                         SEQUENCE LISTING

<110>  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
       THE CHILDREN'S HOSPITAL OF PHILADELPHIA
       THE GOVERNMENT OF THE UNITED STATES OF AMERICA as 
       represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND 
       HUMAN SERVICES
       Heitzeneder, Sabine
       Majzner, Robbie G.
       Mackall, Crystal  L.
       Maris, John M.
       Bosse, Kristopher R.
       Dimitrov, Dimiter S.
 
<120>  Chimeric Antigen Receptors Targeting Glypican-2

<130>  078430-507001WO

<140>  Herewith
<141>  Herewith

<150>  US 62/844,695
<151>  2019-05-07

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  HCDR1 - scFv.19

<400>  1

Gly Gly Ser Ile Ser Ser Ser Ser Tyr Tyr 
1               5                   10  


<210>  2
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  HCDR2 - scFv.19

<400>  2

Ile Tyr Tyr Ser Gly Ser Thr Tyr 
1               5               


<210>  3
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  HCDR3 - scFv.19

<400>  3

Ala Arg Arg Val Ser Gly His Pro Phe Asp Pro 
1               5                   10      

<210>  4
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  LCDR1 - scFv.19

<400>  4

Gln Asp Ile Ser Asp Tyr 
1               5       


<210>  5
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  LCDR2 - scFv.19

<400>  5

Asp Ala Ser 
1           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  LCDR3 - scFv.19

<400>  6

Gln Gln Tyr Asp Asn Leu Pro Ile Thr 
1               5                   


<210>  7
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  VH - scFv.19

<400>  7

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Val Ser Gly His Pro Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  8
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  VL- scFv.19

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asp Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  9
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  HCDR1 - scFv.27

<400>  9

Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr 
1               5                   


<210>  10
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  HCDR2 - scFv.27

<400>  10

Ile Tyr His Ser Gly Ser Thr Tyr 
1               5               


<210>  11
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  HCDR3 - scFv.27

<400>  11

Ala Ser Leu Pro Ser Arg Gly Gly Phe Asp Tyr 
1               5                   10      


<210>  12
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  LCDR1 - scFv.27

<400>  12

Gln Thr Ile Ser Arg Tyr 
1               5       


<210>  13
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  LCDR2 - scFv.27

<400>  13

Ala Ala Ser 
1           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  LCDR3 - scFv.27

<400>  14

Gln Gln Thr Tyr Ser Pro Pro Ile Thr 
1               5                   


<210>  15
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  VH - scFv.27

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Pro Ser Arg Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  16
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  VL- scFv.27

<400>  16

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Gln Thr Ile Ser Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Thr Tyr Ser Pro Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
            100                 105             


<210>  17
<211>  488
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  19VLVH.8aH-8aTM.41BBz

<400>  17

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Asp Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Asp Asn Leu Pro Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser 
                165                 170                 175     


Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro 
        195                 200                 205             


Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 
    210                 215                 220                 


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Arg Val Ser Gly His Pro Phe Asp Pro Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Ala Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  18
<211>  488
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  19VLVH.CH2CH3.8aH-8aTM.41BBz

<400>  18

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Asp Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Asp Asn Leu Pro Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser 
                165                 170                 175     


Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro 
        195                 200                 205             


Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 
    210                 215                 220                 


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Arg Val Ser Gly His Pro Phe Asp Pro Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Ala Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  19
<211>  487
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  19.VLVH.28TM.41BBz

<400>  19

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Asp Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Asp Asn Leu Pro Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser 
                165                 170                 175     


Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro 
        195                 200                 205             


Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 
    210                 215                 220                 


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Arg Val Ser Gly His Pro Phe Asp Pro Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Ile Glu Val Met Tyr 
            260                 265                 270         


Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His 
        275                 280                 285             


Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser 
    290                 295                 300                 


Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
305                 310                 315                 320 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  20
<211>  486
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  19VLVH.28TM.28z

<400>  20

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Asp Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Asp Asn Leu Pro Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser 
                165                 170                 175     


Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro 
        195                 200                 205             


Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 
    210                 215                 220                 


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Arg Val Ser Gly His Pro Phe Asp Pro Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Ile Glu Val Met Tyr 
            260                 265                 270         


Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His 
        275                 280                 285             


Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser 
    290                 295                 300                 


Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
305                 310                 315                 320 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
                325                 330                 335     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            340                 345                 350         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        355                 360                 365             


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  21
<211>  242
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  GPC2.19 (VH-linker-VL)_amino acid

<400>  21

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Val Ser Gly His Pro Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asp Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asp Asn Leu Pro Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Arg 
        


<210>  22
<211>  241
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  GPC2.27 (VH-linker-VL) amino acid

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Pro Ser Arg Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Thr Ile Ser Arg Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Ser 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Thr 
    210                 215                 220                 


Tyr Ser Pro Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
225                 230                 235                 240 


Arg 
    


<210>  23
<211>  488
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  19VHVL.8aH-8aTM.41BBz

<400>  23

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser 
65                  70                  75                  80  


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Val Ser Gly His Pro Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Ala Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asp Tyr Leu Asn Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
        195                 200                 205             


Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile Thr Phe Gly Gln 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys Arg Ala Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  24
<211>  487
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  27VLVH.8aH-8aTM.41BBz

<400>  24

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ala Cys Arg Ala Ser 
        35                  40                  45              


Gln Thr Ile Ser Arg Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Thr Tyr Ser Pro Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser 
                165                 170                 175     


Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
        195                 200                 205             


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
    210                 215                 220                 


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Ala Ser Leu Pro Ser Arg Gly Gly Phe Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser Ala Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  25
<211>  487
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  27VHVL.8aH-8aTM.41BBz

<400>  25

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly 
        35                  40                  45              


Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr His Ser Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Ser Leu Pro Ser Arg Gly Gly Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ala Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Ala Cys Arg Ala Ser Gln Thr Ile Ser Arg Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Phe Cys Gln Gln Thr Tyr Ser Pro Pro Ile Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Arg Leu Glu Ile Lys Arg Ala Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  26
<211>  1467
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  encodes the polypeptide of SEQ ID NO:17


<220>
<221>  misc_feature
<223>  19VLVH.8aH-8aTM.41BBz

<400>  26
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccagaca tccagatgac ccagtctcca tcctccctgt ctgcatctat aggagacaga      120

gtcaccatca cttgccaggc gagtcaggac attagcgact atttaaattg gtatcagcag      180

aaaccaggga aagcccctaa gctcctgatc tacgatgcat ccaatttgga gactggggtc      240

ccatcaaggt tcagtggaag tggatctggg acagatttta ctttcaccat cagcagcctc      300

cagcctgaag atgttgcaac atattactgt caacagtatg ataatctccc gatcaccttc      360

ggccaaggga ccaagctgga aatcaaacgt ggaggtggcg ggtctggtgg aggcgctagc      420

ggtggtggcg gatcccagct gcagctgcag gagtcgggcc caggactggt gaagccttcg      480

gagaccctgt ccctcacctg cactgtctct ggtggctcca tcagcagtag tagttactac      540

tggagctgga tccgccagcc cccagggaag gggctggagt ggattgggag tatctattat      600

agtgggagca cctactacaa cccgtccctc aagagtcgag tcaccatatc agtagacacg      660

tccaagaacc agttctccct gaagctgagc tctgtgaccg ccgcggacac ggccgtgtat      720

tactgtgcga gacgggtcag tggccacccc ttcgacccct ggggccaggg aaccctggtc      780

accgtctcct cagcaaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa     1020

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1080

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc     1140

agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc     1200

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1260

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgctaa                                         1467


<210>  27
<211>  2160
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  encodes the polypeptide of SEQ ID NO:18

<220>
<221>  misc_feature
<223>  19VLVH.CH2CH3.8aH-8aTM.41BBz

<400>  27
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccagaca tccagatgac ccagtctcca tcctccctgt ctgcatctat aggagacaga      120

gtcaccatca cttgccaggc gagtcaggac attagcgact atttaaattg gtatcagcag      180

aaaccaggga aagcccctaa gctcctgatc tacgatgcat ccaatttgga gactggggtc      240

ccatcaaggt tcagtggaag tggatctggg acagatttta ctttcaccat cagcagcctc      300

cagcctgaag atgttgcaac atattactgt caacagtatg ataatctccc gatcaccttc      360

ggccaaggga ccaagctgga aatcaaacgt ggaggtggcg ggtctggtgg aggcgctagc      420

ggtggtggcg gatcccagct gcagctgcag gagtcgggcc caggactggt gaagccttcg      480

gagaccctgt ccctcacctg cactgtctct ggtggctcca tcagcagtag tagttactac      540

tggagctgga tccgccagcc cccagggaag gggctggagt ggattgggag tatctattat      600

agtgggagca cctactacaa cccgtccctc aagagtcgag tcaccatatc agtagacacg      660

tccaagaacc agttctccct gaagctgagc tctgtgaccg ccgcggacac ggccgtgtat      720

tactgtgcga gacgggtcag tggccacccc ttcgacccct ggggccaggg aaccctggtc      780

accgtctcct cagagtccaa atatggtccc ccatgcccat catgcccagc acctccggtc      840

gcgggaccat cagtcttcct gttcccccca aaacccaagg acactctcat gatctcccgg      900

acccctgagg tcacgtgcgt ggtggtggac gtgagccagg aagaccccga ggtccagttc      960

aactggtacg tggatggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1020

ttccaaagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaac     1080

ggcaaggagt acaagtgcaa ggtctccaac aaaggcctcc cgtcctccat cgagaaaacc     1140

atctccaaag ccaaagggca gccccgagag ccacaggtgt acaccctgcc cccatcccag     1200

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc     1260

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1320

cccgtgctgg actccgacgg ctccttcttc ctctacagca ggctcaccgt ggacaagagc     1380

aggtggcagg aggggaatgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1440

tacacacaga agagcctctc cctgtctctg ggtaaatcgg cggccgcaac cacgacgcca     1500

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca     1560

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt     1620

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt     1680

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1740

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1800

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1860

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1920

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1980

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     2040

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     2100

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgctaa     2160


<210>  28
<211>  1464
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  encodes the polypeptide of SEQ ID NO:19


<220>
<221>  misc_feature
<223>  19.VLVH.28TM.41BBz

<400>  28
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccagaca tccagatgac ccagtctcca tcctccctgt ctgcatctat aggagacaga      120

gtcaccatca cttgccaggc gagtcaggac attagcgact atttaaattg gtatcagcag      180

aaaccaggga aagcccctaa gctcctgatc tacgatgcat ccaatttgga gactggggtc      240

ccatcaaggt tcagtggaag tggatctggg acagatttta ctttcaccat cagcagcctc      300

cagcctgaag atgttgcaac atattactgt caacagtatg ataatctccc gatcaccttc      360

ggccaaggga ccaagctgga aatcaaacgt ggaggtggcg ggtctggtgg aggcgctagc      420

ggtggtggcg gatcccagct gcagctgcag gagtcgggcc caggactggt gaagccttcg      480

gagaccctgt ccctcacctg cactgtctct ggtggctcca tcagcagtag tagttactac      540

tggagctgga tccgccagcc cccagggaag gggctggagt ggattgggag tatctattat      600

agtgggagca cctactacaa cccgtccctc aagagtcgag tcaccatatc agtagacacg      660

tccaagaacc agttctccct gaagctgagc tctgtgaccg ccgcggacac ggccgtgtat      720

tactgtgcga gacgggtcag tggccacccc ttcgacccct ggggccaggg aaccctggtc      780

accgtctcct cagcggccgc aattgaagtt atgtatcctc ctccttacct agacaatgag      840

aagagcaatg gaaccattat ccatgtgaaa gggaaacacc tttgtccaag tcccctattt      900

cccggacctt ctaagccctt ttgggtgctg gtggtggttg ggggagtcct ggcttgctat      960

agcttgctag taacagtggc ctttattatt ttctgggtga aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg ctaa                                            1464


<210>  29
<211>  1461
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  encodes the polypeptide of SEQ ID NO:20


<220>
<221>  misc_feature
<223>  19VLVH.28TM.28z

<400>  29
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccagaca tccagatgac ccagtctcca tcctccctgt ctgcatctat aggagacaga      120

gtcaccatca cttgccaggc gagtcaggac attagcgact atttaaattg gtatcagcag      180

aaaccaggga aagcccctaa gctcctgatc tacgatgcat ccaatttgga gactggggtc      240

ccatcaaggt tcagtggaag tggatctggg acagatttta ctttcaccat cagcagcctc      300

cagcctgaag atgttgcaac atattactgt caacagtatg ataatctccc gatcaccttc      360

ggccaaggga ccaagctgga aatcaaacgt ggaggtggcg ggtctggtgg aggcgctagc      420

ggtggtggcg gatcccagct gcagctgcag gagtcgggcc caggactggt gaagccttcg      480

gagaccctgt ccctcacctg cactgtctct ggtggctcca tcagcagtag tagttactac      540

tggagctgga tccgccagcc cccagggaag gggctggagt ggattgggag tatctattat      600

agtgggagca cctactacaa cccgtccctc aagagtcgag tcaccatatc agtagacacg      660

tccaagaacc agttctccct gaagctgagc tctgtgaccg ccgcggacac ggccgtgtat      720

tactgtgcga gacgggtcag tggccacccc ttcgacccct ggggccaggg aaccctggtc      780

accgtctcct cagcggccgc aattgaagtt atgtatcctc ctccttacct agacaatgag      840

aagagcaatg gaaccattat ccatgtgaaa gggaaacacc tttgtccaag tcccctattt      900

cccggacctt ctaagccctt ttgggtgctg gtggtggttg ggggagtcct ggcttgctat      960

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc     1020

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac     1080

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta a                                               1461


<210>  30
<211>  1467
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  encodes the polypeptide of SEQ ID NO:23

<220>
<221>  misc_feature
<223>  19VHVL.8aH-8aTM.41BBz

<400>  30
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccacagc tgcagctgca ggagtcgggc ccaggactgg tgaagccttc ggagaccctg      120

tccctcacct gcactgtctc tggtggctcc atcagcagta gtagttacta ctggagctgg      180

atccgccagc ccccagggaa ggggctggag tggattggga gtatctatta tagtgggagc      240

acctactaca acccgtccct caagagtcga gtcaccatat cagtagacac gtccaagaac      300

cagttctccc tgaagctgag ctctgtgacc gccgcggaca cggccgtgta ttactgtgcg      360

agacgggtca gtggccaccc cttcgacccc tggggccagg gaaccctggt caccgtctcc      420

tcaggaggtg gcgggtctgg tggaggcgct agcggtggtg gcggatccga catccagatg      480

acccagtctc catcctccct gtctgcatct ataggagaca gagtcaccat cacttgccag      540

gcgagtcagg acattagcga ctatttaaat tggtatcagc agaaaccagg gaaagcccct      600

aagctcctga tctacgatgc atccaatttg gagactgggg tcccatcaag gttcagtgga      660

agtggatctg ggacagattt tactttcacc atcagcagcc tccagcctga agatgttgca      720

acatattact gtcaacagta tgataatctc ccgatcacct tcggccaagg gaccaagctg      780

gaaatcaaac gtgcaaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa     1020

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1080

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc     1140

agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc     1200

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1260

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgctaa                                         1467


<210>  31
<211>  2160
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  encodes 19VHVL.CH2CH3.8aH-8aTM.41BBz

<400>  31
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccacagc tgcagctgca ggagtcgggc ccaggactgg tgaagccttc ggagaccctg      120

tccctcacct gcactgtctc tggtggctcc atcagcagta gtagttacta ctggagctgg      180

atccgccagc ccccagggaa ggggctggag tggattggga gtatctatta tagtgggagc      240

acctactaca acccgtccct caagagtcga gtcaccatat cagtagacac gtccaagaac      300

cagttctccc tgaagctgag ctctgtgacc gccgcggaca cggccgtgta ttactgtgcg      360

agacgggtca gtggccaccc cttcgacccc tggggccagg gaaccctggt caccgtctcc      420

tcaggaggtg gcgggtctgg tggaggcgct agcggtggtg gcggatccga catccagatg      480

acccagtctc catcctccct gtctgcatct ataggagaca gagtcaccat cacttgccag      540

gcgagtcagg acattagcga ctatttaaat tggtatcagc agaaaccagg gaaagcccct      600

aagctcctga tctacgatgc atccaatttg gagactgggg tcccatcaag gttcagtgga      660

agtggatctg ggacagattt tactttcacc atcagcagcc tccagcctga agatgttgca      720

acatattact gtcaacagta tgataatctc ccgatcacct tcggccaagg gaccaagctg      780

gaaatcaaac gtgagtccaa atatggtccc ccatgcccat catgcccagc acctccggtc      840

gcgggaccat cagtcttcct gttcccccca aaacccaagg acactctcat gatctcccgg      900

acccctgagg tcacgtgcgt ggtggtggac gtgagccagg aagaccccga ggtccagttc      960

aactggtacg tggatggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1020

ttccaaagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaac     1080

ggcaaggagt acaagtgcaa ggtctccaac aaaggcctcc cgtcctccat cgagaaaacc     1140

atctccaaag ccaaagggca gccccgagag ccacaggtgt acaccctgcc cccatcccag     1200

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc     1260

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1320

cccgtgctgg actccgacgg ctccttcttc ctctacagca ggctcaccgt ggacaagagc     1380

aggtggcagg aggggaatgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1440

tacacacaga agagcctctc cctgtctctg ggtaaatcgg cggccgcaac cacgacgcca     1500

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca     1560

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt     1620

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt     1680

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1740

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1800

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1860

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1920

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1980

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     2040

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     2100

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgctaa     2160


<210>  32
<211>  1464
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  encodes the polypeptide of SEQ ID NO:24

<220>
<221>  misc_feature
<223>  27VLVH.8aH-8aTM.41BBz

<400>  32
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccagaaa ttgtgatgac gcagtctcca gccaccctgt ctgcatctgt aggagacaga      120

gtcaccatcg cttgccgggc aagtcagacc attagtaggt atttaaattg gtatcagcag      180

aaaccaggga aagcccctaa gctcctgatc tatgcagcat ccagtttgca aagtggggtc      240

tcatcaaggt tcagtggcag tggatctggg acagagttca ctctcaccat cagcagtctg      300

cagcctgaag attttgcaac ttatttctgt caacagactt acagtccccc gatcaccttc      360

ggccaaggga cacgactgga gattaaacga ggaggtggcg ggtctggtgg aggcgctagc      420

ggtggtggcg gatccgaggt gcagctggtg gagtccggcc caggactggt gaagccttcg      480

gagaccctgt ccctcacctg cgctgtctct ggttactcca tcagcagtgg ttactactgg      540

ggctggatcc ggcagccccc agggaagggg ctggagtgga ttgggagtat ctatcatagt      600

gggagcacct actacaaccc gtccctcaag agtcgagtca ccatatcagt agacacgtcc      660

aagaaccagt tctccctgaa gctgagctct gtgaccgccg cagacacggc cgtgtattac      720

tgtgcgagtt tgccgagtcg ggggggtttt gactattggg gccagggcac cctggtcacc      780

gtctcctcag caaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg ctaa                                            1464


<210>  33
<211>  1464
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  encodes the polypeptide of SEQ ID NO:25

<220>
<221>  misc_feature
<223>  27VHVL.8aH-8aTM.41BBz

<400>  33
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccagagg tgcagctggt ggagtccggc ccaggactgg tgaagccttc ggagaccctg      120

tccctcacct gcgctgtctc tggttactcc atcagcagtg gttactactg gggctggatc      180

cggcagcccc cagggaaggg gctggagtgg attgggagta tctatcatag tgggagcacc      240

tactacaacc cgtccctcaa gagtcgagtc accatatcag tagacacgtc caagaaccag      300

ttctccctga agctgagctc tgtgaccgcc gcagacacgg ccgtgtatta ctgtgcgagt      360

ttgccgagtc gggggggttt tgactattgg ggccagggca ccctggtcac cgtctcctca      420

ggaggtggcg ggtctggtgg aggcgctagc ggtggtggcg gatccgaaat tgtgatgacg      480

cagtctccag ccaccctgtc tgcatctgta ggagacagag tcaccatcgc ttgccgggca      540

agtcagacca ttagtaggta tttaaattgg tatcagcaga aaccagggaa agcccctaag      600

ctcctgatct atgcagcatc cagtttgcaa agtggggtct catcaaggtt cagtggcagt      660

ggatctggga cagagttcac tctcaccatc agcagtctgc agcctgaaga ttttgcaact      720

tatttctgtc aacagactta cagtcccccg atcaccttcg gccaagggac acgactggag      780

attaaacgag caaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg ctaa                                            1464


