagggaaa tgtctaatct     8760

gtctacttag tagcctggaa acgaacggta gacccttaga ttttaattta gtttaatttt     8820

tagtttagtt taagttagtt tagagtaggt ataaagaagc cagtgccggg gccacgcgga     8880

gtacgatcga gggtacagca ctaggacgcc cactagggga agagctaaat tttagtttaa     8940

gttaagttta attggctaag tatagttaaa atttataggc tagtatagag ttagagcaaa     9000

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     9060

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaagtt taaacttaat taagaattcc     9120

cttggctcga gttcgaaatc ggatgccggg accgacgagt gcagaggcgt gcaagcgagc     9180

ttggcgtaat catggtcata gctgtttcct gtgtgaaatt gttatccgct cacaattcca     9240

cacaacatac gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa     9300

ctcacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag     9360

ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc     9420

gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct     9480

cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg     9540

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     9600

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     9660

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     9720

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     9780

gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     9840

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     9900

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     9960

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac    10020

tacggctaca ctagaagaac agtatttggt atctgcgctc tgctgaagcc agttaccttc    10080

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt    10140

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc    10200

ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg    10260

agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca    10320

atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca    10380

cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag    10440

ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac    10500

ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc    10560

agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct    10620

agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc    10680

gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg    10740

cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc    10800

gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat    10860

tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag    10920

tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat    10980

aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg    11040

cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca    11100

cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga    11160

aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc    11220

ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag cggatacata    11280

tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg    11340

ccacctgacg tctaagaaac cattattatc atgacattaa cctataaaaa taggcgtatc    11400

acgaggccct ttcgtc                                                    11416


<210>  80
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  80
catataaatt agcactacat agtgcacac                                         29


<210>  81
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  81
atgtagtgct aatttatatg acaacgaatc ttttg                                  35


<210>  82
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  82
acacatacca aggccactta atataagttt tg                                     32


<210>  83
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  83
taagtggcct tggtatgtgt ggctagcc                                          28


<210>  84
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  84
taatactggy aatttttcag a                                                 21


