                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
 
<120>  NOVEL AAV CAPSIDS AND COMPOSITIONS CONTAINING SAME

<130>  19-8901PCT1

<150>  US 62/924,095
<151>  2019-10-21

<150>  US 62/913,314
<151>  2019-10-10

<150>  US 62/840,184
<151>  2019-04-29

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  2217
<212>  DNA
<213>  adeno-associated virus rh.90


<220>
<221>  CDS
<222>  (1)..(2217)

<400>  1
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctc tct         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gag ggc att cgc gag tgg tgg gac ctg aaa cct gga gcc cca aaa ccc         96
Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro           
            20                  25                  30                    

aaa gcc aac cag caa aag cag gac gac ggc cgg ggt ctg gtg ctt cct        144
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggc tac aag tac ctc gga ccc ttc aac gga ctc gac aag ggg gag ccc        192
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gcg gcg gac gca gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctg cag gcg ggt gat aat ccg tac ctg cgg tat aac cac gcc        288
Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttt cag gag cgt ctg caa gaa gat acg tca ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aag aag cgg gtt ctc gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro           
        115                 120                 125                       

ctc ggt ctg gtt gag gaa ggc gct aag acg gct cct gga aag aag aga        432
Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

ccg gta gag cca tca cca cag cgt tcc ccc gac tcc tcc acg ggc atc        480
Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile           
145                 150                 155                 160           

ggc aag aaa ggc cag cag ccc gcc aga aag aga ctc aat ttc ggt cag        528
Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln           
                165                 170                 175               

act ggc gac tca gag tca gtc ccc gac cct caa cct ctc gga gaa cct        576
Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro           
            180                 185                 190                   

cca gca gcg ccc tct agt gtg gga tct ggt aca atg gct gca ggc ggt        624
Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly           
        195                 200                 205                       

ggc gca cca atg gca gac aat aac gaa ggt gcc gac gga gtg ggt agt        672
Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser           
    210                 215                 220                           

tcc tcg gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac aga gtc        720
Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val           
225                 230                 235                 240           

atc acc acc agc acc cga acc tgg gcc ctg ccc acc tac aac aac cac        768
Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His           
                245                 250                 255               

ctc tac aag caa atc tcc aac ggg acc tcg gga ggc agc acc aac gac        816
Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp           
            260                 265                 270                   

aac acc tac ttc ggc tac agc acc ccc tgg ggg tat ttt gac ttt aac        864
Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn           
        275                 280                 285                       

aga ttc cac tgc cac ttc tca cca cgt gac tgg cag cga ctt atc aac        912
Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn           
    290                 295                 300                           

aac aac tgg gga ttc cgg ccc aag aga ctc agc ttc aag ctc ttc aac        960
Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn           
305                 310                 315                 320           

atc cag gtc aag gag gtc acg caa aat gaa ggc acc aag acc atc gcc       1008
Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala           
                325                 330                 335               

aat aac ctc acc agc acc atc cag gtg ttt acg gac tcg gaa tac cag       1056
Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln           
            340                 345                 350                   

ctg cca tac gtc ctc ggc tct gcc cac cag ggc tgc ctg cct ccg ttc       1104
Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe           
        355                 360                 365                       

ccg gcg gac gtc ttc atg att cct cag tat ggc tac ctg acg ctg aac       1152
Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn           
    370                 375                 380                           

aac gga agt cag gcc gtg ggc cgt tcc tcc ttc tac tgc ctg gag tac       1200
Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr           
385                 390                 395                 400           

ttt ccc tct cag atg cta aga acg ggc aac aac ttc tcc ttc agc tat       1248
Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr           
                405                 410                 415               

acc ttc gag gac gtg cct ttc cac agc agc tac gcg cac agc cag agc       1296
Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser           
            420                 425                 430                   

ctg gac cgg ctg atg aat ccc ctc att gac cag tac ctg tac tac ctg       1344
Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu           
        435                 440                 445                       

tcg cgg aca caa tcc aca gga ggc aca gcg gga act cag cag ttg ctg       1392
Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu           
    450                 455                 460                           

ttt tct cag gcc ggg cct aac aac atg tct gct cag gcc aaa aac tgg       1440
Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp           
465                 470                 475                 480           

cta ccc gga cct tgt tat cgg cag caa cgt gtt tcc acg aca ctg tcg       1488
Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser           
                485                 490                 495               

caa aac aac aac agc aac ttt gcc tgg acc ggt gcc acc aaa tac cac       1536
Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His           
            500                 505                 510                   

ctg aac gga aga gac tct ctg gta aat ccg ggt gtc gcc atg gca acc       1584
Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr           
        515                 520                 525                       

aac aag gac gac gag gac cgc ttc ttc cca tcc agc ggc atc ctc atg       1632
Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met           
    530                 535                 540                           

ttt ggc aag cag ggg gct gga aaa gac aac gtg gac tat agc aac gtg       1680
Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val           
545                 550                 555                 560           

atg cta acc agc gag gaa gaa atc aag acc act aac cct gtg gcc aca       1728
Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr           
                565                 570                 575               

gaa cag tat ggt gtg gtg gcg gat aac ctg cag cag caa aac aca gct       1776
Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala           
            580                 585                 590                   

cct att gtg ggg gcc gtc aac agc caa gga gcc tta cct ggc atg gtt       1824
Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val           
        595                 600                 605                       

tgg cag aac cgg gac gtg tac ctg cag ggt ccc atc tgg gcc aag att       1872
Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile           
    610                 615                 620                           

cct cac acg gat ggt aac ttt cac ccg tct cct ctc atg ggc ggc ttt       1920
Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe           
625                 630                 635                 640           

gga ctt aaa cat ccg cct cct cag atc ctg atc aag aac act ccc gtt       1968
Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val           
                645                 650                 655               

cct gcg gat cct cca acg gcg ttc aac cag gcc aag ctg aac tct ttc       2016
Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe           
            660                 665                 670                   

atc acg cag tac agc acc gga caa gtc agc gtg gag atc gag tgg gag       2064
Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu           
        675                 680                 685                       

ctg cag aag gag aac agc aag cgc tgg aac cca gag att cag tat acc       2112
Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr           
    690                 695                 700                           

tcc aac tac tac aaa tct aca aat gtg gac ttt gct gtt aat act gag       2160
Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu           
705                 710                 715                 720           

ggt gtt tac tct gag cct cgc ccc att ggc acc cgt tac ctc acc cgt       2208
Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg           
                725                 730                 735               

aat ctg taa                                                           2217
Asn Leu                                                                   
                                                                          


<210>  2
<211>  738
<212>  PRT
<213>  adeno-associated virus rh.90

<400>  2

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  3
<211>  2217
<212>  DNA
<213>  adeno-associated virus 8


<220>
<221>  CDS
<222>  (1)..(2217)

<400>  3
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctc tct         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gag ggc att cgc gag tgg tgg gcg ctg aaa cct gga gcc ccg aag ccc         96
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro           
            20                  25                  30                    

aaa gcc aac cag caa aag cag gac gac ggc cgg ggt ctg gtg ctt cct        144
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggc tac aag tac ctc gga ccc ttc aac gga ctc gac aag ggg gag ccc        192
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gcg gcg gac gca gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctg cag gcg ggt gac aat ccg tac ctg cgg tat aac cac gcc        288
Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttt cag gag cgt ctg caa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aag aag cgg gtt ctc gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro           
        115                 120                 125                       

ctc ggt ctg gtt gag gaa ggc gct aag acg gct cct gga aag aag aga        432
Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

ccg gta gag cca tca ccc cag cgt tct cca gac tcc tct acg ggc atc        480
Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile           
145                 150                 155                 160           

ggc aag aaa ggc caa cag ccc gcc aga aaa aga ctc aat ttt ggt cag        528
Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln           
                165                 170                 175               

act ggc gac tca gag tca gtt cca gac cct caa cct ctc gga gaa cct        576
Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro           
            180                 185                 190                   

cca gca gcg ccc tct ggt gtg gga cct aat aca atg gct gca ggc ggt        624
Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly           
        195                 200                 205                       

ggc gca cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt agt        672
Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser           
    210                 215                 220                           

tcc tcg gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac aga gtc        720
Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val           
225                 230                 235                 240           

atc acc acc agc acc cga acc tgg gcc ctg ccc acc tac aac aac cac        768
Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His           
                245                 250                 255               

ctc tac aag caa atc tcc aac ggg aca tcg gga gga gcc acc aac gac        816
Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp           
            260                 265                 270                   

aac acc tac ttc ggc tac agc acc ccc tgg ggg tat ttt gac ttt aac        864
Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn           
        275                 280                 285                       

aga ttc cac tgc cac ttt tca cca cgt gac tgg cag cga ctc atc aac        912
Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn           
    290                 295                 300                           

aac aac tgg gga ttc cgg ccc aag aga ctc agc ttc aag ctc ttc aac        960
Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn           
305                 310                 315                 320           

atc cag gtc aag gag gtc acg cag aat gaa ggc acc aag acc atc gcc       1008
Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala           
                325                 330                 335               

aat aac ctc acc agc acc atc cag gtg ttt acg gac tcg gag tac cag       1056
Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln           
            340                 345                 350                   

ctg ccg tac gtt ctc ggc tct gcc cac cag ggc tgc ctg cct ccg ttc       1104
Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe           
        355                 360                 365                       

ccg gcg gac gtg ttc atg att ccc cag tac ggc tac cta aca ctc aac       1152
Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn           
    370                 375                 380                           

aac ggt agt cag gcc gtg gga cgc tcc tcc ttc tac tgc ctg gaa tac       1200
Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr           
385                 390                 395                 400           

ttt cct tcg cag atg ctg aga acc ggc aac aac ttc cag ttt act tac       1248
Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr           
                405                 410                 415               

acc ttc gag gac gtg cct ttc cac agc agc tac gcc cac agc cag agc       1296
Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser           
            420                 425                 430                   

ttg gac cgg ctg atg aat cct ctg att gac cag tac ctg tac tac ttg       1344
Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu           
        435                 440                 445                       

tct cgg act caa aca aca gga ggc acg gca aat acg cag act ctg ggc       1392
Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly           
    450                 455                 460                           

ttc agc caa ggt ggg cct aat aca atg gcc aat cag gca aag aac tgg       1440
Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp           
465                 470                 475                 480           

ctg cca gga ccc tgt tac cgc caa caa cgc gtc tca acg aca acc ggg       1488
Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly           
                485                 490                 495               

caa aac aac aat agc aac ttt gcc tgg act gct ggg acc aaa tac cat       1536
Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His           
            500                 505                 510                   

ctg aat gga aga aat tca ttg gct aat cct ggc atc gct atg gca aca       1584
Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr           
        515                 520                 525                       

cac aaa gac gac gag gag cgt ttt ttt ccc agt aac ggg atc ctg att       1632
His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile           
    530                 535                 540                           

ttt ggc aaa caa aat gct gcc aga gac aat gcg gat tac agc gat gtc       1680
Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val           
545                 550                 555                 560           

atg ctc acc agc gag gaa gaa atc aaa acc act aac cct gtg gct aca       1728
Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr           
                565                 570                 575               

gag gaa tac ggt atc gtg gca gat aac ttg cag cag caa aac acg gct       1776
Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala           
            580                 585                 590                   

cct caa att gga act gtc aac agc cag ggg gcc tta ccc ggt atg gtc       1824
Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val           
        595                 600                 605                       

tgg cag aac cgg gac gtg tac ctg cag ggt ccc atc tgg gcc aag att       1872
Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile           
    610                 615                 620                           

cct cac acg gac ggc aac ttc cac ccg tct ccg ctg atg ggc ggc ttt       1920
Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe           
625                 630                 635                 640           

ggc ctg aaa cat cct ccg cct cag atc ctg atc aag aac acg cct gta       1968
Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val           
                645                 650                 655               

cct gcg gat cct ccg acc acc ttc aac cag tca aag ctg aac tct ttc       2016
Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe           
            660                 665                 670                   

atc acg caa tac agc acc gga cag gtc agc gtg gaa att gaa tgg gag       2064
Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu           
        675                 680                 685                       

ctg cag aag gaa aac agc aag cgc tgg aac ccc gag atc cag tac acc       2112
Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr           
    690                 695                 700                           

tcc aac tac tac aaa tct aca agt gtg gac ttt gct gtt aat aca gaa       2160
Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu           
705                 710                 715                 720           

ggc gtg tac tct gaa ccc cgc ccc att ggc acc cgt tac ctc acc cgt       2208
Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg           
                725                 730                 735               

aat ctg taa                                                           2217
Asn Leu                                                                   
                                                                          


<210>  4
<211>  738
<212>  PRT
<213>  adeno-associated virus 8

<400>  4

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  5
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  5
gctgcgtcaa ctggaccaat gagaac                                            26


<210>  6
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  6
cgcagagacc aaagttcaac tgaaacga                                          28


<210>  7
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  7
ggcgaacagc ggacaccgat atgaa                                             25


<210>  8
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  8
ggctctcgtc gcgtgagaat gagaa                                             25


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miRNA target sequence

<400>  9
agtgaattct accagtgcca ta                                                22


<210>  10
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miRNA target sequence

<400>  10
agtgtgagtt ctaccattgc caaa                                              24


