                         SEQUENCE LISTING

<110>  Kansas State University Research Foundation
       MA, Wenjun
       WANG, Liping
       TONG, Sixiang
 
<120>  ISOLATION AND CHARACTERIZATION OF NOVEL REASSORTANT MAMMALIAN 
       ORTHEOVIRUS FROM PIGS WITH NEUROLOGICAL SIGNS

<130>  40459-PCT (19484-109)

<150>  US 62/843,150
<151>  2019-05-03

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probes/primers

<400>  1
tggcagcgdt ggatacgtta ttc                                               23


<210>  2
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probes/primers

<400>  2
gcgaaytctt cagcrgagga gc                                                22


<210>  3
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probes/primers

<400>  3
cgtgaraaag cacagcatar agcc                                              24


<210>  4
<211>  3846
<212>  DNA
<213>  Mammalian Orthoreovirus

<400>  4
gctacacgtt ccacgacaat gtcgtccatg atactgactc agtttagacc gttcattgaa       60

agcatctcag gtattactga ccaatcgaat gacgtgtttg aagatgcagc aaaagcattc      120

tcttcgttta ctcgcagcga tgtctacaaa gcgctggatg agataccttt ctctgatgat      180

gcgatgcttc caatccctcc aactatatat actaaaccat ctcacgattc atactattat      240

attgatgctc taaaccgcgt acgtcgtaga acatatcagg gccctgatga cgtgtacgta      300

cctaattgtt ctatcgttga gttgctggag ccgcatgaga ctctgacatc ttatgggcgt      360

ttgtctgaag cgattgaaaa tcgtgccaag gatggagaca gccacgccag aattgcgaca      420

acatacggta gaatcgctga atctcaagct cgacagatta aggctccatt ggagaagttt      480

gtgttggcac tattagtgtc tgaagcgggg gggtccttat atgatccagt tctgcagaag      540

tatgatgaga ttccagatct gtcgcataat tgccctttat ggtgttttag ggaaatctgt      600

cgtcacatat ctggtccatt accagaccgg gcaccttatc tttatttatc agcaggggtt      660

ttctggttaa tgtcaccacg gatgacgtct gcgatccctc cgttactatc tgatcttgtt      720

aacttagcta ttttgcagca gactgcgggt ttggatccat cattagtgaa actgggagtg      780

cagatatgcc ttcacgcagc agctagctca agttatgcgt ggtttattct aaagactaag      840

tccatttttc ctcaaaacac gctacatagt atgtatgaat ctctagaagg ggggtattgt      900

cctaaccttg aatggttaga gcctagatcg gactataagt ttatgtacat gggagtcatg      960

ccattgtcca ctaagtatgc taggtcggca ccgtctaatg aaaagaaggc gcgagaactt     1020

ggcgaaaaat atggattgag ttcagtcgtc agtgagcttc gtaaacggac agcggcctat     1080

gttaaacatg attttgcttc ggtaaggtac attcgtgacg ctatggcatg tactagcggc     1140

atttttcttg taaggacacc cactgaaacg gtattgcaag aatatacaca aagtcctgag     1200

attaaagttc ctatccccca aaaagactgg acaggccctg taggtgaaat tagaattcta     1260

aaagacacaa ctagctccat cgcgcgctac ttgtatagaa catggtactt agcagcggca     1320

agaatggcgg ctcagccacg cacatgggat ccattgttcc aggcgattat gagatctcaa     1380

tacgtgacag ctaggggtgg gtctggcgca gcactccgcg agtctttgta tgcgatcaat     1440

gtgtcgttac ctgattttaa gggcctacca gtgaaggcag caactaagat atttcaggcg     1500

gcacaattag cgaacctgcc gttctcccac acatcagtgg ctatactagc tgacacttcg     1560

atgggattgc gaaaccaggt gcagaggcgg ccacgatcca tcatgccctt aaatgtgccc     1620

caacagcagg tttcagcgcc ccatacactg accgctgatt acatcaatta tcacatgaat     1680

ctgtcgacta cgtctggtag tgcggtcatt gagaaggtga ttcctttagg tgtatacgct     1740

tcaagccctc ctaaccaatc gattaacatt gacatatctg cgtgtgacgc gagtataact     1800

tgggacttct ttctatctgt gattatggcg gctatacacg aaggtgttgc cagtagttcc     1860

attggaaaac cgtttatggg agttcctgca tccattgtaa atgatgagtc tgtcgttgga     1920

gtgagagctg ctaggccgat atcaggaatg caaaacatgg ttcaacatct atcaaaactt     1980

tataaacgcg gattttcata cagagtgaac gattcttttt ctccaggcaa cgattttact     2040

catatgacta ccacttttcc gtcaggttcg acagccacct ctactgagca cactgccaat     2100

aatagtacga tgatggagac tttcctgaca gtatggggac cagaacatac tgacgacccc     2160

gacgtcttac gtctaatgaa gtctttaact attcaaagga attacgtgtg tcagggtgat     2220

gatggattga tgattatcga tgggaatact gctggtaagg tgaaaagtga gactattcag     2280

aagatgctgg agttaatctc aagatatggt gaggagtttg gatggaaata tgacatagcg     2340

tacgatggga ctgccgaata cctaaagcta tatttcatat ttggctgtcg aattccaaat     2400

cttagtcgtc atccaatcgt tggaaaagaa cgggcgaatt cttcagcaga ggagccctgg     2460

ccagcaattt tagaccagat tatgggtatc ttctttaatg gcgttcatga cgggttacag     2520

tggcagcggt ggatacgtta ttcatgggct ctatgctgtg ctttctcacg tcaaagaaca     2580

atgattggtg agagcgtggg ctacattcaa tatcctatgt ggtcatttgt ctactgggga     2640

ttaccactgg taaaagtgtt tgggtcagac ccatggatat tttcttggta catgccgact     2700

ggagacctgg gaatgtatag ttggattagt ctaatacgac ctctaatgac aagatggatg     2760

gtagctaatg gttacgtgac tgacagatgc tcacccgtat tcgggaatgc agattatcgc     2820

aaatgtttca atgagattaa actatatcaa ggttattata tggcacaatt gcctaggaat     2880

cccacgaaat ctggacgagc ggctcctcgg gaggtgagag agcaattcac tcaggcacta     2940

tccgattatt tgatgcaaaa tccagaactg aagtcacgtg tgctgcgtgg tcgtagtgag     3000

tgggagaagt atggagcggg gataattcac aatcctccat cgctattcga tgtaccccat     3060

aagtggtatc agggtgcaca agaggcggca accgctacga gagaagagct ggcagaaatg     3120

gatgagatat taatgcgcgc tcgaaggcac agttattcgg gtttttcaaa gttgttggag     3180

gcatacctgc tcgtgaaatg gcgaatgtgc gaggcccgtg aaccggcggt tgatttgcga     3240

ttaccattgt gtgcgggtat tgacccacta aactcagatc cttttctcaa gatggtaagc     3300

gttggaccaa tgcttcagag tacgcgaaag tactttgctc agacactatt catggcgaag     3360

acggtgtcgg gtcttgacgt taacgcgatt gacagcgcgt tgttacgact gcgaacattg     3420

ggtgctgaca agaaggcatt aacagcgcag ttattaatgg tgggacttca ggagtcagag     3480

gcggacgcac tggctgggaa gataatgttg caagatgtga gtactgtgca attagccaga     3540

gtggtcaatt tagctgtgcc agacacctgg atgtcgttgg attttgactc catgttcaaa     3600

caccatgtca aattacttcc caaagatgga cgccatctaa acactgacat tccccctcgc     3660

atgggatggt tacgagctat tttacgattc ttaggtgctg gaatggtaat gactgcaact     3720

ggagttgctg ttgacatata tctggaggat atacacggtg gtggtcgatc acttggacag     3780

agattcatga cttggatgcg gcaggaagga cggtcggcgt gagtctacca tgggtcgtgg     3840

tgcgtc                                                                3846


<210>  5
<211>  3902
<212>  DNA
<213>  Mammalian Orthoreovirus

<400>  5
gcaatggcga acgtttgggg agtgagactt gcagactcgt tatcatcacc cactattgag       60

acaagaactc gtccttacac actacgcgat ttctgttccg acttggatgc tgtggctggc      120

aaggaaccct ggagaccatt acgtaatcag aggacgaatg acattgtcgc cgttcaattg      180

tttaggccac tgcaaggact ggtgcttgac actcagttct atggattccc tggcgttttt      240

tcagaatggg agcagtttat gaaggcgaaa ctccgtgtgt tgaaatatga ggttttgcgg      300

atctacccga tcagtaatta taatcatgag tgtgtcaacg tttttgtagc gaatgctctt      360

gtcggggcgt tcctgtccaa tcaagccttc tatgacttgt tgcctctatt agtaataaat      420

gatactatga taaatgactt acttgggaca ggtgccgccc tttctcaatt tttccaatct      480

catggtgagg tcttagaagt tgccgcagga aggaagtacc tgcaaatgaa gaactactcg      540

aacgatgacg atgatccacc tttgttcgcc aaagatctgt cggattatgc gaaggcgttt      600

tacagtgaca catttgagac tctagaccga tttttctgga cacatgactc gtctgcgggc      660

gttctagtgc attatgataa gcccactaac gggaatcatt acatcttggg tactttaaca      720

cagatggtta gtgctcctcc gcatattatt aacgctactg atgcgttatt gctcgaatcg      780

tgcttagagc aatttgcggc gaatgtgaga gccaggccag cgcagcctgt tacgagattg      840

gatcaatgtt atcatttacg gtggggtgct caatatgttg gtgaggactc attgacgtac      900

cgtttggggg tgctctcgct gctggctacc aacggatatc aactagctag accgatccct      960

aagcaattga cgaatcggtg gctctctagt tttgtcagtc aggtaatggc ggatggtgta     1020

aatgagacgc cattatggcc tcaagagaga tatgttcaaa tagcttacga ttcaccatct     1080

gtagtcgatg gagctacgca ctatggctat gtcagactaa atcagttacg gttgggcatg     1140

agggtgtccg ctcttcagtc gttgagtgat actccagctc cgatacagtg gttgccgcag     1200

tatactattg aacaggcagc tattgacgaa ggcgatctaa tggtttctcg cttgactcaa     1260

ctaccattac gtcctgacta tggtagcata tgggttggtg atgctctatc gtattatgtt     1320

gattacaatc gtagccatag agtcgtgcta tcatccgagt tgccacagct accagataca     1380

tactttgacg gagacgagca atacggtcgt agcttgttct ctctagctcg aaaaattggt     1440

gatcgatctc tcatcaaaga tacggcagtg cttaagcatg cgtatcaggc catcgatcca     1500

aacactggaa gggaatacct tcgcgcaggg cagtccgttg catacttcgg ggcatcagct     1560

ggtcattcgg gagcggatca acctctggta attgagccat ggacgcaggg taagattagt     1620

ggtgtgcctc cgccctcttc agttaggcag ttcgggtatg atgttgctaa aggtgcgatc     1680

gtagacttag caagaccgtt tccgtcgggc gactaccaat ttgtatattc tgacgtcgat     1740

caggtcgttg atggccacga tgatctcagc atatcctcag gactggtgga gagtctatta     1800

gactcatgca tgcatgccac atccccaggt gggtcattcg tgatgaagat taacttcccg     1860

acacgtactg tctggcacta tatagrgcag aagattctcc caaatattac ctcgtacatg     1920

ttgattaaac catttgtgac taacaatgta gaattattct ttgtggcttt cggtgtgcat     1980

caacaatcag cgttaacatg gacgtctggg gtgtatttct tcctggtcga tcatttctat     2040

cgatacgaga cactgtctac gatttcacgt cagttgccat cattcggata cgttgatgat     2100

gggtcgtccg tgacaggcat tgaaatgatc agtcttgaaa atccaggctt ttcaaatatg     2160

acccaagctg cacgtgttgg aatatccggg ttgtgtgcga atgttggtaa tgcgcgtaaa     2220

ttaatatcta tccatgaatc tcacggggca cgcgtgctca ccatcacatc aagaagatct     2280

ccagcttcgg ccaggcggaa ggctcgctta cgctatttgc cacttgtaga cccacgatct     2340

ttggaagtgc aggcccgtac gatactacca tctaacccag tattgtttga taacgtgaac     2400

ggagcatcgc ctcatgtatg tttgacgatg atgtataact ttgaggtgtc tagtgcggta     2460

tatgatggtg atgtggtact tgaccttggt accggtcctg aagcgaagat tctggagctg     2520

attcctccaa catccccggt aacatgcgta gacattaggc caactgcaca gccaagtggc     2580

tgttggaacg tacgtacgac ttttctggag cttgattact taagtgacgg ttggataacg     2640

ggtgtacgtg gcgacatcgt cacttgtatg ctgtctctgg gtgctgctgc tgctggaaaa     2700

tccatgacgt tcgacgcggc atttcaacag ctagtgaaag ttcttactaa aagcacagct     2760

aacgtgttgt tgattcaagt caattgccca acagatgtga tccgaacaat taagggatat     2820

ttggagatcg atcaaactaa taagcgatac cgatttccca agtttggccg cgatgaaccg     2880

tattctgaca tggattcctt agagcgcata tgtcggactg catggccaaa ttgttctatc     2940

acgtgggtgc ccttgcccta tgacttgcgt tggactaagc ttgctttact tgagtcgacc     3000

acattgagca gtgcgtcggt gagaattgct gaattgatgt acaagtacat gcccgtgatg     3060

agaatagata ttcatgggtt acctatggaa aagcaaggca gtttcatagt gggtcagaac     3120

tgctctttga ctataccggg cttcaacgca caggacgtat tcaattgtta tttcaactcc     3180

gcgcttgcct tctctactga ggatgttagt tctgcaatga taccgcaggt ggcggctcag     3240

tttaatgcta acaaaggaga gtggtcattg gacatggtgt tctcagacgc tggtatctac     3300

acgatgcagg cattggtcgg ttccaacgca agtcctgtgt ctctgggttc gtttgtagtg     3360

gactctccgg atgtggacat aacagatgca tggcctgctc agctggactt caccatagct     3420

ggcactgacg tcaacattac ggttaatcct tattaccgct tgatggcctt tgtgaaaatt     3480

gatggacaat ggcagattgc gaatcctgat aagttccaat tcttctcatc aagtacaggg     3540

acgttggtga tgaatgtgaa gttagatata gctgataggt acttattata ctacattcgt     3600

gacgtgcaat ctagagaggt ggggttttac atacagcacc cgttgcggtt attaaatacc     3660

attacgctgc ctacaaatga ggacttattc ttgagcgctc cggacatgcg cgagtgggca     3720

gtaaaggaga gtggtaatac catatgcata ctcaacagtc aaggttttgt gccgcctcag     3780

gattgggata ttcttaccga taccattagc tggtctcctt cgcttccaac ttacgtggta     3840

cctccgggtg attataccct gacacctctg taactcatta cccctcgtga gcgtgcctaa     3900

tt                                                                    3902


<210>  6
<211>  3864
<212>  DNA
<213>  Mammalian Orthoreovirus

<400>  6
gctaatcgtc aggatgaagc ggattccaag gaagacaaag ggcaaatcca gcggaaaggg       60

caatgactca actgatagag cggacgatgg ctcgagccaa ttacgagaca agcaaaacaa      120

taagaccggc cccgccacta cagagcctgg aatgtccaac cgagagcaat acaaagctcg      180

accaagtatt gcatctgtgc agagggccac tgagagtgca gagctgccca ttaagaataa      240

cgacgaggga acgccagata agaaaggaaa cactaaggga gactcaatta gtgagcacag      300

tgaggctaaa gacgaagcgg atgaagcgac gaagaagcag gcaaaagata cagataaagg      360

taaggcgcaa gtcacatatt cagacactgg tattaacaat gctaatgaac tgtcaaggtc      420

tgggaatgtg gataatgagg gtggaagtaa tcagaagccg atgtccacca ggatagctga      480

agcaacgtct gctatagtgt cgaaacatcc tgcgcgtgtt gggttaccac ctaccgccag      540

cagtggtcat ggatatcagt gtcatgtctg ttctgcagtc ctgtttagtc ctttagacct      600

agacgctcac gtcgcctcac atggtttgca tggtaatatg acattgacat cgagtgagat      660

tcagcgacat atcactgagt ttatcagttc atggcaaaat catcctattg ttcaagtttc      720

ggctgacgtc gaaaataaga agactgctca attgctgcac gctgacactc ctcgacttgt      780

cacttgggat gccggtttgt gtacttcgtt caaaatcgtt ccgattgtac cagctcaggt      840

gccgcaggat gtgctagcct atacgttctt tacctcatca tatgctattc aatcaccgtt      900

tccagaggcg gcagtgtcta ggattgtggt gcatacaaga tgggcatcta atgttgactt      960

tgaccgagat tcgtctgtcg tcatggcacc acccacagaa aacaatatcc atttgtttaa     1020

acagttgctg aatactgaca ccctgtctgt gaggggggct aacccgctaa tgtttagagc     1080

gaacgtatta catatgttgc tggagttcgt attggataac ttgtacctga acagacatac     1140

gggattctct caagaccaca cgccatttac tgagggcgct aatctgcgtt cacttcctgg     1200

ccccgacgct gagaaatggt attcgattat gtatccaacg cgtatgggaa caccgaatgt     1260

atcgaaaata tgtaacttcg tcgcctcttg tgtgcgaaat cgagtcggga ggtttgatcg     1320

ggcgcagatg atgaacggag ccatgtcaga gtgggtggat gtcttcgaga cttcagacgc     1380

acttaccgtc tccattcgag gccgatggat ggctagacta gctcgcatga acataaatcc     1440

aacagagatc gaatgggcgt tgactgaatg tgcacaggga tatgtgactg tcacaagtcc     1500

ttacgctcct agtgtaaata gattgatgcc atatcgtgtc tccaacactg agcggcagat     1560

atcacagata atcaggatca tgaacattgg caataatgcg acggtgatac aacccgttct     1620

gcaagatatt tcggtacttc ttcaacgcat atcaccactt cagatagatc caaccattat     1680

ttccaacact atgtcaacag tctcggagtc tactactcag acactcagcc ccgcgtcctc     1740

aattttgggt aaactacgac cgagtaactc agatttctct agttttagag ttgcgttggc     1800

tggatggctt tataatggag ttgtgacgac ggtgattgat gatagttcat atccaaagga     1860

cggtggcagc gtgacctcac ttgaaaatct gtgggatttc ttcatccttg cgcttgccct     1920

accactgaca actgacccat gtgcacctgt gaaggcgttc atgactttag ccaatatgat     1980

ggtcggcttc gagacaatcc ctatggataa tcagatctac actcaatcga gacgcgcgag     2040

tgctttctca acgcctcaca cgtggccacg atgcttcatg aacatccagt taatttctcc     2100

catcgatgct ccaatcttac gacagtgggc tgaaatcatt catagatact ggcctaaccc     2160

ttcacagatt cgttatggtg cgccgaacgt ttttggctcg gcaaatctgt tcactccacc     2220

tgaggtgctg ttattgccaa tcgatcatca accagctaat gtgacgacgc caacgttgga     2280

cttcaccaac gagttgacca attggcgcgc tcgtgtttgt gagcttatga agaatcttgt     2340

tgataatcaa agatatcaac ctggatggac gcaaagtcta gtctcgtcaa tgcgtggaac     2400

actggacaaa ttgaaattga tcaaatcgat gacaccaatg tatctgcaac agctagctcc     2460

ggtagagtta gcagtgatag ctcccatgtt gcctttccca cctttccagg tgccctacgt     2520

ccgcctcgat cgtgatagaa ttccaacaat ggtcggagtg acacgacagt cacgggacac     2580

tatctctcag ccagcgctat cactgtcgac aaccaatacc actgtcggtg tgcctctagc     2640

tctagacgca agggctatta ccgtcgcgct gttgtcaggg aaatatccgc cggatctagt     2700

gacaaatgta tggtacgctg atgccattta tccaatgtat gcggatactg aggtgttctc     2760

caatcttcag agggatatga ttacctgcga agccgtgcag acactagtga ctctagtggc     2820

gcagatatca gagacccagt atcctgtgga taggtatctt gattggatcc catcactgag     2880

agcatcggcg gcgacggcgg cgacatttgc tgagtgggtt aatacttcaa tgaagacagc     2940

gtttgatttg tctgacatgc tattagagcc tctcctaagc ggggacccga ggatgactca     3000

actagcgatt cagtatcagc aatacaatgg cagaacgttt aatgtcgtac ctgaaatgcc     3060

aggttcagtc attgctgact gcgttcaact gacagcagaa gtcttcaatc acgaatataa     3120

cctgtttggg attgcgaggg gtgatatcat cattggccgt gtccagtcga cacatttgtg     3180

gtcaccgctg gctcctccac ctgacctggt gtttgatcgt gatactcctg gcgttcacat     3240

cttcggacga gattgccgta tatcgtttgg aatgaatggc gccgcgccaa tgattagaga     3300

tgagactggc atgatggtgc ctttcgaagg aaattggatt ttcccactgg cgctttggca     3360

aatgaataca cgatatttta atcaacagtt tgacgcgtgg attaagacag gagagttgcg     3420

aatccgtatt gagatgggcg cgtatccata tatgctgcat tactatgatc cgcgtcagta     3480

tgctaatgca tggaatctga catcagcctg gcttgaagaa attacaccga cgagcattcc     3540

atccgtgcct ttcatggtgc caatttcaag tgatcatgac atttcctctg ctccagctgt     3600

ccaatatatc atttcgactg aatacaatga ccggtcctta ttctgcacta attcatcatc     3660

tccccaaact atcgctggac cagacaaaca cattccagtt gagagatata acattctgac     3720

caaccctgat gctccaccca cgcagataca actgcccgaa gttattgatt tgtacaacgt     3780

cgttacacgc tatgcgtatg agactccacc tattaccgct gttgttatgg gtgttccttg     3840

atcctcatcc tcccaacggg tgct                                            3864


<210>  7
<211>  2301
<212>  DNA
<213>  Mammalian Orthoreovirus

<400>  7
gctattcgcg gtcatggctt acatcgcagt tcctgcggtg gtgggttcac gtgcaagtga       60

ggctattgga ttgctagaat cgtttggagt agacgctggg gctgatacga atgatgtttc      120

atatcaagat catgactatg ttttggatca gttacagtat atgttagatg gatatgaggc      180

tggtgacgtc atcgatgcac tcgtccacaa gaattggttg cactattctg tctattgctt      240

gttacctccc aaaagtcaac tactagagta ttggaaaagc aatccttcag cgataccgga      300

caacgttgat cgtcgacttc gtaaacggtt aatgctaaag aaagatctca gaaaagatga      360

tgaatacaat caattggcgc gtgctttcaa gatatcggat gtctacgcac ccctcatttc      420

atctacgacg tcaccgatga caatgatcca gaacttgaat cagggcgaga tcgtgtacac      480

cacgacggac agggtaattg gggctagaat cttgttatat gctcctagaa agtactatgc      540

gtcaactcta tcatttacta tgactaagtg catcattccg tttggcaaag aggtgggccg      600

ggctcctcac tctagattta atgttggcac attcccatca attgccaccc cgaagtgttt      660

tgtcatgagt gggattgatg ttgagtccat accaaatgaa ttcatcaagt tgttttacca      720

acgtgtcaag agtgttcacg ctaatatact aaatgacata tcacctcaga tcctttctga      780

catgataaac aggaagcgtt tgcgcgttca tactccgtca gatcgccgag ccgcgcagtt      840

gatgcatttg ccctaccatg ttaagcgagg ggcgtctcat gtcgacgttt ataaggtgga      900

tgttgtggac gtattgtttg aggtagtgga tgtggccgat gggttgcgca acgtatctag      960

gaaactaact atgcacactg ttccggtatg tattctcgaa atgttgggta ttgagattgc     1020

agactattgc gttcgtcgag aggatggaat gttcatagat tggtttttgc ttttgaccat     1080

gctatctgat ggcttaactg atagaaggac gcgttgtcaa tacttgatta atccgtcaag     1140

cgtgcctcct gatgtgatac ttaacatctc tattactgga tttatcaata ggcatacgat     1200

tgacgtcatg cctgacacat acgacttcgt taaacccatt ggcgccgtgc tgcctaaggg     1260

atcatttaaa tcaacaatta tgagagttct tgactcaata tcaatattag gagtccagat     1320

catgccacgc gcgcatgtag tcgattcgga tgaggtgggt gagcaaatgg agcctacgtt     1380

tgagcatgcg gtcatggaga tatacaaagg gattgctggc gttgattcgc tggatgacct     1440

catcaagtgg gtgctgaact cggatctcat tccgcatgat gacaggcttg gccacttatt     1500

tcaagcgttt ctgcctctcg caaaagactt gttagctcca atggctagaa agttttatga     1560

taactcaatg agtgagggta gattgctgac attcgctcat gctgacagtg agttactgaa     1620

cgcaaactac tttggtcatt tattgcgact aaaaatacca tatattacgg aggttaacct     1680

aatgattcgc aagaatcgtg aaggtggaga gctatttcag cttgtgttat cacatctata     1740

taaaatgtat gctactagcg cgcagcctaa atggtttgga tcattattgc gactgttaat     1800

atgcccctgg ttgcacatgg agaaattgat aggagaagca gacccagcat ctacgtcggc     1860

tgagattgga tggtatatcc ctcgtgaaca gctgatgcaa gatggatggt gcggatgtga     1920

agatggattc attccctatg ttcgcatacg tgcgccaaag ctggttatag aggagttagc     1980

ggaaaagaac tggggccaat atcatgcgca agttattatc actgatcagc tcgtcgtagg     2040

cgaaccgcgt agggtatctg ccaaggctgt gatcaaaggc aaccacttac cagttaagtt     2100

agtctcacga tttgcatgtt tcacattgac gacgaagtat gagatgaggc tttcatgcgg     2160

ccatagcact ggacgggggg ctgcatacaa tgcgagacta gctttccgat ctgacttggc     2220

gtgatccgtg acatgcgtag tgtgacacct gcccctaggt caatgggggt aaggggcggg     2280

ctaggactac gtacgcgctt c                                               2301


<210>  8
<211>  2203
<212>  DNA
<213>  Mammalian Orthoreovirus

<400>  8
gctaatctgc tgaccgttac tctgcaaaca tggggaacgc ttcatccatt gttcagacaa       60

tcaatgtcac aggagatggc aatgtcttca agccgtcagc tgaaacgtct tcaacggctg      120

taccctcatt gagtctttca cctgggatgc tcaatcctgg cggtgtacca tggatcgcca      180

tcggggacga aacgtcggtg acttcgccgg gtgccttgcg tcggatgaca tctagagaca      240

taccagaaac agctattatc aacactgata attcatctgg ggctgtgccg agcgagtccg      300

ctttagtgcc atacaatgat gagccgctgg tagttgtcac tgagcatgca atcgctaact      360

ttactaaagc tgagatggcc ttagaattca acagagagtt tttagacaaa ctccgggtgt      420

tatccgtatc accgaagtat tccgatctgt tgacgtatgt cgattgttac gttggagtct      480

ccgcgcgtca ggcactcaat aacttccaga aacaggtgcc tgtgataacc ccaacacgtc      540

agacaatgta tgtggattcc atccaagcgg cattgaaagc gttagagaaa tgggaaattg      600

atttacgagt cgcgcagaca ttactaccaa caaacgtgcc gattggtgag gtctcatgtc      660

ccatgcagtc agtggttaag ttgctagatg atcagctacc agatgacagt ttgatcagaa      720

ggtatccgcg agaggcggcg gtagcactgg ctaaaagaaa tggagggata caatggatgg      780

atgtttcaga gggcactgtc atgaacgagg ctgttaacgc ggtagccgct agcgcactag      840

ctccttctgc atcctcgcca ccacttgaag aaaagtcaaa gctgacagaa caggccatgg      900

atttagttac agccgcagag ccagaaataa ttgcatcctt ggttcctgta ccggctccgg      960

tctttgccat ccctccaaag ccagctgatt ataacgtgag aactttgaaa attgatgagg     1020

caacgtggct gagaatgatt ccgaagacga tgaccactcc attccaaatt caagtcacgg     1080

ataatactag caccaggtgg cacatgaatt taaggggtgg aacacgggtt gtcaatctag     1140

accagattgc cccaatgcgg tttgtgcttg atttgggggg taagagttat aaagagacga     1200

gttggaatcc taacgggaag agagttggct tcattgtttt ccagtccaaa atacctttcg     1260

agctgtggac ggctgcatcg caaatagggc aagcaacagt tgttaactac gttcagctgt     1320

atgccgaaga tagttcattt acagatcagt ccatcattgc tactacttca ttggcgtata     1380

attacgaacc agagcagttg aacaaaacgg atcctgaaat gaattactac ttgcttgcca     1440

cattcattga ttcagcagaa atcaatcctt ctaatatgac tcagccggat gtgtgggatg     1500

ctttgctaac catgtcacca ttgtctgctg gtgaagtgac tgtgaaaggg gccgtagtta     1560

gtgaggtaac accagcggat ctggtcggaa gttacacacc ggaatcactt aacgcctcat     1620

tacctaatga tgccgcgcgc tgcatgattg acagggcttc aaaaatcgcg gaagctatta     1680

agatcgatga tgatgctggt ccagatgagt attctcctaa ttctgtgccg atccaaggac     1740

agttggcgat atctcagctt gaaaccggct atggtgttag gatctttaac ccgaaaggta     1800

ttctgtccaa gatagcgtcg cgcgctatgc aagcattcat tggagaccca agtactatca     1860

ttactcaggc tgctcctgtg ctttctgaca agaacaactg gatagcgctg gcgcaagggg     1920

tgaagacgag cttgcgtaca aagagccttt ccgcgggagt taagacggcc gttagcaagt     1980

tgagttcatc agaatctatt caatcttgga ctcaagggtt tctggacaaa gtctctactc     2040

atttcccagc gccaaggtct gattgccctc agtctggaga cagtgatggt gggtctgcta     2100

gacggctgaa gcgggactca tacgcaggag tggttaagcg tgggtatacg cgctagacca     2160

ctcaccctgg tgacgcgggg gtaagggacg caggaaaatc atc                       2203


<210>  9
<211>  2241
<212>  DNA
<213>  Mammalian Orthoreovirus

<400>  9
gctaaagtga ccgtggtcat ggcttcgttc aagggatttt ccgccaacac tgttccagtt       60

tctaaggcca aacgtgacat atcagccctt gctgctactc ctggatttca ttcacaatcc      120

ttcactccgt ctgtggatat gtctcaatcg cgtgagttcc ttacaaaagc gatcgagcaa      180

gggtctatgt ctatacctta ccagcatgtg aatgtaccga aagttgatcg taaagttgtt      240

agcttggtgg tgcgaccttt ttcttcaggt gctttctcta tctctggagt catttcgcca      300

gctcatgcct atctactaga ttgtctacct cagcttgaac aggcgatggc ttttgttgct      360

tcacccgaat cttttcaggc ttcagatgtt gcaaagcgtt ttgctataaa gccaggtatg      420

agcctccagg atgccatcac tgcgtttatt aatttcgtgt ctgcgatgtt gaaaatgacg      480

gtaactcgtc agaattttga tgttattgtg gctgagatcg agaggcttgc ttcaaccagc      540

gtgtctgcca ggactgaaga agcgaaagtc gctgatgagg agctgatgtt attcgggcta      600

gatcacagag ggccacagca gttggatatt tctgatgcta aggggataat gaaggctgtt      660

gacattcaga caactcatga tgtccatttg gcacccggcg ttggtaatat tgaccctgaa      720

atttataacg aagggcggtt catgtttatg cagcacaagc cacttgcagc ggatcaatcg      780

tattttacct tggagactgc ggattatttc aagatttatc caacatatga tgagcatgat      840

ggtaggatgg ctgaccaaaa gcagtcagga ttgatactat gtactaaaga tgaagtgttg      900

gctgagcaaa ctatatttaa actggacact cctgacgata aaactgttca tctgctagat      960

cgtgatgacg atcacgttgt tgccaggttt accaaagtat ttatagagga tgtggctccc     1020

gggcatcata ctgctcagcg atcgggacaa cgctctgtgc ttgatgattt atatgcgaat     1080

acgcaggtga tttccattac ctccgctgct ctgaagtggg tggtcaaaca cggcgtgtct     1140

gatggaattg tgaacagaaa gaatgtcaag gtgtgtgttg gttttgaccc cttgtacact     1200

ctgtctacgc ataacggaat atctctgtgt gccctgttaa tggatgagaa gctttcggtg     1260

ctgaacagtg cgtgtcgtat gacgttacgc tctctcatga agactagacg tgatgctgat     1320

gcgcacagag cttttcaacg agttctttct caaggataca catcgctaat gtgctattat     1380

cacccttcac ggaagctggc atatggtgag gtgctttttc cagaacgatc caatgacgtg     1440

gtcgatggga tcaagctaca gttggacgca tctagacatt gtcatgaatg tcctgtgttg     1500

cagcagaaag tggttgaatt ggaaaaacag atcgtcatgc aaaagtcgat tcagtcagat     1560

actgctccaa tagcgctgca accactgttg tctcagttgc gtgagctgtc cagtgaagtt     1620

actaggttac agatggagtt gagtagggct caatccctga atgctcagct agaggcggat     1680

gtcaaatcag ctcaatcatg cagcctggat atgtacctga gataccacac ttgcattaat     1740

ggtcatgcta aagaggatga attgcttgat gctgtgcgtg tcgcgccgga tgtgaggagg     1800

cagattatgg acaggaggag tgaggtgaga aaggggtggt gcgaacgtat ttctaaggaa     1860

gcgtctgccg aatgtcaaac tgttattgat gaactgactc tgatgaatgg aaagcaggcc     1920

caagagataa tagagttacg tgattcggct gagaattatg agaaacagat tgcggagctg     1980

gtgagtacca tcacccaaaa ccagataact tatcagcaag agttgcaagc cttagtggcg     2040

aagaacgtgg aattggacac attgaatcaa cgtcaggcta ggtcgttgcg gattactcca     2100

tctcttctat cagttactcc taccgactca gttgatggcg ccgctgacct aatcgatttc     2160

tctgttccaa ctgatgagct gtaaatgatc cgtgatgcag tgttgtccta atcccttaag     2220

ccttcccgac cccaactcat c                                               2241


<210>  10
<211>  1456
<212>  DNA
<213>  Mammalian Orthoreovirus

<400>  10
gctattcgcg cctatggatg cgtctctcat ttcagagata cggagaattg tacttcaact       60

gacgcagtcg aacaatgggt cgatcaacaa ggaactcaaa gaaatcaaag aacaagtcga      120

gatcaacgct actgatatca ggaataccaa tcttaagctc gatgggatca gaggacaagt      180

tactagcatc agtgatagca tcgcagccat tgaacgtaga ttgggtgaag tggatggtag      240

atttgtggtt atcgcgaatc agattacgca actatctaac tcagttggcc agaacactca      300

agacatatcc gccttgggtg acagactcaa tgttgttgaa ccaagaattg atgacttgga      360

tacattcgca tctaatctcg ttggacgaac atccactttg gaggcagatg ttagaggaat      420

ccgtactgaa ctgtccgcat taacgacaag agtaactacg gaagtagcga ggctagatgc      480

tctgattagc gccggtcaat catccttgac gagtctatca tcaagattgg atgcggttga      540

ggctgcgatg attaccacgg ctggccgagg cttaaggaag gatggaaata cgttgaacat      600

aattgtaggt gatgggatgt ggttcgataa ctccaatcag ctgcagttag acttatcgaa      660

tcaagccaaa ggagttggtt tcgagggtgg tggtgtggtg gcgaagattg acacgaatta      720

tttttcatat aacagtaatg gtgaaatcac acttgtgggc cagatcaatg gtttacctgc      780

cagagtgtct acattggaat ctttaaagat tgacactgtt ttgcctccct tgaccgtgtc      840

tgaagcggat ggtgccagga atctgggctt gggttatgaa acagatgact tcactgttac      900

aaattccatg ttgtctctac gttctaggct aactttgccg acataccgtt atcccttgga      960

gttagatgct tctattaacc gtgtccagat agctgaacgt tttggaatgc gcgtagggag     1020

ctggactgga caattacaat atcaacatcc gcaattgaat tggcaggcaa atgtgaccat     1080

taatctgatg aaggtggatg attggctggt gctcagtttc acgcaaatga cgacaagtgg     1140

cattatggcg gatgggaaat ttacaattaa tttttccgct ggattatctt cggggtggca     1200

gacgggagag acacaacctt cgtcaataac agatccatta tctacaacat ttgctgctgt     1260

acaatatctc aaagccaatg ggactcgtgt ggatgcattc aggattatgg gcgtatcaga     1320

gtgggttgac ggagagctag agataaagaa ttatgggggc acgtatacag gacatacgca     1380

ggtatattgg gctccatgga cgataatgta tccttgtaat gtgagataaa tctagcgcgt     1440

tccctcggca caaggg                                                     1456


<210>  11
<211>  1330
<212>  DNA
<213>  Mammalian Orthoreovirus

<400>  11
gctattcgct ggtcagttat ggctcgcgct gcgttcctat tcaagactgt tggattcggt       60

ggcctgcaaa atgtgccaat taatgatgag ttgtcgtcac atctgcttcg agccggtaat      120

tcgccatggc agctgactca gttcttagat tggataagtc ttggaagagg attagctaca      180

tcagctcttg ttccaaccgc tggttcaaga tactatcaga tgagctgttt actgagtggc      240

actctccaaa ttccgtttcg tcctaatcat cgatggggag atgctaggtt tctgcgtcta      300

gtgtggtcag ctcctacgct tgacgggttg gttgttgccc caccacaggt cttagctcag      360

ccggcgttac aggcgcaggc ggatcgagtg tatgattgtg atgattaccc attcttggca      420

cgtgacccgc gattcaaaca tcgagtgtat cagcaattga gtgccgtgac tctgctcaac      480

ctgacgggat ttgggccaat ttcctatgtt cgagtagacg aagccatgtg gagtggagat      540

gtgaaccagc ttctcatgaa ctacttcggg cacacatttg ccgaaattgc atatacatta      600

tgtcaggctt cagccaacag accttgggag cacgatggta cgtacgcgag gatgactcaa      660

atcatactgt ctttgttctg gttatcgtat gtcggtgtaa ttcatcagca gaacacttac      720

cggacgttct atttccaatg taatcggcgc ggtgacgctg ctgaagtgtg gattctttcc      780

tgctcactaa accactccgc ccaaattagg ccgggtaatc gcagtctatt cgtcatgcca      840

acaagtccag actggaatat ggacgtcaat ctaattttaa gttcgacgtt gacagggtgc      900

ttgtgttcga gctctcagtt accgctcatt gacaataact cagtgcctgc ggtttcgcgg      960

aacatccacg gctggactgg tagagctggt aaccaactgc acggtttcca agtgcgacga     1020

atggtgactg aattctgtga cagattaaga cgcgatgggg tcatgactca agctcaacag     1080

aatcaagttg aagcgctggc agatcaaact caacaattca agagggatca acttgaggcc     1140

tgggctaggg aagatgatca gtataatcag gctcatccga attctccgat gttccgtacg     1200

aagccattta cgaatgcgca atggggacga ggaaataccg gagcgactag tgccgcaatt     1260

gcagccctta tctaatcgtc ttggagtgag ggggtccccc cacacccctc acgactgacc     1320

acacattcat                                                            1330


<210>  12
<211>  1195
<212>  DNA
<213>  Mammalian Orthoreovirus

<400>  12
aaagtcacgc ctgttgtcgt cactatggct tcctcactca gagcagcgat ctctaagatc       60

aagagagatg atgttggtca acaagtttgt cccaattatg tcatgcttag gtcatcggtc      120

acaacgaaag tggtacgaaa cgttgttgag tatcaaatcc gtacgggtgg attcttttcg      180

tgcctagcta tgttaagacc gctccagtat gccaagcgtg agcgtctgct tggacaacgg      240

aatctggaac gcatatcaac tagggacatc ctccaaacac gcgacttaca ctctttatgc      300

atgccaactc ctgacgcacc aatgtccagt catcaggcag taaccatgag ggagctgatt      360

tgcagctact tcaaggtcga ccacactgat gggttgaaat atatacccat ggatgagaaa      420

tactctccat cgtcgctcgc caggctgttt actatgggta tggctggact acacattacc      480

actgagcctt cctacaaacg tgtgcccatc atgcacttgg cagcagattt agactgcatg      540

acgttagctt tgccctacat gattacactt gatggtgaca cggtggtacc tgttgcccca      600

acgctttctg cagaacagct tttggatgat ggacttaagg ggatggcgtg catggacatc      660

tcatacggat gtgaggtgga tgctaataac cgatcagctg gtgatcagag catggactct      720

tcacgatgca tcaacgaatt atattgcgag gagacggcag aagctatttg tgtactcaaa      780

acatgtcttg tgctgaactg tatgcaattc aaacttgaga tggatgattt agcacataac      840

gctgctgagc tggacaagat acagatgatg atacctttta gtgaacgcgt tttcagaatg      900

gcttctgcat ttgctaccat tgatgtccag tgtttcaggt tttgtgtaat gatgaaggat      960

aagaatttga agatagacat gcgcgaaacg atgagacttt ggactcgatc ggcgctggac     1020

gagtcagtgg ttacgtcatc tctgagtatt tcgttggatc gaggcagatg ggtggcggct     1080

gatactaatg atgctagatt gctggtgttt ccaattcgcg tgtaatgggt gagtgagccg     1140

atgtggtcgc caagacatgt gccggtgtct tggtggtggg tggcgcctaa tcatc          1195


<210>  13
<211>  1187
<212>  DNA
<213>  Mammalian Orthoreovirus

<400>  13
gctatttttg cctcttccta gacgttgtcg caatggaggt gtgcctacct aatggtcatc       60

agatcgtcga ctggatcaac aatgcattcg aaggacgggt atcgatttat agtgcacagc      120

agggatggga taagacaatt tcagctcagc cggatatgat ggtgtgtggt agcgctgtcg      180

tttgcatgca ctgtttaggt gtggttggat cattgcagcg aaagctgaaa catctgcccc      240

atcataaatg taatcagcaa ttgcgtgagc aggattatgt tgatctacaa tttgctgatc      300

gtgtaaccgc tcactggaag cgtggcatgt tatcatttgt atcccagatg catgctgtca      360

tgaacgatgt gacacctgag gagcttgaaa gagtgaggac cgacggtggg atcttggctg      420

agctcgactg gcttaaagtg gagtctggat caatgtttcg ttcgattcac tcaagctgga      480

ctgatcccct tcaggtggtc gaagatctag atactcagct agatcgctat tggacagccc      540

tgaatttgat gattgattca tcggatctag tgccgaactt catgatgcgc gatccatcgc      600

atgcttttaa tggagtgaag ctggagggtg aagcgcgaca gactcaattc ccgcgtacat      660

tcgattccgg gtcgaatctg aagtggggtg ttatggttta tgactattct gaacttgaga      720

gggattctca aaaaggacga tcctatagga aagagatcgt tacgccggcg aaagactttg      780

gccactttgg cttgtcccat tattcccgtg cgacgacacc gatccttggc aaaatgcctg      840

ccgtcttttc tggtatgctg accggaaact gtaagatgta tccgtttata aagggcactg      900

ctaagctgaa aacagtcaag aagttagttg atgctgtgaa ccacacgtgg ggttttgaga      960

agatcagata cgccttaggc cctggtggga tgacgggatg gtataatagg actatgcagc     1020

aagcgccaat tgtgctgact ccagcggcac tgactatgtt tccggatatg accagatttg     1080

gcgatctaca atatccaatc acgattggcg atccggctgt ccttgggtaa acatctccat     1140

cttctcagcg ccaggcctga ccaacctggt gtgacgtggg acaggca                   1187


<210>  14
<211>  1267
<212>  PRT
<213>  Mammalian Orthoreovirus

<400>  14

Met Ser Ser Met Ile Leu Thr Gln Phe Arg Pro Phe Ile Glu Ser Ile 
1               5                   10                  15      


Ser Gly Ile Thr Asp Gln Ser Asn Asp Val Phe Glu Asp Ala Ala Lys 
            20                  25                  30          


Ala Phe Ser Ser Phe Thr Arg Ser Asp Val Tyr Lys Ala Leu Asp Glu 
        35                  40                  45              


Ile Pro Phe Ser Asp Asp Ala Met Leu Pro Ile Pro Pro Thr Ile Tyr 
    50                  55                  60                  


Thr Lys Pro Ser His Asp Ser Tyr Tyr Tyr Ile Asp Ala Leu Asn Arg 
65                  70                  75                  80  


Val Arg Arg Arg Thr Tyr Gln Gly Pro Asp Asp Val Tyr Val Pro Asn 
                85                  90                  95      


Cys Ser Ile Val Glu Leu Leu Glu Pro His Glu Thr Leu Thr Ser Tyr 
            100                 105                 110         


Gly Arg Leu Ser Glu Ala Ile Glu Asn Arg Ala Lys Asp Gly Asp Ser 
        115                 120                 125             


His Ala Arg Ile Ala Thr Thr Tyr Gly Arg Ile Ala Glu Ser Gln Ala 
    130                 135                 140                 


Arg Gln Ile Lys Ala Pro Leu Glu Lys Phe Val Leu Ala Leu Leu Val 
145                 150                 155                 160 


Ser Glu Ala Gly Gly Ser Leu Tyr Asp Pro Val Leu Gln Lys Tyr Asp 
                165                 170                 175     


Glu Ile Pro Asp Leu Ser His Asn Cys Pro Leu Trp Cys Phe Arg Glu 
            180                 185                 190         


Ile Cys Arg His Ile Ser Gly Pro Leu Pro Asp Arg Ala Pro Tyr Leu 
        195                 200                 205             


Tyr Leu Ser Ala Gly Val Phe Trp Leu Met Ser Pro Arg Met Thr Ser 
    210                 215                 220                 


Ala Ile Pro Pro Leu Leu Ser Asp Leu Val Asn Leu Ala Ile Leu Gln 
225                 230                 235                 240 


Gln Thr Ala Gly Leu Asp Pro Ser Leu Val Lys Leu Gly Val Gln Ile 
                245                 250                 255     


Cys Leu His Ala Ala Ala Ser Ser Ser Tyr Ala Trp Phe Ile Leu Lys 
            260                 265                 270         


Thr Lys Ser Ile Phe Pro Gln Asn Thr Leu His Ser Met Tyr Glu Ser 
        275                 280                 285             


Leu Glu Gly Gly Tyr Cys Pro Asn Leu Glu Trp Leu Glu Pro Arg Ser 
    290                 295                 300                 


Asp Tyr Lys Phe Met Tyr Met Gly Val Met Pro Leu Ser Thr Lys Tyr 
305                 310                 315                 320 


Ala Arg Ser Ala Pro Ser Asn Glu Lys Lys Ala Arg Glu Leu Gly Glu 
                325                 330                 335     


Lys Tyr Gly Leu Ser Ser Val Val Ser Glu Leu Arg Lys Arg Thr Ala 
            340                 345                 350         


Ala Tyr Val Lys His Asp Phe Ala Ser Val Arg Tyr Ile Arg Asp Ala 
        355                 360                 365             


Met Ala Cys Thr Ser Gly Ile Phe Leu Val Arg Thr Pro Thr Glu Thr 
    370                 375                 380                 


Val Leu Gln Glu Tyr Thr Gln Ser Pro Glu Ile Lys Val Pro Ile Pro 
385                 390                 395                 400 


Gln Lys Asp Trp Thr Gly Pro Val Gly Glu Ile Arg Ile Leu Lys Asp 
                405                 410                 415     


Thr Thr Ser Ser Ile Ala Arg Tyr Leu Tyr Arg Thr Trp Tyr Leu Ala 
            420                 425                 430         


Ala Ala Arg Met Ala Ala Gln Pro Arg Thr Trp Asp Pro Leu Phe Gln 
        435                 440                 445             


Ala Ile Met Arg Ser Gln Tyr Val Thr Ala Arg Gly Gly Ser Gly Ala 
    450                 455                 460                 


Ala Leu Arg Glu Ser Leu Tyr Ala Ile Asn Val Ser Leu Pro Asp Phe 
465                 470                 475                 480 


Lys Gly Leu Pro Val Lys Ala Ala Thr Lys Ile Phe Gln Ala Ala Gln 
                485                 490                 495     


Leu Ala Asn Leu Pro Phe Ser His Thr Ser Val Ala Ile Leu Ala Asp 
            500                 505                 510         


Thr Ser Met Gly Leu Arg Asn Gln Val Gln Arg Arg Pro Arg Ser Ile 
        515                 520                 525             


Met Pro Leu Asn Val Pro Gln Gln Gln Val Ser Ala Pro His Thr Leu 
    530                 535                 540                 


Thr Ala Asp Tyr Ile Asn Tyr His Met Asn Leu Ser Thr Thr Ser Gly 
545                 550                 555                 560 


Ser Ala Val Ile Glu Lys Val Ile Pro Leu Gly Val Tyr Ala Ser Ser 
                565                 570                 575     


Pro Pro Asn Gln Ser Ile Asn Ile Asp Ile Ser Ala Cys Asp Ala Ser 
            580                 585                 590         


Ile Thr Trp Asp Phe Phe Leu Ser Val Ile Met Ala Ala Ile His Glu 
        595                 600                 605             


Gly Val Ala Ser Ser Ser Ile Gly Lys Pro Phe Met Gly Val Pro Ala 
    610                 615                 620                 


Ser Ile Val Asn Asp Glu Ser Val Val Gly Val Arg Ala Ala Arg Pro 
625                 630                 635                 640 


Ile Ser Gly Met Gln Asn Met Val Gln His Leu Ser Lys Leu Tyr Lys 
                645                 650                 655     


Arg Gly Phe Ser Tyr Arg Val Asn Asp Ser Phe Ser Pro Gly Asn Asp 
            660                 665                 670         


Phe Thr His Met Thr Thr Thr Phe Pro Ser Gly Ser Thr Ala Thr Ser 
        675                 680                 685             


Thr Glu His Thr Ala Asn Asn Ser Thr Met Met Glu Thr Phe Leu Thr 
    690                 695                 700                 


Val Trp Gly Pro Glu His Thr Asp Asp Pro Asp Val Leu Arg Leu Met 
705                 710                 715                 720 


Lys Ser Leu Thr Ile Gln Arg Asn Tyr Val Cys Gln Gly Asp Asp Gly 
                725                 730                 735     


Leu Met Ile Ile Asp Gly Asn Thr Ala Gly Lys Val Lys Ser Glu Thr 
            740                 745                 750         


Ile Gln Lys Met Leu Glu Leu Ile Ser Arg Tyr Gly Glu Glu Phe Gly 
        755                 760                 765             


Trp Lys Tyr Asp Ile Ala Tyr Asp Gly Thr Ala Glu Tyr Leu Lys Leu 
    770                 775                 780                 


Tyr Phe Ile Phe Gly Cys Arg Ile Pro Asn Leu Ser Arg His Pro Ile 
785                 790                 795                 800 


Val Gly Lys Glu Arg Ala Asn Ser Ser Ala Glu Glu Pro Trp Pro Ala 
                805                 810                 815     


Ile Leu Asp Gln Ile Met Gly Ile Phe Phe Asn Gly Val His Asp Gly 
            820                 825                 830         


Leu Gln Trp Gln Arg Trp Ile Arg Tyr Ser Trp Ala Leu Cys Cys Ala 
        835                 840                 845             


Phe Ser Arg Gln Arg Thr Met Ile Gly Glu Ser Val Gly Tyr Ile Gln 
    850                 855                 860                 


Tyr Pro Met Trp Ser Phe Val Tyr Trp Gly Leu Pro Leu Val Lys Val 
865                 870                 875                 880 


Phe Gly Ser Asp Pro Trp Ile Phe Ser Trp Tyr Met Pro Thr Gly Asp 
                885                 890                 895     


Leu Gly Met Tyr Ser Trp Ile Ser Leu Ile Arg Pro Leu Met Thr Arg 
            900                 905                 910         


Trp Met Val Ala Asn Gly Tyr Val Thr Asp Arg Cys Ser Pro Val Phe 
        915                 920                 925             


Gly Asn Ala Asp Tyr Arg Lys Cys Phe Asn Glu Ile Lys Leu Tyr Gln 
    930                 935                 940                 


Gly Tyr Tyr Met Ala Gln Leu Pro Arg Asn Pro Thr Lys Ser Gly Arg 
945                 950                 955                 960 


Ala Ala Pro Arg Glu Val Arg Glu Gln Phe Thr Gln Ala Leu Ser Asp 
                965                 970                 975     


Tyr Leu Met Gln Asn Pro Glu Leu Lys Ser Arg Val Leu Arg Gly Arg 
            980                 985                 990         


Ser Glu Trp Glu Lys Tyr Gly Ala  Gly Ile Ile His Asn  Pro Pro Ser 
        995                 1000                 1005             


Leu Phe  Asp Val Pro His Lys  Trp Tyr Gln Gly Ala  Gln Glu Ala 
    1010                 1015                 1020             


Ala Thr  Ala Thr Arg Glu Glu  Leu Ala Glu Met Asp  Glu Ile Leu 
    1025                 1030                 1035             


Met Arg  Ala Arg Arg His Ser  Tyr Ser Gly Phe Ser  Lys Leu Leu 
    1040                 1045                 1050             


Glu Ala  Tyr Leu Leu Val Lys  Trp Arg Met Cys Glu  Ala Arg Glu 
    1055                 1060                 1065             


Pro Ala  Val Asp Leu Arg Leu  Pro Leu Cys Ala Gly  Ile Asp Pro 
    1070                 1075                 1080             


Leu Asn  Ser Asp Pro Phe Leu  Lys Met Val Ser Val  Gly Pro Met 
    1085                 1090                 1095             


Leu Gln  Ser Thr Arg Lys Tyr  Phe Ala Gln Thr Leu  Phe Met Ala 
    1100                 1105                 1110             


Lys Thr  Val Ser Gly Leu Asp  Val Asn Ala Ile Asp  Ser Ala Leu 
    1115                 1120                 1125             


Leu Arg  Leu Arg Thr Leu Gly  Ala Asp Lys Lys Ala  Leu Thr Ala 
    1130                 1135                 1140             


Gln Leu  Leu Met Val Gly Leu  Gln Glu Ser Glu Ala  Asp Ala Leu 
    1145                 1150                 1155             


Ala Gly  Lys Ile Met Leu Gln  Asp Val Ser Thr Val  Gln Leu Ala 
    1160                 1165                 1170             


Arg Val  Val Asn Leu Ala Val  Pro Asp Thr Trp Met  Ser Leu Asp 
    1175                 1180                 1185             


Phe Asp  Ser Met Phe Lys His  His Val Lys Leu Leu  Pro Lys Asp 
    1190                 1195                 1200             


Gly Arg  His Leu Asn Thr Asp  Ile Pro Pro Arg Met  Gly Trp Leu 
    1205                 1210                 1215             


Arg Ala  Ile Leu Arg Phe Leu  Gly Ala Gly Met Val  Met Thr Ala 
    1220                 1225                 1230             


Thr Gly  Val Ala Val Asp Ile  Tyr Leu Glu Asp Ile  His Gly Gly 
    1235                 1240                 1245             


Gly Arg  Ser Leu Gly Gln Arg  Phe Met Thr Trp Met  Arg Gln Glu 
    1250                 1255                 1260             


Gly Arg  Ser Ala 
    1265         


<210>  15
<211>  1289
<212>  PRT
<213>  Mammalian Orthoreovirus


<220>
<221>  misc_feature
<222>  (628)..(628)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Met Ala Asn Val Trp Gly Val Arg Leu Ala Asp Ser Leu Ser Ser Pro 
1               5                   10                  15      


Thr Ile Glu Thr Arg Thr Arg Pro Tyr Thr Leu Arg Asp Phe Cys Ser 
            20                  25                  30          


Asp Leu Asp Ala Val Ala Gly Lys Glu Pro Trp Arg Pro Leu Arg Asn 
        35                  40                  45              


Gln Arg Thr Asn Asp Ile Val Ala Val Gln Leu Phe Arg Pro Leu Gln 
    50                  55                  60                  


Gly Leu Val Leu Asp Thr Gln Phe Tyr Gly Phe Pro Gly Val Phe Ser 
65                  70                  75                  80  


Glu Trp Glu Gln Phe Met Lys Ala Lys Leu Arg Val Leu Lys Tyr Glu 
                85                  90                  95      


Val Leu Arg Ile Tyr Pro Ile Ser Asn Tyr Asn His Glu Cys Val Asn 
            100                 105                 110         


Val Phe Val Ala Asn Ala Leu Val Gly Ala Phe Leu Ser Asn Gln Ala 
        115                 120                 125             


Phe Tyr Asp Leu Leu Pro Leu Leu Val Ile Asn Asp Thr Met Ile Asn 
    130                 135                 140                 


Asp Leu Leu Gly Thr Gly Ala Ala Leu Ser Gln Phe Phe Gln Ser His 
145                 150                 155                 160 


Gly Glu Val Leu Glu Val Ala Ala Gly Arg Lys Tyr Leu Gln Met Lys 
                165                 170                 175     


Asn Tyr Ser Asn Asp Asp Asp Asp Pro Pro Leu Phe Ala Lys Asp Leu 
            180                 185                 190         


Ser Asp Tyr Ala Lys Ala Phe Tyr Ser Asp Thr Phe Glu Thr Leu Asp 
        195                 200                 205             


Arg Phe Phe Trp Thr His Asp Ser Ser Ala Gly Val Leu Val His Tyr 
    210                 215                 220                 


Asp Lys Pro Thr Asn Gly Asn His Tyr Ile Leu Gly Thr Leu Thr Gln 
225                 230                 235                 240 


Met Val Ser Ala Pro Pro His Ile Ile Asn Ala Thr Asp Ala Leu Leu 
                245                 250                 255     


Leu Glu Ser Cys Leu Glu Gln Phe Ala Ala Asn Val Arg Ala Arg Pro 
            260                 265                 270         


Ala Gln Pro Val Thr Arg Leu Asp Gln Cys Tyr His Leu Arg Trp Gly 
        275                 280                 285             


Ala Gln Tyr Val Gly Glu Asp Ser Leu Thr Tyr Arg Leu Gly Val Leu 
    290                 295                 300                 


Ser Leu Leu Ala Thr Asn Gly Tyr Gln Leu Ala Arg Pro Ile Pro Lys 
305                 310                 315                 320 


Gln Leu Thr Asn Arg Trp Leu Ser Ser Phe Val Ser Gln Val Met Ala 
                325                 330                 335     


Asp Gly Val Asn Glu Thr Pro Leu Trp Pro Gln Glu Arg Tyr Val Gln 
            340                 345                 350         


Ile Ala Tyr Asp Ser Pro Ser Val Val Asp Gly Ala Thr His Tyr Gly 
        355                 360                 365             


Tyr Val Arg Leu Asn Gln Leu Arg Leu Gly Met Arg Val Ser Ala Leu 
    370                 375                 380                 


Gln Ser Leu Ser Asp Thr Pro Ala Pro Ile Gln Trp Leu Pro Gln Tyr 
385                 390                 395                 400 


Thr Ile Glu Gln Ala Ala Ile Asp Glu Gly Asp Leu Met Val Ser Arg 
                405                 410                 415     


Leu Thr Gln Leu Pro Leu Arg Pro Asp Tyr Gly Ser Ile Trp Val Gly 
            420                 425                 430         


Asp Ala Leu Ser Tyr Tyr Val Asp Tyr Asn Arg Ser His Arg Val Val 
        435                 440                 445             


Leu Ser Ser Glu Leu Pro Gln Leu Pro Asp Thr Tyr Phe Asp Gly Asp 
    450                 455                 460                 


Glu Gln Tyr Gly Arg Ser Leu Phe Ser Leu Ala Arg Lys Ile Gly Asp 
465                 470                 475                 480 


Arg Ser Leu Ile Lys Asp Thr Ala Val Leu Lys His Ala Tyr Gln Ala 
                485                 490                 495     


Ile Asp Pro Asn Thr Gly Arg Glu Tyr Leu Arg Ala Gly Gln Ser Val 
            500                 505                 510         


Ala Tyr Phe Gly Ala Ser Ala Gly His Ser Gly Ala Asp Gln Pro Leu 
        515                 520                 525             


Val Ile Glu Pro Trp Thr Gln Gly Lys Ile Ser Gly Val Pro Pro Pro 
    530                 535                 540                 


Ser Ser Val Arg Gln Phe Gly Tyr Asp Val Ala Lys Gly Ala Ile Val 
545                 550                 555                 560 


Asp Leu Ala Arg Pro Phe Pro Ser Gly Asp Tyr Gln Phe Val Tyr Ser 
                565                 570                 575     


Asp Val Asp Gln Val Val Asp Gly His Asp Asp Leu Ser Ile Ser Ser 
            580                 585                 590         


Gly Leu Val Glu Ser Leu Leu Asp Ser Cys Met His Ala Thr Ser Pro 
        595                 600                 605             


Gly Gly Ser Phe Val Met Lys Ile Asn Phe Pro Thr Arg Thr Val Trp 
    610                 615                 620                 


His Tyr Ile Xaa Gln Lys Ile Leu Pro Asn Ile Thr Ser Tyr Met Leu 
625                 630                 635                 640 


Ile Lys Pro Phe Val Thr Asn Asn Val Glu Leu Phe Phe Val Ala Phe 
                645                 650                 655     


Gly Val His Gln Gln Ser Ala Leu Thr Trp Thr Ser Gly Val Tyr Phe 
            660                 665                 670         


Phe Leu Val Asp His Phe Tyr Arg Tyr Glu Thr Leu Ser Thr Ile Ser 
        675                 680                 685             


Arg Gln Leu Pro Ser Phe Gly Tyr Val Asp Asp Gly Ser Ser Val Thr 
    690                 695                 700                 


Gly Ile Glu Met Ile Ser Leu Glu Asn Pro Gly Phe Ser Asn Met Thr 
705                 710                 715                 720 


Gln Ala Ala Arg Val Gly Ile Ser Gly Leu Cys Ala Asn Val Gly Asn 
                725                 730                 735     


Ala Arg Lys Leu Ile Ser Ile His Glu Ser His Gly Ala Arg Val Leu 
            740                 745                 750         


Thr Ile Thr Ser Arg Arg Ser Pro Ala Ser Ala Arg Arg Lys Ala Arg 
        755                 760                 765             


Leu Arg Tyr Leu Pro Leu Val Asp Pro Arg Ser Leu Glu Val Gln Ala 
    770                 775                 780                 


Arg Thr Ile Leu Pro Ser Asn Pro Val Leu Phe Asp Asn Val Asn Gly 
785                 790                 795                 800 


Ala Ser Pro His Val Cys Leu Thr Met Met Tyr Asn Phe Glu Val Ser 
                805                 810                 815     


Ser Ala Val Tyr Asp Gly Asp Val Val Leu Asp Leu Gly Thr Gly Pro 
            820                 825                 830         


Glu Ala Lys Ile Leu Glu Leu Ile Pro Pro Thr Ser Pro Val Thr Cys 
        835                 840                 845             


Val Asp Ile Arg Pro Thr Ala Gln Pro Ser Gly Cys Trp Asn Val Arg 
    850                 855                 860                 


Thr Thr Phe Leu Glu Leu Asp Tyr Leu Ser Asp Gly Trp Ile Thr Gly 
865                 870                 875                 880 


Val Arg Gly Asp Ile Val Thr Cys Met Leu Ser Leu Gly Ala Ala Ala 
                885                 890                 895     


Ala Gly Lys Ser Met Thr Phe Asp Ala Ala Phe Gln Gln Leu Val Lys 
            900                 905                 910         


Val Leu Thr Lys Ser Thr Ala Asn Val Leu Leu Ile Gln Val Asn Cys 
        915                 920                 925             


Pro Thr Asp Val Ile Arg Thr Ile Lys Gly Tyr Leu Glu Ile Asp Gln 
    930                 935                 940                 


Thr Asn Lys Arg Tyr Arg Phe Pro Lys Phe Gly Arg Asp Glu Pro Tyr 
945                 950                 955                 960 


Ser Asp Met Asp Ser Leu Glu Arg Ile Cys Arg Thr Ala Trp Pro Asn 
                965                 970                 975     


Cys Ser Ile Thr Trp Val Pro Leu Pro Tyr Asp Leu Arg Trp Thr Lys 
            980                 985                 990         


Leu Ala Leu Leu Glu Ser Thr Thr  Leu Ser Ser Ala Ser  Val Arg Ile 
        995                 1000                 1005             


Ala Glu  Leu Met Tyr Lys Tyr  Met Pro Val Met Arg  Ile Asp Ile 
    1010                 1015                 1020             


His Gly  Leu Pro Met Glu Lys  Gln Gly Ser Phe Ile  Val Gly Gln 
    1025                 1030                 1035             


Asn Cys  Ser Leu Thr Ile Pro  Gly Phe Asn Ala Gln  Asp Val Phe 
    1040                 1045                 1050             


Asn Cys  Tyr Phe Asn Ser Ala  Leu Ala Phe Ser Thr  Glu Asp Val 
    1055                 1060                 1065             


Ser Ser  Ala Met Ile Pro Gln  Val Ala Ala Gln Phe  Asn Ala Asn 
    1070                 1075                 1080             


Lys Gly  Glu Trp Ser Leu Asp  Met Val Phe Ser Asp  Ala Gly Ile 
    1085                 1090                 1095             


Tyr Thr  Met Gln Ala Leu Val  Gly Ser Asn Ala Ser  Pro Val Ser 
    1100                 1105                 1110             


Leu Gly  Ser Phe Val Val Asp  Ser Pro Asp Val Asp  Ile Thr Asp 
    1115                 1120                 1125             


Ala Trp  Pro Ala Gln Leu Asp  Phe Thr Ile Ala Gly  Thr Asp Val 
    1130                 1135                 1140             


Asn Ile  Thr Val Asn Pro Tyr  Tyr Arg Leu Met Ala  Phe Val Lys 
    1145                 1150                 1155             


Ile Asp  Gly Gln Trp Gln Ile  Ala Asn Pro Asp Lys  Phe Gln Phe 
    1160                 1165                 1170             


Phe Ser  Ser Ser Thr Gly Thr  Leu Val Met Asn Val  Lys Leu Asp 
    1175                 1180                 1185             


Ile Ala  Asp Arg Tyr Leu Leu  Tyr Tyr Ile Arg Asp  Val Gln Ser 
    1190                 1195                 1200             


Arg Glu  Val Gly Phe Tyr Ile  Gln His Pro Leu Arg  Leu Leu Asn 
    1205                 1210                 1215             


Thr Ile  Thr Leu Pro Thr Asn  Glu Asp Leu Phe Leu  Ser Ala Pro 
    1220                 1225                 1230             


Asp Met  Arg Glu Trp Ala Val  Lys Glu Ser Gly Asn  Thr Ile Cys 
    1235                 1240                 1245             


Ile Leu  Asn Ser Gln Gly Phe  Val Pro Pro Gln Asp  Trp Asp Ile 
    1250                 1255                 1260             


Leu Thr  Asp Thr Ile Ser Trp  Ser Pro Ser Leu Pro  Thr Tyr Val 
    1265                 1270                 1275             


Val Pro  Pro Gly Asp Tyr Thr  Leu Thr Pro Leu 
    1280                 1285                 


<210>  16
<211>  1275
<212>  PRT
<213>  Mammalian Orthoreovirus

<400>  16

Met Lys Arg Ile Pro Arg Lys Thr Lys Gly Lys Ser Ser Gly Lys Gly 
1               5                   10                  15      


Asn Asp Ser Thr Asp Arg Ala Asp Asp Gly Ser Ser Gln Leu Arg Asp 
            20                  25                  30          


Lys Gln Asn Asn Lys Thr Gly Pro Ala Thr Thr Glu Pro Gly Met Ser 
        35                  40                  45              


Asn Arg Glu Gln Tyr Lys Ala Arg Pro Ser Ile Ala Ser Val Gln Arg 
    50                  55                  60                  


Ala Thr Glu Ser Ala Glu Leu Pro Ile Lys Asn Asn Asp Glu Gly Thr 
65                  70                  75                  80  


Pro Asp Lys Lys Gly Asn Thr Lys Gly Asp Ser Ile Ser Glu His Ser 
                85                  90                  95      


Glu Ala Lys Asp Glu Ala Asp Glu Ala Thr Lys Lys Gln Ala Lys Asp 
            100                 105                 110         


Thr Asp Lys Gly Lys Ala Gln Val Thr Tyr Ser Asp Thr Gly Ile Asn 
        115                 120                 125             


Asn Ala Asn Glu Leu Ser Arg Ser Gly Asn Val Asp Asn Glu Gly Gly 
    130                 135                 140                 


Ser Asn Gln Lys Pro Met Ser Thr Arg Ile Ala Glu Ala Thr Ser Ala 
145                 150                 155                 160 


Ile Val Ser Lys His Pro Ala Arg Val Gly Leu Pro Pro Thr Ala Ser 
                165                 170                 175     


Ser Gly His Gly Tyr Gln Cys His Val Cys Ser Ala Val Leu Phe Ser 
            180                 185                 190         


Pro Leu Asp Leu Asp Ala His Val Ala Ser His Gly Leu His Gly Asn 
        195                 200                 205             


Met Thr Leu Thr Ser Ser Glu Ile Gln Arg His Ile Thr Glu Phe Ile 
    210                 215                 220                 


Ser Ser Trp Gln Asn His Pro Ile Val Gln Val Ser Ala Asp Val Glu 
225                 230                 235                 240 


Asn Lys Lys Thr Ala Gln Leu Leu His Ala Asp Thr Pro Arg Leu Val 
                245                 250                 255     


Thr Trp Asp Ala Gly Leu Cys Thr Ser Phe Lys Ile Val Pro Ile Val 
            260                 265                 270         


Pro Ala Gln Val Pro Gln Asp Val Leu Ala Tyr Thr Phe Phe Thr Ser 
        275                 280                 285             


Ser Tyr Ala Ile Gln Ser Pro Phe Pro Glu Ala Ala Val Ser Arg Ile 
    290                 295                 300                 


Val Val His Thr Arg Trp Ala Ser Asn Val Asp Phe Asp Arg Asp Ser 
305                 310                 315                 320 


Ser Val Val Met Ala Pro Pro Thr Glu Asn Asn Ile His Leu Phe Lys 
                325                 330                 335     


Gln Leu Leu Asn Thr Asp Thr Leu Ser Val Arg Gly Ala Asn Pro Leu 
            340                 345                 350         


Met Phe Arg Ala Asn Val Leu His Met Leu Leu Glu Phe Val Leu Asp 
        355                 360                 365             


Asn Leu Tyr Leu Asn Arg His Thr Gly Phe Ser Gln Asp His Thr Pro 
    370                 375                 380                 


Phe Thr Glu Gly Ala Asn Leu Arg Ser Leu Pro Gly Pro Asp Ala Glu 
385                 390                 395                 400 


Lys Trp Tyr Ser Ile Met Tyr Pro Thr Arg Met Gly Thr Pro Asn Val 
                405                 410                 415     


Ser Lys Ile Cys Asn Phe Val Ala Ser Cys Val Arg Asn Arg Val Gly 
            420                 425                 430         


Arg Phe Asp Arg Ala Gln Met Met Asn Gly Ala Met Ser Glu Trp Val 
        435                 440                 445             


Asp Val Phe Glu Thr Ser Asp Ala Leu Thr Val Ser Ile Arg Gly Arg 
    450                 455                 460                 


Trp Met Ala Arg Leu Ala Arg Met Asn Ile Asn Pro Thr Glu Ile Glu 
465                 470                 475                 480 


Trp Ala Leu Thr Glu Cys Ala Gln Gly Tyr Val Thr Val Thr Ser Pro 
                485                 490                 495     


Tyr Ala Pro Ser Val Asn Arg Leu Met Pro Tyr Arg Val Ser Asn Thr 
            500                 505                 510         


Glu Arg Gln Ile Ser Gln Ile Ile Arg Ile Met Asn Ile Gly Asn Asn 
        515                 520                 525             


Ala Thr Val Ile Gln Pro Val Leu Gln Asp Ile Ser Val Leu Leu Gln 
    530                 535                 540                 


Arg Ile Ser Pro Leu Gln Ile Asp Pro Thr Ile Ile Ser Asn Thr Met 
545                 550                 555                 560 


Ser Thr Val Ser Glu Ser Thr Thr Gln Thr Leu Ser Pro Ala Ser Ser 
                565                 570                 575     


Ile Leu Gly Lys Leu Arg Pro Ser Asn Ser Asp Phe Ser Ser Phe Arg 
            580                 585                 590         


Val Ala Leu Ala Gly Trp Leu Tyr Asn Gly Val Val Thr Thr Val Ile 
        595                 600                 605             


Asp Asp Ser Ser Tyr Pro Lys Asp Gly Gly Ser Val Thr Ser Leu Glu 
    610                 615                 620                 


Asn Leu Trp Asp Phe Phe Ile Leu Ala Leu Ala Leu Pro Leu Thr Thr 
625                 630                 635                 640 


Asp Pro Cys Ala Pro Val Lys Ala Phe Met Thr Leu Ala Asn Met Met 
                645                 650                 655     


Val Gly Phe Glu Thr Ile Pro Met Asp Asn Gln Ile Tyr Thr Gln Ser 
            660                 665                 670         


Arg Arg Ala Ser Ala Phe Ser Thr Pro His Thr Trp Pro Arg Cys Phe 
        675                 680                 685             


Met Asn Ile Gln Leu Ile Ser Pro Ile Asp Ala Pro Ile Leu Arg Gln 
    690                 695                 700                 


Trp Ala Glu Ile Ile His Arg Tyr Trp Pro Asn Pro Ser Gln Ile Arg 
705                 710                 715                 720 


Tyr Gly Ala Pro Asn Val Phe Gly Ser Ala Asn Leu Phe Thr Pro Pro 
                725                 730                 735     


Glu Val Leu Leu Leu Pro Ile Asp His Gln Pro Ala Asn Val Thr Thr 
            740                 745                 750         


Pro Thr Leu Asp Phe Thr Asn Glu Leu Thr Asn Trp Arg Ala Arg Val 
        755                 760                 765             


Cys Glu Leu Met Lys Asn Leu Val Asp Asn Gln Arg Tyr Gln Pro Gly 
    770                 775                 780                 


Trp Thr Gln Ser Leu Val Ser Ser Met Arg Gly Thr Leu Asp Lys Leu 
785                 790                 795                 800 


Lys Leu Ile Lys Ser Met Thr Pro Met Tyr Leu Gln Gln Leu Ala Pro 
                805                 810                 815     


Val Glu Leu Ala Val Ile Ala Pro Met Leu Pro Phe Pro Pro Phe Gln 
            820                 825                 830         


Val Pro Tyr Val Arg Leu Asp Arg Asp Arg Ile Pro Thr Met Val Gly 
        835                 840                 845             


Val Thr Arg Gln Ser Arg Asp Thr Ile Ser Gln Pro Ala Leu Ser Leu 
    850                 855                 860                 


Ser Thr Thr Asn Thr Thr Val Gly Val Pro Leu Ala Leu Asp Ala Arg 
865                 870                 875                 880 


Ala Ile Thr Val Ala Leu Leu Ser Gly Lys Tyr Pro Pro Asp Leu Val 
                885                 890                 895     


Thr Asn Val Trp Tyr Ala Asp Ala Ile Tyr Pro Met Tyr Ala Asp Thr 
            900                 905                 910         


Glu Val Phe Ser Asn Leu Gln Arg Asp Met Ile Thr Cys Glu Ala Val 
        915                 920                 925             


Gln Thr Leu Val Thr Leu Val Ala Gln Ile Ser Glu Thr Gln Tyr Pro 
    930                 935                 940                 


Val Asp Arg Tyr Leu Asp Trp Ile Pro Ser Leu Arg Ala Ser Ala Ala 
945                 950                 955                 960 


Thr Ala Ala Thr Phe Ala Glu Trp Val Asn Thr Ser Met Lys Thr Ala 
                965                 970                 975     


Phe Asp Leu Ser Asp Met Leu Leu Glu Pro Leu Leu Ser Gly Asp Pro 
            980                 985                 990         


Arg Met Thr Gln Leu Ala Ile Gln  Tyr Gln Gln Tyr Asn  Gly Arg Thr 
        995                 1000                 1005             


Phe Asn  Val Val Pro Glu Met  Pro Gly Ser Val Ile  Ala Asp Cys 
    1010                 1015                 1020             


Val Gln  Leu Thr Ala Glu Val  Phe Asn His Glu Tyr  Asn Leu Phe 
    1025                 1030                 1035             


Gly Ile  Ala Arg Gly Asp Ile  Ile Ile Gly Arg Val  Gln Ser Thr 
    1040                 1045                 1050             


His Leu  Trp Ser Pro Leu Ala  Pro Pro Pro Asp Leu  Val Phe Asp 
    1055                 1060                 1065             


Arg Asp  Thr Pro Gly Val His  Ile Phe Gly Arg Asp  Cys Arg Ile 
    1070                 1075                 1080             


Ser Phe  Gly Met Asn Gly Ala  Ala Pro Met Ile Arg  Asp Glu Thr 
    1085                 1090                 1095             


Gly Met  Met Val Pro Phe Glu  Gly Asn Trp Ile Phe  Pro Leu Ala 
    1100                 1105                 1110             


Leu Trp  Gln Met Asn Thr Arg  Tyr Phe Asn Gln Gln  Phe Asp Ala 
    1115                 1120                 1125             


Trp Ile  Lys Thr Gly Glu Leu  Arg Ile Arg Ile Glu  Met Gly Ala 
    1130                 1135                 1140             


Tyr Pro  Tyr Met Leu His Tyr  Tyr Asp Pro Arg Gln  Tyr Ala Asn 
    1145                 1150                 1155             


Ala Trp  Asn Leu Thr Ser Ala  Trp Leu Glu Glu Ile  Thr Pro Thr 
    1160                 1165                 1170             


Ser Ile  Pro Ser Val Pro Phe  Met Val Pro Ile Ser  Ser Asp His 
    1175                 1180                 1185             


Asp Ile  Ser Ser Ala Pro Ala  Val Gln Tyr Ile Ile  Ser Thr Glu 
    1190                 1195                 1200             


Tyr Asn  Asp Arg Ser Leu Phe  Cys Thr Asn Ser Ser  Ser Pro Gln 
    1205                 1210                 1215             


Thr Ile  Ala Gly Pro Asp Lys  His Ile Pro Val Glu  Arg Tyr Asn 
    1220                 1225                 1230             


Ile Leu  Thr Asn Pro Asp Ala  Pro Pro Thr Gln Ile  Gln Leu Pro 
    1235                 1240                 1245             


Glu Val  Ile Asp Leu Tyr Asn  Val Val Thr Arg Tyr  Ala Tyr Glu 
    1250                 1255                 1260             


Thr Pro  Pro Ile Thr Ala Val  Val Met Gly Val Pro  
    1265                 1270                 1275 


<210>  17
<211>  736
<212>  PRT
<213>  Mammalian Orthoreovirus

<400>  17

Met Ala Tyr Ile Ala Val Pro Ala Val Val Gly Ser Arg Ala Ser Glu 
1               5                   10                  15      


Ala Ile Gly Leu Leu Glu Ser Phe Gly Val Asp Ala Gly Ala Asp Thr 
            20                  25                  30          


Asn Asp Val Ser Tyr Gln Asp His Asp Tyr Val Leu Asp Gln Leu Gln 
        35                  40                  45              


Tyr Met Leu Asp Gly Tyr Glu Ala Gly Asp Val Ile Asp Ala Leu Val 
    50                  55                  60                  


His Lys Asn Trp Leu His Tyr Ser Val Tyr Cys Leu Leu Pro Pro Lys 
65                  70                  75                  80  


Ser Gln Leu Leu Glu Tyr Trp Lys Ser Asn Pro Ser Ala Ile Pro Asp 
                85                  90                  95      


Asn Val Asp Arg Arg Leu Arg Lys Arg Leu Met Leu Lys Lys Asp Leu 
            100                 105                 110         


Arg Lys Asp Asp Glu Tyr Asn Gln Leu Ala Arg Ala Phe Lys Ile Ser 
        115                 120                 125             


Asp Val Tyr Ala Pro Leu Ile Ser Ser Thr Thr Ser Pro Met Thr Met 
    130                 135                 140                 


Ile Gln Asn Leu Asn Gln Gly Glu Ile Val Tyr Thr Thr Thr Asp Arg 
145                 150                 155                 160 


Val Ile Gly Ala Arg Ile Leu Leu Tyr Ala Pro Arg Lys Tyr Tyr Ala 
                165                 170                 175     


Ser Thr Leu Ser Phe Thr Met Thr Lys Cys Ile Ile Pro Phe Gly Lys 
            180                 185                 190         


Glu Val Gly Arg Ala Pro His Ser Arg Phe Asn Val Gly Thr Phe Pro 
        195                 200                 205             


Ser Ile Ala Thr Pro Lys Cys Phe Val Met Ser Gly Ile Asp Val Glu 
    210                 215                 220                 


Ser Ile Pro Asn Glu Phe Ile Lys Leu Phe Tyr Gln Arg Val Lys Ser 
225                 230                 235                 240 


Val His Ala Asn Ile Leu Asn Asp Ile Ser Pro Gln Ile Leu Ser Asp 
                245                 250                 255     


Met Ile Asn Arg Lys Arg Leu Arg Val His Thr Pro Ser Asp Arg Arg 
            260                 265                 270         


Ala Ala Gln Leu Met His Leu Pro Tyr His Val Lys Arg Gly Ala Ser 
        275                 280                 285             


His Val Asp Val Tyr Lys Val Asp Val Val Asp Val Leu Phe Glu Val 
    290                 295                 300                 


Val Asp Val Ala Asp Gly Leu Arg Asn Val Ser Arg Lys Leu Thr Met 
305                 310                 315                 320 


His Thr Val Pro Val Cys Ile Leu Glu Met Leu Gly Ile Glu Ile Ala 
                325                 330                 335     


Asp Tyr Cys Val Arg Arg Glu Asp Gly Met Phe Ile Asp Trp Phe Leu 
            340                 345                 350         


Leu Leu Thr Met Leu Ser Asp Gly Leu Thr Asp Arg Arg Thr Arg Cys 
        355                 360                 365             


Gln Tyr Leu Ile Asn Pro Ser Ser Val Pro Pro Asp Val Ile Leu Asn 
    370                 375                 380                 


Ile Ser Ile Thr Gly Phe Ile Asn Arg His Thr Ile Asp Val Met Pro 
385                 390                 395                 400 


Asp Thr Tyr Asp Phe Val Lys Pro Ile Gly Ala Val Leu Pro Lys Gly 
                405                 410                 415     


Ser Phe Lys Ser Thr Ile Met Arg Val Leu Asp Ser Ile Ser Ile Leu 
            420                 425                 430         


Gly Val Gln Ile Met Pro Arg Ala His Val Val Asp Ser Asp Glu Val 
        435                 440                 445             


Gly Glu Gln Met Glu Pro Thr Phe Glu His Ala Val Met Glu Ile Tyr 
    450                 455                 460                 


Lys Gly Ile Ala Gly Val Asp Ser Leu Asp Asp Leu Ile Lys Trp Val 
465                 470                 475                 480 


Leu Asn Ser Asp Leu Ile Pro His Asp Asp Arg Leu Gly His Leu Phe 
                485                 490                 495     


Gln Ala Phe Leu Pro Leu Ala Lys Asp Leu Leu Ala Pro Met Ala Arg 
            500                 505                 510         


Lys Phe Tyr Asp Asn Ser Met Ser Glu Gly Arg Leu Leu Thr Phe Ala 
        515                 520                 525             


His Ala Asp Ser Glu Leu Leu Asn Ala Asn Tyr Phe Gly His Leu Leu 
    530                 535                 540                 


Arg Leu Lys Ile Pro Tyr Ile Thr Glu Val Asn Leu Met Ile Arg Lys 
545                 550                 555                 560 


Asn Arg Glu Gly Gly Glu Leu Phe Gln Leu Val Leu Ser His Leu Tyr 
                565                 570                 575     


Lys Met Tyr Ala Thr Ser Ala Gln Pro Lys Trp Phe Gly Ser Leu Leu 
            580                 585                 590         


Arg Leu Leu Ile Cys Pro Trp Leu His Met Glu Lys Leu Ile Gly Glu 
        595                 600                 605             


Ala Asp Pro Ala Ser Thr Ser Ala Glu Ile Gly Trp Tyr Ile Pro Arg 
    610                 615                 620                 


Glu Gln Leu Met Gln Asp Gly Trp Cys Gly Cys Glu Asp Gly Phe Ile 
625                 630                 635                 640 


Pro Tyr Val Arg Ile Arg Ala Pro Lys Leu Val Ile Glu Glu Leu Ala 
                645                 650                 655     


Glu Lys Asn Trp Gly Gln Tyr His Ala Gln Val Ile Ile Thr Asp Gln 
            660                 665                 670         


Leu Val Val Gly Glu Pro Arg Arg Val Ser Ala Lys Ala Val Ile Lys 
        675                 680                 685             


Gly Asn His Leu Pro Val Lys Leu Val Ser Arg Phe Ala Cys Phe Thr 
    690                 695                 700                 


Leu Thr Thr Lys Tyr Glu Met Arg Leu Ser Cys Gly His Ser Thr Gly 
705                 710                 715                 720 


Arg Gly Ala Ala Tyr Asn Ala Arg Leu Ala Phe Arg Ser Asp Leu Ala 
                725                 730                 735     


<210>  18
<211>  708
<212>  PRT
<213>  Mammalian Orthoreovirus

<400>  18

Met Gly Asn Ala Ser Ser Ile Val Gln Thr Ile Asn Val Thr Gly Asp 
1               5                   10                  15      


Gly Asn Val Phe Lys Pro Ser Ala Glu Thr Ser Ser Thr Ala Val Pro 
            20                  25                  30          


Ser Leu Ser Leu Ser Pro Gly Met Leu Asn Pro Gly Gly Val Pro Trp 
        35                  40                  45              


Ile Ala Ile Gly Asp Glu Thr Ser Val Thr Ser Pro Gly Ala Leu Arg 
    50                  55                  60                  


Arg Met Thr Ser Arg Asp Ile Pro Glu Thr Ala Ile Ile Asn Thr Asp 
65                  70                  75                  80  


Asn Ser Ser Gly Ala Val Pro Ser Glu Ser Ala Leu Val Pro Tyr Asn 
                85                  90                  95      


Asp Glu Pro Leu Val Val Val Thr Glu His Ala Ile Ala Asn Phe Thr 
            100                 105                 110         


Lys Ala Glu Met Ala Leu Glu Phe Asn Arg Glu Phe Leu Asp Lys Leu 
        115                 120                 125             


Arg Val Leu Ser Val Ser Pro Lys Tyr Ser Asp Leu Leu Thr Tyr Val 
    130                 135                 140                 


Asp Cys Tyr Val Gly Val Ser Ala Arg Gln Ala Leu Asn Asn Phe Gln 
145                 150                 155                 160 


Lys Gln Val Pro Val Ile Thr Pro Thr Arg Gln Thr Met Tyr Val Asp 
                165                 170                 175     


Ser Ile Gln Ala Ala Leu Lys Ala Leu Glu Lys Trp Glu Ile Asp Leu 
            180                 185                 190         


Arg Val Ala Gln Thr Leu Leu Pro Thr Asn Val Pro Ile Gly Glu Val 
        195                 200                 205             


Ser Cys Pro Met Gln Ser Val Val Lys Leu Leu Asp Asp Gln Leu Pro 
    210                 215                 220                 


Asp Asp Ser Leu Ile Arg Arg Tyr Pro Arg Glu Ala Ala Val Ala Leu 
225                 230                 235                 240 


Ala Lys Arg Asn Gly Gly Ile Gln Trp Met Asp Val Ser Glu Gly Thr 
                245                 250                 255     


Val Met Asn Glu Ala Val Asn Ala Val Ala Ala Ser Ala Leu Ala Pro 
            260                 265                 270         


Ser Ala Ser Ser Pro Pro Leu Glu Glu Lys Ser Lys Leu Thr Glu Gln 
        275                 280                 285             


Ala Met Asp Leu Val Thr Ala Ala Glu Pro Glu Ile Ile Ala Ser Leu 
    290                 295                 300                 


Val Pro Val Pro Ala Pro Val Phe Ala Ile Pro Pro Lys Pro Ala Asp 
305                 310                 315                 320 


Tyr Asn Val Arg Thr Leu Lys Ile Asp Glu Ala Thr Trp Leu Arg Met 
                325                 330                 335     


Ile Pro Lys Thr Met Thr Thr Pro Phe Gln Ile Gln Val Thr Asp Asn 
            340                 345                 350         


Thr Ser Thr Arg Trp His Met Asn Leu Arg Gly Gly Thr Arg Val Val 
        355                 360                 365             


Asn Leu Asp Gln Ile Ala Pro Met Arg Phe Val Leu Asp Leu Gly Gly 
    370                 375                 380                 


Lys Ser Tyr Lys Glu Thr Ser Trp Asn Pro Asn Gly Lys Arg Val Gly 
385                 390                 395                 400 


Phe Ile Val Phe Gln Ser Lys Ile Pro Phe Glu Leu Trp Thr Ala Ala 
                405                 410                 415     


Ser Gln Ile Gly Gln Ala Thr Val Val Asn Tyr Val Gln Leu Tyr Ala 
            420                 425                 430         


Glu Asp Ser Ser Phe Thr Asp Gln Ser Ile Ile Ala Thr Thr Ser Leu 
        435                 440                 445             


Ala Tyr Asn Tyr Glu Pro Glu Gln Leu Asn Lys Thr Asp Pro Glu Met 
    450                 455                 460                 


Asn Tyr Tyr Leu Leu Ala Thr Phe Ile Asp Ser Ala Glu Ile Asn Pro 
465                 470                 475                 480 


Ser Asn Met Thr Gln Pro Asp Val Trp Asp Ala Leu Leu Thr Met Ser 
                485                 490                 495     


Pro Leu Ser Ala Gly Glu Val Thr Val Lys Gly Ala Val Val Ser Glu 
            500                 505                 510         


Val Thr Pro Ala Asp Leu Val Gly Ser Tyr Thr Pro Glu Ser Leu Asn 
        515                 520                 525             


Ala Ser Leu Pro Asn Asp Ala Ala Arg Cys Met Ile Asp Arg Ala Ser 
    530                 535                 540                 


Lys Ile Ala Glu Ala Ile Lys Ile Asp Asp Asp Ala Gly Pro Asp Glu 
545                 550                 555                 560 


Tyr Ser Pro Asn Ser Val Pro Ile Gln Gly Gln Leu Ala Ile Ser Gln 
                565                 570                 575     


Leu Glu Thr Gly Tyr Gly Val Arg Ile Phe Asn Pro Lys Gly Ile Leu 
            580                 585                 590         


Ser Lys Ile Ala Ser Arg Ala Met Gln Ala Phe Ile Gly Asp Pro Ser 
        595                 600                 605             


Thr Ile Ile Thr Gln Ala Ala Pro Val Leu Ser Asp Lys Asn Asn Trp 
    610                 615                 620                 


Ile Ala Leu Ala Gln Gly Val Lys Thr Ser Leu Arg Thr Lys Ser Leu 
625                 630                 635                 640 


Ser Ala Gly Val Lys Thr Ala Val Ser Lys Leu Ser Ser Ser Glu Ser 
                645                 650                 655     


Ile Gln Ser Trp Thr Gln Gly Phe Leu Asp Lys Val Ser Thr His Phe 
            660                 665                 670         


Pro Ala Pro Arg Ser Asp Cys Pro Gln Ser Gly Asp Ser Asp Gly Gly 
        675                 680                 685             


Ser Ala Arg Arg Leu Lys Arg Asp Ser Tyr Ala Gly Val Val Lys Arg 
    690                 695                 700                 


Gly Tyr Thr Arg 
705             


<210>  19
<211>  721
<212>  PRT
<213>  Mammalian Orthoreovirus

<400>  19

Met Ala Ser Phe Lys Gly Phe Ser Ala Asn Thr Val Pro Val Ser Lys 
1               5                   10                  15      


Ala Lys Arg Asp Ile Ser Ala Leu Ala Ala Thr Pro Gly Phe His Ser 
            20                  25                  30          


Gln Ser Phe Thr Pro Ser Val Asp Met Ser Gln Ser Arg Glu Phe Leu 
        35                  40                  45              


Thr Lys Ala Ile Glu Gln Gly Ser Met Ser Ile Pro Tyr Gln His Val 
    50                  55                  60                  


Asn Val Pro Lys Val Asp Arg Lys Val Val Ser Leu Val Val Arg Pro 
65                  70                  75                  80  


Phe Ser Ser Gly Ala Phe Ser Ile Ser Gly Val Ile Ser Pro Ala His 
                85                  90                  95      


Ala Tyr Leu Leu Asp Cys Leu Pro Gln Leu Glu Gln Ala Met Ala Phe 
            100                 105                 110         


Val Ala Ser Pro Glu Ser Phe Gln Ala Ser Asp Val Ala Lys Arg Phe 
        115                 120                 125             


Ala Ile Lys Pro Gly Met Ser Leu Gln Asp Ala Ile Thr Ala Phe Ile 
    130                 135                 140                 


Asn Phe Val Ser Ala Met Leu Lys Met Thr Val Thr Arg Gln Asn Phe 
145                 150                 155                 160 


Asp Val Ile Val Ala Glu Ile Glu Arg Leu Ala Ser Thr Ser Val Ser 
                165                 170                 175     


Ala Arg Thr Glu Glu Ala Lys Val Ala Asp Glu Glu Leu Met Leu Phe 
            180                 185                 190         


Gly Leu Asp His Arg Gly Pro Gln Gln Leu Asp Ile Ser Asp Ala Lys 
        195                 200                 205             


Gly Ile Met Lys Ala Val Asp Ile Gln Thr Thr His Asp Val His Leu 
    210                 215                 220                 


Ala Pro Gly Val Gly Asn Ile Asp Pro Glu Ile Tyr Asn Glu Gly Arg 
225                 230                 235                 240 


Phe Met Phe Met Gln His Lys Pro Leu Ala Ala Asp Gln Ser Tyr Phe 
                245                 250                 255     


Thr Leu Glu Thr Ala Asp Tyr Phe Lys Ile Tyr Pro Thr Tyr Asp Glu 
            260                 265                 270         


His Asp Gly Arg Met Ala Asp Gln Lys Gln Ser Gly Leu Ile Leu Cys 
        275                 280                 285             


Thr Lys Asp Glu Val Leu Ala Glu Gln Thr Ile Phe Lys Leu Asp Thr 
    290                 295                 300                 


Pro Asp Asp Lys Thr Val His Leu Leu Asp Arg Asp Asp Asp His Val 
305                 310                 315                 320 


Val Ala Arg Phe Thr Lys Val Phe Ile Glu Asp Val Ala Pro Gly His 
                325                 330                 335     


His Thr Ala Gln Arg Ser Gly Gln Arg Ser Val Leu Asp Asp Leu Tyr 
            340                 345                 350         


Ala Asn Thr Gln Val Ile Ser Ile Thr Ser Ala Ala Leu Lys Trp Val 
        355                 360                 365             


Val Lys His Gly Val Ser Asp Gly Ile Val Asn Arg Lys Asn Val Lys 
    370                 375                 380                 


Val Cys Val Gly Phe Asp Pro Leu Tyr Thr Leu Ser Thr His Asn Gly 
385                 390                 395                 400 


Ile Ser Leu Cys Ala Leu Leu Met Asp Glu Lys Leu Ser Val Leu Asn 
                405                 410                 415     


Ser Ala Cys Arg Met Thr Leu Arg Ser Leu Met Lys Thr Arg Arg Asp 
            420                 425                 430         


Ala Asp Ala His Arg Ala Phe Gln Arg Val Leu Ser Gln Gly Tyr Thr 
        435                 440                 445             


Ser Leu Met Cys Tyr Tyr His Pro Ser Arg Lys Leu Ala Tyr Gly Glu 
    450                 455                 460                 


Val Leu Phe Pro Glu Arg Ser Asn Asp Val Val Asp Gly Ile Lys Leu 
465                 470                 475                 480 


Gln Leu Asp Ala Ser Arg His Cys His Glu Cys Pro Val Leu Gln Gln 
                485                 490                 495     


Lys Val Val Glu Leu Glu Lys Gln Ile Val Met Gln Lys Ser Ile Gln 
            500                 505                 510         


Ser Asp Thr Ala Pro Ile Ala Leu Gln Pro Leu Leu Ser Gln Leu Arg 
        515                 520                 525             


Glu Leu Ser Ser Glu Val Thr Arg Leu Gln Met Glu Leu Ser Arg Ala 
    530                 535                 540                 


Gln Ser Leu Asn Ala Gln Leu Glu Ala Asp Val Lys Ser Ala Gln Ser 
545                 550                 555                 560 


Cys Ser Leu Asp Met Tyr Leu Arg Tyr His Thr Cys Ile Asn Gly His 
                565                 570                 575     


Ala Lys Glu Asp Glu Leu Leu Asp Ala Val Arg Val Ala Pro Asp Val 
            580                 585                 590         


Arg Arg Gln Ile Met Asp Arg Arg Ser Glu Val Arg Lys Gly Trp Cys 
        595                 600                 605             


Glu Arg Ile Ser Lys Glu Ala Ser Ala Glu Cys Gln Thr Val Ile Asp 
    610                 615                 620                 


Glu Leu Thr Leu Met Asn Gly Lys Gln Ala Gln Glu Ile Ile Glu Leu 
625                 630                 635                 640 


Arg Asp Ser Ala Glu Asn Tyr Glu Lys Gln Ile Ala Glu Leu Val Ser 
                645                 650                 655     


Thr Ile Thr Gln Asn Gln Ile Thr Tyr Gln Gln Glu Leu Gln Ala Leu 
            660                 665                 670         


Val Ala Lys Asn Val Glu Leu Asp Thr Leu Asn Gln Arg Gln Ala Arg 
        675                 680                 685             


Ser Leu Arg Ile Thr Pro Ser Leu Leu Ser Val Thr Pro Thr Asp Ser 
    690                 695                 700                 


Val Asp Gly Ala Ala Asp Leu Ile Asp Phe Ser Val Pro Thr Asp Glu 
705                 710                 715                 720 


Leu 
    


<210>  20
<211>  471
<212>  PRT
<213>  Mammalian Orthoreovirus

<400>  20

Met Asp Ala Ser Leu Ile Ser Glu Ile Arg Arg Ile Val Leu Gln Leu 
1               5                   10                  15      


Thr Gln Ser Asn Asn Gly Ser Ile Asn Lys Glu Leu Lys Glu Ile Lys 
            20                  25                  30          


Glu Gln Val Glu Ile Asn Ala Thr Asp Ile Arg Asn Thr Asn Leu Lys 
        35                  40                  45              


Leu Asp Gly Ile Arg Gly Gln Val Thr Ser Ile Ser Asp Ser Ile Ala 
    50                  55                  60                  


Ala Ile Glu Arg Arg Leu Gly Glu Val Asp Gly Arg Phe Val Val Ile 
65                  70                  75                  80  


Ala Asn Gln Ile Thr Gln Leu Ser Asn Ser Val Gly Gln Asn Thr Gln 
                85                  90                  95      


Asp Ile Ser Ala Leu Gly Asp Arg Leu Asn Val Val Glu Pro Arg Ile 
            100                 105                 110         


Asp Asp Leu Asp Thr Phe Ala Ser Asn Leu Val Gly Arg Thr Ser Thr 
        115                 120                 125             


Leu Glu Ala Asp Val Arg Gly Ile Arg Thr Glu Leu Ser Ala Leu Thr 
    130                 135                 140                 


Thr Arg Val Thr Thr Glu Val Ala Arg Leu Asp Ala Leu Ile Ser Ala 
145                 150                 155                 160 


Gly Gln Ser Ser Leu Thr Ser Leu Ser Ser Arg Leu Asp Ala Val Glu 
                165                 170                 175     


Ala Ala Met Ile Thr Thr Ala Gly Arg Gly Leu Arg Lys Asp Gly Asn 
            180                 185                 190         


Thr Leu Asn Ile Ile Val Gly Asp Gly Met Trp Phe Asp Asn Ser Asn 
        195                 200                 205             


Gln Leu Gln Leu Asp Leu Ser Asn Gln Ala Lys Gly Val Gly Phe Glu 
    210                 215                 220                 


Gly Gly Gly Val Val Ala Lys Ile Asp Thr Asn Tyr Phe Ser Tyr Asn 
225                 230                 235                 240 


Ser Asn Gly Glu Ile Thr Leu Val Gly Gln Ile Asn Gly Leu Pro Ala 
                245                 250                 255     


Arg Val Ser Thr Leu Glu Ser Leu Lys Ile Asp Thr Val Leu Pro Pro 
            260                 265                 270         


Leu Thr Val Ser Glu Ala Asp Gly Ala Arg Asn Leu Gly Leu Gly Tyr 
        275                 280                 285             


Glu Thr Asp Asp Phe Thr Val Thr Asn Ser Met Leu Ser Leu Arg Ser 
    290                 295                 300                 


Arg Leu Thr Leu Pro Thr Tyr Arg Tyr Pro Leu Glu Leu Asp Ala Ser 
305                 310                 315                 320 


Ile Asn Arg Val Gln Ile Ala Glu Arg Phe Gly Met Arg Val Gly Ser 
                325                 330                 335     


Trp Thr Gly Gln Leu Gln Tyr Gln His Pro Gln Leu Asn Trp Gln Ala 
            340                 345                 350         


Asn Val Thr Ile Asn Leu Met Lys Val Asp Asp Trp Leu Val Leu Ser 
        355                 360                 365             


Phe Thr Gln Met Thr Thr Ser Gly Ile Met Ala Asp Gly Lys Phe Thr 
    370                 375                 380                 


Ile Asn Phe Ser Ala Gly Leu Ser Ser Gly Trp Gln Thr Gly Glu Thr 
385                 390                 395                 400 


Gln Pro Ser Ser Ile Thr Asp Pro Leu Ser Thr Thr Phe Ala Ala Val 
                405                 410                 415     


Gln Tyr Leu Lys Ala Asn Gly Thr Arg Val Asp Ala Phe Arg Ile Met 
            420                 425                 430         


Gly Val Ser Glu Trp Val Asp Gly Glu Leu Glu Ile Lys Asn Tyr Gly 
        435                 440                 445             


Gly Thr Tyr Thr Gly His Thr Gln Val Tyr Trp Ala Pro Trp Thr Ile 
    450                 455                 460                 


Met Tyr Pro Cys Asn Val Arg 
465                 470     


<210>  21
<211>  418
<212>  PRT
<213>  Mammalian Orthoreovirus

<400>  21

Met Ala Arg Ala Ala Phe Leu Phe Lys Thr Val Gly Phe Gly Gly Leu 
1               5                   10                  15      


Gln Asn Val Pro Ile Asn Asp Glu Leu Ser Ser His Leu Leu Arg Ala 
            20                  25                  30          


Gly Asn Ser Pro Trp Gln Leu Thr Gln Phe Leu Asp Trp Ile Ser Leu 
        35                  40                  45              


Gly Arg Gly Leu Ala Thr Ser Ala Leu Val Pro Thr Ala Gly Ser Arg 
    50                  55                  60                  


Tyr Tyr Gln Met Ser Cys Leu Leu Ser Gly Thr Leu Gln Ile Pro Phe 
65                  70                  75                  80  


Arg Pro Asn His Arg Trp Gly Asp Ala Arg Phe Leu Arg Leu Val Trp 
                85                  90                  95      


Ser Ala Pro Thr Leu Asp Gly Leu Val Val Ala Pro Pro Gln Val Leu 
            100                 105                 110         


Ala Gln Pro Ala Leu Gln Ala Gln Ala Asp Arg Val Tyr Asp Cys Asp 
        115                 120                 125             


Asp Tyr Pro Phe Leu Ala Arg Asp Pro Arg Phe Lys His Arg Val Tyr 
    130                 135                 140                 


Gln Gln Leu Ser Ala Val Thr Leu Leu Asn Leu Thr Gly Phe Gly Pro 
145                 150                 155                 160 


Ile Ser Tyr Val Arg Val Asp Glu Ala Met Trp Ser Gly Asp Val Asn 
                165                 170                 175     


Gln Leu Leu Met Asn Tyr Phe Gly His Thr Phe Ala Glu Ile Ala Tyr 
            180                 185                 190         


Thr Leu Cys Gln Ala Ser Ala Asn Arg Pro Trp Glu His Asp Gly Thr 
        195                 200                 205             


Tyr Ala Arg Met Thr Gln Ile Ile Leu Ser Leu Phe Trp Leu Ser Tyr 
    210                 215                 220                 


Val Gly Val Ile His Gln Gln Asn Thr Tyr Arg Thr Phe Tyr Phe Gln 
225                 230                 235                 240 


Cys Asn Arg Arg Gly Asp Ala Ala Glu Val Trp Ile Leu Ser Cys Ser 
                245                 250                 255     


Leu Asn His Ser Ala Gln Ile Arg Pro Gly Asn Arg Ser Leu Phe Val 
            260                 265                 270         


Met Pro Thr Ser Pro Asp Trp Asn Met Asp Val Asn Leu Ile Leu Ser 
        275                 280                 285             


Ser Thr Leu Thr Gly Cys Leu Cys Ser Ser Ser Gln Leu Pro Leu Ile 
    290                 295                 300                 


Asp Asn Asn Ser Val Pro Ala Val Ser Arg Asn Ile His Gly Trp Thr 
305                 310                 315                 320 


Gly Arg Ala Gly Asn Gln Leu His Gly Phe Gln Val Arg Arg Met Val 
                325                 330                 335     


Thr Glu Phe Cys Asp Arg Leu Arg Arg Asp Gly Val Met Thr Gln Ala 
            340                 345                 350         


Gln Gln Asn Gln Val Glu Ala Leu Ala Asp Gln Thr Gln Gln Phe Lys 
        355                 360                 365             


Arg Asp Gln Leu Glu Ala Trp Ala Arg Glu Asp Asp Gln Tyr Asn Gln 
    370                 375                 380                 


Ala His Pro Asn Ser Pro Met Phe Arg Thr Lys Pro Phe Thr Asn Ala 
385                 390                 395                 400 


Gln Trp Gly Arg Gly Asn Thr Gly Ala Thr Ser Ala Ala Ile Ala Ala 
                405                 410                 415     


Leu Ile 
        


<210>  22
<211>  366
<212>  PRT
<213>  Mammalian Orthoreovirus

<400>  22

Met Ala Ser Ser Leu Arg Ala Ala Ile Ser Lys Ile Lys Arg Asp Asp 
1               5                   10                  15      


Val Gly Gln Gln Val Cys Pro Asn Tyr Val Met Leu Arg Ser Ser Val 
            20                  25                  30          


Thr Thr Lys Val Val Arg Asn Val Val Glu Tyr Gln Ile Arg Thr Gly 
        35                  40                  45              


Gly Phe Phe Ser Cys Leu Ala Met Leu Arg Pro Leu Gln Tyr Ala Lys 
    50                  55                  60                  


Arg Glu Arg Leu Leu Gly Gln Arg Asn Leu Glu Arg Ile Ser Thr Arg 
65                  70                  75                  80  


Asp Ile Leu Gln Thr Arg Asp Leu His Ser Leu Cys Met Pro Thr Pro 
                85                  90                  95      


Asp Ala Pro Met Ser Ser His Gln Ala Val Thr Met Arg Glu Leu Ile 
            100                 105                 110         


Cys Ser Tyr Phe Lys Val Asp His Thr Asp Gly Leu Lys Tyr Ile Pro 
        115                 120                 125             


Met Asp Glu Lys Tyr Ser Pro Ser Ser Leu Ala Arg Leu Phe Thr Met 
    130                 135                 140                 


Gly Met Ala Gly Leu His Ile Thr Thr Glu Pro Ser Tyr Lys Arg Val 
145                 150                 155                 160 


Pro Ile Met His Leu Ala Ala Asp Leu Asp Cys Met Thr Leu Ala Leu 
                165                 170                 175     


Pro Tyr Met Ile Thr Leu Asp Gly Asp Thr Val Val Pro Val Ala Pro 
            180                 185                 190         


Thr Leu Ser Ala Glu Gln Leu Leu Asp Asp Gly Leu Lys Gly Met Ala 
        195                 200                 205             


Cys Met Asp Ile Ser Tyr Gly Cys Glu Val Asp Ala Asn Asn Arg Ser 
    210                 215                 220                 


Ala Gly Asp Gln Ser Met Asp Ser Ser Arg Cys Ile Asn Glu Leu Tyr 
225                 230                 235                 240 


Cys Glu Glu Thr Ala Glu Ala Ile Cys Val Leu Lys Thr Cys Leu Val 
                245                 250                 255     


Leu Asn Cys Met Gln Phe Lys Leu Glu Met Asp Asp Leu Ala His Asn 
            260                 265                 270         


Ala Ala Glu Leu Asp Lys Ile Gln Met Met Ile Pro Phe Ser Glu Arg 
        275                 280                 285             


Val Phe Arg Met Ala Ser Ala Phe Ala Thr Ile Asp Val Gln Cys Phe 
    290                 295                 300                 


Arg Phe Cys Val Met Met Lys Asp Lys Asn Leu Lys Ile Asp Met Arg 
305                 310                 315                 320 


Glu Thr Met Arg Leu Trp Thr Arg Ser Ala Leu Asp Glu Ser Val Val 
                325                 330                 335     


Thr Ser Ser Leu Ser Ile Ser Leu Asp Arg Gly Arg Trp Val Ala Ala 
            340                 345                 350         


Asp Thr Asn Asp Ala Arg Leu Leu Val Phe Pro Ile Arg Val 
        355                 360                 365     


<210>  23
<211>  365
<212>  PRT
<213>  Mammalian Orthoreovirus

<400>  23

Met Glu Val Cys Leu Pro Asn Gly His Gln Ile Val Asp Trp Ile Asn 
1               5                   10                  15      


Asn Ala Phe Glu Gly Arg Val Ser Ile Tyr Ser Ala Gln Gln Gly Trp 
            20                  25                  30          


Asp Lys Thr Ile Ser Ala Gln Pro Asp Met Met Val Cys Gly Ser Ala 
        35                  40                  45              


Val Val Cys Met His Cys Leu Gly Val Val Gly Ser Leu Gln Arg Lys 
    50                  55                  60                  


Leu Lys His Leu Pro His His Lys Cys Asn Gln Gln Leu Arg Glu Gln 
65                  70                  75                  80  


Asp Tyr Val Asp Leu Gln Phe Ala Asp Arg Val Thr Ala His Trp Lys 
                85                  90                  95      


Arg Gly Met Leu Ser Phe Val Ser Gln Met His Ala Val Met Asn Asp 
            100                 105                 110         


Val Thr Pro Glu Glu Leu Glu Arg Val Arg Thr Asp Gly Gly Ile Leu 
        115                 120                 125             


Ala Glu Leu Asp Trp Leu Lys Val Glu Ser Gly Ser Met Phe Arg Ser 
    130                 135                 140                 


Ile His Ser Ser Trp Thr Asp Pro Leu Gln Val Val Glu Asp Leu Asp 
145                 150                 155                 160 


Thr Gln Leu Asp Arg Tyr Trp Thr Ala Leu Asn Leu Met Ile Asp Ser 
                165                 170                 175     


Ser Asp Leu Val Pro Asn Phe Met Met Arg Asp Pro Ser His Ala Phe 
            180                 185                 190         


Asn Gly Val Lys Leu Glu Gly Glu Ala Arg Gln Thr Gln Phe Pro Arg 
        195                 200                 205             


Thr Phe Asp Ser Gly Ser Asn Leu Lys Trp Gly Val Met Val Tyr Asp 
    210                 215                 220                 


Tyr Ser Glu Leu Glu Arg Asp Ser Gln Lys Gly Arg Ser Tyr Arg Lys 
225                 230                 235                 240 


Glu Ile Val Thr Pro Ala Lys Asp Phe Gly His Phe Gly Leu Ser His 
                245                 250                 255     


Tyr Ser Arg Ala Thr Thr Pro Ile Leu Gly Lys Met Pro Ala Val Phe 
            260                 265                 270         


Ser Gly Met Leu Thr Gly Asn Cys Lys Met Tyr Pro Phe Ile Lys Gly 
        275                 280                 285             


Thr Ala Lys Leu Lys Thr Val Lys Lys Leu Val Asp Ala Val Asn His 
    290                 295                 300                 


Thr Trp Gly Phe Glu Lys Ile Arg Tyr Ala Leu Gly Pro Gly Gly Met 
305                 310                 315                 320 


Thr Gly Trp Tyr Asn Arg Thr Met Gln Gln Ala Pro Ile Val Leu Thr 
                325                 330                 335     


Pro Ala Ala Leu Thr Met Phe Pro Asp Met Thr Arg Phe Gly Asp Leu 
            340                 345                 350         


Gln Tyr Pro Ile Thr Ile Gly Asp Pro Ala Val Leu Gly 
        355                 360                 365 


<210>  24
<211>  122
<212>  PRT
<213>  Mammalian Orthoreovirus

<400>  24

Met Gly Arg Ser Thr Arg Asn Ser Lys Lys Ser Lys Asn Lys Ser Arg 
1               5                   10                  15      


Ser Thr Leu Leu Ile Ser Gly Ile Pro Ile Leu Ser Ser Met Gly Ser 
            20                  25                  30          


Glu Asp Lys Leu Leu Ala Ser Val Ile Ala Ser Gln Pro Leu Asn Val 
        35                  40                  45              


Asp Trp Val Lys Trp Met Val Asp Leu Trp Leu Ser Arg Ile Arg Leu 
    50                  55                  60                  


Arg Asn Tyr Leu Thr Gln Leu Ala Arg Thr Leu Lys Thr Tyr Pro Pro 
65                  70                  75                  80  


Trp Val Thr Asp Ser Met Leu Leu Asn Gln Glu Leu Met Thr Trp Ile 
                85                  90                  95      


His Ser His Leu Ile Ser Leu Asp Glu His Pro Leu Trp Arg Gln Met 
            100                 105                 110         


Leu Glu Glu Ser Val Leu Asn Cys Pro His 
        115                 120         


<210>  25
<211>  681
<212>  PRT
<213>  Mammalian Orthoreovirus

<400>  25

Met Ser Gln Ser Arg Glu Phe Leu Thr Lys Ala Ile Glu Gln Gly Ser 
1               5                   10                  15      


Met Ser Ile Pro Tyr Gln His Val Asn Val Pro Lys Val Asp Arg Lys 
            20                  25                  30          


Val Val Ser Leu Val Val Arg Pro Phe Ser Ser Gly Ala Phe Ser Ile 
        35                  40                  45              


Ser Gly Val Ile Ser Pro Ala His Ala Tyr Leu Leu Asp Cys Leu Pro 
    50                  55                  60                  


Gln Leu Glu Gln Ala Met Ala Phe Val Ala Ser Pro Glu Ser Phe Gln 
65                  70                  75                  80  


Ala Ser Asp Val Ala Lys Arg Phe Ala Ile Lys Pro Gly Met Ser Leu 
                85                  90                  95      


Gln Asp Ala Ile Thr Ala Phe Ile Asn Phe Val Ser Ala Met Leu Lys 
            100                 105                 110         


Met Thr Val Thr Arg Gln Asn Phe Asp Val Ile Val Ala Glu Ile Glu 
        115                 120                 125             


Arg Leu Ala Ser Thr Ser Val Ser Ala Arg Thr Glu Glu Ala Lys Val 
    130                 135                 140                 


Ala Asp Glu Glu Leu Met Leu Phe Gly Leu Asp His Arg Gly Pro Gln 
145                 150                 155                 160 


Gln Leu Asp Ile Ser Asp Ala Lys Gly Ile Met Lys Ala Val Asp Ile 
                165                 170                 175     


Gln Thr Thr His Asp Val His Leu Ala Pro Gly Val Gly Asn Ile Asp 
            180                 185                 190         


Pro Glu Ile Tyr Asn Glu Gly Arg Phe Met Phe Met Gln His Lys Pro 
        195                 200                 205             


Leu Ala Ala Asp Gln Ser Tyr Phe Thr Leu Glu Thr Ala Asp Tyr Phe 
    210                 215                 220                 


Lys Ile Tyr Pro Thr Tyr Asp Glu His Asp Gly Arg Met Ala Asp Gln 
225                 230                 235                 240 


Lys Gln Ser Gly Leu Ile Leu Cys Thr Lys Asp Glu Val Leu Ala Glu 
                245                 250                 255     


Gln Thr Ile Phe Lys Leu Asp Thr Pro Asp Asp Lys Thr Val His Leu 
            260                 265                 270         


Leu Asp Arg Asp Asp Asp His Val Val Ala Arg Phe Thr Lys Val Phe 
        275                 280                 285             


Ile Glu Asp Val Ala Pro Gly His His Thr Ala Gln Arg Ser Gly Gln 
    290                 295                 300                 


Arg Ser Val Leu Asp Asp Leu Tyr Ala Asn Thr Gln Val Ile Ser Ile 
305                 310                 315                 320 


Thr Ser Ala Ala Leu Lys Trp Val Val Lys His Gly Val Ser Asp Gly 
                325                 330                 335     


Ile Val Asn Arg Lys Asn Val Lys Val Cys Val Gly Phe Asp Pro Leu 
            340                 345                 350         


Tyr Thr Leu Ser Thr His Asn Gly Ile Ser Leu Cys Ala Leu Leu Met 
        355                 360                 365             


Asp Glu Lys Leu Ser Val Leu Asn Ser Ala Cys Arg Met Thr Leu Arg 
    370                 375                 380                 


Ser Leu Met Lys Thr Arg Arg Asp Ala Asp Ala His Arg Ala Phe Gln 
385                 390                 395                 400 


Arg Val Leu Ser Gln Gly Tyr Thr Ser Leu Met Cys Tyr Tyr His Pro 
                405                 410                 415     


Ser Arg Lys Leu Ala Tyr Gly Glu Val Leu Phe Pro Glu Arg Ser Asn 
            420                 425                 430         


Asp Val Val Asp Gly Ile Lys Leu Gln Leu Asp Ala Ser Arg His Cys 
        435                 440                 445             


His Glu Cys Pro Val Leu Gln Gln Lys Val Val Glu Leu Glu Lys Gln 
    450                 455                 460                 


Ile Val Met Gln Lys Ser Ile Gln Ser Asp Thr Ala Pro Ile Ala Leu 
465                 470                 475                 480 


Gln Pro Leu Leu Ser Gln Leu Arg Glu Leu Ser Ser Glu Val Thr Arg 
                485                 490                 495     


Leu Gln Met Glu Leu Ser Arg Ala Gln Ser Leu Asn Ala Gln Leu Glu 
            500                 505                 510         


Ala Asp Val Lys Ser Ala Gln Ser Cys Ser Leu Asp Met Tyr Leu Arg 
        515                 520                 525             


Tyr His Thr Cys Ile Asn Gly His Ala Lys Glu Asp Glu Leu Leu Asp 
    530                 535                 540                 


Ala Val Arg Val Ala Pro Asp Val Arg Arg Gln Ile Met Asp Arg Arg 
545                 550                 555                 560 


Ser Glu Val Arg Lys Gly Trp Cys Glu Arg Ile Ser Lys Glu Ala Ser 
                565                 570                 575     


Ala Glu Cys Gln Thr Val Ile Asp Glu Leu Thr Leu Met Asn Gly Lys 
            580                 585                 590         


Gln Ala Gln Glu Ile Ile Glu Leu Arg Asp Ser Ala Glu Asn Tyr Glu 
        595                 600                 605             


Lys Gln Ile Ala Glu Leu Val Ser Thr Ile Thr Gln Asn Gln Ile Thr 
    610                 615                 620                 


Tyr Gln Gln Glu Leu Gln Ala Leu Val Ala Lys Asn Val Glu Leu Asp 
625                 630                 635                 640 


Thr Leu Asn Gln Arg Gln Ala Arg Ser Leu Arg Ile Thr Pro Ser Leu 
                645                 650                 655     


Leu Ser Val Thr Pro Thr Asp Ser Val Asp Gly Ala Ala Asp Leu Ile 
            660                 665                 670         


Asp Phe Ser Val Pro Thr Asp Glu Leu 
        675                 680     


