                         SEQUENCE LISTING

<110>  Monsanto Technology LLC
       Garvey, Graeme S
       Moshiri, Farhad
 
<120>  Compositions and Methods for Generating Diversity at Targeted 
       Nucleic Acid Sequences

<130>  P34716WO00/0024021.00915

<150>  US 62/842184
<151>  2019-05-02

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  4029
<212>  DNA
<213>  Escherichia coli

<400>  1
atggtttact cctataccga gaaaaaacgt attcgtaagg attttggtaa acgtccacaa       60

gttctggatg taccttatct cctttctatc cagcttgact cgtttcagaa atttatcgag      120

caagatcctg aagggcagta tggtctggaa gctgctttcc gttccgtatt cccgattcag      180

agctacagcg gtaattccga gctgcaatac gtcagctacc gccttggcga accggtgttt      240

gacgtccagg aatgtcaaat ccgtggcgtg acctattccg caccgctgcg cgttaaactg      300

cgtctggtga tctatgagcg cgaagcgccg gaaggcaccg taaaagacat taaagaacaa      360

gaagtctaca tgggcgaaat tccgctcatg acagacaacg gtacctttgt tatcaacggt      420

actgagcgtg ttatcgtttc ccagctgcac cgtagtccgg gcgtcttctt tgactccgac      480

aaaggtaaaa cccactcttc gggtaaagtg ctgtataacg cgcgtatcat cccttaccgt      540

ggttcctggc tggacttcga attcgatccg aaggacaacc tgttcgtacg tatcgaccgt      600

cgccgtaaac tgcctgcgac catcattctg cgcgccctga actacaccac agagcagatc      660

ctcgacctgt tctttgaaaa agttatcttt gaaatccgtg ataacaagct gcagatggaa      720

ctggtgccgg aacgcctgcg tggtgaaacc gcatcttttg acatcgaagc taacggtaaa      780

gtgtacgtag aaaaaggccg ccgtatcact gcgcgccaca ttcgccagct ggaaaaagac      840

gacgtcaaac tgatcgaagt cccggttgag tacatcgcag gtaaagtggt tgctaaagac      900

tatattgatg agtctaccgg cgagctgatc tgcgcagcga acatggagct gagcctggat      960

ctgctggcta agctgagcca gtctggtcac aagcgtatcg aaacgctgtt caccaacgat     1020

ctggatcacg gcccatatat ctctgaaacc ttacgtgtcg acccaactaa cgaccgtctg     1080

agcgcactgg tagaaatcta ccgcatgatg cgccctggcg agccgccgac tcgtgaagca     1140

gctgaaagcc tgttcgagaa cctgttcttc tccgaagacc gttatgactt gtctgcggtt     1200

ggtcgtatga agttcaaccg ttctctgctg cgcgaagaaa tcgaaggttc cggtatcctg     1260

agcaaagacg acatcattga tgttatgaaa aagctcatcg atatccgtaa cggtaaaggc     1320

gaagtcgatg atatcgacca cctcggcaac cgtcgtatcc gttccgttgg cgaaatggcg     1380

gaaaaccagt tccgcgttgg cctggtacgt gtagagcgtg cggtgaaaga gcgtctgtct     1440

ctgggcgatc tggataccct gatgccacag gatatgatca acgccaagcc gatttccgca     1500

gcagtgaaag agttcttcgg ttccagccag ctgtctcagt ttatggacca gaacaacccg     1560

ctgtctgaga ttacgcacaa acgtcgtatc tccgcactcg gcccaggcgg tctgacccgt     1620

gaacgtgcag gcttcgaagt tcgagacgta cacccgactc actacggtcg cgtatgtcca     1680

atcgaaaccc ctgaaggtcc gaacatcggt ctgatcaact ctctgtccgt gtacgcacag     1740

actaacgaat acggcttcct tgagactccg tatcgtaaag tgaccgacgg tgttgtaact     1800

gacgaaattc actacctgtc tgctatcgaa gaaggcaact acgttatcgc ccaggcgaac     1860

tccaacttgg atgaagaagg ccacttcgta gaagacctgg taacttgccg tagcaaaggc     1920

gaatccagct tgttcagccg cgaccaggtt gactacatgg acgtatccac ccagcaggtg     1980

gtatccgtcg gtgcgtccct gatcccgttc ctggaacacg atgacgccaa ccgtgcattg     2040

atgggtgcga acatgcaacg tcaggccgtt ccgactctgc gcgctgataa gccgctggtt     2100

ggtactggta tggaacgtgc tgttgccgtt gactccggtg taactgcggt agctaaacgt     2160

ggtggtgtcg ttcagtacgt ggatgcttcc cgtatcgtta tcaaagttaa cgaagacgag     2220

atgtatccgg gtgaagcagg tatcgacatc tacaacctga ccaaatacac ccgttctaac     2280

cagaacacct gtatcaacca gatgccgtgt gtgtctctgg gtgaaccggt tgaacgtggc     2340

gacgtgctgg cagacggtcc gtccaccgac ctcggtgaac tggcgcttgg tcagaacatg     2400

cgcgtagcgt tcatgccgtg gaatggttac aacttcgaag actccatcct cgtatccgag     2460

cgtgttgttc aggaagaccg tttcaccacc atccacattc aggaactggc gtgtgtgtcc     2520

cgtgacacca agctgggtcc ggaagagatc accgctgaca tcccgaacgt gggtgaagct     2580

gcgctctcca aactggatga atccggtatc gtttacattg gtgcggaagt gaccggtggc     2640

gacattctgg ttggtaaggt aacgccgaaa ggtgaaactc agctgacccc agaagaaaaa     2700

ctgctgcgtg cgatcttcgg tgagaaagcc tctgacgtta aagactcttc tctgcgcgta     2760

ccaaacggtg tatccggtac ggttatcgac gttcaggtct ttactcgcga tggcgtagaa     2820

aaagacaaac gtgcgctgga aatcgaagaa atgcagctca aacaggcgaa gaaagacctg     2880

tctgaagaac tgcagatcct cgaagcgggt ctgttcagcc gtatccgtgc tgtgctggta     2940

gccggtggcg ttgaagctga gaagctcgac aaactgccgc gcgatcgctg gctggagctg     3000

ggcctgacag acgaagagaa acaaaatcag ctggaacagc tggctgagca gtatgacgaa     3060

ctgaaacacg agttcgagaa gaaactcgaa gcgaaacgcc gcaaaatcac ccagggcgac     3120

gatctggcac cgggcgtgct gaagattgtt aaggtatatc tggcggttaa acgccgtatc     3180

cagcctggtg acaagatggc aggtcgtcac ggtaacaagg gtgtaatttc taagatcaac     3240

ccgatcgaag atatgcctta cgatgaaaac ggtacgccgg tagacatcgt actgaacccg     3300

ctgggcgtac cgtctcgtat gaacatcggt cagatcctcg aaacccacct gggtatggct     3360

gcgaaaggta tcggcgacaa gatcaacgcc atgctgaaac agcagcaaga agtcgcgaaa     3420

ctgcgcgaat tcatccagcg tgcgtacgat ctgggcgctg acgttcgtca gaaagttgac     3480

ctgagtacct tcagcgatga agaagttatg cgtctggctg aaaacctgcg caaaggtatg     3540

ccaatcgcaa cgccggtgtt cgacggtgcg aaagaagcag aaattaaaga gctgctgaaa     3600

cttggcgacc tgccgacttc cggtcagatc cgcctgtacg atggtcgcac tggtgaacag     3660

ttcgagcgtc cggtaaccgt tggttacatg tacatgctga aactgaacca cctggtcgac     3720

gacaagatgc acgcgcgttc caccggttct tacagcctgg ttactcagca gccgctgggt     3780

ggtaaggcac agttcggtgg tcagcgtttc ggggagatgg aagtgtgggc gctggaagca     3840

tacggcgcag catacaccct gcaggaaatg ctcaccgtta agtctgatga cgtgaacggt     3900

cgtaccaaga tgtataaaaa catcgtggac ggcaaccatc agatggagcc gggcatgcca     3960

gaatccttca acgtattgtt gaaagagatt cgttcgctgg gtatcaacat cgaactggaa     4020

gacgagtaa                                                             4029


<210>  2
<211>  1342
<212>  PRT
<213>  Escherichia coli

<400>  2

Met Val Tyr Ser Tyr Thr Glu Lys Lys Arg Ile Arg Lys Asp Phe Gly 
1               5                   10                  15      


Lys Arg Pro Gln Val Leu Asp Val Pro Tyr Leu Leu Ser Ile Gln Leu 
            20                  25                  30          


Asp Ser Phe Gln Lys Phe Ile Glu Gln Asp Pro Glu Gly Gln Tyr Gly 
        35                  40                  45              


Leu Glu Ala Ala Phe Arg Ser Val Phe Pro Ile Gln Ser Tyr Ser Gly 
    50                  55                  60                  


Asn Ser Glu Leu Gln Tyr Val Ser Tyr Arg Leu Gly Glu Pro Val Phe 
65                  70                  75                  80  


Asp Val Gln Glu Cys Gln Ile Arg Gly Val Thr Tyr Ser Ala Pro Leu 
                85                  90                  95      


Arg Val Lys Leu Arg Leu Val Ile Tyr Glu Arg Glu Ala Pro Glu Gly 
            100                 105                 110         


Thr Val Lys Asp Ile Lys Glu Gln Glu Val Tyr Met Gly Glu Ile Pro 
        115                 120                 125             


Leu Met Thr Asp Asn Gly Thr Phe Val Ile Asn Gly Thr Glu Arg Val 
    130                 135                 140                 


Ile Val Ser Gln Leu His Arg Ser Pro Gly Val Phe Phe Asp Ser Asp 
145                 150                 155                 160 


Lys Gly Lys Thr His Ser Ser Gly Lys Val Leu Tyr Asn Ala Arg Ile 
                165                 170                 175     


Ile Pro Tyr Arg Gly Ser Trp Leu Asp Phe Glu Phe Asp Pro Lys Asp 
            180                 185                 190         


Asn Leu Phe Val Arg Ile Asp Arg Arg Arg Lys Leu Pro Ala Thr Ile 
        195                 200                 205             


Ile Leu Arg Ala Leu Asn Tyr Thr Thr Glu Gln Ile Leu Asp Leu Phe 
    210                 215                 220                 


Phe Glu Lys Val Ile Phe Glu Ile Arg Asp Asn Lys Leu Gln Met Glu 
225                 230                 235                 240 


Leu Val Pro Glu Arg Leu Arg Gly Glu Thr Ala Ser Phe Asp Ile Glu 
                245                 250                 255     


Ala Asn Gly Lys Val Tyr Val Glu Lys Gly Arg Arg Ile Thr Ala Arg 
            260                 265                 270         


His Ile Arg Gln Leu Glu Lys Asp Asp Val Lys Leu Ile Glu Val Pro 
        275                 280                 285             


Val Glu Tyr Ile Ala Gly Lys Val Val Ala Lys Asp Tyr Ile Asp Glu 
    290                 295                 300                 


Ser Thr Gly Glu Leu Ile Cys Ala Ala Asn Met Glu Leu Ser Leu Asp 
305                 310                 315                 320 


Leu Leu Ala Lys Leu Ser Gln Ser Gly His Lys Arg Ile Glu Thr Leu 
                325                 330                 335     


Phe Thr Asn Asp Leu Asp His Gly Pro Tyr Ile Ser Glu Thr Leu Arg 
            340                 345                 350         


Val Asp Pro Thr Asn Asp Arg Leu Ser Ala Leu Val Glu Ile Tyr Arg 
        355                 360                 365             


Met Met Arg Pro Gly Glu Pro Pro Thr Arg Glu Ala Ala Glu Ser Leu 
    370                 375                 380                 


Phe Glu Asn Leu Phe Phe Ser Glu Asp Arg Tyr Asp Leu Ser Ala Val 
385                 390                 395                 400 


Gly Arg Met Lys Phe Asn Arg Ser Leu Leu Arg Glu Glu Ile Glu Gly 
                405                 410                 415     


Ser Gly Ile Leu Ser Lys Asp Asp Ile Ile Asp Val Met Lys Lys Leu 
            420                 425                 430         


Ile Asp Ile Arg Asn Gly Lys Gly Glu Val Asp Asp Ile Asp His Leu 
        435                 440                 445             


Gly Asn Arg Arg Ile Arg Ser Val Gly Glu Met Ala Glu Asn Gln Phe 
    450                 455                 460                 


Arg Val Gly Leu Val Arg Val Glu Arg Ala Val Lys Glu Arg Leu Ser 
465                 470                 475                 480 


Leu Gly Asp Leu Asp Thr Leu Met Pro Gln Asp Met Ile Asn Ala Lys 
                485                 490                 495     


Pro Ile Ser Ala Ala Val Lys Glu Phe Phe Gly Ser Ser Gln Leu Ser 
            500                 505                 510         


Gln Phe Met Asp Gln Asn Asn Pro Leu Ser Glu Ile Thr His Lys Arg 
        515                 520                 525             


Arg Ile Ser Ala Leu Gly Pro Gly Gly Leu Thr Arg Glu Arg Ala Gly 
    530                 535                 540                 


Phe Glu Val Arg Asp Val His Pro Thr His Tyr Gly Arg Val Cys Pro 
545                 550                 555                 560 


Ile Glu Thr Pro Glu Gly Pro Asn Ile Gly Leu Ile Asn Ser Leu Ser 
                565                 570                 575     


Val Tyr Ala Gln Thr Asn Glu Tyr Gly Phe Leu Glu Thr Pro Tyr Arg 
            580                 585                 590         


Lys Val Thr Asp Gly Val Val Thr Asp Glu Ile His Tyr Leu Ser Ala 
        595                 600                 605             


Ile Glu Glu Gly Asn Tyr Val Ile Ala Gln Ala Asn Ser Asn Leu Asp 
    610                 615                 620                 


Glu Glu Gly His Phe Val Glu Asp Leu Val Thr Cys Arg Ser Lys Gly 
625                 630                 635                 640 


Glu Ser Ser Leu Phe Ser Arg Asp Gln Val Asp Tyr Met Asp Val Ser 
                645                 650                 655     


Thr Gln Gln Val Val Ser Val Gly Ala Ser Leu Ile Pro Phe Leu Glu 
            660                 665                 670         


His Asp Asp Ala Asn Arg Ala Leu Met Gly Ala Asn Met Gln Arg Gln 
        675                 680                 685             


Ala Val Pro Thr Leu Arg Ala Asp Lys Pro Leu Val Gly Thr Gly Met 
    690                 695                 700                 


Glu Arg Ala Val Ala Val Asp Ser Gly Val Thr Ala Val Ala Lys Arg 
705                 710                 715                 720 


Gly Gly Val Val Gln Tyr Val Asp Ala Ser Arg Ile Val Ile Lys Val 
                725                 730                 735     


Asn Glu Asp Glu Met Tyr Pro Gly Glu Ala Gly Ile Asp Ile Tyr Asn 
            740                 745                 750         


Leu Thr Lys Tyr Thr Arg Ser Asn Gln Asn Thr Cys Ile Asn Gln Met 
        755                 760                 765             


Pro Cys Val Ser Leu Gly Glu Pro Val Glu Arg Gly Asp Val Leu Ala 
    770                 775                 780                 


Asp Gly Pro Ser Thr Asp Leu Gly Glu Leu Ala Leu Gly Gln Asn Met 
785                 790                 795                 800 


Arg Val Ala Phe Met Pro Trp Asn Gly Tyr Asn Phe Glu Asp Ser Ile 
                805                 810                 815     


Leu Val Ser Glu Arg Val Val Gln Glu Asp Arg Phe Thr Thr Ile His 
            820                 825                 830         


Ile Gln Glu Leu Ala Cys Val Ser Arg Asp Thr Lys Leu Gly Pro Glu 
        835                 840                 845             


Glu Ile Thr Ala Asp Ile Pro Asn Val Gly Glu Ala Ala Leu Ser Lys 
    850                 855                 860                 


Leu Asp Glu Ser Gly Ile Val Tyr Ile Gly Ala Glu Val Thr Gly Gly 
865                 870                 875                 880 


Asp Ile Leu Val Gly Lys Val Thr Pro Lys Gly Glu Thr Gln Leu Thr 
                885                 890                 895     


Pro Glu Glu Lys Leu Leu Arg Ala Ile Phe Gly Glu Lys Ala Ser Asp 
            900                 905                 910         


Val Lys Asp Ser Ser Leu Arg Val Pro Asn Gly Val Ser Gly Thr Val 
        915                 920                 925             


Ile Asp Val Gln Val Phe Thr Arg Asp Gly Val Glu Lys Asp Lys Arg 
    930                 935                 940                 


Ala Leu Glu Ile Glu Glu Met Gln Leu Lys Gln Ala Lys Lys Asp Leu 
945                 950                 955                 960 


Ser Glu Glu Leu Gln Ile Leu Glu Ala Gly Leu Phe Ser Arg Ile Arg 
                965                 970                 975     


Ala Val Leu Val Ala Gly Gly Val Glu Ala Glu Lys Leu Asp Lys Leu 
            980                 985                 990         


Pro Arg Asp Arg Trp Leu Glu Leu  Gly Leu Thr Asp Glu  Glu Lys Gln 
        995                 1000                 1005             


Asn Gln  Leu Glu Gln Leu Ala  Glu Gln Tyr Asp Glu  Leu Lys His 
    1010                 1015                 1020             


Glu Phe  Glu Lys Lys Leu Glu  Ala Lys Arg Arg Lys  Ile Thr Gln 
    1025                 1030                 1035             


Gly Asp  Asp Leu Ala Pro Gly  Val Leu Lys Ile Val  Lys Val Tyr 
    1040                 1045                 1050             


Leu Ala  Val Lys Arg Arg Ile  Gln Pro Gly Asp Lys  Met Ala Gly 
    1055                 1060                 1065             


Arg His  Gly Asn Lys Gly Val  Ile Ser Lys Ile Asn  Pro Ile Glu 
    1070                 1075                 1080             


Asp Met  Pro Tyr Asp Glu Asn  Gly Thr Pro Val Asp  Ile Val Leu 
    1085                 1090                 1095             


Asn Pro  Leu Gly Val Pro Ser  Arg Met Asn Ile Gly  Gln Ile Leu 
    1100                 1105                 1110             


Glu Thr  His Leu Gly Met Ala  Ala Lys Gly Ile Gly  Asp Lys Ile 
    1115                 1120                 1125             


Asn Ala  Met Leu Lys Gln Gln  Gln Glu Val Ala Lys  Leu Arg Glu 
    1130                 1135                 1140             


Phe Ile  Gln Arg Ala Tyr Asp  Leu Gly Ala Asp Val  Arg Gln Lys 
    1145                 1150                 1155             


Val Asp  Leu Ser Thr Phe Ser  Asp Glu Glu Val Met  Arg Leu Ala 
    1160                 1165                 1170             


Glu Asn  Leu Arg Lys Gly Met  Pro Ile Ala Thr Pro  Val Phe Asp 
    1175                 1180                 1185             


Gly Ala  Lys Glu Ala Glu Ile  Lys Glu Leu Leu Lys  Leu Gly Asp 
    1190                 1195                 1200             


Leu Pro  Thr Ser Gly Gln Ile  Arg Leu Tyr Asp Gly  Arg Thr Gly 
    1205                 1210                 1215             


Glu Gln  Phe Glu Arg Pro Val  Thr Val Gly Tyr Met  Tyr Met Leu 
    1220                 1225                 1230             


Lys Leu  Asn His Leu Val Asp  Asp Lys Met His Ala  Arg Ser Thr 
    1235                 1240                 1245             


Gly Ser  Tyr Ser Leu Val Thr  Gln Gln Pro Leu Gly  Gly Lys Ala 
    1250                 1255                 1260             


Gln Phe  Gly Gly Gln Arg Phe  Gly Glu Met Glu Val  Trp Ala Leu 
    1265                 1270                 1275             


Glu Ala  Tyr Gly Ala Ala Tyr  Thr Leu Gln Glu Met  Leu Thr Val 
    1280                 1285                 1290             


Lys Ser  Asp Asp Val Asn Gly  Arg Thr Lys Met Tyr  Lys Asn Ile 
    1295                 1300                 1305             


Val Asp  Gly Asn His Gln Met  Glu Pro Gly Met Pro  Glu Ser Phe 
    1310                 1315                 1320             


Asn Val  Leu Leu Lys Glu Ile  Arg Ser Leu Gly Ile  Asn Ile Glu 
    1325                 1330                 1335             


Leu Glu  Asp Glu 
    1340         


<210>  3
<211>  268
<212>  DNA
<213>  Escherichia coli

<400>  3
gccgatttcc gcagcagtga aagagttctt cggttccagc cagctgtctc agtttatgga       60

ccagaacaac ccgctgtctg agattacgca caaacgtcgt atctccgcac tcggcccagg      120

cggtctgacc cgtgaacgtg caggcttcga agttcgagac gtacacccga ctcactacgg      180

tcgcgtatgt ccaatcgaaa cccctgaagg tccgaacatc ggtctgatca actctctgtc      240

cgtgtacgca cagactaacg aatacggc                                         268


<210>  4
<211>  25
<212>  DNA
<213>  Escherichia coli

<400>  4
tggaccagaa caacccgctg tctga                                             25


<210>  5
<211>  24
<212>  DNA
<213>  Escherichia coli

<400>  5
tgcgtaatct cagacagcgg gttg                                              24


<210>  6
<211>  27
<212>  DNA
<213>  Escherichia coli

<400>  6
ttgttctggt ccataaactg agacagc                                           27


<210>  7
<211>  24
<212>  DNA
<213>  Escherichia coli

<400>  7
gcacaaacgt cgtatctccg cact                                              24


<210>  8
<211>  23
<212>  DNA
<213>  Escherichia coli

<400>  8
cgtcgtatct ccgcactcgg ccc                                               23


<210>  9
<211>  23
<212>  DNA
<213>  Zea mays

<400>  9
gtataatatg atggcatgcc ctc                                               23


<210>  10
<211>  20
<212>  DNA
<213>  Zea mays

<400>  10
gccggccagc atttgaaaca                                                   20


<210>  11
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  11
ttgacagcta gctcagtcct aggtataat                                         29


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  12
aatttctact cttgtagat                                                    19


<210>  13
<211>  83
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  13
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

ggcaccgagt cggtgctttt ttt                                               83


<210>  14
<211>  3681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  14
agcaaactgg aaaaattcac caacctgtac tccctgagca aaaccctgcg cttcaaagcg       60

atcccggttg gtaaaaccca ggaaaacatc gataacaagc gcctcctggt cgaagacgag      120

aaacgcgcag aggactacaa aggcgtcaaa aagctgctcg atcgctacta cctgagcttc      180

atcaacgatg tgttgcacag catcaaactg aagaacctga acaactacat cagcctgttc      240

cgcaagaaaa cccgtaccga aaaagagaac aaagaactgg aaaacctgga aattaacctg      300

cgtaaagaaa tcgctaaagc gttcaaaggt aacgagggct acaaatctct gttcaaaaag      360

gacatcatcg aaaccatcct gccggaattt ctggatgaca aagatgaaat cgcgctggtg      420

aactcgttca acggcttcac gaccgcgttc acgggtttct tcgacaaccg cgagaacatg      480

tttagcgagg aagcgaaaag caccagcatc gccttccgta tcatcaacga aaacctgacc      540

cgctacatca gcaacatgga cattttcgag aaggttgacg ctatctttga caaacacgag      600

gttcaggaga tcaaggagaa aatcctgaac agcgactacg atgtggaaga cttcttcgaa      660

ggcgagttct tcaacttcgt tctgacccaa gagggcatcg acgtttacaa cgccatcatt      720

ggcggcttcg taaccgaaag cggtgaaaag atcaaagggc tgaacgagta tatcaacctg      780

tataaccaga aaaccaaaca gaaactgccg aaattcaagc cgctgtacaa gcaggttctg      840

tccgaccgcg agagcctgag cttctatggc gagggctaca cgtccgacga ggaagtgctc      900

gaagtcttcc gcaacaccct gaacaagaac agcgagatct tctcgtccat caaaaagctg      960

gagaaactgt tcaagaactt cgacgagtac tcttctgcgg gcatcttcgt gaaaaacggc     1020

ccggccatca gcacgatttc caaggatatc tttggcgagt ggaacgtgat ccgcgacaaa     1080

tggaacgctg aatacgacga catccatctg aagaagaagg cggtcgttac cgaaaaatac     1140

gaagatgacc gccgcaagtc ttttaaaaag atcggctcgt tcagcctgga gcagctgcag     1200

gaatacgcgg acgctgactt gagcgtggtc gagaaactga aagagatcat catccagaag     1260

gtcgacgaaa tctacaaagt gtacggcagt agcgaaaaac tgttcgacgc tgatttcgtc     1320

ctggaaaaga gcctgaaaaa gaacgacgcg gtggtggcga tcatgaagga cctgctggac     1380

agcgttaagt cgttcgaaaa ctacattaaa gcgtttttcg gggaaggcaa agaaaccaac     1440

cgcgacgaat ctttttacgg tgactttgtc ctcgcctacg acatcctgct caaagtcgac     1500

cacatctatg acgctatccg caactacgtg acccagaagc cgtacagcaa agacaaattc     1560

aagctgtact tccagaaccc ccagttcatg ggcggctggg ataaggacaa ggaaaccgac     1620

taccgcgcca ccatcctgcg ctacggtagc aaatattacc tggcgatcat ggacaaaaaa     1680

tacgccaaat ctttgcagaa aatcgacaag gacgacgtga acggtaacta cgaaaaaatt     1740

aactataaac tgctgccggg tccgaacaaa atgctgccga aagtgttctt cagcaaaaaa     1800

tggatggcat actacaaccc gtctgaagat attcagaaaa tctacaaaaa cggcaccttc     1860

aaaaaaggtg atatgttcaa cctgaacgat ctgcacaaac tgattgattt cttcaaggac     1920

tcgatctctc gttatccgaa atggtctaac gcgtacgact tcaacttcag cgaaaccgaa     1980

aaatacaaag atatcgcggg tttctatcgt gaagttgaag aacagggcta caaagtgtct     2040

ttcgaatccg cgtccaaaaa ggaagtggat aaactggtcg aagaaggtaa actgtacatg     2100

ttccagatct ataacaaaga cttcagcgat aaatcccatg gcaccccgaa cctgcacacc     2160

atgtacttca aactgctgtt cgatgaaaac aaccacggcc agatccgtct gtccggcggt     2220

gcagaactgt ttatgcgccg tgcgtccctg aaaaaagaag agctggtagt acatccggca     2280

aactctccga tcgctaacaa aaacccggac aacccgaaga aaaccaccac cctgagctat     2340

gatgtatata aagataaacg tttctccgaa gatcagtacg aactgcacat cccgatcgca     2400

attaacaaag cgccgaaaaa catcttcaaa atcaacaccg aagtgcgtgt tctgctgaaa     2460

cacgatgata acccgtacgt tattggcatc gaccgtggcg aacgtaacct gctgtacatc     2520

gttgtggttg acggtaaagg taacattgtg gaacagtata gcctgaacga aatcattaac     2580

aacttcaacg gtatccgtat caaaaccgat tatcacagcc tgctggataa aaaagaaaaa     2640

gaacgttttg aagcgcgtca gaactggacc agcatcgaaa acatcaaaga actgaaagcg     2700

ggctacatct cgcaggttgt tcacaaaatc gtggaactgg ttgaaaaata cgatgcagtt     2760

atcgcgctgg aagatctgaa cagcggtttc aaaaactcac gtgtaaaagt tgaaaaacag     2820

gtttaccaga aattcgaaaa aatgctgatt gataaactga actatatggt ggataaaaaa     2880

tctaacccga gcgcgactgg tggcgcactg aaaggctatc agatcaccaa caagttcgag     2940

agcttcaaaa gcatgagcac ccagaacggt ttcatcttct atatcccggc ctggctgacc     3000

tctaaaattg acccgagcac tggcttcgtg aacctgctga aaaccaaata cactagcatc     3060

gctgacagca aaaaattcat ctcctccttt gaccgtatca tgtacgtgcc ggaagaagac     3120

ctgttcgaat ttgcactgga ttacaaaaac ttctcccgca ctgacgccga ctatattaaa     3180

aaatggaaac tgtactctta tggtaaccgt atccgtatct tccgtaaccc gaagaaaaac     3240

aacgttttcg attgggaaga agtgccgctg accagcgcgt ataaagaact gttcaacaaa     3300

tacggcatta actaccagca gggcgacatt cgtgcgctgc tgctggaaca gtccgataaa     3360

gcgttctaca gctccttcat ggcactgatg tccctgatgc tgcagatgcg taacagcatt     3420

actggccgta ccgatgtgga tttcctgatc agcccggtta aaaactctga cggcatcttt     3480

tacgacagcc gtaactacga agcgcaggaa aacgcgattc tgccgaaaaa cgcggacgct     3540

aacggcgcat acaacatcgc acgtaaagtg ctgtgggcga tcggtcagtt caaaaaagcg     3600

gaagatgaaa aactggataa agtgaaaatc gcgatcagca acaaagaatg gctggaatac     3660

gcgcagacca gcgttaaaca c                                               3681


<210>  15
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  15
atgggtagca aaaagaggcg tatcaagcag gac                                    33


<210>  16
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  16
ggatctaaga agcgtaggat caagcaagat tgag                                   34


<210>  17
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  17
atgggcagca gccatcatca ccaccatcac cat                                    33


<210>  18
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  18
ttgacaatta atcatcggct cgtataatgt gtggaattgt gagcggataa caatttctag       60

aaataatttt gtttaacttt aagaaggaga tatacc                                 96


<210>  19
<211>  3684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  19
agcaaactgg aaaaattcac caactgttac tccctgagca aaaccctgcg cttcaaagcg       60

atcccggttg gtaaaaccca ggaaaacatc gataacaagc gcctcctggt cgaagacgag      120

aaacgcgcag aggactacaa aggcgtcaaa aagctgctcg atcgctacta cctgagcttc      180

atcaacgatg tgttgcacag catcaaactg aagaacctga acaactacat cagcctgttc      240

cgcaagaaaa cccgtaccga aaaagagaac aaagaactgg aaaacctgga aattaacctg      300

cgtaaagaaa tcgctaaagc gttcaaaggt aacgagggct acaaatctct gttcaaaaag      360

gacatcatcg aaaccatcct gccggaattt ctggatgaca aagatgaaat cgcgctggtg      420

aactcgttca acggcttcac gaccgcgttc acgggtttct tcgacaaccg cgagaacatg      480

tttagcgagg aagcgaaaag caccagcatc gccttccgtt gcatcaacga aaacctgacc      540

cgctacatca gcaacatgga cattttcgag aaggttgacg ctatctttga caaacacgag      600

gttcaggaga tcaaggagaa aatcctgaac agcgactacg atgtggaaga cttcttcgaa      660

ggcgagttct tcaacttcgt tctgacccaa gagggcatcg acgtttacaa cgccatcatt      720

ggcggcttcg taaccgaaag cggtgaaaag atcaaagggc tgaacgagta tatcaacctg      780

tataaccaga aaaccaaaca gaaactgccg aaattcaagc cgctgtacaa gcaggttctg      840

tccgaccgcg agagcctgag cttctatggc gagggctaca cgtccgacga ggaagtgctc      900

gaagtcttcc gcaacaccct gaacaagaac agcgagatct tctcgtccat caaaaagctg      960

gagaaactgt tcaagaactt cgacgagtac tcttctgcgg gcatcttcgt gaaaaacggc     1020

ccggccatca gcacgatttc caaggatatc tttggcgagt ggaacgtgat ccgcgacaaa     1080

tggaacgctg aatacgacga catccatctg aagaagaagg cggtcgttac cgaaaaatac     1140

gaagatgacc gccgcaagtc ttttaaaaag atcggctcgt tcagcctgga gcagctgcag     1200

gaatacgcgg acgctgactt gagcgtggtc gagaaactga aagagatcat catccagaag     1260

gtcgacgaaa tctacaaagt gtacggcagt agcgaaaaac tgttcgacgc tgatttcgtc     1320

ctggaaaaga gcctgaaaaa gaacgacgcg gtggtggcga tcatgaagga cctgctggac     1380

agcgttaagt cgttcgaaaa ctacattaaa gcgtttttcg gggaaggcaa agaaaccaac     1440

cgcgacgaat ctttttacgg tgactttgtc ctcgcctacg acatcctgct caaagtcgac     1500

cacatctatg acgctatccg caactacgtg acccagaagc cgtacagcaa agacaaattc     1560

aagctgtact tccagaaccc ccagttcatg ggcggctggg ataaggacaa ggaaaccgac     1620

taccgcgcca ccatcctgcg ctacggtagc aaatattacc tggcgatcat ggacaaaaaa     1680

tacgccaaat gtttgcagaa aatcgacaag gacgacgtga acggtaacta cgaaaaaatt     1740

aactataaac tgctgccggg tccgaacaaa atgctgccga aagtgttctt cagcaaaaaa     1800

tggatggcat actacaaccc gtctgaagat attcagaaaa tctacaaaaa cggcaccttc     1860

aaaaaaggtg atatgttcaa cctgaacgat tgccacaaac tgattgattt cttcaaggac     1920

tcgatctctc gttatccgaa atggtctaac gcgtacgact tcaacttcag cgaaaccgaa     1980

aaatacaaag atatcgcggg tttctatcgt gaagttgaag aacagggcta caaagtgtct     2040

ttcgaatccg cgtccaaaaa ggaagtggat aaactggtcg aagaaggtaa actgtacatg     2100

ttccagatct ataacaaaga cttcagcgat aaatcccatg gcaccccgaa cctgcacacc     2160

atgtacttca aactgctgtt cgatgaaaac aaccacggcc agatccgtct gtccggcggt     2220

gcagaactgt ttatgcgccg tgcgtccctg aaaaaagaag agctggtagt acatccggca     2280

aactctccga tcgctaacaa aaacccggac aacccgaaga aaaccaccac cctgagctat     2340

gatgtatata aagataaacg tttctccgaa gatcagtacg aactgcacat cccgatcgca     2400

attaacaaat gcccgaaaaa catcttcaaa atcaacaccg aagtgcgtgt tctgctgaaa     2460

cacgatgata acccgtacgt tattggcatc gcccgtggcg aacgtaacct gctgtacatc     2520

gttgtggttg acggtaaagg taacattgtg gaacagtata gcctgaacga aatcattaac     2580

aacttcaacg gtatccgtat caaaaccgat tatcacagcc tgctggataa aaaagaaaaa     2640

gaacgttttg aagcgcgtca gaactggacc agcatcgaaa acatcaaaga actgaaagcg     2700

ggctacatct cgcaggttgt tcacaaaatc tgtgaactgg ttgaaaaata cgatgcagtt     2760

atcgcgctgg cagatctgaa cagcggtttc aaaaactcac gtgtaaaagt tgaaaaacag     2820

gtttaccaga aattcgaaaa aatgctgatt gataaactga actatatggt ggataaaaaa     2880

tctaacccgt gcgcgactgg tggcgcactg aaaggctatc agatcaccaa caagttcgag     2940

agcttcaaaa gcatgagcac ccagaacggt ttcatcttct atatcccggc ctggctgacc     3000

tctaaaattg acccgagcac tggcttcgtg aacctgctga aaaccaaata cactagcatc     3060

gctgacagca aaaaattcat ctcctccttt gaccgtatca tgtacgtgcc ggaagaagac     3120

ctgttcgaat ttgcactgga ttacaaaaac ttctcccgca ctgacgccga ctatattaaa     3180

aaatggaaac tgtactctta tggtaaccgt atccgtatct tccgtaaccc gaagaaaaac     3240

aacgttttcg attgggaaga agtgtgcctg accagcgcgt ataaagaact gttcaacaaa     3300

tacggcatta actaccagca gggcgacatt cgtgcgctgc tgtgtgaaca gtccgataaa     3360

gcgttctaca gctccttcat ggcactgatg tccctgatgc tgcagatgcg taacagcatt     3420

actggccgta ccgatgtgga tttcctgatc agcccggtta aaaactctga cggcatcttt     3480

tacgacagcc gtaactacga agcgcaggaa aacgcgattc tgccgaaaaa cgcggacgct     3540

aacggcgcat acaacatcgc acgtaaagtg ctgtgggcga tcggtcagtt caaaaaagcg     3600

gaagatgaaa aactggataa agtgaaaatc gcgatcagca acaaagaatg gctggaatac     3660

gcgcagacca gcgttaagca tgca                                            3684


<210>  20
<211>  4101
<212>  DNA
<213>  Streptococcus pyogenes

<400>  20
gataagaaat actcaatagg cttagatatc ggcacaaata gcgtcggatg ggcggtgatc       60

actgatgaat ataaggttcc gtctaaaaag ttcaaggttc tgggaaatac agaccgccac      120

agtatcaaaa aaaatcttat aggggctctt ttatttgaca gtggagagac agcggaagcg      180

actcgtctca aacggacagc tcgtagaagg tatacacgtc ggaagaatcg tatttgttat      240

ctacaggaga ttttttcaaa tgagatggcg aaagtagatg atagtttctt tcatcgactt      300

gaagagtctt ttttggtgga agaagacaag aagcatgaac gtcatcctat ttttggaaat      360

atagtagatg aagttgctta tcatgagaaa tatccaacta tctatcatct gcgaaaaaaa      420

ttggtagatt ctactgataa agcggatttg cgcttaatct atttggcctt agcgcatatg      480

attaagtttc gtggtcattt tttgattgag ggagatttaa atcctgataa tagtgatgtg      540

gacaaactat ttatccagtt ggtacaaacc tacaatcaat tatttgaaga aaaccctatt      600

aacgcaagtg gagtagatgc taaagcgatt ctttctgcac gattgagtaa atcaagacga      660

ttagaaaatc tcattgctca gctccccggt gagaagaaaa atggcttatt tgggaatctc      720

attgctttgt cattgggttt gacccctaat tttaaatcaa attttgattt ggcagaagat      780

gctaaattac agctttcaaa agatacttac gatgatgatt tagataattt attggcgcaa      840

attggagatc aatatgctga tttgtttttg gcagctaaga atttatcaga tgctatttta      900

ctttcagata tcctaagagt aaatactgaa ataactaagg ctcccctatc agcttcaatg      960

attaaacgct acgatgaaca tcatcaagac ttgactcttt taaaagcttt agttcgacaa     1020

caacttccag aaaagtataa agaaatcttt tttgatcaat caaaaaacgg atatgcaggt     1080

tatattgatg ggggagctag ccaagaagaa ttttataaat ttatcaaacc aattttagaa     1140

aaaatggatg gtactgagga attattggtg aaactaaatc gtgaagattt gctgcgcaag     1200

caacggacct ttgacaacgg ctctattccc catcaaattc acttgggtga gctgcatgct     1260

attttgagaa gacaagaaga cttttatcca tttttaaaag acaatcgtga gaagattgaa     1320

aaaatcttga cttttcgaat tccttattat gttggtccat tggcgcgtgg caatagtcgt     1380

tttgcatgga tgactcggaa gtctgaagaa acaattaccc catggaattt tgaagaagtt     1440

gtcgataaag gtgcttcagc tcaatcattt attgaacgca tgacaaactt tgataaaaat     1500

cttccaaatg aaaaagtact accaaaacat agtttgcttt atgagtattt tacggtttat     1560

aacgaattga caaaggtcaa atatgttact gaaggaatgc gaaaaccagc atttctttca     1620

ggtgaacaga agaaagccat tgttgattta ctcttcaaaa caaatcgaaa agtaaccgtt     1680

aagcaattaa aagaagatta tttcaaaaaa atagaatgtt ttgatagtgt tgaaatttca     1740

ggagttgaag atagatttaa tgcttcatta ggtacctacc atgatttgct aaaaattatt     1800

aaagataaag attttttgga taatgaagaa aatgaagata tcttagagga tattgtttta     1860

acattgacct tatttgaaga tagggagatg attgaggaaa gacttaaaac atatgctcac     1920

ctctttgatg ataaggtgat gaaacagctt aaacgtcgcc gttatactgg ttggggacgt     1980

ttgtctcgaa aattgattaa tggtattagg gataagcaat ctggcaaaac aatattagat     2040

tttttgaaat cagatggttt tgccaatcgc aattttatgc agctgatcca tgatgatagt     2100

ttgacattta aagaagacat tcaaaaagca caagtgtctg gacaaggcga tagtttacat     2160

gaacatattg caaatttagc tggtagccct gctattaaaa aaggtatttt acagactgta     2220

aaagttgttg atgaattggt caaagtaatg gggcggcata agccagaaaa tatcgttatt     2280

gaaatggcac gtgaaaatca gacaactcaa aagggccaga aaaattcgcg agagcgtatg     2340

aaacgaatcg aagaaggtat caaagaatta ggaagtcaga ttcttaaaga gcatcctgtt     2400

gaaaatactc aattgcaaaa tgaaaagctc tatctctatt atctccaaaa tggaagagac     2460

atgtatgtgg accaagaatt agatattaat cgtttaagtg attatgatgt cgatcacatt     2520

gttccacaaa gtttccttaa agacgattca atagacaata aggtcttaac gcgttctgat     2580

aaaaatcgtg gtaaatcgga taacgttcca agtgaagaag tagtcaaaaa gatgaaaaac     2640

tattggagac aacttctaaa cgccaagtta atcactcaac gtaagtttga taatttaacg     2700

aaagctgaac gtggaggttt gagtgaactt gataaagctg gttttatcaa acgccaattg     2760

gttgaaactc gccaaatcac taagcatgtg gcacaaattt tggatagtcg catgaatact     2820

aaatacgatg aaaatgataa acttattcga gaggttaaag tgattacctt aaaatctaaa     2880

ttagtttctg acttccgaaa agatttccaa ttctataaag tacgtgagat taacaattac     2940

catcatgccc atgatgcgta tctaaatgcc gtcgttggaa ctgctttgat taagaaatat     3000

ccaaaacttg aatcggagtt tgtctatggt gattataaag tttatgatgt tcgtaaaatg     3060

attgctaagt ctgagcaaga aataggcaaa gcaaccgcaa aatatttctt ttactctaat     3120

atcatgaact tcttcaaaac agaaattaca cttgcaaatg gagagattcg caaacgccct     3180

ctaatcgaaa ctaatgggga aactggagaa attgtctggg ataaagggcg agattttgcc     3240

acagtgcgca aagtattgtc catgccccaa gtcaatattg tcaagaaaac agaagtacag     3300

acaggcggat tctccaagga gtcaatttta ccaaaaagaa attcggacaa gcttattgct     3360

cgtaaaaaag actgggatcc aaaaaaatat ggtggttttg atagtccaac ggtagcttat     3420

tcagtcctag tggttgctaa ggtggaaaaa gggaaatcga agaagttaaa atccgttaaa     3480

gagttactag ggatcacaat tatggaaaga agttcctttg aaaaaaatcc gattgacttt     3540

ttagaagcta aaggatataa ggaagttaaa aaagacttaa tcattaaact acctaaatat     3600

agtctttttg agttagaaaa cggtcgtaaa cggatgctgg ctagtgccgg agaattacaa     3660

aaaggaaatg agctggctct gccaagcaaa tatgtgaatt ttttatattt agctagtcat     3720

tatgaaaagt tgaagggtag tccagaagat aacgaacaaa aacaattgtt tgtggagcag     3780

cataagcatt atttagatga gattattgag caaatcagtg aattttctaa gcgtgttatt     3840

ttagcagatg ccaatttaga taaagttctt agtgcatata acaaacatag agacaaacca     3900

atacgtgaac aagcagaaaa tattattcat ttatttacgt tgacgaatct tggagctccc     3960

gctgctttta aatattttga tacaacaatt gatcgtaaac gatatacgtc tacaaaagaa     4020

gttttagatg ccactcttat ccatcaatcc atcactggtc tttatgaaac acgcattgat     4080

ttgagtcagc taggaggtga c                                               4101


<210>  21
<211>  4101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  21
gataagaaat actcaatagg cttagctatc ggcacaaata gcgtcggatg ggcggtgatc       60

actgatgaat ataaggttcc gtctaaaaag ttcaaggttc tgggaaatac agaccgccac      120

agtatcaaaa aaaatcttat aggggctctt ttatttgaca gtggagagac agcggaagcg      180

actcgtctca aacggacagc tcgtagaagg tatacacgtc ggaagaatcg tatttgttat      240

ctacaggaga ttttttcaaa tgagatggcg aaagtagatg atagtttctt tcatcgactt      300

gaagagtctt ttttggtgga agaagacaag aagcatgaac gtcatcctat ttttggaaat      360

atagtagatg aagttgctta tcatgagaaa tatccaacta tctatcatct gcgaaaaaaa      420

ttggtagatt ctactgataa agcggatttg cgcttaatct atttggcctt agcgcatatg      480

attaagtttc gtggtcattt tttgattgag ggagatttaa atcctgataa tagtgatgtg      540

gacaaactat ttatccagtt ggtacaaacc tacaatcaat tatttgaaga aaaccctatt      600

aacgcaagtg gagtagatgc taaagcgatt ctttctgcac gattgagtaa atcaagacga      660

ttagaaaatc tcattgctca gctccccggt gagaagaaaa atggcttatt tgggaatctc      720

attgctttgt cattgggttt gacccctaat tttaaatcaa attttgattt ggcagaagat      780

gctaaattac agctttcaaa agatacttac gatgatgatt tagataattt attggcgcaa      840

attggagatc aatatgctga tttgtttttg gcagctaaga atttatcaga tgctatttta      900

ctttcagata tcctaagagt aaatactgaa ataactaagg ctcccctatc agcttcaatg      960

attaaacgct acgatgaaca tcatcaagac ttgactcttt taaaagcttt agttcgacaa     1020

caacttccag aaaagtataa agaaatcttt tttgatcaat caaaaaacgg atatgcaggt     1080

tatattgatg ggggagctag ccaagaagaa ttttataaat ttatcaaacc aattttagaa     1140

aaaatggatg gtactgagga attattggtg aaactaaatc gtgaagattt gctgcgcaag     1200

caacggacct ttgacaacgg ctctattccc catcaaattc acttgggtga gctgcatgct     1260

attttgagaa gacaagaaga cttttatcca tttttaaaag acaatcgtga gaagattgaa     1320

aaaatcttga cttttcgaat tccttattat gttggtccat tggcgcgtgg caatagtcgt     1380

tttgcatgga tgactcggaa gtctgaagaa acaattaccc catggaattt tgaagaagtt     1440

gtcgataaag gtgcttcagc tcaatcattt attgaacgca tgacaaactt tgataaaaat     1500

cttccaaatg aaaaagtact accaaaacat agtttgcttt atgagtattt tacggtttat     1560

aacgaattga caaaggtcaa atatgttact gaaggaatgc gaaaaccagc atttctttca     1620

ggtgaacaga agaaagccat tgttgattta ctcttcaaaa caaatcgaaa agtaaccgtt     1680

aagcaattaa aagaagatta tttcaaaaaa atagaatgtt ttgatagtgt tgaaatttca     1740

ggagttgaag atagatttaa tgcttcatta ggtacctacc atgatttgct aaaaattatt     1800

aaagataaag attttttgga taatgaagaa aatgaagata tcttagagga tattgtttta     1860

acattgacct tatttgaaga tagggagatg attgaggaaa gacttaaaac atatgctcac     1920

ctctttgatg ataaggtgat gaaacagctt aaacgtcgcc gttatactgg ttggggacgt     1980

ttgtctcgaa aattgattaa tggtattagg gataagcaat ctggcaaaac aatattagat     2040

tttttgaaat cagatggttt tgccaatcgc aattttatgc agctgatcca tgatgatagt     2100

ttgacattta aagaagacat tcaaaaagca caagtgtctg gacaaggcga tagtttacat     2160

gaacatattg caaatttagc tggtagccct gctattaaaa aaggtatttt acagactgta     2220

aaagttgttg atgaattggt caaagtaatg gggcggcata agccagaaaa tatcgttatt     2280

gaaatggcac gtgaaaatca gacaactcaa aagggccaga aaaattcgcg agagcgtatg     2340

aaacgaatcg aagaaggtat caaagaatta ggaagtcaga ttcttaaaga gcatcctgtt     2400

gaaaatactc aattgcaaaa tgaaaagctc tatctctatt atctccaaaa tggaagagac     2460

atgtatgtgg accaagaatt agatattaat cgtttaagtg attatgatgt cgatgccatt     2520

gttccacaaa gtttccttaa agacgattca atagacaata aggtcttaac gcgttctgat     2580

aaaaatcgtg gtaaatcgga taacgttcca agtgaagaag tagtcaaaaa gatgaaaaac     2640

tattggagac aacttctaaa cgccaagtta atcactcaac gtaagtttga taatttaacg     2700

aaagctgaac gtggaggttt gagtgaactt gataaagctg gttttatcaa acgccaattg     2760

gttgaaactc gccaaatcac taagcatgtg gcacaaattt tggatagtcg catgaatact     2820

aaatacgatg aaaatgataa acttattcga gaggttaaag tgattacctt aaaatctaaa     2880

ttagtttctg acttccgaaa agatttccaa ttctataaag tacgtgagat taacaattac     2940

catcatgccc atgatgcgta tctaaatgcc gtcgttggaa ctgctttgat taagaaatat     3000

ccaaaacttg aatcggagtt tgtctatggt gattataaag tttatgatgt tcgtaaaatg     3060

attgctaagt ctgagcaaga aataggcaaa gcaaccgcaa aatatttctt ttactctaat     3120

atcatgaact tcttcaaaac agaaattaca cttgcaaatg gagagattcg caaacgccct     3180

ctaatcgaaa ctaatgggga aactggagaa attgtctggg ataaagggcg agattttgcc     3240

acagtgcgca aagtattgtc catgccccaa gtcaatattg tcaagaaaac agaagtacag     3300

acaggcggat tctccaagga gtcaatttta ccaaaaagaa attcggacaa gcttattgct     3360

cgtaaaaaag actgggatcc aaaaaaatat ggtggttttg atagtccaac ggtagcttat     3420

tcagtcctag tggttgctaa ggtggaaaaa gggaaatcga agaagttaaa atccgttaaa     3480

gagttactag ggatcacaat tatggaaaga agttcctttg aaaaaaatcc gattgacttt     3540

ttagaagcta aaggatataa ggaagttaaa aaagacttaa tcattaaact acctaaatat     3600

agtctttttg agttagaaaa cggtcgtaaa cggatgctgg ctagtgccgg agaattacaa     3660

aaaggaaatg agctggctct gccaagcaaa tatgtgaatt ttttatattt agctagtcat     3720

tatgaaaagt tgaagggtag tccagaagat aacgaacaaa aacaattgtt tgtggagcag     3780

cataagcatt atttagatga gattattgag caaatcagtg aattttctaa gcgtgttatt     3840

ttagcagatg ccaatttaga taaagttctt agtgcatata acaaacatag agacaaacca     3900

atacgtgaac aagcagaaaa tattattcat ttatttacgt tgacgaatct tggagctccc     3960

gctgctttta aatattttga tacaacaatt gatcgtaaac gatatacgtc tacaaaagaa     4020

gttttagatg ccactcttat ccatcaatcc atcactggtc tttatgaaac acgcattgat     4080

ttgagtcagc taggaggtga c                                               4101


<210>  22
<211>  1368
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  22

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  23
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  23

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  24
<211>  1229
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  24

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Ala 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Ala Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His Ala 
    1220                 1225                 


<210>  25
<211>  1228
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  25

Met Ser Lys Leu Glu Lys Phe Thr Asn Leu Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Ile Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Ser Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Leu His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Ala Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Val 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Ser Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Pro  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Leu Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  26
<211>  491
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  26
tggatgtaca gagtgatatt attgacacgc ccgggcgacg gatggtgatc cccctggcca       60

gtgcacgtct gctgtcagat aaagtctccc gtgaacttta cccggtggtg catatcgggg      120

atgaaagctg gcgcatgatg accaccgata tggccagtgt gccggtctcc gttatcgggg      180

aagaagtggc tgatctcagc caccgcgaaa atgacatcaa aaacgccatt aacctgatgt      240

tctggggaat ataagcttag tctatttagt ataatatgat ggcatgccct cttaggcagt      300

agccggccag catttgaaac atggtacttc gttttattta aaaaataata agttattatt      360

tattatttat ttgttttatc atttaaggta gtttaagctt ggctgttttg gcggatgaga      420

gaagattttc agcctgatac agattaaatc agaacgcaga agcggtctga taaaacagaa      480

tttgcctggc g                                                           491


<210>  27
<211>  3684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence.

<400>  27
agcaaactgg aaaaattcac caactgttac tccctgagca aaaccctgcg cttcaaagcg       60

atcccggttg gtaaaaccca ggaaaacatc gataacaagc gcctcctggt cgaagacgag      120

aaacgcgcag aggactacaa aggcgtcaaa aagctgctcg atcgctacta cctgagcttc      180

atcaacgatg tgttgcacag catcaaactg aagaacctga acaactacat cagcctgttc      240

cgcaagaaaa cccgtaccga aaaagagaac aaagaactgg aaaacctgga aattaacctg      300

cgtaaagaaa tcgctaaagc gttcaaaggt aacgagggct acaaatctct gttcaaaaag      360

gacatcatcg aaaccatcct gccggaattt ctggatgaca aagatgaaat cgcgctggtg      420

aactcgttca acggcttcac gaccgcgttc acgggtttct tcgacaaccg cgagaacatg      480

tttagcgagg aagcgaaaag caccagcatc gccttccgtt gcatcaacga aaacctgacc      540

cgctacatca gcaacatgga cattttcgag aaggttgacg ctatctttga caaacacgag      600

gttcaggaga tcaaggagaa aatcctgaac agcgactacg atgtggaaga cttcttcgaa      660

ggcgagttct tcaacttcgt tctgacccaa gagggcatcg acgtttacaa cgccatcatt      720

ggcggcttcg taaccgaaag cggtgaaaag atcaaagggc tgaacgagta tatcaacctg      780

tataaccaga aaaccaaaca gaaactgccg aaattcaagc cgctgtacaa gcaggttctg      840

tccgaccgcg agagcctgag cttctatggc gagggctaca cgtccgacga ggaagtgctc      900

gaagtcttcc gcaacaccct gaacaagaac agcgagatct tctcgtccat caaaaagctg      960

gagaaactgt tcaagaactt cgacgagtac tcttctgcgg gcatcttcgt gaaaaacggc     1020

ccggccatca gcacgatttc caaggatatc tttggcgagt ggaacgtgat ccgcgacaaa     1080

tggaacgctg aatacgacga catccatctg aagaagaagg cggtcgttac cgaaaaatac     1140

gaagatgacc gccgcaagtc ttttaaaaag atcggctcgt tcagcctgga gcagctgcag     1200

gaatacgcgg acgctgactt gagcgtggtc gagaaactga aagagatcat catccagaag     1260

gtcgacgaaa tctacaaagt gtacggcagt agcgaaaaac tgttcgacgc tgatttcgtc     1320

ctggaaaaga gcctgaaaaa gaacgacgcg gtggtggcga tcatgaagga cctgctggac     1380

agcgttaagt cgttcgaaaa ctacattaaa gcgtttttcg gggaaggcaa agaaaccaac     1440

cgcgacgaat ctttttacgg tgactttgtc ctcgcctacg acatcctgct caaagtcgac     1500

cacatctatg acgctatccg caactacgtg acccagaagc cgtacagcaa agacaaattc     1560

aagctgtact tccagaaccc ccagttcatg ggcggctggg ataaggacaa ggaaaccgac     1620

taccgcgcca ccatcctgcg ctacggtagc aaatattacc tggcgatcat ggacaaaaaa     1680

tacgccaaat gtttgcagaa aatcgacaag gacgacgtga acggtaacta cgaaaaaatt     1740

aactataaac tgctgccggg tccgaacaaa atgctgccga aagtgttctt cagcaaaaaa     1800

tggatggcat actacaaccc gtctgaagat attcagaaaa tctacaaaaa cggcaccttc     1860

aaaaaaggtg atatgttcaa cctgaacgat tgccacaaac tgattgattt cttcaaggac     1920

tcgatctctc gttatccgaa atggtctaac gcgtacgact tcaacttcag cgaaaccgaa     1980

aaatacaaag atatcgcggg tttctatcgt gaagttgaag aacagggcta caaagtgtct     2040

ttcgaatccg cgtccaaaaa ggaagtggat aaactggtcg aagaaggtaa actgtacatg     2100

ttccagatct ataacaaaga cttcagcgat aaatcccatg gcaccccgaa cctgcacacc     2160

atgtacttca aactgctgtt cgatgaaaac aaccacggcc agatccgtct gtccggcggt     2220

gcagaactgt ttatgcgccg tgcgtccctg aaaaaagaag agctggtagt acatccggca     2280

aactctccga tcgctaacaa aaacccggac aacccgaaga aaaccaccac cctgagctat     2340

gatgtatata aagataaacg tttctccgaa gatcagtacg aactgcacat cccgatcgca     2400

attaacaaat gcccgaaaaa catcttcaaa atcaacaccg aagtgcgtgt tctgctgaaa     2460

cacgatgata acccgtacgt tattggcatc gaccgtggcg aacgtaacct gctgtacatc     2520

gttgtggttg acggtaaagg taacattgtg gaacagtata gcctgaacga aatcattaac     2580

aacttcaacg gtatccgtat caaaaccgat tatcacagcc tgctggataa aaaagaaaaa     2640

gaacgttttg aagcgcgtca gaactggacc agcatcgaaa acatcaaaga actgaaagcg     2700

ggctacatct cgcaggttgt tcacaaaatc tgtgaactgg ttgaaaaata cgatgcagtt     2760

atcgcgctgg aagatctgaa cagcggtttc aaaaactcac gtgtaaaagt tgaaaaacag     2820

gtttaccaga aattcgaaaa aatgctgatt gataaactga actatatggt ggataaaaaa     2880

tctaacccgt gcgcgactgg tggcgcactg aaaggctatc agatcaccaa caagttcgag     2940

agcttcaaaa gcatgagcac ccagaacggt ttcatcttct atatcccggc ctggctgacc     3000

tctaaaattg acccgagcac tggcttcgtg aacctgctga aaaccaaata cactagcatc     3060

gctgacagca aaaaattcat ctcctccttt gaccgtatca tgtacgtgcc ggaagaagac     3120

ctgttcgaat ttgcactgga ttacaaaaac ttctcccgca ctgacgccga ctatattaaa     3180

aaatggaaac tgtactctta tggtaaccgt atccgtatct tccgtaaccc gaagaaaaac     3240

aacgttttcg attgggaaga agtgtgcctg accagcgcgt ataaagaact gttcaacaaa     3300

tacggcatta actaccagca gggcgacatt cgtgcgctgc tgtgtgaaca gtccgataaa     3360

gcgttctaca gctccttcat ggcactgatg tccctgatgc tgcagatgcg taacagcatt     3420

actggccgta ccgatgtgga tttcctgatc agcccggtta aaaactctga cggcatcttt     3480

tacgacagcc gtaactacga agcgcaggaa aacgcgattc tgccgaaaaa cgcggacgct     3540

aacggcgcat acaacatcgc acgtaaagtg ctgtgggcga tcggtcagtt caaaaaagcg     3600

gaagatgaaa aactggataa agtgaaaatc gcgatcagca acaaagaatg gctggaatac     3660

gcgcagacca gcgttaagca tgca                                            3684


<210>  28
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  28
guaauuucua cucuuguaga uguauaauau gauggcaugc ccuc                        44


<210>  29
<211>  630
<212>  DNA
<213>  Bacillus subtilis

<400>  29
atgggaaagg tttatgtatt tgatcatcct ttaattcagc acaagctgac atatatacgg       60

aatgaaaata caggtacgaa ggattttaga gagttagtag atgaagtggc tacactcatg      120

gcatttgaaa ttacccgcga tcttcctctg gaagaagtgg atatcaatac accggttcag      180

gctgcgaaat cgaaagtcat ctcagggaaa aaactcggag tggttcctat cctcagagca      240

ggattgggaa tggttgacgg cattttaaag ctgattcctg cggcaaaagt gggacatgtc      300

ggcctttacc gtgatccaga aaccttaaaa cccgtggaat actatgtcaa gcttccttct      360

gatgtggaag agcgtgaatt catcgtggtt gacccgatgc tcgctacagg cggttccgca      420

gttgaagcca ttcacagcct taaaaaacgc ggtgcgaaaa atatccgttt catgtgtctt      480

gtagcagcgc cggagggtgt ggaagaattg cagaagcatc attcggacgt tgatatttac      540

attgcggcgc tagatgaaaa attaaatgaa aaaggatata ttgttccagg tctcggagat      600

gcgggtgacc gcatgtttgg aacaaaataa                                       630


<210>  30
<211>  1980
<212>  DNA
<213>  Bacillus subtilis

<400>  30
atgtttgcaa aacgattcaa aacctcttta ctgccgttat tcgctggatt tttattgctg       60

tttcatttgg ttctggcagg accggcggct gcgagtgctg aaacggcgaa caaatcgaat      120

gagcttacag caccgtcgat caaaagcgga accattcttc atgcatggaa ttggtcgttc      180

aatacgttaa aacacaatat gaaggatatt catgatgcag gatatacagc cattcagaca      240

tctccgatta accaagtaaa ggaagggaat caaggagata aaagcatgtc gaactggtac      300

tggctgtatc agccgacatc gtatcaaatt ggcaaccgtt acttaggtac tgaacaagaa      360

tttaaagaaa tgtgtgcagc cgctgaagaa tatggcataa aggtcattgt tgacgcggtc      420

atcaatcata ccaccagtga ttatgccgcg atttccaatg aggttaagag tattccaaac      480

tggacacatg gaaacacaca aattaaaaac tggtctgatc gatgggatgt cacgcagaat      540

tcattgctcg ggctgtatga ctggaataca caaaatacac aagtacagtc ctatctgaaa      600

cggttcttag acagggcatt gaatgacggg gcagacggtt ttcgatttga tgccgccaaa      660

catatagagc ttccagatga tggcagttac ggcagtcaat tttggccgaa tatcacaaat      720

acatctgcag agttccaata cggagaaatc ctgcaggata gtgcctccag agatgctgca      780

tatgcgaatt atatggatgt gacagcgtct aactatgggc attccataag gtccgcttta      840

aagaatcgta atctgggcgt gtcgaatatc tcccactatg catctgatgt gtctgcggac      900

aagctagtga catgggtaga gtcgcatgat acgtatgcca atgatgatga agagtcgaca      960

tggatgagcg atgatgatat ccgtttaggc tgggcggtga tagcttctcg ttcaggcagt     1020

acgcctcttt tcttttccag acctgaggga ggcggaaatg gtgtgaggtt cccggggaaa     1080

agccaaatag gcgatcgcgg gagtgcttta tttgaagatc aggctatcac tgcggtcaat     1140

agatttcaca atgtgatggc tggacagcct gaggaactct cgaacccgaa tggaaacaac     1200

cagatattta tgaatcagcg cggctcacat ggcgttgtgc tggcaaatgc aggttcatcc     1260

tctgtctcta tcaatacggc aacaaaattg cctgatggca ggtatgacaa taaagctgga     1320

gcgggttcat ttcaagtgaa cgatggtaaa ctgacaggca cgatcaatgc caggtctgta     1380

gctgtgcttt atcctgatga tattgcaaaa gcgcctcatg ttttccttga gaattacaaa     1440

acaggtgtaa cacattcttt caatgatcaa ctgacgatta ccttgcgtgc agatgcgaat     1500

acaacaaaag ccgtttatca aatcaataat ggaccagaga cggcgtttaa ggatggagat     1560

caattcacaa tcggaaaagg agatccattt ggcaaaacat acaccatcat gttaaaagga     1620

acgaacagtg atggtgtaac gaggaccgag aaatacagtt ttgttaaaag agatccagcg     1680

tcggccaaaa ccatcggcta tcaaaatccg aatcattgga gccaggtaaa tgcttatatc     1740

tataaacatg atgggagccg agtaattgaa ttgaccggat cttggcctgg aaaaccaatg     1800

actaaaaatg cagacggaat ttacacgctg acgctgcctg cggacacgga tacaaccaac     1860

gcaaaagtga tttttaataa tggcagcgcc caagtgcccg gtcagaatca gcctggcttt     1920

gattacgtgc taaatggttt atataatgac tcgggcttaa gcggttctct tccccattga     1980


<210>  31
<211>  23
<212>  DNA
<213>  Bacillus subtilis

<400>  31
agataggact gtacttgtgt att                                               23


<210>  32
<211>  23
<212>  DNA
<213>  Bacillus subtilis

<400>  32
cccgggaacc tcacaccatt tcc                                               23


<210>  33
<211>  23
<212>  DNA
<213>  Bacillus subtilis

<400>  33
cctggctcca atgattcgga ttt                                               23


<210>  34
<211>  23
<212>  DNA
<213>  Bacillus subtilis

<400>  34
gcggcatcaa atcgaaaacc gtc                                               23


<210>  35
<211>  23
<212>  DNA
<213>  Bacillus subtilis

<400>  35
gaatactctt aacctcattg gaa                                               23


<210>  36
<211>  19
<212>  DNA
<213>  Bacillus subtilis

<400>  36
agcgccgcaa tgtaaatat                                                    19


<210>  37
<211>  19
<212>  DNA
<213>  Bacillus subtilis

<400>  37
cctgaaccgg tgtattgat                                                    19


<210>  38
<211>  19
<212>  DNA
<213>  Bacillus subtilis

<400>  38
gccgtcaacc attcccaat                                                    19


<210>  39
<211>  19
<212>  DNA
<213>  Bacillus subtilis

<400>  39
cgtatatatg tcagcttgt                                                    19


<210>  40
<211>  19
<212>  DNA
<213>  Bacillus subtilis

<400>  40
gccatgagtg tagccactt                                                    19


<210>  41
<211>  418
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence. Expression cassette for guide array targeting
       upp gene of B. subtilis

<400>  41
cctccttgac actgaattta gcatgtgata taattaactt aatattctac ccaagcttat       60

aaaagagcac tgttgggcgt gagtggaggc gccggaaaaa agcatcgaaa aaaaatttct      120

actaagtgta gatatctagc gccgcaatgt aaatataatt tctactaagt gtagatgcag      180

cctgaaccgg tgtattgata atttctacta agtgtagata aatgccgtca accattccca      240

ataatttcta ctaagtgtag atattccgta tatatgtcag cttgtaattt ctactaagtg      300

tagataaatg ccatgagtgt agccacttaa tttctactaa gtgtagattt ttcaattgca      360

tgaagaatct gcttacataa ccccttgggg cctctaaacg ggtcttgagg ggtttttt        418


<210>  42
<211>  418
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence. Expression cassette for guide array targeting
       amyE gene of B. subtilis

<400>  42
cctccttgac actgaattta gcatgtgata taattaactt aatattctac ccaagcttat       60

aaaagagcac tgttgggcgt gagtggaggc gccggaaaaa agcatcgaaa aaaaatttct      120

actaagtgta gatagatagg actgtacttg tgtattaatt tctactaagt gtagatcccg      180

ggaacctcac accatttcca atttctacta agtgtagatc ctggctccaa tgattcggat      240

ttaatttcta ctaagtgtag atgcggcatc aaatcgaaaa ccgtcaattt ctactaagtg      300

tagatgaata ctcttaacct cattggaaaa tttctactaa gtgtagattt ttcaattgca      360

tgaagaatct gcttacataa ccccttgggg cctctaaacg ggtcttgagg ggtttttt        418


<210>  43
<211>  3953
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence. Expression cassette for dLbCpf1 with N- and 
       C-terminal NLS sequences

<400>  43
ggcgcgccct aatttgacag tagaattagc atgtgatata ataaataatt tttactaccc       60

aagcttataa aagagcactg ttgggcgtga gtggaggcgc cggaaaaaag catcgaaaaa      120

aggaggaaaa aaacatatgg gtagcaaaaa gaggcgtatc aagcaggaca gcaaactgga      180

aaaattcacc aactgttact ccctgagcaa aaccctgcgc ttcaaagcga tcccggttgg      240

taaaacccag gaaaacatcg ataacaagcg cctcctggtc gaagacgaga aacgcgcaga      300

ggactacaaa ggcgtcaaaa agctgctcga tcgctactac ctgagcttca tcaacgatgt      360

gttgcacagc atcaaactga agaacctgaa caactacatc agcctgttcc gcaagaaaac      420

ccgtaccgaa aaagagaaca aagaactgga aaacctggaa attaacctgc gtaaagaaat      480

cgctaaagcg ttcaaaggta acgagggcta caaatctctg ttcaaaaagg acatcatcga      540

aaccatcctg ccggaatttc tggatgacaa agatgaaatc gcgctggtga actcgttcaa      600

cggcttcacg accgcgttca cgggtttctt cgacaaccgc gagaacatgt ttagcgagga      660

agcgaaaagc accagcatcg ccttccgttg catcaacgaa aacctgaccc gctacatcag      720

caacatggac attttcgaga aggttgacgc tatctttgac aaacacgagg ttcaggagat      780

caaggagaaa atcctgaaca gcgactacga tgtggaagac ttcttcgaag gcgagttctt      840

caacttcgtt ctgacccaag agggcatcga cgtttacaac gccatcattg gcggcttcgt      900

aaccgaaagc ggtgaaaaga tcaaagggct gaacgagtat atcaacctgt ataaccagaa      960

aaccaaacag aaactgccga aattcaagcc gctgtacaag caggttctgt ccgaccgcga     1020

gagcctgagc ttctatggcg agggctacac gtccgacgag gaagtgctcg aagtcttccg     1080

caacaccctg aacaagaaca gcgagatctt ctcgtccatc aaaaagctgg agaaactgtt     1140

caagaacttc gacgagtact cttctgcggg catcttcgtg aaaaacggcc cggccatcag     1200

cacgatttcc aaggatatct ttggcgagtg gaacgtgatc cgcgacaaat ggaacgctga     1260

atacgacgac atccatctga agaagaaggc ggtcgttacc gaaaaatacg aagatgaccg     1320

ccgcaagtct tttaaaaaga tcggctcgtt cagcctggag cagctgcagg aatacgcgga     1380

cgctgacttg agcgtggtcg agaaactgaa agagatcatc atccagaagg tcgacgaaat     1440

ctacaaagtg tacggcagta gcgaaaaact gttcgacgct gatttcgtcc tggaaaagag     1500

cctgaaaaag aacgacgcgg tggtggcgat catgaaggac ctgctggaca gcgttaagtc     1560

gttcgaaaac tacattaaag cgtttttcgg ggaaggcaaa gaaaccaacc gcgacgaatc     1620

tttttacggt gactttgtcc tcgcctacga catcctgctc aaagtcgacc acatctatga     1680

cgctatccgc aactacgtga cccagaagcc gtacagcaaa gacaaattca agctgtactt     1740

ccagaacccc cagttcatgg gcggctggga taaggacaag gaaaccgact accgcgccac     1800

catcctgcgc tacggtagca aatattacct ggcgatcatg gacaaaaaat acgccaaatg     1860

tttgcagaaa atcgacaagg acgacgtgaa cggtaactac gaaaaaatta actataaact     1920

gctgccgggt ccgaacaaaa tgctgccgaa agtgttcttc agcaaaaaat ggatggcata     1980

ctacaacccg tctgaagata ttcagaaaat ctacaaaaac ggcaccttca aaaaaggtga     2040

tatgttcaac ctgaacgatt gccacaaact gattgatttc ttcaaggact cgatctctcg     2100

ttatccgaaa tggtctaacg cgtacgactt caacttcagc gaaaccgaaa aatacaaaga     2160

tatcgcgggt ttctatcgtg aagttgaaga acagggctac aaagtgtctt tcgaatccgc     2220

gtccaaaaag gaagtggata aactggtcga agaaggtaaa ctgtacatgt tccagatcta     2280

taacaaagac ttcagcgata aatcccatgg caccccgaac ctgcacacca tgtacttcaa     2340

actgctgttc gatgaaaaca accacggcca gatccgtctg tccggcggtg cagaactgtt     2400

tatgcgccgt gcgtccctga aaaaagaaga gctggtagta catccggcaa actctccgat     2460

cgctaacaaa aacccggaca acccgaagaa aaccaccacc ctgagctatg atgtatataa     2520

agataaacgt ttctccgaag atcagtacga actgcacatc ccgatcgcaa ttaacaaatg     2580

cccgaaaaac atcttcaaaa tcaacaccga agtgcgtgtt ctgctgaaac acgatgataa     2640

cccgtacgtt attggcatcg cccgtggcga acgtaacctg ctgtacatcg ttgtggttga     2700

cggtaaaggt aacattgtgg aacagtatag cctgaacgaa atcattaaca acttcaacgg     2760

tatccgtatc aaaaccgatt atcacagcct gctggataaa aaagaaaaag aacgttttga     2820

agcgcgtcag aactggacca gcatcgaaaa catcaaagaa ctgaaagcgg gctacatctc     2880

gcaggttgtt cacaaaatct gtgaactggt tgaaaaatac gatgcagtta tcgcgctgga     2940

agatctgaac agcggtttca aaaactcacg tgtaaaagtt gaaaaacagg tttaccagaa     3000

attcgaaaaa atgctgattg ataaactgaa ctatatggtg gataaaaaat ctaacccgtg     3060

cgcgactggt ggcgcactga aaggctatca gatcaccaac aagttcgaga gcttcaaaag     3120

catgagcacc cagaacggtt tcatcttcta tatcccggcc tggctgacct ctaaaattga     3180

cccgagcact ggcttcgtga acctgctgaa aaccaaatac actagcatcg ctgacagcaa     3240

aaaattcatc tcctcctttg accgtatcat gtacgtgccg gaagaagacc tgttcgaatt     3300

tgcactggat tacaaaaact tctcccgcac tgacgccgac tatattaaaa aatggaaact     3360

gtactcttat ggtaaccgta tccgtatctt ccgtaacccg aagaaaaaca acgttttcga     3420

ttgggaagaa gtgtgcctga ccagcgcgta taaagaactg ttcaacaaat acggcattaa     3480

ctaccagcag ggcgacattc gtgcgctgct gtgtgaacag tccgataaag cgttctacag     3540

ctccttcatg gcactgatgt ccctgatgct gcagatgcgt aacagcatta ctggccgtac     3600

cgatgtggat ttcctgatca gcccggttaa aaactctgac ggcatctttt acgacagccg     3660

taactacgaa gcgcaggaaa acgcgattct gccgaaaaac gcggacgcta acggcgcata     3720

caacatcgca cgtaaagtgc tgtgggcgat cggtcagttc aaaaaagcgg aagatgaaaa     3780

actggataaa gtgaaaatcg cgatcagcaa caaagaatgg ctggaatacg cgcagaccag     3840

cgttaagcat gcaggatcta agaagcgtag gatcaagcaa gattgagcgg ccgctgagca     3900

ataactagca taaccccttg gggcctctaa acgggtcttg aggggttttt tgc            3953


