                         SEQUENCE LISTING

<110>  Immunorizon Ltd.
       ZHOU, Hongxing
 
<120>  PRECURSOR TRI-SPECIFIC ANTIBODY CONSTRUCTS AND METHODS OF USE 
       THEREOF

<130>  P-586968-PC

<150>	62/844,303
<151>	2019-05-07

<160>  177   

<170>  PatentIn version 3.5

<210>  1
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  2
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro 
            20                  25                  30          


Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp 
        35                  40                  45              


Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys 
    50                  55                  60                  


Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg 
65                  70                  75                  80  


Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg 
                85                  90                  95      


Val Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile 
            100                 105                 110         


Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr 
        115                 120                 125             


Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly 
    130                 135                 140                 


Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro 
145                 150                 155                 160 


Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp 
                165                 170                 175     


Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
            180                 185     


<210>  3
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  extracellular CD3 epsilon

<400>  3

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp 
        115                 120                 125     


<210>  4
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  extracellular CD3 epsilon mature

<400>  4

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro 
            20                  25                  30          


Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp 
        35                  40                  45              


Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys 
    50                  55                  60                  


Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg 
65                  70                  75                  80  


Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg 
                85                  90                  95      


Val Cys Glu Asn Cys Met Glu Met Asp 
            100                 105 


<210>  5
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAP

<400>  5

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
            20                  25          


<210>  6
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
1               5                   10                  15      


Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe 
            20                  25                  30          


Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
        35                  40                  45              


Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
    50                  55                  60                  


Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
65                  70                  75                  80  


Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
                85                  90                  95      


Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
            100                 105                 110         


Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
        115                 120                 125             


Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
    130                 135                 140                 


Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
145                 150                 155                 160 


Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
                165                 170                 175     


Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
            180                 185                 190         


Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
        195                 200                 205             


Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
    210                 215                 220                 


Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
225                 230                 235                 240 


Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
                245                 250                 255     


Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
            260                 265                 270         


Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
        275                 280                 285             


Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
    290                 295                 300                 


Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
305                 310                 315                 320 


Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
                325                 330                 335     


Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
            340                 345                 350         


Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
        355                 360                 365             


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
    370                 375                 380                 


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
385                 390                 395                 400 


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
                405                 410                 415     


Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
            420                 425                 430         


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
        435                 440                 445             


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
    450                 455                 460                 


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
465                 470                 475                 480 


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
                485                 490                 495     


Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
            500                 505                 510         


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
        515                 520                 525             


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
    530                 535                 540                 


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
545                 550                 555                 560 


Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
                565                 570                 575     


Ala Ala 
        


<210>  7
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
1               5                   10                  15      


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 
            20                  25                  30          


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
        35                  40                  45              


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
    50                  55                  60                  


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
65                  70                  75                  80  


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
                85                  90                  95      


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
            100                 105                 110         


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
        115                 120                 125             


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
    130                 135                 140                 


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
145                 150                 155                 160 


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
                165                 170                 175     


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
            180                 185                 190         


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
        195                 200                 205             


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
    210                 215                 220                 


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
225                 230                 235                 240 


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
                245                 250                 255     


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
            260                 265                 270         


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
        275                 280                 285             


Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 
    290                 295                 300                 


Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 
305                 310                 315                 320 


Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 
                325                 330                 335     


Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 
            340                 345                 350         


Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 
        355                 360                 365             


Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 
    370                 375                 380                 


Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 
385                 390                 395                 400 


Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 
                405                 410                 415     


Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 
            420                 425                 430         


Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 
        435                 440                 445             


Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 
    450                 455                 460                 


Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 
465                 470                 475                 480 


Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 
                485                 490                 495     


Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 
            500                 505                 510         


Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 
        515                 520                 525             


Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 
    530                 535                 540                 


Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 
545                 550                 555                 560 


Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 
                565                 570                 575     


Ala 
    


<210>  8
<211>  1731
<212>  DNA
<213>  Homo sapiens

<400>  8
gaggtggccc acaggttcaa ggatctgggc gaggagaact tcaaggccct ggtgctgatc       60

gccttcgccc agtatctgca gcagtgcccc tttgaggacc acgtgaagct ggtgaacgag      120

gtgaccgagt tcgccaagac atgcgtggcc gacgagtccg ccgagaattg tgataagtct      180

ctgcacaccc tgtttggcga taagctgtgc accgtggcca cactgaggga gacatacggc      240

gagatggccg actgctgtgc caagcaggag cccgagcgca acgagtgctt cctgcagcac      300

aaggacgata accctaatct gccacggctg gtgagacctg aggtggacgt gatgtgcacc      360

gccttccacg ataatgagga gacatttctg aagaagtacc tgtatgagat cgcccggaga      420

cacccttact tttatgcccc agagctgctg ttctttgcca agcggtacaa ggcagccttc      480

accgagtgct gtcaggcagc agataaggca gcatgcctgc tgccaaagct ggacgagctg      540

agggatgagg gcaaggcaag ctccgccaag cagcgcctga agtgtgcaag cctgcagaag      600

ttcggagaga gggcctttaa ggcatgggca gtggcaaggc tgtcccagcg gttcccaaag      660

gccgagtttg ccgaggtgtc taagctggtg accgacctga caaaggtgca caccgagtgc      720

tgtcacggcg acctgctgga gtgcgcagac gatagagccg atctggccaa gtacatctgt      780

gagaaccagg actctatctc tagcaagctg aaggagtgct gtgagaagcc cctgctggag      840

aagtcccact gcatcgccga ggtggagaac gacgagatgc cagcagatct gccaagcctg      900

gcagcagact tcgtggagtc caaggacgtg tgcaagaatt acgccgaggc caaggacgtg      960

ttcctgggca tgtttctgta cgagtatgcc aggcgccacc ctgactactc cgtggtgctg     1020

ctgctgcggc tggccaagac ctatgagacc acactggaga agtgctgtgc cgccgccgac     1080

ccccacgagt gctatgcaaa ggtgttcgac gagtttaagc ccctggtgga ggagcctcag     1140

aacctgatca agcagaattg tgagctgttt gagcagctgg gcgagtacaa gttccagaac     1200

gccctgctgg tgagatatac caagaaggtg ccacaggtgt ctacccccac actggtggag     1260

gtgagccgga atctgggcaa ggtcggctcc aagtgctgta agcaccctga ggccaagaga     1320

atgccatgcg ccgaggatta cctgtccgtg gtgctgaacc agctgtgcgt gctgcacgag     1380

aagacccccg tgagcgacag ggtgaccaag tgctgtacag agtctctggt gaaccggaga     1440

ccatgcttta gcgccctgga ggtggatgag acatatgtgc ccaaggagtt caatgccgag     1500

accttcacat ttcacgccga catctgtacc ctgagcgaga aggagcgcca gatcaagaag     1560

cagacagccc tggtggagct ggtgaagcac aagccaaagg ccaccaagga gcagctgaag     1620

gccgtgatgg acgatttcgc cgcctttgtg gagaagtgct gtaaggccga cgataaggag     1680

acatgcttcg cagaggaggg caagaagctg gtggcagcaa gccaggcagc a              1731


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MPP cleavable

<400>  9

Pro Leu Gly Leu Ala Gly 
1               5       


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  10

Gly Pro Leu Gly Met Leu Ser Gln 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  11

Gly Pro Leu Gly Leu Trp Ala Gln 
1               5               


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  12

Gly Pro Leu Gly Leu Ala Gly 
1               5           


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  13

Lys Lys Asn Pro Ala Glu Leu Ile Gly Pro Val Asp 
1               5                   10          


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  14

Lys Lys Gln Pro Ala Ala Asn Leu Val Ala Pro Glu Asp 
1               5                   10              


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  15

Gly Pro Leu Gly Ile Ala Gly Gln 
1               5               


<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  16

Pro Val Gly Leu Ile Gly 
1               5       


<210>  17
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  17

Asn Ser Gly Arg Ala Val 
1               5       


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  18

Ser Gly Arg Ser Ala 
1               5   


<210>  19
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  19

Leu Gly Gly Ser Gly Arg Ser Ala Asn Ala Ile Leu Glu 
1               5                   10              


<210>  20
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  20

Ser Gly Arg Ser 
1               


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  21

Gly Gly Ser Gly Arg Ser Ala Asn Lys 
1               5                   


<210>  22
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  22

Leu Gly Gly Ser Gly Arg Ser Ala Asn Ala Ile Leu Glu Cys 
1               5                   10                  


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  23

Gly Gly Gly Arg Arg 
1               5   


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  24

Thr Gly Arg Gly Pro Ser 
1               5       


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  25

Leu Ser Gly Arg Ser Asp Asn His 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  26

Pro Leu Thr Gly Arg Ser Gly Gly 
1               5               


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  27

Gln Arg Arg Val Val Gly Gly 
1               5           

<210>  28
<211>  1124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC EGFR Polypeptide with multiple cleavage protease sequence

<400>  28

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Ala His Arg Phe 
        35                  40                  45              


Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe 
    50                  55                  60                  


Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val 
65                  70                  75                  80  


Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala 
                85                  90                  95      


Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys 
            100                 105                 110         


Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys 
        115                 120                 125             


Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp 
    130                 135                 140                 


Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met 
145                 150                 155                 160 


Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu 
                165                 170                 175     


Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu 
            180                 185                 190         


Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala 
        195                 200                 205             


Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp 
    210                 215                 220                 


Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu 
225                 230                 235                 240 


Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu 
                245                 250                 255     


Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val 
            260                 265                 270         


Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu 
        275                 280                 285             


Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn 
    290                 295                 300                 


Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu 
305                 310                 315                 320 


Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro 
                325                 330                 335     


Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val 
            340                 345                 350         


Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu 
        355                 360                 365             


Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu 
    370                 375                 380                 


Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala 
385                 390                 395                 400 


Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro 
                405                 410                 415     


Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe 
            420                 425                 430         


Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr 
        435                 440                 445             


Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser 
    450                 455                 460                 


Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala 
465                 470                 475                 480 


Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln 
                485                 490                 495     


Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys 
            500                 505                 510         


Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu 
        515                 520                 525             


Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe 
    530                 535                 540                 


Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile 
545                 550                 555                 560 


Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala 
                565                 570                 575     


Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val 
            580                 585                 590         


Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu 
        595                 600                 605             


Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ser Pro Leu Gly Leu Ala Gly Gly Gly Gly Ser Gly Arg Ser Asp Asn 
625                 630                 635                 640 


His Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                645                 650                 655     


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            660                 665                 670         


Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
        675                 680                 685             


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
    690                 695                 700                 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
705                 710                 715                 720 


Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
                725                 730                 735     


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
            740                 745                 750         


Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Met Val 
        755                 760                 765             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    770                 775                 780                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
785                 790                 795                 800 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                805                 810                 815     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            820                 825                 830         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        835                 840                 845             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    850                 855                 860                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Pro Pro Cys Gly Gly 
865                 870                 875                 880 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
                885                 890                 895     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile 
            900                 905                 910         


Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        915                 920                 925             


Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg 
    930                 935                 940                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
945                 950                 955                 960 


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His 
                965                 970                 975     


Leu Pro Leu Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
            980                 985                 990         


Gly Gly Ser Gly Gly Gly Gly Ser  Gly Gly Gly Gly Ser  Gln Val Gln 
        995                 1000                 1005             


Leu Gln  Glu Ser Gly Pro Gly  Leu Val Lys Pro Ser  Glu Thr Leu 
    1010                 1015                 1020             


Ser Leu  Thr Cys Thr Val Ser  Gly Gly Ser Val Ser  Ser Gly Asp 
    1025                 1030                 1035             


Tyr Tyr  Trp Thr Trp Ile Arg  Gln Ser Pro Gly Lys  Gly Leu Glu 
    1040                 1045                 1050             


Trp Ile  Gly His Ile Tyr Tyr  Ser Gly Asn Thr Asn  Tyr Asn Pro 
    1055                 1060                 1065             


Ser Leu  Lys Ser Arg Leu Thr  Ile Ser Ile Asp Thr  Ser Lys Thr 
    1070                 1075                 1080             


Gln Phe  Ser Leu Lys Leu Ser  Ser Val Thr Ala Ala  Asp Thr Ala 
    1085                 1090                 1095             


Ile Tyr  Tyr Cys Val Arg Asp  Arg Val Thr Gly Ala  Phe Asp Ile 
    1100                 1105                 1110             


Trp Gly  Gln Gly Thr Met Val  Thr Val Ser Ser 
    1115                 1120                 



<210>  29
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  29

Ala Ala Asn Leu 
1               


<210>  30
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  30

Pro Thr Asn Leu 
1               

<210>  31
<211>  1114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC EGFR Polypeptide with MMP2/9 cleavage protease sequence

<400>  31

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Ala His Arg Phe 
        35                  40                  45              


Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe 
    50                  55                  60                  


Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val 
65                  70                  75                  80  


Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala 
                85                  90                  95      


Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys 
            100                 105                 110         


Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys 
        115                 120                 125             


Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp 
    130                 135                 140                 


Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met 
145                 150                 155                 160 


Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu 
                165                 170                 175     


Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu 
            180                 185                 190         


Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala 
        195                 200                 205             


Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp 
    210                 215                 220                 


Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu 
225                 230                 235                 240 


Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu 
                245                 250                 255     


Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val 
            260                 265                 270         


Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu 
        275                 280                 285             


Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn 
    290                 295                 300                 


Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu 
305                 310                 315                 320 


Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro 
                325                 330                 335     


Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val 
            340                 345                 350         


Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu 
        355                 360                 365             


Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu 
    370                 375                 380                 


Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala 
385                 390                 395                 400 


Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro 
                405                 410                 415     


Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe 
            420                 425                 430         


Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr 
        435                 440                 445             


Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser 
    450                 455                 460                 


Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala 
465                 470                 475                 480 


Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln 
                485                 490                 495     


Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys 
            500                 505                 510         


Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu 
        515                 520                 525             


Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe 
    530                 535                 540                 


Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile 
545                 550                 555                 560 


Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala 
                565                 570                 575     


Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val 
            580                 585                 590         


Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu 
        595                 600                 605             


Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ser Pro Leu Gly Leu Ala Gly Gly Gly Ser Gly Gly Ser Glu Val Gln 
625                 630                 635                 640 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                645                 650                 655     


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn 
            660                 665                 670         


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
        675                 680                 685             


Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
    690                 695                 700                 


Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
705                 710                 715                 720 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                725                 730                 735     


Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp 
            740                 745                 750         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        755                 760                 765             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    770                 775                 780                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
785                 790                 795                 800 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                805                 810                 815     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            820                 825                 830         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        835                 840                 845             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    850                 855                 860                 


Cys Pro Pro Cys Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
865                 870                 875                 880 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                885                 890                 895     


Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys 
            900                 905                 910         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu 
        915                 920                 925             


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    930                 935                 940                 


Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe 
945                 950                 955                 960 


Cys Gln His Phe Asp His Leu Pro Leu Ala Phe Gly Gly Gly Thr Lys 
                965                 970                 975     


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            980                 985                 990         


Gly Gly Ser Gln Val Gln Leu Gln  Glu Ser Gly Pro Gly  Leu Val Lys 
        995                 1000                 1005             


Pro Ser  Glu Thr Leu Ser Leu  Thr Cys Thr Val Ser  Gly Gly Ser 
    1010                 1015                 1020             


Val Ser  Ser Gly Asp Tyr Tyr  Trp Thr Trp Ile Arg  Gln Ser Pro 
    1025                 1030                 1035             


Gly Lys  Gly Leu Glu Trp Ile  Gly His Ile Tyr Tyr  Ser Gly Asn 
    1040                 1045                 1050             


Thr Asn  Tyr Asn Pro Ser Leu  Lys Ser Arg Leu Thr  Ile Ser Ile 
    1055                 1060                 1065             


Asp Thr  Ser Lys Thr Gln Phe  Ser Leu Lys Leu Ser  Ser Val Thr 
    1070                 1075                 1080             


Ala Ala  Asp Thr Ala Ile Tyr  Tyr Cys Val Arg Asp  Arg Val Thr 
    1085                 1090                 1095             


Gly Ala  Phe Asp Ile Trp Gly  Gln Gly Thr Met Val  Thr Val Ser 
    1100                 1105                 1110             


Ser 


<210>  32
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC EGFR Polypeptide

<400>  32

Gly Gly Ser Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu 
1               5                   10                  15      


Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr 
            20                  25                  30          


Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro 
        35                  40                  45              


Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro 
    50                  55                  60                  


Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
65                  70                  75                  80  


Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
        115                 120                 125             


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
    130                 135                 140                 


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
145                 150                 155                 160 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
                165                 170                 175     


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
            180                 185                 190         


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
        195                 200                 205             


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Pro Pro Cys Ser 
    210                 215                 220                 


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
225                 230                 235                 240 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp 
                245                 250                 255     


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            260                 265                 270         


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser 
        275                 280                 285             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
    290                 295                 300                 


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp 
305                 310                 315                 320 


His Leu Pro Leu Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly 
                325                 330                 335     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
            340                 345                 350         


Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu 
        355                 360                 365             


Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp Tyr 
    370                 375                 380                 


Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
385                 390                 395                 400 


Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys 
                405                 410                 415     


Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser Leu 
            420                 425                 430         


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Val 
        435                 440                 445             


Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 
    450                 455                 460                 


Val Thr Val Ser Ser 
465                 
 

<210>  33
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  33
ccactgggcc tggccggc                                                     18


<210>  34
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-EGFR VL

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  35
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable

<400>  35

Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn His 
1               5                   10              


<210>  36
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-EGFR VL

<400>  36
gatatccaga tgacccaaag ccccagtagc ctgtccgcca gtgtaggaga tagggtaacc       60

atcacttgcc aagcgagcca agacatcagc aactacctga attggtatca gcagaagccc      120

ggcaaagcac ccaagctcct gatctacgac gccagcaatc tggagaccgg cgtgcccagc      180

aggttcagcg gatctggtag cggcaccgac ttcaccttca ccataagtag tctgcagccc      240

gaggacatcg ccacctactt ctgtcagcac ttcgatcacc tgcccctggc cttcggcggt      300

gggaccaagg tggagatcaa g                                                321


<210>  37
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-EGFR-VH

<400>  37

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  38
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-EGFR-VH

<400>  38
caggtgcagc ttcaagagag cggacccggc ctcgtgaagc ccagcgagac cttgagcctg       60

acctgcactg tgagtggcgg tagcgtgagc agcggcgact attactggac ctggatcagg      120

cagagccctg gcaaggggct ggagtggatc ggccacatct actacagcgg gaacacgaac      180

tacaacccca gcctgaagag caggctgacg atcagcatcg acacgagcaa gacccagttc      240

tcacttaagc tcagcagcgt gaccgccgca gacaccgcca tatactactg cgtgagggac      300

agggtgacgg gcgctttcga catctggggc caaggcacaa tggtcacggt gagctcc         357


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  39

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  40
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker

<400>  40
ggtgggggtg gcagcggggg aggcggaagc ggcggaggtg gctct                       45


<210>  41
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-EGFR VL-linker-VH

<400>  41

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp Tyr Tyr Trp Thr Trp 
145                 150                 155                 160 


Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile Gly His Ile Tyr 
                165                 170                 175     


Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr 
            180                 185                 190         


Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser Leu Lys Leu Ser Ser 
        195                 200                 205             


Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Val Arg Asp Arg Val 
    210                 215                 220                 


Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 
225                 230                 235                 240 


Ser 
    


<210>  42
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-EGFR VH-linker-VL

<400>  42

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln His 
    210                 215                 220                 


Phe Asp His Leu Pro Leu Ala Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  43
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-EGFR VL-linker-VH

<400>  43
gatatccaga tgacccaaag ccccagtagc ctgtccgcca gtgtaggaga tagggtaacc       60

atcacttgcc aagcgagcca agacatcagc aactacctga attggtatca gcagaagccc      120

ggcaaagcac ccaagctcct gatctacgac gccagcaatc tggagaccgg cgtgcccagc      180

aggttcagcg gatctggtag cggcaccgac ttcaccttca ccataagtag tctgcagccc      240

gaggacatcg ccacctactt ctgtcagcac ttcgatcacc tgcccctggc cttcggcggt      300

gggaccaagg tggagatcaa gggtgggggt ggcagcgggg gaggcggaag cggcggaggt      360

ggctcttgcc aggtgcagct tcaagagagc ggacccggcc tcgtgaagcc cagcgagacc      420

ttgagcctga cctgcactgt gagtggcggt agcgtgagca gcggcgacta ttactggacc      480

tggatcaggc agagccctgg caaggggctg gagtggatcg gccacatcta ctacagcggg      540

aacacgaact acaaccccag cctgaagagc aggctgacga tcagcatcga cacgagcaag      600

acccagttct cacttaagct cagcagcgtg accgccgcag acaccgccat atactactgc      660

gtgagggaca gggtgacggg cgctttcgac atctggggcc aaggcacaat ggtcacggtg      720

agctcc                                                                 726


<210>  44
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-EGFR VH-linker-VL

<400>  44
caggtgcagc ttcaagagag cggacccggc ctcgtgaagc ccagcgagac cttgagcctg       60

acctgcactg tgagtggcgg tagcgtgagc agcggcgact attactggac ctggatcagg      120

cagagccctg gcaaggggct ggagtggatc ggccacatct actacagcgg gaacacgaac      180

tacaacccca gcctgaagag caggctgacg atcagcatcg acacgagcaa gacccagttc      240

tcacttaagc tcagcagcgt gaccgccgca gacaccgcca tatactactg cgtgagggac      300

agggtgacgg gcgctttcga catctggggc caaggcacaa tggtcacggt gagctccggt      360

gggggtggca gcgggggagg cggaagcggc ggaggtggct ctgatatcca gatgacccaa      420

agccccagta gcctgtccgc cagtgtagga gatagggtaa ccatcacttg ccaagcgagc      480

caagacatca gcaactacct gaattggtat cagcagaagc ccggcaaagc acccaagctc      540

ctgatctacg acgccagcaa tctggagacc ggcgtgccca gcaggttcag cggatctggt      600

agcggcaccg acttcacctt caccataagt agtctgcagc ccgaggacat cgccacctac      660

ttctgtcagc acttcgatca cctgcccctg gccttcggcg gtgggaccaa ggtggagatc      720

aag                                                                    723


<210>  45
<211>  125
<212>  PRT
<213>  Mus musculus

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 125 


<210>  46
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  47
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  48
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  49
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  50
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  51
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  52
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  53
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  54
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  54

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  55
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  55

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  56
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  57
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  57

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  58
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Arg Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Tyr Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  59
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  59

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Arg Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Tyr Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  60
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  61
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  61

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  62
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Thr Ser Tyr Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  63
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  63

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Thr Ser Tyr Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  64
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gly Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Glu Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Arg Asn Phe Gly Asn Ser Tyr Leu Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  65
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  65

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gly Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Glu Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Arg Asn Phe Gly Asn Ser Tyr Leu Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  66
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  67
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  67

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  68
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  69
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  69

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  70
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  70

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  71
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  72
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH chain

<400>  72

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asp Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  73
<211>  109
<212>  PRT
<213>  Mus musculus

<400>  73

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  74
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain and Constant Light Chain

<400>  74

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu 
    210             


<210>  75
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  75

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val 
            


<210>  76
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  76

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val 
            


<210>  77
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  77

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val 
            


<210>  78
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  78

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val 
            


<210>  79
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  79

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Leu Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val 
            


<210>  80
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  80

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Thr 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  81
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  81

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Trp Thr 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  82
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  82

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  83
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  83

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  84
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  84

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  85
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  85

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  86
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  86

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  87
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  87

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  88
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  88

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  89
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  89

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  90
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  90

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  91
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  91

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  92
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  92

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  93
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  93

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  94
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  94

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  95
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  95

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  96
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  96

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  97
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  97

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  98
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  98

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  99
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  99

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  100
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  100

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  101
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  101

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  102
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  102

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  103
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  103

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Lys Ser Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  104
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1of Heavy Chain (CDR-H1)


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  104

Thr Xaa Xaa Tyr Ala Met Asn 
1               5           


<210>  105
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of Heavy Chain (CDR-H2)

<400>  105

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  106
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of Heavy Chain (CDR-H3)

<400>  106

His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  


<210>  107
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of Light Chain (CDR-L1)

<400>  107

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  108
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of Light Chain (CDR-L1)

<400>  108

Ala Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  109
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of Light Chain (CDR-L1)

<400>  109

Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
1               5                   10                  


<210>  110
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of Light Chain (CDR-L2)

<400>  110

Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210>  111
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of Light Chain (CDR-L3)

<400>  111

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  112
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of Light Chain (CDR-L3)

<400>  112

Leu Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  113
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chainand heavy constant region 1

<400>  113

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220             


<210>  114
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VH

<400>  114

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  115
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Constant Heavy Chain

<400>  115

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  116
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  116

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  117
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Constant Light Chain

<400>  117

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Pro Pro Cys Ser 
            100                 105                 


<210>  118
<211>  1129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC 5T4 Polypeptide with multiple cleavage protease sequence

<400>  4

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Ala His Arg Phe 
        35                  40                  45              


Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe 
    50                  55                  60                  


Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val 
65                  70                  75                  80  


Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala 
                85                  90                  95      


Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys 
            100                 105                 110         


Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys 
        115                 120                 125             


Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp 
    130                 135                 140                 


Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met 
145                 150                 155                 160 


Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu 
                165                 170                 175     


Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu 
            180                 185                 190         


Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala 
        195                 200                 205             


Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp 
    210                 215                 220                 


Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu 
225                 230                 235                 240 


Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu 
                245                 250                 255     


Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val 
            260                 265                 270         


Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu 
        275                 280                 285             


Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn 
    290                 295                 300                 


Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu 
305                 310                 315                 320 


Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro 
                325                 330                 335     


Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val 
            340                 345                 350         


Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu 
        355                 360                 365             


Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu 
    370                 375                 380                 


Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala 
385                 390                 395                 400 


Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro 
                405                 410                 415     


Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe 
            420                 425                 430         


Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr 
        435                 440                 445             


Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser 
    450                 455                 460                 


Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala 
465                 470                 475                 480 


Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln 
                485                 490                 495     


Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys 
            500                 505                 510         


Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu 
        515                 520                 525             


Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe 
    530                 535                 540                 


Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile 
545                 550                 555                 560 


Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala 
                565                 570                 575     


Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val 
            580                 585                 590         


Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu 
        595                 600                 605             


Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ser Pro Leu Gly Leu Ala Gly Gly Gly Gly Ser Gly Arg Ser Asp Asn 
625                 630                 635                 640 


His Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                645                 650                 655     


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            660                 665                 670         


Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
        675                 680                 685             


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
    690                 695                 700                 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
705                 710                 715                 720 


Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
                725                 730                 735     


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
            740                 745                 750         


Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Met Val 
        755                 760                 765             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    770                 775                 780                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
785                 790                 795                 800 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                805                 810                 815     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            820                 825                 830         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        835                 840                 845             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    850                 855                 860                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Pro Pro Cys Gly Gly 
865                 870                 875                 880 


Gly Gly Ser Asp Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
                885                 890                 895     


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
            900                 905                 910         


Ile Ser Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        915                 920                 925             


Lys Ser Leu Ile Tyr Arg Ala Asn Arg Leu Gln Ser Gly Val Pro Ser 
    930                 935                 940                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
945                 950                 955                 960 


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp 
                965                 970                 975     


Asp Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
            980                 985                 990         


Gly Gly Gly Ser Gly Gly Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly 
        995                 1000                 1005             


Gly Gly  Ser Gln Val Gln Leu  Val Gln Ser Gly Ala  Glu Val Lys 
    1010                 1015                 1020             


Lys Pro  Gly Ala Ser Val Lys  Val Ser Cys Lys Ala  Ser Gly Tyr 
    1025                 1030                 1035             


Thr Phe  Thr Ser Phe Trp Met  His Trp Val Arg Gln  Ala Pro Gly 
    1040                 1045                 1050             


Gln Gly  Leu Glu Trp Met Gly  Arg Ile Asp Pro Asn  Arg Gly Gly 
    1055                 1060                 1065             


Thr Glu  Tyr Asn Glu Lys Ala  Lys Ser Arg Val Thr  Met Thr Ala 
    1070                 1075                 1080             


Asp Lys  Ser Thr Ser Thr Ala  Tyr Met Glu Leu Ser  Ser Leu Arg 
    1085                 1090                 1095             


Ser Glu  Asp Thr Ala Val Tyr  Tyr Cys Ala Gly Gly  Asn Pro Tyr 
    1100                 1105                 1110             


Tyr Pro  Met Asp Tyr Trp Gly  Gln Gly Thr Thr Val  Thr Val Ser 
    1115                 1120                 1125             


Ser 
    


<210>  119
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  119

Gly Ser Gly Gly Ser Asn 
1               5       


<210>  120
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  120

Gly Gly Gly Ser Asn 
1               5   


<210>  121
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  121

Gly Gly Ser Gly 
1               


<210>  122
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  122

Gly Gly Ser Gly Gly 
1               5   


<210>  123
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  123

Gly Ser Gly Ser Gly 
1               5   


<210>  124
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  124

Gly Ser Gly Gly Gly 
1               5   


<210>  125
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  125

Gly Gly Gly Ser Gly 
1               5   


<210>  126
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  126

Gly Ser Ser Ser Gly 
1               5   


<210>  127
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  127

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  128
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  128

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  129
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  129

Gly Gly Gly Gly Ser 
1               5   


<210>  130
<211>  1072
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC polypeptide

<400>  130

Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
1               5                   10                  15      


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 
            20                  25                  30          


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
        35                  40                  45              


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
    50                  55                  60                  


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
65                  70                  75                  80  


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
                85                  90                  95      


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
            100                 105                 110         


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
        115                 120                 125             


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
    130                 135                 140                 


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
145                 150                 155                 160 


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
                165                 170                 175     


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
            180                 185                 190         


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
        195                 200                 205             


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
    210                 215                 220                 


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
225                 230                 235                 240 


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
                245                 250                 255     


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
            260                 265                 270         


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
        275                 280                 285             


Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 
    290                 295                 300                 


Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 
305                 310                 315                 320 


Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 
                325                 330                 335     


Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 
            340                 345                 350         


Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 
        355                 360                 365             


Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 
    370                 375                 380                 


Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 
385                 390                 395                 400 


Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 
                405                 410                 415     


Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 
            420                 425                 430         


Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 
        435                 440                 445             


Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 
    450                 455                 460                 


Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 
465                 470                 475                 480 


Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 
                485                 490                 495     


Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 
            500                 505                 510         


Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 
        515                 520                 525             


Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 
    530                 535                 540                 


Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 
545                 550                 555                 560 


Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 
                565                 570                 575     


Ala Gly Gly Ser Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        595                 600                 605             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
    610                 615                 620                 


Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
625                 630                 635                 640 


Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 
                645                 650                 655     


Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
            660                 665                 670         


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
        675                 680                 685             


Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val 
    690                 695                 700                 


Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
705                 710                 715                 720 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
                725                 730                 735     


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            740                 745                 750         


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        755                 760                 765             


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    770                 775                 780                 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
785                 790                 795                 800 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                805                 810                 815     


Arg Val Glu Pro Lys Ser Cys Pro Pro Cys Gly Gly Gly Gly Ser Asp 
            820                 825                 830         


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
        835                 840                 845             


Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu 
    850                 855                 860                 


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
865                 870                 875                 880 


Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
                885                 890                 895     


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
            900                 905                 910         


Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu Ala 
        915                 920                 925             


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
    930                 935                 940                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser 
945                 950                 955                 960 


Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr 
                965                 970                 975     


Val Ser Gly Gly Ser Val Ser Ser Gly Asp Tyr Tyr Trp Thr Trp Ile 
            980                 985                 990         


Arg Gln Ser Pro Gly Lys Gly Leu  Glu Trp Ile Gly His  Ile Tyr Tyr 
        995                 1000                 1005             


Ser Gly  Asn Thr Asn Tyr Asn  Pro Ser Leu Lys Ser  Arg Leu Thr 
    1010                 1015                 1020             


Ile Ser  Ile Asp Thr Ser Lys  Thr Gln Phe Ser Leu  Lys Leu Ser 
    1025                 1030                 1035             


Ser Val  Thr Ala Ala Asp Thr  Ala Ile Tyr Tyr Cys  Val Arg Asp 
    1040                 1045                 1050             


Arg Val  Thr Gly Ala Phe Asp  Ile Trp Gly Gln Gly  Thr Met Val 
    1055                 1060                 1065             


Thr Val  Ser Ser 
    1070         


<210>  131
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC polypeptide

<400>  131

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser Pro Leu Gly Leu Ala Gly Gly Gly Ser Gly Gly Ser Gln Ala Val 
        35                  40                  45              


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
    50                  55                  60                  


Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala 
65                  70                  75                  80  


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
                85                  90                  95      


Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
            100                 105                 110         


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
        115                 120                 125             


Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val 
    130                 135                 140                 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
145                 150                 155                 160 


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
                165                 170                 175     


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
            180                 185                 190         


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
        195                 200                 205             


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
    210                 215                 220                 


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
225                 230                 235                 240 


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
                245                 250                 255     


Thr Glu Cys Pro Pro Cys Ser Gly Gly Gly Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu Ala Phe Gly Gly Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
385                 390                 395                 400 


Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly 
                405                 410                 415     


Ser Val Ser Ser Gly Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro 
            420                 425                 430         


Gly Lys Gly Leu Glu Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr 
        435                 440                 445             


Asn Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr 
    450                 455                 460                 


Ser Lys Thr Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
465                 470                 475                 480 


Thr Ala Ile Tyr Tyr Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp 
                485                 490                 495     


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
            500                 505             


<210>  132
<211>  1072
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC polypeptide

<400>  132

Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
1               5                   10                  15      


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 
            20                  25                  30          


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
        35                  40                  45              


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
    50                  55                  60                  


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
65                  70                  75                  80  


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
                85                  90                  95      


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
            100                 105                 110         


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
        115                 120                 125             


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
    130                 135                 140                 


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
145                 150                 155                 160 


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
                165                 170                 175     


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
            180                 185                 190         


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
        195                 200                 205             


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
    210                 215                 220                 


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
225                 230                 235                 240 


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
                245                 250                 255     


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
            260                 265                 270         


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
        275                 280                 285             


Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 
    290                 295                 300                 


Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 
305                 310                 315                 320 


Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 
                325                 330                 335     


Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 
            340                 345                 350         


Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 
        355                 360                 365             


Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 
    370                 375                 380                 


Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 
385                 390                 395                 400 


Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 
                405                 410                 415     


Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 
            420                 425                 430         


Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 
        435                 440                 445             


Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 
    450                 455                 460                 


Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 
465                 470                 475                 480 


Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 
                485                 490                 495     


Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 
            500                 505                 510         


Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 
        515                 520                 525             


Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 
    530                 535                 540                 


Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 
545                 550                 555                 560 


Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 
                565                 570                 575     


Ala Gly Gly Ser Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        595                 600                 605             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
    610                 615                 620                 


Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
625                 630                 635                 640 


Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 
                645                 650                 655     


Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
            660                 665                 670         


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
        675                 680                 685             


Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val 
    690                 695                 700                 


Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
705                 710                 715                 720 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
                725                 730                 735     


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            740                 745                 750         


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        755                 760                 765             


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    770                 775                 780                 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
785                 790                 795                 800 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                805                 810                 815     


Arg Val Glu Pro Lys Ser Cys Pro Pro Cys Gly Gly Gly Gly Ser Gln 
            820                 825                 830         


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
        835                 840                 845             


Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp 
    850                 855                 860                 


Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
865                 870                 875                 880 


Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu 
                885                 890                 895     


Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser 
            900                 905                 910         


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys 
        915                 920                 925             


Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr 
    930                 935                 940                 


Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
945                 950                 955                 960 


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
                965                 970                 975     


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln 
            980                 985                 990         


Asp Ile Ser Asn Tyr Leu Asn Trp  Tyr Gln Gln Lys Pro  Gly Lys Ala 
        995                 1000                 1005             


Pro Lys  Leu Leu Ile Tyr Asp  Ala Ser Asn Leu Glu  Thr Gly Val 
    1010                 1015                 1020             


Pro Ser  Arg Phe Ser Gly Ser  Gly Ser Gly Thr Asp  Phe Thr Phe 
    1025                 1030                 1035             


Thr Ile  Ser Ser Leu Gln Pro  Glu Asp Ile Ala Thr  Tyr Phe Cys 
    1040                 1045                 1050             


Gln His  Phe Asp His Leu Pro  Leu Ala Phe Gly Gly  Gly Thr Lys 
    1055                 1060                 1065             


Val Glu  Ile Lys 
    1070         


<210>  133
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC polypeptide

<400>  133

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser Pro Leu Gly Leu Ala Gly Gly Gly Ser Gly Gly Ser Gln Ala Val 
        35                  40                  45              


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
    50                  55                  60                  


Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala 
65                  70                  75                  80  


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
                85                  90                  95      


Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
            100                 105                 110         


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
        115                 120                 125             


Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val 
    130                 135                 140                 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
145                 150                 155                 160 


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
                165                 170                 175     


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
            180                 185                 190         


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
        195                 200                 205             


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
    210                 215                 220                 


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
225                 230                 235                 240 


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
                245                 250                 255     


Thr Glu Cys Pro Pro Cys Ser Gly Gly Gly Ser Gln Val Gln Leu Gln 
            260                 265                 270         


Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr 
        275                 280                 285             


Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp Tyr Tyr Trp Thr 
    290                 295                 300                 


Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile Gly His Ile 
305                 310                 315                 320 


Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Leu 
                325                 330                 335     


Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser Leu Lys Leu Ser 
            340                 345                 350         


Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Val Arg Asp Arg 
        355                 360                 365             


Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
                405                 410                 415     


Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn 
            420                 425                 430         


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        435                 440                 445             


Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser 
    450                 455                 460                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln 
465                 470                 475                 480 


Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro 
                485                 490                 495     


Leu Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            500                 505             


<210>  134
<211>  1072
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC polypeptide

<400>  134

Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
1               5                   10                  15      


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 
            20                  25                  30          


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
        35                  40                  45              


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
    50                  55                  60                  


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
65                  70                  75                  80  


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
                85                  90                  95      


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
            100                 105                 110         


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
        115                 120                 125             


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
    130                 135                 140                 


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
145                 150                 155                 160 


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
                165                 170                 175     


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
            180                 185                 190         


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
        195                 200                 205             


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
    210                 215                 220                 


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
225                 230                 235                 240 


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
                245                 250                 255     


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
            260                 265                 270         


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
        275                 280                 285             


Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 
    290                 295                 300                 


Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 
305                 310                 315                 320 


Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 
                325                 330                 335     


Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 
            340                 345                 350         


Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 
        355                 360                 365             


Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 
    370                 375                 380                 


Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 
385                 390                 395                 400 


Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 
                405                 410                 415     


Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 
            420                 425                 430         


Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 
        435                 440                 445             


Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 
    450                 455                 460                 


Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 
465                 470                 475                 480 


Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 
                485                 490                 495     


Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 
            500                 505                 510         


Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 
        515                 520                 525             


Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 
    530                 535                 540                 


Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 
545                 550                 555                 560 


Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 
                565                 570                 575     


Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            580                 585                 590         


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        595                 600                 605             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
    610                 615                 620                 


Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
625                 630                 635                 640 


Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 
                645                 650                 655     


Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
            660                 665                 670         


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
        675                 680                 685             


Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val 
    690                 695                 700                 


Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
705                 710                 715                 720 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
                725                 730                 735     


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            740                 745                 750         


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        755                 760                 765             


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    770                 775                 780                 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
785                 790                 795                 800 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                805                 810                 815     


Arg Val Glu Pro Lys Ser Cys Pro Pro Cys Gly Gly Gly Gly Ser Asp 
            820                 825                 830         


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
        835                 840                 845             


Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu 
    850                 855                 860                 


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
865                 870                 875                 880 


Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
                885                 890                 895     


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
            900                 905                 910         


Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu Ala 
        915                 920                 925             


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
    930                 935                 940                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser 
945                 950                 955                 960 


Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr 
                965                 970                 975     


Val Ser Gly Gly Ser Val Ser Ser Gly Asp Tyr Tyr Trp Thr Trp Ile 
            980                 985                 990         


Arg Gln Ser Pro Gly Lys Gly Leu  Glu Trp Ile Gly His  Ile Tyr Tyr 
        995                 1000                 1005             


Ser Gly  Asn Thr Asn Tyr Asn  Pro Ser Leu Lys Ser  Arg Leu Thr 
    1010                 1015                 1020             


Ile Ser  Ile Asp Thr Ser Lys  Thr Gln Phe Ser Leu  Lys Leu Ser 
    1025                 1030                 1035             


Ser Val  Thr Ala Ala Asp Thr  Ala Ile Tyr Tyr Cys  Val Arg Asp 
    1040                 1045                 1050             


Arg Val  Thr Gly Ala Phe Asp  Ile Trp Gly Gln Gly  Thr Met Val 
    1055                 1060                 1065             


Thr Val  Ser Ser 
    1070         


<210>  135
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC polypeptide

<400>  135

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gln Ala Val 
        35                  40                  45              


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
    50                  55                  60                  


Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala 
65                  70                  75                  80  


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
                85                  90                  95      


Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
            100                 105                 110         


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
        115                 120                 125             


Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val 
    130                 135                 140                 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
145                 150                 155                 160 


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
                165                 170                 175     


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
            180                 185                 190         


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
        195                 200                 205             


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
    210                 215                 220                 


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
225                 230                 235                 240 


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
                245                 250                 255     


Thr Glu Cys Pro Pro Cys Ser Gly Gly Gly Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu Ala Phe Gly Gly Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
385                 390                 395                 400 


Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly 
                405                 410                 415     


Ser Val Ser Ser Gly Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro 
            420                 425                 430         


Gly Lys Gly Leu Glu Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr 
        435                 440                 445             


Asn Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr 
    450                 455                 460                 


Ser Lys Thr Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
465                 470                 475                 480 


Thr Ala Ile Tyr Tyr Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp 
                485                 490                 495     


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
            500                 505             


<210>  136
<211>  1072
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC polypeptide

<400>  136

Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
1               5                   10                  15      


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 
            20                  25                  30          


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
        35                  40                  45              


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
    50                  55                  60                  


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
65                  70                  75                  80  


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
                85                  90                  95      


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
            100                 105                 110         


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
        115                 120                 125             


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
    130                 135                 140                 


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
145                 150                 155                 160 


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
                165                 170                 175     


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
            180                 185                 190         


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
        195                 200                 205             


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
    210                 215                 220                 


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
225                 230                 235                 240 


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
                245                 250                 255     


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
            260                 265                 270         


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
        275                 280                 285             


Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 
    290                 295                 300                 


Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 
305                 310                 315                 320 


Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 
                325                 330                 335     


Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 
            340                 345                 350         


Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 
        355                 360                 365             


Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 
    370                 375                 380                 


Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 
385                 390                 395                 400 


Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 
                405                 410                 415     


Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 
            420                 425                 430         


Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 
        435                 440                 445             


Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 
    450                 455                 460                 


Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 
465                 470                 475                 480 


Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 
                485                 490                 495     


Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 
            500                 505                 510         


Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 
        515                 520                 525             


Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 
    530                 535                 540                 


Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 
545                 550                 555                 560 


Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 
                565                 570                 575     


Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            580                 585                 590         


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        595                 600                 605             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
    610                 615                 620                 


Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
625                 630                 635                 640 


Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 
                645                 650                 655     


Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
            660                 665                 670         


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
        675                 680                 685             


Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val 
    690                 695                 700                 


Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
705                 710                 715                 720 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
                725                 730                 735     


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            740                 745                 750         


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        755                 760                 765             


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    770                 775                 780                 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
785                 790                 795                 800 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                805                 810                 815     


Arg Val Glu Pro Lys Ser Cys Pro Pro Cys Gly Gly Gly Gly Ser Gln 
            820                 825                 830         


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
        835                 840                 845             


Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp 
    850                 855                 860                 


Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
865                 870                 875                 880 


Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu 
                885                 890                 895     


Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser 
            900                 905                 910         


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys 
        915                 920                 925             


Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr 
    930                 935                 940                 


Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
945                 950                 955                 960 


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
                965                 970                 975     


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln 
            980                 985                 990         


Asp Ile Ser Asn Tyr Leu Asn Trp  Tyr Gln Gln Lys Pro  Gly Lys Ala 
        995                 1000                 1005             


Pro Lys  Leu Leu Ile Tyr Asp  Ala Ser Asn Leu Glu  Thr Gly Val 
    1010                 1015                 1020             


Pro Ser  Arg Phe Ser Gly Ser  Gly Ser Gly Thr Asp  Phe Thr Phe 
    1025                 1030                 1035             


Thr Ile  Ser Ser Leu Gln Pro  Glu Asp Ile Ala Thr  Tyr Phe Cys 
    1040                 1045                 1050             


Gln His  Phe Asp His Leu Pro  Leu Ala Phe Gly Gly  Gly Thr Lys 
    1055                 1060                 1065             


Val Glu  Ile Lys 
    1070         


<210>  137
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC polypeptide

<400>  137

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gln Ala Val 
        35                  40                  45              


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
    50                  55                  60                  


Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala 
65                  70                  75                  80  


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
                85                  90                  95      


Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
            100                 105                 110         


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
        115                 120                 125             


Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val 
    130                 135                 140                 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
145                 150                 155                 160 


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
                165                 170                 175     


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
            180                 185                 190         


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
        195                 200                 205             


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
    210                 215                 220                 


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
225                 230                 235                 240 


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
                245                 250                 255     


Thr Glu Cys Pro Pro Cys Ser Gly Gly Gly Ser Gln Val Gln Leu Gln 
            260                 265                 270         


Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr 
        275                 280                 285             


Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp Tyr Tyr Trp Thr 
    290                 295                 300                 


Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile Gly His Ile 
305                 310                 315                 320 


Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Leu 
                325                 330                 335     


Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser Leu Lys Leu Ser 
            340                 345                 350         


Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Val Arg Asp Arg 
        355                 360                 365             


Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
                405                 410                 415     


Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn 
            420                 425                 430         


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        435                 440                 445             


Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser 
    450                 455                 460                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln 
465                 470                 475                 480 


Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro 
                485                 490                 495     


Leu Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            500                 505             


<210>  138
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC polypeptide

<400>  138

Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
1               5                   10                  15      


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25                  30          


Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
        35                  40                  45              


Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr 
    50                  55                  60                  


Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
65                  70                  75                  80  


Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
                85                  90                  95      


Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
            100                 105                 110         


Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Met Val Thr 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Pro Pro Cys Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
                245                 250                 255     


Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser 
            260                 265                 270         


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        275                 280                 285             


Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe 
    290                 295                 300                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu 
305                 310                 315                 320 


Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu 
                325                 330                 335     


Pro Leu Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
            340                 345                 350         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
        355                 360                 365             


Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu 
    370                 375                 380                 


Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp Tyr Tyr Trp 
385                 390                 395                 400 


Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile Gly His 
                405                 410                 415     


Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg 
            420                 425                 430         


Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser Leu Lys Leu 
        435                 440                 445             


Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Val Arg Asp 
    450                 455                 460                 


Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr 
465                 470                 475                 480 


Val Ser Ser 
            


<210>  139
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC polypeptide

<400>  139

Gly Gly Ser Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu 
1               5                   10                  15      


Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr 
            20                  25                  30          


Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro 
        35                  40                  45              


Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro 
    50                  55                  60                  


Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
65                  70                  75                  80  


Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
        115                 120                 125             


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
    130                 135                 140                 


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
145                 150                 155                 160 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
                165                 170                 175     


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
            180                 185                 190         


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
        195                 200                 205             


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Pro Pro Cys Ser 
    210                 215                 220                 


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
225                 230                 235                 240 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp 
                245                 250                 255     


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            260                 265                 270         


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser 
        275                 280                 285             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
    290                 295                 300                 


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp 
305                 310                 315                 320 


His Leu Pro Leu Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly 
                325                 330                 335     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
            340                 345                 350         


Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu 
        355                 360                 365             


Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp Tyr 
    370                 375                 380                 


Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
385                 390                 395                 400 


Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys 
                405                 410                 415     


Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser Leu 
            420                 425                 430         


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Val 
        435                 440                 445             


Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 
    450                 455                 460                 


Val Thr Val Ser Ser 
465                 


<210>  140
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC polypeptide

<400>  140

Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
1               5                   10                  15      


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25                  30          


Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
        35                  40                  45              


Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr 
    50                  55                  60                  


Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
65                  70                  75                  80  


Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
                85                  90                  95      


Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
            100                 105                 110         


Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Met Val Thr 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Pro Pro Cys Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
                245                 250                 255     


Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser 
            260                 265                 270         


Ser Gly Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly 
        275                 280                 285             


Leu Glu Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn 
    290                 295                 300                 


Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr 
305                 310                 315                 320 


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile 
                325                 330                 335     


Tyr Tyr Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly 
            340                 345                 350         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    370                 375                 380                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
385                 390                 395                 400 


Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                405                 410                 415     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr 
            420                 425                 430         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        435                 440                 445             


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys 
    450                 455                 460                 


Gln His Phe Asp His Leu Pro Leu Ala Phe Gly Gly Gly Thr Lys Val 
465                 470                 475                 480 


Glu Ile Lys 
            


<210>  141
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC polypeptide

<400>  141

Gly Gly Ser Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu 
1               5                   10                  15      


Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr 
            20                  25                  30          


Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro 
        35                  40                  45              


Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro 
    50                  55                  60                  


Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
65                  70                  75                  80  


Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
        115                 120                 125             


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
    130                 135                 140                 


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
145                 150                 155                 160 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
                165                 170                 175     


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
            180                 185                 190         


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
        195                 200                 205             


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Pro Pro Cys Ser 
    210                 215                 220                 


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
225                 230                 235                 240 


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser 
                245                 250                 255     


Val Ser Ser Gly Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly 
            260                 265                 270         


Lys Gly Leu Glu Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn 
        275                 280                 285             


Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser 
    290                 295                 300                 


Lys Thr Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
305                 310                 315                 320 


Ala Ile Tyr Tyr Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile 
                325                 330                 335     


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
        355                 360                 365             


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
    370                 375                 380                 


Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln 
385                 390                 395                 400 


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu 
                405                 410                 415     


Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
            420                 425                 430         


Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
        435                 440                 445             


Phe Cys Gln His Phe Asp His Leu Pro Leu Ala Phe Gly Gly Gly Thr 
    450                 455                 460                 


Lys Val Glu Ile Lys 
465                 


<210>  142
<211>  3219
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC polypeptide

<400>  142
gaggtggccc acaggttcaa ggatctgggc gaggagaact tcaaggccct ggtgctgatc       60

gccttcgccc agtatctgca gcagtgcccc tttgaggacc acgtgaagct ggtgaacgag      120

gtgaccgagt tcgccaagac atgcgtggcc gacgagtccg ccgagaattg tgataagtct      180

ctgcacaccc tgtttggcga taagctgtgc accgtggcca cactgaggga gacatacggc      240

gagatggccg actgctgtgc caagcaggag cccgagcgca acgagtgctt cctgcagcac      300

aaggacgata accctaatct gccacggctg gtgagacctg aggtggacgt gatgtgcacc      360

gccttccacg ataatgagga gacatttctg aagaagtacc tgtatgagat cgcccggaga      420

cacccttact tttatgcccc agagctgctg ttctttgcca agcggtacaa ggcagccttc      480

accgagtgct gtcaggcagc agataaggca gcatgcctgc tgccaaagct ggacgagctg      540

agggatgagg gcaaggcaag ctccgccaag cagcgcctga agtgtgcaag cctgcagaag      600

ttcggagaga gggcctttaa ggcatgggca gtggcaaggc tgtcccagcg gttcccaaag      660

gccgagtttg ccgaggtgtc taagctggtg accgacctga caaaggtgca caccgagtgc      720

tgtcacggcg acctgctgga gtgcgcagac gatagagccg atctggccaa gtacatctgt      780

gagaaccagg actctatctc tagcaagctg aaggagtgct gtgagaagcc cctgctggag      840

aagtcccact gcatcgccga ggtggagaac gacgagatgc cagcagatct gccaagcctg      900

gcagcagact tcgtggagtc caaggacgtg tgcaagaatt acgccgaggc caaggacgtg      960

ttcctgggca tgtttctgta cgagtatgcc aggcgccacc ctgactactc cgtggtgctg     1020

ctgctgcggc tggccaagac ctatgagacc acactggaga agtgctgtgc cgccgccgac     1080

ccccacgagt gctatgcaaa ggtgttcgac gagtttaagc ccctggtgga ggagcctcag     1140

aacctgatca agcagaattg tgagctgttt gagcagctgg gcgagtacaa gttccagaac     1200

gccctgctgg tgagatatac caagaaggtg ccacaggtgt ctacccccac actggtggag     1260

gtgagccgga atctgggcaa ggtcggctcc aagtgctgta agcaccctga ggccaagaga     1320

atgccatgcg ccgaggatta cctgtccgtg gtgctgaacc agctgtgcgt gctgcacgag     1380

aagacccccg tgagcgacag ggtgaccaag tgctgtacag agtctctggt gaaccggaga     1440

ccatgcttta gcgccctgga ggtggatgag acatatgtgc ccaaggagtt caatgccgag     1500

accttcacat ttcacgccga catctgtacc ctgagcgaga aggagcgcca gatcaagaag     1560

cagacagccc tggtggagct ggtgaagcac aagccaaagg ccaccaagga gcagctgaag     1620

gccgtgatgg acgatttcgc cgcctttgtg gagaagtgct gtaaggccga cgataaggag     1680

acatgcttcg cagaggaggg caagaagctg gtggcagcaa gccaggcagc aggaggctcc     1740

ggcggctctc cactgggcct ggccggcggc ggcagcggcg gctccgaggt gcagctggtg     1800

gagtccggcg gcggcctggt gcagcccggc ggcagcctga ggctgtcctg cgccgcctct     1860

ggcttcacct ttaacacata cgcaatgaat tgggtgcgcc aggcaccagg caagggactg     1920

gagtgggtgg cccggatcag aagcaagtac aacaattatg ccacctacta tgccgactcc     1980

gtgaaggatc ggtttaccat cagcagagac gattccaaga acacactgta tctgcagatg     2040

aatagcctgc gggccgagga tacagccgtg tactattgcg tgagacacgg caactttggc     2100

aattcttacg tgagctggtt cgcctattgg ggccagggca ccatggtgac agtgtcctct     2160

gcctctacca agggacctag cgtgttccca ctggcaccta gctccaagtc taccagcgga     2220

ggcacagccg ccctgggatg tctggtgaag gactactttc cagagcccgt gacagtgtcc     2280

tggaactctg gcgccctgac cagcggagtg cacacattcc ctgccgtgct gcagtctagc     2340

ggcctgtact ccctgtcctc tgtggtgacc gtgccaagct cctctctggg cacccagaca     2400

tatatctgca acgtgaatca caagccctct aatacaaagg tggacaagag ggtggagcct     2460

aagagctgcc ccccttgtgg cggaggcggt agcgatatcc agatgaccca aagccccagt     2520

agcctgtccg ccagtgtagg agatagggta accatcactt gccaagcgag ccaagacatc     2580

agcaactacc tgaattggta tcagcagaag cccggcaaag cacccaagct cctgatctac     2640

gacgccagca atctggagac cggcgtgccc agcaggttca gcggatctgg tagcggcacc     2700

gacttcacct tcaccataag tagtctgcag cccgaggaca tcgccaccta cttctgtcag     2760

cacttcgatc acctgcccct ggccttcggc ggtgggacca aggtggagat caagggtggg     2820

ggtggcagcg ggggaggcgg aagcggcgga ggtggctctt gccaggtgca gcttcaagag     2880

agcggacccg gcctcgtgaa gcccagcgag accttgagcc tgacctgcac tgtgagtggc     2940

ggtagcgtga gcagcggcga ctattactgg acctggatca ggcagagccc tggcaagggg     3000

ctggagtgga tcggccacat ctactacagc gggaacacga actacaaccc cagcctgaag     3060

agcaggctga cgatcagcat cgacacgagc aagacccagt tctcacttaa gctcagcagc     3120

gtgaccgccg cagacaccgc catatactac tgcgtgaggg acagggtgac gggcgctttc     3180

gacatctggg gccaaggcac aatggtcacg gtgagctcc                            3219


<210>  143
<211>  1524
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC polypeptide

<400>  143
caggacggca acgaggagat gggcggcatc acccagacac catacaaggt gagcatctcc       60

ggcaccacag tgatcctgac cggaggctcc ggcggctctc cactgggcct ggccggcggc      120

ggcagcggcg gctcccaagc cgtggtaacc caggagccca gtctgacagt gagccctggc      180

ggtacagtga ccttgacttg caggagcagt accggagccg taactacctc aaactacgcc      240

aactgggtgc agcagaagcc cggtcaggcc cccaggggcc ttattggtgg gactaacaaa      300

cgagcacccg gaacccccgc aaggttcagc ggcagccttc tgggcggaaa ggccgctctc      360

acattgagcg gcgtgcagcc cgaggacgag gccgagtact actgcgccct gtggtacagc      420

aacctgtggg tgttcggcgg agggaccaag ctgaccgtgc tgggccagcc caaagctgcg      480

ccgagcgtga ccctgttccc cccgtcaagc gaggagctgc aggctaacaa ggccaccctg      540

gtgtgcctga ttagtgactt ctaccccggt gccgtcaccg tggcctggaa ggccgacagt      600

agcccagtta aagcgggcgt cgagaccacc actcccagca agcagagcaa caacaagtac      660

gccgcgagca gctacctgag tctgaccccc gagcagtgga agagccacag gagctacagc      720

tgccaggtga cccacgaggg cagcactgtg gagaagactg tggccccgac cgagtgcccc      780

ccatgtagcg gcggagggtc cgatatccag atgacccaaa gccccagtag cctgtccgcc      840

agtgtaggag atagggtaac catcacttgc caagcgagcc aagacatcag caactacctg      900

aattggtatc agcagaagcc cggcaaagca cccaagctcc tgatctacga cgccagcaat      960

ctggagaccg gcgtgcccag caggttcagc ggatctggta gcggcaccga cttcaccttc     1020

accataagta gtctgcagcc cgaggacatc gccacctact tctgtcagca cttcgatcac     1080

ctgcccctgg ccttcggcgg tgggaccaag gtggagatca agggtggggg tggcagcggg     1140

ggaggcggaa gcggcggagg tggctctcag gtgcagcttc aagagagcgg acccggcctc     1200

gtgaagccca gcgagacctt gagcctgacc tgcactgtga gtggcggtag cgtgagcagc     1260

ggcgactatt actggacctg gatcaggcag agccctggca aggggctgga gtggatcggc     1320

cacatctact acagcgggaa cacgaactac aaccccagcc tgaagagcag gctgacgatc     1380

agcatcgaca cgagcaagac ccagttctca cttaagctca gcagcgtgac cgccgcagac     1440

accgccatat actactgcgt gagggacagg gtgacgggcg ctttcgacat ctggggccaa     1500

ggcacaatgg tcacggtgag ctcc                                            1524


<210>  144
<211>  3216
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC polypeptide

<400>  144
gaggtggccc acaggttcaa ggatctgggc gaggagaact tcaaggccct ggtgctgatc       60

gccttcgccc agtatctgca gcagtgcccc tttgaggacc acgtgaagct ggtgaacgag      120

gtgaccgagt tcgccaagac atgcgtggcc gacgagtccg ccgagaattg tgataagtct      180

ctgcacaccc tgtttggcga taagctgtgc accgtggcca cactgaggga gacatacggc      240

gagatggccg actgctgtgc caagcaggag cccgagcgca acgagtgctt cctgcagcac      300

aaggacgata accctaatct gccacggctg gtgagacctg aggtggacgt gatgtgcacc      360

gccttccacg ataatgagga gacatttctg aagaagtacc tgtatgagat cgcccggaga      420

cacccttact tttatgcccc agagctgctg ttctttgcca agcggtacaa ggcagccttc      480

accgagtgct gtcaggcagc agataaggca gcatgcctgc tgccaaagct ggacgagctg      540

agggatgagg gcaaggcaag ctccgccaag cagcgcctga agtgtgcaag cctgcagaag      600

ttcggagaga gggcctttaa ggcatgggca gtggcaaggc tgtcccagcg gttcccaaag      660

gccgagtttg ccgaggtgtc taagctggtg accgacctga caaaggtgca caccgagtgc      720

tgtcacggcg acctgctgga gtgcgcagac gatagagccg atctggccaa gtacatctgt      780

gagaaccagg actctatctc tagcaagctg aaggagtgct gtgagaagcc cctgctggag      840

aagtcccact gcatcgccga ggtggagaac gacgagatgc cagcagatct gccaagcctg      900

gcagcagact tcgtggagtc caaggacgtg tgcaagaatt acgccgaggc caaggacgtg      960

ttcctgggca tgtttctgta cgagtatgcc aggcgccacc ctgactactc cgtggtgctg     1020

ctgctgcggc tggccaagac ctatgagacc acactggaga agtgctgtgc cgccgccgac     1080

ccccacgagt gctatgcaaa ggtgttcgac gagtttaagc ccctggtgga ggagcctcag     1140

aacctgatca agcagaattg tgagctgttt gagcagctgg gcgagtacaa gttccagaac     1200

gccctgctgg tgagatatac caagaaggtg ccacaggtgt ctacccccac actggtggag     1260

gtgagccgga atctgggcaa ggtcggctcc aagtgctgta agcaccctga ggccaagaga     1320

atgccatgcg ccgaggatta cctgtccgtg gtgctgaacc agctgtgcgt gctgcacgag     1380

aagacccccg tgagcgacag ggtgaccaag tgctgtacag agtctctggt gaaccggaga     1440

ccatgcttta gcgccctgga ggtggatgag acatatgtgc ccaaggagtt caatgccgag     1500

accttcacat ttcacgccga catctgtacc ctgagcgaga aggagcgcca gatcaagaag     1560

cagacagccc tggtggagct ggtgaagcac aagccaaagg ccaccaagga gcagctgaag     1620

gccgtgatgg acgatttcgc cgcctttgtg gagaagtgct gtaaggccga cgataaggag     1680

acatgcttcg cagaggaggg caagaagctg gtggcagcaa gccaggcagc aggaggctcc     1740

ggcggctctc cactgggcct ggccggcggc ggcagcggcg gctccgaggt gcagctggtg     1800

gagtccggcg gcggcctggt gcagcccggc ggcagcctga ggctgtcctg cgccgcctct     1860

ggcttcacct ttaacacata cgcaatgaat tgggtgcgcc aggcaccagg caagggactg     1920

gagtgggtgg cccggatcag aagcaagtac aacaattatg ccacctacta tgccgactcc     1980

gtgaaggatc ggtttaccat cagcagagac gattccaaga acacactgta tctgcagatg     2040

aatagcctgc gggccgagga tacagccgtg tactattgcg tgagacacgg caactttggc     2100

aattcttacg tgagctggtt cgcctattgg ggccagggca ccatggtgac agtgtcctct     2160

gcctctacca agggacctag cgtgttccca ctggcaccta gctccaagtc taccagcgga     2220

ggcacagccg ccctgggatg tctggtgaag gactactttc cagagcccgt gacagtgtcc     2280

tggaactctg gcgccctgac cagcggagtg cacacattcc ctgccgtgct gcagtctagc     2340

ggcctgtact ccctgtcctc tgtggtgacc gtgccaagct cctctctggg cacccagaca     2400

tatatctgca acgtgaatca caagccctct aatacaaagg tggacaagag ggtggagcct     2460

aagagctgcc ccccttgtgg cggaggcggt agccaggtgc agcttcaaga gagcggaccc     2520

ggcctcgtga agcccagcga gaccttgagc ctgacctgca ctgtgagtgg cggtagcgtg     2580

agcagcggcg actattactg gacctggatc aggcagagcc ctggcaaggg gctggagtgg     2640

atcggccaca tctactacag cgggaacacg aactacaacc ccagcctgaa gagcaggctg     2700

acgatcagca tcgacacgag caagacccag ttctcactta agctcagcag cgtgaccgcc     2760

gcagacaccg ccatatacta ctgcgtgagg gacagggtga cgggcgcttt cgacatctgg     2820

ggccaaggca caatggtcac ggtgagctcc ggtgggggtg gcagcggggg aggcggaagc     2880

ggcggaggtg gctctgatat ccagatgacc caaagcccca gtagcctgtc cgccagtgta     2940

ggagataggg taaccatcac ttgccaagcg agccaagaca tcagcaacta cctgaattgg     3000

tatcagcaga agcccggcaa agcacccaag ctcctgatct acgacgccag caatctggag     3060

accggcgtgc ccagcaggtt cagcggatct ggtagcggca ccgacttcac cttcaccata     3120

agtagtctgc agcccgagga catcgccacc tacttctgtc agcacttcga tcacctgccc     3180

ctggccttcg gcggtgggac caaggtggag atcaag                               3216


<210>  145
<211>  1524
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC polypeptide

<400>  145
caggacggca acgaggagat gggcggcatc acccagacac catacaaggt gagcatctcc       60

ggcaccacag tgatcctgac cggaggctcc ggcggctctc cactgggcct ggccggcggc      120

ggcagcggcg gctcccaagc cgtggtaacc caggagccca gtctgacagt gagccctggc      180

ggtacagtga ccttgacttg caggagcagt accggagccg taactacctc aaactacgcc      240

aactgggtgc agcagaagcc cggtcaggcc cccaggggcc ttattggtgg gactaacaaa      300

cgagcacccg gaacccccgc aaggttcagc ggcagccttc tgggcggaaa ggccgctctc      360

acattgagcg gcgtgcagcc cgaggacgag gccgagtact actgcgccct gtggtacagc      420

aacctgtggg tgttcggcgg agggaccaag ctgaccgtgc tgggccagcc caaagctgcg      480

ccgagcgtga ccctgttccc cccgtcaagc gaggagctgc aggctaacaa ggccaccctg      540

gtgtgcctga ttagtgactt ctaccccggt gccgtcaccg tggcctggaa ggccgacagt      600

agcccagtta aagcgggcgt cgagaccacc actcccagca agcagagcaa caacaagtac      660

gccgcgagca gctacctgag tctgaccccc gagcagtgga agagccacag gagctacagc      720

tgccaggtga cccacgaggg cagcactgtg gagaagactg tggccccgac cgagtgcccc      780

ccatgtagcg gcggagggtc ccaggtgcag cttcaagaga gcggacccgg cctcgtgaag      840

cccagcgaga ccttgagcct gacctgcact gtgagtggcg gtagcgtgag cagcggcgac      900

tattactgga cctggatcag gcagagccct ggcaaggggc tggagtggat cggccacatc      960

tactacagcg ggaacacgaa ctacaacccc agcctgaaga gcaggctgac gatcagcatc     1020

gacacgagca agacccagtt ctcacttaag ctcagcagcg tgaccgccgc agacaccgcc     1080

atatactact gcgtgaggga cagggtgacg ggcgctttcg acatctgggg ccaaggcaca     1140

atggtcacgg tgagctccgg tgggggtggc agcgggggag gcggaagcgg cggaggtggc     1200

tctgatatcc agatgaccca aagccccagt agcctgtccg ccagtgtagg agatagggta     1260

accatcactt gccaagcgag ccaagacatc agcaactacc tgaattggta tcagcagaag     1320

cccggcaaag cacccaagct cctgatctac gacgccagca atctggagac cggcgtgccc     1380

agcaggttca gcggatctgg tagcggcacc gacttcacct tcaccataag tagtctgcag     1440

cccgaggaca tcgccaccta cttctgtcag cacttcgatc acctgcccct ggccttcggc     1500

ggtgggacca aggtggagat caag                                            1524


<210>  146
<211>  3216
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC polypeptide

<400>  146
gaggtggccc acaggttcaa ggatctgggc gaggagaact tcaaggccct ggtgctgatc       60

gccttcgccc agtatctgca gcagtgcccc tttgaggacc acgtgaagct ggtgaacgag      120

gtgaccgagt tcgccaagac atgcgtggcc gacgagtccg ccgagaattg tgataagtct      180

ctgcacaccc tgtttggcga taagctgtgc accgtggcca cactgaggga gacatacggc      240

gagatggccg actgctgtgc caagcaggag cccgagcgca acgagtgctt cctgcagcac      300

aaggacgata accctaatct gccacggctg gtgagacctg aggtggacgt gatgtgcacc      360

gccttccacg ataatgagga gacatttctg aagaagtacc tgtatgagat cgcccggaga      420

cacccttact tttatgcccc agagctgctg ttctttgcca agcggtacaa ggcagccttc      480

accgagtgct gtcaggcagc agataaggca gcatgcctgc tgccaaagct ggacgagctg      540

agggatgagg gcaaggcaag ctccgccaag cagcgcctga agtgtgcaag cctgcagaag      600

ttcggagaga gggcctttaa ggcatgggca gtggcaaggc tgtcccagcg gttcccaaag      660

gccgagtttg ccgaggtgtc taagctggtg accgacctga caaaggtgca caccgagtgc      720

tgtcacggcg acctgctgga gtgcgcagac gatagagccg atctggccaa gtacatctgt      780

gagaaccagg actctatctc tagcaagctg aaggagtgct gtgagaagcc cctgctggag      840

aagtcccact gcatcgccga ggtggagaac gacgagatgc cagcagatct gccaagcctg      900

gcagcagact tcgtggagtc caaggacgtg tgcaagaatt acgccgaggc caaggacgtg      960

ttcctgggca tgtttctgta cgagtatgcc aggcgccacc ctgactactc cgtggtgctg     1020

ctgctgcggc tggccaagac ctatgagacc acactggaga agtgctgtgc cgccgccgac     1080

ccccacgagt gctatgcaaa ggtgttcgac gagtttaagc ccctggtgga ggagcctcag     1140

aacctgatca agcagaattg tgagctgttt gagcagctgg gcgagtacaa gttccagaac     1200

gccctgctgg tgagatatac caagaaggtg ccacaggtgt ctacccccac actggtggag     1260

gtgagccgga atctgggcaa ggtcggctcc aagtgctgta agcaccctga ggccaagaga     1320

atgccatgcg ccgaggatta cctgtccgtg gtgctgaacc agctgtgcgt gctgcacgag     1380

aagacccccg tgagcgacag ggtgaccaag tgctgtacag agtctctggt gaaccggaga     1440

ccatgcttta gcgccctgga ggtggatgag acatatgtgc ccaaggagtt caatgccgag     1500

accttcacat ttcacgccga catctgtacc ctgagcgaga aggagcgcca gatcaagaag     1560

cagacagccc tggtggagct ggtgaagcac aagccaaagg ccaccaagga gcagctgaag     1620

gccgtgatgg acgatttcgc cgcctttgtg gagaagtgct gtaaggccga cgataaggag     1680

acatgcttcg cagaggaggg caagaagctg gtggcagcaa gccaggcagc aggaggctcc     1740

ggcggctctg ggggcagcgg aggtagtggc ggcagcggcg gctccgaggt gcagctggtg     1800

gagtccggcg gcggcctggt gcagcccggc ggcagcctga ggctgtcctg cgccgcctct     1860

ggcttcacct ttaacacata cgcaatgaat tgggtgcgcc aggcaccagg caagggactg     1920

gagtgggtgg cccggatcag aagcaagtac aacaattatg ccacctacta tgccgactcc     1980

gtgaaggatc ggtttaccat cagcagagac gattccaaga acacactgta tctgcagatg     2040

aatagcctgc gggccgagga tacagccgtg tactattgcg tgagacacgg caactttggc     2100

aattcttacg tgagctggtt cgcctattgg ggccagggca ccatggtgac agtgtcctct     2160

gcctctacca agggacctag cgtgttccca ctggcaccta gctccaagtc taccagcgga     2220

ggcacagccg ccctgggatg tctggtgaag gactactttc cagagcccgt gacagtgtcc     2280

tggaactctg gcgccctgac cagcggagtg cacacattcc ctgccgtgct gcagtctagc     2340

ggcctgtact ccctgtcctc tgtggtgacc gtgccaagct cctctctggg cacccagaca     2400

tatatctgca acgtgaatca caagccctct aatacaaagg tggacaagag ggtggagcct     2460

aagagctgcc ccccttgtgg cggaggcggt agcgatatcc agatgaccca aagccccagt     2520

agcctgtccg ccagtgtagg agatagggta accatcactt gccaagcgag ccaagacatc     2580

agcaactacc tgaattggta tcagcagaag cccggcaaag cacccaagct cctgatctac     2640

gacgccagca atctggagac cggcgtgccc agcaggttca gcggatctgg tagcggcacc     2700

gacttcacct tcaccataag tagtctgcag cccgaggaca tcgccaccta cttctgtcag     2760

cacttcgatc acctgcccct ggccttcggc ggtgggacca aggtggagat caagggtggg     2820

ggtggcagcg ggggaggcgg aagcggcgga ggtggctctc aggtgcagct tcaagagagc     2880

ggacccggcc tcgtgaagcc cagcgagacc ttgagcctga cctgcactgt gagtggcggt     2940

agcgtgagca gcggcgacta ttactggacc tggatcaggc agagccctgg caaggggctg     3000

gagtggatcg gccacatcta ctacagcggg aacacgaact acaaccccag cctgaagagc     3060

aggctgacga tcagcatcga cacgagcaag acccagttct cacttaagct cagcagcgtg     3120

accgccgcag acaccgccat atactactgc gtgagggaca gggtgacggg cgctttcgac     3180

atctggggcc aaggcacaat ggtcacggtg agctcc                               3216


<210>  147
<211>  1524
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC polypeptide

<400>  147
caggacggca acgaggagat gggcggcatc acccagacac catacaaggt gagcatctcc       60

ggcaccacag tgatcctgac cggaggctcc ggcggctctg ggggcagcgg aggtagtggc      120

ggcagcggcg gctcccaagc cgtggtaacc caggagccca gtctgacagt gagccctggc      180

ggtacagtga ccttgacttg caggagcagt accggagccg taactacctc aaactacgcc      240

aactgggtgc agcagaagcc cggtcaggcc cccaggggcc ttattggtgg gactaacaaa      300

cgagcacccg gaacccccgc aaggttcagc ggcagccttc tgggcggaaa ggccgctctc      360

acattgagcg gcgtgcagcc cgaggacgag gccgagtact actgcgccct gtggtacagc      420

aacctgtggg tgttcggcgg agggaccaag ctgaccgtgc tgggccagcc caaagctgcg      480

ccgagcgtga ccctgttccc cccgtcaagc gaggagctgc aggctaacaa ggccaccctg      540

gtgtgcctga ttagtgactt ctaccccggt gccgtcaccg tggcctggaa ggccgacagt      600

agcccagtta aagcgggcgt cgagaccacc actcccagca agcagagcaa caacaagtac      660

gccgcgagca gctacctgag tctgaccccc gagcagtgga agagccacag gagctacagc      720

tgccaggtga cccacgaggg cagcactgtg gagaagactg tggccccgac cgagtgcccc      780

ccatgtagcg gcggagggtc cgatatccag atgacccaaa gccccagtag cctgtccgcc      840

agtgtaggag atagggtaac catcacttgc caagcgagcc aagacatcag caactacctg      900

aattggtatc agcagaagcc cggcaaagca cccaagctcc tgatctacga cgccagcaat      960

ctggagaccg gcgtgcccag caggttcagc ggatctggta gcggcaccga cttcaccttc     1020

accataagta gtctgcagcc cgaggacatc gccacctact tctgtcagca cttcgatcac     1080

ctgcccctgg ccttcggcgg tgggaccaag gtggagatca agggtggggg tggcagcggg     1140

ggaggcggaa gcggcggagg tggctctcag gtgcagcttc aagagagcgg acccggcctc     1200

gtgaagccca gcgagacctt gagcctgacc tgcactgtga gtggcggtag cgtgagcagc     1260

ggcgactatt actggacctg gatcaggcag agccctggca aggggctgga gtggatcggc     1320

cacatctact acagcgggaa cacgaactac aaccccagcc tgaagagcag gctgacgatc     1380

agcatcgaca cgagcaagac ccagttctca cttaagctca gcagcgtgac cgccgcagac     1440

accgccatat actactgcgt gagggacagg gtgacgggcg ctttcgacat ctggggccaa     1500

ggcacaatgg tcacggtgag ctcc                                            1524


<210>  148
<211>  3216
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC polypeptide

<400>  148
gaggtggccc acaggttcaa ggatctgggc gaggagaact tcaaggccct ggtgctgatc       60

gccttcgccc agtatctgca gcagtgcccc tttgaggacc acgtgaagct ggtgaacgag      120

gtgaccgagt tcgccaagac atgcgtggcc gacgagtccg ccgagaattg tgataagtct      180

ctgcacaccc tgtttggcga taagctgtgc accgtggcca cactgaggga gacatacggc      240

gagatggccg actgctgtgc caagcaggag cccgagcgca acgagtgctt cctgcagcac      300

aaggacgata accctaatct gccacggctg gtgagacctg aggtggacgt gatgtgcacc      360

gccttccacg ataatgagga gacatttctg aagaagtacc tgtatgagat cgcccggaga      420

cacccttact tttatgcccc agagctgctg ttctttgcca agcggtacaa ggcagccttc      480

accgagtgct gtcaggcagc agataaggca gcatgcctgc tgccaaagct ggacgagctg      540

agggatgagg gcaaggcaag ctccgccaag cagcgcctga agtgtgcaag cctgcagaag      600

ttcggagaga gggcctttaa ggcatgggca gtggcaaggc tgtcccagcg gttcccaaag      660

gccgagtttg ccgaggtgtc taagctggtg accgacctga caaaggtgca caccgagtgc      720

tgtcacggcg acctgctgga gtgcgcagac gatagagccg atctggccaa gtacatctgt      780

gagaaccagg actctatctc tagcaagctg aaggagtgct gtgagaagcc cctgctggag      840

aagtcccact gcatcgccga ggtggagaac gacgagatgc cagcagatct gccaagcctg      900

gcagcagact tcgtggagtc caaggacgtg tgcaagaatt acgccgaggc caaggacgtg      960

ttcctgggca tgtttctgta cgagtatgcc aggcgccacc ctgactactc cgtggtgctg     1020

ctgctgcggc tggccaagac ctatgagacc acactggaga agtgctgtgc cgccgccgac     1080

ccccacgagt gctatgcaaa ggtgttcgac gagtttaagc ccctggtgga ggagcctcag     1140

aacctgatca agcagaattg tgagctgttt gagcagctgg gcgagtacaa gttccagaac     1200

gccctgctgg tgagatatac caagaaggtg ccacaggtgt ctacccccac actggtggag     1260

gtgagccgga atctgggcaa ggtcggctcc aagtgctgta agcaccctga ggccaagaga     1320

atgccatgcg ccgaggatta cctgtccgtg gtgctgaacc agctgtgcgt gctgcacgag     1380

aagacccccg tgagcgacag ggtgaccaag tgctgtacag agtctctggt gaaccggaga     1440

ccatgcttta gcgccctgga ggtggatgag acatatgtgc ccaaggagtt caatgccgag     1500

accttcacat ttcacgccga catctgtacc ctgagcgaga aggagcgcca gatcaagaag     1560

cagacagccc tggtggagct ggtgaagcac aagccaaagg ccaccaagga gcagctgaag     1620

gccgtgatgg acgatttcgc cgcctttgtg gagaagtgct gtaaggccga cgataaggag     1680

acatgcttcg cagaggaggg caagaagctg gtggcagcaa gccaggcagc aggaggctcc     1740

ggcggctctg ggggcagcgg aggtagtggc ggcagcggcg gctccgaggt gcagctggtg     1800

gagtccggcg gcggcctggt gcagcccggc ggcagcctga ggctgtcctg cgccgcctct     1860

ggcttcacct ttaacacata cgcaatgaat tgggtgcgcc aggcaccagg caagggactg     1920

gagtgggtgg cccggatcag aagcaagtac aacaattatg ccacctacta tgccgactcc     1980

gtgaaggatc ggtttaccat cagcagagac gattccaaga acacactgta tctgcagatg     2040

aatagcctgc gggccgagga tacagccgtg tactattgcg tgagacacgg caactttggc     2100

aattcttacg tgagctggtt cgcctattgg ggccagggca ccatggtgac agtgtcctct     2160

gcctctacca agggacctag cgtgttccca ctggcaccta gctccaagtc taccagcgga     2220

ggcacagccg ccctgggatg tctggtgaag gactactttc cagagcccgt gacagtgtcc     2280

tggaactctg gcgccctgac cagcggagtg cacacattcc ctgccgtgct gcagtctagc     2340

ggcctgtact ccctgtcctc tgtggtgacc gtgccaagct cctctctggg cacccagaca     2400

tatatctgca acgtgaatca caagccctct aatacaaagg tggacaagag ggtggagcct     2460

aagagctgcc ccccttgtgg cggaggcggt agccaggtgc agcttcaaga gagcggaccc     2520

ggcctcgtga agcccagcga gaccttgagc ctgacctgca ctgtgagtgg cggtagcgtg     2580

agcagcggcg actattactg gacctggatc aggcagagcc ctggcaaggg gctggagtgg     2640

atcggccaca tctactacag cgggaacacg aactacaacc ccagcctgaa gagcaggctg     2700

acgatcagca tcgacacgag caagacccag ttctcactta agctcagcag cgtgaccgcc     2760

gcagacaccg ccatatacta ctgcgtgagg gacagggtga cgggcgcttt cgacatctgg     2820

ggccaaggca caatggtcac ggtgagctcc ggtgggggtg gcagcggggg aggcggaagc     2880

ggcggaggtg gctctgatat ccagatgacc caaagcccca gtagcctgtc cgccagtgta     2940

ggagataggg taaccatcac ttgccaagcg agccaagaca tcagcaacta cctgaattgg     3000

tatcagcaga agcccggcaa agcacccaag ctcctgatct acgacgccag caatctggag     3060

accggcgtgc ccagcaggtt cagcggatct ggtagcggca ccgacttcac cttcaccata     3120

agtagtctgc agcccgagga catcgccacc tacttctgtc agcacttcga tcacctgccc     3180

ctggccttcg gcggtgggac caaggtggag atcaag                               3216


<210>  149
<211>  1524
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC polypeptide

<400>  149
caggacggca acgaggagat gggcggcatc acccagacac catacaaggt gagcatctcc       60

ggcaccacag tgatcctgac cggaggcggc tccggaggcg gtagcggcgg tggatctggc      120

ggcagcggcg gctcccaagc cgtggtaacc caggagccca gtctgacagt gagccctggc      180

ggtacagtga ccttgacttg caggagcagt accggagccg taactacctc aaactacgcc      240

aactgggtgc agcagaagcc cggtcaggcc cccaggggcc ttattggtgg gactaacaaa      300

cgagcacccg gaacccccgc aaggttcagc ggcagccttc tgggcggaaa ggccgctctc      360

acattgagcg gcgtgcagcc cgaggacgag gccgagtact actgcgccct gtggtacagc      420

aacctgtggg tgttcggcgg agggaccaag ctgaccgtgc tgggccagcc caaagctgcg      480

ccgagcgtga ccctgttccc cccgtcaagc gaggagctgc aggctaacaa ggccaccctg      540

gtgtgcctga ttagtgactt ctaccccggt gccgtcaccg tggcctggaa ggccgacagt      600

agcccagtta aagcgggcgt cgagaccacc actcccagca agcagagcaa caacaagtac      660

gccgcgagca gctacctgag tctgaccccc gagcagtgga agagccacag gagctacagc      720

tgccaggtga cccacgaggg cagcactgtg gagaagactg tggccccgac cgagtgcccc      780

ccatgtagcg gcggagggtc ccaggtgcag cttcaagaga gcggacccgg cctcgtgaag      840

cccagcgaga ccttgagcct gacctgcact gtgagtggcg gtagcgtgag cagcggcgac      900

tattactgga cctggatcag gcagagccct ggcaaggggc tggagtggat cggccacatc      960

tactacagcg ggaacacgaa ctacaacccc agcctgaaga gcaggctgac gatcagcatc     1020

gacacgagca agacccagtt ctcacttaag ctcagcagcg tgaccgccgc agacaccgcc     1080

atatactact gcgtgaggga cagggtgacg ggcgctttcg acatctgggg ccaaggcaca     1140

atggtcacgg tgagctccgg tgggggtggc agcgggggag gcggaagcgg cggaggtggc     1200

tctgatatcc agatgaccca aagccccagt agcctgtccg ccagtgtagg agatagggta     1260

accatcactt gccaagcgag ccaagacatc agcaactacc tgaattggta tcagcagaag     1320

cccggcaaag cacccaagct cctgatctac gacgccagca atctggagac cggcgtgccc     1380

agcaggttca gcggatctgg tagcggcacc gacttcacct tcaccataag tagtctgcag     1440

cccgaggaca tcgccaccta cttctgtcag cacttcgatc acctgcccct ggccttcggc     1500

ggtgggacca aggtggagat caag                                            1524


<210>  150
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC polypeptide

<400>  150
ggcggcagcg gcggctccga ggtgcagctg gtggagtccg gcggcggcct ggtgcagccc       60

ggcggcagcc tgaggctgtc ctgcgccgcc tctggcttca cctttaacac atacgcaatg      120

aattgggtgc gccaggcacc aggcaaggga ctggagtggg tggcccggat cagaagcaag      180

tacaacaatt atgccaccta ctatgccgac tccgtgaagg atcggtttac catcagcaga      240

gacgattcca agaacacact gtatctgcag atgaatagcc tgcgggccga ggatacagcc      300

gtgtactatt gcgtgagaca cggcaacttt ggcaattctt acgtgagctg gttcgcctat      360

tggggccagg gcaccatggt gacagtgtcc tctgcctcta ccaagggacc tagcgtgttc      420

ccactggcac ctagctccaa gtctaccagc ggaggcacag ccgccctggg atgtctggtg      480

aaggactact ttccagagcc cgtgacagtg tcctggaact ctggcgccct gaccagcgga      540

gtgcacacat tccctgccgt gctgcagtct agcggcctgt actccctgtc ctctgtggtg      600

accgtgccaa gctcctctct gggcacccag acatatatct gcaacgtgaa tcacaagccc      660

tctaatacaa aggtggacaa gagggtggag cctaagagct gccccccttg tggcggaggc      720

ggtagcgata tccagatgac ccaaagcccc agtagcctgt ccgccagtgt aggagatagg      780

gtaaccatca cttgccaagc gagccaagac atcagcaact acctgaattg gtatcagcag      840

aagcccggca aagcacccaa gctcctgatc tacgacgcca gcaatctgga gaccggcgtg      900

cccagcaggt tcagcggatc tggtagcggc accgacttca ccttcaccat aagtagtctg      960

cagcccgagg acatcgccac ctacttctgt cagcacttcg atcacctgcc cctggccttc     1020

ggcggtggga ccaaggtgga gatcaagggt gggggtggca gcgggggagg cggaagcggc     1080

ggaggtggct ctcaggtgca gcttcaagag agcggacccg gcctcgtgaa gcccagcgag     1140

accttgagcc tgacctgcac tgtgagtggc ggtagcgtga gcagcggcga ctattactgg     1200

acctggatca ggcagagccc tggcaagggg ctggagtgga tcggccacat ctactacagc     1260

gggaacacga actacaaccc cagcctgaag agcaggctga cgatcagcat cgacacgagc     1320

aagacccagt tctcacttaa gctcagcagc gtgaccgccg cagacaccgc catatactac     1380

tgcgtgaggg acagggtgac gggcgctttc gacatctggg gccaaggcac aatggtcacg     1440

gtgagctcc                                                             1449


<210>  151
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC polypeptide

<400>  151
ggcggcagcg gcggctccca agccgtggta acccaggagc ccagtctgac agtgagccct       60

ggcggtacag tgaccttgac ttgcaggagc agtaccggag ccgtaactac ctcaaactac      120

gccaactggg tgcagcagaa gcccggtcag gcccccaggg gccttattgg tgggactaac      180

aaacgagcac ccggaacccc cgcaaggttc agcggcagcc ttctgggcgg aaaggccgct      240

ctcacattga gcggcgtgca gcccgaggac gaggccgagt actactgcgc cctgtggtac      300

agcaacctgt gggtgttcgg cggagggacc aagctgaccg tgctgggcca gcccaaagct      360

gcgccgagcg tgaccctgtt ccccccgtca agcgaggagc tgcaggctaa caaggccacc      420

ctggtgtgcc tgattagtga cttctacccc ggtgccgtca ccgtggcctg gaaggccgac      480

agtagcccag ttaaagcggg cgtcgagacc accactccca gcaagcagag caacaacaag      540

tacgccgcga gcagctacct gagtctgacc cccgagcagt ggaagagcca caggagctac      600

agctgccagg tgacccacga gggcagcact gtggagaaga ctgtggcccc gaccgagtgc      660

cccccatgta gcggcggagg gtccgatatc cagatgaccc aaagccccag tagcctgtcc      720

gccagtgtag gagatagggt aaccatcact tgccaagcga gccaagacat cagcaactac      780

ctgaattggt atcagcagaa gcccggcaaa gcacccaagc tcctgatcta cgacgccagc      840

aatctggaga ccggcgtgcc cagcaggttc agcggatctg gtagcggcac cgacttcacc      900

ttcaccataa gtagtctgca gcccgaggac atcgccacct acttctgtca gcacttcgat      960

cacctgcccc tggccttcgg cggtgggacc aaggtggaga tcaagggtgg gggtggcagc     1020

gggggaggcg gaagcggcgg aggtggctct caggtgcagc ttcaagagag cggacccggc     1080

ctcgtgaagc ccagcgagac cttgagcctg acctgcactg tgagtggcgg tagcgtgagc     1140

agcggcgact attactggac ctggatcagg cagagccctg gcaaggggct ggagtggatc     1200

ggccacatct actacagcgg gaacacgaac tacaacccca gcctgaagag caggctgacg     1260

atcagcatcg acacgagcaa gacccagttc tcacttaagc tcagcagcgt gaccgccgca     1320

gacaccgcca tatactactg cgtgagggac agggtgacgg gcgctttcga catctggggc     1380

caaggcacaa tggtcacggt gagctcc                                         1407


<210>  152
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC polypeptide

<400>  152
ggcggcagcg gcggctccga ggtgcagctg gtggagtccg gcggcggcct ggtgcagccc       60

ggcggcagcc tgaggctgtc ctgcgccgcc tctggcttca cctttaacac atacgcaatg      120

aattgggtgc gccaggcacc aggcaaggga ctggagtggg tggcccggat cagaagcaag      180

tacaacaatt atgccaccta ctatgccgac tccgtgaagg atcggtttac catcagcaga      240

gacgattcca agaacacact gtatctgcag atgaatagcc tgcgggccga ggatacagcc      300

gtgtactatt gcgtgagaca cggcaacttt ggcaattctt acgtgagctg gttcgcctat      360

tggggccagg gcaccatggt gacagtgtcc tctgcctcta ccaagggacc tagcgtgttc      420

ccactggcac ctagctccaa gtctaccagc ggaggcacag ccgccctggg atgtctggtg      480

aaggactact ttccagagcc cgtgacagtg tcctggaact ctggcgccct gaccagcgga      540

gtgcacacat tccctgccgt gctgcagtct agcggcctgt actccctgtc ctctgtggtg      600

accgtgccaa gctcctctct gggcacccag acatatatct gcaacgtgaa tcacaagccc      660

tctaatacaa aggtggacaa gagggtggag cctaagagct gccccccttg tggcggaggc      720

ggtagccagg tgcagcttca agagagcgga cccggcctcg tgaagcccag cgagaccttg      780

agcctgacct gcactgtgag tggcggtagc gtgagcagcg gcgactatta ctggacctgg      840

atcaggcaga gccctggcaa ggggctggag tggatcggcc acatctacta cagcgggaac      900

acgaactaca accccagcct gaagagcagg ctgacgatca gcatcgacac gagcaagacc      960

cagttctcac ttaagctcag cagcgtgacc gccgcagaca ccgccatata ctactgcgtg     1020

agggacaggg tgacgggcgc tttcgacatc tggggccaag gcacaatggt cacggtgagc     1080

tccggtgggg gtggcagcgg gggaggcgga agcggcggag gtggctctga tatccagatg     1140

acccaaagcc ccagtagcct gtccgccagt gtaggagata gggtaaccat cacttgccaa     1200

gcgagccaag acatcagcaa ctacctgaat tggtatcagc agaagcccgg caaagcaccc     1260

aagctcctga tctacgacgc cagcaatctg gagaccggcg tgcccagcag gttcagcgga     1320

tctggtagcg gcaccgactt caccttcacc ataagtagtc tgcagcccga ggacatcgcc     1380

acctacttct gtcagcactt cgatcacctg cccctggcct tcggcggtgg gaccaaggtg     1440

gagatcaag                                                             1449


<210>  153
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC polypeptide

<400>  153
ggcggcagcg gcggctccca agccgtggta acccaggagc ccagtctgac agtgagccct       60

ggcggtacag tgaccttgac ttgcaggagc agtaccggag ccgtaactac ctcaaactac      120

gccaactggg tgcagcagaa gcccggtcag gcccccaggg gccttattgg tgggactaac      180

aaacgagcac ccggaacccc cgcaaggttc agcggcagcc ttctgggcgg aaaggccgct      240

ctcacattga gcggcgtgca gcccgaggac gaggccgagt actactgcgc cctgtggtac      300

agcaacctgt gggtgttcgg cggagggacc aagctgaccg tgctgggcca gcccaaagct      360

gcgccgagcg tgaccctgtt ccccccgtca agcgaggagc tgcaggctaa caaggccacc      420

ctggtgtgcc tgattagtga cttctacccc ggtgccgtca ccgtggcctg gaaggccgac      480

agtagcccag ttaaagcggg cgtcgagacc accactccca gcaagcagag caacaacaag      540

tacgccgcga gcagctacct gagtctgacc cccgagcagt ggaagagcca caggagctac      600

agctgccagg tgacccacga gggcagcact gtggagaaga ctgtggcccc gaccgagtgc      660

cccccatgta gcggcggagg gtcccaggtg cagcttcaag agagcggacc cggcctcgtg      720

aagcccagcg agaccttgag cctgacctgc actgtgagtg gcggtagcgt gagcagcggc      780

gactattact ggacctggat caggcagagc cctggcaagg ggctggagtg gatcggccac      840

atctactaca gcgggaacac gaactacaac cccagcctga agagcaggct gacgatcagc      900

atcgacacga gcaagaccca gttctcactt aagctcagca gcgtgaccgc cgcagacacc      960

gccatatact actgcgtgag ggacagggtg acgggcgctt tcgacatctg gggccaaggc     1020

acaatggtca cggtgagctc cggtgggggt ggcagcgggg gaggcggaag cggcggaggt     1080

ggctctgata tccagatgac ccaaagcccc agtagcctgt ccgccagtgt aggagatagg     1140

gtaaccatca cttgccaagc gagccaagac atcagcaact acctgaattg gtatcagcag     1200

aagcccggca aagcacccaa gctcctgatc tacgacgcca gcaatctgga gaccggcgtg     1260

cccagcaggt tcagcggatc tggtagcggc accgacttca ccttcaccat aagtagtctg     1320

cagcccgagg acatcgccac ctacttctgt cagcacttcg atcacctgcc cctggccttc     1380

ggcggtggga ccaaggtgga gatcaag                                         1407


<210>  154
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker

<400>  154
ggcggcagcg gcggctcc                                                     18


<210>  155
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3VH-CH1

<400>  155
gaggtgcagc tggtggagtc cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

tcctgcgccg cctctggctt cacctttaac acatacgcaa tgaattgggt gcgccaggca      120

ccaggcaagg gactggagtg ggtggcccgg atcagaagca agtacaacaa ttatgccacc      180

tactatgccg actccgtgaa ggatcggttt accatcagca gagacgattc caagaacaca      240

ctgtatctgc agatgaatag cctgcgggcc gaggatacag ccgtgtacta ttgcgtgaga      300

cacggcaact ttggcaattc ttacgtgagc tggttcgcct attggggcca gggcaccatg      360

gtgacagtgt cctctgcctc taccaaggga cctagcgtgt tcccactggc acctagctcc      420

aagtctacca gcggaggcac agccgccctg ggatgtctgg tgaaggacta ctttccagag      480

cccgtgacag tgtcctggaa ctctggcgcc ctgaccagcg gagtgcacac attccctgcc      540

gtgctgcagt ctagcggcct gtactccctg tcctctgtgg tgaccgtgcc aagctcctct      600

ctgggcaccc agacatatat ctgcaacgtg aatcacaagc cctctaatac aaaggtggac      660

aagagggtg                                                              669


<210>  156
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ROR1 (VL-VH)

<400>  156

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Asn Val Ser 
                85                  90                  95      


Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Ser Val Lys Glu Ser Glu Gly Asp Leu Val Thr Pro Ala 
    130                 135                 140                 


Gly Asn Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser Asp Ile Asn Asp 
145                 150                 155                 160 


Tyr Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp Val 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys 
        195                 200                 205             


Met Thr Ser Leu Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
    210                 215                 220                 


Gly Tyr Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly Pro Gly Thr 
225                 230                 235                 240 


Leu Val Thr Ile Ser 
                245 


<210>  157
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-ROR1 (VL-VH)

<400>  157
gacatccaga tgactcagtc ccccagttcc ctgtccgcct ccgtgggcga cagggtgaca       60

atcaactgcc aggcctcaca gtctatcgac agtaaccttg cctggtatca acagaagccc      120

gggaagcccc ccaagctgct gatctacagg gcctccaatc tggcatccgg cgtgccctcc      180

aggttctccg gttccggctc aggcaccgat tttaccctga ccatatcctc cttgcagccc      240

gaggacgtgg ctacctacta ctgtctgggc ggtgtgggca acgtgtccta caggacctcc      300

tttggtggcg gcaccaaggt ggagatcaag ggcggaggag ggtccggtgg agggggcagt      360

ggtgggggag gatcaggagg tggtggctcc cagagtgtga aggagtccga gggcgacctg      420

gtgacccctg ctggcaatct gaccctcacc tgcaccgctt ccggtagcga catcaacgac      480

taccccatat catgggtgag acaggctccc ggcaagggcc tggagtggat cggcttcatc      540

aatagcggtg ggtccacatg gtacgcaagt tgggtgaagg gcaggttcac catctctcga      600

acctcaacta ccgtcgacct gaaaatgacc tccctgacaa ccgacgacac cgcaacctat      660

ttctgcgcca ggggctactc cacatactat ggcgacttca acatctgggg gccagggacc      720

ctggtcacta tctca                                                       735


<210>  158
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  158

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  159
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti CD3 epsilon VL-CL

<400>  159
caagccgtgg taacccagga gcccagtctg acagtgagcc ctggcggtac agtgaccttg       60

acttgcagga gcagtaccgg agccgtaact acctcaaact acgccaactg ggtgcagcag      120

aagcccggtc aggcccccag gggccttatt ggtgggacta acaaacgagc acccggaacc      180

cccgcaaggt tcagcggcag ccttctgggc ggaaaggccg ctctcacatt gagcggcgtg      240

cagcccgagg acgaggccga gtactactgc gccctgtggt acagcaacct gtgggtgttc      300

ggcggaggga ccaagctgac cgtgctgggc cagcccaaag ctgcgccgag cgtgaccctg      360

ttccccccgt caagcgagga gctgcaggct aacaaggcca ccctggtgtg cctgattagt      420

gacttctacc ccggtgccgt caccgtggcc tggaaggccg acagtagccc agttaaagcg      480

ggcgtcgaga ccaccactcc cagcaagcag agcaacaaca agtacgccgc gagcagctac      540

ctgagtctga cccccgagca gtggaagagc cacaggagct acagctgcca ggtgacccac      600

gagggcagca ctgtggagaa gactgtggcc ccgaccgag                             639


<210>  160
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker with cleavable sequence

<400>  160

Gly Gly Ser Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  161
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker with cleavable sequence

<400>  161
ggaggctccg gcggctctcc actgggcctg gccggcggcg gcagcggcgg ctcc             54


<210>  162
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker with non-cleavable sequence

<400>  162

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  163
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker with non-cleavable sequence

<400>  163
ggaggctccg gcggctctgg gggcagcgga ggtagtggcg gcagcggcgg ctcc             54


<210>  164
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAP

<400>  164
caggacggca acgaggagat gggcggcatc acccagacac catacaaggt gagcatctcc       60

ggcaccacag tgatcctgac c                                                 81


<210>  165
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  165

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  166
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ROR1 (VH-VL)

<400>  166

Gln Ser Val Lys Glu Ser Glu Gly Asp Leu Val Thr Pro Ala Gly Asn 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser Asp Ile Asn Asp Tyr Pro 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Tyr 
                85                  90                  95      


Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Ile Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Asp Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu 
    210                 215                 220                 


Gly Gly Val Gly Asn Val Ser Tyr Arg Thr Ser Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  167
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-ROR1 (VH-VL)

<400>  167
cagagtgtga aggagtccga gggcgacctg gtgacccctg ctggcaatct gaccctcacc       60

tgcaccgctt ccggtagcga catcaacgac taccccatat catgggtgag acaggctccc      120

ggcaagggcc tggagtggat cggcttcatc aatagcggtg ggtccacatg gtacgcaagt      180

tgggtgaagg gcaggttcac catctctcga acctcaacta ccgtcgacct gaaaatgacc      240

tccctgacaa ccgacgacac cgcaacctat ttctgcgcca ggggctactc cacatactat      300

ggcgacttca acatctgggg gccagggacc ctggtcacta tctcaggcgg aggagggtcc      360

ggtggagggg gcagtggtgg gggaggatca ggaggtggtg gctccgacat ccagatgact      420

cagtccccca gttccctgtc cgcctccgtg ggcgacaggg tgacaatcaa ctgccaggcc      480

tcacagtcta tcgacagtaa ccttgcctgg tatcaacaga agcccgggaa gccccccaag      540

ctgctgatct acagggcctc caatctggca tccggcgtgc cctccaggtt ctccggttcc      600

ggctcaggca ccgattttac cctgaccata tcctccttgc agcccgagga cgtggctacc      660

tactactgtc tgggcggtgt gggcaacgtg tcctacagga cctcctttgg tggcggcacc      720

aaggtggaga tcaag                                                       735


<210>  168
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PSMA (VL-VH)

<400>  168

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Ala Asn Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Glu Ile Gln 
        115                 120                 125             


Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys 
    130                 135                 140                 


Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His 
145                 150                 155                 160 


Trp Val Lys Gln Asn Asn Gly Glu Ser Leu Glu Trp Ile Gly Tyr Phe 
                165                 170                 175     


Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Asn Gln Asn Phe Asn Gly Lys 
            180                 185                 190         


Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu 
        195                 200                 205             


Asn Ser Leu Thr Ser Glu Asp Ser Ala Phe Tyr Tyr Cys Ala Arg Ser 
    210                 215                 220                 


Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  169
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-PSMA (VL-VH)

<400>  169
gacgtgcaga tcacccagtc cccctcctat ctggccgctt cccccggtga gaccatcacc       60

atcaactgta gggcctccaa gtccatctcc aaatacctgg cctggtatca ggagaagccc      120

ggaaaagcca acaaactgct gatccatagc ggctctaccc tgcagagtgg catcccctcc      180

aggttctcag gctccggttc tggaaccgac tttactctta caatttcctc actcgaaccc      240

gaagacttcg ccatgtacta ctgccagcag cacatcgagt acccctggac cttcggagga      300

ggcactaagc tggagatcaa gagggctggc ggaggtggca gtgggggagg cggttcctcc      360

ggcggtggcg ggagcgagat ccagctgcaa cagtccggtc ccgagctggt gaagcctgga      420

gcctccgtga agatgtcctg taaggcctct ggctacacct ttaccgacta ctacatgcac      480

tgggtaaaac agaacaacgg cgagtccctg gagtggatag gctacttcaa cccctacaac      540

gactacacca ggtacaacca gaacttcaat ggcaaggcca ccctgaccgt ggacaagagc      600

tcctccacag cctatatgca gctcaactcc ctgacttccg aggactccgc cttctactat      660

tgcgccaggt ccgacgggta ctacgacgcc atggactact ggggccaggg cacctcagtg      720

acagtgtcct cc                                                          732


<210>  170
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PSMA (VH-VL)

<400>  170

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Asn Asn Gly Glu Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Asn Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Asp Val Gln Ile Thr Gln Ser Pro Ser 
    130                 135                 140                 


Tyr Leu Ala Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala 
145                 150                 155                 160 


Ser Lys Ser Ile Ser Lys Tyr Leu Ala Trp Tyr Gln Glu Lys Pro Gly 
                165                 170                 175     


Lys Ala Asn Lys Leu Leu Ile His Ser Gly Ser Thr Leu Gln Ser Gly 
            180                 185                 190         


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln His Ile Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Arg Ala 
                


<210>  171
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-PSMA (VH-VL)

<400>  171
gagatccagc tgcaacagtc cggtcccgag ctggtgaagc ctggagcctc cgtgaagatg       60

tcctgtaagg cctctggcta cacctttacc gactactaca tgcactgggt aaaacagaac      120

aacggcgagt ccctggagtg gataggctac ttcaacccct acaacgacta caccaggtac      180

aaccagaact tcaatggcaa ggccaccctg accgtggaca agagctcctc cacagcctat      240

atgcagctca actccctgac ttccgaggac tccgccttct actattgcgc caggtccgac      300

gggtactacg acgccatgga ctactggggc cagggcacct cagtgacagt gtcctccggc      360

ggaggtggca gtgggggagg cggttcctcc ggcggtggcg ggagcgacgt gcagatcacc      420

cagtccccct cctatctggc cgcttccccc ggtgagacca tcaccatcaa ctgtagggcc      480

tccaagtcca tctccaaata cctggcctgg tatcaggaga agcccggaaa agccaacaaa      540

ctgctgatcc atagcggctc taccctgcag agtggcatcc cctccaggtt ctcaggctcc      600

ggttctggaa ccgactttac tcttacaatt tcctcactcg aacccgaaga cttcgccatg      660

tactactgcc agcagcacat cgagtacccc tggaccttcg gaggaggcac taagctggag      720

atcaagaggg ct                                                          732


<210>  172
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-5T4 (VL-VH)

<400>  172

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asp Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe Trp 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Arg Ile Asp Pro Asn Arg Gly Gly Thr Glu Tyr Asn Glu Lys Ala Lys 
            180                 185                 190         


Ser Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Gly Gly Asn Pro Tyr Tyr Pro Met Asp Tyr Trp Gly Gln Gly Thr Thr 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  173
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-5T4 (VL-VH)

<400>  173
gacatacaga tgacccagtc ccccagctcc ctctcagcct ctgtgggcga cagggtgacc       60

atcacctgca gagcttccca aggcatctcc aactacctgg cctggttcca gcagaagcca      120

ggcaaggctc ctaagagcct gatctacagg gctaaccgtc tgcagtccgg cgtgccctcc      180

aggttctctg ggtccggcag cggcacagac ttcaccctta ccatctcctc cctgcagccc      240

gaggacgtag ccacatatta ctgcctgcag tacgatgact tcccctggac tttcggacag      300

ggcaccaagc tggagataaa gggaggtggt ggctcagggg gtgggggctc cggcggaggg      360

gggtctggcg gtggcgggtc ccaggtgcag ctggttcagt ctggtgctga ggtgaagaag      420

cctggcgcct cagttaaagt gtcatgcaag gcctccggct acaccttcac cagtttctgg      480

atgcactggg tgaggcaggc acccggtcag ggcctggagt ggatgggccg aatcgatccc      540

aaccgtggcg gcactgagta caacgagaag gccaagagca gggtcacaat gaccgccgac      600

aagtccacct caactgctta tatggagctg tcctccttgc gttctgagga cactgccgtg      660

tactactgtg caggcggcaa cccctactac cccatggact attgggggca gggtaccact      720

gtcaccgtgt catct                                                       735


<210>  174
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-5T4 (VH-VL)

<400>  174

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Asn Arg Gly Gly Thr Glu Tyr Asn Glu Lys Ala 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Asn Pro Tyr Tyr Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala Trp Phe Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile Tyr Arg Ala Asn Arg Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Leu Gln Tyr Asp Asp Phe Pro Trp Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys 
                245 


<210>  175
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-5T4 (VH-VL)

<400>  175
caggtgcagc tggttcagtc tggtgctgag gtgaagaagc ctggcgcctc agttaaagtg       60

tcatgcaagg cctccggcta caccttcacc agtttctgga tgcactgggt gaggcaggca      120

cccggtcagg gcctggagtg gatgggccga atcgatccca accgtggcgg cactgagtac      180

aacgagaagg ccaagagcag ggtcacaatg accgccgaca agtccacctc aactgcttat      240

atggagctgt cctccttgcg ttctgaggac actgccgtgt actactgtgc aggcggcaac      300

ccctactacc ccatggacta ttgggggcag ggtaccactg tcaccgtgtc atctggaggt      360

ggtggctcag ggggtggggg ctccggcgga ggggggtctg gcggtggcgg gtccgacata      420

cagatgaccc agtcccccag ctccctctca gcctctgtgg gcgacagggt gaccatcacc      480

tgcagagctt cccaaggcat ctccaactac ctggcctggt tccagcagaa gccaggcaag      540

gctcctaaga gcctgatcta cagggctaac cgtctgcagt ccggcgtgcc ctccaggttc      600

tctgggtccg gcagcggcac agacttcacc cttaccatct cctccctgca gcccgaggac      660

gtagccacat attactgcct gcagtacgat gacttcccct ggactttcgg acagggcacc      720

aagctggaga taaag                                                       735



<210>  176
<211>  1119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC 5T4 Polypeptide with MMP 2/9 cleavage protease sequence

<400>  176

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Ala His Arg Phe 
        35                  40                  45              


Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe 
    50                  55                  60                  


Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val 
65                  70                  75                  80  


Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala 
                85                  90                  95      


Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys 
            100                 105                 110         


Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys 
        115                 120                 125             


Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp 
    130                 135                 140                 


Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met 
145                 150                 155                 160 


Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu 
                165                 170                 175     


Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu 
            180                 185                 190         


Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala 
        195                 200                 205             


Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp 
    210                 215                 220                 


Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu 
225                 230                 235                 240 


Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu 
                245                 250                 255     


Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val 
            260                 265                 270         


Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu 
        275                 280                 285             


Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn 
    290                 295                 300                 


Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu 
305                 310                 315                 320 


Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro 
                325                 330                 335     


Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val 
            340                 345                 350         


Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu 
        355                 360                 365             


Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu 
    370                 375                 380                 


Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala 
385                 390                 395                 400 


Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro 
                405                 410                 415     


Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe 
            420                 425                 430         


Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr 
        435                 440                 445             


Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser 
    450                 455                 460                 


Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala 
465                 470                 475                 480 


Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln 
                485                 490                 495     


Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys 
            500                 505                 510         


Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu 
        515                 520                 525             


Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe 
    530                 535                 540                 


Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile 
545                 550                 555                 560 


Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala 
                565                 570                 575     


Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val 
            580                 585                 590         


Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu 
        595                 600                 605             


Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ser Pro Leu Gly Leu Ala Gly Gly Gly Ser Gly Gly Ser Glu Val Gln 
625                 630                 635                 640 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                645                 650                 655     


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn 
            660                 665                 670         


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
        675                 680                 685             


Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
    690                 695                 700                 


Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
705                 710                 715                 720 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                725                 730                 735     


Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp 
            740                 745                 750         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        755                 760                 765             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    770                 775                 780                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
785                 790                 795                 800 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                805                 810                 815     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            820                 825                 830         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        835                 840                 845             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    850                 855                 860                 


Cys Pro Pro Cys Gly Gly Gly Gly Ser Asp Asp Ile Gln Met Thr Gln 
865                 870                 875                 880 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                885                 890                 895     


Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala Trp Phe Gln Gln 
            900                 905                 910         


Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile Tyr Arg Ala Asn Arg Leu 
        915                 920                 925             


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    930                 935                 940                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr 
945                 950                 955                 960 


Tyr Cys Leu Gln Tyr Asp Asp Phe Pro Trp Thr Phe Gly Gln Gly Thr 
                965                 970                 975     


Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            980                 985                 990         


Gly Gly Gly Ser Gly Gly Gly Gly  Ser Gln Val Gln Leu  Val Gln Ser 
        995                 1000                 1005             


Gly Ala  Glu Val Lys Lys Pro  Gly Ala Ser Val Lys  Val Ser Cys 
    1010                 1015                 1020             


Lys Ala  Ser Gly Tyr Thr Phe  Thr Ser Phe Trp Met  His Trp Val 
    1025                 1030                 1035             


Arg Gln  Ala Pro Gly Gln Gly  Leu Glu Trp Met Gly  Arg Ile Asp 
    1040                 1045                 1050             


Pro Asn  Arg Gly Gly Thr Glu  Tyr Asn Glu Lys Ala  Lys Ser Arg 
    1055                 1060                 1065             


Val Thr  Met Thr Ala Asp Lys  Ser Thr Ser Thr Ala  Tyr Met Glu 
    1070                 1075                 1080             


Leu Ser  Ser Leu Arg Ser Glu  Asp Thr Ala Val Tyr  Tyr Cys Ala 
    1085                 1090                 1095             


Gly Gly  Asn Pro Tyr Tyr Pro  Met Asp Tyr Trp Gly  Gln Gly Thr 
    1100                 1105                 1110             


Thr Val  Thr Val Ser Ser 
    1115                 


<210>  177
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC 5T4 Polypeptide

<400>  177

Gly Gly Ser Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu 
1               5                   10                  15      


Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr 
            20                  25                  30          


Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro 
        35                  40                  45              


Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro 
    50                  55                  60                  


Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
65                  70                  75                  80  


Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
        115                 120                 125             


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
    130                 135                 140                 


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
145                 150                 155                 160 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
                165                 170                 175     


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
            180                 185                 190         


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
        195                 200                 205             


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Pro Pro Cys Ser 
    210                 215                 220                 


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
225                 230                 235                 240 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
                245                 250                 255     


Ile Ser Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
            260                 265                 270         


Lys Ser Leu Ile Tyr Arg Ala Asn Arg Leu Gln Ser Gly Val Pro Ser 
        275                 280                 285             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
    290                 295                 300                 


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp 
305                 310                 315                 320 


Asp Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
                325                 330                 335     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        355                 360                 365             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    370                 375                 380                 


Thr Ser Phe Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
385                 390                 395                 400 


Glu Trp Met Gly Arg Ile Asp Pro Asn Arg Gly Gly Thr Glu Tyr Asn 
                405                 410                 415     


Glu Lys Ala Lys Ser Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser 
            420                 425                 430         


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
        435                 440                 445             


Tyr Tyr Cys Ala Gly Gly Asn Pro Tyr Tyr Pro Met Asp Tyr Trp Gly 
    450                 455                 460                 


Gln Gly Thr Thr Val Thr Val Ser Ser 
465                 470             





