                         SEQUENCE LISTING

<110>  Synthetic Biologics, Inc.
 
<120>  ALKALINE PHOSPHATE-BASED ONCOLOGY TREATMENTS

<130>  SYN-046PC/112492-5046

<150>  US 62/843,850
<151>  2019-05-06

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  1

Met Gln Gly Pro Trp Val Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu 
1               5                   10                  15      


Ser Leu Gly Val Ile Pro Ala Glu Glu Glu Asn Pro Ala Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Glu Ala Leu Asp Ala Ala Lys Lys Leu Gln Pro Ile 
        35                  40                  45              


Gln Lys Val Ala Lys Asn Leu Ile Leu Phe Leu Gly Asp Gly Leu Gly 
    50                  55                  60                  


Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Lys Asn Gly 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Pro Leu Ala Met Asp Arg Phe Pro Tyr Leu 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala 
            100                 105                 110         


Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Phe Gln Thr 
        115                 120                 125             


Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg 
    130                 135                 140                 


Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys Gln Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Thr Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Met Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Ile Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Phe Pro Met Gly Thr Pro Asp Pro Glu Tyr Pro Ala Asp Ala 
225                 230                 235                 240 


Ser Gln Asn Gly Ile Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Leu Ala Lys His Gln Gly Ala Trp Tyr Val Trp Asn Arg Thr Glu Leu 
            260                 265                 270         


Met Gln Ala Ser Leu Asp Gln Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Gly Asp Thr Lys Tyr Glu Ile His Arg Asp Pro Thr Leu Asp 
    290                 295                 300                 


Pro Ser Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Arg Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Glu Gly Val Ala Tyr Gln Ala Leu Thr Glu Ala Val Met 
            340                 345                 350         


Phe Asp Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp 
        355                 360                 365             


Thr Leu Thr Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Thr Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Ser Lys 
385                 390                 395                 400 


Ala Gln Asp Ser Lys Ala Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Phe Asn Ser Gly Val Arg Pro Asp Val Asn Glu Ser Glu 
            420                 425                 430         


Ser Gly Ser Pro Asp Tyr Gln Gln Gln Ala Ala Val Pro Leu Ser Ser 
        435                 440                 445             


Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Gln Ser Phe Val Ala His Val 
465                 470                 475                 480 


Met Ala Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala 
                485                 490                 495     


Pro Pro Ala Cys Thr Thr Asp Ala Ala His Pro Val Ala Ala Ser Leu 
            500                 505                 510         


Pro Leu Leu Ala Gly Thr Leu Leu Leu Leu Gly Ala Ser Ala Ala Pro 
        515                 520                 525             


<210>  2
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  2

Met Gln Gly Ala Cys Val Leu Leu Leu Leu Gly Leu His Leu Gln Leu 
1               5                   10                  15      


Ser Leu Gly Leu Ile Pro Ala Glu Glu Glu Asn Pro Ala Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Gln Ala Leu Asp Val Ala Lys Lys Leu Gln Pro Ile 
        35                  40                  45              


Gln Thr Ala Ala Lys Asn Val Ile Leu Phe Leu Gly Asp Gly Met Gly 
    50                  55                  60                  


Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Met Asn Gly 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Pro Leu Ala Met Asp Gln Phe Pro Tyr Val 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala 
            100                 105                 110         


Gly Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Tyr Arg Thr 
        115                 120                 125             


Ile Gly Val Ser Ala Ala Ala Arg Tyr Asn Gln Cys Asn Thr Thr Arg 
    130                 135                 140                 


Gly Asn Glu Val Thr Ser Val Ile Asn Arg Ala Lys Lys Ala Gly Lys 
145                 150                 155                 160 


Ala Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Ala Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Leu Pro Ala Asp Ala Gln Lys Asn Gly Cys Gln Asp Ile Ala Ala Gln 
        195                 200                 205             


Leu Val Tyr Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Met 
    210                 215                 220                 


Tyr Met Phe Pro Glu Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Ala 
225                 230                 235                 240 


Ser Val Asn Gly Val Arg Lys Asp Lys Gln Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Gln Ala Lys His Gln Gly Ala Gln Tyr Val Trp Asn Arg Thr Ala Leu 
            260                 265                 270         


Leu Gln Ala Ala Asp Asp Ser Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Ala Asp Met Lys Tyr Asn Val Gln Gln Asp His Thr Lys Asp 
    290                 295                 300                 


Pro Thr Leu Ala Glu Met Thr Glu Ala Ala Leu Gln Val Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Arg Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Asp Gly Lys Ala Tyr Met Ala Leu Thr Glu Ala Ile Met 
            340                 345                 350         


Phe Asp Asn Ala Ile Ala Lys Ala Asn Glu Leu Thr Ser Glu Leu Asp 
        355                 360                 365             


Thr Leu Ile Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Thr Leu Arg Gly Thr Ser Ile Phe Gly Leu Ala Pro Gly Lys 
385                 390                 395                 400 


Ala Leu Asp Ser Lys Ser Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Ala Leu 
            420 


<210>  3
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  3

Met Gln Trp Ala Cys Val Leu Leu Leu Leu Gly Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Leu Thr Phe Ile Pro Ala Glu Glu Glu Asp Pro Ala Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Gln Ala Leu Asp Val Ala Lys Lys Leu Gln Pro Ile 
        35                  40                  45              


Gln Thr Ala Ala Lys Asn Val Ile Leu Phe Leu Gly Asp Gly Met Gly 
    50                  55                  60                  


Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Met Asn Gly 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Pro Leu Ala Met Asp Gln Phe Pro Tyr Val 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala 
            100                 105                 110         


Gly Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Tyr Lys Thr 
        115                 120                 125             


Ile Gly Val Ser Ala Ala Ala Arg Tyr Asn Gln Cys Asn Thr Thr Ser 
    130                 135                 140                 


Gly Asn Glu Val Thr Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Ser Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Ala Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Leu Pro Ala Asp Ala Gln Thr Tyr Gly Cys Gln Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Val Asn Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Met 
    210                 215                 220                 


Tyr Met Phe Pro Glu Gly Thr Pro Asp Pro Glu Tyr Pro Tyr Asp Val 
225                 230                 235                 240 


Asn Gln Thr Gly Val Arg Lys Asp Lys Arg Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Gln Ala Lys His Gln Gly Ala Gln Tyr Val Trp Asn Arg Thr Glu Leu 
            260                 265                 270         


Leu Gln Ala Ala Asn Asp Pro Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Ala Asp Met Lys Tyr Asn Val Gln Gln Asp Pro Thr Lys Asp 
    290                 295                 300                 


Pro Thr Leu Glu Glu Met Thr Glu Ala Ala Leu Gln Val Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Gln Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Glu Gly Lys Ala Tyr Met Ala Leu Thr Asp Thr Val Met 
            340                 345                 350         


Phe Asp Asn Ala Ile Ala Lys Ala Asn Glu Leu Thr Ser Glu Leu Asp 
        355                 360                 365             


Thr Leu Ile Leu Ala Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Thr Leu Arg Gly Thr Ser Ile Phe Gly Leu Ala Pro Ser Lys 
385                 390                 395                 400 


Ala Ser Asp Asn Lys Ser Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Leu Gly Gly Gly Leu Arg Pro Asp Val Asn Asp Ser Ile 
            420                 425                 430         


Ser Glu Asp Pro Ser Tyr Arg Gln Gln Ala Ala Val Pro Leu Ser Ser 
        435                 440                 445             


Glu Ser His Gly Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Glu Thr Phe Val Ala His Val 
465                 470                 475                 480 


Met Ala Phe Ala Gly Cys Val Glu Pro Tyr Thr Asp Cys Asn Leu Pro 
                485                 490                 495     


Ala Pro Ser Gly Leu Ser Asp Ala Ala His Leu Ala Ala Ser Pro Pro 
            500                 505                 510         


Ser Leu Ala Leu Leu Ala Gly Ala Met Leu Leu Leu Leu Ala Pro Ala 
        515                 520                 525             


Leu Tyr 
    530 


<210>  4
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  4

Met Gln Gly Pro Trp Val Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu 
1               5                   10                  15      


Ser Leu Gly Val Ile Pro Ala Glu Glu Glu Asn Pro Ala Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Glu Ala Leu Asp Ala Ala Lys Lys Leu Gln Pro Ile 
        35                  40                  45              


Gln Lys Val Ala Lys Asn Leu Ile Leu Phe Leu Gly Asp Gly Leu Gly 
    50                  55                  60                  


Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Lys Asn Gly 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Pro Leu Ala Met Asp Arg Phe Pro Tyr Leu 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala 
            100                 105                 110         


Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Phe Gln Thr 
        115                 120                 125             


Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg 
    130                 135                 140                 


Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys Gln Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Thr Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Met Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Ile Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Phe Pro Met Gly Thr Pro Asp Pro Glu Tyr Pro Ala Asp Ala 
225                 230                 235                 240 


Ser Gln Asn Gly Ile Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Leu Ala Lys His Gln Gly Ala Trp Tyr Val Trp Asn Arg Thr Glu Leu 
            260                 265                 270         


Met Gln Ala Ser Leu Asp Gln Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Gly Asp Thr Lys Tyr Glu Ile His Arg Asp Pro Thr Leu Asp 
    290                 295                 300                 


Pro Ser Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Arg Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Glu Gly Val Ala Tyr Gln Ala Leu Thr Glu Ala Val Met 
            340                 345                 350         


Phe Asp Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp 
        355                 360                 365             


Thr Leu Thr Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Thr Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Ser Lys 
385                 390                 395                 400 


Ala Gln Asp Ser Lys Ala Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Phe Asn Ser Gly Val Arg Pro Asp Val Asn Glu Ser Glu 
            420                 425                 430         


Ser Gly Ser Pro Asp Tyr Gln Gln Gln Ala Ala Val Pro Leu Ser Ser 
        435                 440                 445             


Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Gln Ser Phe Val Ala His Val 
465                 470                 475                 480 


Met Ala Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala 
                485                 490                 495     


Pro Pro Ala Gly Thr Thr Asp 
            500             


<210>  5
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  5

Met Gln Gly Ala Cys Val Leu Leu Leu Leu Gly Leu His Leu Gln Leu 
1               5                   10                  15      


Ser Leu Gly Leu Ile Pro Ala Glu Glu Glu Asn Pro Ala Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Gln Ala Leu Asp Val Ala Lys Lys Leu Gln Pro Ile 
        35                  40                  45              


Gln Thr Ala Ala Lys Asn Val Ile Leu Phe Leu Gly Asp Gly Met Gly 
    50                  55                  60                  


Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Met Asn Gly 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Pro Leu Ala Met Asp Gln Phe Pro Tyr Val 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala 
            100                 105                 110         


Gly Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Tyr Arg Thr 
        115                 120                 125             


Ile Gly Val Ser Ala Ala Ala Arg Tyr Asn Gln Cys Asn Thr Thr Arg 
    130                 135                 140                 


Gly Asn Glu Val Thr Ser Val Ile Asn Arg Ala Lys Lys Ala Gly Lys 
145                 150                 155                 160 


Ala Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Ala Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Leu Pro Ala Asp Ala Gln Lys Asn Gly Cys Gln Asp Ile Ala Ala Gln 
        195                 200                 205             


Leu Val Tyr Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Met 
    210                 215                 220                 


Tyr Met Phe Pro Glu Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Ala 
225                 230                 235                 240 


Ser Val Asn Gly Val Arg Lys Asp Lys Gln Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Gln Ala Lys His Gln Gly Ala Gln Tyr Val Trp Asn Arg Thr Ala Leu 
            260                 265                 270         


Leu Gln Ala Ala Asp Asp Ser Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Ala Asp Met Lys Tyr Asn Val Gln Gln Asp His Thr Lys Asp 
    290                 295                 300                 


Pro Thr Leu Ala Glu Met Thr Glu Ala Ala Leu Gln Val Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Arg Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Asp Gly Lys Ala Tyr Met Ala Leu Thr Glu Ala Ile Met 
            340                 345                 350         


Phe Asp Asn Ala Ile Ala Lys Ala Asn Glu Leu Thr Ser Glu Leu Asp 
        355                 360                 365             


Thr Leu Ile Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Thr Leu Arg Gly Thr Ser Ile Phe Gly Leu Ala Pro Gly Lys 
385                 390                 395                 400 


Ala Leu Asp Ser Lys Ser Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Ala Leu Gly Gly Gly Ser Arg Pro Asp Val Asn Gly Ser Thr 
            420                 425                 430         


Ser Glu Glu Pro Ser Tyr Arg Gln Gln Ala Ala Val Pro Leu Ala Ser 
        435                 440                 445             


Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Glu Thr Phe Val Ala His Ile 
465                 470                 475                 480 


Met Ala Phe Ala Gly Cys Val Glu Pro Tyr Thr Asp Cys Asn Leu Pro 
                485                 490                 495     


Ala Pro Ala Thr Ala Thr Ser Ile Pro Asp 
            500                 505     


<210>  6
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  6

Met Gln Trp Ala Cys Val Leu Leu Leu Leu Gly Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Leu Thr Phe Ile Pro Ala Glu Glu Glu Asp Pro Ala Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Gln Ala Leu Asp Val Ala Lys Lys Leu Gln Pro Ile 
        35                  40                  45              


Gln Thr Ala Ala Lys Asn Val Ile Leu Phe Leu Gly Asp Gly Met Gly 
    50                  55                  60                  


Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Met Asn Gly 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Pro Leu Ala Met Asp Gln Phe Pro Tyr Val 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala 
            100                 105                 110         


Gly Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Tyr Lys Thr 
        115                 120                 125             


Ile Gly Val Ser Ala Ala Ala Arg Tyr Asn Gln Cys Asn Thr Thr Ser 
    130                 135                 140                 


Gly Asn Glu Val Thr Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Ser Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Ala Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Leu Pro Ala Asp Ala Gln Thr Tyr Gly Cys Gln Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Val Asn Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Met 
    210                 215                 220                 


Tyr Met Phe Pro Glu Gly Thr Pro Asp Pro Glu Tyr Pro Tyr Asp Val 
225                 230                 235                 240 


Asn Gln Thr Gly Val Arg Lys Asp Lys Arg Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Gln Ala Lys His Gln Gly Ala Gln Tyr Val Trp Asn Arg Thr Glu Leu 
            260                 265                 270         


Leu Gln Ala Ala Asn Asp Pro Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Ala Asp Met Lys Tyr Asn Val Gln Gln Asp Pro Thr Lys Asp 
    290                 295                 300                 


Pro Thr Leu Glu Glu Met Thr Glu Ala Ala Leu Gln Val Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Gln Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Glu Gly Lys Ala Tyr Met Ala Leu Thr Asp Thr Val Met 
            340                 345                 350         


Phe Asp Asn Ala Ile Ala Lys Ala Asn Glu Leu Thr Ser Glu Leu Asp 
        355                 360                 365             


Thr Leu Ile Leu Ala Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Thr Leu Arg Gly Thr Ser Ile Phe Gly Leu Ala Pro Ser Lys 
385                 390                 395                 400 


Ala Ser Asp Asn Lys Ser Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Leu Gly Gly Gly Leu Arg Pro Asp Val Asn Asp Ser Ile 
            420                 425                 430         


Ser Glu Asp Pro Ser Tyr Arg Gln Gln Ala Ala Val Pro Leu Ser Ser 
        435                 440                 445             


Glu Ser His Gly Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Glu Thr Phe Val Ala His Val 
465                 470                 475                 480 


Met Ala Phe Ala Gly Cys Val Glu Pro Tyr Thr Asp Cys Asn Leu Pro 
                485                 490                 495     


Ala Pro Ser Gly Leu Ser Asp 
            500             


<210>  7
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  7

Met Gln Trp Ala Cys Val Leu Leu Leu Leu Gly Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Leu Thr Phe Ile Pro Ala Glu Glu Glu Asp Pro Ala Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Gln Ala Leu Asp Val Ala Lys Lys Leu Gln Pro Ile 
        35                  40                  45              


Gln Thr Ala Ala Lys Asn Val Ile Leu Phe Leu Gly Asp Gly Met Gly 
    50                  55                  60                  


Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Met Asn Gly 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Pro Leu Ala Met Asp Gln Phe Pro Tyr Val 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala 
            100                 105                 110         


Gly Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Tyr Lys Thr 
        115                 120                 125             


Ile Gly Val Ser Ala Ala Ala Arg Tyr Asn Gln Cys Asn Thr Thr Ser 
    130                 135                 140                 


Gly Asn Glu Val Thr Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Ser Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Ala Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Leu Pro Ala Asp Ala Gln Thr Tyr Gly Cys Gln Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Val Asn Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Met 
    210                 215                 220                 


Tyr Met Phe Pro Glu Gly Thr Pro Asp Pro Glu Tyr Pro Tyr Asp Val 
225                 230                 235                 240 


Asn Gln Thr Gly Val Arg Lys Asp Lys Arg Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Gln Ala Lys His Gln Gly Ala Gln Tyr Val Trp Asn Arg Thr Glu Leu 
            260                 265                 270         


Leu Gln Ala Ala Asn Asp Pro Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Ala Asp Met Lys Tyr Asn Val Gln Gln Asp Pro Thr Lys Asp 
    290                 295                 300                 


Pro Thr Leu Glu Glu Met Thr Glu Ala Ala Leu Gln Val Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Gln Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Glu Gly Lys Ala Tyr Met Ala Leu Thr Asp Thr Val Met 
            340                 345                 350         


Phe Asp Asn Ala Ile Ala Lys Ala Asn Glu Leu Thr Ser Glu Leu Asp 
        355                 360                 365             


Thr Leu Ile Leu Ala Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Thr Leu Arg Gly Thr Ser Ile Phe Gly Leu Ala Pro Ser Lys 
385                 390                 395                 400 


Ala Ser Asp Asn Lys Ser Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Leu Gly Gly Gly Leu Arg Pro Asp Val Asn Asp Ser Ile 
            420                 425                 430         


Ser Glu Asp Pro Ser Tyr Arg Gln Gln Ala Ala Val Pro Leu Ser Ser 
        435                 440                 445             


Glu Ser His Gly Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Glu Thr Phe Val Ala His Val 
465                 470                 475                 480 


Met Ala Phe Ala Gly Cys Val Glu Pro Tyr Thr Asp Cys Asn Leu Pro 
                485                 490                 495     


Ala Pro Ser Gly Leu Ser Asp Ala Ala His Leu Ala 
            500                 505             


<210>  8
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  8

Met Gln Gly Ala Cys Val Leu Leu Leu Leu Gly Leu His Leu Gln Leu 
1               5                   10                  15      


Ser Leu Gly Leu Ile Pro Ala Glu Glu Glu Asn Pro Ala Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Gln Ala Leu Asp Val Ala Lys Lys Leu Gln Pro Ile 
        35                  40                  45              


Gln Thr Ala Ala Lys Asn Val Ile Leu Phe Leu Gly Asp Gly Met Gly 
    50                  55                  60                  


Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Met Asn Gly 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Pro Leu Ala Met Asp Gln Phe Pro Tyr Val 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala 
            100                 105                 110         


Gly Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Tyr Arg Thr 
        115                 120                 125             


Ile Gly Val Ser Ala Ala Ala Arg Tyr Asn Gln Cys Asn Thr Thr Arg 
    130                 135                 140                 


Gly Asn Glu Val Thr Ser Val Ile Asn Arg Ala Lys Lys Ala Gly Lys 
145                 150                 155                 160 


Ala Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Ala Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Leu Pro Ala Asp Ala Gln Lys Asn Gly Cys Gln Asp Ile Ala Ala Gln 
        195                 200                 205             


Leu Val Tyr Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Met 
    210                 215                 220                 


Tyr Met Phe Pro Glu Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Ala 
225                 230                 235                 240 


Ser Val Asn Gly Val Arg Lys Asp Lys Gln Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Gln Ala Lys His Gln Gly Ala Gln Tyr Val Trp Asn Arg Thr Ala Leu 
            260                 265                 270         


Leu Gln Ala Ala Asp Asp Ser Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Ala Asp Met Lys Tyr Asn Val Gln Gln Asp His Thr Lys Asp 
    290                 295                 300                 


Pro Thr Leu Ala Glu Met Thr Glu Ala Ala Leu Gln Val Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Arg Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Asp Gly Lys Ala Tyr Met Ala Leu Thr Glu Ala Ile Met 
            340                 345                 350         


Phe Asp Asn Ala Ile Ala Lys Ala Asn Glu Leu Thr Ser Glu Leu Asp 
        355                 360                 365             


Thr Leu Ile Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Thr Leu Arg Gly Thr Ser Ile Phe Gly Leu Ala Pro Gly Lys 
385                 390                 395                 400 


Ala Leu Asp Ser Lys Ser Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Ala Leu Gly Gly Gly Ser Arg Pro Asp Val Asn Gly Ser Thr 
            420                 425                 430         


Ser Glu Glu Pro Ser Tyr Arg Gln Gln Ala Ala Val Pro Leu Ala Ser 
        435                 440                 445             


Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Glu Thr Phe Val Ala His Ile 
465                 470                 475                 480 


Met Ala Phe Ala Gly Cys Val Glu Pro Tyr Thr Asp Cys Asn Leu Pro 
                485                 490                 495     


Ala Pro Ala Thr Ala Thr Ser Ile Pro Asp Gly Gly Ser Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Cys Asp 
        515                 520                 525             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    530                 535                 540                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
545                 550                 555                 560 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                565                 570                 575     


Asp Pro Gln Val Lys Phe Asn Trp Tyr Val Asp Gly Val Gln Val His 
            580                 585                 590         


Asn Ala Lys Thr Lys Pro Arg Glu Gln Gln Tyr Asn Ser Thr Tyr Arg 
        595                 600                 605             


Val Val Ser Val Leu Thr Val Leu His Gln Asn Trp Leu Asp Gly Lys 
    610                 615                 620                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
625                 630                 635                 640 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                645                 650                 655     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            660                 665                 670         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        675                 680                 685             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    690                 695                 700                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
705                 710                 715                 720 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                725                 730                 735     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            740                 745                 750         


Gly Lys 
        


<210>  9
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  9

Met Gln Trp Ala Cys Val Leu Leu Leu Leu Gly Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Leu Thr Phe Ile Pro Ala Glu Glu Glu Asp Pro Ala Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Gln Ala Leu Asp Val Ala Lys Lys Leu Gln Pro Ile 
        35                  40                  45              


Gln Thr Ala Ala Lys Asn Val Ile Leu Phe Leu Gly Asp Gly Met Gly 
    50                  55                  60                  


Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Met Asn Gly 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Pro Leu Ala Met Asp Gln Phe Pro Tyr Val 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala 
            100                 105                 110         


Gly Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Tyr Lys Thr 
        115                 120                 125             


Ile Gly Val Ser Ala Ala Ala Arg Tyr Asn Gln Cys Asn Thr Thr Ser 
    130                 135                 140                 


Gly Asn Glu Val Thr Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Ser Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Ala Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Leu Pro Ala Asp Ala Gln Thr Tyr Gly Cys Gln Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Val Asn Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Met 
    210                 215                 220                 


Tyr Met Phe Pro Glu Gly Thr Pro Asp Pro Glu Tyr Pro Tyr Asp Val 
225                 230                 235                 240 


Asn Gln Thr Gly Val Arg Lys Asp Lys Arg Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Gln Ala Lys His Gln Gly Ala Gln Tyr Val Trp Asn Arg Thr Glu Leu 
            260                 265                 270         


Leu Gln Ala Ala Asn Asp Pro Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Ala Asp Met Lys Tyr Asn Val Gln Gln Asp Pro Thr Lys Asp 
    290                 295                 300                 


Pro Thr Leu Glu Glu Met Thr Glu Ala Ala Leu Gln Val Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Gln Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Glu Gly Lys Ala Tyr Met Ala Leu Thr Asp Thr Val Met 
            340                 345                 350         


Phe Asp Asn Ala Ile Ala Lys Ala Asn Glu Leu Thr Ser Glu Leu Asp 
        355                 360                 365             


Thr Leu Ile Leu Ala Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Thr Leu Arg Gly Thr Ser Ile Phe Gly Leu Ala Pro Ser Lys 
385                 390                 395                 400 


Ala Ser Asp Asn Lys Ser Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Leu Gly Gly Gly Leu Arg Pro Asp Val Asn Asp Ser Ile 
            420                 425                 430         


Ser Glu Asp Pro Ser Tyr Arg Gln Gln Ala Ala Val Pro Leu Ser Ser 
        435                 440                 445             


Glu Ser His Gly Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Glu Thr Phe Val Ala His Val 
465                 470                 475                 480 


Met Ala Phe Ala Gly Cys Val Glu Pro Tyr Thr Asp Cys Asn Leu Pro 
                485                 490                 495     


Ala Pro Ser Gly Leu Ser Asp Gly Gly Ser Gly Gly Ser Gly Gly Gly 
            500                 505                 510         


Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Cys Asp Lys Thr His 
        515                 520                 525             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    530                 535                 540                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
545                 550                 555                 560 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Gln 
                565                 570                 575     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Gln Val His Asn Ala Lys 
            580                 585                 590         


Thr Lys Pro Arg Glu Gln Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        595                 600                 605             


Val Leu Thr Val Leu His Gln Asn Trp Leu Asp Gly Lys Glu Tyr Lys 
    610                 615                 620                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
625                 630                 635                 640 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                645                 650                 655     


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            660                 665                 670         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        675                 680                 685             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    690                 695                 700                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
705                 710                 715                 720 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                725                 730                 735     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745                 750     


<210>  10
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  10

Met Gln Trp Ala Cys Val Leu Leu Leu Leu Gly Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Leu Thr Phe Ile Pro Ala Glu Glu Glu Asp Pro Ala Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Gln Ala Leu Asp Val Ala Lys Lys Leu Gln Pro Ile 
        35                  40                  45              


Gln Thr Ala Ala Lys Asn Val Ile Leu Phe Leu Gly Asp Gly Met Gly 
    50                  55                  60                  


Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Met Asn Gly 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Pro Leu Ala Met Asp Gln Phe Pro Tyr Val 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala 
            100                 105                 110         


Gly Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Tyr Lys Thr 
        115                 120                 125             


Ile Gly Val Ser Ala Ala Ala Arg Tyr Asn Gln Cys Asn Thr Thr Ser 
    130                 135                 140                 


Gly Asn Glu Val Thr Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Ser Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Ala Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Leu Pro Ala Asp Ala Gln Thr Tyr Gly Cys Gln Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Val Asn Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Met 
    210                 215                 220                 


Tyr Met Phe Pro Glu Gly Thr Pro Asp Pro Glu Tyr Pro Tyr Asp Val 
225                 230                 235                 240 


Asn Gln Thr Gly Val Arg Lys Asp Lys Arg Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Gln Ala Lys His Gln Gly Ala Gln Tyr Val Trp Asn Arg Thr Glu Leu 
            260                 265                 270         


Leu Gln Ala Ala Asn Asp Pro Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Ala Asp Met Lys Tyr Asn Val Gln Gln Asp Pro Thr Lys Asp 
    290                 295                 300                 


Pro Thr Leu Glu Glu Met Thr Glu Ala Ala Leu Gln Val Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Gln Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Glu Gly Lys Ala Tyr Met Ala Leu Thr Asp Thr Val Met 
            340                 345                 350         


Phe Asp Asn Ala Ile Ala Lys Ala Asn Glu Leu Thr Ser Glu Leu Asp 
        355                 360                 365             


Thr Leu Ile Leu Ala Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Thr Leu Arg Gly Thr Ser Ile Phe Gly Leu Ala Pro Ser Lys 
385                 390                 395                 400 


Ala Ser Asp Asn Lys Ser Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Leu Gly Gly Gly Leu Arg Pro Asp Val Asn Asp Ser Ile 
            420                 425                 430         


Ser Glu Asp Pro Ser Tyr Arg Gln Gln Ala Ala Val Pro Leu Ser Ser 
        435                 440                 445             


Glu Ser His Gly Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Glu Thr Phe Val Ala His Val 
465                 470                 475                 480 


Met Ala Phe Ala Gly Cys Val Glu Pro Tyr Thr Asp Cys Asn Leu Glu 
                485                 490                 495     


Val Leu Phe Gln Gly Pro Ala Pro Pro Ala Gly Thr Thr Asp Ala Ala 
            500                 505                 510         


His Pro Gly Arg Ser Val Val Pro Ala Leu Leu Pro Leu Arg Ala Gly 
        515                 520                 525             


Thr Leu Leu Leu Leu Glu Thr Ala Thr Ala Pro 
    530                 535                 


<210>  11
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  11

Met Gln Trp Ala Cys Val Leu Leu Leu Leu Gly Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Leu Thr Phe Ile Pro Ala Glu Glu Glu Asp Pro Ala Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Gln Ala Leu Asp Val Ala Lys Lys Leu Gln Pro Ile 
        35                  40                  45              


Gln Thr Ala Ala Lys Asn Val Ile Leu Phe Leu Gly Asp Gly Met Gly 
    50                  55                  60                  


Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Met Asn Gly 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Pro Leu Ala Met Asp Gln Phe Pro Tyr Val 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala 
            100                 105                 110         


Gly Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Tyr Lys Thr 
        115                 120                 125             


Ile Gly Val Ser Ala Ala Ala Arg Tyr Asn Gln Cys Asn Thr Thr Ser 
    130                 135                 140                 


Gly Asn Glu Val Thr Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Ser Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Ala Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Leu Pro Ala Asp Ala Gln Thr Tyr Gly Cys Gln Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Val Asn Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Met 
    210                 215                 220                 


Tyr Met Phe Pro Glu Gly Thr Pro Asp Pro Glu Tyr Pro Tyr Asp Val 
225                 230                 235                 240 


Asn Gln Thr Gly Val Arg Lys Asp Lys Arg Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Gln Ala Lys His Gln Gly Ala Gln Tyr Val Trp Asn Arg Thr Glu Leu 
            260                 265                 270         


Leu Gln Ala Ala Asn Asp Pro Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Ala Asp Met Lys Tyr Asn Val Gln Gln Asp Pro Thr Lys Asp 
    290                 295                 300                 


Pro Thr Leu Glu Glu Met Thr Glu Ala Ala Leu Gln Val Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Gln Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Glu Gly Lys Ala Tyr Met Ala Leu Thr Asp Thr Val Met 
            340                 345                 350         


Phe Asp Asn Ala Ile Ala Lys Ala Asn Glu Leu Thr Ser Glu Leu Asp 
        355                 360                 365             


Thr Leu Ile Leu Ala Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Thr Leu Arg Gly Thr Ser Ile Phe Gly Leu Ala Pro Ser Lys 
385                 390                 395                 400 


Ala Ser Asp Asn Lys Ser Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Leu Gly Gly Gly Leu Arg Pro Asp Val Asn Asp Ser Ile 
            420                 425                 430         


Ser Glu Asp Pro Ser Tyr Arg Gln Gln Ala Ala Val Pro Leu Ser Ser 
        435                 440                 445             


Glu Ser His Gly Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Glu Thr Phe Val Ala His Val 
465                 470                 475                 480 


Met Ala Phe Ala Gly Cys Val Glu Pro Tyr Thr Asp Cys Asn Leu Ala 
                485                 490                 495     


Pro Pro Ala Gly Thr Thr Asp Ala Ala His Pro Ile Glu Gly Arg Ser 
            500                 505                 510         


Val Val Pro Ala Leu Leu Pro Leu Arg Ala Gly Thr Leu Leu Leu Leu 
        515                 520                 525             


Glu Thr Ala Thr Ala Pro 
    530                 


<210>  12
<211>  1669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  12
atgcaggggc cctgggtgct gctgctgctg ggcctgaggc tacagctctc cctgggcgtc       60

atcccaggta atgaggctcc ccaagctgtt ccacacacag ggcaccccct cagccaggct      120

gacctgatct ctactctccc cctggccagc tgaggaggag aacccggcct tctggaaccg      180

ccaggcagct gaggccctgg atgctgccaa gaagctgcag cccatccaga aggtcgccaa      240

gaacctcatc ctcttcctgg gcgatgggtt gggggtgccc acggtgacag ccaccaggat      300

cctaaagggg cagaagaatg gcaaactggg gcctgagacg cccctggcca tggaccgctt      360

cccatacctg gctctgtcca agacatacaa tgtggacaga caggtgccag acagcgcagc      420

cacagccacg gcctacctgt gcggggtcaa ggccaacttc cagaccatcg gcttgagtgc      480

agccgcccgc tttaaccagt gcaacacgac acgcggcaat gaggtcatct ccgtgatgaa      540

ccgggccaag caagcaggaa agtcagtagg agtggtgacc accacacggg tgcagcacgc      600

ctcgccagcc ggcacctacg cacacacagt gaaccgcaac tggtactcag atgctgacat      660

gcctgcctca gcccgccagg aggggtgcca ggacatcgcc actcagctca tctccaacat      720

ggacattgac gtgatccttg gcggaggccg caagtacatg tttcccatgg ggaccccaga      780

ccctgagtac ccagctgatg ccagccagaa tggaatcagg ctggacggga agaacctggt      840

gcaggaatgg ctggcaaagc accagggtgc ctggtatgtg tggaaccgca ctgagctcat      900

gcaggcgtcc ctggaccagt ctgtgaccca tctcatgggc ctctttgagc ccggagacac      960

gaaatatgag atccaccgag accccacact ggacccctcc ctgatggaga tgacagaggc     1020

tgccctgcgc ctgctgagca ggaacccccg cggcttctac ctctttgtgg agggcggccg     1080

catcgaccat ggtcatcatg agggtgtggc ttaccaggca ctcactgagg cggtcatgtt     1140

cgacgacgcc attgagaggg cgggccagct caccagcgag gaggacacgc tgaccctcgt     1200

caccgctgac cactcccatg tcttctcctt tggtggctac accttgcgag ggagctccat     1260

cttcgggttg gcccccagca aggctcagga cagcaaagcc tacacgtcca tcctgtacgg     1320

caatggcccg ggctacgtgt tcaactcagg cgtgcgacca gacgtgaatg agagcgagag     1380

cgggagcccc gattaccagc agcaggcggc ggtgcccctg tcgtccgaga cccacggagg     1440

cgaagacgtg gcggtgtttg cgcgcggccc gcaggcgcac ctggtgcatg gtgtgcagga     1500

gcagagcttc gtagcgcatg tcatggcctt cgctgcctgt ctggagccct acacggcctg     1560

cgacctggcg cctcccgcct gcaccaccga cgccgcgcac ccagttgccg cgtcgctgcc     1620

actgctggcc gggaccctgc tgctgctggg ggcgtccgct gctccctga                 1669


<210>  13
<211>  1671
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  13
atgcaggggc cctgggtgct gctgctgctg ggcctgaggc tacagctctc cctgggcgtc       60

atcccagctg aggaggagaa cccggccttc tggaaccgcc aggcagctga ggccctggat      120

gctgccaaga agctgcagcc catccagaag gtcgccaaga acctcatcct cttcctgggc      180

gatgggttgg gggtgcccac ggtgacagcc accaggatcc taaaggggca gaagaatggc      240

aaactggggc ctgagacgcc cctggccatg gaccgcttcc catacctggc tctgtccaag      300

acatacaatg tggacagaca ggtgccagac agcgcagcca cagccacggc ctacctgtgc      360

ggggtcaagg ccaacttcca gaccatcggc ttgagtgcag ccgcccgctt taaccagtgc      420

aacacgacac gcggcaatga ggtcatctcc gtgatgaacc gggccaagca agcaggaaag      480

tcagtaggag tggtgaccac cacacgggtg cagcacgcct cgccagccgg cacctacgca      540

cacacagtga accgcaactg gtactcagat gctgacatgc ctgcctcagc ccgccaggag      600

gggtgccagg acatcgccac tcagctcatc tccaacatgg acattgacgt gatccttggc      660

ggaggccgca agtacatgtt tcccatgggg accccagacc ctgagtaccc agctgatgcc      720

agccagaatg gaatcaggct ggacgggaag aacctggtgc aggaatggct ggcaaagcac      780

cagggtgcct ggtatgtgtg gaaccgcact gagctcatgc aggcgtccct ggaccagtct      840

gtgacccatc tcatgggcct ctttgagccc ggagacacga aatatgagat ccaccgagac      900

cccacactgg acccctccct gatggagatg acagaggctg ccctgcgcct gctgagcagg      960

aacccccgcg gcttctacct ctttgtggag ggcggccgca tcgaccatgg tcatcatgag     1020

ggtgtggctt accaggcact cactgaggcg gtcatgttcg acgacgccat tgagagggcg     1080

ggccagctca ccagcgagga ggacacgctg accctcgtca ccgctgacca ctcccatgtc     1140

ttctcctttg gtggctacac cttgcgaggg agctccatct tcgggttggc ccccagcaag     1200

gctcaggaca gcaaagccta cacgtccatc ctgtacggca atggcccggg ctacgtgttc     1260

aactcaggcg tgcgaccaga cgtgaatgag agcgagagcg ggagccccga ttaccagcag     1320

caggcggcgg tgcccctgtc gtccgagacc cacggaggcg aagacgtggc ggtgtttgcg     1380

cgcggcccgc aggcgcacct ggtgcatggt gtgcaggagc agagcttcgt agcgcatgtc     1440

atggccttcg ctgcctgtct ggagccctac acggcctgcg acctggcgcc tcccgcctgc     1500

accaccgacg ccgcgcaccc agttgccgcg tcgctgccac tgctggccgg gaccctgctg     1560

ctgctggggg cgtccgctgc tccctgattt actaaaacct tgaaataaaa ttgtaaaaca     1620

tcagtttgaa ggcctgactc tcagggtagt tcttttttaa ttctgggttt t              1671


<210>  14
<211>  1672
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  14
atgcagtggg cctgtgtgct gctgctgctg ggcctgtggc tacagctctc cctcaccttc       60

atcccaggta atcaggcggc tcccagcagc ccctactcac aggggcggct ctaggctgac      120

ctgaccaaca ctctcccctt gggcagctga ggaggaagac cccgccttct ggaaccgcca      180

ggcagcccag gcccttgatg tagccaagaa gttgcagccg atccagacag ctgccaagaa      240

tgtcatcctc ttcttggggg atgggatggg ggtgcctacg gtgacagcca ctcggatcct      300

aaaggggcag atgaatggta agctgggacc tgagacaccc ctggccatgg accagttccc      360

atacgtggct ctgtccaaga catacaacgt ggacagacag gtgccagaca gcgcaggcac      420

tgccactgcc tacctgtgtg gggtcaaggg caactacaaa accattggtg taagtgcagc      480

cgcccgctac aaccagtgca acacaacaag tggcaatgag gtcacgtctg tgatgaaccg      540

ggccaagaaa gcaggaaagt cagtgggagt ggtgaccacc tccagggtgc agcatgcctc      600

cccagccggt gcttatgcac acacggtgaa ccgaaactgg tactcagatg ccgacctgcc      660

tgccgatgca cagacgtatg gctgccagga catcgccaca caactggtca acaacatgga      720

tattgacgtg atcctgggtg gaggccgaat gtacatgttt cctgagggga ccccggatcc      780

tgaataccca tacgatgtca atcagactgg agtccggaag gacaagcgga atctggtgca      840

ggagtggcag gccaagcacc agggagccca gtatgtgtgg aaccgcacgg agctccttca      900

ggcagccaat gaccccagtg taacacacct catgggcctc tttgagccgg cagacatgaa      960

gtataatgtt cagcaagacc ccaccaagga cccgaccctg gaggagatga cggaggcggc     1020

cctgcaagtg ctgagcagga acccccaggg cttctacctc ttcgtggagg gaggccgcat     1080

tgaccacggt caccatgaag gcaaagctta tatggcactg actgatacag tcatgtttga     1140

caatgccatc gccaaggcta acgagctcac tagcgaactg gacacgctga tccttgccac     1200

tgcagaccac tcccatgtct tctcttttgg tggctacaca ctgcgtggga cctccatttt     1260

cggtctggcc cccagcaagg cctcagacaa caagtcctac acctccatcc tctatggcaa     1320

tggccctggc tacgtgcttg gtgggggctt aaggcccgat gttaatgaca gcataagcga     1380

ggacccctcg taccggcagc aggcggccgt gcccctgtct agtgagtccc acgggggcga     1440

ggacgtggcg gtgttcgcgc gaggcccgca ggcgcacctg gtgcacggcg tgcaggagga     1500

gaccttcgtg gcgcacgtca tggcctttgc gggctgcgtg gagccctaca ccgactgcaa     1560

tctgccggcc ccctctggcc tctccgacgc cgcgcacctg gcggccagcc cgccttcgct     1620

ggcgctgctg gccggggcga tgctgctgct gctggcgcct gccttgtact ga             1672


<210>  15
<211>  1869
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  15
atgcagtggg cctgtgtgct gctgctgctg ggcctgtggc tacagctctc cctcaccttc       60

atcccagctg aggaggaaga ccccgccttc tggaaccgcc aggcagccca ggcccttgat      120

gtagccaaga agttgcagcc gatccagaca gctgccaaga atgtcatcct cttcttgggg      180

gatgggatgg gggtgcctac ggtgacagcc actcggatcc taaaggggca gatgaatggt      240

aagctgggac ctgagacacc cctggccatg gaccagttcc catacgtggc tctgtccaag      300

acatacaacg tggacagaca ggtgccagac agcgcaggca ctgccactgc ctacctgtgt      360

ggggtcaagg gcaactacaa aaccattggt gtaagtgcag ccgcccgcta caaccagtgc      420

aacacaacaa gtggcaatga ggtcacgtct gtgatgaacc gggccaagaa agcaggaaag      480

tcagtgggag tggtgaccac ctccagggtg cagcatgcct ccccagccgg tgcttatgca      540

cacacggtga accgaaactg gtactcagat gccgacctgc ctgccgatgc acagacgtat      600

ggctgccagg acatcgccac acaactggtc aacaacatgg atattgacgt gatcctgggt      660

ggaggccgaa tgtacatgtt tcctgagggg accccggatc ctgaataccc atacgatgtc      720

aatcagactg gagtccggaa ggacaagcgg aatctggtgc aggagtggca ggccaagcac      780

cagggagccc agtatgtgtg gaaccgcacg gagctccttc aggcagccaa tgaccccagt      840

gtaacacacc tcatgggcct ctttgagccg gcagacatga agtataatgt tcagcaagac      900

cccaccaagg acccgaccct ggaggagatg acggaggcgg ccctgcaagt gctgagcagg      960

aacccccagg gcttctacct cttcgtggag ggaggccgca ttgaccacgg tcaccatgaa     1020

ggcaaagctt atatggcact gactgataca gtcatgtttg acaatgccat cgccaaggct     1080

aacgagctca ctagcgaact ggacacgctg atccttgcca ctgcagacca ctcccatgtc     1140

ttctcttttg gtggctacac actgcgtggg acctccattt tcggtctggc ccccagcaag     1200

gcctcagaca acaagtccta cacctccatc ctctatggca atggccctgg ctacgtgctt     1260

ggtgggggct taaggcccga tgttaatgac agcataagcg aggacccctc gtaccggcag     1320

caggcggccg tgcccctgtc tagtgagtcc cacgggggcg aggacgtggc ggtgttcgcg     1380

cgaggcccgc aggcgcacct ggtgcacggc gtgcaggagg agaccttcgt ggcgcacgtc     1440

atggcctttg cgggctgcgt ggagccctac accgactgca atctgccggc cccctctggc     1500

ctctccgacg ccgcgcacct ggcggccagc ccgccttcgc tggcgctgct ggccggggcg     1560

atgctgctgc tgctggcgcc tgccttgtac tgaggggacc cgggggtggg gacacaggcc     1620

ccgccctccc tgggaggcag gaagcagctc tcaaataaac tgttctaagt atgatacagg     1680

agtgatacat gtgtgaagag aagcccttag gtgggggcac agagtgtctg ggtgaggggg     1740

gtcagggtca catcaggagg ttagggaggg gttgatgaag ggctgacgtt gagcaaagac     1800

caaaggcaac tcagaaggac agtggtgcag gactgggtgt ggtcagcagg gggactggtt     1860

gggggatcc                                                             1869


<210>  16
<211>  1260
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  16
aaaaaacaag acaaagctga gatcagaaat gtcattgtga tgataggcga cggcatgggg       60

acgccttaca taagagccta ccgttccatg aaaaataacg gtgacacacc gaataacccg      120

aagttaacag aatttgaccg gaacctgaca ggcatgatga tgacgcatcc ggatgaccct      180

gactataata ttacagattc agcagcagcc ggaacagcat tagcgacagg cgttaagaca      240

tataacaatg caattggcgt cgataaaaac ggaaaaaaag tgaaatctgt acttgaagag      300

gccaaacagc aaggcaagtc aacagggctt gtcgccacgt ctgaaattaa ccacgccact      360

ccagccgcat atggcgccca caatgaatca cggaaaaaca tggaccaaat cgccaacagc      420

tatatggatg acaagataaa aggcaaacat aaaatagacg tgctgctcgg cggcggaaaa      480

tcttatttta accgcaagaa cagaaacttg acaaaggaat tcaaacaagc cggctacagc      540

tatgtgacaa ctaaacaagc attgaaaaaa aataaagatc agcaggtgct cgggcttttc      600

gcagatggag ggcttgctaa agcgctcgac cgtgacagta aaacaccgtc tctcaaagac      660

atgacggttt cagcaattga tcgcctgaac caaaataaaa aaggattttt cttgatggtc      720

gaagggagcc agattgactg ggcggcccat gacaatgata cagtaggagc catgagcgag      780

gttaaagatt ttgaacaggc ctataaagcc gcgattgaat ttgcgaaaaa agacaaacat      840

acacttgtga ttgcaactgc tgaccataca accggcggct ttaccattgg cgcaaacggg      900

gaaaagaatt ggcacgcaga accgattctc tccgctaaga aaacacctga attcatggcc      960

aaaaaaatca gtgaaggcaa gccggttaaa gatgtgctcg cccgctatgc caatctgaaa     1020

gtcacatctg aagaaatcaa aagcgttgaa gcagctgcac aggctgacaa aagcaaaggg     1080

gcctccaaag ccatcatcaa gatttttaat acccgctcca acagcggatg gacgagtacc     1140

gatcataccg gcgaagaagt accggtatac gcgtacggcc ccggaaaaga aaaattccgc     1200

ggattgatta acaatacgga ccaggcaaac atcatattta agattttaaa aactggaaaa     1260


<210>  17
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  17

Lys Lys Gln Asp Lys Ala Glu Ile Arg Asn Val Ile Val Met Ile Gly 
1               5                   10                  15      


Asp Gly Met Gly Thr Pro Tyr Ile Arg Ala Tyr Arg Ser Met Lys Asn 
            20                  25                  30          


Asn Gly Asp Thr Pro Asn Asn Pro Lys Leu Thr Glu Phe Asp Arg Asn 
        35                  40                  45              


Leu Thr Gly Met Met Met Thr His Pro Asp Asp Pro Asp Tyr Asn Ile 
    50                  55                  60                  


Thr Asp Ser Ala Ala Ala Gly Thr Ala Leu Ala Thr Gly Val Lys Thr 
65                  70                  75                  80  


Tyr Asn Asn Ala Ile Gly Val Asp Lys Asn Gly Lys Lys Val Lys Ser 
                85                  90                  95      


Val Leu Glu Glu Ala Lys Gln Gln Gly Lys Ser Thr Gly Leu Val Ala 
            100                 105                 110         


Thr Ser Glu Ile Asn His Ala Thr Pro Ala Ala Tyr Gly Ala His Asn 
        115                 120                 125             


Glu Ser Arg Lys Asn Met Asp Gln Ile Ala Asn Ser Tyr Met Asp Asp 
    130                 135                 140                 


Lys Ile Lys Gly Lys His Lys Ile Asp Val Leu Leu Gly Gly Gly Lys 
145                 150                 155                 160 


Ser Tyr Phe Asn Arg Lys Asn Arg Asn Leu Thr Lys Glu Phe Lys Gln 
                165                 170                 175     


Ala Gly Tyr Ser Tyr Val Thr Thr Lys Gln Ala Leu Lys Lys Asn Lys 
            180                 185                 190         


Asp Gln Gln Val Leu Gly Leu Phe Ala Asp Gly Gly Leu Ala Lys Ala 
        195                 200                 205             


Leu Asp Arg Asp Ser Lys Thr Pro Ser Leu Lys Asp Met Thr Val Ser 
    210                 215                 220                 


Ala Ile Asp Arg Leu Asn Gln Asn Lys Lys Gly Phe Phe Leu Met Val 
225                 230                 235                 240 


Glu Gly Ser Gln Ile Asp Trp Ala Ala His Asp Asn Asp Thr Val Gly 
                245                 250                 255     


Ala Met Ser Glu Val Lys Asp Phe Glu Gln Ala Tyr Lys Ala Ala Ile 
            260                 265                 270         


Glu Phe Ala Lys Lys Asp Lys His Thr Leu Val Ile Ala Thr Ala Asp 
        275                 280                 285             


His Thr Thr Gly Gly Phe Thr Ile Gly Ala Asn Gly Glu Lys Asn Trp 
    290                 295                 300                 


His Ala Glu Pro Ile Leu Ser Ala Lys Lys Thr Pro Glu Phe Met Ala 
305                 310                 315                 320 


Lys Lys Ile Ser Glu Gly Lys Pro Val Lys Asp Val Leu Ala Arg Tyr 
                325                 330                 335     


Ala Asn Leu Lys Val Thr Ser Glu Glu Ile Lys Ser Val Glu Ala Ala 
            340                 345                 350         


Ala Gln Ala Asp Lys Ser Lys Gly Ala Ser Lys Ala Ile Ile Lys Ile 
        355                 360                 365             


Phe Asn Thr Arg Ser Asn Ser Gly Trp Thr Ser Thr Asp His Thr Gly 
    370                 375                 380                 


Glu Glu Val Pro Val Tyr Ala Tyr Gly Pro Gly Lys Glu Lys Phe Arg 
385                 390                 395                 400 


Gly Leu Ile Asn Asn Thr Asp Gln Ala Asn Ile Ile Phe Lys Ile Leu 
                405                 410                 415     


Lys Thr Gly Lys 
            420 


<210>  18
<211>  776
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  18

Met Gln Gly Pro Trp Val Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu 
1               5                   10                  15      


Ser Leu Gly Val Ile Pro Ala Glu Glu Glu Asn Pro Ala Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Glu Ala Leu Asp Ala Ala Lys Lys Leu Gln Pro Ile 
        35                  40                  45              


Gln Lys Val Ala Lys Asn Leu Ile Leu Phe Leu Gly Asp Gly Leu Gly 
    50                  55                  60                  


Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Lys Asn Gly 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Pro Leu Ala Met Asp Arg Phe Pro Tyr Leu 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala 
            100                 105                 110         


Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Phe Gln Thr 
        115                 120                 125             


Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg 
    130                 135                 140                 


Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys Gln Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Thr Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Met Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Ile Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Phe Pro Met Gly Thr Pro Asp Pro Glu Tyr Pro Ala Asp Ala 
225                 230                 235                 240 


Ser Gln Asn Gly Ile Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Leu Ala Lys His Gln Gly Ala Trp Tyr Val Trp Asn Arg Thr Glu Leu 
            260                 265                 270         


Met Gln Ala Ser Leu Asp Gln Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Gly Asp Thr Lys Tyr Glu Ile His Arg Asp Pro Thr Leu Asp 
    290                 295                 300                 


Pro Ser Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Arg Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Glu Gly Val Ala Tyr Gln Ala Leu Thr Glu Ala Val Met 
            340                 345                 350         


Phe Asp Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp 
        355                 360                 365             


Thr Leu Thr Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Thr Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Ser Lys 
385                 390                 395                 400 


Ala Gln Asp Ser Lys Ala Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Phe Asn Ser Gly Val Arg Pro Asp Val Asn Glu Ser Glu 
            420                 425                 430         


Ser Gly Ser Pro Asp Tyr Gln Gln Gln Ala Ala Val Pro Leu Ser Ser 
        435                 440                 445             


Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Gln Ser Phe Val Ala His Val 
465                 470                 475                 480 


Met Ala Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala 
                485                 490                 495     


Pro Pro Ala Cys Thr Thr Asp Ala Ala His Pro Val Ala Ala Ser Leu 
            500                 505                 510         


Pro Leu Leu Ala Gly Thr Leu Leu Leu Leu Gly Ala Ser Ala Ala Pro 
        515                 520                 525             


Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
545                 550                 555                 560 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                565                 570                 575     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            580                 585                 590         


Val Asp Val Ser His Glu Asp Pro Gln Val Lys Phe Asn Trp Tyr Val 
        595                 600                 605             


Asp Gly Val Gln Val His Asn Ala Lys Thr Lys Pro Arg Glu Gln Gln 
    610                 615                 620                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
625                 630                 635                 640 


Asn Trp Leu Asp Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                645                 650                 655     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            660                 665                 670         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        675                 680                 685             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    690                 695                 700                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
705                 710                 715                 720 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                725                 730                 735     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            740                 745                 750         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        755                 760                 765             


Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775     


<210>  19
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  19

Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  20

Gly Gly Gly Gly Ser 
1               5   


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  21

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  22
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  22

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  23
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  23

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  24

Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210>  25
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  25

Gly Gly Gly Gly Gly Gly 
1               5       


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  26

Glu Ala Ala Ala Lys 
1               5   


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  27

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10  


<210>  28
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  28

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15  


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  29

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  30

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Ala 
    


<210>  31
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  31

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala 
            20          


<210>  32
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  32

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
            20                  25          


<210>  33
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  33

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45      


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  34

Pro Ala Pro Ala Pro 
1               5   


<210>  35
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  35

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  36
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  36

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
1               5                   10              


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  37

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  38
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  38
gccgccacca tgg                                                          13


<210>  39
<211>  4
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  39
atgc                                                                     4


<210>  40
<211>  4
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  40
atgg                                                                     4


<210>  41
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  41

Leu Ile Pro Ala Glu Glu Glu Asn Pro Ala Phe Trp Asn Arg Gln Ala 
1               5                   10                  15      


Ala Gln Ala Leu Asp Val Ala Lys Lys Leu Gln Pro Ile Gln Thr Ala 
            20                  25                  30          


Ala Lys Asn Val Ile Leu Phe Leu Gly Asp Gly Met Gly Val Pro Thr 
        35                  40                  45              


Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Met Asn Gly Lys Leu Gly 
    50                  55                  60                  


Pro Glu Thr Pro Leu Ala Met Asp Gln Phe Pro Tyr Val Ala Leu Ser 
65                  70                  75                  80  


Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala Gly Thr Ala 
                85                  90                  95      


Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Tyr Arg Thr Ile Gly Val 
            100                 105                 110         


Ser Ala Ala Ala Arg Tyr Asn Gln Cys Asn Thr Thr Arg Gly Asn Glu 
        115                 120                 125             


Val Thr Ser Val Ile Asn Arg Ala Lys Lys Ala Gly Lys Ala Val Gly 
    130                 135                 140                 


Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala Gly Ala Tyr 
145                 150                 155                 160 


Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp Leu Pro Ala 
                165                 170                 175     


Asp Ala Gln Lys Asn Gly Cys Gln Asp Ile Ala Ala Gln Leu Val Tyr 
            180                 185                 190         


Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Met Tyr Met Phe 
        195                 200                 205             


Pro Glu Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Ala Ser Val Asn 
    210                 215                 220                 


Gly Val Arg Lys Asp Lys Gln Asn Leu Val Gln Glu Trp Gln Ala Lys 
225                 230                 235                 240 


His Gln Gly Ala Gln Tyr Val Trp Asn Arg Thr Ala Leu Leu Gln Ala 
                245                 250                 255     


Ala Asp Asp Ser Ser Val Thr His Leu Met Gly Leu Phe Glu Pro Ala 
            260                 265                 270         


Asp Met Lys Tyr Asn Val Gln Gln Asp His Thr Lys Asp Pro Thr Leu 
        275                 280                 285             


Ala Glu Met Thr Glu Ala Ala Leu Gln Val Leu Ser Arg Asn Pro Arg 
    290                 295                 300                 


Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His Gly His His 
305                 310                 315                 320 


Asp Gly Lys Ala Tyr Met Ala Leu Thr Glu Ala Ile Met Phe Asp Asn 
                325                 330                 335     


Ala Ile Ala Lys Ala Asn Glu Leu Thr Ser Glu Leu Asp Thr Leu Ile 
            340                 345                 350         


Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly Gly Tyr Thr 
        355                 360                 365             


Leu Arg Gly Thr Ser Ile Phe Gly Leu Ala Pro Gly Lys Ala Leu Asp 
    370                 375                 380                 


Ser Lys Ser Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro Gly Tyr Ala 
385                 390                 395                 400 


Leu Gly Gly Gly Ser Arg Pro Asp Val Asn Gly Ser Thr Ser Glu Glu 
                405                 410                 415     


Pro Ser Tyr Arg Gln Gln Ala Ala Val Pro Leu Ala Ser Glu Thr His 
            420                 425                 430         


Gly Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln Ala His Leu 
        435                 440                 445             


Val His Gly Val Gln Glu Glu Thr Phe Val Ala His Ile Met Ala Phe 
    450                 455                 460                 


Ala Gly Cys Val Glu Pro Tyr Thr Asp Cys Asn Leu Pro Ala Pro Ala 
465                 470                 475                 480 


Thr Ala Thr Ser Ile Pro Asp 
                485         


