                         SEQUENCE LISTING

<110>  Janssen Biotech, Inc.
       Liu, Changlu
       Liu, Belinda
       Steemers-Lee, Grace
       Sun, Siquan
 
<120>  PAR2 Modulation and Methods Thereof

<130>  JBI6090WOPCT1

<140>  To Be Assigned
<141>  2020-04-30

<150>  62/842869
<151>  2019-05-03

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAR2-AP

<400>  1

Ser Leu Ile Gly Lys Val 
1               5       


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human PAR1 F primer

<400>  2
ccattttggg aggatgagga g                                                 21


<210>  3
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human PAR1 R primer

<400>  3
aggatgaaca caacgatggc cat                                               23


<210>  4
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human PAR2 F primer

<400>  4
atggcacatc ccacgtcact gga                                               23


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human PAR2 R primer

<400>  5
gaaccagatg acagagagga ggtc                                              24


<210>  6
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human PAR3 F primer

<400>  6
atgctaccat ggggtacctg ac                                                22


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human PAR3 R primer

<400>  7
gttgccatag aagatgactg tggt                                              24


<210>  8
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human PAR4 F primer

<400>  8
cctccaccat gctgctgatg aa                                                22


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human PAR4 R primer

<400>  9
aggtctgccg ctgcagtgtc a                                                 21


<210>  10
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Actin F primer

<400>  10
ggtcatcacc attggcaatg ag                                                22


<210>  11
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Actin R primer

<400>  11
gatcttgatc ttcattgtgc tg                                                22


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monkey PAR1 F primer

<400>  12
ccattttggg aggatgagga g                                                 21


<210>  13
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monkey PAR1 R primer

<400>  13
aggatgaaca caacgatggc cat                                               23


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monkey PAR2 F primer

<400>  14
atggcacatc ccacgtcact gga                                               23


<210>  15
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monkey PAR2 R primer

<400>  15
gaaccagatg acagagagga ggtc                                              24


<210>  16
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monkey PAR3 F primer

<400>  16
atgctaccat ggggtacctg ac                                                22


<210>  17
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monkey PAR3 R primer

<400>  17
gttgccatag aagatgactg tggt                                              24


<210>  18
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monkey PAR4 F primer

<400>  18
cctccaccat gctgctgatg aa                                                22


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monkey PAR4 R primer

<400>  19
aggtctgccg ctgcagtgtc a                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monkey Actin F primer

<400>  20
ggcaccacac cttctacaat g                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monkey Actin R primer

<400>  21
ggtccagacg caggatggca t                                                 21


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster PAR1 F primer

<400>  22
cgccagccag aatctgagat g                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster PAR1 R primer

<400>  23
cgaggggatg aagagcctca g                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster PAR2 F primer

<400>  24
ggacgcaacg gtaaaggaag a                                                 21


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster PAR2 R primer

<400>  25
cttcgtccgg aaaaggaaga c                                                 21


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster PAR3 F primer

<400>  26
cttctgccag ccactttttg c                                                 21


<210>  27
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster PAR3 R primer

<400>  27
ggaacttctc aggtatccca tggt                                              24


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster PAR4 F primer

<400>  28
gggaaattct gtgccaacga c                                                 21


<210>  29
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster PAR4 R primer

<400>  29
ggccaatagt aggtccgaaa c                                                 21


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster Actin F primer

<400>  30
gtagccattc aggctgtgct g                                                 21


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster Actin R primer

<400>  31
atgcagcagt ggccatctcc t                                                 21


<210>  32
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAR2 F primer

<400>  32
atgtctgaat tcgccaccat gcggagcccc agcgcggcgt ggctgctg                    48


<210>  33
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAR2 R primer

<400>  33
atgtctgcgg ccgctcaata ggaggtctta acagtggttg aact                        44


<210>  34
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG-Fc PAR2 N-terminus with signal peptide

<400>  34
atgcggagcc ccagcgcggc gtggctgctg ggggccgcca tcctgctagc agcctctctc       60

tcctgcagtg gcaccatcca aggaaccaat agatcctcta aaggaagaag ccttattggt      120

aaggttgatg gcacatccca cgtcactgga aaaggagtta cagttgaaac agtcttttct      180

gtggatgagt tttctgcatc tgtcctcact ggaaaactga ccactggcgc gccaactcac      240

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      300

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      360

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      420

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc      480

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      540

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga      600

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc      660

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat      720

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc      780

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca      840

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct      900

ccgggtaaat ga                                                          912


<210>  35
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG-Fc PAR2 N-terminus with signal peptide

<400>  35

Met Arg Ser Pro Ser Ala Ala Trp Leu Leu Gly Ala Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ala Ser Leu Ser Cys Ser Gly Thr Ile Gln Gly Thr Asn Arg Ser 
            20                  25                  30          


Ser Lys Gly Arg Ser Leu Ile Gly Lys Val Asp Gly Thr Ser His Val 
        35                  40                  45              


Thr Gly Lys Gly Val Thr Val Glu Thr Val Phe Ser Val Asp Glu Phe 
    50                  55                  60                  


Ser Ala Ser Val Leu Thr Gly Lys Leu Thr Thr Gly Ala Pro Thr His 
65                  70                  75                  80  


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                85                  90                  95      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            100                 105                 110         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        115                 120                 125             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    130                 135                 140                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
145                 150                 155                 160 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                165                 170                 175     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            180                 185                 190         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        195                 200                 205             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    210                 215                 220                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
225                 230                 235                 240 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                245                 250                 255     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            260                 265                 270         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        275                 280                 285             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    290                 295                 300             


<210>  36
<211>  843
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG-Fc PAR2 N-terminus without signal peptide

<400>  36
atgaccatcc aaggaaccaa tagatcctct aaaggaagaa gccttattgg taaggttgat       60

ggcacatccc acgtcactgg aaaaggagtt acagttgaaa cagtcttttc tgtggatgag      120

ttttctgcat ctgtcctcac tggaaaactg accactggcg cgccaactca cacatgccca      180

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      240

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      300

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      360

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc      420

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc      480

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag      540

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc      600

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg      660

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac      720

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg      780

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa      840

tga                                                                    843


<210>  37
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG-Fc PAR2 N-terminus without signal peptide

<400>  37

Met Thr Ile Gln Gly Thr Asn Arg Ser Ser Lys Gly Arg Ser Leu Ile 
1               5                   10                  15      


Gly Lys Val Asp Gly Thr Ser His Val Thr Gly Lys Gly Val Thr Val 
            20                  25                  30          


Glu Thr Val Phe Ser Val Asp Glu Phe Ser Ala Ser Val Leu Thr Gly 
        35                  40                  45              


Lys Leu Thr Thr Gly Ala Pro Thr His Thr Cys Pro Pro Cys Pro Ala 
    50                  55                  60                  


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
65                  70                  75                  80  


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                85                  90                  95      


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            100                 105                 110         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        115                 120                 125             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    130                 135                 140                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
145                 150                 155                 160 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                165                 170                 175     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
            180                 185                 190         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        195                 200                 205             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    210                 215                 220                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
225                 230                 235                 240 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                245                 250                 255     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            260                 265                 270         


Ser Leu Ser Leu Ser Pro Gly Lys 
        275                 280 


<210>  38
<211>  777
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG-Fc insulin signal peptide

<400>  38
atggccctgt ggatgcgcct cctgcccctg ctggcgctgc tggccctctg gggacctgac       60

ccagccgcag cctttgtgaa ccaacacctg ggcgcgccaa ctcacacatg cccaccgtgc      120

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      180

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      240

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      300

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg      360

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca      420

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac      480

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc      540

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac      600

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag      660

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat      720

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaatga         777


<210>  39
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG-Fc insulin signal peptide

<400>  39

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Gly Ala 
            20                  25                  30          


Pro Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        35                  40                  45              


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    50                  55                  60                  


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
65                  70                  75                  80  


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                85                  90                  95      


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            100                 105                 110         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        115                 120                 125             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    130                 135                 140                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
145                 150                 155                 160 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                165                 170                 175     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            180                 185                 190         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        195                 200                 205             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    210                 215                 220                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
225                 230                 235                 240 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                245                 250                 255     


Gly Lys 
        


<210>  40
<211>  789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG-Fc insulin receptor signal peptide

<400>  40
atggccaccg ggggccggcg gggggcggcg gccgcgccgc tgctggtggc ggtggccgcg       60

ctgctactgg gcgccgcggg ccacctgtac cccggagagg tgggcgcgcc aactcacaca      120

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca      180

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      240

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      300

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc      360

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac      420

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa      480

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg      540

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg      600

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc      660

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc      720

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg      780

ggtaaatga                                                              789


<210>  41
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG-Fc insulin receptor signal peptide

<400>  41

Met Ala Thr Gly Gly Arg Arg Gly Ala Ala Ala Ala Pro Leu Leu Val 
1               5                   10                  15      


Ala Val Ala Ala Leu Leu Leu Gly Ala Ala Gly His Leu Tyr Pro Gly 
            20                  25                  30          


Glu Val Gly Ala Pro Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys 
            260         


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal PAR2 sequence

<400>  42

Thr Ile Gln Gly Thr Asn Arg 
1               5           


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal PAR2 sequence variant

<400>  43

Thr Ile Gln Gly Thr Asp Arg 
1               5           


<210>  44
<211>  1125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAR2deltaSP

<400>  44
atgaccatcc aaggaaccaa tagatcctct aaaggaagaa gccttattgg taaggttgat       60

ggcacatccc acgtcactgg aaaaggagtt acagttgaaa cagtcttttc tgtggatgag      120

ttttctgcat ctgtcctcac tggaaaactg accactgtct tccttccaat tgtctacaca      180

attgtgtttg tggtgggttt gccaagtaac ggcatggccc tgtgggtctt tcttttccga      240

actaagaaga agcaccctgc tgtgatttac atggccaatc tggccttggc tgacctcctc      300

tctgtcatct ggttcccctt gaagattgcc tatcacatac atggcaacaa ctggatttat      360

ggggaagctc tttgtaatgt gcttattggc tttttctatg gcaacatgta ctgttccatt      420

ctcttcatga cctgcctcag tgtgcagagg tattgggtca tcgtgaaccc catggggcac      480

tccaggaaga aggcaaacat tgccattggc atctccctgg caatatggct gctgattctg      540

ctggtcacca tccctttgta tgtcgtgaag cagaccatct tcattcctgc cctgaacatc      600

acgacctgtc atgatgtttt gcctgagcag ctcttggtgg gagacatgtt caattacttc      660

ctctctctgg ccattggggt ctttctgttc ccagccttcc tcacagcctc tgcctatgtg      720

ctgatgatca gaatgctgcg atcttctgcc atggatgaaa actcagagaa gaaaaggaag      780

agggccatca aactcattgt cactgtcctg gccatgtacc tgatctgctt cactcctagt      840

aaccttctgc ttgtggtgca ttattttctg attaagagcc agggccagag ccatgtctat      900

gccctgtaca ttgtagccct ctgcctctct acccttaaca gctgcatcga cccctttgtc      960

tattactttg tttcacatga tttcagggat catgcaaaga acgctctcct ttgccgaagt     1020

gtccgcactg taaagcagat gcaagtatcc ctcacctcaa agaaacactc caggaaatcc     1080

agctcttact cttcaagttc aaccactgtt aagacctcct attga                     1125


<210>  45
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAR2deltaSP

<400>  45

Met Thr Ile Gln Gly Thr Asn Arg Ser Ser Lys Gly Arg Ser Leu Ile 
1               5                   10                  15      


Gly Lys Val Asp Gly Thr Ser His Val Thr Gly Lys Gly Val Thr Val 
            20                  25                  30          


Glu Thr Val Phe Ser Val Asp Glu Phe Ser Ala Ser Val Leu Thr Gly 
        35                  40                  45              


Lys Leu Thr Thr Val Phe Leu Pro Ile Val Tyr Thr Ile Val Phe Val 
    50                  55                  60                  


Val Gly Leu Pro Ser Asn Gly Met Ala Leu Trp Val Phe Leu Phe Arg 
65                  70                  75                  80  


Thr Lys Lys Lys His Pro Ala Val Ile Tyr Met Ala Asn Leu Ala Leu 
                85                  90                  95      


Ala Asp Leu Leu Ser Val Ile Trp Phe Pro Leu Lys Ile Ala Tyr His 
            100                 105                 110         


Ile His Gly Asn Asn Trp Ile Tyr Gly Glu Ala Leu Cys Asn Val Leu 
        115                 120                 125             


Ile Gly Phe Phe Tyr Gly Asn Met Tyr Cys Ser Ile Leu Phe Met Thr 
    130                 135                 140                 


Cys Leu Ser Val Gln Arg Tyr Trp Val Ile Val Asn Pro Met Gly His 
145                 150                 155                 160 


Ser Arg Lys Lys Ala Asn Ile Ala Ile Gly Ile Ser Leu Ala Ile Trp 
                165                 170                 175     


Leu Leu Ile Leu Leu Val Thr Ile Pro Leu Tyr Val Val Lys Gln Thr 
            180                 185                 190         


Ile Phe Ile Pro Ala Leu Asn Ile Thr Thr Cys His Asp Val Leu Pro 
        195                 200                 205             


Glu Gln Leu Leu Val Gly Asp Met Phe Asn Tyr Phe Leu Ser Leu Ala 
    210                 215                 220                 


Ile Gly Val Phe Leu Phe Pro Ala Phe Leu Thr Ala Ser Ala Tyr Val 
225                 230                 235                 240 


Leu Met Ile Arg Met Leu Arg Ser Ser Ala Met Asp Glu Asn Ser Glu 
                245                 250                 255     


Lys Lys Arg Lys Arg Ala Ile Lys Leu Ile Val Thr Val Leu Ala Met 
            260                 265                 270         


Tyr Leu Ile Cys Phe Thr Pro Ser Asn Leu Leu Leu Val Val His Tyr 
        275                 280                 285             


Phe Leu Ile Lys Ser Gln Gly Gln Ser His Val Tyr Ala Leu Tyr Ile 
    290                 295                 300                 


Val Ala Leu Cys Leu Ser Thr Leu Asn Ser Cys Ile Asp Pro Phe Val 
305                 310                 315                 320 


Tyr Tyr Phe Val Ser His Asp Phe Arg Asp His Ala Lys Asn Ala Leu 
                325                 330                 335     


Leu Cys Arg Ser Val Arg Thr Val Lys Gln Met Gln Val Ser Leu Thr 
            340                 345                 350         


Ser Lys Lys His Ser Arg Lys Ser Ser Ser Tyr Ser Ser Ser Ser Thr 
        355                 360                 365             


Thr Val Lys Thr Ser Tyr 
    370                 


<210>  46
<211>  1212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAR2-INSP

<400>  46
atggccctgt ggatgcgcct cctgcccctg ctggcgctgc tggccctctg gggacctgac       60

ccagccgcag cctttgtgaa ccaacacctg accatccaag gaaccaatag atcctctaaa      120

ggaagaagcc ttattggtaa ggttgatggc acatcccacg tcactggaaa aggagttaca      180

gttgaaacag tcttttctgt ggatgagttt tctgcatctg tcctcactgg aaaactgacc      240

actgtcttcc ttccaattgt ctacacaatt gtgtttgtgg tgggtttgcc aagtaacggc      300

atggccctgt gggtctttct tttccgaact aagaagaagc accctgctgt gatttacatg      360

gccaatctgg ccttggctga cctcctctct gtcatctggt tccccttgaa gattgcctat      420

cacatacatg gcaacaactg gatttatggg gaagctcttt gtaatgtgct tattggcttt      480

ttctatggca acatgtactg ttccattctc ttcatgacct gcctcagtgt gcagaggtat      540

tgggtcatcg tgaaccccat ggggcactcc aggaagaagg caaacattgc cattggcatc      600

tccctggcaa tatggctgct gattctgctg gtcaccatcc ctttgtatgt cgtgaagcag      660

accatcttca ttcctgccct gaacatcacg acctgtcatg atgttttgcc tgagcagctc      720

ttggtgggag acatgttcaa ttacttcctc tctctggcca ttggggtctt tctgttccca      780

gccttcctca cagcctctgc ctatgtgctg atgatcagaa tgctgcgatc ttctgccatg      840

gatgaaaact cagagaagaa aaggaagagg gccatcaaac tcattgtcac tgtcctggcc      900

atgtacctga tctgcttcac tcctagtaac cttctgcttg tggtgcatta ttttctgatt      960

aagagccagg gccagagcca tgtctatgcc ctgtacattg tagccctctg cctctctacc     1020

cttaacagct gcatcgaccc ctttgtctat tactttgttt cacatgattt cagggatcat     1080

gcaaagaacg ctctcctttg ccgaagtgtc cgcactgtaa agcagatgca agtatccctc     1140

acctcaaaga aacactccag gaaatccagc tcttactctt caagttcaac cactgttaag     1200

acctcctatt ga                                                         1212


<210>  47
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAR2-INSP

<400>  47

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Thr Ile 
            20                  25                  30          


Gln Gly Thr Asn Arg Ser Ser Lys Gly Arg Ser Leu Ile Gly Lys Val 
        35                  40                  45              


Asp Gly Thr Ser His Val Thr Gly Lys Gly Val Thr Val Glu Thr Val 
    50                  55                  60                  


Phe Ser Val Asp Glu Phe Ser Ala Ser Val Leu Thr Gly Lys Leu Thr 
65                  70                  75                  80  


Thr Val Phe Leu Pro Ile Val Tyr Thr Ile Val Phe Val Val Gly Leu 
                85                  90                  95      


Pro Ser Asn Gly Met Ala Leu Trp Val Phe Leu Phe Arg Thr Lys Lys 
            100                 105                 110         


Lys His Pro Ala Val Ile Tyr Met Ala Asn Leu Ala Leu Ala Asp Leu 
        115                 120                 125             


Leu Ser Val Ile Trp Phe Pro Leu Lys Ile Ala Tyr His Ile His Gly 
    130                 135                 140                 


Asn Asn Trp Ile Tyr Gly Glu Ala Leu Cys Asn Val Leu Ile Gly Phe 
145                 150                 155                 160 


Phe Tyr Gly Asn Met Tyr Cys Ser Ile Leu Phe Met Thr Cys Leu Ser 
                165                 170                 175     


Val Gln Arg Tyr Trp Val Ile Val Asn Pro Met Gly His Ser Arg Lys 
            180                 185                 190         


Lys Ala Asn Ile Ala Ile Gly Ile Ser Leu Ala Ile Trp Leu Leu Ile 
        195                 200                 205             


Leu Leu Val Thr Ile Pro Leu Tyr Val Val Lys Gln Thr Ile Phe Ile 
    210                 215                 220                 


Pro Ala Leu Asn Ile Thr Thr Cys His Asp Val Leu Pro Glu Gln Leu 
225                 230                 235                 240 


Leu Val Gly Asp Met Phe Asn Tyr Phe Leu Ser Leu Ala Ile Gly Val 
                245                 250                 255     


Phe Leu Phe Pro Ala Phe Leu Thr Ala Ser Ala Tyr Val Leu Met Ile 
            260                 265                 270         


Arg Met Leu Arg Ser Ser Ala Met Asp Glu Asn Ser Glu Lys Lys Arg 
        275                 280                 285             


Lys Arg Ala Ile Lys Leu Ile Val Thr Val Leu Ala Met Tyr Leu Ile 
    290                 295                 300                 


Cys Phe Thr Pro Ser Asn Leu Leu Leu Val Val His Tyr Phe Leu Ile 
305                 310                 315                 320 


Lys Ser Gln Gly Gln Ser His Val Tyr Ala Leu Tyr Ile Val Ala Leu 
                325                 330                 335     


Cys Leu Ser Thr Leu Asn Ser Cys Ile Asp Pro Phe Val Tyr Tyr Phe 
            340                 345                 350         


Val Ser His Asp Phe Arg Asp His Ala Lys Asn Ala Leu Leu Cys Arg 
        355                 360                 365             


Ser Val Arg Thr Val Lys Gln Met Gln Val Ser Leu Thr Ser Lys Lys 
    370                 375                 380                 


His Ser Arg Lys Ser Ser Ser Tyr Ser Ser Ser Ser Thr Thr Val Lys 
385                 390                 395                 400 


Thr Ser Tyr 
            


<210>  48
<211>  1224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAR2-IRSP

<400>  48
atggccaccg ggggccggcg gggggcggcg gccgcgccgc tgctggtggc ggtggccgcg       60

ctgctactgg gcgccgcggg ccacctgtac cccggagagg tgaccatcca aggaaccaat      120

agatcctcta aaggaagaag ccttattggt aaggttgatg gcacatccca cgtcactgga      180

aaaggagtta cagttgaaac agtcttttct gtggatgagt tttctgcatc tgtcctcact      240

ggaaaactga ccactgtctt ccttccaatt gtctacacaa ttgtgtttgt ggtgggtttg      300

ccaagtaacg gcatggccct gtgggtcttt cttttccgaa ctaagaagaa gcaccctgct      360

gtgatttaca tggccaatct ggccttggct gacctcctct ctgtcatctg gttccccttg      420

aagattgcct atcacataca tggcaacaac tggatttatg gggaagctct ttgtaatgtg      480

cttattggct ttttctatgg caacatgtac tgttccattc tcttcatgac ctgcctcagt      540

gtgcagaggt attgggtcat cgtgaacccc atggggcact ccaggaagaa ggcaaacatt      600

gccattggca tctccctggc aatatggctg ctgattctgc tggtcaccat ccctttgtat      660

gtcgtgaagc agaccatctt cattcctgcc ctgaacatca cgacctgtca tgatgttttg      720

cctgagcagc tcttggtggg agacatgttc aattacttcc tctctctggc cattggggtc      780

tttctgttcc cagccttcct cacagcctct gcctatgtgc tgatgatcag aatgctgcga      840

tcttctgcca tggatgaaaa ctcagagaag aaaaggaaga gggccatcaa actcattgtc      900

actgtcctgg ccatgtacct gatctgcttc actcctagta accttctgct tgtggtgcat      960

tattttctga ttaagagcca gggccagagc catgtctatg ccctgtacat tgtagccctc     1020

tgcctctcta cccttaacag ctgcatcgac ccctttgtct attactttgt ttcacatgat     1080

ttcagggatc atgcaaagaa cgctctcctt tgccgaagtg tccgcactgt aaagcagatg     1140

caagtatccc tcacctcaaa gaaacactcc aggaaatcca gctcttactc ttcaagttca     1200

accactgtta agacctccta ttga                                            1224


<210>  49
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAR2-IRSP

<400>  49

Met Ala Thr Gly Gly Arg Arg Gly Ala Ala Ala Ala Pro Leu Leu Val 
1               5                   10                  15      


Ala Val Ala Ala Leu Leu Leu Gly Ala Ala Gly His Leu Tyr Pro Gly 
            20                  25                  30          


Glu Val Thr Ile Gln Gly Thr Asn Arg Ser Ser Lys Gly Arg Ser Leu 
        35                  40                  45              


Ile Gly Lys Val Asp Gly Thr Ser His Val Thr Gly Lys Gly Val Thr 
    50                  55                  60                  


Val Glu Thr Val Phe Ser Val Asp Glu Phe Ser Ala Ser Val Leu Thr 
65                  70                  75                  80  


Gly Lys Leu Thr Thr Val Phe Leu Pro Ile Val Tyr Thr Ile Val Phe 
                85                  90                  95      


Val Val Gly Leu Pro Ser Asn Gly Met Ala Leu Trp Val Phe Leu Phe 
            100                 105                 110         


Arg Thr Lys Lys Lys His Pro Ala Val Ile Tyr Met Ala Asn Leu Ala 
        115                 120                 125             


Leu Ala Asp Leu Leu Ser Val Ile Trp Phe Pro Leu Lys Ile Ala Tyr 
    130                 135                 140                 


His Ile His Gly Asn Asn Trp Ile Tyr Gly Glu Ala Leu Cys Asn Val 
145                 150                 155                 160 


Leu Ile Gly Phe Phe Tyr Gly Asn Met Tyr Cys Ser Ile Leu Phe Met 
                165                 170                 175     


Thr Cys Leu Ser Val Gln Arg Tyr Trp Val Ile Val Asn Pro Met Gly 
            180                 185                 190         


His Ser Arg Lys Lys Ala Asn Ile Ala Ile Gly Ile Ser Leu Ala Ile 
        195                 200                 205             


Trp Leu Leu Ile Leu Leu Val Thr Ile Pro Leu Tyr Val Val Lys Gln 
    210                 215                 220                 


Thr Ile Phe Ile Pro Ala Leu Asn Ile Thr Thr Cys His Asp Val Leu 
225                 230                 235                 240 


Pro Glu Gln Leu Leu Val Gly Asp Met Phe Asn Tyr Phe Leu Ser Leu 
                245                 250                 255     


Ala Ile Gly Val Phe Leu Phe Pro Ala Phe Leu Thr Ala Ser Ala Tyr 
            260                 265                 270         


Val Leu Met Ile Arg Met Leu Arg Ser Ser Ala Met Asp Glu Asn Ser 
        275                 280                 285             


Glu Lys Lys Arg Lys Arg Ala Ile Lys Leu Ile Val Thr Val Leu Ala 
    290                 295                 300                 


Met Tyr Leu Ile Cys Phe Thr Pro Ser Asn Leu Leu Leu Val Val His 
305                 310                 315                 320 


Tyr Phe Leu Ile Lys Ser Gln Gly Gln Ser His Val Tyr Ala Leu Tyr 
                325                 330                 335     


Ile Val Ala Leu Cys Leu Ser Thr Leu Asn Ser Cys Ile Asp Pro Phe 
            340                 345                 350         


Val Tyr Tyr Phe Val Ser His Asp Phe Arg Asp His Ala Lys Asn Ala 
        355                 360                 365             


Leu Leu Cys Arg Ser Val Arg Thr Val Lys Gln Met Gln Val Ser Leu 
    370                 375                 380                 


Thr Ser Lys Lys His Ser Arg Lys Ser Ser Ser Tyr Ser Ser Ser Ser 
385                 390                 395                 400 


Thr Thr Val Lys Thr Ser Tyr 
                405         


<210>  50
<211>  1071
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAR2deltaSPdeltaL

<400>  50
atggatggca catcccacgt cactggaaaa ggagttacag ttgaaacagt cttttctgtg       60

gatgagtttt ctgcatctgt cctcactgga aaactgacca ctgtcttcct tccaattgtc      120

tacacaattg tgtttgtggt gggtttgcca agtaacggca tggccctgtg ggtctttctt      180

ttccgaacta agaagaagca ccctgctgtg atttacatgg ccaatctggc cttggctgac      240

ctcctctctg tcatctggtt ccccttgaag attgcctatc acatacatgg caacaactgg      300

atttatgggg aagctctttg taatgtgctt attggctttt tctatggcaa catgtactgt      360

tccattctct tcatgacctg cctcagtgtg cagaggtatt gggtcatcgt gaaccccatg      420

gggcactcca ggaagaaggc aaacattgcc attggcatct ccctggcaat atggctgctg      480

attctgctgg tcaccatccc tttgtatgtc gtgaagcaga ccatcttcat tcctgccctg      540

aacatcacga cctgtcatga tgttttgcct gagcagctct tggtgggaga catgttcaat      600

tacttcctct ctctggccat tggggtcttt ctgttcccag ccttcctcac agcctctgcc      660

tatgtgctga tgatcagaat gctgcgatct tctgccatgg atgaaaactc agagaagaaa      720

aggaagaggg ccatcaaact cattgtcact gtcctggcca tgtacctgat ctgcttcact      780

cctagtaacc ttctgcttgt ggtgcattat tttctgatta agagccaggg ccagagccat      840

gtctatgccc tgtacattgt agccctctgc ctctctaccc ttaacagctg catcgacccc      900

tttgtctatt actttgtttc acatgatttc agggatcatg caaagaacgc tctcctttgc      960

cgaagtgtcc gcactgtaaa gcagatgcaa gtatccctca cctcaaagaa acactccagg     1020

aaatccagct cttactcttc aagttcaacc actgttaaga cctcctattg a              1071


<210>  51
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAR2deltaSPdeltaL

<400>  51

Met Asp Gly Thr Ser His Val Thr Gly Lys Gly Val Thr Val Glu Thr 
1               5                   10                  15      


Val Phe Ser Val Asp Glu Phe Ser Ala Ser Val Leu Thr Gly Lys Leu 
            20                  25                  30          


Thr Thr Val Phe Leu Pro Ile Val Tyr Thr Ile Val Phe Val Val Gly 
        35                  40                  45              


Leu Pro Ser Asn Gly Met Ala Leu Trp Val Phe Leu Phe Arg Thr Lys 
    50                  55                  60                  


Lys Lys His Pro Ala Val Ile Tyr Met Ala Asn Leu Ala Leu Ala Asp 
65                  70                  75                  80  


Leu Leu Ser Val Ile Trp Phe Pro Leu Lys Ile Ala Tyr His Ile His 
                85                  90                  95      


Gly Asn Asn Trp Ile Tyr Gly Glu Ala Leu Cys Asn Val Leu Ile Gly 
            100                 105                 110         


Phe Phe Tyr Gly Asn Met Tyr Cys Ser Ile Leu Phe Met Thr Cys Leu 
        115                 120                 125             


Ser Val Gln Arg Tyr Trp Val Ile Val Asn Pro Met Gly His Ser Arg 
    130                 135                 140                 


Lys Lys Ala Asn Ile Ala Ile Gly Ile Ser Leu Ala Ile Trp Leu Leu 
145                 150                 155                 160 


Ile Leu Leu Val Thr Ile Pro Leu Tyr Val Val Lys Gln Thr Ile Phe 
                165                 170                 175     


Ile Pro Ala Leu Asn Ile Thr Thr Cys His Asp Val Leu Pro Glu Gln 
            180                 185                 190         


Leu Leu Val Gly Asp Met Phe Asn Tyr Phe Leu Ser Leu Ala Ile Gly 
        195                 200                 205             


Val Phe Leu Phe Pro Ala Phe Leu Thr Ala Ser Ala Tyr Val Leu Met 
    210                 215                 220                 


Ile Arg Met Leu Arg Ser Ser Ala Met Asp Glu Asn Ser Glu Lys Lys 
225                 230                 235                 240 


Arg Lys Arg Ala Ile Lys Leu Ile Val Thr Val Leu Ala Met Tyr Leu 
                245                 250                 255     


Ile Cys Phe Thr Pro Ser Asn Leu Leu Leu Val Val His Tyr Phe Leu 
            260                 265                 270         


Ile Lys Ser Gln Gly Gln Ser His Val Tyr Ala Leu Tyr Ile Val Ala 
        275                 280                 285             


Leu Cys Leu Ser Thr Leu Asn Ser Cys Ile Asp Pro Phe Val Tyr Tyr 
    290                 295                 300                 


Phe Val Ser His Asp Phe Arg Asp His Ala Lys Asn Ala Leu Leu Cys 
305                 310                 315                 320 


Arg Ser Val Arg Thr Val Lys Gln Met Gln Val Ser Leu Thr Ser Lys 
                325                 330                 335     


Lys His Ser Arg Lys Ser Ser Ser Tyr Ser Ser Ser Ser Thr Thr Val 
            340                 345                 350         


Lys Thr Ser Tyr 
        355     


<210>  52
<211>  1125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAR2deltaSP(R36A)

<400>  52
atgaccatcc aaggaaccaa tagatcctct aaaggagcaa gccttattgg taaggttgat       60

ggcacatccc acgtcactgg aaaaggagtt acagttgaaa cagtcttttc tgtggatgag      120

ttttctgcat ctgtcctcac tggaaaactg accactgtct tccttccaat tgtctacaca      180

attgtgtttg tggtgggttt gccaagtaac ggcatggccc tgtgggtctt tcttttccga      240

actaagaaga agcaccctgc tgtgatttac atggccaatc tggccttggc tgacctcctc      300

tctgtcatct ggttcccctt gaagattgcc tatcacatac atggcaacaa ctggatttat      360

ggggaagctc tttgtaatgt gcttattggc tttttctatg gcaacatgta ctgttccatt      420

ctcttcatga cctgcctcag tgtgcagagg tattgggtca tcgtgaaccc catggggcac      480

tccaggaaga aggcaaacat tgccattggc atctccctgg caatatggct gctgattctg      540

ctggtcacca tccctttgta tgtcgtgaag cagaccatct tcattcctgc cctgaacatc      600

acgacctgtc atgatgtttt gcctgagcag ctcttggtgg gagacatgtt caattacttc      660

ctctctctgg ccattggggt ctttctgttc ccagccttcc tcacagcctc tgcctatgtg      720

ctgatgatca gaatgctgcg atcttctgcc atggatgaaa actcagagaa gaaaaggaag      780

agggccatca aactcattgt cactgtcctg gccatgtacc tgatctgctt cactcctagt      840

aaccttctgc ttgtggtgca ttattttctg attaagagcc agggccagag ccatgtctat      900

gccctgtaca ttgtagccct ctgcctctct acccttaaca gctgcatcga cccctttgtc      960

tattactttg tttcacatga tttcagggat catgcaaaga acgctctcct ttgccgaagt     1020

gtccgcactg taaagcagat gcaagtatcc ctcacctcaa agaaacactc caggaaatcc     1080

agctcttact cttcaagttc aaccactgtt aagacctcct attga                     1125


<210>  53
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAR2deltaSP(R36A)

<400>  53

Met Thr Ile Gln Gly Thr Asn Arg Ser Ser Lys Gly Ala Ser Leu Ile 
1               5                   10                  15      


Gly Lys Val Asp Gly Thr Ser His Val Thr Gly Lys Gly Val Thr Val 
            20                  25                  30          


Glu Thr Val Phe Ser Val Asp Glu Phe Ser Ala Ser Val Leu Thr Gly 
        35                  40                  45              


Lys Leu Thr Thr Val Phe Leu Pro Ile Val Tyr Thr Ile Val Phe Val 
    50                  55                  60                  


Val Gly Leu Pro Ser Asn Gly Met Ala Leu Trp Val Phe Leu Phe Arg 
65                  70                  75                  80  


Thr Lys Lys Lys His Pro Ala Val Ile Tyr Met Ala Asn Leu Ala Leu 
                85                  90                  95      


Ala Asp Leu Leu Ser Val Ile Trp Phe Pro Leu Lys Ile Ala Tyr His 
            100                 105                 110         


Ile His Gly Asn Asn Trp Ile Tyr Gly Glu Ala Leu Cys Asn Val Leu 
        115                 120                 125             


Ile Gly Phe Phe Tyr Gly Asn Met Tyr Cys Ser Ile Leu Phe Met Thr 
    130                 135                 140                 


Cys Leu Ser Val Gln Arg Tyr Trp Val Ile Val Asn Pro Met Gly His 
145                 150                 155                 160 


Ser Arg Lys Lys Ala Asn Ile Ala Ile Gly Ile Ser Leu Ala Ile Trp 
                165                 170                 175     


Leu Leu Ile Leu Leu Val Thr Ile Pro Leu Tyr Val Val Lys Gln Thr 
            180                 185                 190         


Ile Phe Ile Pro Ala Leu Asn Ile Thr Thr Cys His Asp Val Leu Pro 
        195                 200                 205             


Glu Gln Leu Leu Val Gly Asp Met Phe Asn Tyr Phe Leu Ser Leu Ala 
    210                 215                 220                 


Ile Gly Val Phe Leu Phe Pro Ala Phe Leu Thr Ala Ser Ala Tyr Val 
225                 230                 235                 240 


Leu Met Ile Arg Met Leu Arg Ser Ser Ala Met Asp Glu Asn Ser Glu 
                245                 250                 255     


Lys Lys Arg Lys Arg Ala Ile Lys Leu Ile Val Thr Val Leu Ala Met 
            260                 265                 270         


Tyr Leu Ile Cys Phe Thr Pro Ser Asn Leu Leu Leu Val Val His Tyr 
        275                 280                 285             


Phe Leu Ile Lys Ser Gln Gly Gln Ser His Val Tyr Ala Leu Tyr Ile 
    290                 295                 300                 


Val Ala Leu Cys Leu Ser Thr Leu Asn Ser Cys Ile Asp Pro Phe Val 
305                 310                 315                 320 


Tyr Tyr Phe Val Ser His Asp Phe Arg Asp His Ala Lys Asn Ala Leu 
                325                 330                 335     


Leu Cys Arg Ser Val Arg Thr Val Lys Gln Met Gln Val Ser Leu Thr 
            340                 345                 350         


Ser Lys Lys His Ser Arg Lys Ser Ser Ser Tyr Ser Ser Ser Ser Thr 
        355                 360                 365             


Thr Val Lys Thr Ser Tyr 
    370                 


<210>  54
<211>  1194
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAR2(R36A)

<400>  54
atgcggagcc ccagcgcggc gtggctgctg ggggccgcca tcctgctagc agcctctctc       60

tcctgcagtg gcaccatcca aggaaccaat agatcctcta aaggagcaag ccttattggt      120

aaggttgatg gcacatccca cgtcactgga aaaggagtta cagttgaaac agtcttttct      180

gtggatgagt tttctgcatc tgtcctcact ggaaaactga ccactgtctt ccttccaatt      240

gtctacacaa ttgtgtttgt ggtgggtttg ccaagtaacg gcatggccct gtgggtcttt      300

cttttccgaa ctaagaagaa gcaccctgct gtgatttaca tggccaatct ggccttggct      360

gacctcctct ctgtcatctg gttccccttg aagattgcct atcacataca tggcaacaac      420

tggatttatg gggaagctct ttgtaatgtg cttattggct ttttctatgg caacatgtac      480

tgttccattc tcttcatgac ctgcctcagt gtgcagaggt attgggtcat cgtgaacccc      540

atggggcact ccaggaagaa ggcaaacatt gccattggca tctccctggc aatatggctg      600

ctgattctgc tggtcaccat ccctttgtat gtcgtgaagc agaccatctt cattcctgcc      660

ctgaacatca cgacctgtca tgatgttttg cctgagcagc tcttggtggg agacatgttc      720

aattacttcc tctctctggc cattggggtc tttctgttcc cagccttcct cacagcctct      780

gcctatgtgc tgatgatcag aatgctgcga tcttctgcca tggatgaaaa ctcagagaag      840

aaaaggaaga gggccatcaa actcattgtc actgtcctgg ccatgtacct gatctgcttc      900

actcctagta accttctgct tgtggtgcat tattttctga ttaagagcca gggccagagc      960

catgtctatg ccctgtacat tgtagccctc tgcctctcta cccttaacag ctgcatcgac     1020

ccctttgtct attactttgt ttcacatgat ttcagggatc atgcaaagaa cgctctcctt     1080

tgccgaagtg tccgcactgt aaagcagatg caagtatccc tcacctcaaa gaaacactcc     1140

aggaaatcca gctcttactc ttcaagttca accactgtta agacctccta ttga           1194


<210>  55
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAR2(R36A)

<400>  55

Met Arg Ser Pro Ser Ala Ala Trp Leu Leu Gly Ala Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ala Ser Leu Ser Cys Ser Gly Thr Ile Gln Gly Thr Asn Arg Ser 
            20                  25                  30          


Ser Lys Gly Ala Ser Leu Ile Gly Lys Val Asp Gly Thr Ser His Val 
        35                  40                  45              


Thr Gly Lys Gly Val Thr Val Glu Thr Val Phe Ser Val Asp Glu Phe 
    50                  55                  60                  


Ser Ala Ser Val Leu Thr Gly Lys Leu Thr Thr Val Phe Leu Pro Ile 
65                  70                  75                  80  


Val Tyr Thr Ile Val Phe Val Val Gly Leu Pro Ser Asn Gly Met Ala 
                85                  90                  95      


Leu Trp Val Phe Leu Phe Arg Thr Lys Lys Lys His Pro Ala Val Ile 
            100                 105                 110         


Tyr Met Ala Asn Leu Ala Leu Ala Asp Leu Leu Ser Val Ile Trp Phe 
        115                 120                 125             


Pro Leu Lys Ile Ala Tyr His Ile His Gly Asn Asn Trp Ile Tyr Gly 
    130                 135                 140                 


Glu Ala Leu Cys Asn Val Leu Ile Gly Phe Phe Tyr Gly Asn Met Tyr 
145                 150                 155                 160 


Cys Ser Ile Leu Phe Met Thr Cys Leu Ser Val Gln Arg Tyr Trp Val 
                165                 170                 175     


Ile Val Asn Pro Met Gly His Ser Arg Lys Lys Ala Asn Ile Ala Ile 
            180                 185                 190         


Gly Ile Ser Leu Ala Ile Trp Leu Leu Ile Leu Leu Val Thr Ile Pro 
        195                 200                 205             


Leu Tyr Val Val Lys Gln Thr Ile Phe Ile Pro Ala Leu Asn Ile Thr 
    210                 215                 220                 


Thr Cys His Asp Val Leu Pro Glu Gln Leu Leu Val Gly Asp Met Phe 
225                 230                 235                 240 


Asn Tyr Phe Leu Ser Leu Ala Ile Gly Val Phe Leu Phe Pro Ala Phe 
                245                 250                 255     


Leu Thr Ala Ser Ala Tyr Val Leu Met Ile Arg Met Leu Arg Ser Ser 
            260                 265                 270         


Ala Met Asp Glu Asn Ser Glu Lys Lys Arg Lys Arg Ala Ile Lys Leu 
        275                 280                 285             


Ile Val Thr Val Leu Ala Met Tyr Leu Ile Cys Phe Thr Pro Ser Asn 
    290                 295                 300                 


Leu Leu Leu Val Val His Tyr Phe Leu Ile Lys Ser Gln Gly Gln Ser 
305                 310                 315                 320 


His Val Tyr Ala Leu Tyr Ile Val Ala Leu Cys Leu Ser Thr Leu Asn 
                325                 330                 335     


Ser Cys Ile Asp Pro Phe Val Tyr Tyr Phe Val Ser His Asp Phe Arg 
            340                 345                 350         


Asp His Ala Lys Asn Ala Leu Leu Cys Arg Ser Val Arg Thr Val Lys 
        355                 360                 365             


Gln Met Gln Val Ser Leu Thr Ser Lys Lys His Ser Arg Lys Ser Ser 
    370                 375                 380                 


Ser Tyr Ser Ser Ser Ser Thr Thr Val Lys Thr Ser Tyr 
385                 390                 395         


<210>  56
<211>  1194
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAR2 WT

<400>  56
atgcggagcc ccagcgcggc gtggctgctg ggggccgcca tcctgctagc agcctctctc       60

tcctgcagtg gcaccatcca aggaaccaat agatcctcta aaggaagaag ccttattggt      120

aaggttgatg gcacatccca cgtcactgga aaaggagtta cagttgaaac agtcttttct      180

gtggatgagt tttctgcatc tgtcctcact ggaaaactga ccactgtctt ccttccaatt      240

gtctacacaa ttgtgtttgt ggtgggtttg ccaagtaacg gcatggccct gtgggtcttt      300

cttttccgaa ctaagaagaa gcaccctgct gtgatttaca tggccaatct ggccttggct      360

gacctcctct ctgtcatctg gttccccttg aagattgcct atcacataca tggcaacaac      420

tggatttatg gggaagctct ttgtaatgtg cttattggct ttttctatgg caacatgtac      480

tgttccattc tcttcatgac ctgcctcagt gtgcagaggt attgggtcat cgtgaacccc      540

atggggcact ccaggaagaa ggcaaacatt gccattggca tctccctggc aatatggctg      600

ctgattctgc tggtcaccat ccctttgtat gtcgtgaagc agaccatctt cattcctgcc      660

ctgaacatca cgacctgtca tgatgttttg cctgagcagc tcttggtggg agacatgttc      720

aattacttcc tctctctggc cattggggtc tttctgttcc cagccttcct cacagcctct      780

gcctatgtgc tgatgatcag aatgctgcga tcttctgcca tggatgaaaa ctcagagaag      840

aaaaggaaga gggccatcaa actcattgtc actgtcctgg ccatgtacct gatctgcttc      900

actcctagta accttctgct tgtggtgcat tattttctga ttaagagcca gggccagagc      960

catgtctatg ccctgtacat tgtagccctc tgcctctcta cccttaacag ctgcatcgac     1020

ccctttgtct attactttgt ttcacatgat ttcagggatc atgcaaagaa cgctctcctt     1080

tgccgaagtg tccgcactgt aaagcagatg caagtatccc tcacctcaaa gaaacactcc     1140

aggaaatcca gctcttactc ttcaagttca accactgtta agacctccta ttga           1194


<210>  57
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAR2 WT

<400>  57

Met Arg Ser Pro Ser Ala Ala Trp Leu Leu Gly Ala Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ala Ser Leu Ser Cys Ser Gly Thr Ile Gln Gly Thr Asn Arg Ser 
            20                  25                  30          


Ser Lys Gly Arg Ser Leu Ile Gly Lys Val Asp Gly Thr Ser His Val 
        35                  40                  45              


Thr Gly Lys Gly Val Thr Val Glu Thr Val Phe Ser Val Asp Glu Phe 
    50                  55                  60                  


Ser Ala Ser Val Leu Thr Gly Lys Leu Thr Thr Val Phe Leu Pro Ile 
65                  70                  75                  80  


Val Tyr Thr Ile Val Phe Val Val Gly Leu Pro Ser Asn Gly Met Ala 
                85                  90                  95      


Leu Trp Val Phe Leu Phe Arg Thr Lys Lys Lys His Pro Ala Val Ile 
            100                 105                 110         


Tyr Met Ala Asn Leu Ala Leu Ala Asp Leu Leu Ser Val Ile Trp Phe 
        115                 120                 125             


Pro Leu Lys Ile Ala Tyr His Ile His Gly Asn Asn Trp Ile Tyr Gly 
    130                 135                 140                 


Glu Ala Leu Cys Asn Val Leu Ile Gly Phe Phe Tyr Gly Asn Met Tyr 
145                 150                 155                 160 


Cys Ser Ile Leu Phe Met Thr Cys Leu Ser Val Gln Arg Tyr Trp Val 
                165                 170                 175     


Ile Val Asn Pro Met Gly His Ser Arg Lys Lys Ala Asn Ile Ala Ile 
            180                 185                 190         


Gly Ile Ser Leu Ala Ile Trp Leu Leu Ile Leu Leu Val Thr Ile Pro 
        195                 200                 205             


Leu Tyr Val Val Lys Gln Thr Ile Phe Ile Pro Ala Leu Asn Ile Thr 
    210                 215                 220                 


Thr Cys His Asp Val Leu Pro Glu Gln Leu Leu Val Gly Asp Met Phe 
225                 230                 235                 240 


Asn Tyr Phe Leu Ser Leu Ala Ile Gly Val Phe Leu Phe Pro Ala Phe 
                245                 250                 255     


Leu Thr Ala Ser Ala Tyr Val Leu Met Ile Arg Met Leu Arg Ser Ser 
            260                 265                 270         


Ala Met Asp Glu Asn Ser Glu Lys Lys Arg Lys Arg Ala Ile Lys Leu 
        275                 280                 285             


Ile Val Thr Val Leu Ala Met Tyr Leu Ile Cys Phe Thr Pro Ser Asn 
    290                 295                 300                 


Leu Leu Leu Val Val His Tyr Phe Leu Ile Lys Ser Gln Gly Gln Ser 
305                 310                 315                 320 


His Val Tyr Ala Leu Tyr Ile Val Ala Leu Cys Leu Ser Thr Leu Asn 
                325                 330                 335     


Ser Cys Ile Asp Pro Phe Val Tyr Tyr Phe Val Ser His Asp Phe Arg 
            340                 345                 350         


Asp His Ala Lys Asn Ala Leu Leu Cys Arg Ser Val Arg Thr Val Lys 
        355                 360                 365             


Gln Met Gln Val Ser Leu Thr Ser Lys Lys His Ser Arg Lys Ser Ser 
    370                 375                 380                 


Ser Tyr Ser Ser Ser Ser Thr Thr Val Lys Thr Ser Tyr 
385                 390                 395         


<210>  58
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAR2 agonist


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Leucine with an amine group chemical modification

<400>  58

Ser Leu Ile Gly Arg Leu 
1               5       


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAR2 agonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Leucine with a 2-furoyl chemical modification

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Leucine with an amine group chemical modification

<400>  59

Leu Ile Gly Arg Leu 
1               5   


