                         SEQUENCE LISTING

<110>  The Broad Institute, Inc.
 
<120>  AFFINITY-BASED MULTIPLEXING FOR LIVE-CELL MONITORING OF COMPLEX 
       CELL POPULATIONS

<130>  52199-546001WO

<140>  PCT/US2020/030286
<141>  2020-04-28

<150>  62/840,373
<151>  2019-04-29

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  538
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1

Met Gly Gln Ala Val Thr Thr Pro Leu Ser Leu Thr Leu Asp His Trp 
1               5                   10                  15      


Lys Asp Val Glu Arg Thr Ala His Asn Leu Ser Val Glu Val Arg Lys 
            20                  25                  30          


Arg Arg Trp Val Thr Phe Cys Ser Ala Glu Trp Pro Thr Phe Asn Val 
        35                  40                  45              


Gly Trp Pro Arg Asp Gly Thr Phe Asn Pro Asp Ile Ile Thr Gln Val 
    50                  55                  60                  


Lys Ile Lys Val Phe Ser Pro Gly Pro His Gly His Pro Asp Gln Val 
65                  70                  75                  80  


Pro Tyr Ile Val Thr Trp Glu Ala Ile Ala Val Asp Pro Pro Pro Trp 
                85                  90                  95      


Val Arg Pro Phe Val His Pro Lys Pro Pro Leu Ser Leu Pro Pro Ser 
            100                 105                 110         


Ala Pro Ser Leu Pro Pro Glu Pro Pro Leu Ser Thr Pro Pro Gln Ser 
        115                 120                 125             


Ser Leu Tyr Pro Ala Leu Thr Ser Pro Leu Asn Thr Lys Pro Arg Pro 
    130                 135                 140                 


Gln Val Leu Pro Asp Ser Gly Gly Pro Leu Ile Asp Leu Leu Thr Glu 
145                 150                 155                 160 


Asp Pro Pro Pro Tyr Arg Asp Pro Gly Pro Pro Ser Pro Asp Gly Asn 
                165                 170                 175     


Gly Asp Ser Gly Glu Val Ala Pro Thr Glu Gly Ala Pro Asp Pro Ser 
            180                 185                 190         


Pro Met Val Ser Arg Leu Arg Gly Arg Lys Glu Pro Pro Val Ala Asp 
        195                 200                 205             


Ser Thr Thr Ser Gln Ala Phe Pro Leu Arg Leu Gly Gly Asn Gly Gln 
    210                 215                 220                 


Tyr Gln Tyr Trp Pro Phe Ser Ser Ser Asp Leu Tyr Asn Trp Lys Asn 
225                 230                 235                 240 


Asn Asn Pro Ser Phe Ser Glu Asp Pro Ala Lys Leu Thr Ala Leu Ile 
                245                 250                 255     


Glu Ser Val Leu Leu Thr His Gln Pro Thr Trp Asp Asp Cys Gln Gln 
            260                 265                 270         


Leu Leu Gly Thr Leu Leu Thr Gly Glu Glu Lys Gln Arg Val Leu Leu 
        275                 280                 285             


Glu Ala Arg Lys Ala Val Arg Gly Glu Asp Gly Arg Pro Thr Gln Leu 
    290                 295                 300                 


Pro Asn Asp Ile Asn Asp Ala Phe Pro Leu Glu Arg Pro Asp Trp Asp 
305                 310                 315                 320 


Tyr Asn Thr Gln Arg Gly Arg Asn His Leu Val His Tyr Arg Gln Leu 
                325                 330                 335     


Leu Leu Ala Gly Leu Gln Asn Ala Gly Arg Ser Pro Thr Asn Leu Ala 
            340                 345                 350         


Lys Val Lys Gly Ile Thr Gln Gly Pro Asn Glu Ser Pro Ser Ala Phe 
        355                 360                 365             


Leu Glu Arg Leu Lys Glu Ala Tyr Arg Arg Tyr Thr Pro Tyr Asp Pro 
    370                 375                 380                 


Glu Asp Pro Gly Gln Glu Thr Asn Val Ala Met Ser Phe Ile Trp Gln 
385                 390                 395                 400 


Ser Ala Pro Asp Ile Gly Arg Lys Leu Glu Arg Leu Glu Asp Leu Lys 
                405                 410                 415     


Ser Lys Thr Leu Gly Asp Leu Val Arg Glu Ala Glu Lys Ile Phe Asn 
            420                 425                 430         


Lys Arg Glu Thr Pro Glu Glu Arg Glu Glu Arg Ile Arg Arg Glu Thr 
        435                 440                 445             


Glu Glu Lys Glu Glu Arg Arg Arg Ala Glu Asp Val Gln Arg Glu Lys 
    450                 455                 460                 


Glu Arg Asp Arg Arg Arg His Arg Glu Met Ser Lys Leu Leu Ala Thr 
465                 470                 475                 480 


Val Val Ser Gly Gln Arg Gln Asp Arg Gln Gly Gly Glu Arg Arg Arg 
                485                 490                 495     


Pro Gln Leu Asp His Asp Gln Cys Ala Tyr Cys Lys Glu Lys Gly His 
            500                 505                 510         


Trp Ala Arg Asp Cys Pro Lys Lys Pro Arg Gly Pro Arg Gly Pro Arg 
        515                 520                 525             


Pro Gln Ala Ser Leu Leu Thr Leu Asp Asp 
    530                 535             


<210>  2
<211>  511
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
            20                  25                  30          


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
        35                  40                  45              


His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser 
    50                  55                  60                  


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
65                  70                  75                  80  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
                85                  90                  95      


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
            100                 105                 110         


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
    130                 135                 140                 


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
145                 150                 155                 160 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr 
                165                 170                 175     


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
            180                 185                 190         


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 


Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys 
225                 230                 235                 240 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
                245                 250                 255     


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
            260                 265                 270         


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
            340                 345                 350         


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
        355                 360                 365             


Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
385                 390                 395                 400 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
                405                 410                 415     


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
            420                 425                 430         


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
    450                 455                 460                 


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
465                 470                 475                 480 


Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys 
                485                 490                 495     


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            500                 505                 510     


<210>  3
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  4
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  4

His His His His His His 
1               5       


<210>  5
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  5

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  6
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  6

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  7
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  7

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  8
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  8

Asp Thr Tyr Arg Tyr Ile 
1               5       


<210>  9
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  9

Thr Asp Phe Tyr Leu Lys 
1               5       


<210>  10
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  10

Glu Tyr Met Pro Met Glu 
1               5       


<210>  11
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  11

Ser Gly Phe Ala Asn Glu Leu Gly Pro Arg Leu Met Gly Lys 
1               5                   10                  


<210>  12
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  12

Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly 
1               5                   10      


<210>  13
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  13

Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


<210>  14
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  14

Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg 
1               5                   10              


<210>  15
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  15

Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser 
1               5                   10                  15  


<210>  16
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  16

Ser Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp 
1               5                   10          


<210>  17
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  17

Lys Pro Pro Thr Pro Pro Pro Glu Pro Glu Thr 
1               5                   10      


<210>  18
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  18

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  19
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  19

Cys Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15      


<210>  20
<211>  576
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  20
tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg cgttacataa       60

cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata      120

atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag      180

tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc      240

cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta      300

tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg      360

cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg atttccaagt      420

ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca      480

aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt acggtgggag      540

gtctatataa gcagagctgg tttagtgaac cgtcag                                576


<210>  21
<211>  495
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  21

Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
1               5                   10                  15      


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
            20                  25                  30          


His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser 
        35                  40                  45              


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
    50                  55                  60                  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
65                  70                  75                  80  


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
                85                  90                  95      


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
            100                 105                 110         


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
        115                 120                 125             


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
    130                 135                 140                 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr 
145                 150                 155                 160 


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
                165                 170                 175     


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
            180                 185                 190         


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
        195                 200                 205             


Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys 
    210                 215                 220                 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
225                 230                 235                 240 


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
                245                 250                 255     


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
            260                 265                 270         


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
        275                 280                 285             


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
    290                 295                 300                 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
305                 310                 315                 320 


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
                325                 330                 335     


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
            340                 345                 350         


Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
        355                 360                 365             


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
    370                 375                 380                 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
385                 390                 395                 400 


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
                405                 410                 415     


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
            420                 425                 430         


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
        435                 440                 445             


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
    450                 455                 460                 


Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys 
465                 470                 475                 480 


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
                485                 490                 495 


<210>  22
<211>  495
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  22

Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
1               5                   10                  15      


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
            20                  25                  30          


His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Ala Ser 
        35                  40                  45              


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
    50                  55                  60                  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
65                  70                  75                  80  


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
                85                  90                  95      


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
            100                 105                 110         


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
        115                 120                 125             


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
    130                 135                 140                 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr 
145                 150                 155                 160 


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
                165                 170                 175     


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
            180                 185                 190         


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
        195                 200                 205             


Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys 
    210                 215                 220                 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
225                 230                 235                 240 


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
                245                 250                 255     


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
            260                 265                 270         


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
        275                 280                 285             


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
    290                 295                 300                 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
305                 310                 315                 320 


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
                325                 330                 335     


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
            340                 345                 350         


Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
        355                 360                 365             


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
    370                 375                 380                 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
385                 390                 395                 400 


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
                405                 410                 415     


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
            420                 425                 430         


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
        435                 440                 445             


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
    450                 455                 460                 


Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys 
465                 470                 475                 480 


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
                485                 490                 495 


<210>  23
<211>  495
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  23

Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
1               5                   10                  15      


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
            20                  25                  30          


His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser 
        35                  40                  45              


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
    50                  55                  60                  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
65                  70                  75                  80  


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
                85                  90                  95      


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
            100                 105                 110         


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
        115                 120                 125             


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
    130                 135                 140                 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr 
145                 150                 155                 160 


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
                165                 170                 175     


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
            180                 185                 190         


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
        195                 200                 205             


Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys 
    210                 215                 220                 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
225                 230                 235                 240 


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
                245                 250                 255     


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
            260                 265                 270         


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
        275                 280                 285             


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
    290                 295                 300                 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
305                 310                 315                 320 


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
                325                 330                 335     


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
            340                 345                 350         


Glu Ala Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
        355                 360                 365             


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
    370                 375                 380                 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
385                 390                 395                 400 


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
                405                 410                 415     


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
            420                 425                 430         


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
        435                 440                 445             


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
    450                 455                 460                 


Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys 
465                 470                 475                 480 


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
                485                 490                 495 


<210>  24
<211>  3604
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  24
acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc       60

atattggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac      120

gacccccgcc ccttgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact      180

ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa      240

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg      300

cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta      360

gtcatcgcta ttaccatggt gatgcggttg tggcagtaca tcaatgggcg tggatagcgg      420

tttgactcac ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg      480

caccaaaatc aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg      540

ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ctcgtttagt gaaccgtcag      600

atcgcctgga gacgccatcc acgctgtttt gacctccata gaagacaccg ggaccgatcc      660

agcctcccct cgaagcttta catgtggtac cgagctcgga tcctgagaac ttcagggtga      720

gtctatggga cccttgatgt tttctttccc cttcttttct atggttaagt tcatgtcata      780

ggaaggggag aagtaacagg gtacacatat tgaccaaatc agggtaattt tgcatttgta      840

attttaaaaa atgctttctt cttttaatat acttttttgt ttatcttatt tctaatactt      900

tccctaatct ctttctttca gggcaataat gatacaatgt atcatgcctc tttgcaccat      960

tctaaagaat aacagtgata atttctgggt taaggcaata gcaatatttc tgcatataaa     1020

tatttctgca tataaattgt aactgatgta agaggtttca tattgctaat agcagctaca     1080

atccagctac cattctgctt ttattttatg gttgggataa ggctggatta ttctgagtcc     1140

aagctaggcc cttttgctaa tcatgttcat acctcttatc ttcctcccac agctcctggg     1200

caacgtgctg gtctgtgtgc tggcccatca ctttggcaaa gaattcgcca ccatgggcca     1260

gactgttacc actcccttaa gtttgacctt aggtcactgg aaagatgtcg agcggatcgc     1320

tcacaaccag tcggtagatg tcaagaagag acgttgggtt accttctgct ctgcagaatg     1380

gccaaccttt aacgtcggat ggccgcgaga cggcaccttt aaccgagacc tcatcaccca     1440

ggttaagatc aaggtctttt cacctggccc gcatggacac ccagaccagg tcccctacat     1500

cgtgacctgg gaagccttgg cttttgaccc ccctccctgg gtcaagccct ttgtacaccc     1560

taagcctccg cctcctcttc ctccatccgc cccgtctctc ccccttgaac ctcctcgttc     1620

gaccccgcct cgatcctccc tttatccagc cctcactcct tctctaggcg ccaaacctaa     1680

acctcaagtt ctttctgaca gtggggggcc gctcatcgac ctacttacag aagacccccc     1740

gccttatagg gacccaagac cacccccttc cgacagggac ggaaatggtg gagaagcgac     1800

ccctgcggga gaggcaccgg acccctcccc aatggcatct cgcctacgtg ggagacggga     1860

gccccctgtg gccgactcca ctacctcgca ggcattcccc ctccgcgcag gaggaaacgg     1920

acagcttcaa tactggccgt tctcctcttc tgacctttac aactggaaaa ataataaccc     1980

ttctttttct gaagatccag gtaaactgac agctctgatc gagtctgtcc tcatcaccca     2040

tcagcccacc tgggacgact gtcagcagct gttggggact ctgctgaccg gagaagaaaa     2100

acaacgggtg ctcttagagg ctagaaaggc ggtgcggggc gatgatgggc gccccactca     2160

actgcccaat gaagtcgatg ccgcttttcc cctcgagcgc ccagactggg attacaccac     2220

ccaggcaggt aggaaccacc tagtccacta tcgccagttg ctcctagcgg gtctccaaaa     2280

cgcgggcaga agccccacca atttggccaa ggtaaaagga ataacacaag ggcccaatga     2340

gtctccctcg gccttcctag agagacttaa ggaagcctat cgcaggtaca ctccttatga     2400

ccctgaggac ccagggcaag aaactaatgt gtctatgtct ttcatttggc agtctgcccc     2460

agacattggg agaaagttag agaggttaga agatttaaaa aacaagacgc ttggagattt     2520

ggttagagag gcagaaaaga tctttaataa acgagaaacc ccggaagaaa gagaggaacg     2580

tatcaggaga gaaacagagg aaaaagaaga acgccgtagg acagaggatg agcagaaaga     2640

gaaagaaaga gatcgtagga gacatagaga gatgagcaag ctattggcca ctgtcgttag     2700

tggacagaaa caggatagac agggaggaga acgaaggagg tcccaactcg atcgcgacca     2760

gtgtgcctac tgcaaagaaa aggggcactg ggctaaagat tgtcccaaga aaccacgagg     2820

acctcgggga ccaagaccgc agggatccgg cgcaacaaac ttctctctgc tgaaacaagc     2880

cggagatgtc gaagagaatc ctggaccgat ggagagcgac gagagcggcc tgcccgccat     2940

gaagatcgag tgccgcatca ccggcaccct gaacggcgtg gagttcgagc tggtgggcgg     3000

cggagagggc acccccgagc agggccgcat gaccaacaag atgaagagca ccaaaggcgc     3060

cctgaccttc agcccctacc tgctgagcca cgtgatgggc tacggcttct accacttcgg     3120

cacctacccc agcggctacg agaacccctt cctgcacgcc atcaacaacg gcggctacac     3180

caacacccgc atcgagaagt acgaggacgg cggcgtgctg cacgtgagct tcagctaccg     3240

ctacgaggcc ggccgcgtga tcggcgactt caaggtggtg ggcaccggct tccccgagga     3300

cagcgtgatc ttcaccgaca agatcatccg cagcaacgcc accgtggagc acctgcaccc     3360

catgggcgat aacgtgctgg tgggcagctt cgcccgcacc ttcagcctgc gcgacggcgg     3420

ctactacagc ttcgtggtgg acagccacat gcacttcaag agcgccatcc accccagcat     3480

cctgcagaac gggggcccca tgttcgcctt ccgccgcgtg gaggagctgc acagcaacac     3540

cgagctgggc atcgtggagt accagcacgc cttcaagacc ccggatgcag atgccggtga     3600

agaa                                                                  3604


<210>  25
<211>  3613
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  25
acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc       60

atattggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac      120

gacccccgcc ccttgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact      180

ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa      240

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg      300

cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta      360

gtcatcgcta ttaccatggt gatgcggttg tggcagtaca tcaatgggcg tggatagcgg      420

tttgactcac ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg      480

caccaaaatc aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg      540

ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ctcgtttagt gaaccgtcag      600

atcgcctgga gacgccatcc acgctgtttt gacctccata gaagacaccg ggaccgatcc      660

agcctcccct cgaagcttta catgtggtac cgagctcgga tcctgagaac ttcagggtga      720

gtctatggga cccttgatgt tttctttccc cttcttttct atggttaagt tcatgtcata      780

ggaaggggag aagtaacagg gtacacatat tgaccaaatc agggtaattt tgcatttgta      840

attttaaaaa atgctttctt cttttaatat acttttttgt ttatcttatt tctaatactt      900

tccctaatct ctttctttca gggcaataat gatacaatgt atcatgcctc tttgcaccat      960

tctaaagaat aacagtgata atttctgggt taaggcaata gcaatatttc tgcatataaa     1020

tatttctgca tataaattgt aactgatgta agaggtttca tattgctaat agcagctaca     1080

atccagctac cattctgctt ttattttatg gttgggataa ggctggatta ttctgagtcc     1140

aagctaggcc cttttgctaa tcatgttcat acctcttatc ttcctcccac agctcctggg     1200

caacgtgctg gtctgtgtgc tggcccatca ctttggcaaa gaattcgcca ccatgaagtg     1260

ccttttgtac ttagcctttt tattcattgg ggtgaattgc aagttcacca tagtttttcc     1320

atccggagga gattacaagg atgacgacga taagggcgga agcttgggac acaaccaaaa     1380

aggaaactgg aaaaatgttc cttctaatta ccattattgc ccgtcaagct cagatttaaa     1440

ttggcataat gacttaatag gcacagcctt acaagtcaaa atgcccgcga gtcacaaggc     1500

tattcaagca gacggttgga tgtgtcatgc ttccaaatgg gtcactactt gtgatttccg     1560

ctggtatgga ccgaagtata taacacattc catccgatcc ttcactccat ctgtagaaca     1620

atgcaaggaa agcattgaac aaacgaaaca aggaacttgg ctgaatccag gcttccctcc     1680

tcaaagttgt ggatatgcaa ctgtgacgga tgccgaagca gtgattgtcc aggtgactcc     1740

tcaccatgtg ctggttgatg aatacacagg agaatgggtt gattcacagt tcatcaacgg     1800

aaaatgcagc aattacatat gccccactgt ccataactct acaacctggc attctgacta     1860

taaggtcaaa gggctatgtg attctaacct catttccatg gacatcacct tcttctcaga     1920

ggacggagag ctatcatccc tgggaaagga gggcacaggg ttcagaagta actactttgc     1980

ttatgaaact ggaggcaagg cctgcaaaat gcaatactgc aagcattggg gagtcagact     2040

cccatcaggt gtctggttcg agatggctga taaggatctc tttgctgcag ccagattccc     2100

tgaatgccca gaagggtcaa gtatctctgc tccatctcag acctcagtgg atgtaagtct     2160

aattcaggac gttgagagga tcttggatta ttccctctgc caagaaacct ggagcaaaat     2220

cagagcgggt cttccaatct ctccagtgga tctcagctat cttgctccta aaaacccagg     2280

aaccggtcct gctttcacca taatcaatgg taccctaaaa tactttgaga ccagatacat     2340

cagagtcgat attgctgctc caatcctctc aagaatggtc ggaatgatca gtggaactac     2400

cacagaagcg gaactgtggg atgactgggc accatatgaa gacgtggaaa ttggacccaa     2460

tggagttctg aggaccagtt caggatataa gtttccttta tacatgattg gacatggtat     2520

gttggactcc gatcttcatc ttagctcaaa ggctcaggtg ttcgaacatc ctcacattca     2580

agacgctgct tcgcaacttc ctgatgatga gagtttattt tttggtgata ctgggctatc     2640

caaaaatcca atcgagcttg tagaaggttg gttcagtagt tggaaaagct ctattgcctc     2700

ttttttcttt atcatagggt taatcattgg actattcttg gttctccgag ttggtatcca     2760

tctttgcatt aaattaaagc acaccaagaa aagacagatt tatacagaca tagagatgaa     2820

ccgacttgga aaggaattcg gatccggcgc aacaaacttc tctctgctga aacaagccgg     2880

agatgtcgaa gagaatcctg gaccgatggt gtccaagggc gaggaagata acatggccat     2940

catcaaggag ttcatgaggt ttaaggtcca catggagggt tcagtcaatg gccacgagtt     3000

cgagattgaa ggcgagggcg agggccgccc ctacgaaggg acacagacgg cgaaattgaa     3060

ggtgaccaaa ggcgggccat tgcccttcgc atgggacatc ttgtcccctc agtttatgta     3120

tggcagcaag gcctatgtta agcaccccgc tgatatcccg gactacttga agctgtcctt     3180

tccagagggg tttaaatggg agcgcgttat gaatttcgaa gacggaggag tggttacggt     3240

gacgcaggac tcatccctgc aggacggaga atttatatat aaggttaagt tgagaggcac     3300

aaacttccca agcgacggcc ctgtgatgca gaagaaaaca atggggtggg aagcttccag     3360

cgagcgcatg taccccgaag atggcgccct caagggcgag ataaagcaaa ggctgaaact     3420

taaggacggc ggtcattacg acgcggaggt caagacaact tacaaggcta aaaaacccgt     3480

tcagttgcct ggggcttaca atgttaatat caaacttgac atcacaagcc acaatgaaga     3540

ctatacgatc gtggagcagt atgaacgagc ggaaggcagg cactcaacgg gggggatgga     3600

cgagctttac aag                                                        3613


<210>  26
<211>  3616
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  26
acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc       60

atattggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac      120

gacccccgcc ccttgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact      180

ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa      240

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg      300

cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta      360

gtcatcgcta ttaccatggt gatgcggttg tggcagtaca tcaatgggcg tggatagcgg      420

tttgactcac ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg      480

caccaaaatc aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg      540

ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ctcgtttagt gaaccgtcag      600

atcgcctgga gacgccatcc acgctgtttt gacctccata gaagacaccg ggaccgatcc      660

agcctcccct cgaagcttta catgtggtac cgagctcgga tcctgagaac ttcagggtga      720

gtctatggga cccttgatgt tttctttccc cttcttttct atggttaagt tcatgtcata      780

ggaaggggag aagtaacagg gtacacatat tgaccaaatc agggtaattt tgcatttgta      840

attttaaaaa atgctttctt cttttaatat acttttttgt ttatcttatt tctaatactt      900

tccctaatct ctttctttca gggcaataat gatacaatgt atcatgcctc tttgcaccat      960

tctaaagaat aacagtgata atttctgggt taaggcaata gcaatatttc tgcatataaa     1020

tatttctgca tataaattgt aactgatgta agaggtttca tattgctaat agcagctaca     1080

atccagctac cattctgctt ttattttatg gttgggataa ggctggatta ttctgagtcc     1140

aagctaggcc cttttgctaa tcatgttcat acctcttatc ttcctcccac agctcctggg     1200

caacgtgctg gtctgtgtgc tggcccatca ctttggcaaa gaattcgcca ccatgaagtg     1260

ccttttgtac ttagcctttt tattcattgg ggtgaattgc aagttcacca tagtttttcc     1320

atccggagga tacccatacg atgttccaga ttacgctggc ggaagcttgg gacacaacca     1380

aaaaggaaac tggaaaaatg ttccttctaa ttaccattat tgcccgtcaa gctcagattt     1440

aaattggcat aatgacttaa taggcacagc cttacaagtc aaaatgcccg cgagtcacaa     1500

ggctattcaa gcagacggtt ggatgtgtca tgcttccaaa tgggtcacta cttgtgattt     1560

ccgctggtat ggaccgaagt atataacaca ttccatccga tccttcactc catctgtaga     1620

acaatgcaag gaaagcattg aacaaacgaa acaaggaact tggctgaatc caggcttccc     1680

tcctcaaagt tgtggatatg caactgtgac ggatgccgaa gcagtgattg tccaggtgac     1740

tcctcaccat gtgctggttg atgaatacac aggagaatgg gttgattcac agttcatcaa     1800

cggaaaatgc agcaattaca tatgccccac tgtccataac tctacaacct ggcattctga     1860

ctataaggtc aaagggctat gtgattctaa cctcatttcc atggacatca ccttcttctc     1920

agaggacgga gagctatcat ccctgggaaa ggagggcaca gggttcagaa gtaactactt     1980

tgcttatgaa actggaggca aggcctgcaa aatgcaatac tgcaagcatt ggggagtcag     2040

actcccatca ggtgtctggt tcgagatggc tgataaggat ctctttgctg cagccagatt     2100

ccctgaatgc ccagaagggt caagtatctc tgctccatct cagacctcag tggatgtaag     2160

tctaattcag gacgttgaga ggatcttgga ttattccctc tgccaagaaa cctggagcaa     2220

aatcagagcg ggtcttccaa tctctccagt ggatctcagc tatcttgctc ctaaaaaccc     2280

aggaaccggt cctgctttca ccataatcaa tggtacccta aaatactttg agaccagata     2340

catcagagtc gatattgctg ctccaatcct ctcaagaatg gtcggaatga tcagtggaac     2400

taccacagaa gcggaactgt gggatgactg ggcaccatat gaagacgtgg aaattggacc     2460

caatggagtt ctgaggacca gttcaggata taagtttcct ttatacatga ttggacatgg     2520

tatgttggac tccgatcttc atcttagctc aaaggctcag gtgttcgaac atcctcacat     2580

tcaagacgct gcttcgcaac ttcctgatga tgagagttta ttttttggtg atactgggct     2640

atccaaaaat ccaatcgagc ttgtagaagg ttggttcagt agttggaaaa gctctattgc     2700

ctcttttttc tttatcatag ggttaatcat tggactattc ttggttctcc gagttggtat     2760

ccatctttgc attaaattaa agcacaccaa gaaaagacag atttatacag acatagagat     2820

gaaccgactt ggaaaggaat tcggatccgg cgcaacaaac ttctctctgc tgaaacaagc     2880

cggagatgtc gaagagaatc ctggaccgat ggtgtccaag ggcgaggaag ataacatggc     2940

catcatcaag gagttcatga ggtttaaggt ccacatggag ggttcagtca atggccacga     3000

gttcgagatt gaaggcgagg gcgagggccg cccctacgaa gggacacaga cggcgaaatt     3060

gaaggtgacc aaaggcgggc cattgccctt cgcatgggac atcttgtccc ctcagtttat     3120

gtatggcagc aaggcctatg ttaagcaccc cgctgatatc ccggactact tgaagctgtc     3180

ctttccagag gggtttaaat gggagcgcgt tatgaatttc gaagacggag gagtggttac     3240

ggtgacgcag gactcatccc tgcaggacgg agaatttata tataaggtta agttgagagg     3300

cacaaacttc ccaagcgacg gccctgtgat gcagaagaaa acaatggggt gggaagcttc     3360

cagcgagcgc atgtaccccg aagatggcgc cctcaagggc gagataaagc aaaggctgaa     3420

acttaaggac ggcggtcatt acgacgcgga ggtcaagaca acttacaagg ctaaaaaacc     3480

cgttcagttg cctggggctt acaatgttaa tatcaaactt gacatcacaa gccacaatga     3540

agactatacg atcgtggagc agtatgaacg agcggaaggc aggcactcaa cgggggggat     3600

ggacgagctt tacaag                                                     3616


<210>  27
<211>  1237
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  27
acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc       60

atattggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac      120

gacccccgcc ccttgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact      180

ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa      240

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg      300

cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta      360

gtcatcgcta ttaccatggt gatgcggttg tggcagtaca tcaatgggcg tggatagcgg      420

tttgactcac ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg      480

caccaaaatc aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg      540

ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ctcgtttagt gaaccgtcag      600

atcgcctgga gacgccatcc acgctgtttt gacctccata gaagacaccg ggaccgatcc      660

agcctcccct cgaagcttta catgtggtac cgagctcgga tcctgagaac ttcagggtga      720

gtctatggga cccttgatgt tttctttccc cttcttttct atggttaagt tcatgtcata      780

ggaaggggag aagtaacagg gtacacatat tgaccaaatc agggtaattt tgcatttgta      840

attttaaaaa atgctttctt cttttaatat acttttttgt ttatcttatt tctaatactt      900

tccctaatct ctttctttca gggcaataat gatacaatgt atcatgcctc tttgcaccat      960

tctaaagaat aacagtgata atttctgggt taaggcaata gcaatatttc tgcatataaa     1020

tatttctgca tataaattgt aactgatgta agaggtttca tattgctaat agcagctaca     1080

atccagctac cattctgctt ttattttatg gttgggataa ggctggatta ttctgagtcc     1140

aagctaggcc cttttgctaa tcatgttcat acctcttatc ttcctcccac agctcctggg     1200

caacgtgctg gtctgtgtgc tggcccatca ctttggc                              1237


<210>  28
<211>  495
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  28

Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
1               5                   10                  15      


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
            20                  25                  30          


His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Ala Ser 
        35                  40                  45              


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
    50                  55                  60                  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
65                  70                  75                  80  


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
                85                  90                  95      


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
            100                 105                 110         


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
        115                 120                 125             


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
    130                 135                 140                 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr 
145                 150                 155                 160 


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
                165                 170                 175     


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
            180                 185                 190         


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
        195                 200                 205             


Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys 
    210                 215                 220                 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
225                 230                 235                 240 


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
                245                 250                 255     


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
            260                 265                 270         


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
        275                 280                 285             


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
    290                 295                 300                 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
305                 310                 315                 320 


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
                325                 330                 335     


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
            340                 345                 350         


Glu Ala Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
        355                 360                 365             


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
    370                 375                 380                 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
385                 390                 395                 400 


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
                405                 410                 415     


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
            420                 425                 430         


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
        435                 440                 445             


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
    450                 455                 460                 


Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys 
465                 470                 475                 480 


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
                485                 490                 495 


