                         SEQUENCE LISTING

<110>  Institute of Genetics and Developmental Biology, Chinese 
       Academy of Sciences
 
<120>  Improved gene editing system

<130>  P2020TC1048

<150>  201910375061.9
<151>  2019-05-07

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  1

Lys Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  2
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn Ser Gly Ser Glu Thr Pro Gly Thr Ser 
        195                 200                 205             


Glu Ser Ala Thr Pro Glu Ser 
    210                 215 


<210>  3
<211>  228
<212>  PRT
<213>  Escherichia coli

<400>  3

Ala Asn Glu Leu Thr Trp His Asp Val Leu Ala Glu Glu Lys Gln Gln 
1               5                   10                  15      


Pro Tyr Phe Leu Asn Thr Leu Gln Thr Val Ala Ser Glu Arg Gln Ser 
            20                  25                  30          


Gly Val Thr Ile Tyr Pro Pro Gln Lys Asp Val Phe Asn Ala Phe Arg 
        35                  40                  45              


Phe Thr Glu Leu Gly Asp Val Lys Val Val Ile Leu Gly Gln Asp Pro 
    50                  55                  60                  


Tyr His Gly Pro Gly Gln Ala His Gly Leu Ala Phe Ser Val Arg Pro 
65                  70                  75                  80  


Gly Ile Ala Ile Pro Pro Ser Leu Leu Asn Met Tyr Lys Glu Leu Glu 
                85                  90                  95      


Asn Thr Ile Pro Gly Phe Thr Arg Pro Asn His Gly Tyr Leu Glu Ser 
            100                 105                 110         


Trp Ala Arg Gln Gly Val Leu Leu Leu Asn Thr Val Leu Thr Val Arg 
        115                 120                 125             


Ala Gly Gln Ala His Ser His Ala Ser Leu Gly Trp Glu Thr Phe Thr 
    130                 135                 140                 


Asp Lys Val Ile Ser Leu Ile Asn Gln His Arg Glu Gly Val Val Phe 
145                 150                 155                 160 


Leu Leu Trp Gly Ser His Ala Gln Lys Lys Gly Ala Ile Ile Asp Lys 
                165                 170                 175     


Gln Arg His His Val Leu Lys Ala Pro His Pro Ser Pro Leu Ser Ala 
            180                 185                 190         


His Arg Gly Phe Phe Gly Cys Asn His Phe Val Leu Ala Asn Gln Trp 
        195                 200                 205             


Leu Glu Gln Arg Gly Glu Thr Pro Ile Asp Trp Met Pro Val Leu Pro 
    210                 215                 220                 


Ala Glu Ser Glu 
225             


<210>  4
<211>  263
<212>  PRT
<213>  escherichia coli

<400>  4

Met Pro Glu Gly Pro Glu Ile Arg Arg Ala Ala Asp Asn Leu Glu Ala 
1               5                   10                  15      


Ala Ile Lys Gly Lys Pro Leu Thr Asp Val Trp Phe Ala Phe Pro Gln 
            20                  25                  30          


Leu Lys Pro Tyr Gln Ser Gln Leu Ile Gly Gln His Val Thr His Val 
        35                  40                  45              


Glu Thr Arg Gly Lys Ala Leu Leu Thr His Phe Ser Asn Asp Leu Thr 
    50                  55                  60                  


Leu Tyr Ser His Asn Gln Leu Tyr Gly Val Trp Arg Val Val Asp Thr 
65                  70                  75                  80  


Gly Glu Glu Pro Gln Thr Thr Arg Val Leu Arg Val Lys Leu Gln Thr 
                85                  90                  95      


Ala Asp Lys Thr Ile Leu Leu Tyr Ser Ala Ser Asp Ile Glu Met Leu 
            100                 105                 110         


Thr Pro Glu Gln Leu Thr Thr His Pro Phe Leu Gln Arg Val Gly Pro 
        115                 120                 125             


Asp Val Leu Asp Pro Asn Leu Thr Pro Glu Val Val Lys Glu Arg Leu 
    130                 135                 140                 


Leu Ser Pro Arg Phe Arg Asn Arg Gln Phe Ala Gly Leu Leu Leu Asp 
145                 150                 155                 160 


Gln Ala Phe Leu Ala Gly Leu Gly Asn Tyr Leu Arg Val Glu Ile Leu 
                165                 170                 175     


Trp Gln Val Gly Leu Thr Gly Asn His Lys Ala Lys Asp Leu Asn Ala 
            180                 185                 190         


Ala Gln Leu Asp Ala Leu Ala His Ala Leu Leu Glu Ile Pro Arg Phe 
        195                 200                 205             


Ser Tyr Ala Thr Arg Gly Gln Val Asp Glu Asn Lys His His Gly Ala 
    210                 215                 220                 


Leu Phe Arg Phe Lys Val Phe His Arg Asp Gly Glu Pro Cys Glu Arg 
225                 230                 235                 240 


Cys Gly Ser Ile Ile Glu Lys Thr Thr Leu Ser Ser Arg Pro Phe Tyr 
                245                 250                 255     


Trp Cys Pro Gly Cys Gln His 
            260             


<210>  5
<211>  1842
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary first polypeptide

<400>  5

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn Ser Gly Ser Glu Thr Pro Gly Thr Ser 
        195                 200                 205             


Glu Ser Ala Thr Pro Glu Ser Leu Lys Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1340                 1345                 1350             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1535                 1540                 1545             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Lys  Arg Pro Ala Ala Thr  Lys Lys Ala 
    1580                 1585                 1590             


Gly Gln  Ala Lys Lys Lys Lys  Thr Arg Asp Ser Gly  Gly Ser Ala 
    1595                 1600                 1605             


Asn Glu  Leu Thr Trp His Asp  Val Leu Ala Glu Glu  Lys Gln Gln 
    1610                 1615                 1620             


Pro Tyr  Phe Leu Asn Thr Leu  Gln Thr Val Ala Ser  Glu Arg Gln 
    1625                 1630                 1635             


Ser Gly  Val Thr Ile Tyr Pro  Pro Gln Lys Asp Val  Phe Asn Ala 
    1640                 1645                 1650             


Phe Arg  Phe Thr Glu Leu Gly  Asp Val Lys Val Val  Ile Leu Gly 
    1655                 1660                 1665             


Gln Asp  Pro Tyr His Gly Pro  Gly Gln Ala His Gly  Leu Ala Phe 
    1670                 1675                 1680             


Ser Val  Arg Pro Gly Ile Ala  Ile Pro Pro Ser Leu  Leu Asn Met 
    1685                 1690                 1695             


Tyr Lys  Glu Leu Glu Asn Thr  Ile Pro Gly Phe Thr  Arg Pro Asn 
    1700                 1705                 1710             


His Gly  Tyr Leu Glu Ser Trp  Ala Arg Gln Gly Val  Leu Leu Leu 
    1715                 1720                 1725             


Asn Thr  Val Leu Thr Val Arg  Ala Gly Gln Ala His  Ser His Ala 
    1730                 1735                 1740             


Ser Leu  Gly Trp Glu Thr Phe  Thr Asp Lys Val Ile  Ser Leu Ile 
    1745                 1750                 1755             


Asn Gln  His Arg Glu Gly Val  Val Phe Leu Leu Trp  Gly Ser His 
    1760                 1765                 1770             


Ala Gln  Lys Lys Gly Ala Ile  Ile Asp Lys Gln Arg  His His Val 
    1775                 1780                 1785             


Leu Lys  Ala Pro His Pro Ser  Pro Leu Ser Ala His  Arg Gly Phe 
    1790                 1795                 1800             


Phe Gly  Cys Asn His Phe Val  Leu Ala Asn Gln Trp  Leu Glu Gln 
    1805                 1810                 1815             


Arg Gly  Glu Thr Pro Ile Asp  Trp Met Pro Val Leu  Pro Ala Glu 
    1820                 1825                 1830             


Ser Glu  Pro Lys Lys Lys Arg  Lys Val 
    1835                 1840         


<210>  6
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary second polypeptide

<400>  6

Met Pro Glu Gly Pro Glu Ile Arg Arg Ala Ala Asp Asn Leu Glu Ala 
1               5                   10                  15      


Ala Ile Lys Gly Lys Pro Leu Thr Asp Val Trp Phe Ala Phe Pro Gln 
            20                  25                  30          


Leu Lys Pro Tyr Gln Ser Gln Leu Ile Gly Gln His Val Thr His Val 
        35                  40                  45              


Glu Thr Arg Gly Lys Ala Leu Leu Thr His Phe Ser Asn Asp Leu Thr 
    50                  55                  60                  


Leu Tyr Ser His Asn Gln Leu Tyr Gly Val Trp Arg Val Val Asp Thr 
65                  70                  75                  80  


Gly Glu Glu Pro Gln Thr Thr Arg Val Leu Arg Val Lys Leu Gln Thr 
                85                  90                  95      


Ala Asp Lys Thr Ile Leu Leu Tyr Ser Ala Ser Asp Ile Glu Met Leu 
            100                 105                 110         


Thr Pro Glu Gln Leu Thr Thr His Pro Phe Leu Gln Arg Val Gly Pro 
        115                 120                 125             


Asp Val Leu Asp Pro Asn Leu Thr Pro Glu Val Val Lys Glu Arg Leu 
    130                 135                 140                 


Leu Ser Pro Arg Phe Arg Asn Arg Gln Phe Ala Gly Leu Leu Leu Asp 
145                 150                 155                 160 


Gln Ala Phe Leu Ala Gly Leu Gly Asn Tyr Leu Arg Val Glu Ile Leu 
                165                 170                 175     


Trp Gln Val Gly Leu Thr Gly Asn His Lys Ala Lys Asp Leu Asn Ala 
            180                 185                 190         


Ala Gln Leu Asp Ala Leu Ala His Ala Leu Leu Glu Ile Pro Arg Phe 
        195                 200                 205             


Ser Tyr Ala Thr Arg Gly Gln Val Asp Glu Asn Lys His His Gly Ala 
    210                 215                 220                 


Leu Phe Arg Phe Lys Val Phe His Arg Asp Gly Glu Pro Cys Glu Arg 
225                 230                 235                 240 


Cys Gly Ser Ile Ile Glu Lys Thr Thr Leu Ser Ser Arg Pro Phe Tyr 
                245                 250                 255     


Trp Cys Pro Gly Cys Gln His Pro Lys Lys Lys Arg Lys Val 
            260                 265                 270 


<210>  7
<211>  197
<212>  PRT
<213>  artificial sequence

<220>
<223>  APOBEC3Bctd

<400>  7

Met Glu Ile Leu Arg Tyr Leu Met Asp Pro Asp Thr Phe Thr Phe Asn 
1               5                   10                  15      


Phe Asn Asn Asp Pro Leu Val Leu Arg Arg Arg Gln Thr Tyr Leu Cys 
            20                  25                  30          


Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Trp Val Leu Met Asp Gln 
        35                  40                  45              


His Met Gly Phe Leu Cys Asn Glu Ala Lys Asn Leu Leu Cys Gly Phe 
    50                  55                  60                  


Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro Ser Leu 
65                  70                  75                  80  


Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp 
                85                  90                  95      


Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala Phe Leu 
            100                 105                 110         


Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr 
        115                 120                 125             


Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg Asp Ala 
    130                 135                 140                 


Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Glu Tyr Cys Trp 
145                 150                 155                 160 


Asp Thr Phe Val Tyr Arg Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly 
                165                 170                 175     


Leu Glu Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu 
            180                 185                 190         


Gln Asn Gln Gly Asn 
        195         


<210>  8
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  XTEN linker

<400>  8

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210>  9
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  P2A

<400>  9

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro Pro Glu 
            20                  


<210>  10
<211>  2135
<212>  PRT
<213>  artificial sequence

<220>
<223>  AFID-3

<400>  10

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn Ser Gly Ser Glu Thr Pro Gly Thr Ser 
        195                 200                 205             


Glu Ser Ala Thr Pro Glu Ser Leu Lys Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1340                 1345                 1350             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1535                 1540                 1545             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Lys  Arg Pro Ala Ala Thr  Lys Lys Ala 
    1580                 1585                 1590             


Gly Gln  Ala Lys Lys Lys Lys  Thr Arg Asp Ser Gly  Gly Ser Ala 
    1595                 1600                 1605             


Asn Glu  Leu Thr Trp His Asp  Val Leu Ala Glu Glu  Lys Gln Gln 
    1610                 1615                 1620             


Pro Tyr  Phe Leu Asn Thr Leu  Gln Thr Val Ala Ser  Glu Arg Gln 
    1625                 1630                 1635             


Ser Gly  Val Thr Ile Tyr Pro  Pro Gln Lys Asp Val  Phe Asn Ala 
    1640                 1645                 1650             


Phe Arg  Phe Thr Glu Leu Gly  Asp Val Lys Val Val  Ile Leu Gly 
    1655                 1660                 1665             


Gln Asp  Pro Tyr His Gly Pro  Gly Gln Ala His Gly  Leu Ala Phe 
    1670                 1675                 1680             


Ser Val  Arg Pro Gly Ile Ala  Ile Pro Pro Ser Leu  Leu Asn Met 
    1685                 1690                 1695             


Tyr Lys  Glu Leu Glu Asn Thr  Ile Pro Gly Phe Thr  Arg Pro Asn 
    1700                 1705                 1710             


His Gly  Tyr Leu Glu Ser Trp  Ala Arg Gln Gly Val  Leu Leu Leu 
    1715                 1720                 1725             


Asn Thr  Val Leu Thr Val Arg  Ala Gly Gln Ala His  Ser His Ala 
    1730                 1735                 1740             


Ser Leu  Gly Trp Glu Thr Phe  Thr Asp Lys Val Ile  Ser Leu Ile 
    1745                 1750                 1755             


Asn Gln  His Arg Glu Gly Val  Val Phe Leu Leu Trp  Gly Ser His 
    1760                 1765                 1770             


Ala Gln  Lys Lys Gly Ala Ile  Ile Asp Lys Gln Arg  His His Val 
    1775                 1780                 1785             


Leu Lys  Ala Pro His Pro Ser  Pro Leu Ser Ala His  Arg Gly Phe 
    1790                 1795                 1800             


Phe Gly  Cys Asn His Phe Val  Leu Ala Asn Gln Trp  Leu Glu Gln 
    1805                 1810                 1815             


Arg Gly  Glu Thr Pro Ile Asp  Trp Met Pro Val Leu  Pro Ala Glu 
    1820                 1825                 1830             


Ser Glu  Pro Lys Lys Lys Arg  Lys Val Ser Ala Gly  Ser Gly Ala 
    1835                 1840                 1845             


Thr Asn  Phe Ser Leu Leu Lys  Gln Ala Gly Asp Val  Glu Glu Asn 
    1850                 1855                 1860             


Pro Gly  Pro Pro Glu Gly Pro  Glu Ile Arg Arg Ala  Ala Asp Asn 
    1865                 1870                 1875             


Leu Glu  Ala Ala Ile Lys Gly  Lys Pro Leu Thr Asp  Val Trp Phe 
    1880                 1885                 1890             


Ala Phe  Pro Gln Leu Lys Pro  Tyr Gln Ser Gln Leu  Ile Gly Gln 
    1895                 1900                 1905             


His Val  Thr His Val Glu Thr  Arg Gly Lys Ala Leu  Leu Thr His 
    1910                 1915                 1920             


Phe Ser  Asn Asp Leu Thr Leu  Tyr Ser His Asn Gln  Leu Tyr Gly 
    1925                 1930                 1935             


Val Trp  Arg Val Val Asp Thr  Gly Glu Glu Pro Gln  Thr Thr Arg 
    1940                 1945                 1950             


Val Leu  Arg Val Lys Leu Gln  Thr Ala Asp Lys Thr  Ile Leu Leu 
    1955                 1960                 1965             


Tyr Ser  Ala Ser Asp Ile Glu  Met Leu Thr Pro Glu  Gln Leu Thr 
    1970                 1975                 1980             


Thr His  Pro Phe Leu Gln Arg  Val Gly Pro Asp Val  Leu Asp Pro 
    1985                 1990                 1995             


Asn Leu  Thr Pro Glu Val Val  Lys Glu Arg Leu Leu  Ser Pro Arg 
    2000                 2005                 2010             


Phe Arg  Asn Arg Gln Phe Ala  Gly Leu Leu Leu Asp  Gln Ala Phe 
    2015                 2020                 2025             


Leu Ala  Gly Leu Gly Asn Tyr  Leu Arg Val Glu Ile  Leu Trp Gln 
    2030                 2035                 2040             


Val Gly  Leu Thr Gly Asn His  Lys Ala Lys Asp Leu  Asn Ala Ala 
    2045                 2050                 2055             


Gln Leu  Asp Ala Leu Ala His  Ala Leu Leu Glu Ile  Pro Arg Phe 
    2060                 2065                 2070             


Ser Tyr  Ala Thr Arg Gly Gln  Val Asp Glu Asn Lys  His His Gly 
    2075                 2080                 2085             


Ala Leu  Phe Arg Phe Lys Val  Phe His Arg Asp Gly  Glu Pro Cys 
    2090                 2095                 2100             


Glu Arg  Cys Gly Ser Ile Ile  Glu Lys Thr Thr Leu  Ser Ser Arg 
    2105                 2110                 2115             


Pro Phe  Tyr Trp Cys Pro Gly  Cys Gln His Pro Lys  Lys Lys Arg 
    2120                 2125                 2130             


Lys Val  
    2135 


<210>  11
<211>  2133
<212>  PRT
<213>  artificial sequence

<220>
<223>  eAFID-3

<400>  11

Met Glu Ile Leu Arg Tyr Leu Met Asp Pro Asp Thr Phe Thr Phe Asn 
1               5                   10                  15      


Phe Asn Asn Asp Pro Leu Val Leu Arg Arg Arg Gln Thr Tyr Leu Cys 
            20                  25                  30          


Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Trp Val Leu Met Asp Gln 
        35                  40                  45              


His Met Gly Phe Leu Cys Asn Glu Ala Lys Asn Leu Leu Cys Gly Phe 
    50                  55                  60                  


Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro Ser Leu 
65                  70                  75                  80  


Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp 
                85                  90                  95      


Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala Phe Leu 
            100                 105                 110         


Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr 
        115                 120                 125             


Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg Asp Ala 
    130                 135                 140                 


Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Glu Tyr Cys Trp 
145                 150                 155                 160 


Asp Thr Phe Val Tyr Arg Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly 
                165                 170                 175     


Leu Glu Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu 
            180                 185                 190         


Gln Asn Gln Gly Asn Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
        195                 200                 205             


Ala Thr Pro Glu Ser Leu Lys Asp Lys Lys Tyr Ser Ile Gly Leu Asp 
    210                 215                 220                 


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
225                 230                 235                 240 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
                245                 250                 255     


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
            260                 265                 270         


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
        275                 280                 285             


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
    290                 295                 300                 


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
305                 310                 315                 320 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
                325                 330                 335     


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
            340                 345                 350         


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
        355                 360                 365             


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
    370                 375                 380                 


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
385                 390                 395                 400 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
                405                 410                 415     


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
            420                 425                 430         


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
        435                 440                 445             


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
    450                 455                 460                 


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
465                 470                 475                 480 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
                485                 490                 495     


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
            500                 505                 510         


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
        515                 520                 525             


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
    530                 535                 540                 


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
545                 550                 555                 560 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
                565                 570                 575     


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
            580                 585                 590         


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
        595                 600                 605             


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
    610                 615                 620                 


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
625                 630                 635                 640 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
                645                 650                 655     


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
            660                 665                 670         


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
        675                 680                 685             


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
    690                 695                 700                 


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
705                 710                 715                 720 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
                725                 730                 735     


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
            740                 745                 750         


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
        755                 760                 765             


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
    770                 775                 780                 


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
785                 790                 795                 800 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
                805                 810                 815     


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
            820                 825                 830         


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
        835                 840                 845             


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
    850                 855                 860                 


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
865                 870                 875                 880 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
                885                 890                 895     


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
            900                 905                 910         


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
        915                 920                 925             


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
    930                 935                 940                 


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
945                 950                 955                 960 


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
                965                 970                 975     


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
            980                 985                 990         


Glu Arg Met Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
        995                 1000                 1005             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1010                 1015                 1020             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1025                 1030                 1035             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1040                 1045                 1050             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1055                 1060                 1065             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1070                 1075                 1080             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1085                 1090                 1095             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1100                 1105                 1110             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1115                 1120                 1125             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1130                 1135                 1140             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1145                 1150                 1155             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1160                 1165                 1170             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1175                 1180                 1185             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1190                 1195                 1200             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1205                 1210                 1215             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1220                 1225                 1230             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1235                 1240                 1245             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1250                 1255                 1260             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1265                 1270                 1275             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1280                 1285                 1290             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1295                 1300                 1305             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1310                 1315                 1320             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1325                 1330                 1335             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1340                 1345                 1350             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1355                 1360                 1365             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1370                 1375                 1380             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1385                 1390                 1395             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1400                 1405                 1410             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1415                 1420                 1425             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1430                 1435                 1440             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1445                 1450                 1455             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1460                 1465                 1470             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1475                 1480                 1485             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1490                 1495                 1500             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1505                 1510                 1515             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1520                 1525                 1530             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1535                 1540                 1545             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1550                 1555                 1560             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1565                 1570                 1575             


Leu Gly  Gly Asp Lys Arg Pro  Ala Ala Thr Lys Lys  Ala Gly Gln 
    1580                 1585                 1590             


Ala Lys  Lys Lys Lys Thr Arg  Asp Ser Gly Gly Ser  Ala Asn Glu 
    1595                 1600                 1605             


Leu Thr  Trp His Asp Val Leu  Ala Glu Glu Lys Gln  Gln Pro Tyr 
    1610                 1615                 1620             


Phe Leu  Asn Thr Leu Gln Thr  Val Ala Ser Glu Arg  Gln Ser Gly 
    1625                 1630                 1635             


Val Thr  Ile Tyr Pro Pro Gln  Lys Asp Val Phe Asn  Ala Phe Arg 
    1640                 1645                 1650             


Phe Thr  Glu Leu Gly Asp Val  Lys Val Val Ile Leu  Gly Gln Asp 
    1655                 1660                 1665             


Pro Tyr  His Gly Pro Gly Gln  Ala His Gly Leu Ala  Phe Ser Val 
    1670                 1675                 1680             


Arg Pro  Gly Ile Ala Ile Pro  Pro Ser Leu Leu Asn  Met Tyr Lys 
    1685                 1690                 1695             


Glu Leu  Glu Asn Thr Ile Pro  Gly Phe Thr Arg Pro  Asn His Gly 
    1700                 1705                 1710             


Tyr Leu  Glu Ser Trp Ala Arg  Gln Gly Val Leu Leu  Leu Asn Thr 
    1715                 1720                 1725             


Val Leu  Thr Val Arg Ala Gly  Gln Ala His Ser His  Ala Ser Leu 
    1730                 1735                 1740             


Gly Trp  Glu Thr Phe Thr Asp  Lys Val Ile Ser Leu  Ile Asn Gln 
    1745                 1750                 1755             


His Arg  Glu Gly Val Val Phe  Leu Leu Trp Gly Ser  His Ala Gln 
    1760                 1765                 1770             


Lys Lys  Gly Ala Ile Ile Asp  Lys Gln Arg His His  Val Leu Lys 
    1775                 1780                 1785             


Ala Pro  His Pro Ser Pro Leu  Ser Ala His Arg Gly  Phe Phe Gly 
    1790                 1795                 1800             


Cys Asn  His Phe Val Leu Ala  Asn Gln Trp Leu Glu  Gln Arg Gly 
    1805                 1810                 1815             


Glu Thr  Pro Ile Asp Trp Met  Pro Val Leu Pro Ala  Glu Ser Glu 
    1820                 1825                 1830             


Pro Lys  Lys Lys Arg Lys Val  Ser Ala Gly Ser Gly  Ala Thr Asn 
    1835                 1840                 1845             


Phe Ser  Leu Leu Lys Gln Ala  Gly Asp Val Glu Glu  Asn Pro Gly 
    1850                 1855                 1860             


Pro Pro  Glu Gly Pro Glu Ile  Arg Arg Ala Ala Asp  Asn Leu Glu 
    1865                 1870                 1875             


Ala Ala  Ile Lys Gly Lys Pro  Leu Thr Asp Val Trp  Phe Ala Phe 
    1880                 1885                 1890             


Pro Gln  Leu Lys Pro Tyr Gln  Ser Gln Leu Ile Gly  Gln His Val 
    1895                 1900                 1905             


Thr His  Val Glu Thr Arg Gly  Lys Ala Leu Leu Thr  His Phe Ser 
    1910                 1915                 1920             


Asn Asp  Leu Thr Leu Tyr Ser  His Asn Gln Leu Tyr  Gly Val Trp 
    1925                 1930                 1935             


Arg Val  Val Asp Thr Gly Glu  Glu Pro Gln Thr Thr  Arg Val Leu 
    1940                 1945                 1950             


Arg Val  Lys Leu Gln Thr Ala  Asp Lys Thr Ile Leu  Leu Tyr Ser 
    1955                 1960                 1965             


Ala Ser  Asp Ile Glu Met Leu  Thr Pro Glu Gln Leu  Thr Thr His 
    1970                 1975                 1980             


Pro Phe  Leu Gln Arg Val Gly  Pro Asp Val Leu Asp  Pro Asn Leu 
    1985                 1990                 1995             


Thr Pro  Glu Val Val Lys Glu  Arg Leu Leu Ser Pro  Arg Phe Arg 
    2000                 2005                 2010             


Asn Arg  Gln Phe Ala Gly Leu  Leu Leu Asp Gln Ala  Phe Leu Ala 
    2015                 2020                 2025             


Gly Leu  Gly Asn Tyr Leu Arg  Val Glu Ile Leu Trp  Gln Val Gly 
    2030                 2035                 2040             


Leu Thr  Gly Asn His Lys Ala  Lys Asp Leu Asn Ala  Ala Gln Leu 
    2045                 2050                 2055             


Asp Ala  Leu Ala His Ala Leu  Leu Glu Ile Pro Arg  Phe Ser Tyr 
    2060                 2065                 2070             


Ala Thr  Arg Gly Gln Val Asp  Glu Asn Lys His His  Gly Ala Leu 
    2075                 2080                 2085             


Phe Arg  Phe Lys Val Phe His  Arg Asp Gly Glu Pro  Cys Glu Arg 
    2090                 2095                 2100             


Cys Gly  Ser Ile Ile Glu Lys  Thr Thr Leu Ser Ser  Arg Pro Phe 
    2105                 2110                 2115             


Tyr Trp  Cys Pro Gly Cys Gln  His Pro Lys Lys Lys  Arg Lys Val 
    2120                 2125                 2130             


