               SEQUENCE LISTING

<110> PhagoMed Biopharma GmbH

<120> Novel Gardnerella endolysins and uses thereof

<130> AC1230 PCT S3

<150> EP19 17 3389.8
<151> 2019-05-08

<160> 97

<170> BiSSAP 1.3.6

<210> 1
<211> 196
<212> PRT
<213> Artificial Sequence


<220> 
<223> H1

<400> 1
Met Ser Lys Lys Gly Ile Asp Val Ser Glu Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Ala Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Gly Phe Glu Ala Ala Glu Glu Ala Gln Ser Leu Met Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Asn Lys Leu Glu Ala Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Thr Ala Asn Asn Leu Val Ser Ala His Val Arg 
    130                 135                 140                 
Asn Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Asn Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Asn Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys 
        195     

<210> 2
<211> 196
<212> PRT
<213> Artificial Sequence


<220> 
<223> H2

<400> 2
Met Ser Lys Arg Gly Ile Asp Val Ser Glu Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Cys Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Gly Phe Glu Ala Ala Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Gly Phe Cys Asn Lys Leu Glu Ser Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Thr Ala Asn Asn Leu Val Ser Ala His Val Arg 
    130                 135                 140                 
Asn Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Ser Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys 
        195     

<210> 3
<211> 196
<212> PRT
<213> Artificial Sequence


<220> 
<223> H3

<400> 3
Met Ser Lys Lys Gly Ile Asp Val Ser Val Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ser Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly His Lys Asp Lys Trp Phe Glu Glu Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Ala Gly Leu Asp Val Gly Ser Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Ser Ser Ala Gly Glu Ala Ser Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Ile Leu Ser Gly Lys Ser Phe Glu Tyr Pro Ile Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Asp Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Asn Lys Leu Glu Ala Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Val Ala Asn Asn Leu Val Ser Ser His Val Arg 
    130                 135                 140                 
Asp Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Ser Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Asn 
                165                 170                 175     
Gly Ile Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Val Ile Lys 
        195     

<210> 4
<211> 196
<212> PRT
<213> Artificial Sequence


<220> 
<223> H4

<400> 4
Met Ser Lys Lys Gly Ile Asp Val Ser Glu Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Cys Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Gly Phe Glu Ala Ala Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Ser Lys Leu Glu Thr Tyr Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Val Val Asn Asn Leu Val Ser Ala His Val Arg 
    130                 135                 140                 
Asp Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Ser Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys 
        195     

<210> 5
<211> 196
<212> PRT
<213> Artificial Sequence


<220> 
<223> H5

<400> 5
Met Ser Lys Lys Gly Ile Asp Val Ser Glu Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Ala Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Ser Ser Glu Ala Ala Glu Glu Ala Gln Ser Cys Ala Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Gly Phe Cys Ser Lys Leu Glu Ala Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Thr Ala Asn Asn Leu Val Ser Ala His Val Arg 
    130                 135                 140                 
Asn Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Ser Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Asn Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Lys Asp Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys 
        195     

<210> 6
<211> 196
<212> PRT
<213> Artificial Sequence


<220> 
<223> H6

<400> 6
Met Ser Lys Lys Gly Ile Asp Val Ser Val Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Cys Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Gly Phe Glu Ala Ala Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Ser Lys Leu Glu Ser Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Thr Ala Asn Asn Leu Val Ser Ala His Val Arg 
    130                 135                 140                 
Asn Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Asp Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Lys Asn Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys 
        195     

<210> 7
<211> 196
<212> PRT
<213> Artificial Sequence


<220> 
<223> H7

<400> 7
Met Ser Lys Lys Gly Ile Asp Val Ser Glu Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Ala Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Ala Ser Glu Ala Ala Glu Glu Ala Gln Ser Cys Ala Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Ser Lys Leu Glu Thr Tyr Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Thr Ala Asn Asn Leu Val Ser Ser His Val Arg 
    130                 135                 140                 
Asn Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Ser Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Lys Asp Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys 
        195     

<210> 8
<211> 306
<212> PRT
<213> Artificial Sequence


<220> 
<223> EL8

<400> 8
Met Ser Lys Lys Gly Ile Asp Val Ser Glu Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Ala Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Ser Ser Glu Ala Ala Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Ser Lys Leu Glu Thr Tyr Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Thr Ala Asn Asn Leu Val Ser Ser His Val Arg 
    130                 135                 140                 
Asn Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Ser Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Asn Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys Asn Ala Gly Leu Asn Gly Tyr Lys Asn Gly Gly Ser 
        195                 200                 205             
Tyr Thr Ala Pro Gln Thr Ser Ser Ile Asp Asp Val Ala Arg Glu Val 
    210                 215                 220                 
Ile Asn Gly Ala Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu Thr 
225                 230                 235                 240 
Gln Ala Gly Tyr Asp Tyr Thr Ser Val Gln Asn Lys Val Asn Lys Leu 
                245                 250                 255     
Leu Gly Val Lys Ala Cys Arg Lys Ser Val Asp Glu Leu Ala Arg Glu 
            260                 265                 270         
Val Ile Arg Gly Thr Trp Gly Asn Gly Asn Glu Arg Lys Asn Arg Leu 
        275                 280                 285             
Thr Gln Ala Gly Tyr Asp Tyr Asp Thr Val Gln Lys Arg Val Asn Glu 
    290                 295                 300                 
Leu Leu 
305     

<210> 9
<211> 251
<212> PRT
<213> Artificial Sequence


<220> 
<223> EL9

<400> 9
Met Ser Lys Lys Gly Ile Asp Val Ser Glu Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Cys Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Gly Phe Glu Ala Ala Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Val Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Asn Lys Leu Glu Ala Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Thr Ala Asn Asn Leu Val Ser Ser His Val Arg 
    130                 135                 140                 
Asn Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Asp Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys Asn Ala Gly Leu Asn Gly Cys Lys Asn Gly Gly Ser 
        195                 200                 205             
Asp Gln Ala Ala Arg Thr Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
    210                 215                 220                 
Ile Asn Gly Ala Trp Gly Asn Gly Ser Thr Arg Lys Gln Arg Leu Thr 
225                 230                 235                 240 
Ser Ala Gly Tyr Asp Tyr Ala Ser Val Ala Lys 
                245                 250     

<210> 10
<211> 196
<212> PRT
<213> Artificial Sequence


<220> 
<223> H10

<400> 10
Met Ser Lys Arg Gly Ile Asp Val Ser Val Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly His Lys Asp Lys Trp Phe Glu Glu Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Val Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Ser Ser Ala Gly Glu Ala Ser Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Ile Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Asp Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Asn Lys Leu Glu Ala Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Val Ala Asn Asn Leu Val Ser Ser His Val Arg 
    130                 135                 140                 
Asp Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Ser Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Asn 
                165                 170                 175     
Gly Ile Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Val Ile Lys 
        195     

<210> 11
<211> 196
<212> PRT
<213> Artificial Sequence


<220> 
<223> H11

<400> 11
Met Ser Lys Arg Gly Ile Asp Val Ser Val Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly His Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Thr Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Ser Ser Ala Gly Glu Ala Ala Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Ile Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Asp Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Asn Lys Leu Glu Thr Tyr Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Val Ala Asn Asn Leu Val Ser Ser His Val Arg 
    130                 135                 140                 
Asp Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Asp Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Asp 
                165                 170                 175     
Gly Ile Ala Gly Arg Val Asp Met Asp Tyr Thr Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Val Ile Lys 
        195     

<210> 12
<211> 196
<212> PRT
<213> Artificial Sequence


<220> 
<223> H12

<400> 12
Met Ser Lys Lys Gly Ile Asp Val Ser Val Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly His Lys Asp Lys Trp Phe Glu Glu Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Ala Gly Leu Asp Val Gly Ser Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Ser Ser Ala Gly Glu Val Ala Leu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Ile Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Asp Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Asn Lys Leu Glu Ala Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Val Ala Asn Asn Leu Val Ser Ser His Val Arg 
    130                 135                 140                 
Asp Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Ser Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Asn 
                165                 170                 175     
Gly Ile Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Val Ile Lys 
        195     

<210> 13
<211> 306
<212> PRT
<213> Artificial Sequence


<220> 
<223> EL13

<400> 13
Met Ser Lys Lys Gly Ile Asp Val Ser Val Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Glu Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Ala Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Gly Phe Glu Ala Ala Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Asn Lys Leu Glu Ser Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Thr Ala Asn Asn Leu Val Pro Ala His Val Arg 
    130                 135                 140                 
Asn Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Asp Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys Asn Ala Gly Leu Asn Gly Tyr Lys Asn Gly Glu Ser 
        195                 200                 205             
His Gln Ala Thr Arg Thr Thr Ser Ile Asp Glu Val Ala Arg Glu Val 
    210                 215                 220                 
Ile Asn Gly Ala Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu Thr 
225                 230                 235                 240 
Gln Ala Gly Tyr Asp Tyr Ala Ser Val Gln Asn Lys Val Asn Glu Leu 
                245                 250                 255     
Leu Gly Val Lys Ala Cys Arg Lys Ser Val Asp Glu Leu Ala Arg Glu 
            260                 265                 270         
Val Ile Arg Gly Thr Trp Gly Asn Gly Asn Glu Arg Lys Asn Arg Leu 
        275                 280                 285             
Thr Ser Ala Gly Tyr Asp Tyr Asp Thr Val Gln Lys Arg Val Asn Glu 
    290                 295                 300                 
Leu Leu 
305     

<210> 14
<211> 306
<212> PRT
<213> Artificial Sequence


<220> 
<223> EL14

<400> 14
Met Ser Lys Lys Gly Ile Asp Val Ser Val Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Cys Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Gly Phe Glu Ala Ala Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Asn Lys Leu Glu Ala Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Thr Ala Asn Asn Leu Val Ser Ala His Val Arg 
    130                 135                 140                 
Asn Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Ser Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys Asn Ala Gly Leu Asn Gly Tyr Lys Asn Gly Glu Ser 
        195                 200                 205             
His Gln Ala Thr Arg Thr Thr Ser Ile Asp Glu Val Ala Arg Glu Val 
    210                 215                 220                 
Ile Asn Gly Ala Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu Thr 
225                 230                 235                 240 
Ser Ala Gly Tyr Asp Tyr Ala Ser Val Gln Asn Lys Val Asn Glu Leu 
                245                 250                 255     
Leu Gly Val Lys Ala Cys Arg Lys Ser Val Asp Glu Leu Ala Arg Glu 
            260                 265                 270         
Val Ile Arg Gly Ala Trp Gly Asn Gly Ser Thr Arg Lys Gln Arg Leu 
        275                 280                 285             
Thr Ser Ala Gly Tyr Asp Tyr Asp Thr Val Gln Lys Arg Val Asn Glu 
    290                 295                 300                 
Leu Leu 
305     

<210> 15
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1_N

<400> 15
Asp Gln Ala Ala Arg Thr Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
1               5                   10                  15      
Ile Asn Gly Ala Trp Gly Asn Gly Ser Thr Arg Lys Gln Arg Leu Thr 
            20                  25                  30          
Ser Ala Gly Tyr Asp Tyr Ala Ser Val Gln Asn Lys Val Asn Glu Leu 
        35                  40                  45              
Leu 
    

<210> 16
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1_C

<400> 16
Gly Val Lys Ala Cys Arg Lys Ser Val Asp Glu Leu Ala Arg Glu Val 
1               5                   10                  15      
Ile Arg Gly Ala Trp Gly Asn Gly Ser Thr Arg Lys Gln Arg Leu Ala 
            20                  25                  30          
Gln Ala Gly Tyr Asp Tyr Asp Thr Val Gln Lys Arg Val Asn Glu Leu 
        35                  40                  45              
Leu 
    

<210> 17
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> B2_N

<400> 17
Asp Gln Ala Ala Arg Thr Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
1               5                   10                  15      
Ile Asn Gly Ala Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu Thr 
            20                  25                  30          
Ser Ala Gly Tyr Asp Tyr Ala Ser Val Gln Asn Lys Val Asn Glu Leu 
        35                  40                  45              
Leu 
    

<210> 18
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> B2_C

<400> 18
Gly Val Lys Ala Cys Arg Lys Ser Val Asp Glu Ile Ala Arg Glu Val 
1               5                   10                  15      
Ile Arg Gly Thr Trp Gly Asn Gly Ser Thr Arg Lys Gln Arg Leu Thr 
            20                  25                  30          
Gln Ala Gly Tyr Asp Tyr Asp Thr Val Gln Lys Arg Val Asn Glu Leu 
        35                  40                  45              
Leu 
    

<210> 19
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> B3_N

<400> 19
Tyr Thr Ala Pro Gln Thr Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
1               5                   10                  15      
Ile Asn Gly Asp Trp Gly Asn Gly Asn Asp Arg Lys Asn Arg Leu Ile 
            20                  25                  30          
Ser Ala Gly Tyr Asp Tyr Ala Ser Val Gln Asn Lys Val Asn Glu Leu 
        35                  40                  45              
Leu 
    

<210> 20
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> B3_C

<400> 20
Gly Val Lys Ala Tyr Arg Lys Ser Val Asp Glu Leu Ala Arg Glu Val 
1               5                   10                  15      
Ile Arg Gly Thr Trp Gly Asn Gly Ser Met Arg Lys His Arg Leu Thr 
            20                  25                  30          
Gln Ala Gly Tyr Asp Tyr Asp Ala Val Gln Lys Arg Val Asn Glu Leu 
        35                  40                  45              
Leu 
    

<210> 21
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> B4_N

<400> 21
Asp Gln Ala Thr Arg Thr Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
1               5                   10                  15      
Ile Asn Gly Ala Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu Thr 
            20                  25                  30          
Ser Ala Gly Tyr Asp Tyr Ala Ser Val Gln Asn Lys Val Asn Lys Leu 
        35                  40                  45              
Leu 
    

<210> 22
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> B4_C

<400> 22
Gly Val Lys Ala Tyr Arg Lys Ser Val Asp Glu Leu Ala Arg Glu Val 
1               5                   10                  15      
Ile Arg Gly Thr Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu Ala 
            20                  25                  30          
Gln Ala Gly Tyr Asp Tyr Asp Thr Val Gln Lys Arg Val Asn Glu Leu 
        35                  40                  45              
Leu 
    

<210> 23
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> B5_N

<400> 23
Asp Gln Ala Ala Arg Thr Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
1               5                   10                  15      
Ile Asn Gly Ala Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu Thr 
            20                  25                  30          
Gln Ala Gly Tyr Asp Tyr Thr Ser Val Gln Asn Lys Val Asn Lys Leu 
        35                  40                  45              
Leu 
    

<210> 24
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> B5_C

<400> 24
Gly Val Lys Ala Cys Arg Lys Ser Val Asp Glu Leu Ala Arg Glu Val 
1               5                   10                  15      
Ile Arg Gly Thr Trp Gly Asn Gly Asn Glu Arg Lys Asn Arg Leu Thr 
            20                  25                  30          
Gln Ala Gly Tyr Asp Tyr Asp Thr Val Gln Lys Arg Val Asn Glu Leu 
        35                  40                  45              
Leu 
    

<210> 25
<211> 43
<212> PRT
<213> Artificial Sequence


<220> 
<223> B6_N

<400> 25
Asn Gln Ala Ala Arg Thr Ser Ser Ile Asp Asp Val Ala Arg Glu Val 
1               5                   10                  15      
Ile Asn Gly Ala Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu Thr 
            20                  25                  30          
Gln Ala Gly Tyr Asp Tyr Ala Ser Val Ala Lys 
        35                  40              

<210> 26
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> B7_N

<400> 26
Asp Gln Ala Ala Arg Thr Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
1               5                   10                  15      
Ile Asn Gly Ala Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu Thr 
            20                  25                  30          
Gln Ala Gly Tyr Asp Tyr Thr Ser Val Gln Asn Lys Val Asn Lys Leu 
        35                  40                  45              
Leu 
    

<210> 27
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> B7_C

<400> 27
Gly Val Lys Ala Cys Arg Lys Ser Val Asp Glu Leu Ala Arg Glu Val 
1               5                   10                  15      
Ile Arg Gly Thr Trp Gly Asn Gly Asn Glu Arg Lys Asn Arg Leu Thr 
            20                  25                  30          
Gln Ala Gly Tyr Asp Tyr Asp Thr Val Gln Lys Arg Val Asn Glu Leu 
        35                  40                  45              
Leu 
    

<210> 28
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> B10_N

<400> 28
Tyr Thr Ala Pro Gln Ile Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
1               5                   10                  15      
Ile Asn Gly Asp Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu Thr 
            20                  25                  30          
Ser Ala Gly Tyr Asp Tyr Ala Ser Val Gln Asn Lys Val Asn Glu Leu 
        35                  40                  45              
Leu 
    

<210> 29
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> B10_C

<400> 29
Gly Val Lys Ala Tyr Arg Lys Ser Val Asp Glu Leu Ala Arg Glu Val 
1               5                   10                  15      
Ile Arg Gly Thr Trp Gly Asn Gly Ser Thr Arg Lys Gln Arg Leu Thr 
            20                  25                  30          
Gln Ala Gly Tyr Asp Tyr Asn Ala Val Gln Lys Arg Val Asn Glu Leu 
        35                  40                  45              
Leu 
    

<210> 30
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> B11_N

<400> 30
Tyr Thr Ala Pro Gln Thr Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
1               5                   10                  15      
Ile Asn Gly Asp Trp Gly Asn Gly Asn Glu Arg Lys Asn Arg Leu Thr 
            20                  25                  30          
Ser Ala Gly Tyr Asp Tyr Thr Ser Val Gln Asn Lys Val Asn Glu Leu 
        35                  40                  45              
Leu 
    

<210> 31
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> B11_C

<400> 31
Gly Val Lys Ala Tyr Arg Lys Ser Val Asp Glu Leu Ala Arg Glu Val 
1               5                   10                  15      
Ile Arg Gly Thr Trp Gly Asn Gly Ser Thr Arg Lys Gln Arg Leu Thr 
            20                  25                  30          
Gln Ala Gly Tyr Asp Tyr Asp Ala Val Gln Lys Arg Val Asn Glu Leu 
        35                  40                  45              
Leu 
    

<210> 32
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> B12_N

<400> 32
Tyr Thr Ala Pro Gln Thr Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
1               5                   10                  15      
Ile Asn Gly Asp Trp Gly Asn Gly Ile Glu Arg Lys Asn Arg Leu Thr 
            20                  25                  30          
Ser Ala Gly Tyr Asp Tyr Thr Ser Val Gln Asn Lys Val Asn Glu Leu 
        35                  40                  45              
Leu 
    

<210> 33
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> B12_C

<400> 33
Gly Val Lys Ala Tyr Arg Lys Ser Val Asp Glu Leu Ala Arg Glu Val 
1               5                   10                  15      
Ile Arg Gly Thr Trp Gly Asn Gly Lys Thr Arg Lys Gln Arg Leu Thr 
            20                  25                  30          
Gln Ala Gly Tyr Asp Tyr Asn Ala Val Gln Lys Arg Val Asn Glu Leu 
        35                  40                  45              
Leu 
    

<210> 34
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker polypeptide

<220> 
<221> VARIANT
<222> 1
<223> Asn = Lys

<220> 
<221> VARIANT
<222> 8
<223> Xaa = Lys or Gln

<400> 34
Asn Ala Gly Leu Asn Gly Tyr Xaa Asn Gly Gly Ser 
1               5                   10          

<210> 35
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<220> 
<221> VARIANT
<222> 1..6
<223> Xaa = Gly, Ala or Ser

<400> 35
Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       

<210> 36
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<220> 
<221> VARIANT
<222> 1..9
<223> Xaa = Gly, Ala or Ser

<400> 36
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   

<210> 37
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<220> 
<221> VARIANT
<222> 1..12
<223> Xaa = Gly, Ala or Ser

<400> 37
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10          

<210> 38
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<220> 
<221> VARIANT
<222> 1..15
<223> Xaa = Gly, Ala or Ser

<400> 38
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15  

<210> 39
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<220> 
<221> VARIANT
<222> 1..18
<223> Xaa = Gly, Ala or Ser

<400> 39
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      
Xaa Xaa 
        

<210> 40
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 40
Gly Gly Ser Gly Gly Ser 
1               5       

<210> 41
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 41
Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   

<210> 42
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 42
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10          

<210> 43
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 43
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15  

<210> 44
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 44
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      
Gly Ser 
        

<210> 45
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 45
Asn Ala Gly Leu Asn Gly Tyr Lys Asn Gly Gly Ser 
1               5                   10          

<210> 46
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<220> 
<221> VARIANT
<222> 1
<223> Xaa = Asn or Lys

<220> 
<221> VARIANT
<222> 2
<223> Xaa = Ala or Val

<220> 
<221> VARIANT
<222> 7
<223> Xaa = Tyr or Cys

<220> 
<221> VARIANT
<222> 8
<223> Xaa = Lys or Gln

<400> 46
Xaa Xaa Gly Leu Asn Gly Xaa Xaa Asn Gly Gly Ser 
1               5                   10          

<210> 47
<211> 39
<212> PRT
<213> Artificial Sequence


<220> 
<223> CW_7 motif

<220> 
<221> VARIANT
<222> 38
<223> Xaa is Ile for motif No. 1 and No. 2
      Xaa is Leu for motif No. 3

<400> 47
Thr Val Ala Asn Glu Val Ile Gln Gly Leu Trp Gly Asn Gly Gln Glu 
1               5                   10                  15      
Arg Tyr Asp Ser Leu Ala Asn Ala Gly Tyr Asp Pro Gln Ala Val Gln 
            20                  25                  30          
Asp Lys Val Asn Glu Xaa Leu 
        35                  

<210> 48
<211> 42
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer T7casette-16-rev

<400> 48
aacaggtctc aatacaatcc ggatatagtt cctcctttca gc                        42


<210> 49
<211> 43
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer T7casette-01-for

<400> 49
aacaggtctc aacctccgcg aaattaatac gactcactat agg                       43


<210> 50
<211> 37
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer EL_H1-rev

<400> 50
aacaggtctc aagccggcat ttttgatgat gctcggg                              37


<210> 51
<211> 43
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer EL_H2-rev

<400> 51
aacaggtctc aagccaacat ttttaataat gctcggataa tcc                       43


<210> 52
<211> 37
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer EL_H3-rev

<400> 52
aacaggtctc aagccggcgt ttttgataac gctcggg                              37


<210> 53
<211> 36
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer EL_H4-rev

<400> 53
aacaggtctc aagcccacgt tcttgatgat gctcgg                               36


<210> 54
<211> 36
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer EL_H5-rev

<400> 54
aacaggtctc aagccggcgt ttttgatgat gctcgg                               36


<210> 55
<211> 39
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer EL_H6-rev

<400> 55
aacaggtctc aagccggcat tcttaataat gctcggata                            39


<210> 56
<211> 42
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer EL_H7-rev

<400> 56
aacaggtctc aagccggcgt ttttaatgat gctcggataa tc                        42


<210> 57
<211> 36
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer EL_H10-rev

<400> 57
aacaggtctc aagccggcgt ttttgatcac gctcgg                               36


<210> 58
<211> 42
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer EL_H11-rev

<400> 58
aacaggtctc aagccggcct tcttgataac gctcggataa tc                        42


<210> 59
<211> 36
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer EL_H12-rev

<400> 59
aacaggtctc aagccggcat tcttgatcac gctcgg                               36


<210> 60
<211> 37
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer EL_B6-for

<400> 60
aacaggtctc aggcttaaac ggctgcaaaa atggcgg                              37


<210> 61
<211> 37
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer EL_B7-for

<400> 61
aacaggtctc aggcttaaac ggctgcaaaa acggtgg                              37


<210> 62
<211> 38
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer EL_B10-for

<400> 62
aacaggtctc aggcttaaac ggctataaaa acggcggc                             38


<210> 63
<211> 40
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer EL_B11-for

<400> 63
aacaggtctc aggcttaaat ggttacaaga atggcggcag                           40


<210> 64
<211> 37
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer EL_B12-for

<400> 64
aacaggtctc aggcttaaat ggctaccaga acggcgg                              37


<210> 65
<211> 37
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer EL_B1-for

<400> 65
aacaggtctc aggcttaaac ggctgcaaga atggtgg                              37


<210> 66
<211> 37
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer EL_B2-for

<400> 66
aacaggtctc aggcttaaat ggttgcaaga acggcgg                              37


<210> 67
<211> 38
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer EL_B3-for

<400> 67
aacaggtctc aggcttaaat ggctaccaga atggcggc                             38


<210> 68
<211> 38
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer EL_B4-for

<400> 68
aacaggtctc aggcttaaat ggctgcaaaa acggtggc                             38


<210> 69
<211> 37
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer T7term-STOP-for

<400> 69
aacaggtctc atgacgccat taacctgatg ttctggg                              37


<210> 70
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker region L10

<400> 70
Asn Ala Gly Leu Asn Gly Tyr Lys Asn Gly Gly Ser 
1               5                   10          

<210> 71
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus of B-domains

<400> 71
Val Asn Glu Leu Leu 
1               5   

<210> 72
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus of B-domains

<400> 72
Val Asn Lys Leu Leu 
1               5   

<210> 73
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus of CW_7 motifs

<400> 73
Val Asn Glu Ile Leu 
1               5   

<210> 74
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> L1

<400> 74
Asn Ala Gly Leu Asn Gly Cys Lys Asn Gly Gly Ser 
1               5                   10          

<210> 75
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> L2

<400> 75
Asn Val Gly Leu Asn Gly Cys Lys Asn Gly Gly Ser 
1               5                   10          

<210> 76
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> L3

<400> 76
Asn Ala Gly Leu Asn Gly Tyr Gln Asn Gly Gly Ser 
1               5                   10          

<210> 77
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> L4

<400> 77
Asn Val Gly Leu Asn Gly Cys Lys Asn Gly Gly Ser 
1               5                   10          

<210> 78
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> L5

<400> 78
Asn Ala Gly Leu Asn Gly Cys Lys Asn Gly Gly Ser 
1               5                   10          

<210> 79
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> L6

<400> 79
Asn Ala Gly Leu Asn Gly Cys Lys Asn Gly Gly Ser 
1               5                   10          

<210> 80
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> L7

<400> 80
Asn Ala Gly Leu Asn Gly Cys Lys Asn Gly Gly Ser 
1               5                   10          

<210> 81
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> L10

<400> 81
Asn Ala Gly Leu Asn Gly Tyr Lys Asn Gly Gly Ser 
1               5                   10          

<210> 82
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> L11

<400> 82
Lys Ala Gly Leu Asn Gly Tyr Lys Asn Gly Gly Ser 
1               5                   10          

<210> 83
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> L12

<400> 83
Asn Ala Gly Leu Asn Gly Tyr Gln Asn Gly Gly Ser 
1               5                   10          

<210> 84
<211> 306
<212> PRT
<213> Artificial Sequence


<220> 
<223> EL11_strain_JCP8017A

<400> 84
Met Ser Lys Arg Gly Ile Asp Val Ser Val Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly His Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Thr Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Ser Ser Ala Gly Glu Ala Ala Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Ile Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Asp Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Asn Lys Leu Glu Thr Tyr Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Val Ala Asn Asn Leu Val Ser Ser His Val Arg 
    130                 135                 140                 
Asp Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Asp Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Asp 
                165                 170                 175     
Gly Ile Ala Gly Arg Val Asp Met Asp Tyr Thr Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Val Ile Lys Lys Ala Gly Leu Asn Gly Tyr Lys Asn Gly Gly Ser 
        195                 200                 205             
Tyr Thr Ala Pro Gln Thr Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
    210                 215                 220                 
Ile Asn Gly Asp Trp Gly Asn Gly Asn Glu Arg Lys Asn Arg Leu Thr 
225                 230                 235                 240 
Ser Ala Gly Tyr Asp Tyr Thr Ser Val Gln Asn Lys Val Asn Glu Leu 
                245                 250                 255     
Leu Gly Val Lys Ala Tyr Arg Lys Ser Val Asp Glu Leu Ala Arg Glu 
            260                 265                 270         
Val Ile Arg Gly Thr Trp Gly Asn Gly Ser Thr Arg Lys Gln Arg Leu 
        275                 280                 285             
Thr Gln Ala Gly Tyr Asp Tyr Asp Ala Val Gln Lys Arg Val Asn Glu 
    290                 295                 300                 
Leu Leu 
305     

<210> 85
<211> 306
<212> PRT
<213> Artificial Sequence


<220> 
<223> EL3_strain_Gv18-4

<400> 85
Met Ser Lys Lys Gly Ile Asp Val Ser Val Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ser Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly His Lys Asp Lys Trp Phe Glu Glu Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Ala Gly Leu Asp Val Gly Ser Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Ser Ser Ala Gly Glu Ala Ser Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Ile Leu Ser Gly Lys Ser Phe Glu Tyr Pro Ile Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Asp Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Asn Lys Leu Glu Ala Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Val Ala Asn Asn Leu Val Ser Ser His Val Arg 
    130                 135                 140                 
Asp Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Ser Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Asn 
                165                 170                 175     
Gly Ile Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Val Ile Lys Asn Ala Gly Leu Asn Gly Tyr Gln Asn Gly Gly Ser 
        195                 200                 205             
Tyr Thr Ala Pro Gln Thr Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
    210                 215                 220                 
Ile Asn Gly Asp Trp Gly Asn Gly Asn Asp Arg Lys Asn Arg Leu Ile 
225                 230                 235                 240 
Ser Ala Gly Tyr Asp Tyr Ala Ser Val Gln Asn Lys Val Asn Glu Leu 
                245                 250                 255     
Leu Gly Val Lys Ala Tyr Arg Lys Ser Val Asp Glu Leu Ala Arg Glu 
            260                 265                 270         
Val Ile Arg Gly Thr Trp Gly Asn Gly Ser Met Arg Lys His Arg Leu 
        275                 280                 285             
Thr Gln Ala Gly Tyr Asp Tyr Asp Ala Val Gln Lys Arg Val Asn Glu 
    290                 295                 300                 
Leu Leu 
305     

<210> 86
<211> 306
<212> PRT
<213> Artificial Sequence


<220> 
<223> EL10_strain_G30-4

<400> 86
Met Ser Lys Arg Gly Ile Asp Val Ser Val Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly His Lys Asp Lys Trp Phe Glu Glu Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Val Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Ser Ser Ala Gly Glu Ala Ser Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Ile Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Asp Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Asn Lys Leu Glu Ala Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Val Ala Asn Asn Leu Val Ser Ser His Val Arg 
    130                 135                 140                 
Asp Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Ser Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Asn 
                165                 170                 175     
Gly Ile Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Val Ile Lys Asn Ala Gly Leu Asn Gly Tyr Lys Asn Gly Gly Ser 
        195                 200                 205             
Tyr Thr Ala Pro Gln Ile Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
    210                 215                 220                 
Ile Asn Gly Asp Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu Thr 
225                 230                 235                 240 
Ser Ala Gly Tyr Asp Tyr Ala Ser Val Gln Asn Lys Val Asn Glu Leu 
                245                 250                 255     
Leu Gly Val Lys Ala Tyr Arg Lys Ser Val Asp Glu Leu Ala Arg Glu 
            260                 265                 270         
Val Ile Arg Gly Thr Trp Gly Asn Gly Ser Thr Arg Lys Gln Arg Leu 
        275                 280                 285             
Thr Gln Ala Gly Tyr Asp Tyr Asn Ala Val Gln Lys Arg Val Asn Glu 
    290                 295                 300                 
Leu Leu 
305     

<210> 87
<211> 306
<212> PRT
<213> Artificial Sequence


<220> 
<223> EL12_strain_3549624_non-prophage

<400> 87
Met Ser Lys Lys Gly Ile Asp Val Ser Val Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly His Lys Asp Lys Trp Phe Glu Glu Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Ala Gly Leu Asp Val Gly Ser Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Ser Ser Ala Gly Glu Val Ala Leu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Ile Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Asp Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Asn Lys Leu Glu Ala Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Val Ala Asn Asn Leu Val Ser Ser His Val Arg 
    130                 135                 140                 
Asp Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Ser Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Asn 
                165                 170                 175     
Gly Ile Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Val Ile Lys Asn Ala Gly Leu Asn Gly Tyr Gln Asn Gly Gly Ser 
        195                 200                 205             
Tyr Thr Ala Pro Gln Thr Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
    210                 215                 220                 
Ile Asn Gly Asp Trp Gly Asn Gly Ile Glu Arg Lys Asn Arg Leu Thr 
225                 230                 235                 240 
Ser Ala Gly Tyr Asp Tyr Thr Ser Val Gln Asn Lys Val Asn Glu Leu 
                245                 250                 255     
Leu Gly Val Lys Ala Tyr Arg Lys Ser Val Asp Glu Leu Ala Arg Glu 
            260                 265                 270         
Val Ile Arg Gly Thr Trp Gly Asn Gly Lys Thr Arg Lys Gln Arg Leu 
        275                 280                 285             
Thr Gln Ala Gly Tyr Asp Tyr Asn Ala Val Gln Lys Arg Val Asn Glu 
    290                 295                 300                 
Leu Leu 
305     

<210> 88
<211> 306
<212> PRT
<213> Artificial Sequence


<220> 
<223> EL8_strain_JCP7719

<400> 88
Met Ser Lys Lys Gly Ile Asp Val Ser Glu Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Ala Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Ser Ser Glu Ala Ala Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Ser Lys Leu Glu Thr Tyr Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Thr Ala Asn Asn Leu Val Ser Ser His Val Arg 
    130                 135                 140                 
Asn Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Ser Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Asn Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys Asn Ala Gly Leu Asn Gly Tyr Lys Asn Gly Gly Ser 
        195                 200                 205             
Tyr Thr Ala Pro Gln Thr Ser Ser Ile Asp Asp Val Ala Arg Glu Val 
    210                 215                 220                 
Ile Asn Gly Ala Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu Thr 
225                 230                 235                 240 
Gln Ala Gly Tyr Asp Tyr Thr Ser Val Gln Asn Lys Val Asn Lys Leu 
                245                 250                 255     
Leu Gly Val Lys Ala Cys Arg Lys Ser Val Asp Glu Leu Ala Arg Glu 
            260                 265                 270         
Val Ile Arg Gly Thr Trp Gly Asn Gly Asn Glu Arg Lys Asn Arg Leu 
        275                 280                 285             
Thr Gln Ala Gly Tyr Asp Tyr Asp Thr Val Gln Lys Arg Val Asn Glu 
    290                 295                 300                 
Leu Leu 
305     

<210> 89
<211> 306
<212> PRT
<213> Artificial Sequence


<220> 
<223> EL5_strain_JCP7276

<400> 89
Met Ser Lys Lys Gly Ile Asp Val Ser Glu Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Ala Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Ser Ser Glu Ala Ala Glu Glu Ala Gln Ser Cys Ala Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Gly Phe Cys Ser Lys Leu Glu Ala Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Thr Ala Asn Asn Leu Val Ser Ala His Val Arg 
    130                 135                 140                 
Asn Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Ser Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Asn Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Lys Asp Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys Asn Ala Gly Leu Asn Gly Cys Lys Asn Gly Gly Ser 
        195                 200                 205             
Asp Gln Ala Ala Arg Thr Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
    210                 215                 220                 
Ile Asn Gly Ala Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu Thr 
225                 230                 235                 240 
Gln Ala Gly Tyr Asp Tyr Thr Ser Val Gln Asn Lys Val Asn Lys Leu 
                245                 250                 255     
Leu Gly Val Lys Ala Cys Arg Lys Ser Val Asp Glu Leu Ala Arg Glu 
            260                 265                 270         
Val Ile Arg Gly Thr Trp Gly Asn Gly Asn Glu Arg Lys Asn Arg Leu 
        275                 280                 285             
Thr Gln Ala Gly Tyr Asp Tyr Asp Thr Val Gln Lys Arg Val Asn Glu 
    290                 295                 300                 
Leu Leu 
305     

<210> 90
<211> 306
<212> PRT
<213> Artificial Sequence


<220> 
<223> EL7_strain_AMD

<400> 90
Met Ser Lys Lys Gly Ile Asp Val Ser Glu Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Ala Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Ala Ser Glu Ala Ala Glu Glu Ala Gln Ser Cys Ala Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Ser Lys Leu Glu Thr Tyr Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Thr Ala Asn Asn Leu Val Ser Ser His Val Arg 
    130                 135                 140                 
Asn Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Ser Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Lys Asp Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys Asn Ala Gly Leu Asn Gly Cys Lys Asn Gly Gly Ser 
        195                 200                 205             
Asp Gln Ala Ala Arg Thr Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
    210                 215                 220                 
Ile Asn Gly Ala Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu Thr 
225                 230                 235                 240 
Gln Ala Gly Tyr Asp Tyr Thr Ser Val Gln Asn Lys Val Asn Lys Leu 
                245                 250                 255     
Leu Gly Val Lys Ala Cys Arg Lys Ser Val Asp Glu Leu Ala Arg Glu 
            260                 265                 270         
Val Ile Arg Gly Thr Trp Gly Asn Gly Asn Glu Arg Lys Asn Arg Leu 
        275                 280                 285             
Thr Gln Ala Gly Tyr Asp Tyr Asp Thr Val Gln Lys Arg Val Asn Glu 
    290                 295                 300                 
Leu Leu 
305     

<210> 91
<211> 306
<212> PRT
<213> Artificial Sequence


<220> 
<223> EL4_strain_Gv5-1

<400> 91
Met Ser Lys Lys Gly Ile Asp Val Ser Glu Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Cys Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Gly Phe Glu Ala Ala Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Ser Lys Leu Glu Thr Tyr Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Val Val Asn Asn Leu Val Ser Ala His Val Arg 
    130                 135                 140                 
Asp Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Ser Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys Asn Val Gly Leu Asn Gly Cys Lys Asn Gly Gly Ser 
        195                 200                 205             
Asp Gln Ala Thr Arg Thr Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
    210                 215                 220                 
Ile Asn Gly Ala Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu Thr 
225                 230                 235                 240 
Ser Ala Gly Tyr Asp Tyr Ala Ser Val Gln Asn Lys Val Asn Lys Leu 
                245                 250                 255     
Leu Gly Val Lys Ala Tyr Arg Lys Ser Val Asp Glu Leu Ala Arg Glu 
            260                 265                 270         
Val Ile Arg Gly Thr Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu 
        275                 280                 285             
Ala Gln Ala Gly Tyr Asp Tyr Asp Thr Val Gln Lys Arg Val Asn Glu 
    290                 295                 300                 
Leu Leu 
305     

<210> 92
<211> 251
<212> PRT
<213> Artificial Sequence


<220> 
<223> EL6_strain_1400E_frameshift

<400> 92
Met Ser Lys Lys Gly Ile Asp Val Ser Val Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Cys Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Gly Phe Glu Ala Ala Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Ser Lys Leu Glu Ser Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Thr Ala Asn Asn Leu Val Ser Ala His Val Arg 
    130                 135                 140                 
Asn Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Asp Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Lys Asn Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys Asn Ala Gly Leu Asn Gly Cys Lys Asn Gly Gly Ser 
        195                 200                 205             
Asn Gln Ala Ala Arg Thr Ser Ser Ile Asp Asp Val Ala Arg Glu Val 
    210                 215                 220                 
Ile Asn Gly Ala Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu Thr 
225                 230                 235                 240 
Gln Ala Gly Tyr Asp Tyr Ala Ser Val Ala Lys 
                245                 250     

<210> 93
<211> 306
<212> PRT
<213> Artificial Sequence


<220> 
<223> EL1_strain_HMP9231

<400> 93
Met Ser Lys Lys Gly Ile Asp Val Ser Glu Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Ala Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Gly Phe Glu Ala Ala Glu Glu Ala Gln Ser Leu Met Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Asn Lys Leu Glu Ala Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Thr Ala Asn Asn Leu Val Ser Ala His Val Arg 
    130                 135                 140                 
Asn Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Asn Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Asn Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys Asn Ala Gly Leu Asn Gly Cys Lys Asn Gly Gly Ser 
        195                 200                 205             
Asp Gln Ala Ala Arg Thr Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
    210                 215                 220                 
Ile Asn Gly Ala Trp Gly Asn Gly Ser Thr Arg Lys Gln Arg Leu Thr 
225                 230                 235                 240 
Ser Ala Gly Tyr Asp Tyr Ala Ser Val Gln Asn Lys Val Asn Glu Leu 
                245                 250                 255     
Leu Gly Val Lys Ala Cys Arg Lys Ser Val Asp Glu Leu Ala Arg Glu 
            260                 265                 270         
Val Ile Arg Gly Ala Trp Gly Asn Gly Ser Thr Arg Lys Gln Arg Leu 
        275                 280                 285             
Ala Gln Ala Gly Tyr Asp Tyr Asp Thr Val Gln Lys Arg Val Asn Glu 
    290                 295                 300                 
Leu Leu 
305     

<210> 94
<211> 251
<212> PRT
<213> Artificial Sequence


<220> 
<223> EL9_strain_0288E_incomplete_contig

<400> 94
Met Ser Lys Lys Gly Ile Asp Val Ser Glu Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Cys Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Gly Phe Glu Ala Ala Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Val Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Asn Lys Leu Glu Ala Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Thr Ala Asn Asn Leu Val Ser Ser His Val Arg 
    130                 135                 140                 
Asn Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Asp Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys Asn Ala Gly Leu Asn Gly Cys Lys Asn Gly Gly Ser 
        195                 200                 205             
Asp Gln Ala Ala Arg Thr Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
    210                 215                 220                 
Ile Asn Gly Ala Trp Gly Asn Gly Ser Thr Arg Lys Gln Arg Leu Thr 
225                 230                 235                 240 
Ser Ala Gly Tyr Asp Tyr Ala Ser Val Ala Lys 
                245                 250     

<210> 95
<211> 306
<212> PRT
<213> Artificial Sequence


<220> 
<223> EL2_strain_Gv18-4

<400> 95
Met Ser Lys Arg Gly Ile Asp Val Ser Glu Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Cys Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Gly Phe Glu Ala Ala Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Gly Phe Cys Asn Lys Leu Glu Ser Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Thr Ala Asn Asn Leu Val Ser Ala His Val Arg 
    130                 135                 140                 
Asn Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Ser Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys Asn Val Gly Leu Asn Gly Cys Lys Asn Gly Gly Ser 
        195                 200                 205             
Asp Gln Ala Ala Arg Thr Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
    210                 215                 220                 
Ile Asn Gly Ala Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu Thr 
225                 230                 235                 240 
Ser Ala Gly Tyr Asp Tyr Ala Ser Val Gln Asn Lys Val Asn Glu Leu 
                245                 250                 255     
Leu Gly Val Lys Ala Cys Arg Lys Ser Val Asp Glu Ile Ala Arg Glu 
            260                 265                 270         
Val Ile Arg Gly Thr Trp Gly Asn Gly Ser Thr Arg Lys Gln Arg Leu 
        275                 280                 285             
Thr Gln Ala Gly Tyr Asp Tyr Asp Thr Val Gln Lys Arg Val Asn Glu 
    290                 295                 300                 
Leu Leu 
305     

<210> 96
<211> 306
<212> PRT
<213> Artificial Sequence


<220> 
<223> EL13_strain_Gv37_1

<400> 96
Met Ser Lys Lys Gly Ile Asp Val Ser Val Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Glu Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Ala Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Gly Phe Glu Ala Ala Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Asn Lys Leu Glu Ser Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Thr Ala Asn Asn Leu Val Pro Ala His Val Arg 
    130                 135                 140                 
Asn Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Asp Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys Asn Ala Gly Leu Asn Gly Tyr Lys Asn Gly Glu Ser 
        195                 200                 205             
His Gln Ala Thr Arg Thr Thr Ser Ile Asp Glu Val Ala Arg Glu Val 
    210                 215                 220                 
Ile Asn Gly Ala Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu Thr 
225                 230                 235                 240 
Gln Ala Gly Tyr Asp Tyr Ala Ser Val Gln Asn Lys Val Asn Glu Leu 
                245                 250                 255     
Leu Gly Val Lys Ala Cys Arg Lys Ser Val Asp Glu Leu Ala Arg Glu 
            260                 265                 270         
Val Ile Arg Gly Thr Trp Gly Asn Gly Asn Glu Arg Lys Asn Arg Leu 
        275                 280                 285             
Thr Ser Ala Gly Tyr Asp Tyr Asp Thr Val Gln Lys Arg Val Asn Glu 
    290                 295                 300                 
Leu Leu 
305     

<210> 97
<211> 306
<212> PRT
<213> Artificial Sequence


<220> 
<223> EL14_strain_Gv37_2

<400> 97
Met Ser Lys Lys Gly Ile Asp Val Ser Val Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      
Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          
Gly Tyr Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              
Lys Ala Lys Thr Cys Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  
Ala Asn Ser Gly Phe Glu Ala Ala Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  
Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      
Glu Lys Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile 
            100                 105                 110         
Thr Ser Phe Cys Asn Lys Leu Glu Ala Cys Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             
Tyr Thr Ser Leu Ser Thr Ala Asn Asn Leu Val Ser Ala His Val Arg 
    130                 135                 140                 
Asn Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Ser Tyr 
145                 150                 155                 160 
Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Pro 
                165                 170                 175     
Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         
Ser Ile Ile Lys Asn Ala Gly Leu Asn Gly Tyr Lys Asn Gly Glu Ser 
        195                 200                 205             
His Gln Ala Thr Arg Thr Thr Ser Ile Asp Glu Val Ala Arg Glu Val 
    210                 215                 220                 
Ile Asn Gly Ala Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu Thr 
225                 230                 235                 240 
Ser Ala Gly Tyr Asp Tyr Ala Ser Val Gln Asn Lys Val Asn Glu Leu 
                245                 250                 255     
Leu Gly Val Lys Ala Cys Arg Lys Ser Val Asp Glu Leu Ala Arg Glu 
            260                 265                 270         
Val Ile Arg Gly Ala Trp Gly Asn Gly Ser Thr Arg Lys Gln Arg Leu 
        275                 280                 285             
Thr Ser Ala Gly Tyr Asp Tyr Asp Thr Val Gln Lys Arg Val Asn Glu 
    290                 295                 300                 
Leu Leu 
305     

