                         SEQUENCE LISTING

<110>  University of Washington
 
<120>  METHODS AND COMPOSITIONS FOR REPROGRAMMING MULLER GLIA

<130>  UW70WOU1

<150>  62/840,264
<151>  2019-04-28

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  2843
<212>  DNA
<213>  Homo sapiens

<400>  1
agcactctct cacttctggc cagggaacgt ggaaggcgca ccgacaggga tccggccagg       60

gagggcgagt gaaagaagga aatcagaaag gaagggagtt aacaaaataa taaaaacagc      120

ctgagccacg gctggagaga ccgagacccg gcgcaagaga gcgcagcctt agtaggagag      180

gaacgcgaga cgcggcagag cgcgttcagc actgactttt gctgctgctt ctgctttttt      240

ttttcttaga aacaagaagg cgccagcggc agcctcacac gcgagcgcca cgcgaggctc      300

ccgaagccaa cccgcgaagg gaggagggga gggaggagga ggcggcgtgc agggaggaga      360

aaaagcattt tcactttttt tgctcccact ctaagaagtc tcccggggat tttgtatata      420

ttttttaact tccgtcaggg ctcccgcttc atatttcctt ttctttccct ctctgttcct      480

gcacccaagt tctctctgtg tccccctcgc gggccccgca cctcgcgtcc cggatcgctc      540

tgattccgcg actccttggc cgccgctgcg catggaaagc tctgccaaga tggagagcgg      600

cggcgccggc cagcagcccc agccgcagcc ccagcagccc ttcctgccgc ccgcagcctg      660

tttctttgcc acggccgcag ccgcggcggc cgcagccgcc gcagcggcag cgcagagcgc      720

gcagcagcag cagcagcagc agcagcagca gcagcaggcg ccgcagctga gaccggcggc      780

cgacggccag ccctcagggg gcggtcacaa gtcagcgccc aagcaagtca agcgacagcg      840

ctcgtcttcg cccgaactga tgcgctgcaa acgccggctc aacttcagcg gctttggcta      900

cagcctgccg cagcagcagc cggccgccgt ggcgcgccgc aacgagcgcg agcgcaaccg      960

cgtcaagttg gtcaacctgg gctttgccac ccttcgggag cacgtcccca acggcgcggc     1020

caacaagaag atgagtaagg tggagacact gcgctcggcg gtcgagtaca tccgcgcgct     1080

gcagcagctg ctggacgagc atgacgcggt gagcgccgcc ttccaggcag gcgtcctgtc     1140

gcccaccatc tcccccaact actccaacga cttgaactcc atggccggct cgccggtctc     1200

atcctactcg tcggacgagg gctcttacga cccgctcagc cccgaggagc aggagcttct     1260

cgacttcacc aactggttct gaggggctcg gcctggtcag gccctggtgc gaatggactt     1320

tggaagcagg taggttgcat tttggggtgg gcaggggggt attcttgcct tcgtcctccc     1380

tctgagtgtc tgtggaagtg gggatgtctc caaggagata aggggatttt tatttaaaga     1440

atttgtgaaa gttggtcgat ttcaagtcct agtttgttag tttcagcact ggcctctgaa     1500

aatggccttg cccaggtctc caaggagtga agggtagtag tgaggtgcag agatactggt     1560

gaaccgaata ctgggacatg ttaaaagaga tgtctacctg acagactctt tccccagacc     1620

tccatctccc tctaccacta gcctacacgt tcaaattaac ctctcctgtt cttttcctta     1680

tgttataggg tgatcgcaca acctgcatct ttagtgcttt cttgtcagtg gcgttgggag     1740

ggggagaaaa ggaaaagaaa aaaaaaagaa gaagaagaag aaaagagaag aagaaaaaaa     1800

cgaaaacagt caaccaaccc catcgccaac taagcgaggc atgcctgaga gacatggctt     1860

tcagaaaacg ggaagcgctc agaacagtat ctttgcactc caatcattca cggagatatg     1920

aagagcaact gggacctgag tcaatgcgca aaatgcagct tgtgtgcaaa agcagtgggc     1980

tcctggcaga agggagcagc acacgcgtta tagtaactcc catcacctct aacacgcaca     2040

gctgaaagtt cttgctcggg tcccttcacc tcctcgccct ttcttaaagt gcagttctta     2100

gccctctaga aacgagttgg tgtctttcgt ctcagtagcc cccaccccaa taagctgtag     2160

acattggttt acagtgaaac tatgctattc tcagcccttt gaaactctgc ttctcctcca     2220

gggcccgatt cccaaacccc atggcttccc tcacactgtc ttttctacca ttttcattat     2280

agaatgcttc caatcttttg tgaatttttt attataaaaa atctatttgt atctatccta     2340

accagttcgg ggatatatta agatattttt gtacataaga gagaaagaga gagaaaaatt     2400

tatagaagtt ttgtacaaat ggtttaaaat gtgtatatct tgatacttta acatgtaatg     2460

ctattacctc tgcatatttt agatgtgtag ttcaccttac aactgcaatt ttccctatgt     2520

ggttttgtaa agaactctcc tcataggtga gatcaagagg ccaccagttg tacttcagca     2580

ccaatgtgtc ttactttata gaaatgttgt taatgtatta atgatgttat taaatactgt     2640

tcaagaagaa caaagtttat gcagctactg tccaaactca aagtggcagc cagttggttt     2700

tgataggttg ccttttggag atttctatta ctgccttttt ttttcttact gttttattac     2760

aaacttacaa aaatatgtat aaccctgttt tatacaaact agtttcgtaa taaaactttt     2820

tccttttttt aaaatgaaaa taa                                             2843


<210>  2
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Ser Ser Ala Lys Met Glu Ser Gly Gly Ala Gly Gln Gln Pro 
1               5                   10                  15      


Gln Pro Gln Pro Gln Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe 
            20                  25                  30          


Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln 
        35                  40                  45              


Ser Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Pro 
    50                  55                  60                  


Gln Leu Arg Pro Ala Ala Asp Gly Gln Pro Ser Gly Gly Gly His Lys 
65                  70                  75                  80  


Ser Ala Pro Lys Gln Val Lys Arg Gln Arg Ser Ser Ser Pro Glu Leu 
                85                  90                  95      


Met Arg Cys Lys Arg Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu 
            100                 105                 110         


Pro Gln Gln Gln Pro Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg 
        115                 120                 125             


Asn Arg Val Lys Leu Val Asn Leu Gly Phe Ala Thr Leu Arg Glu His 
    130                 135                 140                 


Val Pro Asn Gly Ala Ala Asn Lys Lys Met Ser Lys Val Glu Thr Leu 
145                 150                 155                 160 


Arg Ser Ala Val Glu Tyr Ile Arg Ala Leu Gln Gln Leu Leu Asp Glu 
                165                 170                 175     


His Asp Ala Val Ser Ala Ala Phe Gln Ala Gly Val Leu Ser Pro Thr 
            180                 185                 190         


Ile Ser Pro Asn Tyr Ser Asn Asp Leu Asn Ser Met Ala Gly Ser Pro 
        195                 200                 205             


Val Ser Ser Tyr Ser Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ser Pro 
    210                 215                 220                 


Glu Glu Gln Glu Leu Leu Asp Phe Thr Asn Trp Phe 
225                 230                 235     


<210>  3
<211>  1065
<212>  DNA
<213>  Homo sapiens

<400>  3
atgtcccgcc tgctgcatgc agaagagtgg gctgaagtga aggagttggg agaccaccat       60

cgccagcccc agccgcatca tctcccgcaa ccgccgccgc cgccgcagcc acctgcaact      120

ttgcaggcga gagagcatcc cgtctacccg cctgagctgt ccctcctgga cagcaccgac      180

ccacgcgcct ggctggctcc cactttgcag ggcatctgca cggcacgcgc cgcccagtat      240

ttgctacatt ccccggagct gggtgcctca gaggccgctg cgccccggga cgaggtggac      300

ggccgggggg agctggtaag gaggagcagc ggcggtgcca gcagcagcaa gagccccggg      360

ccggtgaaag tgcgggaaca gctgtgcaag ctgaaaggcg gggtggtggt agacgagctg      420

ggctgcagcc gccaacgggc cccttccagc aaacaggtga atggggtgca gaagcagaga      480

cggctagcag ccaacgccag ggagcggcgc aggatgcatg ggctgaacca cgccttcgac      540

cagctgcgca atgttatccc gtcgttcaac aacgacaaga agctgtccaa atatgagacc      600

ctgcagatgg cccaaatcta catcaacgcc ttgtccgagc tgctacaaac gcccagcgga      660

ggggaacagc caccgccgcc tccagcctcc tgcaaaagcg accaccacca ccttcgcacc      720

gcggcctcct atgaaggggg cgcgggcaac gcgaccgcag ctggggctca gcaggcttcc      780

ggagggagcc agcggccgac cccgcccggg agttgccgga ctcgcttctc agccccagct      840

tctgcgggag ggtactcggt gcagctggac gctctgcact tctcgacttt cgaggacagc      900

gccctgacag cgatgatggc gcaaaagaat ttgtctcctt ctctccccgg gagcatcttg      960

cagccagtgc aggaggaaaa cagcaaaact tcgcctcggt cccacagaag cgacggggaa     1020

ttttcccccc attcccatta cagtgactcg gatgaggcaa gttag                     1065


<210>  4
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Arg Leu Leu His Ala Glu Glu Trp Ala Glu Val Lys Glu Leu 
1               5                   10                  15      


Gly Asp His His Arg Gln Pro Gln Pro His His Leu Pro Gln Pro Pro 
            20                  25                  30          


Pro Pro Pro Gln Pro Pro Ala Thr Leu Gln Ala Arg Glu His Pro Val 
        35                  40                  45              


Tyr Pro Pro Glu Leu Ser Leu Leu Asp Ser Thr Asp Pro Arg Ala Trp 
    50                  55                  60                  


Leu Ala Pro Thr Leu Gln Gly Ile Cys Thr Ala Arg Ala Ala Gln Tyr 
65                  70                  75                  80  


Leu Leu His Ser Pro Glu Leu Gly Ala Ser Glu Ala Ala Ala Pro Arg 
                85                  90                  95      


Asp Glu Val Asp Gly Arg Gly Glu Leu Val Arg Arg Ser Ser Gly Gly 
            100                 105                 110         


Ala Ser Ser Ser Lys Ser Pro Gly Pro Val Lys Val Arg Glu Gln Leu 
        115                 120                 125             


Cys Lys Leu Lys Gly Gly Val Val Val Asp Glu Leu Gly Cys Ser Arg 
    130                 135                 140                 


Gln Arg Ala Pro Ser Ser Lys Gln Val Asn Gly Val Gln Lys Gln Arg 
145                 150                 155                 160 


Arg Leu Ala Ala Asn Ala Arg Glu Arg Arg Arg Met His Gly Leu Asn 
                165                 170                 175     


His Ala Phe Asp Gln Leu Arg Asn Val Ile Pro Ser Phe Asn Asn Asp 
            180                 185                 190         


Lys Lys Leu Ser Lys Tyr Glu Thr Leu Gln Met Ala Gln Ile Tyr Ile 
        195                 200                 205             


Asn Ala Leu Ser Glu Leu Leu Gln Thr Pro Ser Gly Gly Glu Gln Pro 
    210                 215                 220                 


Pro Pro Pro Pro Ala Ser Cys Lys Ser Asp His His His Leu Arg Thr 
225                 230                 235                 240 


Ala Ala Ser Tyr Glu Gly Gly Ala Gly Asn Ala Thr Ala Ala Gly Ala 
                245                 250                 255     


Gln Gln Ala Ser Gly Gly Ser Gln Arg Pro Thr Pro Pro Gly Ser Cys 
            260                 265                 270         


Arg Thr Arg Phe Ser Ala Pro Ala Ser Ala Gly Gly Tyr Ser Val Gln 
        275                 280                 285             


Leu Asp Ala Leu His Phe Ser Thr Phe Glu Asp Ser Ala Leu Thr Ala 
    290                 295                 300                 


Met Met Ala Gln Lys Asn Leu Ser Pro Ser Leu Pro Gly Ser Ile Leu 
305                 310                 315                 320 


Gln Pro Val Gln Glu Glu Asn Ser Lys Thr Ser Pro Arg Ser His Arg 
                325                 330                 335     


Ser Asp Gly Glu Phe Ser Pro His Ser His Tyr Ser Asp Ser Asp Glu 
            340                 345                 350         


Ala Ser 
        


<210>  5
<211>  1534
<212>  DNA
<213>  Homo sapiens

<400>  5
ctgcactctc cgacagctac tgcgctaaaa gcgctccttc cctgagcttc gggaaagagt       60

tcatcttcct gcaaaggagt ctcaggcttt cccagaggac ttgaaaggcc ttcctcgaac      120

cagccacacc aaactctgct gcagaaggtt tccttctctt tttcaacttc atgttgagaa      180

aatgactttc tcttgagcat ctcattttcc cctaaatttg ggcaagtgaa gagatatcag      240

cctggtcatc cagtagaaca gaaggccgag tcccgcactc ccccactgta aactatttga      300

ttgcacgtga gttgctttgt ttatgactta tttgctcaga agaggcacgt tgggaagcgg      360

ctcgagagac cagcccacgc gcaggtcctg agcgggcggg cgtgcgaggt cggcgcctcg      420

ctgcttgggg ccggggatga agtcctgcaa gcccagcggc ccgccggcgg gagcgcgcgt      480

tgcacccccg tgcgcgggcg gcaccgagtg cgcgggcacg tgcgccgggg ccgggcggct      540

ggagagcgcg gcgcgcaggc gcctggcggc caacgcgcgc gagcgccgcc gcatgcaggg      600

gctcaacact gccttcgacc gcttacgcag ggtggttccc cagtggggcc aggataaaaa      660

gctgtccaag tacgagaccc tgcagatggc cctgagctac atcatggctc tgacccggat      720

cctggccgag gccgagcgat tcggctcgga gcgggactgg gtgggtctcc actgtgagca      780

cttcggccgc gaccactacc tcccgttccc gggcgcgaag ctgccgggcg agagcgagct      840

gtacagccag agactcttcg gcttccagcc cgagcccttc cagatggcca cctagggcgc      900

gcgcctccgc gggggtgggt gtccggcagc cgctccgagc ctcggccctg ccccaagtag      960

cccagaagcc tccggcggcc caggattcta aggatgcaat cctcgaggaa aattagtcga     1020

ttctcagatt acctttattc gcatcatcag acctatggac gcaatcattt aattgccttt     1080

cttttcccct cctcctttgt attttgtaga tttcattaat ggatcttgtg aatgggttga     1140

ttgctgtgaa aataatgccc cctttcccct tttctgggct actttgaggg aaaacaatct     1200

taagaaaaat aggattaagc tattctgttc cagtcctcag agaaataatc actttcttaa     1260

actttgtgag tttgtcctgt tcgggtgaag ttacagtatc cattacttgt gtttgctcac     1320

aacagagcta ccttcctgtt gtgtaaatgc gtttttgctt tagtgcattg tgtgtgcaag     1380

catgaagtag aaacactttt tttttctggg tacagtacat gggtatcggt gctctgtatt     1440

tttttaaact gtgtacacat tattaaaata tacattttat aaaatataaa taaaaacgtg     1500

gatttgtttt tcatgccaaa aaaaaaaaaa aaaa                                 1534


<210>  6
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Ser Cys Lys Pro Ser Gly Pro Pro Ala Gly Ala Arg Val Ala 
1               5                   10                  15      


Pro Pro Cys Ala Gly Gly Thr Glu Cys Ala Gly Thr Cys Ala Gly Ala 
            20                  25                  30          


Gly Arg Leu Glu Ser Ala Ala Arg Arg Arg Leu Ala Ala Asn Ala Arg 
        35                  40                  45              


Glu Arg Arg Arg Met Gln Gly Leu Asn Thr Ala Phe Asp Arg Leu Arg 
    50                  55                  60                  


Arg Val Val Pro Gln Trp Gly Gln Asp Lys Lys Leu Ser Lys Tyr Glu 
65                  70                  75                  80  


Thr Leu Gln Met Ala Leu Ser Tyr Ile Met Ala Leu Thr Arg Ile Leu 
                85                  90                  95      


Ala Glu Ala Glu Arg Phe Gly Ser Glu Arg Asp Trp Val Gly Leu His 
            100                 105                 110         


Cys Glu His Phe Gly Arg Asp His Tyr Leu Pro Phe Pro Gly Ala Lys 
        115                 120                 125             


Leu Pro Gly Glu Ser Glu Leu Tyr Ser Gln Arg Leu Phe Gly Phe Gln 
    130                 135                 140                 


Pro Glu Pro Phe Gln Met Ala Thr 
145                 150         


<210>  7
<211>  2347
<212>  DNA
<213>  Homo sapiens

<400>  7
tcagtactca gacccaagtt gtgacttcct gtcaggacca agaggcagcc tgctgtggcg       60

caaaagttgg acctgggttc aagttcttct cttccacttg caggctgtga gatttaaccc      120

cagtcttggt tgttccctgt aaagtaggat ggaagtgtta tgaaatgtaa tggacacata      180

agcaatgctt ggttaccaga acaggtccca ttcatggccc acatgacaac ctgcttcccc      240

agtgggtatt tttggagaca gctcttctgt ttccaggttt tctctcctgc ctaaatgtcc      300

tgcctaagtg ccttcaagaa cccttcacca tcctgctcct gcatgtgacc aggttccatg      360

gtcagttcaa tcacctagtc acagttggta agtgacagag ttgggacttg aacctatgcc      420

tgcctgacac caagtctttt tttgacacct agagccaaga catctgaaga caaactccct      480

aggagagctg gcgtcataga aaccttaaag gttagggaga cctgggtttg aatcaggctt      540

tgtcagttat gacttgtgtg accctagcaa gttatttaac ctttctgggt ctcagtttcc      600

tcatctgcaa actgaggata ataacagtac ctaccaaaaa gaactgtcgt gaaaaccata      660

taatttctgc aatgctcctg gcacagtgtc ctgttctaaa gcatagttcc ccttctcttt      720

cttagctcca tattgattat taccctaact tgcacaaaga gacttggagg acccccatag      780

agtatcggag ggtcccccat ttcctgctct ttccactcca cacccccagc aagcacaggg      840

aagttctggg ggccataatc cacccacagg aaccaaatct aagccacctt tctggctggt      900

agacatccag gtatgtgggc acagaggtag acaggctgaa atgctgctgt gctatcagtt      960

gggttttgct ggaacaggaa tggaaatgga gaggctgaca gaactgccct ggggagccca     1020

ggcaagaggg acagtggctg gacaccccca gccagttgtg cagaccatca gaacaagatc     1080

ctagatttta ggaatacagg gttcaagtcc gtgcggcaac tcttttctaa atatgcccaa     1140

gccattaact ttgagtttta aaaatactga tttacaagct gtacacaatg aaaaaatgcc     1200

tatccctcac accatgctga tgctgttccc tgccatctca gattaccaat taaatacaga     1260

atgcccagtt aaatgtgaac tttttttttt tttttttttt tgagatggag ttttgttctt     1320

gtcgcccagg ctagagtgca atggtgcgat ctcagctcac tgcaacctct gcctcccagg     1380

ttcaagcaat tctcctgcct tagcctcctg agtagctgga actacaggtg cccaccagca     1440

cgcctggcta atttttggta tttttagtgg agatggggtt tcaccatgtt ggccaggctg     1500

gtctcgaact cctgacctca ggtgatctgc ctgcctcggc ctcccaaagt gctgggatta     1560

caggcgtgag cctaaatgtg aactttttta atactaaaaa agtatttgct gttcatctga     1620

aattcacatt taactgggtg tcctgtattt ttatttgcta aatctgccat caaattggtc     1680

tggctcaacc tggagaatgg ccaggtggtt tcagttttac aggcatcttg ggacgtggtc     1740

tccctgctcc cctgagtcct caccccagtc ctgggctccc tggcccaggc aagccccagg     1800

tattgactta cctgccaggt cggcagctcc tccttggggc tacctggtac ctgaatgtcc     1860

tggagctcta gaggttccct ccgctggagg cgtggtccgg tcagcaggtt gggattagtg     1920

tgtcataagg aacttctcac cgcccacagt ttccgttaaa tcgggctcac aggaggccct     1980

cagtggggca aaggaagacc cagagagaaa ggggagaggg gagaggcctg ggcctggctg     2040

gaggcgcatc aaagccctcc tttgtgtgct cctgctctgg agttcctgct cggccatgtg     2100

gaagcccggc tgtggggctg ggatctgggc cagtcccatt ccctcttttc tctgccctct     2160

ttctcctcaa gatcccgggg tggggttgct gagagagcac cccccccccc ccaccaccac     2220

caccagggta ataagaggtg aagggaaatc gtaaatatga ctacatctac agtggcagct     2280

ctggcaaatc caggcctatt gcccacccct cccccagcca gcaggacctg gcatggtagt     2340

tttcacc                                                               2347


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  SITE
<222>  (4)..(4)
<223>  IsoAsp

<220>
<221>  MISC_FEATURE
<222>  (4)..(7)
<223>  cyclic peptide

<220>
<221>  SITE
<222>  (7)..(7)
<223>  Diaminopropionic acid

<220>
<221>  SITE
<222>  (15)..(15)
<223>  Hx

<400>  8

Arg Arg Arg Asp Val Ala Xaa Arg Glu Ile Arg Arg Tyr Gln Xaa Ala 
1               5                   10                  15      


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Hx

<400>  9

Arg Arg Arg Thr Val Ala Leu Arg Glu Ile Arg Arg Tyr Gln Xaa Ala 
1               5                   10                  15      


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  IsoAsp

<220>
<221>  MISC_FEATURE
<222>  (4)..(7)
<223>  Cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Diaminopropionic acid

<400>  10

Arg Arg Arg Asp Val Ala Xaa Arg Glu Ile Arg Arg Tyr Gln Lys Ala 
1               5                   10                  15      


<210>  11
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Val Ala His Asn Gln Val Ala Ala Asp Asn Ala Val Ser Thr Ala 
1               5                   10                  15      


Ala Glu Pro Arg Arg Arg Pro Glu Pro Ser Ser Ser Ser Ser Ser Ser 
            20                  25                  30          


Pro Ala Ala Pro Ala Arg Pro Arg Pro Cys Pro Ala Val Pro Ala Pro 
        35                  40                  45              


Ala Pro Gly Asp Thr His Phe Arg Thr Phe Arg Ser His Ala Asp Tyr 
    50                  55                  60                  


Arg Arg Ile Thr Arg Ala Ser Ala Leu Leu Asp Ala Cys Gly Phe Tyr 
65                  70                  75                  80  


Trp Gly Pro Leu Ser Val His Gly Ala His Glu Arg Leu Arg Ala Glu 
                85                  90                  95      


Pro Val Gly Thr Phe Leu Val Arg Asp Ser Arg Gln Arg Asn Cys Phe 
            100                 105                 110         


Phe Ala Leu Ser Val Lys Met Ala Ser Gly Pro Thr Ser Ile Arg Val 
        115                 120                 125             


His Phe Gln Ala Gly Arg Phe His Leu Asp Gly Ser Arg Glu Ser Phe 
    130                 135                 140                 


Asp Cys Leu Phe Glu Leu Leu Glu His Tyr Val Ala Ala Pro Arg Arg 
145                 150                 155                 160 


Met Leu Gly Ala Pro Leu Arg Gln Arg Arg Val Arg Pro Leu Gln Glu 
                165                 170                 175     


Leu Cys Arg Gln Arg Ile Val Ala Thr Val Gly Arg Glu Asn Leu Ala 
            180                 185                 190         


Arg Ile Pro Leu Asn Pro Val Leu Arg Asp Tyr Leu Ser Ser Phe Pro 
        195                 200                 205             


Phe Gln Ile 
    210     


<210>  12
<211>  1216
<212>  DNA
<213>  Homo sapiens

<400>  12
ggcagctgca cggctcctgg ccccggagca tgcgcgagag ccgccccgga gcgccccgga       60

gccccccgcc gtcccgcccg cggcgtcccg cgccccgccg ccagcgcacc cccggacgct      120

atggcccacc cctccggctg gccccttctg taggatggta gcacacaacc aggtggcagc      180

cgacaatgca gtctccacag cagcagagcc ccgacggcgg ccagaacctt cctcctcttc      240

ctcctcctcg cccgcggccc ccgcgcgccc gcggccgtgc cccgcggtcc cggccccggc      300

ccccggcgac acgcacttcc gcacattccg ttcgcacgcc gattaccggc gcatcacgcg      360

cgccagcgcg ctcctggacg cctgcggatt ctactggggg cccctgagcg tgcacggggc      420

gcacgagcgg ctgcgcgccg agcccgtggg caccttcctg gtgcgcgaca gccgccagcg      480

gaactgcttt ttcgccctta gcgtgaagat ggcctcggga cccacgagca tccgcgtgca      540

ctttcaggcc ggccgctttc acctggatgg cagccgcgag agcttcgact gcctcttcga      600

gctgctggag cactacgtgg cggcgccgcg ccgcatgctg ggggccccgc tgcgccagcg      660

ccgcgtgcgg ccgctgcagg agctgtgccg ccagcgcatc gtggccaccg tgggccgcga      720

gaacctggct cgcatccccc tcaaccccgt cctccgcgac tacctgagct ccttcccctt      780

ccagatttga ccggcagcgc ccgccgtgca cgcagcatta actgggatgc cgtgttattt      840

tgttattact tgcctggaac catgtgggta ccctccccgg cctgggttgg agggagcgga      900

tgggtgtagg ggcgaggcgc ctcccgccct cggctggaga cgaggccgca gaccccttct      960

cacctcttga gggggtcctc cccctcctgg tgctccctct gggtccccct ggttgttgta     1020

gcagcttaac tgtatctgga gccaggacct gaactcgcac ctcctacctc ttcatgttta     1080

catataccca gtatctttgc acaaaccagg ggttggggga gggtctctgg ctttattttt     1140

ctgctgtgca gaatcctatt ttatattttt taaagtcagt ttaggtaata aactttatta     1200

tgaaagtttt tttttt                                                     1216


<210>  13
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Thr Leu Arg Cys Leu Glu Pro Ser Gly Asn Gly Gly Glu Gly Thr 
1               5                   10                  15      


Arg Ser Gln Trp Gly Thr Ala Gly Ser Ala Glu Glu Pro Ser Pro Gln 
            20                  25                  30          


Ala Ala Arg Leu Ala Lys Ala Leu Arg Glu Leu Gly Gln Thr Gly Trp 
        35                  40                  45              


Tyr Trp Gly Ser Met Thr Val Asn Glu Ala Lys Glu Lys Leu Lys Glu 
    50                  55                  60                  


Ala Pro Glu Gly Thr Phe Leu Ile Arg Asp Ser Ser His Ser Asp Tyr 
65                  70                  75                  80  


Leu Leu Thr Ile Ser Val Lys Thr Ser Ala Gly Pro Thr Asn Leu Arg 
                85                  90                  95      


Ile Glu Tyr Gln Asp Gly Lys Phe Arg Leu Asp Ser Ile Ile Cys Val 
            100                 105                 110         


Lys Ser Lys Leu Lys Gln Phe Asp Ser Val Val His Leu Ile Asp Tyr 
        115                 120                 125             


Tyr Val Gln Met Cys Lys Asp Lys Arg Thr Gly Pro Glu Ala Pro Arg 
    130                 135                 140                 


Asn Gly Thr Val His Leu Tyr Leu Thr Lys Pro Leu Tyr Thr Ser Ala 
145                 150                 155                 160 


Pro Ser Leu Gln His Leu Cys Arg Leu Thr Ile Asn Lys Cys Thr Gly 
                165                 170                 175     


Ala Ile Trp Gly Leu Pro Leu Pro Thr Arg Leu Lys Asp Tyr Leu Glu 
            180                 185                 190         


Glu Tyr Lys Phe Gln Val 
        195             


<210>  14
<211>  2759
<212>  DNA
<213>  Homo sapiens

<400>  14
agccgcggcc tcaactaaaa gtggccattg acctttcaag ctttcgagca gtgatgcaat       60

agaatagtat ttcaaagaaa aatgcttatc gaaattttgg atccggtttt cccgtgattg      120

ttaagggttt cttttaaaaa gtaggtcaca tttcaagtag gtcatatttc gggggcgggt      180

gcgcagacaa ggagatgagt ttccactaag gccagggggc ctccaacggg gttggaggtg      240

agaatcccag gtagggtaga ggtgccgaga tccttccgaa tcccagccct ggggcgtcag      300

ccctgcaggg aatggcagag acactctccg gactgaggga accgaggcca gtcaccaagc      360

cccttccggg cgcgcaggcg atcagtgggt gaccgcggct gcgagggact ttgtcatccg      420

tcctccagga tctggggaga aagagcccca tcccttctct ctctgccacc atttcggaca      480

ccccgcaggg actcgttttg ggattcgcac tgacttcaag gaaggacgcg aacccttctc      540

tgaccccagc tcgggcggcc acctgtcttt gccgcggtga cccttctctc atgaccctgc      600

ggtgccttga gccctccggg aatggcgggg aagggacgcg gagccagtgg gggaccgcgg      660

ggtcggcgga ggagccatcc ccgcaggcgg cgcgtctggc gaaggccctg cgggagctcg      720

gtcagacagg atggtactgg ggaagtatga ctgttaatga agccaaagag aaattaaaag      780

aggcaccaga aggaactttc ttgattagag atagctcgca ttcagactac ctactaacaa      840

tatctgttaa aacatcagct ggaccaacta atcttcgaat cgaataccaa gacggaaaat      900

tcagattgga ctctatcata tgtgtcaaat ccaagcttaa acaatttgac agtgtggttc      960

atctgatcga ctactatgtt cagatgtgca aggataagcg gacaggtcca gaagcccccc     1020

ggaacggcac tgttcacctt tatctgacca aaccgctcta cacgtcagca ccatctctgc     1080

agcatctctg taggctcacc attaacaaat gtaccggtgc catctgggga ctgcctttac     1140

caacaagact aaaagattac ttggaagaat ataaattcca ggtataaatg tttctctttt     1200

tttaaacatg tctcacatag agtatctccg aatgcagcta tgtaaaagag aaccaaaact     1260

tgagtgctct ggataactat atggaatgct ttctaagaac agctgaagct aatctaattt     1320

aaatttaaca gcttgaagag gtagctaggt gtttaaagtt cctccagata cttttacctg     1380

agtgatgctt cccttcctaa ggctgaccaa gacctgttga tccttttaga ttaaaaataa     1440

aatgtcgcat gtaaaggctg aagtcgcgtt ttatcagaat gccttgcctt cttaggttct     1500

tttccattat gtcaaaggtc caggctccag taggagagaa agaactcctc ataggaatac     1560

tgaagaagtg ggaaggaacc aagctgacac aggcctcact gcaatttgat atgcctgctg     1620

atcagagtct cttgggcatt ttatattttg cattctgatg tacctaggag ttttgttaaa     1680

cagatgatgt atgtgagtat ttatcccatt ttatgcaatt aaccaaatca accaaaaaaa     1740

gtgaccatga agtcctgtat ttgtcttttt actacatgta ggaactctca tgtgaatgag     1800

tactgtagta atccattcta tgggagcctt atttcagaaa tatttcaaac tggtgcaaat     1860

ggaaaagact ttctcttttc ctttaaagct aaagacaaga atatcatgct atacaggtgc     1920

aactcaatcc ccgttaataa aaaccaatgt aggtataggc attctaccct ttgaaatagc     1980

tgtgtcccaa cctgttgcca ttgatttttt ggaaatggct ttagaaatat ccaagttgtc     2040

cttgaattgt ctaaccatgg acataaacag ttgtctccct tctactgtgt agaatacttt     2100

gacttaattt tcttccagat acagggggat acctgcctgt ttttcaaagt gtttatttac     2160

tgctgttact atttgattag aatgtattaa ataaaaaaaa cctgatttct acaagttgca     2220

cttattgagt tctagagaac gtacactttc atggtaatag aggattgcca taaaaactta     2280

cgtcaagtga aataagccaa ttattcaaca aaaggtagaa cattacttgc cattctgtaa     2340

agttatgggc tgtacctgcc ccctttgcaa tttggaaagc atggtttaga aactacaggc     2400

attgtcaagt ggccgggtct tttataattt gaataggcat aacactgatg tcctctgtgt     2460

ttccaaaaac atggtttaga aactacaaac attatgacat ggccagtctt ttacaagttg     2520

agtaggcata atactaaaga aaaatacaaa gttttgtggc cacttatttt ttgctatgtt     2580

agtctgcata actgttataa atgtaccatc ttttctagag tccagacatt atttatttta     2640

tggctttaaa attttcctgc atagctacaa tcctgtggtg tgtcaccata aaggtggacc     2700

ctgtgtgaat gagaaaattc agttataaat tgtaataaaa cctgcttact ggaaaaaaa      2759


<210>  15
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Val Thr His Ser Lys Phe Pro Ala Ala Gly Met Ser Arg Pro Leu 
1               5                   10                  15      


Asp Thr Ser Leu Arg Leu Lys Thr Phe Ser Ser Lys Ser Glu Tyr Gln 
            20                  25                  30          


Leu Val Val Asn Ala Val Arg Lys Leu Gln Glu Ser Gly Phe Tyr Trp 
        35                  40                  45              


Ser Ala Val Thr Gly Gly Glu Ala Asn Leu Leu Leu Ser Ala Glu Pro 
    50                  55                  60                  


Ala Gly Thr Phe Leu Ile Arg Asp Ser Ser Asp Gln Arg His Phe Phe 
65                  70                  75                  80  


Thr Leu Ser Val Lys Thr Gln Ser Gly Thr Lys Asn Leu Arg Ile Gln 
                85                  90                  95      


Cys Glu Gly Gly Ser Phe Ser Leu Gln Ser Asp Pro Arg Ser Thr Gln 
            100                 105                 110         


Pro Val Pro Arg Phe Asp Cys Val Leu Lys Leu Val His His Tyr Met 
        115                 120                 125             


Pro Pro Pro Gly Ala Pro Ser Phe Pro Ser Pro Pro Thr Glu Pro Ser 
    130                 135                 140                 


Ser Glu Val Pro Glu Gln Pro Ser Ala Gln Pro Leu Pro Gly Ser Pro 
145                 150                 155                 160 


Pro Arg Arg Ala Tyr Tyr Ile Tyr Ser Gly Gly Glu Lys Ile Pro Leu 
                165                 170                 175     


Val Leu Ser Arg Pro Leu Ser Ser Asn Val Ala Thr Leu Gln His Leu 
            180                 185                 190         


Cys Arg Lys Thr Val Asn Gly His Leu Asp Ser Tyr Glu Lys Val Thr 
        195                 200                 205             


Gln Leu Pro Gly Pro Ile Arg Glu Phe Leu Asp Gln Tyr Asp Ala Pro 
    210                 215                 220                 


Leu 
225 


<210>  16
<211>  2737
<212>  DNA
<213>  Homo sapiens

<400>  16
gcggctccga cttggactcc ctgctccgct gctgccgctt cggccccgca cgcagccagc       60

cgccagccgc ccgcccggcc cagctcccgc cgcggcccct tgccgcggtc cctctcctgg      120

tcccctcccg gttggtccgg gggtgcgcag ggggcagggc gggcgcccag gggaagctcg      180

agggacgcgc gcgcgaaggc tcctttgtgg acttcacggc cgccaacatc tgggcgcagc      240

gcgggccacc gctggccgtc tcgccgccgc gtcgccttgg ggacccgagg gggctcagcc      300

ccaaggacgg agacttcgat tcgggaccag ccccccggga tgcggtagcg gccgctgtgc      360

ggaggccgcg aagcagctgc agccgccgcc gcgcagatcc acgctggctc cgtgcgccat      420

ggtcacccac agcaagtttc ccgccgccgg gatgagccgc cccctggaca ccagcctgcg      480

cctcaagacc ttcagctcca agagcgagta ccagctggtg gtgaacgcag tgcgcaagct      540

gcaggagagc ggcttctact ggagcgcagt gaccggcggc gaggcgaacc tgctgctcag      600

tgccgagccc gccggcacct ttctgatccg cgacagctcg gaccagcgcc acttcttcac      660

gctcagcgtc aagacccagt ctgggaccaa gaacctgcgc atccagtgtg aggggggcag      720

cttctctctg cagagcgatc cccggagcac gcagcccgtg ccccgcttcg actgcgtgct      780

caagctggtg caccactaca tgccgccccc tggagccccc tccttcccct cgccacctac      840

tgaaccctcc tccgaggtgc ccgagcagcc gtctgcccag ccactccctg ggagtccccc      900

cagaagagcc tattacatct actccggggg cgagaagatc cccctggtgt tgagccggcc      960

cctctcctcc aacgtggcca ctcttcagca tctctgtcgg aagaccgtca acggccacct     1020

ggactcctat gagaaagtca cccagctgcc ggggcccatt cgggagttcc tggaccagta     1080

cgatgccccg ctttaagggg taaagggcgc aaagggcatg ggtcgggaga ggggacgcag     1140

gcccctctcc tccgtggcac atggcacaag cacaagaagc caaccaggag agagtcctgt     1200

agctctgggg ggaaagaggg cggacaggcc cctccctctg ccctctccct gcagaatgtg     1260

gcaggcggac ctggaatgtg ttggagggaa gggggagtac cacctgagtc tccagcttct     1320

ccggaggagc cagctgtcct ggtgggacga tagcaaccac aagtggattc tccttcaatt     1380

cctcagcttc ccctctgcct ccaaacaggg gacacttcgg gaatgctgaa ctaatgagaa     1440

ctgccaggga atcttcaaac tttccaacgg aacttgtttg ctctttgatt tggtttaaac     1500

ctgagctggt tgtggagcct gggaaaggtg gaagagagag aggtcctgag ggccccaggg     1560

ctgcgggctg gcgaaggaaa tggtcacacc ccccgcccac cccaggcgag gatcctggtg     1620

acatgctcct ctccctggct ccggggagaa gggcttgggg tgacctgaag ggaaccatcc     1680

tggtacccca catcctctcc tccgggacag tcaccgaaaa cacaggttcc aaagtctacc     1740

tggtgcctga gagcccaggg cccttcctcc gttttaaggg ggaagcaaca tttggagggg     1800

atggatgggc tggtcagctg gtctcctttt cctactcata ctataccttc ctgtacctgg     1860

gtggatggag cgggaggatg gaggagacgg gacatctttc acctcaggct cctggtagag     1920

aagacagggg attctactct gtgcctcctg actatgtctg gctaagagat tcgccttaaa     1980

tgctccctgt cccatggaga gggacccagc ataggaaagc cacatactca gcctggatgg     2040

gtggagaggc tgagggactc actggagggc accaagccag cccacagcca gggaagtggg     2100

gagggggggc ggaaacccat gcctcccagc tgagcactgg gaatgtcagc ccagtaagta     2160

ttggccagtc aggcgcctcg tggtcagagc agagccacca ggtcccactg ccccgagccc     2220

tgcacagccc tccctcctgc ctgggtgggg gaggctggag gtcattggag aggctggact     2280

gctgccaccc cgggtgctcc cgctctgcca tagcactgat cagtgacaat ttacaggaat     2340

gtagcagcga tggaattacc tggaacagtt ttttgttttt gtttttgttt ttgtttttgt     2400

gggggggggc aactaaacaa acacaaagta ttctgtgtca ggtattgggc tggacagggc     2460

agttgtgtgt tggggtggtt tttttctcta tttttttgtt tgtttcttgt tttttaataa     2520

tgtttacaat ctgcctcaat cactctgtct tttataaaga ttccacctcc agtcctctct     2580

cctcccccct actcaggccc ttgaggctat taggagatgc ttgaagaact caacaaaatc     2640

ccaatccaag tcaaactttg cacatattta tatttatatt cagaaaagaa acatttcagt     2700

aatttataat aaagagcact attttttaat gaaaaac                              2737


<210>  17
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Glu Asn Asn Glu Asn Ile Ser Lys Asn Val Asp Val Arg Pro 
1               5                   10                  15      


Lys Thr Ser Arg Ser Arg Ser Ala Asp Arg Lys Asp Gly Tyr Val Trp 
            20                  25                  30          


Ser Gly Lys Lys Leu Ser Trp Ser Lys Lys Ser Glu Ser Tyr Ser Asp 
        35                  40                  45              


Ala Glu Thr Val Asn Gly Ile Glu Lys Thr Glu Val Ser Leu Arg Asn 
    50                  55                  60                  


Gln Glu Arg Lys His Ser Cys Ser Ser Ile Glu Leu Asp Leu Asp His 
65                  70                  75                  80  


Ser Cys Gly His Arg Phe Leu Gly Arg Ser Leu Lys Gln Lys Leu Gln 
                85                  90                  95      


Asp Ala Val Gly Gln Cys Phe Pro Ile Lys Asn Cys Ser Ser Arg His 
            100                 105                 110         


Ser Ser Gly Leu Pro Ser Lys Arg Lys Ile His Ile Ser Glu Leu Met 
        115                 120                 125             


Leu Asp Lys Cys Pro Phe Pro Pro Arg Ser Asp Leu Ala Phe Arg Trp 
    130                 135                 140                 


His Phe Ile Lys Arg His Thr Ala Pro Ile Asn Ser Lys Ser Asp Glu 
145                 150                 155                 160 


Trp Val Ser Thr Asp Leu Ser Gln Thr Glu Leu Arg Asp Gly Gln Leu 
                165                 170                 175     


Lys Arg Arg Asn Met Glu Glu Asn Ile Asn Cys Phe Ser His Thr Asn 
            180                 185                 190         


Val Gln Pro Cys Val Ile Thr Thr Asp Asn Ala Leu Cys Arg Glu Gly 
        195                 200                 205             


Pro Met Thr Gly Ser Val Met Asn Leu Val Ser Asn Asn Ser Ile Glu 
    210                 215                 220                 


Asp Ser Asp Met Asp Ser Asp Asp Glu Ile Leu Thr Leu Cys Thr Ser 
225                 230                 235                 240 


Ser Arg Lys Arg Asn Lys Pro Lys Trp Asp Leu Asp Asp Glu Ile Leu 
                245                 250                 255     


Gln Leu Glu Thr Pro Pro Lys Tyr His Thr Gln Ile Asp Tyr Val His 
            260                 265                 270         


Cys Leu Val Pro Asp Leu Leu Gln Ile Asn Asn Asn Pro Cys Tyr Trp 
        275                 280                 285             


Gly Val Met Asp Lys Tyr Ala Ala Glu Ala Leu Leu Glu Gly Lys Pro 
    290                 295                 300                 


Glu Gly Thr Phe Leu Leu Arg Asp Ser Ala Gln Glu Asp Tyr Leu Phe 
305                 310                 315                 320 


Ser Val Ser Phe Arg Arg Tyr Ser Arg Ser Leu His Ala Arg Ile Glu 
                325                 330                 335     


Gln Trp Asn His Asn Phe Ser Phe Asp Ala His Asp Pro Cys Val Phe 
            340                 345                 350         


His Ser Pro Asp Ile Thr Gly Leu Leu Glu His Tyr Lys Asp Pro Ser 
        355                 360                 365             


Ala Cys Met Phe Phe Glu Pro Leu Leu Ser Thr Pro Leu Ile Arg Thr 
    370                 375                 380                 


Phe Pro Phe Ser Leu Gln His Ile Cys Arg Thr Val Ile Cys Asn Cys 
385                 390                 395                 400 


Thr Thr Tyr Asp Gly Ile Asp Ala Leu Pro Ile Pro Ser Ser Met Lys 
                405                 410                 415     


Leu Tyr Leu Lys Glu Tyr His Tyr Lys Ser Lys Val Arg Val Leu Arg 
            420                 425                 430         


Ile Asp Ala Pro Glu Gln Gln Cys 
        435                 440 


<210>  18
<211>  6903
<212>  DNA
<213>  Homo sapiens

<400>  18
acggaagtgg tggcggcgcc cagggaaccg gcggaggcga tgaccgtgac ggctgggttg       60

ggaccggaac gccgaagcgg ggttgggggt ggcagaaaag catctgcttt gtaagaccta      120

cacgaggtgc aggagtggtt gggcctcccc tctccactta agcaagcgcc cagactgatg      180

gcgatggtga tggcagcagt tactcgcaca accccagtta agctgcgctc cgggaggagt      240

tcatctgttg tctgctctcc agtgacttcc gtttgtggag cctaagtgtt tctacagaat      300

ccaactcaaa tatcaaggac tatgatcaga atgctttcaa ggagtttttg ggcacatgat      360

ggcagataca tccagaaagt gcccagaaga aacttcctgc tggaaaaaat gaaaaagcag      420

tatttataac attagaatct ggataatttg ttaacatggc agaaaataat gaaaatatta      480

gtaaaaatgt agatgtaagg cccaaaacta gtcggagcag aagtgccgac agaaaagacg      540

gttatgtgtg gagtggaaag aagttatctt ggtcaaaaaa gagtgagagt tattcagatg      600

ctgagacagt gaatggtata gagaaaaccg aagtgtcttt aaggaaccaa gaaaggaagc      660

acagctgttc atccattgag ttggacttag atcattcctg tgggcatcga tttttaggcc      720

gatctcttaa acagaaactg caagatgccg tggggcagtg ttttccaata aagaattgta      780

gtagtcggca ctcttcaggg cttccgtcta aaaggaaaat tcatatcagt gaactcatgt      840

tagataagtg tcctttccca cctcgatcag atttagcctt taggtggcat tttattaaac      900

gacacactgc tcctataaat tccaaatcag atgaatgggt aagcacagac ttgtctcaga      960

ctgaattgag ggatggtcag ctaaaacgaa gaaatatgga agaaaatata aactgtttct     1020

cacataccaa tgttcagccc tgtgtcataa ccaccgacaa tgctttgtgt agagaaggtc     1080

ctatgactgg ctctgtgatg aacctggttt caaataacag tatagaagat agtgatatgg     1140

attccgatga tgaaattcta acactttgca caagttccag aaaaagaaac aaacccaaat     1200

gggatttgga tgatgaaatc ctgcagttgg aaacacctcc taaataccac acgcagattg     1260

attatgtcca ctgtcttgta ccagacctcc ttcagatcaa taacaaccca tgttactggg     1320

gagtgatgga taaatacgca gccgaagcac tactggaagg aaaaccagag ggtacctttt     1380

tacttcgaga ctcagcacag gaagactatt tattctctgt tagttttaga cgctatagtc     1440

gttctcttca tgctagaatt gaacagtgga atcacaactt tagctttgat gcacatgacc     1500

cctgtgtctt ccattctcct gacattactg ggctcctaga acattataag gacccaagcg     1560

cctgtatgtt ctttgaacca cttctatcca ctcccttaat tcggactttc cctttttccc     1620

tgcagcatat atgcagaaca gttatttgta actgtacaac ttatgatggc atcgatgccc     1680

ttccaattcc ttcttctatg aaattatatc tgaaggaata tcattataaa tcaaaagtta     1740

gagtactcag gattgatgca ccagaacagc aatgctagta acaggatggg aacatgggaa     1800

tgataatata tattttttct tttaatattt tatttttctt tttatgccac tttggatttt     1860

tctacaaagg cagtggtgtc caaaataaaa tctctgccct aaattttact aataaatcca     1920

tttttctagt gatacacaaa ttgtttaagg ttatacactc gagcttaaat agatattttt     1980

aaccaggtgt ttggtttttg tttttaccgt gtaggttgta tacttacatt ttttctttcc     2040

ttaatttata catgatcctt tttccttaat ttatacatga tccaggcaca tttgaaattt     2100

ggtaggcatt gcaaacacat ttgaatattg tgtatttcat actattcttt aaaagtaatc     2160

ttatgtcctt tcctacatgt aaaatatttt gttaatctat gccattagta gtattatata     2220

taaaatatag ttccccgtcc cccttttcat tgagtttgat attcttcagt aaagctgaat     2280

gttgtaattc accattcata ctaatgttat tgacttttgt aacttactaa tagggatgtt     2340

aaaagtaaca aaaccaagtc aaacttggtg tatttttatt ttaaatatta actctaaagc     2400

aggattacta aatttgatta atctggtcaa tgagaatcaa atggaaacat atcattctgg     2460

aggtgcactt actcttctac aatgtggccg gatcatttgt cattcctgaa taggtctttc     2520

tctcaacctg caagagctaa accatcttca aaacataaat cttgttcctt tctcattgga     2580

agctttgaaa ataatgataa cactattagt agctagtagt tactaaagtg ctaaagtaat     2640

tgtggggttt ttctgtatta gcttatgaac tgttgcttct acttagccct tttatagaaa     2700

ctctgagctg ttactttggg gaaattccac aatgtattag cagccacaaa tttccactgg     2760

taaccaaaga gtacctaagt agtttttcat tattttaagt tgaatttgaa taaagattcc     2820

agaaataaac atggagctca gtattcagga agcttaatac tgtttttgat ctacaagatc     2880

caaataatta tccctatctt cagaattaac ttagtctgta atgtggcttc aaaaaaagaa     2940

agccttttga cagctacatg acttacacca tacagaacag tactggacaa aaggggtgat     3000

attttaaatt tactatccca gaaacagggc aacgttttta gaaacatctt tagcccaaag     3060

taactagtaa aaataaatgg agtggtatcc tatcttcttt ttttaaggaa tcaatgaata     3120

ataaatgtag atagacaatt ttcttctggt gagctgtcta accctttgta cacattgaca     3180

tttttaatat cgtaactgat ttcttgatgc tagtttagct atattaggaa actgcttcta     3240

cctagattga aagaaatttg actcataaac ttccaagtta gaacaaatat ttcttcatta     3300

ttgttgcttt tatgtgagta gcatttccct atcttgcagt tctgttaaca tgaaaatggc     3360

atttttccat aatagcttta aaataatttt ttagtaatta ttacaaaatt aaggaaaatc     3420

tctattaccg ttatctttta gcattttttt tttcctcagt gatctcaaga ttgtcttagt     3480

ctcaatgaga tgtagctaca aaaatggcac ctcttagcag tgatgaggct caggatatcg     3540

gatatcataa caccaatgtc aggataaata tctcttctaa agacgatatt taccttttac     3600

aaggttagaa aagtctcata ctacctcatc tttattgtgg cgcttttgta gatcactgag     3660

aagcttatct tattaaccaa tataccactt cctaaatatc catctttggt gaaagaaaat     3720

agtgtggtaa gagtacccat gattatagtt ttttatcaga atttgataag attttctgtt     3780

tctgtgaaac aattatttta aatatttttc ttttaaaaat aactttttat cagtacagaa     3840

aaacctaagg gatgactagc ttacaaatat tctgttaagg ggtagtttta taaagaaaaa     3900

tgatatatag ttatgttgtc ttttatagtg ttaaaattag tatttatatg aaagtcaaga     3960

tctaagtacc ttttcatata attcaaactg attgcttgtg atatgttttc tctggctttt     4020

ttattttttc aacttcaagg tattaacagc tgttaacact taaaaagtac tgccacatat     4080

gtagccttga agtagttgat ctaataaatg agagcaggga ggagattcat tgactctgaa     4140

atgattttta tttttccttt ggtatttgct acagtgaaaa gaagtttgga aagtagatac     4200

ataaagactt gagaagggaa ttgtttaagg gaaaagaaaa gagtaataat tttttttaaa     4260

acattaagga attggaattc agaaaggtta cccccttcct ctgtgtcttt gtaaggatac     4320

atttggaaga acatacagta ttcagaaact aacctatata aaatgtaaac aatatattga     4380

ttgcactata taaatgagta aattttgaga ggaacaatgt gggaatgtat aaatttgtct     4440

aaaattttat aactgttgaa caaagggaag atttgaacag tgtaaattcc agagttgaga     4500

aagcatttag catggtggaa atgtggagag cttattggtg agagaggatg gagctaagag     4560

aaataagatc aaatattaaa attaggaatt taggcattac ctcagggaaa agccttgaca     4620

gtgaaaagaa actacttaat cgctaatagc tagtctggac cagacactta actgcgcttt     4680

gggaatcatc ctgggctaat caggaaataa acttgacttt tctatttttc tctgaagctt     4740

tacaggacat actcccactc ccattttttt ctaagcctac agcatcttga ttcatagtat     4800

aattcctgaa gtatgctgaa tggacttttt aaggttcctt tagcattttt gtatagagtt     4860

atatgtgatc tttctataac catgccattc acttaaataa ttcatgaagg gaatggttta     4920

atttaaagga agacctaata ggaagaagat taaaggaagc ttttagtcag cctgtggcta     4980

gatttattga tttggtgatc aaacctgtgc tatttcctga atttcagcta atggccaact     5040

gtggtcaaag aatggctttc agttaaagtt ttgacttctt attataaata atataaagaa     5100

tgtctcagta attagaaatc ccttaataag tagaacaaat gtggcaagta ggactcctat     5160

cggtatacaa attccatttc tttttataag aaaaacacat aaaccattat catttattca     5220

tgagccaaag ccattaagaa gataaatcca gttatcagct tcctgtctct gaagtttgga     5280

tcattttata gatccacgca atagagagct tccttcctat gaaacaaaaa ccttgagatc     5340

tctttttttt tgagacagag tctcgctgtt gtcagcccag gctggagtgc aatggcgcaa     5400

tctcggttca ctgcaacctc tgccttccag gttccagcaa ttctcctacc tcagctccca     5460

agtagctgag atgacaggcg tgtgccacca cgcccagcta atttttgtat ttttagtagc     5520

gatggtgttt cactacattg gccaggctgg tctcgaactc ctgacctcag gtgaccaccc     5580

gcctcagcct cccaaagtgc tgggattaca ggcatgagcc actgtgcccg gccaagatct     5640

aactcacgct tacttttcat taaaatattt cttgtcgctt ttagctattg tcagaatcca     5700

ataaacagct tacgcattca ttttggtaaa gcaaatttca caggaaaata gacaaaatta     5760

taagagattc ctggagacaa cacaaggaaa acaatgttta aaagcaaaat agcctgtgta     5820

atgttaggta atgtaatgcc caagtgaata aaagattttt cgtcaagcaa actactgttt     5880

ctactttggg ggaaaaaagt cagttttaca tttgtaattt aaggaaagaa cagaaagcac     5940

aaaggttttt cttttcttta ttaatggcct actagaaatg agcagtgcaa gagtctacct     6000

gtactattct aatacagtaa gatattggac acaaaatgga ggtaactttt taaaatagat     6060

tggcttggaa gttgaaatgt agattaatgg atataaccca atagaaaggg attttcaaat     6120

aaaaccaaag tctatttttt tatttacttt ctaattttga acagatgact cagtcctaaa     6180

tctttgcctt tatttcctat aaaatgtagg tgatacttgt aactcgactt cctggagtta     6240

attcttcagc aagaggtgac cctgggagcg tactttaaaa taattgctgt acagccattg     6300

agtactaaca tgatgatagg ttttcaaaat atctttgtag tggatgctgc ataattacat     6360

tcacttctct tagactgtaa aagactttct tgacttgttt taacagtaga gatagcagta     6420

caatttgaat ttatggttta ggctctgcaa ttagaggaac aattgcagtt tcctcctacc     6480

cttcatatgg tctgtgtaaa actgatgttt gcttaactta ttttaaaagt tgattacgtt     6540

ttcagaaaat aaagataatc acttttgcca tggttataat caaatctaag ctttcagact     6600

tgagagccat ggtgtaaaac tcaaggaggt ttatttaaat tatgctgact ttgctagaat     6660

tggataaatt ctgtataagc caagtatgag ttcacatgta ctcgaatata cagttttcac     6720

aaagctatta ctctcatcag tcaggcttgt atgatctatt ccttaccaca aaagaagtag     6780

acaattgcca cttttatttc taatccttaa gttgaatgtt tcttcttgga tgtaagttca     6840

aataaattga tctggataaa ttttcatttc tacttaatta aaacttccta tgtaaaatcc     6900

aaa                                                                   6903


<210>  19
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asp Lys Val Gly Lys Met Trp Asn Asn Phe Lys Tyr Arg Cys Gln 
1               5                   10                  15      


Asn Leu Phe Gly His Glu Gly Gly Ser Arg Ser Glu Asn Val Asp Met 
            20                  25                  30          


Asn Ser Asn Arg Cys Leu Ser Val Lys Glu Lys Asn Ile Ser Ile Gly 
        35                  40                  45              


Asp Ser Thr Pro Gln Gln Gln Ser Ser Pro Leu Arg Glu Asn Ile Ala 
    50                  55                  60                  


Leu Gln Leu Gly Leu Ser Pro Ser Lys Asn Ser Ser Arg Arg Asn Gln 
65                  70                  75                  80  


Asn Cys Ala Thr Glu Ile Pro Gln Ile Val Glu Ile Ser Ile Glu Lys 
                85                  90                  95      


Asp Asn Asp Ser Cys Val Thr Pro Gly Thr Arg Leu Ala Arg Arg Asp 
            100                 105                 110         


Ser Tyr Ser Arg His Ala Pro Trp Gly Gly Lys Lys Lys His Ser Cys 
        115                 120                 125             


Ser Thr Lys Thr Gln Ser Ser Leu Asp Ala Asp Lys Lys Phe Gly Arg 
    130                 135                 140                 


Thr Arg Ser Gly Leu Gln Arg Arg Glu Arg Arg Tyr Gly Val Ser Ser 
145                 150                 155                 160 


Val His Asp Met Asp Ser Val Ser Ser Arg Thr Val Gly Ser Arg Ser 
                165                 170                 175     


Leu Arg Gln Arg Leu Gln Asp Thr Val Gly Leu Cys Phe Pro Met Arg 
            180                 185                 190         


Thr Tyr Ser Lys Gln Ser Lys Pro Leu Phe Ser Asn Lys Arg Lys Ile 
        195                 200                 205             


His Leu Ser Glu Leu Met Leu Glu Lys Cys Pro Phe Pro Ala Gly Ser 
    210                 215                 220                 


Asp Leu Ala Gln Lys Trp His Leu Ile Lys Gln His Thr Ala Pro Val 
225                 230                 235                 240 


Ser Pro His Ser Thr Phe Phe Asp Thr Phe Asp Pro Ser Leu Val Ser 
                245                 250                 255     


Thr Glu Asp Glu Glu Asp Arg Leu Arg Glu Arg Arg Arg Leu Ser Ile 
            260                 265                 270         


Glu Glu Gly Val Asp Pro Pro Pro Asn Ala Gln Ile His Thr Phe Glu 
        275                 280                 285             


Ala Thr Ala Gln Val Asn Pro Leu Tyr Lys Leu Gly Pro Lys Leu Ala 
    290                 295                 300                 


Pro Gly Met Thr Glu Ile Ser Gly Asp Ser Ser Ala Ile Pro Gln Ala 
305                 310                 315                 320 


Asn Cys Asp Ser Glu Glu Asp Thr Thr Thr Leu Cys Leu Gln Ser Arg 
                325                 330                 335     


Arg Gln Lys Gln Arg Gln Ile Ser Gly Asp Ser His Thr His Val Ser 
            340                 345                 350         


Arg Gln Gly Ala Trp Lys Val His Thr Gln Ile Asp Tyr Ile His Cys 
        355                 360                 365             


Leu Val Pro Asp Leu Leu Gln Ile Thr Gly Asn Pro Cys Tyr Trp Gly 
    370                 375                 380                 


Val Met Asp Arg Tyr Glu Ala Glu Ala Leu Leu Glu Gly Lys Pro Glu 
385                 390                 395                 400 


Gly Thr Phe Leu Leu Arg Asp Ser Ala Gln Glu Asp Tyr Leu Phe Ser 
                405                 410                 415     


Val Ser Phe Arg Arg Tyr Asn Arg Ser Leu His Ala Arg Ile Glu Gln 
            420                 425                 430         


Trp Asn His Asn Phe Ser Phe Asp Ala His Asp Pro Cys Val Phe His 
        435                 440                 445             


Ser Ser Thr Val Thr Gly Leu Leu Glu His Tyr Lys Asp Pro Ser Ser 
    450                 455                 460                 


Cys Met Phe Phe Glu Pro Leu Leu Thr Ile Ser Leu Asn Arg Thr Phe 
465                 470                 475                 480 


Pro Phe Ser Leu Gln Tyr Ile Cys Arg Ala Val Ile Cys Arg Cys Thr 
                485                 490                 495     


Thr Tyr Asp Gly Ile Asp Gly Leu Pro Leu Pro Ser Met Leu Gln Asp 
            500                 505                 510         


Phe Leu Lys Glu Tyr His Tyr Lys Gln Lys Val Arg Val Arg Trp Leu 
        515                 520                 525             


Glu Arg Glu Pro Val Lys Ala Lys 
    530                 535     


<210>  20
<211>  4422
<212>  DNA
<213>  Homo sapiens

<400>  20
cgcagagcgc gcacccaagc ggccggacct ccccgactcc cgggccgccc ccgtctcgcg       60

ccctgcctcc ctccttcggc cttcacctac ccgcctccgg attggccgct aggaatcccg      120

cccctctaaa gccctgcctg ctattggtca cgattttata atcaatggat aaagtgggaa      180

aaatgtggaa taacttcaaa tacaggtgtc agaatctctt cggtcatgag ggaggaagcc      240

gtagtgaaaa tgtggacatg aactccaaca gatgtttgtc tgtcaaagag aaaaacatca      300

gcataggaga ctcaactcct cagcaacaaa gcagtccctt aagagaaaat attgccttac      360

aactgggatt aagcccttcg aagaattctt caaggagaaa tcaaaattgt gccacagaaa      420

tccctcaaat tgttgaaata agcatcgaaa aggataatga ttcttgtgtt accccaggaa      480

caagacttgc acgaagagat tcctactctc gacatgctcc atggggtggg aagaaaaaac      540

attcctgttc tacaaagacc cagagttcat tggatgctga taaaaagttt ggtagaactc      600

gaagtggact tcaaaggaga gagaggcgct acggcgtaag ttctgtacac gacatggaca      660

gtgtttccag cagaactgta ggaagtcgct ctctaagaca gaggttgcag gatactgtgg      720

gcttgtgttt tcccatgaga acttacagca agcagtcaaa gcctctcttt tccaataaaa      780

gaaaaatcca tctctctgaa ttaatgcttg agaaatgccc ttttcctgct ggctcagatt      840

tagcccaaaa atggcatttg attaaacagc atacagctcc tgtgagccca cattcaacat      900

tttttgatac atttgatcca tctttggttt ctacagaaga tgaagaagat aggcttagag      960

agagaaggcg gcttagtatt gaagaagggg ttgatccccc tcccaatgca caaatacata     1020

catttgaagc tactgcacag gttaatccat tatataaact gggaccaaaa ttagctcctg     1080

gaatgactga aataagtggg gacagttctg caattccaca agctaattgt gactcggaag     1140

aggatacaac caccctgtgt ttgcagtcac ggaggcagaa gcagcgtcag atatctggag     1200

acagccatac ccatgttagc agacagggag cttggaaagt ccacacacag attgattaca     1260

tacactgcct cgtgcctgat ttgcttcaaa ttacagggaa tccctgttac tggggagtga     1320

tggaccgtta tgaagcagaa gcccttctcg aagggaaacc tgaaggcacg tttttgctca     1380

gggactctgc gcaagaggac tacctcttct ctgtgagctt ccgccgctac aacagatccc     1440

tgcatgcccg aattgagcag tggaatcaca actttagttt cgacgcccat gacccgtgtg     1500

tatttcactc ctccactgta acgggacttt tagaacatta taaagatccc agttcgtgca     1560

tgttttttga accattgctt actatatcac taaataggac tttccctttt agcctgcagt     1620

atatctgtcg cgcggtaatc tgcaggtgca ctacgtatga tggaattgat gggctccctc     1680

taccctcaat gttacaggat tttttaaaag agtatcatta taaacaaaaa gttagagttc     1740

gctggttgga acgagaacca gtcaaggcaa agtaaactct ccggtcccca aaggttgtta     1800

actaggtccg ctttcatgtg catcagacag tacacctata gcaagcacac gtagcagtgt     1860

taggcttttt catacagtat gtaagcttag tgttagtatc tgtcagatgc tacctgctgt     1920

tacttattca gataaacatg gtgcctattg gaacaatagc ggatagagct acaggtgttc     1980

agtaagacta caaaaacatt ttgcctattt cgctaacagt ttggttttta atggctgtgg     2040

tatttgagtg aggcaactct ggggcatttg ttatgaagaa ttctatttct tactgaagaa     2100

caaattatta atattggatg agtatttcaa cagtgtgact aatgtttgaa attatttttt     2160

ctaagagttt ttctataacc ttccaaaagt cgtgatgttt gtagttacta taaatcaagc     2220

tttggaagtc caaaaagaat aaaagactgc cttcctttta gaaaaaaatg caattttctg     2280

gccacaaggg catagtgcag ttcacttacg tgttgatgta gtttataatc agacgccttt     2340

tctcttctgc aaaaggtact gttaagtaaa ccagattttc taaataggca ttcttaaaat     2400

ttcagactta caaagctagt agtagaattt tattgaaagg cctaggtatt aattttttaa     2460

atgagtgctt taacttaaaa caggcgtttg gaatagctgc tgcaatgtag tcttgtgtgt     2520

gatttttttt taagttgatg tgcagtctaa ttgttgtttc ataaaagttg gatctgttcc     2580

tatgcccagg atgattttgt gaaccgtgaa gtacgtgaga ctagaagacg cccaaacaag     2640

tcagataata gtaactacaa tggttgctga tgttgagatt attgttgaac tataattaat     2700

aatttggatg gcagaattta tctctttttt gtaaactctc ataactgaat tgcttaagta     2760

taatttatag aatttcagtg cagttcattc ttaatggaaa atctgaaacc taaattgcag     2820

atttaaaagg tactgtacaa ccattatatc tgtaaataac ttagcacctt tttgtcactt     2880

agaataatat gtactactac ttgagtgagc gcttttggaa gttatatcaa gttctagtgt     2940

ttgcttctta gtaactgaac tgaatttaca gttctgtcct agacattttg cactaaagta     3000

gccgaatcca ctctcatgtc ttttcgttaa tgtgctctgt accactggtg agtgctccat     3060

agtttcctta cctgctgcta cagaatgtta ttttacatcc ctatggctat tgccaaggct     3120

acaaaaaagg aaagctatat ttgtatgcaa cactaacctt ttgactgcta atgtatgttt     3180

ctgcttgctg tgccttgtta tggctgcttt ttttgtgcta ataaagtatg tttggtgttc     3240

tccttgtata tctgctgttt tatacatttg caacaatttc tcttgtaaat ggaatggttt     3300

ggggttttta aataagcatt aactaacaac ctttctatag ttaatgcaga gttaatgaac     3360

agtctaatat tgacttatca gaataagcta actctaaatt taatgctcta catcttatca     3420

gtcataatta tatatactgt ggaacagtat ctgtagttac tgcaaattac tgtacagttt     3480

aggttataac agaaaactga cagagaagta ataaacctat tgatttctct gcttataaat     3540

gaaagattga aactatccaa tgacatatta tagtaaatga gtatctgtaa cctcccactg     3600

catcagaagc aggttaaatg aagtcttgtg aatttgtaat agatcagtac catttattgg     3660

tttggggacc atcttaatta aaaataaatg cccaaaatgt agaactttaa ccaaagactt     3720

gtccctttta aagcaaaatg gggattgaag ggacttataa tttctgttgt ttctaattaa     3780

agtccctgaa gatcatatac caaagtgttt gagaacttca tccaaaccta ctttaaagca     3840

ttatgtgcaa ttaagttgtt atgacataat tatattgcct aattgttggg tcttttttct     3900

tgagcttata atgtacctgg aaaataaacc tcttgagaaa aagaaaagtt catactgatt     3960

attggaaaag gactatatat gtgagcaaga ttgtgtttta gagaggaaac ttgaaactcc     4020

aagaaagcac ttgatgtttt tatatgcttg tagcaaattg atgttctaac tgtagtttta     4080

tagaaagtat taatgctttt atgtatttca aaactttcat atgttaaatg gaaattgttt     4140

taaatgtgtt tgagtttatg taagcatgta tacactgtgc taaaagtcac atgtttcagt     4200

ttgtgtataa tattaatatg caatttttgg tttaaatttt tgtcttaaaa tattagtggc     4260

ttacatttta aaaaagaaaa atcaccagca tgaacttgca cctaagtcta tattcactgt     4320

gtccttttct gaatcccatt gtagcctgtc aactaaattt gagtgttaac ggtcttttta     4380

aagtgcattt aaatacaaac caggaatttc tttagaagtt ga                        4422


<210>  21
<211>  535
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Lys Lys Ile Ser Leu Lys Thr Leu Arg Lys Ser Phe Asn Leu Asn 
1               5                   10                  15      


Lys Ser Lys Glu Glu Thr Asp Phe Met Val Val Gln Gln Pro Ser Leu 
            20                  25                  30          


Ala Ser Asp Phe Gly Lys Asp Asp Ser Leu Phe Gly Ser Cys Tyr Gly 
        35                  40                  45              


Lys Asp Met Ala Ser Cys Asp Ile Asn Gly Glu Asp Glu Lys Gly Gly 
    50                  55                  60                  


Lys Asn Arg Ser Lys Ser Glu Ser Leu Met Gly Thr Leu Lys Arg Arg 
65                  70                  75                  80  


Leu Ser Ala Lys Gln Lys Ser Lys Gly Lys Ala Gly Thr Pro Ser Gly 
                85                  90                  95      


Ser Ser Ala Asp Glu Asp Thr Phe Ser Ser Ser Ser Ala Pro Ile Val 
            100                 105                 110         


Phe Lys Asp Val Arg Ala Gln Arg Pro Ile Arg Ser Thr Ser Leu Arg 
        115                 120                 125             


Ser His His Tyr Ser Pro Ala Pro Trp Pro Leu Arg Pro Thr Asn Ser 
    130                 135                 140                 


Glu Glu Thr Cys Ile Lys Met Glu Val Arg Val Lys Ala Leu Val His 
145                 150                 155                 160 


Ser Ser Ser Pro Ser Pro Ala Leu Asn Gly Val Arg Lys Asp Phe His 
                165                 170                 175     


Asp Leu Gln Ser Glu Thr Thr Cys Gln Glu Gln Ala Asn Ser Leu Lys 
            180                 185                 190         


Ser Ser Ala Ser His Asn Gly Asp Leu His Leu His Leu Asp Glu His 
        195                 200                 205             


Val Pro Val Val Ile Gly Leu Met Pro Gln Asp Tyr Ile Gln Tyr Thr 
    210                 215                 220                 


Val Pro Leu Asp Glu Gly Met Tyr Pro Leu Glu Gly Ser Arg Ser Tyr 
225                 230                 235                 240 


Cys Leu Asp Ser Ser Ser Pro Met Glu Val Ser Ala Val Pro Pro Gln 
                245                 250                 255     


Val Gly Gly Arg Ala Phe Pro Glu Asp Glu Ser Gln Val Asp Gln Asp 
            260                 265                 270         


Leu Val Val Ala Pro Glu Ile Phe Val Asp Gln Ser Val Asn Gly Leu 
        275                 280                 285             


Leu Ile Gly Thr Thr Gly Val Met Leu Gln Ser Pro Arg Ala Gly His 
    290                 295                 300                 


Asp Asp Val Pro Pro Leu Ser Pro Leu Leu Pro Pro Met Gln Asn Asn 
305                 310                 315                 320 


Gln Ile Gln Arg Asn Phe Ser Gly Leu Thr Gly Thr Glu Ala His Val 
                325                 330                 335     


Ala Glu Ser Met Arg Cys His Leu Asn Phe Asp Pro Asn Ser Ala Pro 
            340                 345                 350         


Gly Val Ala Arg Val Tyr Asp Ser Val Gln Ser Ser Gly Pro Met Val 
        355                 360                 365             


Val Thr Ser Leu Thr Glu Glu Leu Lys Lys Leu Ala Lys Gln Gly Trp 
    370                 375                 380                 


Tyr Trp Gly Pro Ile Thr Arg Trp Glu Ala Glu Gly Lys Leu Ala Asn 
385                 390                 395                 400 


Val Pro Asp Gly Ser Phe Leu Val Arg Asp Ser Ser Asp Asp Arg Tyr 
                405                 410                 415     


Leu Leu Ser Leu Ser Phe Arg Ser His Gly Lys Thr Leu His Thr Arg 
            420                 425                 430         


Ile Glu His Ser Asn Gly Arg Phe Ser Phe Tyr Glu Gln Pro Asp Val 
        435                 440                 445             


Glu Gly His Thr Ser Ile Val Asp Leu Ile Glu His Ser Ile Arg Asp 
    450                 455                 460                 


Ser Glu Asn Gly Ala Phe Cys Tyr Ser Arg Ser Arg Leu Pro Gly Ser 
465                 470                 475                 480 


Ala Thr Tyr Pro Val Arg Leu Thr Asn Pro Val Ser Arg Phe Met Gln 
                485                 490                 495     


Val Arg Ser Leu Gln Tyr Leu Cys Arg Phe Val Ile Arg Gln Tyr Thr 
            500                 505                 510         


Arg Ile Asp Leu Ile Gln Lys Leu Pro Leu Pro Asn Lys Met Lys Asp 
        515                 520                 525             


Tyr Leu Gln Glu Lys His Tyr 
    530                 535 


<210>  22
<211>  5703
<212>  DNA
<213>  Homo sapiens

<400>  22
agtcgcgccg gcgctgggcg aggaagcgga gccgggccgc ctccggaaaa tggctccaaa       60

ggttaaatga agcaggaaaa atacatagat gcagccttgc agcctctcca gatgtttggg      120

gataatattc cagatagaaa tattgatccc ttggattagg taactagtca taatgaagaa      180

aattagtctt aaaaccttac ggaaatcttt taacttgaat aaaagtaaag aagaaactga      240

tttcatggta gtacaacaac catcgctagc cagtgacttt ggaaaagatg attccttatt      300

tggtagctgc tatggtaaag atatggccag ctgcgatatc aacggtgaag atgaaaaagg      360

cggaaaaaac agatcaaaaa gcgagagcct gatgggtacg ctaaaaaggc ggctttctgc      420

aaaacagaag tcaaaaggca aggcgggcac accctctggg agctctgccg acgaggacac      480

cttctcctcc tcctcagcac ccatagtctt taaagacgtg agagctcaga ggccgataag      540

gtccacgtcg ctccgcagcc atcactacag tcccgcgccg tggcctctgc ggcccacaaa      600

ctccgaggag acctgcatca agatggaggt gagagtcaag gccttggttc actcttccag      660

cccgagtcca gccctgaatg gcgtccggaa ggatttccac gacctccagt ctgagaccac      720

gtgccaggag caagccaatt cactgaagag ctcggcttct cataatggag acctgcatct      780

tcacctggat gaacatgtgc ctgtcgttat tggacttatg cctcaggact acattcagta      840

tactgtgcct ttagatgagg ggatgtatcc tttggaagga tcacggagct attgtctgga      900

cagctcttct cccatggaag tctctgcggt tcctcctcaa gtgggagggc gcgctttccc      960

cgaggatgag agtcaggtag accaggacct agttgtcgcc ccagagatct tcgtggatca     1020

gtccgtgaat ggcttgttga ttggcaccac gggagtcatg ttgcagagcc cgagagcggg     1080

tcacgatgat gtccctccac tctcaccatt gctacctcca atgcagaata atcaaatcca     1140

aaggaacttc agtggactca ctggcacaga agcccacgtg gctgaaagta tgcgctgtca     1200

tttgaatttt gatccgaact ctgctcctgg ggttgcaaga gtttatgact cagtgcaaag     1260

tagtggtccc atggttgtga caagccttac agaggagctg aaaaaacttg caaagcaagg     1320

atggtactgg ggaccaatca cacgttggga ggcagaaggg aagctagcaa acgtgccaga     1380

tggttctttt cttgttcggg acagttctga cgaccgttac cttttaagct tgagctttcg     1440

ctcccatggt aaaacacttc acactagaat tgagcactca aatggtaggt ttagctttta     1500

tgaacagcca gatgtggaag gacatacgtc catagttgat ctaattgagc attcaatcag     1560

ggactctgaa aatggagctt tttgttattc aaggtctcgg ctgcctggat ctgcaactta     1620

ccccgtcaga ctgaccaacc cagtgtcccg gttcatgcag gtgcgctcgt tgcagtacct     1680

gtgtcgtttt gttatacgtc agtataccag aatagactta attcagaaac tgcctttgcc     1740

aaacaaaatg aaggattatt tacaggagaa gcactactga aagattgaga accctgcatc     1800

ttgcactttg ggaataagaa caagagattg aaatacagtt tacaaacttt cattgccatc     1860

aaaatctttt gctgccataa ctatttcagt tttatgtgta aaagagtcat cagtttgttt     1920

aggggtgggg aagtgtcagc aaggtgtctt gggtttattt tggttcttta aaaaagggaa     1980

gtcttgaggt tttagaggtg tgaattatgt ttcatcaatg tgcagaataa tcacaatgtg     2040

aattatcaaa ttctcctcaa tgcccccccc gcccagtcct ttgctgctat ccactgtgat     2100

ttttatgcat taaaagcaca tttcatgtgt attcaaccct aagtaaagtt gaatgaaact     2160

taacagaatg gaaattgcta tgtcttttta aatggtccat tttcaaaaga cagtgttgaa     2220

taaacatacc tgtgtgataa aacacagaat ttacatatac actgaagatg agtttttaat     2280

ctcttacttt aaaaagattt atttagaatc gtgaattgac ataatcttgg gtaatggaac     2340

ggagatctgc aacatatctt ttaacaacac ttttttctaa attatttcta aggttgtgct     2400

aattcttttg gttgtgaaaa gttgaatttt tctgttgcct tcgttttcat cttctagttt     2460

gtctatttta ataaatggcc ttacattaaa aaattgtaaa gaaatgtata ccaccaattt     2520

agaaattgtt gccttttctg taattaaact cgggtacaaa ttggcataac atgaaaacct     2580

atggaactag aattattatt aaagaaatat tagatgatca tagcttcctg tgatagcatt     2640

tttttgtgtg ttacctatcc ttttggtaaa atgttttatc tgtgatttct ttagcttagt     2700

caacattttc ttgggtgaac ttgattgtca actaattttc ataaatggac tggattctct     2760

tgcaacatta atgtttataa aaagttttaa attgatttga atagaaagaa aacattgttt     2820

taaagttgga tttatatttt tcttctatgt agttactata aaagtgtgct ggatttgacc     2880

aatccttacc cccactataa agagaacccg tgatgacttt agtttaaaaa ttgtggaaat     2940

tgtggagcaa tttttctcac aatgtgagaa aaattctaaa ccatattaga taatgtggaa     3000

gtcatattgt ctatcatata tactgccatt taaaaatagg tttttaaaat ttagctaagt     3060

cttaagtaat ttgccgttgc taataatttt atctccttga gtcggttgtt ggggagagat     3120

gttatattca ataattttta gttattttgt aatgcagagt gtttattcat ttcacagttc     3180

tgcaatggat gtagtatttt gggattgccc tgtccagaaa attttcagct acacaccttt     3240

aaaggaaaat gtttctatct cagatgaaac atgtaatttg ggatggttct tcctttgtca     3300

cttaaaggaa gagataggaa aagtctctta cccactttaa acatgagggt aaaggtttag     3360

gtcaaactta ctggctttgt cattcaagca tatctgaatc ctcacttttt tctctttgct     3420

ttttagggtc agaactgaga tattaccaag aaaaggcaca atgccataat attatggtgt     3480

tatggtattt tgacttaaag gggaaaaggt acttaatttt ggtgggatgt tgattgtacc     3540

ttgttaaaaa gactctcatt ttctcatatg ttttctccta ataagatgga atatggagta     3600

tactgtaata atataagtgt tcattataag ctatttggat taagaactat tgcagagttg     3660

taagcttgtt atcaaattaa tgcaagacat ttaaactatt tttttgcaaa actatttatt     3720

tttaaaacaa cttaaagtat atctagggtg agttaaaagt ccctgtgcat ctatattaga     3780

tggcaggttt tgtcacagag tcactgtgta ttaataataa atgttgaaat ggcttctccg     3840

tgtctccaga agcatttaca tgtcctcctt gtgagatcat ggtgcacaga ggtctttgga     3900

ctgccctgaa cccgtcttat gtggacataa cctattccct tcgttttctc atcatgccat     3960

gtgtttaaga tctacccgct tagtgtcaag attattgaga ttttcatcta aatgttttta     4020

aaattgtatt ttgtgtttta gtggaggaca gtcttgatac tgttctaatt cagaaagcca     4080

aattttgatg cgcttttgta tattcataat atatacttta atatgcccta ttctaatcta     4140

gtttgaaatt gttagattct gatagtataa tgataaaatc aaactatttg ccaaaaagtt     4200

aaatttacaa gcagaaagat gttttgcgat attttctact tttgtgtaga aagataacca     4260

tttggggtag gcagcacaac agaatgtgaa agattggctt tatatgatac taacacagtc     4320

cagttaaaag tggaaacagg gaaaagagag agagaaaact catcatttag tttggtctag     4380

acacaatttg gttaaatttt aggattctat tggcagttaa catagatgac atggacacag     4440

cctatgagtg ctttttaaat acgtgcttct aaaaatctga gctcaaagca agaaaaagaa     4500

aacaggaaag ctgtatccat ttgccataat agatgaatca gaattgtttt ctattaaata     4560

tttcatcacg aaatatgatg gaggccagaa gctattttta ggcttactat aacactatta     4620

tgcattttta taaataagaa gaaggctgta gaaagtactt gaaaaatatc taattctctt     4680

tctgtctaag gaaaactctt tctacttggt gcaataatct gaaaatttag aaggtcaaaa     4740

tatgtcacag gaaatgatca tagacctaaa aatagttttt aaggaaacca gctacacggg     4800

gcaaccaacc atcttgctgt tgaagaaaac agttccaaaa ggctaaatca ttggcataaa     4860

ggaaacaaaa cccaaagtat gcgttgtaat tcttgagcca gtattactga aacaggataa     4920

aagttataaa atctaacata ggttaatgca atgtctctgc tagtgctaca agtctaaaat     4980

atctttgtaa caatgctttc agaaatgcca gttttaatta catttcacat tgtatatgag     5040

agatactgct ttatgaatga atcggaataa tacattttca tttaaatctt aattgctttt     5100

cattaaatgc gaagtcttaa tttcaaaatg aaatcacact accagcaata gacagttttc     5160

ttgaaaactc taataaggaa caatagccag ttccgtaaat aactttaaaa ttctaaaagt     5220

gttggtacac tagcaatcac aaatatggtt tcttttaata cttttttaat cctgtaaaga     5280

agggttttta taaacattct ttttattaat cagtcataac atggcgaagt gtgtagttgc     5340

tgtttctgaa aagtgatcca aactctacat ccagagatta tgaaaaattc ttatagaatt     5400

ttgtaacaag tatttacatg ttgggtgaaa gaaatttcat agtcgttgga gtgccatgaa     5460

attaatactt gcaattcaga ttgcggtagt ttacactttt tctgtatgtt tcaaatcagg     5520

tgtgtaccat ttgtactgag aacaccacag aatgaattat ccaaagtcca ttgattttaa     5580

tacgtgtttt ggtttgtaaa caaattatag taatttcttg cacatttttg gaaattaatt     5640

gtataagaat ttatgtatct gcttctagat acagtgtgta aataaaaaat ttcgttcaca     5700

aga                                                                   5703


<210>  23
<211>  645
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Gln Glu Ala Glu Leu Arg Asp Gly Glu Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ser Tyr Arg Val Leu Ser Arg Leu Leu Gly Tyr Gly Glu Ala Ala Pro 
            20                  25                  30          


Glu Pro Gly Pro Pro Pro Pro Pro Pro Gly His Gly Pro Pro Pro Pro 
        35                  40                  45              


Pro Phe Leu Ala Arg Pro Gly Pro Arg Gly Ser Arg Pro Pro Gln Leu 
    50                  55                  60                  


Met Val Phe Arg Asn Val Gly Arg Pro Pro Glu Glu Glu Asp Val Glu 
65                  70                  75                  80  


Ala Ala Pro Glu Pro Gly Pro Ser Glu Leu Leu Cys Pro Arg His Arg 
                85                  90                  95      


Cys Ala Leu Asp Pro Lys Ala Leu Pro Pro Gly Leu Ala Leu Glu Arg 
            100                 105                 110         


Thr Trp Gly Pro Ala Ala Gly Leu Glu Ala Gln Leu Ala Ala Leu Gly 
        115                 120                 125             


Leu Gly Gln Pro Ala Gly Pro Gly Val Lys Thr Val Gly Gly Gly Cys 
    130                 135                 140                 


Cys Pro Cys Pro Cys Pro Pro Gln Pro Pro Pro Pro Gln Pro Gln Pro 
145                 150                 155                 160 


Pro Ala Ala Ala Pro Gln Ala Gly Glu Asp Pro Thr Glu Thr Ser Asp 
                165                 170                 175     


Ala Leu Leu Val Leu Glu Gly Leu Glu Ser Glu Ala Glu Ser Leu Glu 
            180                 185                 190         


Thr Asn Ser Cys Ser Glu Glu Glu Leu Ser Ser Pro Gly Arg Gly Gly 
        195                 200                 205             


Gly Gly Gly Gly Arg Leu Leu Leu Gln Pro Pro Gly Pro Glu Leu Pro 
    210                 215                 220                 


Pro Val Pro Phe Pro Leu Gln Asp Leu Val Pro Leu Gly Arg Leu Ser 
225                 230                 235                 240 


Arg Gly Glu Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro 
                245                 250                 255     


Pro Pro Pro Gly Pro Leu Arg Pro Leu Ala Gly Pro Ser Arg Lys Gly 
            260                 265                 270         


Ser Phe Lys Ile Arg Leu Ser Arg Leu Phe Arg Thr Lys Ser Cys Asn 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Asp Gly Thr Gly Lys Arg Pro Ser Gly Glu 
    290                 295                 300                 


Leu Ala Ala Ser Ala Ala Ser Leu Thr Asp Met Gly Gly Ser Ala Gly 
305                 310                 315                 320 


Arg Glu Leu Asp Ala Gly Arg Lys Pro Lys Leu Thr Arg Thr Gln Ser 
                325                 330                 335     


Ala Phe Ser Pro Val Ser Phe Ser Pro Leu Phe Thr Gly Glu Thr Val 
            340                 345                 350         


Ser Leu Val Asp Val Asp Ile Ser Gln Arg Gly Leu Thr Ser Pro His 
        355                 360                 365             


Pro Pro Thr Pro Pro Pro Pro Pro Arg Arg Ser Leu Ser Leu Leu Asp 
    370                 375                 380                 


Asp Ile Ser Gly Thr Leu Pro Thr Ser Val Leu Val Ala Pro Met Gly 
385                 390                 395                 400 


Ser Ser Leu Gln Ser Phe Pro Leu Pro Pro Pro Pro Pro Pro His Ala 
                405                 410                 415     


Pro Asp Ala Phe Pro Arg Ile Ala Pro Ile Arg Ala Ala Glu Ser Leu 
            420                 425                 430         


His Ser Gln Pro Pro Gln His Leu Gln Cys Pro Leu Tyr Arg Pro Asp 
        435                 440                 445             


Ser Ser Ser Phe Ala Ala Ser Leu Arg Glu Leu Glu Lys Cys Gly Trp 
    450                 455                 460                 


Tyr Trp Gly Pro Met Asn Trp Glu Asp Ala Glu Met Lys Leu Lys Gly 
465                 470                 475                 480 


Lys Pro Asp Gly Ser Phe Leu Val Arg Asp Ser Ser Asp Pro Arg Tyr 
                485                 490                 495     


Ile Leu Ser Leu Ser Phe Arg Ser Gln Gly Ile Thr His His Thr Arg 
            500                 505                 510         


Met Glu His Tyr Arg Gly Thr Phe Ser Leu Trp Cys His Pro Lys Phe 
        515                 520                 525             


Glu Asp Arg Cys Gln Ser Val Val Glu Phe Ile Lys Arg Ala Ile Met 
    530                 535                 540                 


His Ser Lys Asn Gly Lys Phe Leu Tyr Phe Leu Arg Ser Arg Val Pro 
545                 550                 555                 560 


Gly Leu Pro Pro Thr Pro Val Gln Leu Leu Tyr Pro Val Ser Arg Phe 
                565                 570                 575     


Ser Asn Val Lys Ser Leu Gln His Leu Cys Arg Phe Arg Ile Arg Gln 
            580                 585                 590         


Leu Val Arg Ile Asp His Ile Pro Asp Leu Pro Leu Pro Lys Pro Leu 
        595                 600                 605             


Ile Ser Tyr Ile Arg Lys Phe Tyr Tyr Tyr Asp Pro Gln Glu Glu Val 
    610                 615                 620                 


Tyr Leu Ser Leu Lys Glu Ala Gln Leu Ile Ser Lys Gln Lys Gln Glu 
625                 630                 635                 640 


Val Glu Pro Ser Thr 
                645 


<210>  24
<211>  8258
<212>  DNA
<213>  Homo sapiens

<400>  24
ggcttggggg cggtgctcgg cggtggcgga gcgcggcctg ggctcgcgct gggctccgcg       60

cgccccccgc ccccctctat gaggcagagg ccgcggcggc cgttagcgct gtcgctccgg      120

gggccgcggc gggcggggct ccggcggggc ccggcctagt ccccacccca gcccggctcc      180

cagccgcccg ccctccctcc ctctccccga tgcaggaggc cgagctccgg gatggcgagg      240

cggcggcggc ggccgcttcg taccgcgtcc tgagccgcct ccttggctat ggagaggcgg      300

cccccgagcc aggccctccg ccaccgcccc cgggccatgg ccccccgccg ccacccttcc      360

tcgcgcggcc cggcccgcgg ggctcccggc cgccgcagct gatggtgttc cgcaacgtgg      420

gtcggccgcc ggaggaggag gacgtggagg cggccccgga gccgggaccc tcggaactgc      480

tgtgtccccg gcaccgctgt gccctggacc ccaaggccct gccgccgggc ttggcgctcg      540

agcggacctg gggcccggcg gctggactag aggcgcagtt ggcggctctg gggctcgggc      600

agccggcggg gccgggggtc aagacagtcg gtgggggttg ctgcccgtgt ccgtgtcctc      660

ctcagccgcc ccctccgcag ccccagccgc ctgctgccgc cccgcaggcc ggggaggacc      720

ccacggaaac gagcgacgcg ctgctggtcc tggagggctt ggaatcggag gccgagagcc      780

tggagactaa cagctgctcg gaagaggagc tcagcagccc gggtcgcgga ggaggagggg      840

gcggccggct tctgctgcag cccccaggcc ctgaattacc tccggtgccc ttcccgctgc      900

aggacttggt ccctctgggg cgcctgagta gaggggagca gcagcagcag cagcagcagc      960

aacctccccc gcccccgcct cctcccgggc ccctccggcc actcgcgggt ccttctcgga     1020

agggctcctt caaaatccgc ctcagtcgcc tctttcgcac caagagctgc aacggtggct     1080

ccggcggtgg ggatgggacc ggcaagaggc cttctggaga gctggctgct tcagctgcga     1140

gcctgacaga catgggaggc tctgcgggcc gggagctgga cgcggggagg aaacccaagt     1200

tgacaagaac tcaaagtgcc ttttctccgg tctccttcag ccccctgttc acaggtgaaa     1260

ctgtgtcgct tgtggatgtg gacatttctc agcggggcct gacctctcca caccctccaa     1320

ctccccctcc tcctccgaga agaagcctca gcctcctaga tgatatcagt gggacgctgc     1380

ctacatctgt ccttgtggct ccgatggggt cttccttgca gtctttcccc ctacctccgc     1440

ctcctccacc ccatgcccca gatgcatttc cccggattgc tcccatccga gcagctgaat     1500

ccctgcacag ccaaccccca cagcacctcc agtgtcccct ctaccggcct gactcgagca     1560

gctttgcagc cagccttcga gagttggaga agtgtggttg gtattggggg ccaatgaatt     1620

gggaagatgc agagatgaag ctgaaaggga aaccagatgg ttctttcctg gtacgagaca     1680

gttctgatcc tcgttacatc ctgagcctca gtttccgatc acagggtatc acccaccaca     1740

ctagaatgga gcactacaga ggaaccttca gcctgtggtg tcatcccaag tttgaggacc     1800

gctgtcaatc tgttgtagag tttattaaga gagccattat gcactccaag aatggaaagt     1860

ttctctattt cttaagatcc agggttccag gactgccacc aactcctgtc cagctgctct     1920

atccagtgtc ccgattcagc aatgtcaaat ccctccagca cctttgcaga ttccggatac     1980

gacagctcgt caggatagat cacatcccag atctcccact gcctaaacct ctgatctctt     2040

atatccgaaa gttctactac tatgatcctc aggaagaggt atacctgtct ctaaaggaag     2100

cgcagctcat ttccaaacag aagcaagagg tggaaccctc cacgtagcga ggggctccct     2160

gctggtcacc accaagggca tttggttgcc aagctccagc tttgaagaac caaattaagc     2220

taccatgaaa agaagaggaa aagtgaggga acaggaaggt tgggattctc tgtgcagaga     2280

ctttggttcc ccacgcagcc ctggggcttg gaagaagcac atgaccgtac tctgcgtggg     2340

gctccacctc acacccaccc ctgggcatct taggactgga ggggctcctt ggaaaactgg     2400

aagaagtctc aacactgttt ctttttcaga agttttgttt ttgatattta tattacttgg     2460

tatggaaaac tcaccttgaa ggcagttggg gtttgtgccc gttggattga aagtggtgcg     2520

aagggtgagc aggtccaaag aaggggtggg aggagggaac aggggacggc cattcagctg     2580

gtgccaaagg cagagttaga gtctgtgctg tgggcctgga agatgggagg aggggcttga     2640

ggtttgcaaa ggactgggag ttcctgagga agggggaatc tgcctcttgt tgccatgggc     2700

agctgttgta ggagcaggag agaaaggagg gtgggtggtc tcgaaaagaa tattgggcaa     2760

aacctagcca attggcctta gctgggagaa gtagtgactc ctgcatcctt ttttaaggtt     2820

taggaacctg agttcagaaa cacctctcat ggaagctgta ctagttgtga tttacttaat     2880

tccttaagtt ccatgacctg aagttaaccc cgttcttcct ctgctctcaa cccattgccc     2940

cttgagataa ctgtacatgt cactctgatc atggtaacag catccctatt gcttctgcca     3000

gctgtcatgg caatcgtgtt tcccatcacc tgggcggttc agagccagtc atgggctgct     3060

gaatttaatg gagcatgttt ccaggttctt catggcaaac tgtactcatg acttaggagt     3120

gagtgttact tccatgtgcc tgtcagcttg tgagggggaa tgtggaggaa ggtgagaaat     3180

acagctccca cagttgtgct cttcctagag gaagctctca gaacgcagcc ctcacgggat     3240

ttccttaggt cagaggagag catcgcatct cacgttttta ggtttatcac tgccatccca     3300

cttctgggat gggaggtagc aagggcttct gtattttctt gtgttcattc tagcaaccca     3360

gacatttccg gatcagatcc tgctggtctc cactcactgg aaagtctgcc agatgccgat     3420

ttgagagctg cctgtccctg ctttcaggag gagcggggag aaaaactcca atggtcttta     3480

atggtttctg cagctggcca tggccaattc atatgacatt gtgagtttgc tttcttatag     3540

agctgctctg gggagaggtt tgctattgag atgtaacagt ggagctgttg ggtcttcatg     3600

actcctttgc gtgtgttcca tgggactctc tttctgggtt ccccatgctt atagttgcct     3660

cgtgtcacaa gacagatact aatgtcaggt ttgtggcttc ctgatggttt gggtggggcc     3720

ccagtgtcct ggtaatttat aggactgcct catctgggag cattgccttc ttccttagtc     3780

ccacgtggag tgaccagtct tcctccttgt agctgaacag ggaggaaact tgcaccatta     3840

cctgactgtg gaagggtggc ccacaagatg agctgtgcac cataaacaca gcccacctct     3900

gatttgtcat gtggtacctc ttctttcctt ggcttccatg gtagtattat caactaagca     3960

agattgtgat cccagaaatt ggcttagcat gtgagtgttg cctcgtgaga gtacaagtaa     4020

tataactcgc catcttgcag gaagtgccac cccaatatag agcctgaagt tggaatctgt     4080

tgagatcctt gggtggctga tatacagcct gggatctttc ttttttttgt tccttttcaa     4140

ccacccataa ttttaatatt attttttagt gtgtgtgtgc ctggctttgc gctagatatt     4200

gtagaaaaca aaaaaggtaa aagacgtaat atgtggccta agggagcttt taggtgactg     4260

ctgcacatca agcagaaaat caaggactat ctaaagacgt ttatagtaga taagatcagg     4320

gtagaccaga tggtctggga aagttctgtg cctctgaggc tttgggttgt agtcaatggc     4380

aggacagaca gtgagatgaa aaacacatga gcaaaagcaa ggaagcagaa atctgcatgg     4440

catgtactga acagtgcaca gccctgttag agcaacatgg ttaaagaatc ctttccagtg     4500

cggttttcta gatggaagct tcccagccac caggcagacc tgagtgccaa ggggttatga     4560

tggtgaggtg gagcccaaag cccaaaggag tcagcaaggc tcctgcccat tgccagggcc     4620

tcactatggt cagctcaggc catgtgaggg aggcagagcc tctgcacccc ctgtgttact     4680

ggggtttctt ctggagaact catacattca ggtacaaaac aaaccaactg aggaggtgtg     4740

acccaacctc accacccacc tttctcctcc tggggagtgt cgtgttgaac tgtgtctgtg     4800

tcagtgcact ggtcccagcc ctggccgcag cctagtcctt tctctgtgga gtgggctgca     4860

aaacagcagc gcaagaggag acagtcttcg tcaggtgtgg gtgtttggtg cctgcatggg     4920

tggccttgca cagagcagtt aggggaagat gagggggagg catggggctg ggccagctct     4980

ctgggataca gcctggtcag agagtaaatg gagcagagga gcaggtgtgg cagcacctgc     5040

ccttcacctc cctgaccagg cccgtccctc cttcgccagt gctgtgcaga gctcatttaa     5100

atgtattcct ttctaggtct gggcgcggtg gctcacgcct gtaatcccag cactttggga     5160

ggctgaggtg ggtggatcat gaggtcggga gttcaagacc agcttggcca aacagtgaaa     5220

ccctatctct actaaaatac aaaaattagc tgggcatggt ggcatgcgcc tgtagtccca     5280

gctacttggg aggctgagac aggagaattg cttgaaccca ggaggcggag gttgcactga     5340

gccgagattg cgccactgcc ctctagccta gacgacagag tgagactcca tctcaaaaaa     5400

aataaataat ttctttctgg ttgtattttc aagtcacaaa ttggaaaagg cttacatcta     5460

gggacccact gttgattcct aagttgtggg tgggtgatat cagtggcctc agtgcctgca     5520

taaccctcac ctgtttatga ctgatctact gtaaccttcc tcaggttgag agtgagctgc     5580

tgtgagccag tgacaactac tgctacaact tgctgttact tgaaattcgt gtgctatgtt     5640

ggtagcacag gagtaggcgg gcgggggttt tggtgtgggc actaggtaag tgggtggcaa     5700

ccggctcttt gggaccattg gtgctgacct ttgcctggtc acctgcctgt gcctaggcca     5760

agtgaatgtt acatcttgga acctgagcca tggaggtggc gccacctccc tgaggagaaa     5820

ggtgtggcca aaggaaactc ctgcatggct cctgctcctt ccccttccct acatttcact     5880

tgggctaatg atgtaagccc cccttgaggt tggggatggt gtggagatag ctgcagacac     5940

ccctgtaaca gacatccagg aagaattagg gagtgggggt aattatagtt cctaggtcta     6000

ggggtgagag gtgggagtag aaccagaagt gccctggaat ccagccgtgt cagccctcac     6060

cccagggccc ccaggaaagc atggcctgct tgaagccctc tgctccctgc agaaactggg     6120

gcgaggagga gctttttcct tcagttagat ctttcccttc cctgctgcct cgctccctta     6180

gctttggagc cctaaagtta gtggacaaga cactgggata aagctctatg gctgctggaa     6240

ggaggtctga gtctgtgtgt gtgcatatgc atgcatgtgt gtgtgtgtgt gtgtcctcat     6300

ttgcagaagt cttgctacca gttagggtgt taagagcatc tccactgggc ggagacctgg     6360

catttgtttt ccactgttaa gagaatgaca caccccctgt catgtaaggg aggagctatt     6420

gagttagaca ttttccctat gggaatcctc ggtttggttt gtgggaaagg agggaatgga     6480

taagtgattt ttatctctaa tcgtcaacac agctgttctt ccactgaatt tgtgctattg     6540

catacatgta gccatctttc ttttcactgc agcagtgttt atcagtagtt caaaatgatt     6600

tatttgctcc tggggagtaa aacctttttt attaaaaaaa gaaaaagaaa aaaaaaagaa     6660

agaaaagtgt gcccccctcc tatgctgcga tagctataaa atgattgggt cacaaaggtc     6720

aagtctgcac gtccctgtgg tagaccctgc tttcacattg gagccttcac actcagcaca     6780

aaatgattgg aggccttgat aaaatggaga gcaaagtctt gggagcagtg aaatgggggt     6840

tggatcatag agacaggcgc tggggactcg ggtactgcag ttaggaaagt agcgttatga     6900

gttgtactga aaatgttgat tctctaatct gccagaaaag gacctgtctt ttcatgcaga     6960

tttcatattg tctttgtcct tttcattgct tcttgacctt cctggcaggt gtcgctcagt     7020

ttcttcctgt ttcccttcct gtcctctcca cacctgctat cccgtcccac tcccatctac     7080

ctcccgggaa gccagccctg catgctgagt ttgtgacctg cttcattccc atttcatttc     7140

tagagggttt agaggtgacc tggaaccgtt ccctttccct ctcctacccc ctcctctgca     7200

acaccaagag gcctggaggg gcagacagaa agcagccagc cacggcggga agacatgcat     7260

gtttggttgc agctggactg cgatcgtagt tcctcctgga gatagagtgt gaggaactta     7320

ggacactctt cctcagactc tgggatcatc acataccaca ctgccccgct cagagtttcg     7380

tcctgagctc cctaaccagc tcaggtggag cagaagcctg ctctcactcc tccatctctg     7440

gtgctccctt gggcggggac ctgtccctca ctcttaggcc cagaacctgt ccaagggaca     7500

ggtagggtcc aggtgccact ttgggtagct ggctgttgga atgcccacac tggtgctgcc     7560

tgtggcatag ccactgctgt acgtttttgg ttgtttttaa gaaactcgat gaagaggggt     7620

gtcattctgg gctcggggtg gttgccaatt tttcaccaga aagggagcca ccccttgcaa     7680

ccacttctgt ctccgttagc cccccctctg ccctcctcca agccaaagcg tggcctggct     7740

tttgtcttcc catttagttt tcctctttta cccttccttt tgtgcttaat ttattaaaat     7800

agttgctgta taatttattt tcataaacta taaaaaaata ctaaatggtt aaaatagact     7860

tgcaggccaa tcttaaatgg ggtgggaggg gtctgagggt gggatgggga aagggaaaga     7920

ggttttgata taaacaaaac aaatgcactt tgggtgtgtt ttggtatttt tctggggata     7980

gagggggtgg ggttagggat gtccctgtag attagttcca gaatggggtg tctgtatata     8040

ctgtattaat aggcatgttt gactctcgta aagggacgtt agtagctgct gcaggtcctg     8100

tttggaaacc ccatgtacaa ttcccagttt tttgtaagtg tcagtgcgag agacatttga     8160

ctcttgtgtt tgtatctcct ttttatgatt gctgtaccta cccatgtctt tttggggagg     8220

ggtgaaaaga gatttgaaat aaaaatgttt agaaatta                             8258


<210>  25
<211>  22
<212>  RNA
<213>  Mus musculus

<400>  25
cauugcacuu gucucggucu ga                                                22


<210>  26
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mir mimic

<400>  26
cauugcacuu gucucggucu ga                                                22


<210>  27
<211>  20
<212>  RNA
<213>  Mus musculus

<400>  27
uaaggcacgc ggugaaugcc                                                   20


<210>  28
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mir mimic

<400>  28
uaaggcacgc ggugaaugcc                                                   20


<210>  29
<211>  22
<212>  RNA
<213>  Mus musculus

<400>  29
ugagguagua gguuguauag uu                                                22


<210>  30
<211>  22
<212>  RNA
<213>  Mus musculus

<400>  30
ugagguagua gguuguaugg uu                                                22


<210>  31
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic antagomir

<400>  31
ugagguagua gguuguauag uu                                                22


<210>  32
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic antagomir

<400>  32
ugagguagua gguuguaugg uu                                                22


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  33
ggcattgctc tcaatgacaa                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  34
cttgctcagt gtccttgctg                                                   20


<210>  35
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  35
tacgacatga acggctgcta ctca                                              24


<210>  36
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  36
ttacatgctg caggatctcc acct                                              24


<210>  37
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Motif

<400>  37
vcasctgm                                                                 8


<210>  38
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Motif

<400>  38
thvdbasaav rw                                                           12


<210>  39
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Motif


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<400>  39
nwkscsabad                                                              10


<210>  40
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Predicted miRNA sites in Dkk3

<400>  40
ccagcugagu cacugguaga ugugcaaua                                         29


<210>  41
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  predicted miR-25 sites

<400>  41
agucuggcuc uguucacguu ac                                                22


<210>  42
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  predicted miR-25 sites

<400>  42
gauacuguaa caaaacggcu gaagcaaug                                         29


<210>  43
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  predicted miR-25 sites

<400>  43
agucuggcuc uguucacguu ac                                                22


<210>  44
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  predicted miR-25 sites

<400>  44
cuuucuggcu aacaggagag ugggcaaug                                         29


<210>  45
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  predicted miR-25 sites

<400>  45
agucuggcuc uguucacguu ac                                                22


<210>  46
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  let-7 sites in Klf4 3'UTR

<400>  46
cggaggaaga ggaagcgauu cagguacag                                         29


<210>  47
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  let-7 sites in Klf4 3'UTR

<400>  47
ccuuucgauc uuccaacaug uc                                                22


<210>  48
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  let-7 sites in Klf4 3'UTR

<400>  48
ugguuucaga ugugcaauaa uuuguacaa                                         29


<210>  49
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  let-7 sites in Klf4 3'UTR

<400>  49
uucgaucuuc caacauguc                                                    19


<210>  50
<211>  2295
<212>  DNA
<213>  Homo sapiens

<400>  50
gccagacacg cagccactga accacaagca gcttcgcgtt aactggagtg cctgggagtc       60

gcgtgccagg agccgcacgg ccagggactg actgacagac agacacgcac caccaccaca      120

acacacgaga cccgggcggg ccgccgccgc cgccgccggg gctcttggca aactcgccgg      180

tcgcagaggt cccccgcgga gctgcgccac agtagcgccg ggcttgcagc tttcacgccg      240

ggcgaaggac ccggcgctgc gctcgcagct gcgcggagat tcccggcaca ggccaaagtc      300

acagcaacgc tgaggcacag ttagagccaa ctaagatgtt cgtcaaatcc gagaccttgg      360

agttgaagga ggaagaggac gtgttagtgc tgctcggatc ggcctccccc gccttggcgg      420

ccctgacccc gctgtcatcc agcgccgacg aagaagagga ggaggagccg ggcgcgtcag      480

gcggggcgcg tcggcagcgc ggggctgagg ccgggcaggg ggcgcggggc ggcgtggctg      540

cgggtgcgga gggctgccgg cccgcacggc tgctgggtct ggtacacgat tgcaaacggc      600

gcccttcccg ggcgcgggcc gtctcccgag gcgccaagac ggccgagacg gtgcagcgca      660

tcaagaagac ccgtagactg aaggccaaca accgcgagcg aaaccgcatg cacaacctca      720

acgcggcact ggacgcgctg cgcgaggtgc tccccacgtt ccccgaggac gccaagctca      780

ccaagatcga gaccctgcgc ttcgcccaca actacatctg ggcactcacc gagaccctgc      840

gcctggcgga tcactgcggg ggcggcggcg ggggcctgcc gggggcgctc ttctccgagg      900

cagtgttgct gagcccggga ggagccagcg ccgccctgag cagcagcgga gacagcccct      960

cgcccgcctc cacgtggagt tgcaccaaca gccccgcgcc gtcctcctcc gtgtcctcca     1020

attccacctc cccctacagc tgcactttat cgcccgccag cccggccggg tcagacatgg     1080

actattggca gcccccacct cccgacaagc accgctatgc acctcacctc cccatagcca     1140

gggattgtat ctagagctgc catttctgct acccacgcca ggccttagtg ggttcccttt     1200

cctgtcccca gtcgagccct cctcccttcc cctgcccctc ctttccacgc cctggaaacc     1260

atctcacttc acagggcagg tgtagccttt ctgattcctc ggttgtttct tgcatttctt     1320

ggctttgggt atccttcatt cagacgggct ctgatttact gaaggtgtga tggagcttat     1380

tgtcaaagcc aagggtggcg ttttgggggc gcttcttgag acgaaaaaga ccctgggaag     1440

agatgatggt ggcatatcta aagagtttgc agagcggact gacgctcctc ccctttctct     1500

ttaacgccga aggacttggt gcagttcgtg tgaatctcac agggggaatg caactggttc     1560

ctgtgatctc ttcacctttg cttctacata gagatgttaa tgtcgagtag aaagaaatgt     1620

atcttagcat ctgaatgatt ttgctggtaa taatattatc cacagatttg caatggctgg     1680

catctgcttt attcccattg ctgtctgcag gctgtgggaa tttcacctgt caaaccaaac     1740

ttccctctct gatgtgcact ttgttctgtt tcccagattc gtcacaatgc ctattgtcct     1800

gtccttctct ttcctttttc ttccccattt tgccatctgt ctcttatgat ttataagggg     1860

aaaaaaactt gttttgttag aggggcaggt tagaagtcat tgtataattt gtaggctttg     1920

taatgattga atgcaagcgt ggaaatttag gctgaactct ctatcaaaag gaaaaatgtg     1980

gaggaaaagg gaaaaatcag gagggaggat tgcctcatgt attatttatt tcgacctttt     2040

aggggagaag gaactccccc attctttcaa gagattaaaa ataaatcaac agtctgaaaa     2100

cctaagcaga cacggagcat tatccggatc agccacacac gtgttccctt ctatttatta     2160

taaagaaatt tttcatggga aaatatgtat tttttgtata ttctacagag tttattctag     2220

tatgtattta catcttgaag aacaagaaag ttgttcttgt gattaaacta taaataaact     2280

atctaatttt cataa                                                      2295


<210>  51
<211>  1200
<212>  DNA
<213>  Homo sapiens

<400>  51
gttcgttgca acaaattgat gagcaatgct tttttataat gccaactttg tacaaaaaag       60

ttggcatgac caaatcgtac agcgagagtg ggctgatggg cgagcctcag ccccaaggtc      120

ctccaagctg gacagacgag tgtctcagtt ctcaggacga ggagcacgag gcagacaaga      180

aggaggacga cctcgaagcc atgaacgcag aggaggactc actgaggaac gggggagagg      240

aggaggacga agatgaggac ctggaagagg aggaagaaga ggaagaggag gatgacgatc      300

aaaagcccaa gagacgcggc cccaaaaaga agaagatgac taaggctcgc ctggagcgtt      360

ttaaattgag acgcatgaag gctaacgccc gggagcggaa ccgcatgcac ggactgaacg      420

cggcgctaga caacctgcgc aaggtggtgc cttgctattc taagacgcag aagctgtcca      480

aaatcgagac tctgcgcttg gccaagaact acatctgggc tctgtcggag atcctgcgct      540

caggcaaaag cccagacctg gtctccttcg ttcagacgct ttgcaagggc ttatcccaac      600

ccaccaccaa cctggttgcg ggctgcctgc aactcaatcc tcggactttt ctgcctgagc      660

agaaccagga catgcccccc cacctgccga cggccagcgc ttccttccct gtacacccct      720

actcctacca gtcgcctggg ctgcccagtc cgccttacgg taccatggac agctcccatg      780

tcttccaggt taagcctccg ccgcacgcct acagcgcagc gctggagccc ttctttgaaa      840

gccctctgac tgattgcacc agcccttcct ttgatggacc cctcagcccg ccgctcagca      900

tcaatggcaa cttctctttc aaacacgaac cgtccgccga gtttgagaaa aattatgcct      960

ttaccatgca ctatcctgca gcgacactgg caggggccca aagccacgga tcaatcttct     1020

caggcaccgc tgcccctcgc tgcgagatcc ccatagacaa tattatgtcc ttcgatagcc     1080

attcacatca tgagcgagtc atgagtgccc agctcaatgc catatttcat gattacccaa     1140

ctttcttgta caaagttggc attataagaa agcattgctt atcaatttgt tgcaacgaac     1200


