                         SEQUENCE LISTING

<110>  Istituto Pasteur Italia - Fondazione Cenci Bolognetti
 
<120>  RIG-I AGONISTS FOR CANCER TREATMENT AND IMMUNOTHERAPY

<130>  I081-0003PCT

<150>  US 62/845,783
<151>  2019-05-09

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  1
gacgaagacc acaaaacca                                                    19


<210>  2
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  2
ugguuuugug gucuucguc                                                    19


<210>  3
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  3
gacgaagacc acaaaaccag au                                                22


<210>  4
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligoribonucleotide

<400>  4
aucugguuuu guggucuucg uc                                                22


<210>  5
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligoribonucleotide

<400>  5
gacgaagacc acaaaaccag auaaaaaaua aaauuuuaau gauaauaaug guuuguuugu       60

cuucguc                                                                 67


<210>  6
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligoribonucleotide

<400>  6
gacgaagacc acaaaaccag auaaaaaaua aaauuuuaau gauaauaaug guuuuguggu       60

cuucguc                                                                 67


<210>  7
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligoribonucleotide

<400>  7
gacgaagacc acaaaaccag auaaaaaaua aaauuuuaau uuuuuaucug guuuguuugu       60

cuucguc                                                                 67


<210>  8
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligoribonucleotide

<400>  8
gacgaagacc acaaaaccag auaaaaaaua aaauuuuaau gauaauaaug guuuguuugu       60

cggaguc                                                                 67


<210>  9
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligoribonucleotide

<400>  9
gacgaagacc acaaaaccau aaugguuuug uggucuucgu c                           41


<210>  10
<211>  59
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligoribonucleotide

<400>  10
gacgaagacc acaaaaccag auaaaaaaua auuuuuuauc ugguuuugug gucuucguc        59


<210>  11
<211>  69
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligoribonucleotide

<400>  11
gacgaagacc acaaaaccag auaaaaaaaa aaauaauuuu uuuuuuuauc ugguuuugug       60

gucuucguc                                                               69


<210>  12
<211>  79
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligoribonucleotide

<400>  12
gacgaagacc acaaaaccag auaaaaaaaa aaaaaaaaua auuuuuuuuu uuuuuuuauc       60

ugguuuugug gucuucguc                                                    79


<210>  13
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligoribonucleotide

<400>  13
gacgaagacc acaaaaccag auaaaaaaaa aaaaaaaaaa aaaaaaaaua auuuuuuuuu       60

uuuuuuuuuu uuuuuuuauc ugguuuugug gucuucguc                              99


<210>  14
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligoribonucleotide

<400>  14
gacgaagacc acaaaaccag auaauaauaa uaauaauaau aauaauaaua auuauuauua       60

uuauuauuau uauuauuauc ugguuuugug gucuucguc                              99


<210>  15
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligoribonucleotide

<400>  15
gcaucguaca gcugcaguua cuuaauucau ugaauaucuu augcauguac uacaugcaua       60

agauauucaa ugaauuaagu aacugcagcu guacgaugc                              99


<210>  16
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  16
gacgaagacc acaaaaccag aucacacaca cacacacaca cacacacaua augugugugu       60

gugugugugu gugugugauc ugguuuugug gucuucguc                              99


<210>  17
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligoribonucleotide

<400>  17
gaccaaccag acaacaagag auaaaaaaaa aaaaaaaaaa aaaaaaaaua auuuuuuuuu       60

uuuuuuuuuu uuuuuuuauc ucuuguuguc ugguugguc                              99


<210>  18
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  18
gacgaagaca aacaaaccat tattatcatt aaaattttat tttttatctg gttttgtggt       60

cttcgtctat agtgagtcgt attaatttc                                         89


<210>  19
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  19
gaaattaata cgactcacta tagacgaaga ccacaaaacc agataaaaaa taaaatttta       60

atgataataa tggtttgttt gtcttcgtc                                         89


<210>  20
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  20
gacgaagacc acaaaaccat tattatcatt aaaattttat tttttatctg gttttgtggt       60

cttcgtctat agtgagtcgt attaatttc                                         89


<210>  21
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  21
gaaattaata cgactcacta tagacgaaga ccacaaaacc agataaaaaa taaaatttta       60

atgataataa tggttttgtg gtcttcgtc                                         89


<210>  22
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  22
gacgaagaca aacaaaccag ataaaaaatt aaaattttat tttttatctg gttttgtggt       60

cttcgtctat agtgagtcgt attaatttc                                         89


<210>  23
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  23
gaaattaata cgactcacta tagacgaaga ccacaaaacc agataaaaaa taaaatttta       60

attttttatc tggtttgttt gtcttcgtc                                         89


<210>  24
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  24
gactccgaca aacaaaccat tattatcatt aaaattttat tttttatctg gttttgtggt       60

cttcgtctat agtgagtcgt attaatttc                                         89


<210>  25
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  25
gaaattaata cgactcacta tagacgaaga ccacaaaacc agataaaaaa taaaatttta       60

atgataataa tggtttgttt gtcggagtc                                         89


<210>  26
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  26
gacgaagacc acaaaaccat tatggttttg tggtcttcgt ctatagtgag tcgtattaat       60

ttc                                                                     63


<210>  27
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  27
gaaattaata cgactcacta tagacgaaga ccacaaaacc ataatggttt tgtggtcttc       60

gtc                                                                     63


<210>  28
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  28
gacgaagacc acaaaaccag ataaaaaatt attttttatc tggttttgtg gtcttcgtct       60

atagtgagtc gtattaattt c                                                 81


<210>  29
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  29
gaaattaata cgactcacta tagacgaaga ccacaaaacc agataaaaaa taatttttta       60

tctggttttg tggtcttcgt c                                                 81


<210>  30
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  30
gacgaagacc acaaaaccag ataaaaaaaa aaattatttt tttttttatc tggttttgtg       60

gtcttcgtct atagtgagtc gtattaattt c                                      91


<210>  31
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  31
gaaattaata cgactcacta tagacgaaga ccacaaaacc agataaaaaa aaaaataatt       60

ttttttttta tctggttttg tggtcttcgt c                                      91


<210>  32
<211>  101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  32
gacgaagacc acaaaaccag ataaaaaaaa aaaaaaaatt attttttttt tttttttatc       60

tggttttgtg gtcttcgtct atagtgagtc gtattaattt c                          101


<210>  33
<211>  101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  33
gaaattaata cgactcacta tagacgaaga ccacaaaacc agataaaaaa aaaaaaaaaa       60

taattttttt ttttttttta tctggttttg tggtcttcgt c                          101


<210>  34
<211>  101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  34
gaaattaata cgactcacta tagacgaaga ccacaaaacc agataaaaaa aaaaaaaaaa       60

taattttttt ttttttttta tctggttttg tggtcttcgt c                          101


<210>  35
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  35
gaaattaata cgactcacta tagacgaaga ccacaaaacc agataaaaaa aaaaaaaaaa       60

aaaaaaaaaa taattttttt tttttttttt ttttttttta tctggttttg tggtcttcgt      120

c                                                                      121


<210>  36
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  36
gacgaagacc acaaaaccag ataataataa taataataat aataataatt attattatta       60

ttattattat tattattatc tggttttgtg gtcttcgtct atagtgagtc gtattaattt      120

c                                                                      121


<210>  37
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  37
gaaattaata cgactcacta tagacgaaga ccacaaaacc agataataat aataataata       60

ataataataa taattattat tattattatt attattatta tctggttttg tggtcttcgt      120

c                                                                      121


<210>  38
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  38
gcatcgtaca gctgcagtta cttaattcat tgaatatctt atgcatgtag tacatgcata       60

agatattcaa tgaattaagt aactgcagct gtacgatgct atagtgagtc gtattaattt      120

c                                                                      121


<210>  39
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  39
gaaattaata cgactcacta tagcatcgta cagctgcagt tacttaattc attgaatatc       60

ttatgcatgt actacatgca taagatattc aatgaattaa gtaactgcag ctgtacgatg      120

c                                                                      121


<210>  40
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  40
gacgaagacc acaaaaccag atcacacaca cacacacaca cacacacatt atgtgtgtgt       60

gtgtgtgtgt gtgtgtgatc tggttttgtg gtcttcgtct atagtgagtc gtattaattt      120

c                                                                      121


<210>  41
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  41
gaaattaata cgactcacta tagacgaaga ccacaaaacc agatcacaca cacacacaca       60

cacacacaca taatgtgtgt gtgtgtgtgt gtgtgtgtga tctggttttg tggtcttcgt      120

c                                                                      121


<210>  42
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  42
gaccaaccag acaacaagag ataaaaaaaa aaaaaaaaaa aaaaaaaatt attttttttt       60

tttttttttt tttttttatc tcttgttgtc tggttggtct atagtgagtc gtattaattt      120

c                                                                      121


<210>  43
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  43
gaaattaata cgactcacta tagaccaacc agacaacaag agataaaaaa aaaaaaaaaa       60

aaaaaaaaaa taattttttt tttttttttt ttttttttta tctcttgttg tctggttggt      120

c                                                                      121


<210>  44
<211>  121
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  44
gacgaagacc acaaaaccag ataaaaaaaa aaaaaaaaaa aaaaaaaatt attttttttt       60

tttttttttt tttttttatc tggttttgtg gtcttcgtct atagtgagtc gtattaattt      120

c                                                                      121


<210>  45
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  45
tcaaacagag gccgcatgcc tatagtgagt cgtatta                                37


<210>  46
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic oliogonucleotide

<400>  46
gcatgcggcc tctgtttgac tatagtgagt cgtatta                                37


<210>  47
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  47
tacgtaagct ggatagcgct atagtgagtc gtatta                                 36


<210>  48
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  48
gcgctatcca gcttacgtat atagtgagtc gtatta                                 36


<210>  49
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  a generic RIG-I oligoribonucleotide; contains SEQ ID NO: 1 to 5' 
       of SEQ ID NO: 2


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  the nucleotide can be present n times, wherein n is any integer 
       greater than 1

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  the nucleotide can be present n times, wherein n is any integer 
       greater than 1

<400>  49
gacgaagacc acaaaaccag auauaauauc ugguuuugug gucuucguc                   49


<210>  50
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  a generic RIG-I oligoribonucleotide; contains SEQ ID NO: 1 to 5' 
       of SEQ ID NO: 2


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  the nucleotide can be present n times, wherein n is any integer 
       greater than 1

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  the nucleotide can be present n times, wherein n is any integer 
       greater than 1

<400>  50
gacgaagacc acaaaaccag auuuaaaauc ugguuuugug gucuucguc                   49


<210>  51
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  a generic RIG-I oligoribonucleotide


<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  the 3-nucleotide stretch can be present x times, wherein x is any
       integer greater than 2

<220>
<221>  misc_feature
<222>  (27)..(29)
<223>  the 3-nucleotide stretch can be present y times, wherein y is any
       integer greater than 2

<400>  51
gacgaagacc acaaaaccag auaauuauua ucugguuuug uggucuucgu c                51


<210>  52
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  a generic RIG-I oligoribonucleotide


<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  the 3-nucleotide stretch can be present x times, wherein x is any
       integer greater than 2

<220>
<221>  misc_feature
<222>  (27)..(29)
<223>  the 3-nucleotide stretch can be present y times, wherein y is any
       integer greater than 2

<400>  52
gacgaagacc acaaaaccag auauuuaaua ucugguuuug uggucuucgu c                51


<210>  53
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  a generic RIG-I oligoribonucleotide; contains SEQ ID NO: 1 to 3' 
       of SEQ ID NO: 2


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  the nucleotide can be present n times, wherein n is an integer 
       greater than 1

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  the nucleotide can be present n times, wherein n is an integer 
       greater than 1

<400>  53
aucugguuuu guggucuucg ucauaaugac gaagaccaca aaaccagau                   49


<210>  54
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  a generic RIG-I oligoribonucleotide; contains SEQ ID NO: 1 to 3' 
       of SEQ ID NO: 2


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  the nucleotide can be present n times, wherein n is any integer 
       greater than 1

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  the nucleotide can be present n times, wherein n is any integer 
       greater than 1

<400>  54
aucugguuuu guggucuucg ucuuaaagac gaagaccaca aaaccagau                   49


