                         SEQUENCE LISTING

<110>  The Wistar Institute of Anatomy and Biology
       Weiner, David B
       Louis, Lumena
 
<120>  DNA ENCODED IL-36 GAMMA AS AN ADJUVANT

<130>  206193-0014-00WO

<150>  US 62/845,011
<151>  2019-05-08

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 alpha full length

<400>  1
gaaaaagccc tgaagattga cacccctcag cagggctcta tccaggacat caaccaccgg       60

gtgtgggtgc tgcaggatca gaccctgatc gccgtgccac ggaaggacag aatgagcccc      120

gtgaccatcg ccctgatctc ctgcaggcac gtggagacac tggagaagga tcgcggcaat      180

cccatctacc tgggcctgaa cggcctgaat ctgtgcctga tgtgcgcaaa agtgggcgac      240

cagcctaccc tgcagctgaa ggagaaggac atcatggatc tgtacaacca gcccgagcct      300

gtgaagtcct tcctgtttta tcactctcag agcggcagga attccacatt cgagtctgtg      360

gccttccctg gctggtttat cgccgtgagc tccgagggcg gctgtccact gattctgact      420

caggaactgg ggaaggctaa tactaccgat tttggactga ctatgctgtt t               471


<210>  2
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 alpha full length

<400>  2

Glu Lys Ala Leu Lys Ile Asp Thr Pro Gln Gln Gly Ser Ile Gln Asp 
1               5                   10                  15      


Ile Asn His Arg Val Trp Val Leu Gln Asp Gln Thr Leu Ile Ala Val 
            20                  25                  30          


Pro Arg Lys Asp Arg Met Ser Pro Val Thr Ile Ala Leu Ile Ser Cys 
        35                  40                  45              


Arg His Val Glu Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile Tyr Leu 
    50                  55                  60                  


Gly Leu Asn Gly Leu Asn Leu Cys Leu Met Cys Ala Lys Val Gly Asp 
65                  70                  75                  80  


Gln Pro Thr Leu Gln Leu Lys Glu Lys Asp Ile Met Asp Leu Tyr Asn 
                85                  90                  95      


Gln Pro Glu Pro Val Lys Ser Phe Leu Phe Tyr His Ser Gln Ser Gly 
            100                 105                 110         


Arg Asn Ser Thr Phe Glu Ser Val Ala Phe Pro Gly Trp Phe Ile Ala 
        115                 120                 125             


Val Ser Ser Glu Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu Leu Gly 
    130                 135                 140                 


Lys Ala Asn Thr Thr Asp Phe Gly Leu Thr Met Leu Phe 
145                 150                 155         


<210>  3
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 alpha truncated

<400>  3
aagattgata cacctcagca gggaagcatt caggacatca accaccgggt gtgggtgctg       60

caggatcaga ccctgatcgc cgtgccacgg aaggacagaa tgagccccgt gaccatcgcc      120

ctgatctcct gcaggcacgt ggagacactg gagaaggatc gcggcaatcc catctacctg      180

ggcctgaacg gcctgaatct gtgcctgatg tgcgcaaaag tgggcgacca gcctaccctg      240

cagctgaagg agaaggacat catggatctg tacaaccagc ccgagcctgt gaagtctttc      300

ctgttttatc actctcagag cggcaggaat tccacattcg agtctgtggc cttccctggc      360

tggtttatcg ccgtgagctc cgagggcggc tgtccactga ttctgaccca ggaactgggc      420

aaggctaata ccactgactt cggactgact atgctgttt                             459


<210>  4
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 alpha truncated

<400>  4

Lys Ile Asp Thr Pro Gln Gln Gly Ser Ile Gln Asp Ile Asn His Arg 
1               5                   10                  15      


Val Trp Val Leu Gln Asp Gln Thr Leu Ile Ala Val Pro Arg Lys Asp 
            20                  25                  30          


Arg Met Ser Pro Val Thr Ile Ala Leu Ile Ser Cys Arg His Val Glu 
        35                  40                  45              


Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile Tyr Leu Gly Leu Asn Gly 
    50                  55                  60                  


Leu Asn Leu Cys Leu Met Cys Ala Lys Val Gly Asp Gln Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Glu Lys Asp Ile Met Asp Leu Tyr Asn Gln Pro Glu Pro 
                85                  90                  95      


Val Lys Ser Phe Leu Phe Tyr His Ser Gln Ser Gly Arg Asn Ser Thr 
            100                 105                 110         


Phe Glu Ser Val Ala Phe Pro Gly Trp Phe Ile Ala Val Ser Ser Glu 
        115                 120                 125             


Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu Leu Gly Lys Ala Asn Thr 
    130                 135                 140                 


Thr Asp Phe Gly Leu Thr Met Leu Phe 
145                 150             


<210>  5
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 beta full length

<400>  5
aacccacagc gagaggcagc ccccaaaagc tacgccatcc gggactctag acagatggtg       60

tgggtgctgt ccggcaactc tctgatcgca gcccctctga gccggagcat caagcctgtg      120

accctgcacc tgatcgcctg tcgcgacaca gagttctccg ataaggagaa gggcaatatg      180

gtgtacctgg gcatcaaggg caaggatctg tgcctgtttt gtgccgagat ccagggcaag      240

cccaccctgc agctgaagct gcagggcagc caggacaaca tcggcaagga tacctgctgg      300

aagctggtgg gcatccacac atgtatcaat ctggacgtgc gggagtcctg cttcatgggc      360

acactggatc agtggggcat cggcgtgggc aggaagaagt ggaagagctc ctttcagcac      420

caccacctgc gcaaaaaaga caaggacttc agctctatga gaactaacat tgggatgcct      480

gggaggatg                                                              489


<210>  6
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 beta full length

<400>  6

Asn Pro Gln Arg Glu Ala Ala Pro Lys Ser Tyr Ala Ile Arg Asp Ser 
1               5                   10                  15      


Arg Gln Met Val Trp Val Leu Ser Gly Asn Ser Leu Ile Ala Ala Pro 
            20                  25                  30          


Leu Ser Arg Ser Ile Lys Pro Val Thr Leu His Leu Ile Ala Cys Arg 
        35                  40                  45              


Asp Thr Glu Phe Ser Asp Lys Glu Lys Gly Asn Met Val Tyr Leu Gly 
    50                  55                  60                  


Ile Lys Gly Lys Asp Leu Cys Leu Phe Cys Ala Glu Ile Gln Gly Lys 
65                  70                  75                  80  


Pro Thr Leu Gln Leu Lys Leu Gln Gly Ser Gln Asp Asn Ile Gly Lys 
                85                  90                  95      


Asp Thr Cys Trp Lys Leu Val Gly Ile His Thr Cys Ile Asn Leu Asp 
            100                 105                 110         


Val Arg Glu Ser Cys Phe Met Gly Thr Leu Asp Gln Trp Gly Ile Gly 
        115                 120                 125             


Val Gly Arg Lys Lys Trp Lys Ser Ser Phe Gln His His His Leu Arg 
    130                 135                 140                 


Lys Lys Asp Lys Asp Phe Ser Ser Met Arg Thr Asn Ile Gly Met Pro 
145                 150                 155                 160 


Gly Arg Met 
            


<210>  7
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 beta truncated

<400>  7
agggaagccg cccccaaaag ctacgctatc agggactctc ggcagatggt gtgggtgctg       60

tccggcaact ctctgatcgc agcccctctg agccggagca tcaagcctgt gaccctgcac      120

ctgatcgcct gtagagacac agagttctcc gataaggaga agggcaatat ggtgtacctg      180

ggcatcaagg gcaaggatct gtgcctgttt tgtgccgaga tccagggcaa gcccaccctg      240

cagctgaagc tgcagggcag ccaggacaac atcggcaagg atacctgctg gaagctggtg      300

ggcatccaca catgtatcaa tctggacgtg agggagtcct gcttcatggg cacactggat      360

cagtggggaa tcggagtggg acgcaagaag tggaagagct cctttcagca ccaccacctg      420

aggaagaagg ataaagattt cagcagtatg cggactaaca ttgggatgcc agggaggatg      480


<210>  8
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 beta truncated

<400>  8

Arg Glu Ala Ala Pro Lys Ser Tyr Ala Ile Arg Asp Ser Arg Gln Met 
1               5                   10                  15      


Val Trp Val Leu Ser Gly Asn Ser Leu Ile Ala Ala Pro Leu Ser Arg 
            20                  25                  30          


Ser Ile Lys Pro Val Thr Leu His Leu Ile Ala Cys Arg Asp Thr Glu 
        35                  40                  45              


Phe Ser Asp Lys Glu Lys Gly Asn Met Val Tyr Leu Gly Ile Lys Gly 
    50                  55                  60                  


Lys Asp Leu Cys Leu Phe Cys Ala Glu Ile Gln Gly Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Leu Gln Gly Ser Gln Asp Asn Ile Gly Lys Asp Thr Cys 
                85                  90                  95      


Trp Lys Leu Val Gly Ile His Thr Cys Ile Asn Leu Asp Val Arg Glu 
            100                 105                 110         


Ser Cys Phe Met Gly Thr Leu Asp Gln Trp Gly Ile Gly Val Gly Arg 
        115                 120                 125             


Lys Lys Trp Lys Ser Ser Phe Gln His His His Leu Arg Lys Lys Asp 
    130                 135                 140                 


Lys Asp Phe Ser Ser Met Arg Thr Asn Ile Gly Met Pro Gly Arg Met 
145                 150                 155                 160 


<210>  9
<211>  504
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 gamma full length

<400>  9
agaggaaccc ccggagatgc tgatggagga ggacgggccg tgtaccagag catgtgcaag       60

cctatcaccg gcacaatcaa cgacctgaat cagcaagtgt ggaccctgca gggacagaac      120

ctggtggcag tgccaaggtc tgatagcgtg acccccgtga cagtggccgt gatcacctgt      180

aagtatccag aggccctgga gcagggacgc ggcgacccta tctacctggg catccagaat      240

ccagagatgt gcctgtattg tgagaaagtg ggcgagcagc caaccctgca gctgaaggag      300

cagaagatca tggatctgta cggccagccc gagcctgtga agcccttcct gttttatcgg      360

gccaagacag gcagaacctc cacactggag tctgtggcct tccccgactg gtttatcgcc      420

agctccaaga gggatcagcc tatcatcctg acctctgaac tggggaaatc ctacaatact      480

gcttttgaac tgaacattaa cgac                                             504


<210>  10
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 gamma full length

<400>  10

Arg Gly Thr Pro Gly Asp Ala Asp Gly Gly Gly Arg Ala Val Tyr Gln 
1               5                   10                  15      


Ser Met Cys Lys Pro Ile Thr Gly Thr Ile Asn Asp Leu Asn Gln Gln 
            20                  25                  30          


Val Trp Thr Leu Gln Gly Gln Asn Leu Val Ala Val Pro Arg Ser Asp 
        35                  40                  45              


Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys Lys Tyr Pro Glu 
    50                  55                  60                  


Ala Leu Glu Gln Gly Arg Gly Asp Pro Ile Tyr Leu Gly Ile Gln Asn 
65                  70                  75                  80  


Pro Glu Met Cys Leu Tyr Cys Glu Lys Val Gly Glu Gln Pro Thr Leu 
                85                  90                  95      


Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly Gln Pro Glu Pro 
            100                 105                 110         


Val Lys Pro Phe Leu Phe Tyr Arg Ala Lys Thr Gly Arg Thr Ser Thr 
        115                 120                 125             


Leu Glu Ser Val Ala Phe Pro Asp Trp Phe Ile Ala Ser Ser Lys Arg 
    130                 135                 140                 


Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys Ser Tyr Asn Thr 
145                 150                 155                 160 


Ala Phe Glu Leu Asn Ile Asn Asp 
                165             


<210>  11
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 gamma truncated

<400>  11
agcatgtgca agcctattac tgggactatc aatgacctga accagcaagt gtggaccctg       60

cagggccaga atctggtggc cgtgccaagg tctgatagcg tgacccccgt gacagtggcc      120

gtgatcacat gcaagtaccc tgaggccctg gagcagggac gcggcgaccc tatctacctg      180

ggcatccaga acccagagat gtgcctgtat tgtgagaaag tgggcgagca gccaaccctg      240

cagctgaagg agcagaagat catggatctg tacggccagc ccgagcctgt gaagcccttc      300

ctgttttatc gggccaagac aggcagaacc tccacactgg agtctgtggc cttccccgac      360

tggtttatcg ccagctccaa gcgggatcag cctatcattc tgacctccga actggggaag      420

tcctacaata cagcctttga actgaacatt aacgac                                456


<210>  12
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 gamma truncated

<400>  12

Ser Met Cys Lys Pro Ile Thr Gly Thr Ile Asn Asp Leu Asn Gln Gln 
1               5                   10                  15      


Val Trp Thr Leu Gln Gly Gln Asn Leu Val Ala Val Pro Arg Ser Asp 
            20                  25                  30          


Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys Lys Tyr Pro Glu 
        35                  40                  45              


Ala Leu Glu Gln Gly Arg Gly Asp Pro Ile Tyr Leu Gly Ile Gln Asn 
    50                  55                  60                  


Pro Glu Met Cys Leu Tyr Cys Glu Lys Val Gly Glu Gln Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly Gln Pro Glu Pro 
                85                  90                  95      


Val Lys Pro Phe Leu Phe Tyr Arg Ala Lys Thr Gly Arg Thr Ser Thr 
            100                 105                 110         


Leu Glu Ser Val Ala Phe Pro Asp Trp Phe Ile Ala Ser Ser Lys Arg 
        115                 120                 125             


Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys Ser Tyr Asn Thr 
    130                 135                 140                 


Ala Phe Glu Leu Asn Ile Asn Asp 
145                 150         


<210>  13
<211>  531
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 alpha full length

<400>  13
atggactgga cttggattct gttcctggtc gccgccgcaa ctagagtgca ttccgaaaaa       60

gccctgaaga ttgacacccc tcagcagggc tctatccagg acatcaacca ccgggtgtgg      120

gtgctgcagg atcagaccct gatcgccgtg ccacggaagg acagaatgag ccccgtgacc      180

atcgccctga tctcctgcag gcacgtggag acactggaga aggatcgcgg caatcccatc      240

tacctgggcc tgaacggcct gaatctgtgc ctgatgtgcg caaaagtggg cgaccagcct      300

accctgcagc tgaaggagaa ggacatcatg gatctgtaca accagcccga gcctgtgaag      360

tccttcctgt tttatcactc tcagagcggc aggaattcca cattcgagtc tgtggccttc      420

cctggctggt ttatcgccgt gagctccgag ggcggctgtc cactgattct gactcaggaa      480

ctggggaagg ctaatactac cgattttgga ctgactatgc tgttttgata a               531


<210>  14
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 alpha full length

<400>  14

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Glu Lys Ala Leu Lys Ile Asp Thr Pro Gln Gln Gly Ser Ile 
            20                  25                  30          


Gln Asp Ile Asn His Arg Val Trp Val Leu Gln Asp Gln Thr Leu Ile 
        35                  40                  45              


Ala Val Pro Arg Lys Asp Arg Met Ser Pro Val Thr Ile Ala Leu Ile 
    50                  55                  60                  


Ser Cys Arg His Val Glu Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile 
65                  70                  75                  80  


Tyr Leu Gly Leu Asn Gly Leu Asn Leu Cys Leu Met Cys Ala Lys Val 
                85                  90                  95      


Gly Asp Gln Pro Thr Leu Gln Leu Lys Glu Lys Asp Ile Met Asp Leu 
            100                 105                 110         


Tyr Asn Gln Pro Glu Pro Val Lys Ser Phe Leu Phe Tyr His Ser Gln 
        115                 120                 125             


Ser Gly Arg Asn Ser Thr Phe Glu Ser Val Ala Phe Pro Gly Trp Phe 
    130                 135                 140                 


Ile Ala Val Ser Ser Glu Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu 
145                 150                 155                 160 


Leu Gly Lys Ala Asn Thr Thr Asp Phe Gly Leu Thr Met Leu Phe 
                165                 170                 175 


<210>  15
<211>  519
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 alpha truncated

<400>  15
atggactgga catggattct gtttctggtc gccgccgcaa ctcgcgtgca tagcaagatt       60

gatacacctc agcagggaag cattcaggac atcaaccacc gggtgtgggt gctgcaggat      120

cagaccctga tcgccgtgcc acggaaggac agaatgagcc ccgtgaccat cgccctgatc      180

tcctgcaggc acgtggagac actggagaag gatcgcggca atcccatcta cctgggcctg      240

aacggcctga atctgtgcct gatgtgcgca aaagtgggcg accagcctac cctgcagctg      300

aaggagaagg acatcatgga tctgtacaac cagcccgagc ctgtgaagtc tttcctgttt      360

tatcactctc agagcggcag gaattccaca ttcgagtctg tggccttccc tggctggttt      420

atcgccgtga gctccgaggg cggctgtcca ctgattctga cccaggaact gggcaaggct      480

aataccactg acttcggact gactatgctg ttttgataa                             519


<210>  16
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 alpha truncated

<400>  16

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Lys Ile Asp Thr Pro Gln Gln Gly Ser Ile Gln Asp Ile Asn 
            20                  25                  30          


His Arg Val Trp Val Leu Gln Asp Gln Thr Leu Ile Ala Val Pro Arg 
        35                  40                  45              


Lys Asp Arg Met Ser Pro Val Thr Ile Ala Leu Ile Ser Cys Arg His 
    50                  55                  60                  


Val Glu Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile Tyr Leu Gly Leu 
65                  70                  75                  80  


Asn Gly Leu Asn Leu Cys Leu Met Cys Ala Lys Val Gly Asp Gln Pro 
                85                  90                  95      


Thr Leu Gln Leu Lys Glu Lys Asp Ile Met Asp Leu Tyr Asn Gln Pro 
            100                 105                 110         


Glu Pro Val Lys Ser Phe Leu Phe Tyr His Ser Gln Ser Gly Arg Asn 
        115                 120                 125             


Ser Thr Phe Glu Ser Val Ala Phe Pro Gly Trp Phe Ile Ala Val Ser 
    130                 135                 140                 


Ser Glu Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu Leu Gly Lys Ala 
145                 150                 155                 160 


Asn Thr Thr Asp Phe Gly Leu Thr Met Leu Phe 
                165                 170     


<210>  17
<211>  549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 beta full length

<400>  17
atggactgga catggattct gttcctggtc gcagccgcca caagagtgca ttcaaaccca       60

cagcgagagg cagcccccaa aagctacgcc atccgggact ctagacagat ggtgtgggtg      120

ctgtccggca actctctgat cgcagcccct ctgagccgga gcatcaagcc tgtgaccctg      180

cacctgatcg cctgtcgcga cacagagttc tccgataagg agaagggcaa tatggtgtac      240

ctgggcatca agggcaagga tctgtgcctg ttttgtgccg agatccaggg caagcccacc      300

ctgcagctga agctgcaggg cagccaggac aacatcggca aggatacctg ctggaagctg      360

gtgggcatcc acacatgtat caatctggac gtgcgggagt cctgcttcat gggcacactg      420

gatcagtggg gcatcggcgt gggcaggaag aagtggaaga gctcctttca gcaccaccac      480

ctgcgcaaaa aagacaagga cttcagctct atgagaacta acattgggat gcctgggagg      540

atgtgataa                                                              549


<210>  18
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 beta full length

<400>  18

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Pro Gln Arg Glu Ala Ala Pro Lys Ser Tyr Ala Ile Arg 
            20                  25                  30          


Asp Ser Arg Gln Met Val Trp Val Leu Ser Gly Asn Ser Leu Ile Ala 
        35                  40                  45              


Ala Pro Leu Ser Arg Ser Ile Lys Pro Val Thr Leu His Leu Ile Ala 
    50                  55                  60                  


Cys Arg Asp Thr Glu Phe Ser Asp Lys Glu Lys Gly Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gly Ile Lys Gly Lys Asp Leu Cys Leu Phe Cys Ala Glu Ile Gln 
                85                  90                  95      


Gly Lys Pro Thr Leu Gln Leu Lys Leu Gln Gly Ser Gln Asp Asn Ile 
            100                 105                 110         


Gly Lys Asp Thr Cys Trp Lys Leu Val Gly Ile His Thr Cys Ile Asn 
        115                 120                 125             


Leu Asp Val Arg Glu Ser Cys Phe Met Gly Thr Leu Asp Gln Trp Gly 
    130                 135                 140                 


Ile Gly Val Gly Arg Lys Lys Trp Lys Ser Ser Phe Gln His His His 
145                 150                 155                 160 


Leu Arg Lys Lys Asp Lys Asp Phe Ser Ser Met Arg Thr Asn Ile Gly 
                165                 170                 175     


Met Pro Gly Arg Met 
            180     


<210>  19
<211>  540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 beta truncated

<400>  19
atggactgga catggattct gtttctggtc gcagcagcca caagagtgca ttcaagggaa       60

gccgccccca aaagctacgc tatcagggac tctcggcaga tggtgtgggt gctgtccggc      120

aactctctga tcgcagcccc tctgagccgg agcatcaagc ctgtgaccct gcacctgatc      180

gcctgtagag acacagagtt ctccgataag gagaagggca atatggtgta cctgggcatc      240

aagggcaagg atctgtgcct gttttgtgcc gagatccagg gcaagcccac cctgcagctg      300

aagctgcagg gcagccagga caacatcggc aaggatacct gctggaagct ggtgggcatc      360

cacacatgta tcaatctgga cgtgagggag tcctgcttca tgggcacact ggatcagtgg      420

ggaatcggag tgggacgcaa gaagtggaag agctcctttc agcaccacca cctgaggaag      480

aaggataaag atttcagcag tatgcggact aacattggga tgccagggag gatgtgataa      540


<210>  20
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 beta truncated

<400>  20

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Arg Glu Ala Ala Pro Lys Ser Tyr Ala Ile Arg Asp Ser Arg 
            20                  25                  30          


Gln Met Val Trp Val Leu Ser Gly Asn Ser Leu Ile Ala Ala Pro Leu 
        35                  40                  45              


Ser Arg Ser Ile Lys Pro Val Thr Leu His Leu Ile Ala Cys Arg Asp 
    50                  55                  60                  


Thr Glu Phe Ser Asp Lys Glu Lys Gly Asn Met Val Tyr Leu Gly Ile 
65                  70                  75                  80  


Lys Gly Lys Asp Leu Cys Leu Phe Cys Ala Glu Ile Gln Gly Lys Pro 
                85                  90                  95      


Thr Leu Gln Leu Lys Leu Gln Gly Ser Gln Asp Asn Ile Gly Lys Asp 
            100                 105                 110         


Thr Cys Trp Lys Leu Val Gly Ile His Thr Cys Ile Asn Leu Asp Val 
        115                 120                 125             


Arg Glu Ser Cys Phe Met Gly Thr Leu Asp Gln Trp Gly Ile Gly Val 
    130                 135                 140                 


Gly Arg Lys Lys Trp Lys Ser Ser Phe Gln His His His Leu Arg Lys 
145                 150                 155                 160 


Lys Asp Lys Asp Phe Ser Ser Met Arg Thr Asn Ile Gly Met Pro Gly 
                165                 170                 175     


Arg Met 
        


<210>  21
<211>  564
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 gamma full length

<400>  21
atggattgga cctggattct gtttctggtc gccgctgcta caagagtgca ttcaagagga       60

acccccggag atgctgatgg aggaggacgg gccgtgtacc agagcatgtg caagcctatc      120

accggcacaa tcaacgacct gaatcagcaa gtgtggaccc tgcagggaca gaacctggtg      180

gcagtgccaa ggtctgatag cgtgaccccc gtgacagtgg ccgtgatcac ctgtaagtat      240

ccagaggccc tggagcaggg acgcggcgac cctatctacc tgggcatcca gaatccagag      300

atgtgcctgt attgtgagaa agtgggcgag cagccaaccc tgcagctgaa ggagcagaag      360

atcatggatc tgtacggcca gcccgagcct gtgaagccct tcctgtttta tcgggccaag      420

acaggcagaa cctccacact ggagtctgtg gccttccccg actggtttat cgccagctcc      480

aagagggatc agcctatcat cctgacctct gaactgggga aatcctacaa tactgctttt      540

gaactgaaca ttaacgactg ataa                                             564


<210>  22
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 gamma full length

<400>  22

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Arg Gly Thr Pro Gly Asp Ala Asp Gly Gly Gly Arg Ala Val 
            20                  25                  30          


Tyr Gln Ser Met Cys Lys Pro Ile Thr Gly Thr Ile Asn Asp Leu Asn 
        35                  40                  45              


Gln Gln Val Trp Thr Leu Gln Gly Gln Asn Leu Val Ala Val Pro Arg 
    50                  55                  60                  


Ser Asp Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys Lys Tyr 
65                  70                  75                  80  


Pro Glu Ala Leu Glu Gln Gly Arg Gly Asp Pro Ile Tyr Leu Gly Ile 
                85                  90                  95      


Gln Asn Pro Glu Met Cys Leu Tyr Cys Glu Lys Val Gly Glu Gln Pro 
            100                 105                 110         


Thr Leu Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly Gln Pro 
        115                 120                 125             


Glu Pro Val Lys Pro Phe Leu Phe Tyr Arg Ala Lys Thr Gly Arg Thr 
    130                 135                 140                 


Ser Thr Leu Glu Ser Val Ala Phe Pro Asp Trp Phe Ile Ala Ser Ser 
145                 150                 155                 160 


Lys Arg Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys Ser Tyr 
                165                 170                 175     


Asn Thr Ala Phe Glu Leu Asn Ile Asn Asp 
            180                 185     


<210>  23
<211>  516
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 gamma truncated

<400>  23
atggactgga cctggattct gttcctggtc gctgccgcta caagagtgca ttcaagcatg       60

tgcaagccta ttactgggac tatcaatgac ctgaaccagc aagtgtggac cctgcagggc      120

cagaatctgg tggccgtgcc aaggtctgat agcgtgaccc ccgtgacagt ggccgtgatc      180

acatgcaagt accctgaggc cctggagcag ggacgcggcg accctatcta cctgggcatc      240

cagaacccag agatgtgcct gtattgtgag aaagtgggcg agcagccaac cctgcagctg      300

aaggagcaga agatcatgga tctgtacggc cagcccgagc ctgtgaagcc cttcctgttt      360

tatcgggcca agacaggcag aacctccaca ctggagtctg tggccttccc cgactggttt      420

atcgccagct ccaagcggga tcagcctatc attctgacct ccgaactggg gaagtcctac      480

aatacagcct ttgaactgaa cattaacgac tgataa                                516


<210>  24
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human IL-36 gamma truncated

<400>  24

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Met Cys Lys Pro Ile Thr Gly Thr Ile Asn Asp Leu Asn 
            20                  25                  30          


Gln Gln Val Trp Thr Leu Gln Gly Gln Asn Leu Val Ala Val Pro Arg 
        35                  40                  45              


Ser Asp Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys Lys Tyr 
    50                  55                  60                  


Pro Glu Ala Leu Glu Gln Gly Arg Gly Asp Pro Ile Tyr Leu Gly Ile 
65                  70                  75                  80  


Gln Asn Pro Glu Met Cys Leu Tyr Cys Glu Lys Val Gly Glu Gln Pro 
                85                  90                  95      


Thr Leu Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly Gln Pro 
            100                 105                 110         


Glu Pro Val Lys Pro Phe Leu Phe Tyr Arg Ala Lys Thr Gly Arg Thr 
        115                 120                 125             


Ser Thr Leu Glu Ser Val Ala Phe Pro Asp Trp Phe Ile Ala Ser Ser 
    130                 135                 140                 


Lys Arg Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys Ser Tyr 
145                 150                 155                 160 


Asn Thr Ala Phe Glu Leu Asn Ile Asn Asp 
                165                 170 


<210>  25
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Full length IL-36 alpha

<400>  25
atggactgga cctggattct gttcctcgtc gccgccgcaa ctagggtgca ttcaaacaaa       60

gaaaaagaac tccgggctgc ctccccctcc ctgaggcacg tgcaggacct cagctccaga      120

gtctggattc tgcagaacaa tattctcacc gctgtgccca ggaaggagca gacagtgcct      180

gtcactatca ccctgctccc atgccagtac ctggacacac tcgaaactaa ccggggcgac      240

cccacatata tgggtgtgca gcgccctatg tcttgcctgt tctgtactaa ggatggagag      300

cagcctgtcc tgcagctcgg agagggaaac atcatggaaa tgtacaataa gaaggaacca      360

gtgaaagcaa gtctgttcta tcacaagaaa tcagggacca caagcacctt tgagtccgcc      420

gctttcccag gctggtttat cgccgtgtgc tctaaaggaa gttgtcccct gattctcact      480

caggagctgg gtgaaatctt cattaccgac tttgaaatga tcgtggtcca ttgataa         537


<210>  26
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Full length IL-36 alpha

<400>  26

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Lys Glu Lys Glu Leu Arg Ala Ala Ser Pro Ser Leu Arg 
            20                  25                  30          


His Val Gln Asp Leu Ser Ser Arg Val Trp Ile Leu Gln Asn Asn Ile 
        35                  40                  45              


Leu Thr Ala Val Pro Arg Lys Glu Gln Thr Val Pro Val Thr Ile Thr 
    50                  55                  60                  


Leu Leu Pro Cys Gln Tyr Leu Asp Thr Leu Glu Thr Asn Arg Gly Asp 
65                  70                  75                  80  


Pro Thr Tyr Met Gly Val Gln Arg Pro Met Ser Cys Leu Phe Cys Thr 
                85                  90                  95      


Lys Asp Gly Glu Gln Pro Val Leu Gln Leu Gly Glu Gly Asn Ile Met 
            100                 105                 110         


Glu Met Tyr Asn Lys Lys Glu Pro Val Lys Ala Ser Leu Phe Tyr His 
        115                 120                 125             


Lys Lys Ser Gly Thr Thr Ser Thr Phe Glu Ser Ala Ala Phe Pro Gly 
    130                 135                 140                 


Trp Phe Ile Ala Val Cys Ser Lys Gly Ser Cys Pro Leu Ile Leu Thr 
145                 150                 155                 160 


Gln Glu Leu Gly Glu Ile Phe Ile Thr Asp Phe Glu Met Ile Val Val 
                165                 170                 175     


His 
    


<210>  27
<211>  519
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Truncated IL-36 alpha

<400>  27
atggactgga cttggattct cttcctggtc gcagccgcta cacgggtgca ttcacgagcc       60

gcttcccctt cactgaggca tgtgcaggac ctgagcagca gggtgtggat tctgcagaac      120

aatattctca ccgctgtccc caggaaggag cagacagtgc ctgtcactat caccctgctc      180

ccatgccagt acctggacac actcgaaact aacaggggcg accccactta tatgggtgtg      240

cagagaccta tgtcttgcct gttctgtacc aaggatggag agcagcctgt cctgcagctc      300

ggagagggaa acatcatgga aatgtacaat aagaaggaac cagtgaaagc aagcctcttc      360

tatcacaaga aatcaggaac cacaagcaca tttgagtccg ccgctttccc aggctggttt      420

attgccgtgt gctctaaagg aagttgtccc ctgattctga cccaggaact gggggagatt      480

ttcattactg attttgagat gattgtcgtc cattgataa                             519


<210>  28
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Truncated IL-36 alpha

<400>  28

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Arg Ala Ala Ser Pro Ser Leu Arg His Val Gln Asp Leu Ser 
            20                  25                  30          


Ser Arg Val Trp Ile Leu Gln Asn Asn Ile Leu Thr Ala Val Pro Arg 
        35                  40                  45              


Lys Glu Gln Thr Val Pro Val Thr Ile Thr Leu Leu Pro Cys Gln Tyr 
    50                  55                  60                  


Leu Asp Thr Leu Glu Thr Asn Arg Gly Asp Pro Thr Tyr Met Gly Val 
65                  70                  75                  80  


Gln Arg Pro Met Ser Cys Leu Phe Cys Thr Lys Asp Gly Glu Gln Pro 
                85                  90                  95      


Val Leu Gln Leu Gly Glu Gly Asn Ile Met Glu Met Tyr Asn Lys Lys 
            100                 105                 110         


Glu Pro Val Lys Ala Ser Leu Phe Tyr His Lys Lys Ser Gly Thr Thr 
        115                 120                 125             


Ser Thr Phe Glu Ser Ala Ala Phe Pro Gly Trp Phe Ile Ala Val Cys 
    130                 135                 140                 


Ser Lys Gly Ser Cys Pro Leu Ile Leu Thr Gln Glu Leu Gly Glu Ile 
145                 150                 155                 160 


Phe Ile Thr Asp Phe Glu Met Ile Val Val His 
                165                 170     


<210>  29
<211>  603
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Full length IL-36 beta

<400>  29
atggattgga cctggattct gttcctcgtc gccgccgcaa ctagagtgca ttctgccttc       60

ccccctcagt catgtgtgca tgtgctgccc cctaagagca tccagatgtg ggagcctaac      120

cacaatacca tgcatgggag ctcccagtcc ccaaggaact acagagtgca cgactctcag      180

cagatggtgt gggtcctgac aggtaatacc ctcacagccg tgccagctag taacaatgtg      240

aaacccgtca tcctgtcact cattgcttgc cgagacactg aattccagga tgtgaagaaa      300

gggaacctgg tctttctcgg tattaagaac agaaatctgt gtttctgctg tgtggagatg      360

gaagggaaac ccaccctgca gctcaaggag gtcgatatca tgaatctgta caaggaaagg      420

aaagcacaga aggccttcct gttttatcac ggcattgagg gatcaacaag cgtgttccag      480

tctgtcctgt accctggctg gtttatcgcc acttctagta ttgaacggca gactatcatt      540

ctgacccatc agcgcggaaa actcgtgaac acaaacttct acatcgagag cgaaaagtga      600

taa                                                                    603


<210>  30
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Full length IL-36 beta

<400>  30

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Met Ala Phe Pro Pro Gln Ser Cys Val His Val Leu Pro Pro 
            20                  25                  30          


Lys Ser Ile Gln Met Trp Glu Pro Asn His Asn Thr Met His Gly Ser 
        35                  40                  45              


Ser Gln Ser Pro Arg Asn Tyr Arg Val His Asp Ser Gln Gln Met Val 
    50                  55                  60                  


Trp Val Leu Thr Gly Asn Thr Leu Thr Ala Val Pro Ala Ser Asn Asn 
65                  70                  75                  80  


Val Lys Pro Val Ile Leu Ser Leu Ile Ala Cys Arg Asp Thr Glu Phe 
                85                  90                  95      


Gln Asp Val Lys Lys Gly Asn Leu Val Phe Leu Gly Ile Lys Asn Arg 
            100                 105                 110         


Asn Leu Cys Phe Cys Cys Val Glu Met Glu Gly Lys Pro Thr Leu Gln 
        115                 120                 125             


Leu Lys Glu Val Asp Ile Met Asn Leu Tyr Lys Glu Arg Lys Ala Gln 
    130                 135                 140                 


Lys Ala Phe Leu Phe Tyr His Gly Ile Glu Gly Ser Thr Ser Val Phe 
145                 150                 155                 160 


Gln Ser Val Leu Tyr Pro Gly Trp Phe Ile Ala Thr Ser Ser Ile Glu 
                165                 170                 175     


Arg Gln Thr Ile Ile Leu Thr His Gln Arg Gly Lys Leu Val Asn Thr 
            180                 185                 190         


Asn Phe Tyr Ile Glu Ser Glu Lys 
        195                 200 


<210>  31
<211>  519
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Truncated IL-36 beta

<400>  31
atggactgga cttggattct cttcctggtc gccgcagcaa cacgagtgca ttcctcctca       60

cagagccccc gcaactatcg agtgcatgac tcccagcaga tggtgtgggt cctgacaggc      120

aacaccctca cagccgtgcc cgcttcaaac aatgtgaaac ctgtcatcct gagcctcatt      180

gcttgcaggg acactgagtt ccaggatgtg aagaaaggga atctggtctt tctcggtatt      240

aagaacagaa acctgtgctt ctgctgcgtg gagatggaag gcaaaccaac cctgcagctc      300

aaggaggtgg atattatgaa cctgtacaag gaacggaaag cacagaaggc cttcctcttt      360

tatcacggca tcgagggcag caccagcgtg ttccagagtg tcctgtaccc cggatggttt      420

atcgccacta gctccattga aaggcagacc atcatcctga cccaccagag aggcaaactc      480

gtgaatacaa acttctacat tgaaagcgaa aaatgataa                             519


<210>  32
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Truncated IL-36 beta

<400>  32

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Ser Gln Ser Pro Arg Asn Tyr Arg Val His Asp Ser Gln 
            20                  25                  30          


Gln Met Val Trp Val Leu Thr Gly Asn Thr Leu Thr Ala Val Pro Ala 
        35                  40                  45              


Ser Asn Asn Val Lys Pro Val Ile Leu Ser Leu Ile Ala Cys Arg Asp 
    50                  55                  60                  


Thr Glu Phe Gln Asp Val Lys Lys Gly Asn Leu Val Phe Leu Gly Ile 
65                  70                  75                  80  


Lys Asn Arg Asn Leu Cys Phe Cys Cys Val Glu Met Glu Gly Lys Pro 
                85                  90                  95      


Thr Leu Gln Leu Lys Glu Val Asp Ile Met Asn Leu Tyr Lys Glu Arg 
            100                 105                 110         


Lys Ala Gln Lys Ala Phe Leu Phe Tyr His Gly Ile Glu Gly Ser Thr 
        115                 120                 125             


Ser Val Phe Gln Ser Val Leu Tyr Pro Gly Trp Phe Ile Ala Thr Ser 
    130                 135                 140                 


Ser Ile Glu Arg Gln Thr Ile Ile Leu Thr His Gln Arg Gly Lys Leu 
145                 150                 155                 160 


Val Asn Thr Asn Phe Tyr Ile Glu Ser Glu Lys 
                165                 170     


<210>  33
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Full length IL-36 gamma

<400>  33
atggactgga catggattct gttcctggtc gctgctgcta cacgggtgca ttctgaaaat       60

aatgaaaaga aaaatatcgt ctacggctct gacgtggaga tggaacacga gcgagcagga      120

ctgttcgtca gctccgctat gttcagtaag cacccctttt caacccatat cagcggccgg      180

gaaacacctg atttcggaga ggtgtttgac ctcgatcagc aggtctggat ttttcgcaat      240

caggctctgg tgacagtccc taggagtcac agagtgacac cagtgtcagt cactatcctc      300

ccatgcaagt accccgaatc tctggagcag gacaaaggga tcgccatcta cctgggtatt      360

cagaatcctg ataagtgcct gttctgtaaa gaagtgaacg ggcatccaac cctgctcctg      420

aaggaggaaa aaatcctcga cctgtaccac catcccgaac ctatgaagcc cttcctgttt      480

tatcacacca gaacaggcgg aacttccacc ttcgagtctg tggcatttcc agggcattac      540

atcgcctcta gtaagactgg taaccccatt ttcctcacca gcaagaaagg agagtactac      600

aacatcaact tcaacctgga tatcaagtcc tgataa                                636


<210>  34
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Full length IL-36 gamma

<400>  34

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Phe Ser Lys His Pro Phe Ser Thr His Ile Ser Gly Arg Glu 
            20                  25                  30          


Thr Pro Asp Phe Gly Glu Val Phe Asp Leu Asp Gln Gln Val Trp Ile 
        35                  40                  45              


Phe Arg Asn Gln Ala Leu Val Thr Val Pro Arg Ser His Arg Val Thr 
    50                  55                  60                  


Pro Val Ser Val Thr Ile Leu Pro Cys Lys Tyr Pro Glu Ser Leu Glu 
65                  70                  75                  80  


Gln Asp Lys Gly Ile Ala Ile Tyr Leu Gly Ile Gln Asn Pro Asp Lys 
                85                  90                  95      


Cys Leu Phe Cys Lys Glu Val Asn Gly His Pro Thr Leu Leu Leu Lys 
            100                 105                 110         


Glu Glu Lys Ile Leu Asp Leu Tyr His His Pro Glu Pro Met Lys Pro 
        115                 120                 125             


Phe Leu Phe Tyr His Thr Arg Thr Gly Gly Thr Ser Thr Phe Glu Ser 
    130                 135                 140                 


Val Ala Phe Pro Gly His Tyr Ile Ala Ser Ser Lys Thr Gly Asn Pro 
145                 150                 155                 160 


Ile Phe Leu Thr Ser Lys Lys Gly Glu Tyr Tyr Asn Ile Asn Phe Asn 
                165                 170                 175     


Leu Asp Ile Lys Ser 
            180     


<210>  35
<211>  516
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Truncated IL-36 gamma

<400>  35
atggattgga catggattct gtttctggtc gccgccgcta caagagtgca tagtggacgg       60

gagacacctg atttcgggga agtgtttgac ctcgatcagc aagtgtggat cttccggaac      120

caggcactgg tgaccgtccc taggtcacac agagtcacac cagtgagcgt cactatcctc      180

ccatgcaagt accccgagtc tctggaacag gacaaaggga tcgccatcta cctgggtatt      240

cagaaccctg ataagtgcct gttttgtaaa gaagtgaatg gccatcccac cctgctcctg      300

aaggaggaaa aaattctcga cctgtaccac catcccgagc ctatgaagcc cttcctgttt      360

tatcacacca ggacaggcgg aacttctacc ttcgaaagtg tggcctttcc cggccattac      420

atcgctagct ccaaaacagg aaatcctatt ttcctgacaa gcaaaaaggg agaatactac      480

aacattaact tcaacctgga catcaaatct tgataa                                516


<210>  36
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Truncated IL-36 gamma

<400>  36

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Arg Glu Thr Pro Asp Phe Gly Glu Val Phe Asp Leu Asp 
            20                  25                  30          


Gln Gln Val Trp Ile Phe Arg Asn Gln Ala Leu Val Thr Val Pro Arg 
        35                  40                  45              


Ser His Arg Val Thr Pro Val Ser Val Thr Ile Leu Pro Cys Lys Tyr 
    50                  55                  60                  


Pro Glu Ser Leu Glu Gln Asp Lys Gly Ile Ala Ile Tyr Leu Gly Ile 
65                  70                  75                  80  


Gln Asn Pro Asp Lys Cys Leu Phe Cys Lys Glu Val Asn Gly His Pro 
                85                  90                  95      


Thr Leu Leu Leu Lys Glu Glu Lys Ile Leu Asp Leu Tyr His His Pro 
            100                 105                 110         


Glu Pro Met Lys Pro Phe Leu Phe Tyr His Thr Arg Thr Gly Gly Thr 
        115                 120                 125             


Ser Thr Phe Glu Ser Val Ala Phe Pro Gly His Tyr Ile Ala Ser Ser 
    130                 135                 140                 


Lys Thr Gly Asn Pro Ile Phe Leu Thr Ser Lys Lys Gly Glu Tyr Tyr 
145                 150                 155                 160 


Asn Ile Asn Phe Asn Leu Asp Ile Lys Ser 
                165                 170 


<210>  37
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, IgE leader sequence

<400>  37

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


