                               SEQUENCE LISTING

<110> INNATE BIOLOGICS, LLC
 
<120> IMMUNOMODULATORY COMPOSITIONS AND METHODS

<130> G6113-00029

<140>
<141>

<150> 62/841,312
<151> 2019-05-01

<160> 30    

<170> PatentIn version 3.5

<210> 1
<211> 219
<212> PRT
<213> Yersinia pestis

<400> 1
Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Gly Ser Gly Pro Leu Arg 
    130                 135                 140                 


Gly Ser Ile Thr Gln Cys Gln Gly Leu Met Gln Phe Cys Gly Gly Glu 
145                 150                 155                 160 


Leu Gln Ala Glu Ala Ser Ala Ile Leu Asn Thr Pro Val Cys Gly Ile 
                165                 170                 175     


Pro Phe Ser Gln Trp Gly Thr Val Gly Gly Ala Ala Ser Ala Tyr Val 
            180                 185                 190         


Ala Ser Gly Val Asp Leu Thr Gln Ala Ala Asn Glu Ile Lys Gly Leu 
        195                 200                 205             


Gly Gln Gln Met Gln Gln Leu Leu Ser Leu Met 
    210                 215                 


<210> 2
<211> 1152
<212> DNA
<213> Yersinia pestis

<400> 2
gaattcccca actttgacac cgataaccgg ttcaatagta tctggaatag acagcgaaag       60

ttgttgaaat aattgagtga tagcttgttc aaatgaatac atttgatctc ctaatagtta      120

gataaaatat caacttaacc aaagcactct cggcagacca tcaattttag cctataattt      180

ttagttttta ttttgtctaa tataacaaca aaaacagcag cggtttttta tataaccacc      240

ggctattttc ccactaagat aaccttgttt taatagccaa gggaataaat agtcatgaaa      300

atatcatcat ttatttctac atcactgccc ctgccggcat cagtgtcagg atctagcagc      360

gtaggagaaa tgtctgggcg ctcagtctca cagcaaaaaa gtgatcaata tgcaaacaat      420

ctggccgggc gcactgaaag ccctcagggt tccagcttag ccagccgtat cattgagagg      480

ttatcatcaa tggcccactc tgtgattgga tttatccaac gcatgttctc ggaggggagc      540

cataaaccgg tggtgacacc agcactcacg cctgcacaaa tgccaagccc tacgtctttc      600

agtgatagta tcaagcaact tgctgctgag acgctgccaa aatacatgca gcagttgagt      660

agcttggatg cagagacgct gcagaaaaat catgaccagt tcgccacggg cagcggccct      720

cttcgtggca gtatcactca atgccaaggg ctgatgcagt tttgtggtgg ggaattgcaa      780

gctgaggcca gtgccatttt aaacacgcct gtttgtggta ttcccttctc gcagtgggga      840

actgttggtg gggcggccag cgcgtacgtc gccagtggcg ttgatctaac gcaggcagca      900

aatgagatca aagggctggg gcaacagatg cagcaattac tgtcattgat gtgatatgga      960

taaaaacaag ggggtagtgt ttcccccttt ttctatcaat attgcgaata tcttcgtccc     1020

tgatctttca ggggcgaatc gttttttagc atgctcattg ttagaatttc tgacttatct     1080

ctcttctgta ttactactca tactctggaa aatcctgagc atttatatct atggattgat     1140

gcagcactcg ag                                                         1152


<210> 3
<211> 462
<212> PRT
<213> Shigella flexneri

<400> 3
Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


Gly Ser Met Ser Ile Glu Ile Lys Met Ile Ser Pro Ile Lys Asn Ile 
225                 230                 235                 240 


Lys Asn Val Phe Pro Ile Asn Thr Ala Asn Thr Glu Tyr Ile Val Arg 
                245                 250                 255     


Asn Ile Tyr Pro Arg Val Glu His Gly Tyr Phe Asn Glu Ser Pro Asn 
            260                 265                 270         


Ile Tyr Asp Lys Lys Tyr Ile Ser Gly Ile Thr Arg Ser Met Ala Gln 
        275                 280                 285             


Leu Lys Ile Glu Glu Phe Ile Asn Glu Lys Ser Arg Arg Leu Asn Tyr 
    290                 295                 300                 


Met Lys Thr Met Tyr Ser Pro Cys Pro Glu Asp Phe Gln Pro Ile Ser 
305                 310                 315                 320 


Arg Asp Glu Ala Ser Thr Pro Glu Gly Ser Trp Leu Thr Val Ile Ser 
                325                 330                 335     


Gly Lys Arg Pro Met Gly Gln Phe Ser Val Asp Ser Leu Tyr His Pro 
            340                 345                 350         


Asp Leu His Ala Leu Cys Glu Leu Pro Glu Ile Ser Cys Lys Ile Phe 
        355                 360                 365             


Pro Lys Glu Asn Ser Asp Phe Leu Tyr Ile Ile Val Val Phe Arg Asn 
    370                 375                 380                 


Asp Ser Pro Gln Gly Glu Leu Arg Ala Asn Arg Phe Ile Glu Leu Tyr 
385                 390                 395                 400 


Asp Ile Lys Arg Glu Ile Met Gln Val Leu Arg Asp Glu Ser Pro Glu 
                405                 410                 415     


Leu Lys Ser Ile Lys Ser Glu Ile Ile Ile Ala Arg Glu Met Gly Glu 
            420                 425                 430         


Leu Phe Ser Tyr Ala Ser Glu Glu Ile Asp Ser Tyr Ile Lys Gln Met 
        435                 440                 445             


Asn Asp Arg Leu Ser Gln Ile Lys Ala Arg Met Pro Val Thr 
    450                 455                 460         


<210> 4
<211> 1386
<212> DNA
<213> Shigella flexneri

<400> 4
atgagcccga ttctgggcta ttggaaaatt aaaggcctgg tgcagccgac ccgcctgctg       60

ctggaatatc tggaagaaaa atatgaagaa catctgtatg aacgcgatga aggcgataaa      120

tggcgcaaca aaaaatttga actgggcctg gaatttccga acctgccgta ttatattgat      180

ggcgatgtga aactgaccca gagcatggcg attattcgct atattgcgga taaacataac      240

atgctgggcg gctgcccgaa agaacgcgcg gaaattagca tgctggaagg cgcggtgctg      300

gatattcgct atggcgtgag ccgcattgcg tatagcaaag attttgaaac cctgaaagtg      360

gattttctga gcaaactgcc ggaaatgctg aaaatgtttg aagatcgcct gtgccataaa      420

acctatctga acggcgatca tgtgacccat ccggatttta tgctgtatga tgcgctggat      480

gtggtgctgt atatggatcc gatgtgcctg gatgcgtttc cgaaactggt gtgctttaaa      540

aaacgcattg aagcgattcc gcagattgat aaatatctga aaagcagcaa atatattgcg      600

tggccgctgc agggctggca ggcgaccttt ggcggcggcg atcatccgcc gaaaagcgat      660

ctggtgccgc gcggcagcat gagcattgaa attaaaatga ttagcccgat taaaaacatt      720

aaaaacgtgt ttccgattaa caccgcgaac accgaatata ttgtgcgcaa catttatccg      780

cgcgtggaac atggctattt taacgaaagc ccgaacattt atgataaaaa atatattagc      840

ggcattaccc gcagcatggc gcagctgaaa attgaagaat ttattaacga aaaaagccgc      900

cgcctgaact atatgaaaac catgtatagc ccgtgcccgg aagattttca gccgattagc      960

cgcgatgaag cgagcacccc ggaaggcagc tggctgaccg tgattagcgg caaacgcccg     1020

atgggccagt ttagcgtgga tagcctgtat catccggatc tgcatgcgct gtgcgaactg     1080

ccggaaatta gctgcaaaat ttttccgaaa gaaaacagcg attttctgta tattattgtg     1140

gtgtttcgca acgatagccc gcagggcgaa ctgcgcgcga accgctttat tgaactgtat     1200

gatattaaac gcgaaattat gcaggtgctg cgcgatgaaa gcccggaact gaaaagcatt     1260

aaaagcgaaa ttattattgc gcgcgaaatg ggcgaactgt ttagctatgc gagcgaagaa     1320

attgatagct atattaaaca gatgaacgat cgcctgagcc agattaaagc gcgcatgccg     1380

gtgacc                                                                1386


<210> 5
<211> 330
<212> PRT
<213> Citrobacter rodentium

<400> 5
Met Lys Ile Pro Ser Leu Gln Ser Asn Phe Asn Phe Ser Ala Pro Ala 
1               5                   10                  15      


Gly Tyr Ser Ala Pro Ile Ala Pro Asn Arg Ala Glu Asn Ala Tyr Ala 
            20                  25                  30          


Asp Tyr Val Leu Asp Ile Gly Lys Arg Ile Pro Leu Ser Ala Ala Asp 
        35                  40                  45              


Leu Ser Asn Val Tyr Glu Ser Val Ile Arg Ala Val His Asp Ser Arg 
    50                  55                  60                  


Ser Arg Leu Ile Asp Gln His Thr Val Asp Met Ile Gly Asn Thr Val 
65                  70                  75                  80  


Leu Asp Ala Leu Ser Arg Ser Gln Thr Phe Arg Asp Ala Val Ser Tyr 
                85                  90                  95      


Gly Ile His Asn Glu Lys Val His Ile Gly Cys Ile Lys Tyr Arg Asn 
            100                 105                 110         


Glu Tyr Glu Leu Asn Glu Glu Ser Ser Val Lys Ile Asp Asp Ile Gln 
        115                 120                 125             


Ser Leu Thr Cys Asn Glu Leu Tyr Glu Tyr Asp Val Gly Gln Glu Pro 
    130                 135                 140                 


Ile Phe Pro Ile Cys Glu Ala Gly Glu Asn Asp Asn Glu Glu Pro Tyr 
145                 150                 155                 160 


Val Ser Phe Ser Val Ala Pro Asp Thr Asp Ser Tyr Glu Met Pro Ser 
                165                 170                 175     


Trp Gln Glu Gly Leu Ile His Glu Ile Ile His His Val Thr Gly Ser 
            180                 185                 190         


Ser Asp Pro Ser Gly Asp Ser Asn Ile Glu Leu Gly Pro Thr Glu Ile 
        195                 200                 205             


Leu Ala Arg Arg Val Ala Gln Glu Leu Gly Trp Ser Val Pro Asp Phe 
    210                 215                 220                 


Lys Gly Tyr Ala Glu Pro Glu Arg Glu Ala His Leu Arg Leu Arg Asn 
225                 230                 235                 240 


Leu Asn Ala Leu Arg Gln Ala Ala Met Arg His Glu Glu Asn Glu Arg 
                245                 250                 255     


Ala Phe Phe Glu Arg Leu Gly Thr Ile Ser Asp Arg Tyr Glu Ala Ser 
            260                 265                 270         


Pro Asp Phe Thr Glu Tyr Ser Ala Val Ser Asn Ile Gly Tyr Gly Phe 
        275                 280                 285             


Ile Gln Gln His Asp Phe Pro Gly Leu Ala Ile Asn Asp Asn Leu Gln 
    290                 295                 300                 


Asp Ala Asn Gln Ile Gln Leu Tyr His Gly Ala Pro Tyr Ile Phe Thr 
305                 310                 315                 320 


Phe Gly Asp Val Asp Lys His Asn Gln Arg 
                325                 330 


<210> 6
<211> 1464
<212> DNA
<213> Citrobacter rodentium

<400> 6
gaattcatcc ggtcaaacgg cttctttttg caggaaagga atatgagtta aaggtcattg       60

atgaaaaaac gcctattatc ctgctctact tgagggattg tcttttatgc acagaagagt      120

agatgctcat ccatattatg atggtttagg taaagggata aagaaatatt ttgattttac      180

tcaattacat gattacaatc atttttatga ctttattgag tttaaacatc caaatattat      240

tatgaacaca agtcagtata caggcagttc atggtaaatg gtttttacat agtttattct      300

gttgtaataa atgattagca tggtattagg tatcaacatg aaaattccct cactccagcc      360

cagcttcaac tttttcgccc cagcaggata ctctgctgcc gttgctccca atcgttcgga      420

caatgcctat gctgattacg tattggatat aggcaagcga ataccacttt ccgcggaaga      480

tttaggcaac ctatatgaaa atgtcattcg cgccgttcgt gacagccgta gcaagctcat      540

agatcagcat acggtcgata tgattggtaa cactatactt gatgctttga gccgatcaca      600

aacctttcgt gatgccgtaa gctatggcat tcataataag gaggtacaca ttggttgcat      660

taaatacaga aacgaatacg agctcaacgg agaatccccc gtcaaagttg atgatattca      720

atcactaacc tgtaccgaat tatatgaata cgatgtcggg caagaaccaa ttttacccat      780

ttgcgaggca ggagaaaacg ataacgaaga gccttatgtc agttttagtg ttgcgccaga      840

tactgactct tatgagatgc catcgtggca ggaagggctg attcacgaga ttattcatca      900

tgtgactgga gctagcgatc cgtctggaga tagtaatata gagctaggac ccacggagat      960

tctcgcacgt cgtgtcgctc aagagctggg atggactgtc cccgacttca taggatatgc     1020

agagccagat cgtgaagctc atcttagggg acgtaacctg aatgcccttc gacaggcggc     1080

catgcgacat gaagataatg agaggacttt cttcgaaagg ctgggtatga tcagtgatcg     1140

atatgaggcg agtcctgatt tcacagagta ttccgctgtg tctaacatag aatatggatt     1200

tatccagcaa catgattttc ccgggttggc tatcgacgat aatttacagg atgcaaatca     1260

gatccaactc tatcatggag caccttatat ctttacattc ggggatgtgg acaaacacaa     1320

tcagcgctga cgcgtctttg cagcgacaca aggctactac tcttgcattt taacggagtt     1380

gatgatggaa aatcgtgcaa ccttgtatgt aaaggcgaaa aaccaaattt tacggtagta     1440

agtgagcctg gcgggaatgg tacc                                            1464


<210> 7
<211> 288
<212> PRT
<213> Yersinia pseudotuberculosis

<400> 7
Met Ile Gly Pro Ile Ser Gln Ile Asn Ile Ser Gly Gly Leu Ser Glu 
1               5                   10                  15      


Lys Glu Thr Ser Ser Leu Ile Ser Asn Glu Glu Leu Lys Asn Ile Ile 
            20                  25                  30          


Thr Gln Leu Glu Thr Asp Ile Ser Asp Gly Ser Trp Phe His Lys Asn 
        35                  40                  45              


Tyr Ser Arg Met Asp Val Glu Val Met Pro Ala Leu Val Ile Gln Ala 
    50                  55                  60                  


Asn Asn Lys Tyr Pro Glu Met Asn Leu Asn Leu Val Thr Ser Pro Leu 
65                  70                  75                  80  


Asp Leu Ser Ile Glu Ile Lys Asn Val Ile Glu Asn Gly Val Arg Ser 
                85                  90                  95      


Ser Arg Phe Ile Ile Asn Met Gly Glu Gly Gly Ile His Phe Ser Val 
            100                 105                 110         


Ile Asp Tyr Lys His Ile Asn Gly Lys Thr Ser Leu Ile Leu Phe Glu 
        115                 120                 125             


Pro Ala Asn Phe Asn Ser Met Gly Pro Ala Met Leu Ala Ile Arg Thr 
    130                 135                 140                 


Lys Thr Ala Ile Glu Arg Tyr Gln Leu Pro Asp Cys His Phe Ser Met 
145                 150                 155                 160 


Val Glu Met Asp Ile Gln Arg Ser Ser Ser Glu Cys Gly Ile Phe Ser 
                165                 170                 175     


Phe Ala Leu Ala Lys Lys Leu Tyr Ile Glu Arg Asp Ser Leu Leu Lys 
            180                 185                 190         


Ile His Glu Asp Asn Ile Lys Gly Ile Leu Ser Asp Gly Glu Asn Pro 
        195                 200                 205             


Leu Pro His Asp Lys Leu Asp Pro Tyr Leu Pro Val Thr Phe Tyr Lys 
    210                 215                 220                 


His Thr Gln Gly Lys Lys Arg Leu Asn Glu Tyr Leu Asn Thr Asn Pro 
225                 230                 235                 240 


Gln Gly Val Gly Thr Val Val Asn Lys Lys Asn Glu Thr Ile Val Asn 
                245                 250                 255     


Arg Phe Asp Asn Asn Lys Ser Ile Val Asp Gly Lys Glu Leu Ser Val 
            260                 265                 270         


Ser Val His Lys Lys Arg Ile Ala Glu Tyr Lys Thr Leu Leu Lys Val 
        275                 280                 285             


<210> 8
<211> 867
<212> DNA
<213> Yersinia pseudotuberculosis

<400> 8
atgatcggac caatatcaca aataaatatc tccggtggct tatcagaaaa agagaccagt       60

tctttaatca gtaatgaaga gcttaaaaat atcataacac agttggaaac tgatatatcg      120

gatggatcct ggttccataa aaattattca cgtatggatg tagaagtcat gcccgcattg      180

gtaatccagg cgaacaataa atatccggaa atgaatctta atcttgttac atctccattg      240

gacctttcaa tagaaataaa aaacgtcata gaaaatggag ttagatcttc ccgcttcata      300

attaacatgg gggaaggtgg aatacatttc agtgtaattg attacaaaca tataaatggg      360

aaaacatctc tgatattgtt tgaaccagca aactttaaca gtatggggcc agcgatgctg      420

gcaataagga caaaaacggc tattgaacgt tatcaattac ctgattgcca tttctccatg      480

gtggaaatgg atattcagcg aagctcatct gaatgtggta tttttagttt tgcactggca      540

aaaaaacttt acatcgagag agatagcctg ttgaaaatac atgaagataa tataaaaggt      600

atattaagtg atggtgaaaa tcctttaccc cacgataagt tggacccgta tctcccggta      660

actttttaca aacatactca aggtaaaaaa cgtcttaatg aatatttaaa tactaacccg      720

cagggagttg gtactgttgt taacaaaaaa aatgaaacca tcgttaatag atttgataac      780

aataaatcca ttgtagatgg aaaggaatta tcagtttcgg tacataaaaa gagaatagct      840

gaatataaaa cacttctcaa agtataa                                          867


<210> 9
<211> 336
<212> PRT
<213> Escherichia coli

<400> 9
Met Ile Pro Pro Leu Asn Arg Tyr Val Pro Ala Leu Ser Lys Asn Glu 
1               5                   10                  15      


Leu Val Lys Thr Val Thr Asn Arg Asp Ile Gln Phe Thr Ser Phe Asn 
            20                  25                  30          


Gly Lys Asp Tyr Pro Leu Cys Phe Leu Asp Glu Lys Thr Pro Leu Leu 
        35                  40                  45              


Phe Gln Trp Phe Glu Arg Asn Pro Ala Arg Phe Gly Lys Asn Asp Ile 
    50                  55                  60                  


Pro Ile Ile Asn Thr Glu Lys Asn Pro Tyr Leu Asn Asn Ile Ile Lys 
65                  70                  75                  80  


Ala Ala Thr Ile Glu Lys Glu Arg Leu Ile Gly Ile Phe Val Asp Gly 
                85                  90                  95      


Asp Phe Phe Pro Gly Gln Lys Asp Ala Phe Ser Lys Leu Glu Tyr Asp 
            100                 105                 110         


Tyr Glu Asn Ile Lys Val Ile Tyr Arg Asn Asp Ile Asp Phe Ser Met 
        115                 120                 125             


Tyr Asp Lys Lys Leu Ser Glu Ile Tyr Met Glu Asn Ile Ser Lys Gln 
    130                 135                 140                 


Glu Ser Met Pro Glu Glu Lys Arg Asp Cys His Leu Leu Gln Leu Leu 
145                 150                 155                 160 


Lys Lys Glu Leu Ser Asp Ile Gln Glu Gly Asn Asp Ser Leu Ile Lys 
                165                 170                 175     


Ser Tyr Leu Leu Asp Lys Gly His Gly Trp Phe Asp Phe Tyr Arg Asn 
            180                 185                 190         


Met Ala Met Leu Lys Ala Gly Gln Leu Phe Leu Glu Ala Asp Lys Val 
        195                 200                 205             


Gly Cys Tyr Asp Leu Ser Thr Asn Ser Gly Cys Ile Tyr Leu Asp Ala 
    210                 215                 220                 


Asp Met Ile Ile Thr Glu Lys Leu Gly Gly Ile Tyr Ile Pro Asp Gly 
225                 230                 235                 240 


Ile Ala Val His Val Glu Arg Ile Asp Gly Arg Ala Ser Met Glu Asn 
                245                 250                 255     


Gly Ile Ile Ala Val Asp Arg Asn Asn His Pro Ala Leu Leu Ala Gly 
            260                 265                 270         


Leu Glu Ile Met His Thr Lys Phe Asp Ala Asp Pro Tyr Ser Asp Gly 
        275                 280                 285             


Val Cys Asn Gly Ile Arg Lys His Phe Asn Tyr Ser Leu Asn Glu Asp 
    290                 295                 300                 


Tyr Asn Ser Phe Cys Asp Phe Ile Glu Phe Lys His Asp Asn Ile Ile 
305                 310                 315                 320 


Met Asn Thr Ser Gln Phe Thr Gln Ser Ser Trp Ala Arg His Val Gln 
                325                 330                 335     


<210> 10
<211> 540
<212> DNA
<213> Escherichia coli

<400> 10
atgttatctc cattaaatgt tcttcaattt aatttcagag gagagaccgc tttatcagat       60

agtgctcctc tccagactgt ttcctttgct ggaaaagatt attctatgga acccattgat      120

gaaaaaacac ccattctttt tcagtggttt gaagcaaggc cagagcgata cggaaaaggt      180

gaagtaccga tattgaatac caaagagcat ccgtatttga gcaatattat aaatgctgca      240

aaaatagaaa atgagcgcgt aataggagta ctggtagacg gagactttac ttatgagcaa      300

agaaaagaat ttctcagtct tgaagatgaa catcaaaata taaagataat atatcgggaa      360

aatgttgatt tcagtatgta tgataaaaaa ctgtctgata tttatcttga aaatattcat      420

gaacaagaat catatccagc gagtgagaga gataattatc tgttaggctt attaagagaa      480

gagttaaaaa atattccata cggaaaggac tctttgattg aatcatatgc agaaaaaaga      540


<210> 11
<211> 545
<212> PRT
<213> Shigella flexneri

<400> 11
Met Leu Pro Ile Asn Asn Asn Phe Ser Leu Pro Gln Asn Ser Phe Tyr 
1               5                   10                  15      


Asn Thr Ile Ser Gly Thr Tyr Ala Asp Tyr Phe Ser Ala Trp Asp Lys 
            20                  25                  30          


Trp Glu Lys Gln Ala Leu Pro Gly Glu Glu Arg Asp Glu Ala Val Ser 
        35                  40                  45              


Arg Leu Lys Glu Cys Leu Ile Asn Asn Ser Asp Glu Leu Arg Leu Asp 
    50                  55                  60                  


Arg Leu Asn Leu Ser Ser Leu Pro Asp Asn Leu Pro Ala Gln Ile Thr 
65                  70                  75                  80  


Leu Leu Asn Val Ser Tyr Asn Gln Leu Thr Asn Leu Pro Glu Leu Pro 
                85                  90                  95      


Val Thr Leu Lys Lys Leu Tyr Ser Ala Ser Asn Lys Leu Ser Glu Leu 
            100                 105                 110         


Pro Val Leu Pro Pro Ala Leu Glu Ser Leu Gln Val Gln His Asn Glu 
        115                 120                 125             


Leu Glu Asn Leu Pro Ala Leu Pro Asp Ser Leu Leu Thr Met Asn Ile 
    130                 135                 140                 


Ser Tyr Asn Glu Ile Val Ser Leu Pro Ser Leu Pro Gln Ala Leu Lys 
145                 150                 155                 160 


Asn Leu Arg Ala Thr Arg Asn Phe Leu Thr Glu Leu Pro Ala Phe Ser 
                165                 170                 175     


Glu Gly Asn Asn Pro Val Val Arg Glu Tyr Phe Phe Asp Arg Asn Gln 
            180                 185                 190         


Ile Ser His Ile Pro Glu Ser Ile Leu Asn Leu Arg Asn Glu Cys Ser 
        195                 200                 205             


Ile His Ile Ser Asp Asn Pro Leu Ser Ser His Ala Leu Gln Ala Leu 
    210                 215                 220                 


Gln Arg Leu Thr Ser Ser Pro Asp Tyr His Gly Pro Arg Ile Tyr Phe 
225                 230                 235                 240 


Ser Met Ser Asp Gly Gln Gln Asn Thr Leu His Arg Pro Leu Ala Asp 
                245                 250                 255     


Ala Val Thr Ala Trp Phe Pro Glu Asn Lys Gln Ser Asp Val Ser Gln 
            260                 265                 270         


Ile Trp His Ala Phe Glu His Glu Glu His Ala Asn Thr Phe Ser Ala 
        275                 280                 285             


Phe Leu Asp Arg Leu Ser Asp Thr Val Ser Ala Arg Asn Thr Ser Gly 
    290                 295                 300                 


Phe Arg Glu Gln Val Ala Ala Trp Leu Glu Lys Leu Ser Ala Ser Ala 
305                 310                 315                 320 


Glu Leu Arg Gln Gln Ser Phe Ala Val Ala Ala Asp Ala Thr Glu Ser 
                325                 330                 335     


Cys Glu Asp Arg Val Ala Leu Thr Trp Asn Asn Leu Arg Lys Thr Leu 
            340                 345                 350         


Leu Val His Gln Ala Ser Glu Gly Leu Phe Asp Asn Asp Thr Gly Ala 
        355                 360                 365             


Leu Leu Ser Leu Gly Arg Glu Met Phe Arg Leu Glu Ile Leu Glu Asp 
    370                 375                 380                 


Ile Ala Arg Asp Lys Val Arg Thr Leu His Phe Val Asp Glu Ile Glu 
385                 390                 395                 400 


Val Tyr Leu Ala Phe Gln Thr Met Leu Ala Glu Lys Leu Gln Leu Ser 
                405                 410                 415     


Thr Ala Val Lys Glu Met Arg Phe Tyr Gly Val Ser Gly Val Thr Ala 
            420                 425                 430         


Asn Asp Leu Arg Thr Ala Glu Ala Met Val Arg Ser Arg Glu Glu Asn 
        435                 440                 445             


Glu Phe Thr Asp Trp Phe Ser Leu Trp Gly Pro Trp His Ala Val Leu 
    450                 455                 460                 


Lys Arg Thr Glu Ala Asp Arg Trp Ala Gln Ala Glu Glu Gln Lys Tyr 
465                 470                 475                 480 


Glu Met Leu Glu Asn Glu Tyr Pro Gln Arg Val Ala Asp Arg Leu Lys 
                485                 490                 495     


Ala Ser Gly Leu Ser Gly Asp Ala Asp Ala Glu Arg Glu Ala Gly Ala 
            500                 505                 510         


Gln Val Met Arg Glu Thr Glu Gln Gln Ile Tyr Arg Gln Leu Thr Asp 
        515                 520                 525             


Glu Val Leu Ala Leu Arg Leu Ser Glu Asn Gly Ser Gln Leu His His 
    530                 535                 540                 


Ser 
545 


<210> 12
<211> 1822
<212> DNA
<213> Shigella flexneri

<400> 12
gttaactgaa acagtatcgt ttttttacag ccaattttgt ttatccttat tataataaaa       60

aagtgctgaa gttcatttca tggaatgaac ttcataaaaa ctcctactta tttcttttaa      120

caaagccatt tgtccaccgg ctttaactgg atgcccatca tgttaccgat aaataataac      180

ttttcattgc cccaaaattc tttttataac actatttccg gtacatatgc tgattacttt      240

tcagcatggg ataaatggga aaaacaagcg ctccccggtg aagagcgtga tgaggctgtc      300

tcccgactta aagaatgtct tatcaataat tccgatgaac ttcgactgga ccgtttaaat      360

ctgtcctcgc tacctgacaa cttaccagct cagataacgc tgctcaatgt atcatataat      420

caattaacta acctacctga actgcctgtt acgctaaaaa aattatattc cgccagcaat      480

aaattatcag aattgcccgt gctacctcct gcgctggagt cacttcaggt acaacacaat      540

gagctggaaa acctgccagc tttacccgat tcgttattga ctatgaatat cagctataac      600

gaaatagtct ccttaccatc gctcccacag gctcttaaaa atctcagagc gacccgtaat      660

ttcctcactg agctaccagc attttctgag ggaaataatc ccgttgtcag agagtatttt      720

tttgatagaa atcagataag tcatatcccg gaaagcattc ttaatctgag gaatgaatgt      780

tcaatacata ttagtgataa cccattatca tcccatgctc tgcaagccct gcaaagatta      840

acctcttcgc cggactacca cggcccacgg atttacttct ccatgagtga cggacaacag      900

aatacactcc atcgccccct ggctgatgcc gtgacagcat ggttcccgga aaacaaacaa      960

tctgatgtat cacagatatg gcatgctttt gaacatgaag agcatgccaa caccttttcc     1020

gcgttccttg accgcctttc cgataccgtc tctgcacgca atacctccgg attccgtgaa     1080

caggtcgctg catggctgga aaaactcagt gcctctgcgg agcttcgaca gcagtctttc     1140

gctgttgctg ctgatgccac tgagagctgt gaggaccgtg tcgcgctcac atggaacaat     1200

ctccggaaaa ccctcctggt ccatcaggca tcagaaggcc ttttcgataa tgataccggc     1260

gctctgctct ccctgggcag ggaaatgttc cgcctcgaaa ttctggagga tattgcccgg     1320

gataaagtca gaactctcca ttttgtggat gagatagaag tctacctggc cttccagacc     1380

atgctcgcag agaaacttca gctctccact gccgtgaagg aaatgcgttt ctatggcgtg     1440

tcgggagtga cagcaaatga cctccgcact gccgaagcca tggtcagaag ccgtgaagag     1500

aatgaattta cggactggtt ctccctctgg ggaccatggc atgctgtact gaagcgtacg     1560

gaagctgacc gctgggcgca ggcagaagag cagaaatatg agatgctgga gaatgagtac     1620

cctcagaggg tggctgaccg gctgaaagca tcaggtctga gcggtgatgc ggatgcggag     1680

agggaagccg gtgcacaggt gatgcgtgag actgaacagc agatttaccg tcagctgact     1740

gacgaggtac tggccctgcg attgtctgaa aacggctcac aactgcacca ttcataatca     1800

catcgcataa aactgtcagc gc                                              1822


<210> 13
<211> 574
<212> PRT
<213> Shigella flexneri

<400> 13
Met Lys Pro Ile Asn Asn His Ser Phe Phe Arg Ser Leu Cys Gly Leu 
1               5                   10                  15      


Ser Cys Ile Ser Arg Leu Ser Val Glu Glu Gln Cys Thr Arg Asp Tyr 
            20                  25                  30          


His Arg Ile Trp Asp Asp Trp Ala Arg Glu Gly Thr Thr Thr Glu Asn 
        35                  40                  45              


Arg Ile Gln Ala Val Arg Leu Leu Lys Ile Cys Leu Asp Thr Arg Glu 
    50                  55                  60                  


Pro Val Leu Asn Leu Ser Leu Leu Lys Leu Arg Ser Leu Pro Pro Leu 
65                  70                  75                  80  


Pro Leu His Ile Arg Glu Leu Asn Ile Ser Asn Asn Glu Leu Ile Ser 
                85                  90                  95      


Leu Pro Glu Asn Ser Pro Leu Leu Thr Glu Leu His Val Asn Gly Asn 
            100                 105                 110         


Asn Leu Asn Ile Leu Pro Thr Leu Pro Ser Gln Leu Ile Lys Leu Asn 
        115                 120                 125             


Ile Ser Phe Asn Arg Asn Leu Ser Cys Leu Pro Ser Leu Pro Pro Tyr 
    130                 135                 140                 


Leu Gln Ser Leu Ser Ala Arg Phe Asn Ser Leu Glu Thr Leu Pro Glu 
145                 150                 155                 160 


Leu Pro Ser Thr Leu Thr Ile Leu Arg Ile Glu Gly Asn Arg Leu Thr 
                165                 170                 175     


Val Leu Pro Glu Leu Pro His Arg Leu Gln Glu Leu Phe Val Ser Gly 
            180                 185                 190         


Asn Arg Leu Gln Glu Leu Pro Glu Phe Pro Gln Ser Leu Lys Tyr Leu 
        195                 200                 205             


Lys Val Gly Glu Asn Gln Leu Arg Arg Leu Ser Arg Leu Pro Gln Glu 
    210                 215                 220                 


Leu Leu Ala Leu Asp Val Ser Asn Asn Leu Leu Thr Ser Leu Pro Glu 
225                 230                 235                 240 


Asn Ile Ile Thr Leu Pro Ile Cys Thr Asn Val Asn Ile Ser Gly Asn 
                245                 250                 255     


Pro Leu Ser Thr His Val Leu Gln Ser Leu Gln Arg Leu Thr Ser Ser 
            260                 265                 270         


Pro Asp Tyr His Gly Pro Gln Ile Tyr Phe Ser Met Ser Asp Gly Gln 
        275                 280                 285             


Gln Asn Thr Leu His Arg Pro Leu Ala Asp Ala Val Thr Ala Trp Phe 
    290                 295                 300                 


Pro Glu Asn Lys Gln Ser Asp Val Ser Gln Ile Trp His Ala Phe Glu 
305                 310                 315                 320 


His Glu Glu His Ala Asn Thr Phe Ser Ala Phe Leu Asp Arg Leu Ser 
                325                 330                 335     


Asp Thr Val Ser Ala Arg Asn Thr Ser Gly Phe Arg Glu Gln Val Ala 
            340                 345                 350         


Ala Trp Leu Glu Lys Leu Ser Ala Ser Ala Glu Leu Arg Gln Gln Ser 
        355                 360                 365             


Phe Ala Val Ala Ala Asp Ala Thr Glu Ser Cys Glu Asp Arg Val Ala 
    370                 375                 380                 


Leu Thr Trp Asn Asn Leu Arg Lys Thr Leu Leu Val His Gln Ala Ser 
385                 390                 395                 400 


Glu Gly Leu Phe Asp Asn Asp Thr Gly Ala Leu Leu Ser Leu Gly Arg 
                405                 410                 415     


Glu Met Phe Arg Leu Glu Ile Leu Glu Asp Ile Ala Arg Asp Lys Val 
            420                 425                 430         


Arg Thr Leu His Phe Val Asp Glu Ile Glu Val Tyr Leu Ala Phe Gln 
        435                 440                 445             


Thr Met Leu Ala Glu Lys Leu Gln Leu Ser Thr Ala Val Lys Glu Met 
    450                 455                 460                 


Arg Phe Tyr Gly Val Ser Gly Val Thr Ala Asn Asp Leu Arg Thr Ala 
465                 470                 475                 480 


Glu Ala Met Val Arg Ser Arg Glu Glu Asn Glu Phe Thr Asp Trp Phe 
                485                 490                 495     


Ser Leu Trp Gly Pro Trp His Ala Val Leu Lys Arg Thr Glu Ala Asp 
            500                 505                 510         


Arg Trp Ala Gln Ala Glu Glu Gln Lys Tyr Glu Met Leu Glu Asn Glu 
        515                 520                 525             


Tyr Ser Gln Arg Val Ala Asp Arg Leu Lys Ala Ser Gly Leu Ser Gly 
    530                 535                 540                 


Asp Ala Asp Ala Glu Arg Glu Ala Gly Ala Gln Val Met Arg Glu Thr 
545                 550                 555                 560 


Glu Gln Gln Ile Tyr Arg Gln Leu Thr Asp Glu Val Leu Ala 
                565                 570                 


<210> 14
<211> 1725
<212> DNA
<213> Shigella flexneri

<400> 14
atgaaaccga tcaacaatca ttcttttttt cgttcccttt gtggcttatc atgtatatct       60

cgtttatcgg tagaagaaca gtgtaccaga gattaccacc gcatctggga tgactgggct      120

agggaaggaa caacaacaga aaatcgcatc caggcggttc gattattgaa aatatgtctg      180

gatacccggg agcctgttct caatttaagc ttactgaaac tacgttcttt accaccactc      240

cctttgcata tacgtgaact taatatttcc aacaatgagt taatctccct acctgaaaat      300

tctccgcttt tgacagaact tcatgtaaat ggtaacaact tgaatatact cccgacactt      360

ccatctcaac tgattaagct taatatttca ttcaatcgaa atttgtcatg tctgccatca      420

ttaccaccat atttacaatc actctcggca cgttttaata gtctggagac gttaccagag      480

cttccatcaa cgctaacaat attacgtatt gaaggtaatc gccttactgt cttgcctgaa      540

ttgcctcata gactacaaga actctttgtt tccggcaaca gactacagga actaccagaa      600

tttcctcaga gcttaaaata tttgaaggta ggtgaaaatc aactacgcag attatccaga      660

ttaccgcaag aactattggc actggatgtt tccaataacc tactaacttc attacccgaa      720

aatataatca cattgcccat ttgtacgaat gttaacattt cagggaatcc attgtcgact      780

cacgttctgc aatccctgca aagattaacc tcttcgccgg actaccacgg cccgcagatt      840

tacttctcca tgagtgacgg acaacagaat acactccatc gccccctggc tgatgccgtg      900

acagcatggt tcccggaaaa caaacaatct gatgtatcac agatatggca tgcttttgaa      960

catgaagagc atgccaacac cttttccgcg ttccttgacc gcctttccga taccgtctct     1020

gcacgcaata cctccggatt ccgtgaacag gtcgctgcat ggctggaaaa actcagtgcc     1080

tctgcggagc ttcgacagca gtctttcgct gttgctgctg atgccactga gagctgtgag     1140

gaccgtgtcg cgctcacatg gaacaatctc cggaaaaccc tcctggtcca tcaggcatca     1200

gaaggccttt tcgataatga taccggcgct ctgctctccc tgggcaggga aatgttccgc     1260

ctcgaaattc tggaggatat tgcccgggat aaagtcagaa ctctccattt tgtggatgag     1320

atagaagtct acctggcctt ccagaccatg ctcgcagaga aacttcagct ctccactgcc     1380

gtgaaggaaa tgcgtttcta tggcgtgtcg ggagtgacag caaatgacct ccgcactgcc     1440

gaagctatgg tcagaagccg tgaagagaat gaatttacgg actggttctc cctctgggga     1500

ccatggcatg ctgtactgaa gcgtacggaa gctgaccgct gggcgcaggc agaagagcag     1560

aagtatgaga tgctggagaa tgagtactct cagagggtgg ctgaccggct gaaagcatca     1620

ggtctgagcg gtgatgcgga tgcggagagg gaagccggtg cacaggtgat gcgtgagact     1680

gaacagcaga tttaccgtca gttgactgac gaggtactgg cctga                     1725


<210> 15
<211> 367
<212> PRT
<213> Yersinia pestis

<400> 15
Met Phe Ile Thr Pro Arg Asn Val Ser Asn Thr Phe Leu Gln Glu Pro 
1               5                   10                  15      


Leu Arg His Ser Ser Asp Leu Thr Glu Met Pro Val Glu Ala Glu Asn 
            20                  25                  30          


Val Lys Ser Lys Thr Glu Tyr Tyr Asn Ala Trp Ala Val Trp Glu Arg 
        35                  40                  45              


Asn Ala Pro Pro Gly Asn Gly Glu Gln Arg Glu Met Ala Val Ser Arg 
    50                  55                  60                  


Leu Arg Asp Cys Leu Asp Arg Gln Ala His Glu Leu Glu Leu Asn Asn 
65                  70                  75                  80  


Leu Gly Leu Ser Ser Leu Pro Glu Leu Pro Pro His Leu Glu Ser Leu 
                85                  90                  95      


Val Ala Ser Cys Asn Ser Leu Thr Glu Leu Pro Glu Leu Pro Gln Ser 
            100                 105                 110         


Leu Lys Ser Leu Gln Val Asp Asn Asn Asn Leu Lys Ala Leu Ser Asp 
        115                 120                 125             


Leu Pro Pro Ser Leu Glu Phe Leu Ala Ala Gly Asn Asn Gln Leu Glu 
    130                 135                 140                 


Glu Leu Pro Glu Leu Gln Asn Ser Ser Phe Leu Lys Ile Ile Asp Val 
145                 150                 155                 160 


Asp Asn Asn Ser Leu Lys Lys Leu Pro Asp Leu Pro Pro Ser Leu Glu 
                165                 170                 175     


Phe Leu Ala Ala Gly Asn Asn Gln Leu Glu Glu Leu Ser Glu Leu Gln 
            180                 185                 190         


Asn Leu Pro Phe Leu Thr Glu Ile His Ala Asp Asn Asn Ser Leu Lys 
        195                 200                 205             


Thr Leu Pro Asp Leu Pro Pro Ser Leu Lys Thr Leu Asn Val Arg Glu 
    210                 215                 220                 


Asn Tyr Leu Thr Asp Leu Pro Glu Leu Pro Gln Ser Leu Thr Phe Leu 
225                 230                 235                 240 


Asp Val Ser Asp Asn Ile Phe Ser Gly Leu Ser Glu Leu Pro Pro Asn 
                245                 250                 255     


Leu Tyr Tyr Leu Asp Ala Ser Ser Asn Gly Ile Arg Ser Leu Cys Asp 
            260                 265                 270         


Leu Pro Pro Ser Leu Val Glu Leu Asp Val Arg Asp Asn Gln Leu Ile 
        275                 280                 285             


Glu Leu Pro Ala Leu Pro Pro His Leu Glu Arg Leu Ile Ala Ser Leu 
    290                 295                 300                 


Asn His Leu Ala Glu Val Pro Glu Leu Pro Gln Asn Leu Lys Gln Leu 
305                 310                 315                 320 


His Val Glu His Asn Ala Leu Arg Glu Phe Pro Asp Ile Pro Glu Ser 
                325                 330                 335     


Val Glu Asp Leu Arg Met Asp Ser Glu Arg Val Thr Asp Thr Tyr Glu 
            340                 345                 350         


Phe Ala His Glu Thr Thr Asp Lys Leu Glu Asp Asp Val Phe Glu 
        355                 360                 365         


<210> 16
<211> 1104
<212> DNA
<213> Yersinia pestis

<400> 16
atgtttataa ctccaagaaa tgtatctaat acttttttgc aagaaccatt acgtcattct       60

tctgatttaa ctgagatgcc ggttgaagca gaaaatgtta aatctaagac tgaatattat      120

aatgcatggg cggtatggga acgaaatgcc cctccgggga atggtgaaca gagggaaatg      180

gcggtttcaa ggttacgcga ttgcctggac cgacaagccc atgagctaga actaaataat      240

ctggggctga gttctttgcc ggaattacct ccgcatttag agagtttagt ggcgtcatgt      300

aattctctta cagaattacc ggaattgccg cagagcctga aatcacttca agttgataat      360

aacaatctga aggcattatc cgatttacct ccttcactgg aatttcttgc tgctggtaat      420

aatcagctgg aagaattgcc agagttgcaa aactcgtcct tcttgaaaat tattgatgtt      480

gataacaatt cactgaaaaa actacctgat ttacctcctt cactggaatt tcttgctgct      540

ggtaataatc agctggaaga attgtcagag ttacaaaact tgccattctt gactgagatt      600

catgctgata acaattcact gaaaacatta cccgatttac ccccttccct gaaaacactt      660

aatgtcagag aaaattattt aactgatctg ccagaattac cgcagagttt aaccttctta      720

gatgtttctg ataatatttt ttctggatta tcggaattgc caccaaactt gtattatctc      780

gatgcatcca gcaatggaat aagatcctta tgcgatttac ccccttcact ggtagaactt      840

gatgtcagag ataatcagtt gatcgaactg ccagcgttac ctccacactt agaacgttta      900

atcgcttcac ttaatcatct tgctgaagta cctgaattgc cgcaaaacct gaaacagctc      960

cacgtagagc acaacgctct aagagagttt cccgatatac ctgagtcagt ggaagatctt     1020

cggatggact ctgaacgtgt aactgataca tatgaatttg ctcatgagac tacagacaaa     1080

cttgaagatg atgtatttga gtag                                            1104


<210> 17
<211> 86
<212> PRT
<213> Yersinia pestis

<400> 17
Met Phe Ile Asn Pro Arg Asn Val Ser Asn Thr Phe Leu Gln Glu Pro 
1               5                   10                  15      


Leu Arg His Ser Ser Asn Leu Thr Glu Met Pro Val Glu Ala Glu Asn 
            20                  25                  30          


Val Lys Ser Lys Thr Glu Tyr Tyr Asn Ala Trp Ser Glu Trp Glu Arg 
        35                  40                  45              


Asn Ala Pro Pro Gly Asn Gly Glu Gln Arg Glu Met Ala Val Ser Arg 
    50                  55                  60                  


Leu Arg Asp Cys Leu Asp Arg Gln Ala His Glu Leu Glu Leu Asn Asn 
65                  70                  75                  80  


Leu Gly Leu Ser Ser Leu 
                85      


<210> 18
<211> 258
<212> DNA
<213> Yersinia pestis

<400> 18
atgttcatca ctccacgcaa tgtatctaac acctttctgc aggaaccgct gcgtcattct       60

agcgacctga ccgaaatgcc agttgaagcg gagaacgtga aatctaagac tgaatactac      120

aacgcgtggg cagtatggga gcgcaatgca ccaccaggta acggtgaaca gcgtgaaatg      180

gcagtaagcc gtctgcgtga ttgcctggat cgccaggctc acgagctgga gctgaacaac      240

ctgggtctgt ctagcctg                                                    258


<210> 19
<211> 131
<212> PRT
<213> Yersinia pestis

<400> 19
Met Phe Ile Asn Pro Arg Asn Val Ser Asn Thr Phe Leu Gln Glu Pro 
1               5                   10                  15      


Leu Arg His Ser Ser Asn Leu Thr Glu Met Pro Val Glu Ala Glu Asn 
            20                  25                  30          


Val Lys Ser Lys Thr Glu Tyr Tyr Asn Ala Trp Ser Glu Trp Glu Arg 
        35                  40                  45              


Asn Ala Pro Pro Gly Asn Gly Glu Gln Arg Glu Met Ala Val Ser Arg 
    50                  55                  60                  


Leu Arg Asp Cys Leu Asp Arg Gln Ala His Glu Leu Glu Leu Asn Asn 
65                  70                  75                  80  


Leu Gly Leu Ser Ser Leu Pro Glu Leu Pro Pro His Leu Glu Ser Leu 
                85                  90                  95      


Val Ala Ser Cys Asn Ser Leu Thr Glu Leu Pro Glu Leu Pro Gln Ser 
            100                 105                 110         


Leu Lys Ser Leu Leu Val Asp Asn Asn Asn Leu Lys Ala Leu Ser Asp 
        115                 120                 125             


Leu Pro Pro 
    130     


<210> 20
<211> 393
<212> DNA
<213> Yersinia pestis

<400> 20
atgtttatta acccgcgcaa cgtgagcaac acctttctgc aggaaccgct gcgccatagc       60

agcaacctga ccgaaatgcc ggtggaagcg gaaaacgtga aaagcaaaac cgaatattat      120

aacgcgtgga gcgaatggga acgcaacgcg ccgccgggca acggcgaaca gcgcgaaatg      180

gcggtgagcc gcctgcgcga ttgcctggat cgccaggcgc atgaactgga actgaacaac      240

ctgggcctga gcagcctgcc ggaactgccg ccgcatctgg aaagcctggt ggcgagctgc      300

aacagcctga ccgaactgcc ggaactgccg cagagcctga aaagcctgct ggtggataac      360

aacaacctga aagcgctgag cgatctgccg ccg                                   393


<210> 21
<211> 565
<212> PRT
<213> Shigella flexneri

<400> 21
Met Phe Ser Val Asn Asn Thr His Ser Ser Val Ser Cys Ser Pro Ser 
1               5                   10                  15      


Ile Asn Ser Asn Ser Thr Ser Asn Glu His Tyr Leu Arg Ile Leu Thr 
            20                  25                  30          


Glu Trp Glu Lys Asn Ser Ser Pro Gly Glu Glu Arg Gly Ile Ala Phe 
        35                  40                  45              


Asn Arg Leu Ser Gln Cys Phe Gln Asn Gln Glu Ala Val Leu Asn Leu 
    50                  55                  60                  


Ser Asp Leu Asn Leu Thr Ser Leu Pro Glu Leu Pro Lys His Ile Ser 
65                  70                  75                  80  


Ala Leu Ile Val Glu Asn Asn Lys Leu Thr Ser Leu Pro Lys Leu Pro 
                85                  90                  95      


Ala Phe Leu Lys Glu Leu Asn Ala Asp Asn Asn Arg Leu Ser Val Ile 
            100                 105                 110         


Pro Glu Leu Pro Glu Ser Leu Thr Thr Leu Ser Val Arg Ser Asn Gln 
        115                 120                 125             


Leu Glu Asn Leu Pro Val Leu Pro Asn His Leu Thr Ser Leu Phe Val 
    130                 135                 140                 


Glu Asn Asn Arg Leu Tyr Asn Leu Pro Ala Leu Pro Glu Lys Leu Lys 
145                 150                 155                 160 


Phe Leu His Val Tyr Tyr Asn Arg Leu Thr Thr Leu Pro Asp Leu Pro 
                165                 170                 175     


Asp Lys Leu Glu Ile Leu Cys Ala Gln Arg Asn Asn Leu Val Thr Phe 
            180                 185                 190         


Pro Gln Phe Ser Asp Arg Asn Asn Ile Arg Gln Lys Glu Tyr Tyr Phe 
        195                 200                 205             


His Phe Asn Gln Ile Thr Thr Leu Pro Glu Ser Phe Ser Gln Leu Asp 
    210                 215                 220                 


Ser Ser Tyr Arg Ile Asn Ile Ser Gly Asn Pro Leu Ser Thr Arg Val 
225                 230                 235                 240 


Leu Gln Ser Leu Gln Arg Leu Thr Ser Ser Pro Asp Tyr His Gly Pro 
                245                 250                 255     


Gln Ile Tyr Phe Ser Met Ser Asp Gly Gln Gln Asn Thr Leu His Arg 
            260                 265                 270         


Pro Leu Ala Asp Ala Val Thr Ala Trp Phe Pro Glu Asn Lys Gln Ser 
        275                 280                 285             


Asp Val Ser Gln Ile Trp His Ala Phe Glu His Glu Glu His Ala Asn 
    290                 295                 300                 


Thr Phe Ser Ala Phe Leu Asp Arg Leu Ser Asp Thr Val Ser Ala Arg 
305                 310                 315                 320 


Asn Thr Ser Gly Phe Arg Glu Gln Val Ala Ala Trp Leu Glu Lys Leu 
                325                 330                 335     


Ser Ala Ser Ala Glu Leu Arg Gln Gln Ser Phe Ala Val Ala Ala Asp 
            340                 345                 350         


Ala Thr Glu Ser Cys Glu Asp Arg Val Ala Leu Thr Trp Asn Asn Leu 
        355                 360                 365             


Arg Lys Thr Leu Leu Val His Gln Ala Ser Glu Gly Leu Phe Asp Asn 
    370                 375                 380                 


Asp Thr Gly Ala Leu Leu Ser Leu Gly Arg Glu Met Phe Arg Leu Glu 
385                 390                 395                 400 


Ile Leu Glu Asp Ile Ala Arg Asp Lys Val Arg Thr Leu His Phe Val 
                405                 410                 415     


Asp Glu Ile Glu Val Tyr Leu Ala Phe Gln Thr Met Leu Ala Glu Lys 
            420                 425                 430         


Leu Gln Leu Ser Thr Ala Val Lys Glu Met Arg Phe Tyr Gly Val Ser 
        435                 440                 445             


Gly Val Thr Ala Asn Asp Leu Arg Thr Ala Glu Ala Met Val Arg Ser 
    450                 455                 460                 


Arg Glu Glu Asn Glu Phe Thr Asp Trp Phe Ser Leu Trp Gly Pro Trp 
465                 470                 475                 480 


His Ala Val Leu Lys Arg Thr Glu Ala Asp Arg Trp Ala Gln Ala Glu 
                485                 490                 495     


Glu Gln Lys Tyr Glu Met Leu Glu Asn Glu Tyr Ser Gln Arg Val Ala 
            500                 505                 510         


Asp Arg Leu Lys Ala Ser Gly Leu Ser Gly Asp Ala Asp Ala Glu Arg 
        515                 520                 525             


Glu Ala Gly Ala Gln Val Met Arg Glu Thr Glu Gln Gln Ile Tyr Arg 
    530                 535                 540                 


Gln Leu Thr Asp Glu Val Leu Ala Leu Arg Leu Ser Glu Asn Gly Ser 
545                 550                 555                 560 


Arg Leu His His Ser 
                565 


<210> 22
<211> 1698
<212> DNA
<213> Shigella flexneri

<400> 22
atgttctctg taaataatac acactcatca gtttcttgct ccccctctat taactcaaac       60

tcaaccagta atgaacatta tctgagaatc ctgactgaat gggaaaagaa ctcttctccc      120

ggggaagagc gaggcattgc ttttaacaga ctctcccagt gctttcagaa tcaagaagca      180

gtattaaatt tatcagacct aaatttgacg tctcttcccg aattaccaaa gcatatttct      240

gctttgattg tagaaaataa taaattaaca tcattgccaa agctgcctgc atttcttaaa      300

gaacttaatg ctgataataa caggctttct gtgataccag aacttcctga gtcattaaca      360

actttaagtg ttcgttctaa tcaactggaa aaccttcctg ttttgccaaa ccatttaaca      420

tcattatttg ttgaaaataa caggctatat aacttaccgg ctcttcccga aaaattgaaa      480

tttttacatg tttattataa caggctgaca acattacccg acttaccgga taaactggaa      540

attctctgtg ctcagcgcaa taatctggtt acttttcctc aattttctga tagaaacaat      600

atcagacaaa aggaatatta ttttcatttt aatcagataa ccactcttcc ggagagtttt      660

tcacaattag attcaagtta caggattaat atttcaggga atccattgtc gactcgcgtt      720

ctgcaatccc tgcaaagatt aacctcttcg ccggactacc acggcccgca gatttacttc      780

tccatgagtg acggacaaca gaatacactc catcgccccc tggctgatgc cgtgacagca      840

tggttcccgg aaaacaaaca atctgatgta tcacagatat ggcatgcttt tgaacatgaa      900

gagcatgcca acaccttttc cgcgttcctt gaccgccttt ccgataccgt ctctgcacgc      960

aatacctccg gattccgtga acaggtcgct gcatggctgg aaaaactcag tgcctctgcg     1020

gagcttcgac agcagtcttt cgctgttgct gctgatgcca ctgagagctg tgaggaccgt     1080

gtcgcgctca catggaacaa tctccggaaa accctcctgg tccatcaggc atcagaaggc     1140

cttttcgata atgataccgg cgctctgctc tccctgggca gggaaatgtt ccgcctcgaa     1200

attctggagg acattgcccg ggataaagtc agaactctcc attttgtgga tgagatagaa     1260

gtctacctgg ccttccagac catgctcgca gagaaacttc agctctccac tgccgtgaag     1320

gaaatgcgtt tctatggcgt gtcgggagtg acagcaaatg acctccgcac tgccgaagct     1380

atggtcagaa gccgtgaaga gaatgaattt acggactggt tctccctctg gggaccatgg     1440

catgctgtac tgaagcgtac ggaagctgac cgctgggcgc aggcagaaga gcagaagtat     1500

gagatgctgg agaatgagta ctctcagagg gtggctgacc ggctgaaagc atcaggtctg     1560

agcggtgatg cggatgcgga gagggaagcc ggtgcacagg tgatgcgtga gactgaacag     1620

cagatttacc gtcagctgac tgacgaggta ctggccctgc gattgtctga aaacggctca     1680

cgactgcacc attcataa                                                   1698


<210> 23
<211> 379
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Met Phe Ile Thr Pro Arg Asn Val Ser Asn Thr Phe Leu Gln Glu Pro 
1               5                   10                  15      


Leu Arg His Ser Ser Asp Leu Thr Glu Met Pro Val Glu Ala Glu Asn 
            20                  25                  30          


Val Lys Ser Lys Thr Glu Tyr Tyr Asn Ala Trp Ala Val Trp Glu Arg 
        35                  40                  45              


Asn Ala Pro Pro Gly Asn Gly Glu Gln Arg Glu Met Ala Val Ser Arg 
    50                  55                  60                  


Leu Arg Asp Cys Leu Asp Arg Gln Ala His Glu Leu Glu Leu Asn Asn 
65                  70                  75                  80  


Leu Gly Leu Ser Ser Leu Pro Glu Leu Pro Pro His Leu Glu Ser Leu 
                85                  90                  95      


Val Ala Ser Cys Asn Ser Leu Thr Glu Leu Pro Glu Leu Pro Gln Ser 
            100                 105                 110         


Leu Lys Ser Leu Gln Val Asp Asn Asn Asn Leu Lys Ala Leu Ser Asp 
        115                 120                 125             


Leu Pro Pro Ser Leu Glu Phe Leu Ala Ala Gly Asn Asn Gln Leu Glu 
    130                 135                 140                 


Glu Leu Pro Glu Leu Gln Asn Ser Ser Phe Leu Lys Ile Ile Asp Met 
145                 150                 155                 160 


Ser Ile Glu Ile Lys Met Ile Ser Pro Ile Lys Asn Ile Lys Asn Val 
                165                 170                 175     


Phe Pro Ile Asn Thr Ala Asn Thr Glu Tyr Ile Val Arg Asn Ile Tyr 
            180                 185                 190         


Pro Arg Val Glu His Gly Tyr Phe Asn Glu Ser Pro Asn Ile Tyr Asp 
        195                 200                 205             


Lys Lys Tyr Ile Ser Gly Ile Thr Arg Ser Met Ala Gln Leu Lys Ile 
    210                 215                 220                 


Glu Glu Phe Ile Asn Glu Lys Ser Arg Arg Leu Asn Tyr Met Lys Thr 
225                 230                 235                 240 


Met Tyr Ser Pro Cys Pro Glu Asp Phe Gln Pro Ile Ser Arg Asp Glu 
                245                 250                 255     


Ala Ser Thr Pro Glu Gly Ser Trp Leu Thr Val Ile Ser Gly Lys Arg 
            260                 265                 270         


Pro Met Gly Gln Phe Ser Val Asp Ser Leu Tyr His Pro Asp Leu His 
        275                 280                 285             


Ala Leu Cys Glu Leu Pro Glu Ile Ser Cys Lys Ile Phe Pro Lys Glu 
    290                 295                 300                 


Asn Ser Asp Phe Leu Tyr Ile Ile Val Val Phe Arg Asn Asp Ser Pro 
305                 310                 315                 320 


Gln Gly Glu Leu Arg Ala Asn Arg Phe Ile Glu Leu Tyr Asp Ile Lys 
                325                 330                 335     


Arg Glu Ile Met Gln Val Leu Arg Asp Glu Ser Pro Glu Leu Lys Ser 
            340                 345                 350         


Ile Lys Ser Glu Ile Ile Ile Ala Arg Glu Met Gly Glu Leu Phe Ser 
        355                 360                 365             


Tyr Ala Ser Glu Glu Ile Asp Ser Tyr Ile Lys 
    370                 375                 


<210> 24
<211> 345
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Phe Ile Thr Pro Arg Asn Val Ser Asn Thr Phe Leu Gln Glu Pro 
1               5                   10                  15      


Leu Arg His Ser Ser Asp Leu Thr Glu Met Pro Val Glu Ala Glu Asn 
            20                  25                  30          


Val Lys Ser Lys Thr Glu Tyr Tyr Asn Ala Trp Ala Val Trp Glu Arg 
        35                  40                  45              


Asn Ala Pro Pro Gly Asn Gly Glu Gln Arg Glu Met Ala Val Ser Arg 
    50                  55                  60                  


Leu Arg Asp Cys Leu Asp Arg Gln Ala His Glu Leu Glu Leu Asn Asn 
65                  70                  75                  80  


Leu Gly Leu Ser Ser Leu Pro Glu Leu Pro Pro His Leu Glu Ser Leu 
                85                  90                  95      


Val Ala Ser Cys Asn Ser Leu Thr Glu Leu Pro Glu Leu Pro Gln Ser 
            100                 105                 110         


Leu Lys Ser Leu Gln Val Asp Asn Asn Asn Leu Lys Ala Leu Ser Asp 
        115                 120                 125             


Leu Pro Pro Ser Leu Glu Phe Leu Ala Ala Gly Asn Asn Gln Leu Glu 
    130                 135                 140                 


Glu Leu Pro Glu Leu Gln Asn Ser Ser Phe Leu Lys Ile Ile Asp Lys 
145                 150                 155                 160 


Ile Pro Ser Leu Gln Ser Asn Phe Asn Phe Ser Ala Pro Ala Gly Tyr 
                165                 170                 175     


Ser Ala Pro Ile Ala Pro Asn Arg Ala Glu Asn Ala Tyr Ala Asp Tyr 
            180                 185                 190         


Val Leu Asp Ile Gly Lys Arg Ile Pro Leu Ser Ala Ala Asp Leu Ser 
        195                 200                 205             


Asn Val Tyr Glu Ser Val Ile Arg Ala Val His Asp Ser Arg Ser Arg 
    210                 215                 220                 


Leu Ile Asp Gln His Thr Val Asp Met Ile Gly Asn Thr Val Leu Asp 
225                 230                 235                 240 


Ala Leu Ser Arg Ser Gln Thr Phe Arg Asp Ala Val Ser Tyr Gly Ile 
                245                 250                 255     


His Asn Glu Lys Val His Ile Gly Cys Ile Lys Tyr Arg Asn Glu Tyr 
            260                 265                 270         


Glu Leu Asn Glu Glu Ser Ser Val Lys Ile Asp Asp Ile Gln Ser Leu 
        275                 280                 285             


Thr Cys Asn Glu Leu Tyr Glu Tyr Asp Val Gly Gln Glu Pro Ile Phe 
    290                 295                 300                 


Pro Ile Cys Glu Ala Gly Glu Asn Asp Asn Glu Glu Pro Tyr Val Ser 
305                 310                 315                 320 


Phe Ser Val Ala Pro Asp Thr Asp Ser Tyr Glu Met Pro Ser Trp Gln 
                325                 330                 335     


Glu Gly Leu Ile His Glu Ile Ile His 
            340                 345 


<210> 25
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(30)
<223> This sequence may encompass 1-6 "Gly Gly Gly Gly Ser"
      repeating units

<400> 25
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210> 26
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(4)
<223> Thr or Ser

<220>
<221> MOD_RES
<222> (6)..(9)
<223> Thr or Ser

<220>
<221> MOD_RES
<222> (11)..(14)
<223> Thr or Ser

<220>
<221> MOD_RES
<222> (16)..(19)
<223> Thr or Ser

<220>
<221> MOD_RES
<222> (21)..(24)
<223> Thr or Ser

<220>
<221> MISC_FEATURE
<222> (1)..(25)
<223> This sequence may encompass 1-5 "Xaa Xaa Xaa Xaa Gly"
      repeating units, wherein Xaa may be Thr or Ser

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 26
Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Gly Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Gly 
            20                  25  


<210> 27
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Ser Ser Ser Ser Gly 
1               5   


<210> 28
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Pro Ala Pro Ala Pro 
1               5   


<210> 29
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (1)..(14)
<223> This region may encompass 2-7 "Pro Thr"
      repeating units

<400> 29
Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro 
1               5                   10                  15  


<210> 30
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (2)..(26)
<223> This region may encompass 1-5 "Glu Ala Ala Ala Lys"
      repeating units

<400> 30
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
            20                  25          


