                         SEQUENCE LISTING

<110>  BIONIZ, LLC
 
<120>  MODULATING THE EFFECTS OF GAMMA-C-CYTOKINE 
SIGNALING FOR THE TREATMENT OF ALOPECIA AND ALOPECIA 
ASSOCIATED DISORDERS 

<130>  BION.012WO

<150>  US 62/842,846
<151>  2019-05-03

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1

Ile Lys Glu Phe Leu Gln Arg Phe Ile His Ile Val Gln Ser Ile Ile 
1               5                   10                  15      


Asn Thr Ser 
            


<210>  2
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = D or E

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = E or Q or N

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = S or R

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = I or K

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = L or I

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = Any amino acid

<400>  2

Xaa Phe Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln 
1               5                   10      



<210>  3
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3

Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
1               5                   10                  15      


Asn Thr Ser 
            


<210>  4
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  4

Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile 
1               5                   10                  15      


Ser Thr Leu Thr 
            20  


<210>  5
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  5

Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile 
1               5                   10                  15      


His Gln His Leu Ser 
            20      


<210>  6
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  6

Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr 
1               5                   10                  15      


Ser Lys Cys Ser Ser 
            20      


<210>  7
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  7

Ala Leu Thr Phe Leu Glu Ser Leu Leu Glu Leu Phe Gln Lys Glu Lys 
1               5                   10                  15      


Met Arg Gly Met Arg 
            20      


<210>  8
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  8

Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp 
1               5                   10                  15      


Asn Lys Ile Leu 
            20  


<210>  9
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = E or Q or N or polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = S or R or polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = Non-polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = I or K or non-polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X = L or I or aliphatic amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X = Non-polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X = Charged amino acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X = I or K

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X = Any amino acid

<400>  9

Xaa Xaa Xaa Phe Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa 
            


<210>  10
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = E or Q or N or polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = S or R or polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = Non-polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = I or K or non-polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X = L or I or aliphatic amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X = Non-polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X = Charged amino acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X = Any amino acid

<400>  10

Xaa Xaa Xaa Phe Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Xaa Xaa Ile 
1               5                   10                  15      


Xaa Thr Ser 
            


<210>  11
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 5

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 1

<400>  11

Ala Ile Lys Glu Ala Leu Gln Arg Phe Ile His Ile Val Gln Ser Ile 
1               5                   10                  15      


Ile Asn Thr Ser 
            20  


<210>  12
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 12

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 8

<400>  12

Ile Lys Glu Phe Leu Gln Arg Ala Ile His Ile Ala Gln Ser Ile Ile 
1               5                   10                  15      


Asn Thr Ser 
            


<210>  13
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  R-octenylalanine; Linked to S-pentenylalanine at position 15

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  S-pentenylalanine; Linked to R-octenylalanine at position 8

<400>  13

Ile Lys Glu Phe Leu Gln Arg Ala Ile His Ile Val Gln Ser Ala Ile 
1               5                   10                  15      


Asn Thr Ser 
            


<210>  14
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 12

<400>  14

Ile Lys Glu Phe Leu Gln Arg Phe Ile His Ile Ala Gln Ser Ile Ala 
1               5                   10                  15      


Asn Thr Ser 
            


<210>  15
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  R-octenylalanine; Linked to S-pentenylalanine at position 19

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  S-pentenylalanine; Linked to R-octenylalanine at position 12

<400>  15

Ile Lys Glu Phe Leu Gln Arg Phe Ile His Ile Ala Gln Ser Ile Ile 
1               5                   10                  15      


Asn Thr Ala 
            


<210>  16
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 5

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 1

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 13

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 9

<400>  16

Ala Ile Lys Glu Ala Leu Gln Arg Ala Ile His Ile Ala Gln Ser Ile 
1               5                   10                  15      


Ile Asn Thr Ser 
            20  


<210>  17
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 5

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 1

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  R-octenylalanine; Linked to S-pentenylalanine at position 16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  S-pentenylalanine; Linked to R-octenylalanine at position 8

<400>  17

Ala Ile Lys Glu Ala Leu Gln Arg Ala Ile His Ile Val Gln Ser Ala 
1               5                   10                  15      


Ile Asn Thr Ser 
            20  


<210>  18
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 5

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 1

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 17

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 13

<400>  18

Ala Ile Lys Glu Ala Leu Gln Arg Phe Ile His Ile Ala Gln Ser Ile 
1               5                   10                  15      


Ala Asn Thr Ser 
            20  


<210>  19
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 5

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 1

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  R-octenylalanine; Linked to S-pentenylalanine at position 20

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  S-pentenylalanine; Linked to R-octenylalanine at position 13

<400>  19

Ala Ile Lys Glu Ala Leu Gln Arg Phe Ile His Ile Ala Gln Ser Ile 
1               5                   10                  15      


Ile Asn Thr Ala 
            20  


<210>  20
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 5

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 1

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 13

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 9

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  D stereochemical configuration

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  D stereochemical configuration

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  D stereochemical configuration

<400>  20

Ala Ile Lys Glu Ala Leu Gln Arg Ala Ile His Ile Ala Gln Ser Ile 
1               5                   10                  15      


Ile Asn Thr Ser 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 5

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 1

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  R-octenylalanine; Linked to S-pentenylalanine at position 16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  S-pentenylalanine; Linked to R-octenylalanine at position 9

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  D stereochemical configuration

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  D stereochemical configuration

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  D stereochemical configuration

<400>  21

Ala Ile Lys Glu Ala Leu Gln Arg Ala Ile His Ile Val Gln Ser Ala 
1               5                   10                  15      


Ile Asn Thr Ser 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 5

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 1

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 17

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 13

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  D stereochemical configuration

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  D stereochemical configuration

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  D stereochemical configuration

<400>  22

Ala Ile Lys Glu Ala Leu Gln Arg Phe Ile His Ile Ala Gln Ser Ile 
1               5                   10                  15      


Ala Asn Thr Ser 
            20  



<210>  23
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 8

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 4

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = Any amino acid

<400>  23

Xaa Xaa Xaa Ala Xaa Xaa Xaa Ala Xaa Xaa 
1               5                   10  


<210>  24
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  R-octenylalanine; Linked to S-pentenylalanine at position 10

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  S-pentenylalanine; Linked to R-octenylalanine at position 3

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X = Any amino acid

<400>  24

Xaa Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa 
1               5                   10      



<210>  25
<211>  708
<212>  DNA
<213>  Homo sapiens

<400>  25
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgagccagt tccgggtgtc gccgctggat cggacctgga acctgggcga gacagtggag      120

ctgaagtgcc aggtgctgct gtccaacccg acgtcgggct gctcgtggct cttccagccg      180

cgcggcgccg ccgccagtcc caccttcctc ctatacctct cccaaaacaa gcccaaggcg      240

gccgaggggc tggacaccca gcggttctcg ggcaagaggt tgggggacac cttcgtcctc      300

accctgagcg acttccgccg agagaacgag ggctactatt tctgctcggc cctgagcaac      360

tccatcatgt acttcagcca cttcgtgccg gtcttcctgc cagcgaagcc caccacgacg      420

ccagcgccgc gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc      480

ccagaggcgt gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc      540

tgtgatatct acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg      600

gttatcaccc tttactgcaa ccacaggaac cgaagacgtg tttgcaaatg tccccggcct      660

gtggtcaaat cgggagacaa gcccagcctt tcggcgagat acgtctaa                   708


<210>  26
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  27
<211>  732
<212>  DNA
<213>  Homo sapiens

<400>  27
atgcggccgc ggctgtggct cctcttggcc gcgcagctga cagttctcca tggcaactca       60

gtcctccagc agacccctgc atacataaag gtgcaaacca acaagatggt gatgctgtcc      120

tgcgaggcta aaatctccct cagtaacatg cgcatctact ggctgagaca gcgccaggca      180

ccgagcagtg acagtcacca cgagttcctg gccctctggg attccgcaaa agggactatc      240

cacggtgaag aggtggaaca ggagaagata gctgtgtttc gggatgcaag ccggttcatt      300

ctcaatctca caagcgtgaa gccggaagac agtggcatct acttctgcat gatcgtcggg      360

agccccgagc tgaccttcgg gaagggaact cagctgagtg tggttgattt ccttcccacc      420

actgcccagc ccaccaagaa gtccaccctc aagaagagag tgtgccggtt acccaggcca      480

gagacccaga agggcccact ttgtagcccc atcacccttg gcctgctggt ggctggcgtc      540

ctggttctgc tggtttccct gggagtggcc atccacctgt gctgccggcg gaggagagcc      600

cggcttcgtt tcatgaaaca gcctcaaggg gaaggtatat caggaacctt tgtcccccaa      660

tgcctgcatg gatactacag caatactaca acctcacaga agctgcttaa cccatggatc      720

ctgaaaacat ag                                                          732


<210>  28
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Pro 
        195                 200                 205             


Gln Gly Glu Gly Ile Ser Gly Thr Phe Val Pro Gln Cys Leu His Gly 
    210                 215                 220                 


Tyr Tyr Ser Asn Thr Thr Thr Ser Gln Lys Leu Leu Asn Pro Trp Ile 
225                 230                 235                 240 


Leu Lys Thr 
            


<210>  29
<211>  462
<212>  DNA
<213>  Homo sapiens

<400>  29
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactt ga                         462


<210>  30
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  31
<211>  489
<212>  DNA
<213>  Homo sapiens

<400>  31
atgagaattt cgaaaccaca tttgagaagt atttccatcc agtgctactt gtgtttactt       60

ctaaacagtc attttctaac tgaagctggc attcatgtct tcattttggg ctgtttcagt      120

gcagggcttc ctaaaacaga agccaactgg gtgaatgtaa taagtgattt gaaaaaaatt      180

gaagatctta ttcaatctat gcatattgat gctactttat atacggaaag tgatgttcac      240

cccagttgca aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt      300

gagtccggag atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac      360

agtttgtctt ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag      420

gaaaaaaata ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac      480

acttcttga                                                              489


<210>  32
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  33
<211>  702
<212>  DNA
<213>  Homo sapiens

<400>  33
atggataacc aaggagtaat ctactcagac ctgaatctgc ccccaaaccc aaagaggcag       60

caacgaaaac ctaaaggcaa taaaagctcc attttagcaa ctgaacagga aataacctat      120

gcggaattaa accttcaaaa agcttctcag gattttcaag ggaatgacaa aacctatcac      180

tgcaaagatt taccatcagc tccagagaag ctcattgttg ggatcctggg aattatctgt      240

cttatcttaa tggcctctgt ggtaacgata gttgttattc cctctacatt aatacagagg      300

cacaacaatt cttccctgaa tacaagaact cagaaagcac gtcattgtgg ccattgtcct      360

gaggagtgga ttacatattc caacagttgt tactacattg gtaaggaaag aagaacttgg      420

gaagagagtt tgctggcctg tacttcgaag aactccagtc tgctttctat agataatgaa      480

gaagaaatga aatttctgtc catcatttca ccatcctcat ggattggtgt gtttcgtaac      540

agcagtcatc atccatgggt gacaatgaat ggtttggctt tcaaacatga gataaaagac      600

tcagataatg ctgaacttaa ctgtgcagtg ctacaagtaa atcgacttaa atcagcccag      660

tgtggatctt caataatata tcattgtaag cataagcttt ag                         702


<210>  34
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Asp Asn Gln Gly Val Ile Tyr Ser Asp Leu Asn Leu Pro Pro Asn 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Pro Lys Gly Asn Lys Ser Ser Ile Leu 
            20                  25                  30          


Ala Thr Glu Gln Glu Ile Thr Tyr Ala Glu Leu Asn Leu Gln Lys Ala 
        35                  40                  45              


Ser Gln Asp Phe Gln Gly Asn Asp Lys Thr Tyr His Cys Lys Asp Leu 
    50                  55                  60                  


Pro Ser Ala Pro Glu Lys Leu Ile Val Gly Ile Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Leu Ile Leu Met Ala Ser Val Val Thr Ile Val Val Ile Pro Ser Thr 
                85                  90                  95      


Leu Ile Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys 
            100                 105                 110         


Ala Arg His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser Asn 
        115                 120                 125             


Ser Cys Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser Leu 
    130                 135                 140                 


Leu Ala Cys Thr Ser Lys Asn Ser Ser Leu Leu Ser Ile Asp Asn Glu 
145                 150                 155                 160 


Glu Glu Met Lys Phe Leu Ser Ile Ile Ser Pro Ser Ser Trp Ile Gly 
                165                 170                 175     


Val Phe Arg Asn Ser Ser His His Pro Trp Val Thr Met Asn Gly Leu 
            180                 185                 190         


Ala Phe Lys His Glu Ile Lys Asp Ser Asp Asn Ala Glu Leu Asn Cys 
        195                 200                 205             


Ala Val Leu Gln Val Asn Arg Leu Lys Ser Ala Gln Cys Gly Ser Ser 
    210                 215                 220                 


Ile Ile Tyr His Cys Lys His Lys Leu 
225                 230             


<210>  35
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  35
atggataacc aaggagtaat ctactcagac ctgaatctgc ccccaaaccc aaagaggcag       60

caacgaaaac ctaaaggcaa taaaagctcc attttagcaa ctgaacagga aataacctat      120

gcggaattaa accttcaaaa agcttctcag gattttcaag ggaatgacaa aacctatcac      180

tgcaaagatt taccatcagc tccagagaag ctcattgttg ggatcctggg aattatctgt      240

cttatcttaa tggcctctgt ggtaacgata gttgttattc cctcacgtca ttgtggccat      300

tgtcctgagg agtggattac atattccaac agttgttact acattggtaa ggaaagaaga      360

acttgggaag agagtttgct ggcctgtact tcgaagaact ccagtctgct ttctatagat      420

aatgaagaag aaatgaaatt tctgtccatc atttcaccat cctcatggat tggtgtgttt      480

cgtaacagca gtcatcatcc atgggtgaca atgaatggtt tggctttcaa acatgagata      540

aaagactcag ataatgctga acttaactgt gcagtgctac aagtaaatcg acttaaatca      600

gcccagtgtg gatcttcaat aatatatcat tgtaagcata agctttag                   648


<210>  36
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Asp Asn Gln Gly Val Ile Tyr Ser Asp Leu Asn Leu Pro Pro Asn 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Pro Lys Gly Asn Lys Ser Ser Ile Leu 
            20                  25                  30          


Ala Thr Glu Gln Glu Ile Thr Tyr Ala Glu Leu Asn Leu Gln Lys Ala 
        35                  40                  45              


Ser Gln Asp Phe Gln Gly Asn Asp Lys Thr Tyr His Cys Lys Asp Leu 
    50                  55                  60                  


Pro Ser Ala Pro Glu Lys Leu Ile Val Gly Ile Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Leu Ile Leu Met Ala Ser Val Val Thr Ile Val Val Ile Pro Ser Arg 
                85                  90                  95      


His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser Asn Ser Cys 
            100                 105                 110         


Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser Leu Leu Ala 
        115                 120                 125             


Cys Thr Ser Lys Asn Ser Ser Leu Leu Ser Ile Asp Asn Glu Glu Glu 
    130                 135                 140                 


Met Lys Phe Leu Ser Ile Ile Ser Pro Ser Ser Trp Ile Gly Val Phe 
145                 150                 155                 160 


Arg Asn Ser Ser His His Pro Trp Val Thr Met Asn Gly Leu Ala Phe 
                165                 170                 175     


Lys His Glu Ile Lys Asp Ser Asp Asn Ala Glu Leu Asn Cys Ala Val 
            180                 185                 190         


Leu Gln Val Asn Arg Leu Lys Ser Ala Gln Cys Gly Ser Ser Ile Ile 
        195                 200                 205             


Tyr His Cys Lys His Lys Leu 
    210                 215 


<210>  37
<211>  696
<212>  DNA
<213>  Homo sapiens

<400>  37
atgaataaac aaagaggaac cttctcagaa gtgagtctgg cccaggaccc aaagcggcag       60

caaaggaaac ctaaaggcaa taaaagctcc atttcaggaa ccgaacagga aatattccaa      120

gtagaattaa atcttcaaaa tccttccctg aatcatcaag ggattgataa aatatatgac      180

tgccaaggtt tactgccacc tccagagaag ctcactgccg aggtcctagg aatcatttgc      240

attgtcctga tggccactgt gttaaaaaca atagttctta ttcctttcct ggagcagaac      300

aatttttccc cgaatacaag aacgcagaaa gcacgtcatt gtggccattg tcctgaggag      360

tggattacat attccaacag ttgttattac attggtaagg aaagaagaac ttgggaagag      420

agtttgctgg cctgtacttc gaagaactcc agtctgcttt ctatagataa tgaagaagaa      480

atgaaatttc tggccagcat tttaccttcc tcatggattg gtgtgtttcg taacagcagt      540

catcatccat gggtgacaat aaatggtttg gctttcaaac ataagataaa agactcagat      600

aatgctgaac ttaactgtgc agtgctacaa gtaaatcgac ttaaatcagc ccagtgtgga      660

tcttcaatga tatatcattg taagcataag ctttag                                696


<210>  38
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Asn Lys Gln Arg Gly Thr Phe Ser Glu Val Ser Leu Ala Gln Asp 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Pro Lys Gly Asn Lys Ser Ser Ile Ser 
            20                  25                  30          


Gly Thr Glu Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Pro 
        35                  40                  45              


Ser Leu Asn His Gln Gly Ile Asp Lys Ile Tyr Asp Cys Gln Gly Leu 
    50                  55                  60                  


Leu Pro Pro Pro Glu Lys Leu Thr Ala Glu Val Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Ile Val Leu Met Ala Thr Val Leu Lys Thr Ile Val Leu Ile Pro Phe 
                85                  90                  95      


Leu Glu Gln Asn Asn Phe Ser Pro Asn Thr Arg Thr Gln Lys Ala Arg 
            100                 105                 110         


His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser Asn Ser Cys 
        115                 120                 125             


Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser Leu Leu Ala 
    130                 135                 140                 


Cys Thr Ser Lys Asn Ser Ser Leu Leu Ser Ile Asp Asn Glu Glu Glu 
145                 150                 155                 160 


Met Lys Phe Leu Ala Ser Ile Leu Pro Ser Ser Trp Ile Gly Val Phe 
                165                 170                 175     


Arg Asn Ser Ser His His Pro Trp Val Thr Ile Asn Gly Leu Ala Phe 
            180                 185                 190         


Lys His Lys Ile Lys Asp Ser Asp Asn Ala Glu Leu Asn Cys Ala Val 
        195                 200                 205             


Leu Gln Val Asn Arg Leu Lys Ser Ala Gln Cys Gly Ser Ser Met Ile 
    210                 215                 220                 


Tyr His Cys Lys His Lys Leu 
225                 230     


<210>  39
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  39
atggggtgga ttcgtggtcg gaggtctcga cacagctggg agatgagtga atttcataat       60

tataacttgg atctgaagaa gagtgatttt tcaacacgat ggcaaaagca aagatgtcca      120

gtagtcaaaa gcaaatgtag agaaaatgca tctccatttt ttttctgctg cttcatcgct      180

gtagccatgg gaatccgttt cattattatg gtaacaatat ggagtgctgt attcctaaac      240

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      300

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      360

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      420

gaggaccagg atttacttaa actggtgaag tcatatcatt ggatgggact agtacacatt      480

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca      540

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggctatata      600

gaaaactgtt caactccaaa tacgtacatc tgcatgcaaa ggactgtgta a               651


<210>  40
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Thr Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Arg Thr Val 
    210                 215     


<210>  41
<211>  723
<212>  DNA
<213>  Homo sapiens

<400>  41
atgagtaaac aaagaggaac cttctcagaa gtgagtctgg cccaggaccc aaagtggcag       60

caaaggaaac ctaaaggcaa taaaagctcc atttcaggaa ccgaacagga aatattccaa      120

gtagaattaa accttcaaaa tgcttctctg aatcatcaag ggattgataa aatatatgac      180

tgccaaggtt tactgccacc tccagaaaag ctcactgccg aggtcctagg aatcatttgc      240

attgtcctga tggccactgt gttaaaaaca atagttctta ttcctttcct ggagcagaac      300

aattcttccc cgaatgcaag aacccagaaa gcacgtcatt gtggccattg tcctgaggag      360

tggattacat attccaacag ttgttattac attggtaagg aaagaagaac ttgggaagag      420

agtttgcagg cctgtgcttc aaagaactct tctagtctgc tttgtataga taatgaagaa      480

gaaatgaaat ttctggccag cattttacct tcctcatgga ttggtgtgtt tcgtaacagc      540

agtcatcatc catgggtgac aataaatggt ttggctttca aacatgagat aaaagactca      600

gatcatgctg aacgtaactg tgcaatgcta catgtacgtg gacttatatc agaccagtgt      660

ggatcttcaa gaatcattag acggggtttc atcatgttga ccaggctggt cttgaactcc      720

tga                                                                    723


<210>  42
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ser Lys Gln Arg Gly Thr Phe Ser Glu Val Ser Leu Ala Gln Asp 
1               5                   10                  15      


Pro Lys Trp Gln Gln Arg Lys Pro Lys Gly Asn Lys Ser Ser Ile Ser 
            20                  25                  30          


Gly Thr Glu Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Ala 
        35                  40                  45              


Ser Leu Asn His Gln Gly Ile Asp Lys Ile Tyr Asp Cys Gln Gly Leu 
    50                  55                  60                  


Leu Pro Pro Pro Glu Lys Leu Thr Ala Glu Val Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Ile Val Leu Met Ala Thr Val Leu Lys Thr Ile Val Leu Ile Pro Phe 
                85                  90                  95      


Leu Glu Gln Asn Asn Ser Ser Pro Asn Ala Arg Thr Gln Lys Ala Arg 
            100                 105                 110         


His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser Asn Ser Cys 
        115                 120                 125             


Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser Leu Gln Ala 
    130                 135                 140                 


Cys Ala Ser Lys Asn Ser Ser Ser Leu Leu Cys Ile Asp Asn Glu Glu 
145                 150                 155                 160 


Glu Met Lys Phe Leu Ala Ser Ile Leu Pro Ser Ser Trp Ile Gly Val 
                165                 170                 175     


Phe Arg Asn Ser Ser His His Pro Trp Val Thr Ile Asn Gly Leu Ala 
            180                 185                 190         


Phe Lys His Glu Ile Lys Asp Ser Asp His Ala Glu Arg Asn Cys Ala 
        195                 200                 205             


Met Leu His Val Arg Gly Leu Ile Ser Asp Gln Cys Gly Ser Ser Arg 
    210                 215                 220                 


Ile Ile Arg Arg Gly Phe Ile Met Leu Thr Arg Leu Val Leu Asn Ser 
225                 230                 235                 240 


<210>  43
<211>  477
<212>  DNA
<213>  Homo sapiens

<400>  43
atgaataaac aaagaggaac ctactcagaa gtgagtctgg cccaggaccc aaagaggcag       60

caaaggaaac ttaagggcaa taaaatctcc atttcaggaa ccaaacagga aatattccaa      120

gtagaattaa accttcaaaa tgcttcttcg gatcatcaag ggaatgacaa gacatatcac      180

tgcaaaggtt tactgccacc tccagagaag ctcactgctg aggtcctagg aatcatttgc      240

attgtcctga tggccactgt gttaaaaaca atagttctta ttccttgtat tggagtactg      300

gagcagaaca atttttccct gaatagaaga atgcagaaag cacgtcattg tggccattgt      360

cctgaggagt ggattacata ttccaacagt tgttattaca ttggtaagga aagaagaact      420

tgggaagaaa gagtttgctg gcctgtgctt cgaagaactc tgatctgctt tctatag         477


<210>  44
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Asn Lys Gln Arg Gly Thr Tyr Ser Glu Val Ser Leu Ala Gln Asp 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Leu Lys Gly Asn Lys Ile Ser Ile Ser 
            20                  25                  30          


Gly Thr Lys Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Ala 
        35                  40                  45              


Ser Ser Asp His Gln Gly Asn Asp Lys Thr Tyr His Cys Lys Gly Leu 
    50                  55                  60                  


Leu Pro Pro Pro Glu Lys Leu Thr Ala Glu Val Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Ile Val Leu Met Ala Thr Val Leu Lys Thr Ile Val Leu Ile Pro Cys 
                85                  90                  95      


Ile Gly Val Leu Glu Gln Asn Asn Phe Ser Leu Asn Arg Arg Met Gln 
            100                 105                 110         


Lys Ala Arg His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser 
        115                 120                 125             


Asn Ser Cys Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Arg 
    130                 135                 140                 


Val Cys Trp Pro Val Leu Arg Arg Thr Leu Ile Cys Phe Leu 
145                 150                 155             


<210>  45
<211>  774
<212>  DNA
<213>  Homo sapiens

<400>  45
atgagtaaac aaagaggaac cttctcagaa gtgagtctgg cccaggaccc aaagtggcag       60

caaaggaaac ctaaaggcaa taaaagctcc atttcaggaa ccgaacagga aatattccaa      120

gtagaattaa accttcaaaa tgcttctctg aatcatcaag ggattgataa aatatatgac      180

tgccaaggtt tactgccacc tccagaaaag ctcactgccg aggtcctagg aatcatttgc      240

attgtcctga tggccactgt gttaaaaaca atagttctta ttcctttcct ggagcagaac      300

aattcttccc cgaatgcaag aacccagaaa gcacgtcatt gtggccattg tcctgaggag      360

tggattacat attccaacag ttgttattac attggtaagg aaagaagaac ttgggaagag      420

agtttgcagg cctgtgcttc aaagaactct tctagtctgc tttgtataga taatgaagaa      480

gaaatgaaat ttctggccag cattttacct tcctcatgga ttggtgtgtt tcgtaacagc      540

agtcatcatc catgggtgac aataaatggt ttggctttca aacatgagat aaaagactca      600

gatcatgctg aacgtaactg tgcaatgcta catgtacgtg gacttatatc agaccagtgt      660

ggatcttcaa gaatcattgt gagcataagc tttagaatta aagcgcttga gcttgcagtg      720

catcagataa aattttatat ttgttcaaac agaaatgata ttatgattgc ataa            774


<210>  46
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ser Lys Gln Arg Gly Thr Phe Ser Glu Val Ser Leu Ala Gln Asp 
1               5                   10                  15      


Pro Lys Trp Gln Gln Arg Lys Pro Lys Gly Asn Lys Ser Ser Ile Ser 
            20                  25                  30          


Gly Thr Glu Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Ala 
        35                  40                  45              


Ser Leu Asn His Gln Gly Ile Asp Lys Ile Tyr Asp Cys Gln Gly Leu 
    50                  55                  60                  


Leu Pro Pro Pro Glu Lys Leu Thr Ala Glu Val Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Ile Val Leu Met Ala Thr Val Leu Lys Thr Ile Val Leu Ile Pro Phe 
                85                  90                  95      


Leu Glu Gln Asn Asn Ser Ser Pro Asn Ala Arg Thr Gln Lys Ala Arg 
            100                 105                 110         


His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser Asn Ser Cys 
        115                 120                 125             


Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser Leu Gln Ala 
    130                 135                 140                 


Cys Ala Ser Lys Asn Ser Ser Ser Leu Leu Cys Ile Asp Asn Glu Glu 
145                 150                 155                 160 


Glu Met Lys Phe Leu Ala Ser Ile Leu Pro Ser Ser Trp Ile Gly Val 
                165                 170                 175     


Phe Arg Asn Ser Ser His His Pro Trp Val Thr Ile Asn Gly Leu Ala 
            180                 185                 190         


Phe Lys His Glu Ile Lys Asp Ser Asp His Ala Glu Arg Asn Cys Ala 
        195                 200                 205             


Met Leu His Val Arg Gly Leu Ile Ser Asp Gln Cys Gly Ser Ser Arg 
    210                 215                 220                 


Ile Ile Val Ser Ile Ser Phe Arg Ile Lys Ala Leu Glu Leu Ala Val 
225                 230                 235                 240 


His Gln Ile Lys Phe Tyr Ile Cys Ser Asn Arg Asn Asp Ile Met Ile 
                245                 250                 255     


Ala 
    

