                         SEQUENCE LISTING

<110>  OCUGEN, INC.
 
<120>  ADENO-ASSOCIATED VIRUS VECTOR MEDIATED GENE THERAPY FOR 
       OPHTHALMIC DISEASES

<130>  OCU-000600PC

<150>  62/839,672
<151>  2019-04-27

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  1233
<212>  DNA
<213>  Homo sapiens

<400>  1
atggagacca gaccaacagc tctgatgagc tccacagtgg ctgcagctgc gcctgcagct       60

ggggctgcct ccaggaagga gtctccaggc agatggggcc tgggggagga tcccacaggc      120

gtgagcccct cgctccagtg ccgcgtgtgc ggagacagca gcagcgggaa gcactatggc      180

atctatgcct gcaacggctg cagcggcttc ttcaagagga gcgtacggcg gaggctcatc      240

tacaggtgcc aggtgggggc agggatgtgc cccgtggaca aggcccaccg caaccagtgc      300

caggcctgcc ggctgaagaa gtgcctgcag gcggggatga accaggacgc cgtgcagaac      360

gagcgccagc cgcgaagcac agcccaggtc cacctggaca gcatggagtc caacactgag      420

tcccggccgg agtccctggt ggctcccccg gccccggcag ggcgcagccc acggggcccc      480

acacccatgt ctgcagccag agccctgggc caccacttca tggccagcct tataacagct      540

gaaacctgtg ctaagctgga gccagaggat gctgatgaga atattgatgt caccagcaat      600

gaccctgagt tcccctcctc tccatactcc tcttcctccc cctgcggcct ggacagcatc      660

catgagacct cggctcgcct actcttcatg gccgtcaagt gggccaagaa cctgcctgtg      720

ttctccagcc tgcccttccg ggatcaggtg atcctgctgg aagaggcgtg gagtgaactc      780

tttctcctcg gggccatcca gtggtctctg cctctggaca gctgtcctct gctggcaccg      840

cccgaggcct ctgctgccgg tggtgcccag ggccggctca cgctggccag catggagacg      900

cgtgtcctgc aggaaactat ctctcggttc cgggcattgg cggtggaccc cacggagttt      960

gcctgcatga aggccttggt cctcttcaag ccagagacgc ggggcctgaa ggatcctgag     1020

cacgtagagg ccttgcagga ccagtcccaa gtgatgctga gccagcacag caaggcccac     1080

caccccagcc agcccgtgag gtttgggaaa ttgctcctgc tcctcccgtc tttgaggttt     1140

atcactgcgg aacgcatcga gctcctcttt ttccgcaaga ccatagggaa tactccaatg     1200

gagaagctcc tttgtgatat gttcaaaaac tag                                  1233


<210>  2
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Thr Arg Pro Thr Ala Leu Met Ser Ser Thr Val Ala Ala Ala 
1               5                   10                  15      


Ala Pro Ala Ala Gly Ala Ala Ser Arg Lys Glu Ser Pro Gly Arg Trp 
            20                  25                  30          


Gly Leu Gly Glu Asp Pro Thr Gly Val Ser Pro Ser Leu Gln Cys Arg 
        35                  40                  45              


Val Cys Gly Asp Ser Ser Ser Gly Lys His Tyr Gly Ile Tyr Ala Cys 
    50                  55                  60                  


Asn Gly Cys Ser Gly Phe Phe Lys Arg Ser Val Arg Arg Arg Leu Ile 
65                  70                  75                  80  


Tyr Arg Cys Gln Val Gly Ala Gly Met Cys Pro Val Asp Lys Ala His 
                85                  90                  95      


Arg Asn Gln Cys Gln Ala Cys Arg Leu Lys Lys Cys Leu Gln Ala Gly 
            100                 105                 110         


Met Asn Gln Asp Ala Val Gln Asn Glu Arg Gln Pro Arg Ser Thr Ala 
        115                 120                 125             


Gln Val His Leu Asp Ser Met Glu Ser Asn Thr Glu Ser Arg Pro Glu 
    130                 135                 140                 


Ser Leu Val Ala Pro Pro Ala Pro Ala Gly Arg Ser Pro Arg Gly Pro 
145                 150                 155                 160 


Thr Pro Met Ser Ala Ala Arg Ala Leu Gly His His Phe Met Ala Ser 
                165                 170                 175     


Leu Ile Thr Ala Glu Thr Cys Ala Lys Leu Glu Pro Glu Asp Ala Asp 
            180                 185                 190         


Glu Asn Ile Asp Val Thr Ser Asn Asp Pro Glu Phe Pro Ser Ser Pro 
        195                 200                 205             


Tyr Ser Ser Ser Ser Pro Cys Gly Leu Asp Ser Ile His Glu Thr Ser 
    210                 215                 220                 


Ala Arg Leu Leu Phe Met Ala Val Lys Trp Ala Lys Asn Leu Pro Val 
225                 230                 235                 240 


Phe Ser Ser Leu Pro Phe Arg Asp Gln Val Ile Leu Leu Glu Glu Ala 
                245                 250                 255     


Trp Ser Glu Leu Phe Leu Leu Gly Ala Ile Gln Trp Ser Leu Pro Leu 
            260                 265                 270         


Asp Ser Cys Pro Leu Leu Ala Pro Pro Glu Ala Ser Ala Ala Gly Gly 
        275                 280                 285             


Ala Gln Gly Arg Leu Thr Leu Ala Ser Met Glu Thr Arg Val Leu Gln 
    290                 295                 300                 


Glu Thr Ile Ser Arg Phe Arg Ala Leu Ala Val Asp Pro Thr Glu Phe 
305                 310                 315                 320 


Ala Cys Met Lys Ala Leu Val Leu Phe Lys Pro Glu Thr Arg Gly Leu 
                325                 330                 335     


Lys Asp Pro Glu His Val Glu Ala Leu Gln Asp Gln Ser Gln Val Met 
            340                 345                 350         


Leu Ser Gln His Ser Lys Ala His His Pro Ser Gln Pro Val Arg Phe 
        355                 360                 365             


Gly Lys Leu Leu Leu Leu Leu Pro Ser Leu Arg Phe Ile Thr Ala Glu 
    370                 375                 380                 


Arg Ile Glu Leu Leu Phe Phe Arg Lys Thr Ile Gly Asn Thr Pro Met 
385                 390                 395                 400 


Glu Lys Leu Leu Cys Asp Met Phe Lys Asn 
                405                 410 


<210>  3
<211>  1518
<212>  DNA
<213>  Homo sapiens

<400>  3
atgggtgaaa ctctgggaga ttctcctatt gacccagaaa gcgattcctt cactgataca       60

ctgtctgcaa acatatcaca agaaatgacc atggttgaca cagagatgcc attctggccc      120

accaactttg ggatcagctc cgtggatctc tccgtaatgg aagaccactc ccactccttt      180

gatatcaagc ccttcactac tgttgacttc tccagcattt ctactccaca ttacgaagac      240

attccattca caagaacaga tccagtggtt gcagattaca agtatgacct gaaacttcaa      300

gagtaccaaa gtgcaatcaa agtggagcct gcatctccac cttattattc tgagaagact      360

cagctctaca ataagcctca tgaagagcct tccaactccc tcatggcaat tgaatgtcgt      420

gtctgtggag ataaagcttc tggatttcac tatggagttc atgcttgtga aggatgcaag      480

ggtttcttcc ggagaacaat cagattgaag cttatctatg acagatgtga tcttaactgt      540

cggatccaca aaaaaagtag aaataaatgt cagtactgtc ggtttcagaa atgccttgca      600

gtggggatgt ctcataatgc catcaggttt gggcggatgc cacaggccga gaaggagaag      660

ctgttggcgg agatctccag tgatatcgac cagctgaatc cagagtccgc tgacctccgg      720

gccctggcaa aacatttgta tgactcatac ataaagtcct tcccgctgac caaagcaaag      780

gcgagggcga tcttgacagg aaagacaaca gacaaatcac cattcgttat ctatgacatg      840

aattccttaa tgatgggaga agataaaatc aagttcaaac acatcacccc cctgcaggag      900

cagagcaaag aggtggccat ccgcatcttt cagggctgcc agtttcgctc cgtggaggct      960

gtgcaggaga tcacagagta tgccaaaagc attcctggtt ttgtaaatct tgacttgaac     1020

gaccaagtaa ctctcctcaa atatggagtc cacgagatca tttacacaat gctggcctcc     1080

ttgatgaata aagatggggt tctcatatcc gagggccaag gcttcatgac aagggagttt     1140

ctaaagagcc tgcgaaagcc ttttggtgac tttatggagc ccaagtttga gtttgctgtg     1200

aagttcaatg cactggaatt agatgacagc gacttggcaa tatttattgc tgtcattatt     1260

ctcagtggag accgcccagg tttgctgaat gtgaagccca ttgaagacat tcaagacaac     1320

ctgctacaag ccctggagct ccagctgaag ctgaaccacc ctgagtcctc acagctgttt     1380

gccaagctgc tccagaaaat gacagacctc agacagattg tcacggaaca cgtgcagcta     1440

ctgcaggtga tcaagaagac ggagacagac atgagtcttc acccgctcct gcaggagatc     1500

tacaaggact tgtactag                                                   1518


<210>  4
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Glu Thr Leu Gly Asp Ser Pro Ile Asp Pro Glu Ser Asp Ser 
1               5                   10                  15      


Phe Thr Asp Thr Leu Ser Ala Asn Ile Ser Gln Glu Met Thr Met Val 
            20                  25                  30          


Asp Thr Glu Met Pro Phe Trp Pro Thr Asn Phe Gly Ile Ser Ser Val 
        35                  40                  45              


Asp Leu Ser Val Met Glu Asp His Ser His Ser Phe Asp Ile Lys Pro 
    50                  55                  60                  


Phe Thr Thr Val Asp Phe Ser Ser Ile Ser Thr Pro His Tyr Glu Asp 
65                  70                  75                  80  


Ile Pro Phe Thr Arg Thr Asp Pro Val Val Ala Asp Tyr Lys Tyr Asp 
                85                  90                  95      


Leu Lys Leu Gln Glu Tyr Gln Ser Ala Ile Lys Val Glu Pro Ala Ser 
            100                 105                 110         


Pro Pro Tyr Tyr Ser Glu Lys Thr Gln Leu Tyr Asn Lys Pro His Glu 
        115                 120                 125             


Glu Pro Ser Asn Ser Leu Met Ala Ile Glu Cys Arg Val Cys Gly Asp 
    130                 135                 140                 


Lys Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys 
145                 150                 155                 160 


Gly Phe Phe Arg Arg Thr Ile Arg Leu Lys Leu Ile Tyr Asp Arg Cys 
                165                 170                 175     


Asp Leu Asn Cys Arg Ile His Lys Lys Ser Arg Asn Lys Cys Gln Tyr 
            180                 185                 190         


Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Ser His Asn Ala Ile 
        195                 200                 205             


Arg Phe Gly Arg Met Pro Gln Ala Glu Lys Glu Lys Leu Leu Ala Glu 
    210                 215                 220                 


Ile Ser Ser Asp Ile Asp Gln Leu Asn Pro Glu Ser Ala Asp Leu Arg 
225                 230                 235                 240 


Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr Ile Lys Ser Phe Pro Leu 
                245                 250                 255     


Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr Gly Lys Thr Thr Asp Lys 
            260                 265                 270         


Ser Pro Phe Val Ile Tyr Asp Met Asn Ser Leu Met Met Gly Glu Asp 
        275                 280                 285             


Lys Ile Lys Phe Lys His Ile Thr Pro Leu Gln Glu Gln Ser Lys Glu 
    290                 295                 300                 


Val Ala Ile Arg Ile Phe Gln Gly Cys Gln Phe Arg Ser Val Glu Ala 
305                 310                 315                 320 


Val Gln Glu Ile Thr Glu Tyr Ala Lys Ser Ile Pro Gly Phe Val Asn 
                325                 330                 335     


Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val His Glu 
            340                 345                 350         


Ile Ile Tyr Thr Met Leu Ala Ser Leu Met Asn Lys Asp Gly Val Leu 
        355                 360                 365             


Ile Ser Glu Gly Gln Gly Phe Met Thr Arg Glu Phe Leu Lys Ser Leu 
    370                 375                 380                 


Arg Lys Pro Phe Gly Asp Phe Met Glu Pro Lys Phe Glu Phe Ala Val 
385                 390                 395                 400 


Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Ile Phe Ile 
                405                 410                 415     


Ala Val Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu Leu Asn Val Lys 
            420                 425                 430         


Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala Leu Glu Leu Gln 
        435                 440                 445             


Leu Lys Leu Asn His Pro Glu Ser Ser Gln Leu Phe Ala Lys Leu Leu 
    450                 455                 460                 


Gln Lys Met Thr Asp Leu Arg Gln Ile Val Thr Glu His Val Gln Leu 
465                 470                 475                 480 


Leu Gln Val Ile Lys Lys Thr Glu Thr Asp Met Ser Leu His Pro Leu 
                485                 490                 495     


Leu Gln Glu Ile Tyr Lys Asp Leu Tyr 
            500                 505 


<210>  5
<211>  1845
<212>  DNA
<213>  Homo sapiens

<400>  5
atgacgaccc tggactccaa caacaacaca ggtggcgtca tcacctacat tggctccagt       60

ggctcctccc caagccgcac cagccctgaa tccctctata gtgacaactc caatggcagc      120

ttccagtccc tgacccaagg ctgtcccacc tacttcccac catcccccac tggctccctc      180

acccaagacc cggctcgctc ctttgggagc attccaccca gcctgagtga tgacggctcc      240

ccttcttcct catcttcctc gtcgtcatcc tcctcctcct tctataatgg gagcccccct      300

gggagtctac aagtggccat ggaggacagc agccgagtgt cccccagcaa gagcaccagc      360

aacatcacca agctgaatgg catggtgtta ctgtgtaaag tgtgtgggga cgttgcctcg      420

ggcttccact acggtgtgca cgcctgcgag ggctgcaagg gctttttccg tcggagcatc      480

cagcagaaca tccagtacaa aaggtgtctg aagaatgaga attgctccat cgtccgcatc      540

aatcgcaacc gctgccagca atgtcgcttc aagaagtgtc tctctgtggg catgtctcga      600

gacgctgtgc gttttgggcg catccccaaa cgagagaagc agcggatgct tgctgagatg      660

cagagtgcca tgaacctggc caacaaccag ttgagcagcc agtgcccgct ggagacttca      720

cccacccagc accccacccc aggccccatg ggcccctcgc caccccctgc tccggtcccc      780

tcacccctgg tgggcttctc ccagtttcca caacagctga cgcctcccag atccccaagc      840

cctgagccca cagtggagga tgtgatatcc caggtggccc gggcccatcg agagatcttc      900

acctacgccc atgacaagct gggcagctca cctggcaact tcaatgccaa ccatgcatca      960

ggtagccctc cagccaccac cccacatcgc tgggaaaatc agggctgccc acctgccccc     1020

aatgacaaca acaccttggc tgcccagcgt cataacgagg ccctaaatgg tctgcgccag     1080

gctccctcct cctaccctcc cacctggcct cctggccctg cacaccacag ctgccaccag     1140

tccaacagca acgggcaccg tctatgcccc acccacgtgt atgcagcccc agaaggcaag     1200

gcacctgcca acagtccccg gcagggcaac tcaaagaatg ttctgctggc atgtcctatg     1260

aacatgtacc cgcatggacg cagtgggcga acggtgcagg agatctggga ggatttctcc     1320

atgagcttca cgcccgctgt gcgggaggtg gtagagtttg ccaaacacat cccgggcttc     1380

cgtgaccttt ctcagcatga ccaagtcacc ctgcttaagg ctggcacctt tgaggtgctg     1440

atggtgcgct ttgcttcgtt gttcaacgtg aaggaccaga cagtgatgtt cctaagccgc     1500

accacctaca gcctgcagga gcttggtgcc atgggcatgg gagacctgct cagtgccatg     1560

ttcgacttca gcgagaagct caactccctg gcgcttaccg aggaggagct gggcctcttc     1620

accgcggtgg tgcttgtctc tgcagaccgc tcgggcatgg agaattccgc ttcggtggag     1680

cagctccagg agacgctgct gcgggctctt cgggctctgg tgctgaagaa ccggcccttg     1740

gagacttccc gcttcaccaa gctgctgctc aagctgccgg acctgcggac cctgaacaac     1800

atgcattccg agaagctgct gtccttccgg gtggacgccc agtga                     1845


<210>  6
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Thr Leu Asp Ser Asn Asn Asn Thr Gly Gly Val Ile Thr Tyr 
1               5                   10                  15      


Ile Gly Ser Ser Gly Ser Ser Pro Ser Arg Thr Ser Pro Glu Ser Leu 
            20                  25                  30          


Tyr Ser Asp Asn Ser Asn Gly Ser Phe Gln Ser Leu Thr Gln Gly Cys 
        35                  40                  45              


Pro Thr Tyr Phe Pro Pro Ser Pro Thr Gly Ser Leu Thr Gln Asp Pro 
    50                  55                  60                  


Ala Arg Ser Phe Gly Ser Ile Pro Pro Ser Leu Ser Asp Asp Gly Ser 
65                  70                  75                  80  


Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Phe Tyr Asn 
                85                  90                  95      


Gly Ser Pro Pro Gly Ser Leu Gln Val Ala Met Glu Asp Ser Ser Arg 
            100                 105                 110         


Val Ser Pro Ser Lys Ser Thr Ser Asn Ile Thr Lys Leu Asn Gly Met 
        115                 120                 125             


Val Leu Leu Cys Lys Val Cys Gly Asp Val Ala Ser Gly Phe His Tyr 
    130                 135                 140                 


Gly Val His Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Ile 
145                 150                 155                 160 


Gln Gln Asn Ile Gln Tyr Lys Arg Cys Leu Lys Asn Glu Asn Cys Ser 
                165                 170                 175     


Ile Val Arg Ile Asn Arg Asn Arg Cys Gln Gln Cys Arg Phe Lys Lys 
            180                 185                 190         


Cys Leu Ser Val Gly Met Ser Arg Asp Ala Val Arg Phe Gly Arg Ile 
        195                 200                 205             


Pro Lys Arg Glu Lys Gln Arg Met Leu Ala Glu Met Gln Ser Ala Met 
    210                 215                 220                 


Asn Leu Ala Asn Asn Gln Leu Ser Ser Gln Cys Pro Leu Glu Thr Ser 
225                 230                 235                 240 


Pro Thr Gln His Pro Thr Pro Gly Pro Met Gly Pro Ser Pro Pro Pro 
                245                 250                 255     


Ala Pro Val Pro Ser Pro Leu Val Gly Phe Ser Gln Phe Pro Gln Gln 
            260                 265                 270         


Leu Thr Pro Pro Arg Ser Pro Ser Pro Glu Pro Thr Val Glu Asp Val 
        275                 280                 285             


Ile Ser Gln Val Ala Arg Ala His Arg Glu Ile Phe Thr Tyr Ala His 
    290                 295                 300                 


Asp Lys Leu Gly Ser Ser Pro Gly Asn Phe Asn Ala Asn His Ala Ser 
305                 310                 315                 320 


Gly Ser Pro Pro Ala Thr Thr Pro His Arg Trp Glu Asn Gln Gly Cys 
                325                 330                 335     


Pro Pro Ala Pro Asn Asp Asn Asn Thr Leu Ala Ala Gln Arg His Asn 
            340                 345                 350         


Glu Ala Leu Asn Gly Leu Arg Gln Ala Pro Ser Ser Tyr Pro Pro Thr 
        355                 360                 365             


Trp Pro Pro Gly Pro Ala His His Ser Cys His Gln Ser Asn Ser Asn 
    370                 375                 380                 


Gly His Arg Leu Cys Pro Thr His Val Tyr Ala Ala Pro Glu Gly Lys 
385                 390                 395                 400 


Ala Pro Ala Asn Ser Pro Arg Gln Gly Asn Ser Lys Asn Val Leu Leu 
                405                 410                 415     


Ala Cys Pro Met Asn Met Tyr Pro His Gly Arg Ser Gly Arg Thr Val 
            420                 425                 430         


Gln Glu Ile Trp Glu Asp Phe Ser Met Ser Phe Thr Pro Ala Val Arg 
        435                 440                 445             


Glu Val Val Glu Phe Ala Lys His Ile Pro Gly Phe Arg Asp Leu Ser 
    450                 455                 460                 


Gln His Asp Gln Val Thr Leu Leu Lys Ala Gly Thr Phe Glu Val Leu 
465                 470                 475                 480 


Met Val Arg Phe Ala Ser Leu Phe Asn Val Lys Asp Gln Thr Val Met 
                485                 490                 495     


Phe Leu Ser Arg Thr Thr Tyr Ser Leu Gln Glu Leu Gly Ala Met Gly 
            500                 505                 510         


Met Gly Asp Leu Leu Ser Ala Met Phe Asp Phe Ser Glu Lys Leu Asn 
        515                 520                 525             


Ser Leu Ala Leu Thr Glu Glu Glu Leu Gly Leu Phe Thr Ala Val Val 
    530                 535                 540                 


Leu Val Ser Ala Asp Arg Ser Gly Met Glu Asn Ser Ala Ser Val Glu 
545                 550                 555                 560 


Gln Leu Gln Glu Thr Leu Leu Arg Ala Leu Arg Ala Leu Val Leu Lys 
                565                 570                 575     


Asn Arg Pro Leu Glu Thr Ser Arg Phe Thr Lys Leu Leu Leu Lys Leu 
            580                 585                 590         


Pro Asp Leu Arg Thr Leu Asn Asn Met His Ser Glu Lys Leu Leu Ser 
        595                 600                 605             


Phe Arg Val Asp Ala Gln 
    610                 


<210>  7
<211>  1572
<212>  DNA
<213>  Homo sapiens

<400>  7
atggagtcag ctccggcagc ccccgacccc gccgccagcg agccaggcag cagcggcgcg       60

gacgcggccg ccggctccag ggagaccccg ctgaaccagg aatccgcccg caagagcgag      120

ccgcctgccc cggtgcgcag acagagctat tccagcacca gcagaggtat ctcagtaacg      180

aagaagacac atacatctca aattgaaatt attccatgca agatctgtgg agacaaatca      240

tcaggaatcc attatggtgt cattacatgt gaaggctgca agggcttttt caggagaagt      300

cagcaaagca atgccaccta ctcctgtcct cgtcagaaga actgtttgat tgatcgaacc      360

agtagaaacc gctgccaaca ctgtcgatta cagaaatgcc ttgccgtagg gatgtctcga      420

gatgctgtaa aatttggccg aatgtcaaaa aagcagagag acagcttgta tgcagaagta      480

cagaaacacc ggatgcagca gcagcagcgc gaccaccagc agcagcctgg agaggctgag      540

ccgctgacgc ccacctacaa catctcggcc aacgggctga cggaacttca cgacgacctc      600

agtaactaca ttgacgggca cacccctgag gggagtaagg cagactccgc cgtcagcagc      660

ttctacctgg acatacagcc ttccccagac cagtcaggtc ttgatatcaa tggaatcaaa      720

ccagaaccaa tatgtgacta cacaccagca tcaggcttct ttccctactg ttcgttcacc      780

aacggcgaga cttccccaac tgtgtccatg gcagaattag aacaccttgc acagaatata      840

tctaaatcgc atctggaaac ctgccaatac ttgagagaag agctccagca gataacgtgg      900

cagacctttt tacaggaaga aattgagaac tatcaaaaca agcagcggga ggtgatgtgg      960

caattgtgtg ccatcaaaat tacagaagct atacagtatg tggtggagtt tgccaaacgc     1020

attgatggat ttatggaact gtgtcaaaat gatcaaattg tgcttctaaa agcaggttct     1080

ctagaggtgg tgtttatcag aatgtgccgt gcctttgact ctcagaacaa caccgtgtac     1140

tttgatggga agtatgccag ccccgacgtc ttcaaatcct taggttgtga agactttatt     1200

agctttgtgt ttgaatttgg aaagagttta tgttctatgc acctgactga agatgaaatt     1260

gcattatttt ctgcatttgt actgatgtca gcagatcgct catggctgca agaaaaggta     1320

aaaattgaaa aactgcaaca gaaaattcag ctagctcttc aacacgtcct acagaagaat     1380

caccgagaag atggaatact aacaaagtta atatgcaagg tgtctacctt aagagcctta     1440

tgtggacgac atacagaaaa gctaatggca tttaaagcaa tatacccaga cattgtgcga     1500

cttcattttc ctccattata caaggagttg ttcacttcag aatttgagcc agcaatgcaa     1560

attgatgggt aa                                                         1572


<210>  8
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Ser Ala Pro Ala Ala Pro Asp Pro Ala Ala Ser Glu Pro Gly 
1               5                   10                  15      


Ser Ser Gly Ala Asp Ala Ala Ala Gly Ser Arg Glu Thr Pro Leu Asn 
            20                  25                  30          


Gln Glu Ser Ala Arg Lys Ser Glu Pro Pro Ala Pro Val Arg Arg Gln 
        35                  40                  45              


Ser Tyr Ser Ser Thr Ser Arg Gly Ile Ser Val Thr Lys Lys Thr His 
    50                  55                  60                  


Thr Ser Gln Ile Glu Ile Ile Pro Cys Lys Ile Cys Gly Asp Lys Ser 
65                  70                  75                  80  


Ser Gly Ile His Tyr Gly Val Ile Thr Cys Glu Gly Cys Lys Gly Phe 
                85                  90                  95      


Phe Arg Arg Ser Gln Gln Ser Asn Ala Thr Tyr Ser Cys Pro Arg Gln 
            100                 105                 110         


Lys Asn Cys Leu Ile Asp Arg Thr Ser Arg Asn Arg Cys Gln His Cys 
        115                 120                 125             


Arg Leu Gln Lys Cys Leu Ala Val Gly Met Ser Arg Asp Ala Val Lys 
    130                 135                 140                 


Phe Gly Arg Met Ser Lys Lys Gln Arg Asp Ser Leu Tyr Ala Glu Val 
145                 150                 155                 160 


Gln Lys His Arg Met Gln Gln Gln Gln Arg Asp His Gln Gln Gln Pro 
                165                 170                 175     


Gly Glu Ala Glu Pro Leu Thr Pro Thr Tyr Asn Ile Ser Ala Asn Gly 
            180                 185                 190         


Leu Thr Glu Leu His Asp Asp Leu Ser Asn Tyr Ile Asp Gly His Thr 
        195                 200                 205             


Pro Glu Gly Ser Lys Ala Asp Ser Ala Val Ser Ser Phe Tyr Leu Asp 
    210                 215                 220                 


Ile Gln Pro Ser Pro Asp Gln Ser Gly Leu Asp Ile Asn Gly Ile Lys 
225                 230                 235                 240 


Pro Glu Pro Ile Cys Asp Tyr Thr Pro Ala Ser Gly Phe Phe Pro Tyr 
                245                 250                 255     


Cys Ser Phe Thr Asn Gly Glu Thr Ser Pro Thr Val Ser Met Ala Glu 
            260                 265                 270         


Leu Glu His Leu Ala Gln Asn Ile Ser Lys Ser His Leu Glu Thr Cys 
        275                 280                 285             


Gln Tyr Leu Arg Glu Glu Leu Gln Gln Ile Thr Trp Gln Thr Phe Leu 
    290                 295                 300                 


Gln Glu Glu Ile Glu Asn Tyr Gln Asn Lys Gln Arg Glu Val Met Trp 
305                 310                 315                 320 


Gln Leu Cys Ala Ile Lys Ile Thr Glu Ala Ile Gln Tyr Val Val Glu 
                325                 330                 335     


Phe Ala Lys Arg Ile Asp Gly Phe Met Glu Leu Cys Gln Asn Asp Gln 
            340                 345                 350         


Ile Val Leu Leu Lys Ala Gly Ser Leu Glu Val Val Phe Ile Arg Met 
        355                 360                 365             


Cys Arg Ala Phe Asp Ser Gln Asn Asn Thr Val Tyr Phe Asp Gly Lys 
    370                 375                 380                 


Tyr Ala Ser Pro Asp Val Phe Lys Ser Leu Gly Cys Glu Asp Phe Ile 
385                 390                 395                 400 


Ser Phe Val Phe Glu Phe Gly Lys Ser Leu Cys Ser Met His Leu Thr 
                405                 410                 415     


Glu Asp Glu Ile Ala Leu Phe Ser Ala Phe Val Leu Met Ser Ala Asp 
            420                 425                 430         


Arg Ser Trp Leu Gln Glu Lys Val Lys Ile Glu Lys Leu Gln Gln Lys 
        435                 440                 445             


Ile Gln Leu Ala Leu Gln His Val Leu Gln Lys Asn His Arg Glu Asp 
    450                 455                 460                 


Gly Ile Leu Thr Lys Leu Ile Cys Lys Val Ser Thr Leu Arg Ala Leu 
465                 470                 475                 480 


Cys Gly Arg His Thr Glu Lys Leu Met Ala Phe Lys Ala Ile Tyr Pro 
                485                 490                 495     


Asp Ile Val Arg Leu His Phe Pro Pro Leu Tyr Lys Glu Leu Phe Thr 
            500                 505                 510         


Ser Glu Phe Glu Pro Ala Met Gln Ile Asp Gly 
        515                 520             


<210>  9
<211>  249
<212>  DNA
<213>  Homo sapiens

<400>  9
atggccacct tcccaccagc aaccagcgcc ccccagcagc ccccaggccc ggaggacgag       60

gactccagcc tggatgaatc tgacctctat agcctggccc attcctacct cggaggtgga      120

ggccggaaag gtcgcaccaa gagagaagct gctgccaaca ccaaccgccc cagccctggc      180

gggcacgaga ggaaactggt gaccaagctg cagaattcag agaggaagaa gcgaggggca      240

cggcgctga                                                              249


<210>  10
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Thr Phe Pro Pro Ala Thr Ser Ala Pro Gln Gln Pro Pro Gly 
1               5                   10                  15      


Pro Glu Asp Glu Asp Ser Ser Leu Asp Glu Ser Asp Leu Tyr Ser Leu 
            20                  25                  30          


Ala His Ser Tyr Leu Gly Gly Gly Gly Arg Lys Gly Arg Thr Lys Arg 
        35                  40                  45              


Glu Ala Ala Ala Asn Thr Asn Arg Pro Ser Pro Gly Gly His Glu Arg 
    50                  55                  60                  


Lys Leu Val Thr Lys Leu Gln Asn Ser Glu Arg Lys Lys Arg Gly Ala 
65                  70                  75                  80  


Arg Arg 
        


<210>  11
<211>  1812
<212>  DNA
<213>  Homo sapiens

<400>  11
atggcaacca tagaagaaat tgcacatcaa attattgaac aacagatggg agagattgtt       60

acagagcagc aaactgggca gaaaatccag attgtgacag cacttgatca taatacccaa      120

ggcaagcagt tcattctgac aaatcacgac ggctctactc caagcaaagt cattctggcc      180

aggcaagatt ccactccggg aaaagttttc cttacaactc cagatgcagc aggtgtcaac      240

cagttatttt ttaccactcc tgatctgtct gcacaacacc tgcagctcct aacagataat      300

tctccagacc aaggaccaaa taaggttttt gatctttgcg tagtatgtgg agacaaagca      360

tcaggacgtc attatggagc agtaacttgt gaaggctgca aaggattttt taaaagaagc      420

atccgaaaaa atttagtata ttcatgtcga ggatcaaagg attgtattat taataagcac      480

caccgaaacc gctgtcaata ctgcaggtta cagagatgta ttgcgtttgg aatgaagcaa      540

gactctgtcc aatgtgaaag aaaacccatt gaagtatcac gagaaaaatc ttccaactgt      600

gccgcttcaa cagaaaaaat ctatatccga aaggaccttc gtagcccatt aactgcaact      660

ccaacttttg taacagatag tgaaagtaca aggtcaacag gactgttaga ttcaggaatg      720

ttcatgaata ttcatccatc tggagtaaaa actgagtcag ctgtgctgat gacatcagat      780

aaggctgaat catgtcaggg agatttaagt acattggcca atgtggttac atcattagcg      840

aatcttggaa aaactaaaga tctttctcaa aatagtaatg aaatgtctat gattgaaagc      900

ttaagcaatg atgatacctc tttgtgtgaa tttcaagaaa tgcagaccaa cggtgatgtt      960

tcaagggcat ttgacactct tgcaaaagca ttgaatcctg gagagagcac agcctgccag     1020

agctcagtag cgggcatgga aggaagtgta cacctaatca ctggagattc aagcataaat     1080

tacaccgaaa aagaggggcc acttctcagc gattcacatg tagctttcag gctcaccatg     1140

ccttctccta tgcctgagta cctgaatgtg cactacattg gggagtctgc ctccagactg     1200

ctgttcttat caatgcactg ggcactttcg attccttctt tccaggctct agggcaagaa     1260

aacagcatat cactggtgaa agcttactgg aatgaacttt ttactcttgg tcttgcccag     1320

tgctggcaag tgatgaatgt agcaactata ttagcaacat ttgtcaattg tcttcacaat     1380

agtcttcaac aagataaaat gtcaacagaa agaagaaaat tattgatgga gcacatcttc     1440

aaactacagg agttttgtaa cagcatggtt aaactctgca ttgatggata cgaatatgcc     1500

tacctgaagg caatagtact cttcagtcca gatcatccaa gcctagaaaa catggaacag     1560

atagagaaat ttcaggaaaa ggcttatgtg gaattccaag attatataac caaaacatat     1620

ccagatgaca cctacaggtt atccagacta ctactcagat tgccagcttt aagactgatg     1680

aatgctacca tcactgaaga attgtttttc aaaggtctca ttggcaatat acgaattgac     1740

agtgttatcc cacatatttt gaaaatggag cctgcagatt ataactctca aataattggt     1800

cacagcattt ga                                                         1812


<210>  12
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Thr Ile Glu Glu Ile Ala His Gln Ile Ile Glu Gln Gln Met 
1               5                   10                  15      


Gly Glu Ile Val Thr Glu Gln Gln Thr Gly Gln Lys Ile Gln Ile Val 
            20                  25                  30          


Thr Ala Leu Asp His Asn Thr Gln Gly Lys Gln Phe Ile Leu Thr Asn 
        35                  40                  45              


His Asp Gly Ser Thr Pro Ser Lys Val Ile Leu Ala Arg Gln Asp Ser 
    50                  55                  60                  


Thr Pro Gly Lys Val Phe Leu Thr Thr Pro Asp Ala Ala Gly Val Asn 
65                  70                  75                  80  


Gln Leu Phe Phe Thr Thr Pro Asp Leu Ser Ala Gln His Leu Gln Leu 
                85                  90                  95      


Leu Thr Asp Asn Ser Pro Asp Gln Gly Pro Asn Lys Val Phe Asp Leu 
            100                 105                 110         


Cys Val Val Cys Gly Asp Lys Ala Ser Gly Arg His Tyr Gly Ala Val 
        115                 120                 125             


Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys Arg Ser Ile Arg Lys Asn 
    130                 135                 140                 


Leu Val Tyr Ser Cys Arg Gly Ser Lys Asp Cys Ile Ile Asn Lys His 
145                 150                 155                 160 


His Arg Asn Arg Cys Gln Tyr Cys Arg Leu Gln Arg Cys Ile Ala Phe 
                165                 170                 175     


Gly Met Lys Gln Asp Ser Val Gln Cys Glu Arg Lys Pro Ile Glu Val 
            180                 185                 190         


Ser Arg Glu Lys Ser Ser Asn Cys Ala Ala Ser Thr Glu Lys Ile Tyr 
        195                 200                 205             


Ile Arg Lys Asp Leu Arg Ser Pro Leu Thr Ala Thr Pro Thr Phe Val 
    210                 215                 220                 


Thr Asp Ser Glu Ser Thr Arg Ser Thr Gly Leu Leu Asp Ser Gly Met 
225                 230                 235                 240 


Phe Met Asn Ile His Pro Ser Gly Val Lys Thr Glu Ser Ala Val Leu 
                245                 250                 255     


Met Thr Ser Asp Lys Ala Glu Ser Cys Gln Gly Asp Leu Ser Thr Leu 
            260                 265                 270         


Ala Asn Val Val Thr Ser Leu Ala Asn Leu Gly Lys Thr Lys Asp Leu 
        275                 280                 285             


Ser Gln Asn Ser Asn Glu Met Ser Met Ile Glu Ser Leu Ser Asn Asp 
    290                 295                 300                 


Asp Thr Ser Leu Cys Glu Phe Gln Glu Met Gln Thr Asn Gly Asp Val 
305                 310                 315                 320 


Ser Arg Ala Phe Asp Thr Leu Ala Lys Ala Leu Asn Pro Gly Glu Ser 
                325                 330                 335     


Thr Ala Cys Gln Ser Ser Val Ala Gly Met Glu Gly Ser Val His Leu 
            340                 345                 350         


Ile Thr Gly Asp Ser Ser Ile Asn Tyr Thr Glu Lys Glu Gly Pro Leu 
        355                 360                 365             


Leu Ser Asp Ser His Val Ala Phe Arg Leu Thr Met Pro Ser Pro Met 
    370                 375                 380                 


Pro Glu Tyr Leu Asn Val His Tyr Ile Gly Glu Ser Ala Ser Arg Leu 
385                 390                 395                 400 


Leu Phe Leu Ser Met His Trp Ala Leu Ser Ile Pro Ser Phe Gln Ala 
                405                 410                 415     


Leu Gly Gln Glu Asn Ser Ile Ser Leu Val Lys Ala Tyr Trp Asn Glu 
            420                 425                 430         


Leu Phe Thr Leu Gly Leu Ala Gln Cys Trp Gln Val Met Asn Val Ala 
        435                 440                 445             


Thr Ile Leu Ala Thr Phe Val Asn Cys Leu His Asn Ser Leu Gln Gln 
    450                 455                 460                 


Asp Lys Met Ser Thr Glu Arg Arg Lys Leu Leu Met Glu His Ile Phe 
465                 470                 475                 480 


Lys Leu Gln Glu Phe Cys Asn Ser Met Val Lys Leu Cys Ile Asp Gly 
                485                 490                 495     


Tyr Glu Tyr Ala Tyr Leu Lys Ala Ile Val Leu Phe Ser Pro Asp His 
            500                 505                 510         


Pro Ser Leu Glu Asn Met Glu Gln Ile Glu Lys Phe Gln Glu Lys Ala 
        515                 520                 525             


Tyr Val Glu Phe Gln Asp Tyr Ile Thr Lys Thr Tyr Pro Asp Asp Thr 
    530                 535                 540                 


Tyr Arg Leu Ser Arg Leu Leu Leu Arg Leu Pro Ala Leu Arg Leu Met 
545                 550                 555                 560 


Asn Ala Thr Ile Thr Glu Glu Leu Phe Phe Lys Gly Leu Ile Gly Asn 
                565                 570                 575     


Ile Arg Ile Asp Ser Val Ile Pro His Ile Leu Lys Met Glu Pro Ala 
            580                 585                 590         


Asp Tyr Asn Ser Gln Ile Ile Gly His Ser Ile 
        595                 600             


<210>  13
<211>  1344
<212>  DNA
<213>  Homo sapiens

<400>  13
atgtccttgt ggctgggggc ccctgtgcct gacattcctc ctgactctgc ggtggagctg       60

tggaagccag gcgcacagga tgcaagcagc caggcccagg gaggcagcag ctgcatcctc      120

agagaggaag ccaggatgcc ccactctgct gggggtactg caggggtggg gctggaggct      180

gcagagccca cagccctgct caccagggca gagccccctt cagaacccac agagatccgt      240

ccacaaaagc ggaaaaaggg gccagccccc aaaatgctgg ggaacgagct atgcagcgtg      300

tgtggggaca aggcctcggg cttccactac aatgttctga gctgcgaggg ctgcaaggga      360

ttcttccgcc gcagcgtcat caagggagcg cactacatct gccacagtgg cggccactgc      420

cccatggaca cctacatgcg tcgcaagtgc caggagtgtc ggcttcgcaa atgccgtcag      480

gctggcatgc gggaggagtg tgtcctgtca gaagaacaga tccgcctgaa gaaactgaag      540

cggcaagagg aggaacaggc tcatgccaca tccttgcccc ccagggcttc ctcacccccc      600

caaatcctgc cccagctcag cccggaacaa ctgggcatga tcgagaagct cgtcgctgcc      660

cagcaacagt gtaaccggcg ctccttttct gaccggcttc gagtcacgcc ttggcccatg      720

gcaccagatc cccatagccg ggaggcccgt cagcagcgct ttgcccactt cactgagctg      780

gccatcgtct ctgtgcagga gatagttgac tttgctaaac agctacccgg cttcctgcag      840

ctcagccggg aggaccagat tgccctgctg aagacctctg cgatcgaggt gatgcttctg      900

gagacatctc ggaggtacaa ccctgggagt gagagtatca ccttcctcaa ggatttcagt      960

tataaccggg aagactttgc caaagcaggg ctgcaagtgg aattcatcaa ccccatcttc     1020

gagttctcca gggccatgaa tgagctgcaa ctcaatgatg ccgagtttgc cttgctcatt     1080

gctatcagca tcttctctgc agaccggccc aacgtgcagg accagctcca ggtagagagg     1140

ctgcagcaca catatgtgga agccctgcat gcctacgtct ccatccacca tccccatgac     1200

cgactgatgt tcccacggat gctaatgaaa ctggtgagcc tccggaccct gagcagcgtc     1260

cactcagagc aagtgtttgc actgcgtctg caggacaaaa agctcccacc gctgctctct     1320

gagatctggg atgtgcacga atga                                            1344


<210>  14
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Leu Trp Leu Gly Ala Pro Val Pro Asp Ile Pro Pro Asp Ser 
1               5                   10                  15      


Ala Val Glu Leu Trp Lys Pro Gly Ala Gln Asp Ala Ser Ser Gln Ala 
            20                  25                  30          


Gln Gly Gly Ser Ser Cys Ile Leu Arg Glu Glu Ala Arg Met Pro His 
        35                  40                  45              


Ser Ala Gly Gly Thr Ala Gly Val Gly Leu Glu Ala Ala Glu Pro Thr 
    50                  55                  60                  


Ala Leu Leu Thr Arg Ala Glu Pro Pro Ser Glu Pro Thr Glu Ile Arg 
65                  70                  75                  80  


Pro Gln Lys Arg Lys Lys Gly Pro Ala Pro Lys Met Leu Gly Asn Glu 
                85                  90                  95      


Leu Cys Ser Val Cys Gly Asp Lys Ala Ser Gly Phe His Tyr Asn Val 
            100                 105                 110         


Leu Ser Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Val Ile Lys 
        115                 120                 125             


Gly Ala His Tyr Ile Cys His Ser Gly Gly His Cys Pro Met Asp Thr 
    130                 135                 140                 


Tyr Met Arg Arg Lys Cys Gln Glu Cys Arg Leu Arg Lys Cys Arg Gln 
145                 150                 155                 160 


Ala Gly Met Arg Glu Glu Cys Val Leu Ser Glu Glu Gln Ile Arg Leu 
                165                 170                 175     


Lys Lys Leu Lys Arg Gln Glu Glu Glu Gln Ala His Ala Thr Ser Leu 
            180                 185                 190         


Pro Pro Arg Ala Ser Ser Pro Pro Gln Ile Leu Pro Gln Leu Ser Pro 
        195                 200                 205             


Glu Gln Leu Gly Met Ile Glu Lys Leu Val Ala Ala Gln Gln Gln Cys 
    210                 215                 220                 


Asn Arg Arg Ser Phe Ser Asp Arg Leu Arg Val Thr Pro Trp Pro Met 
225                 230                 235                 240 


Ala Pro Asp Pro His Ser Arg Glu Ala Arg Gln Gln Arg Phe Ala His 
                245                 250                 255     


Phe Thr Glu Leu Ala Ile Val Ser Val Gln Glu Ile Val Asp Phe Ala 
            260                 265                 270         


Lys Gln Leu Pro Gly Phe Leu Gln Leu Ser Arg Glu Asp Gln Ile Ala 
        275                 280                 285             


Leu Leu Lys Thr Ser Ala Ile Glu Val Met Leu Leu Glu Thr Ser Arg 
    290                 295                 300                 


Arg Tyr Asn Pro Gly Ser Glu Ser Ile Thr Phe Leu Lys Asp Phe Ser 
305                 310                 315                 320 


Tyr Asn Arg Glu Asp Phe Ala Lys Ala Gly Leu Gln Val Glu Phe Ile 
                325                 330                 335     


Asn Pro Ile Phe Glu Phe Ser Arg Ala Met Asn Glu Leu Gln Leu Asn 
            340                 345                 350         


Asp Ala Glu Phe Ala Leu Leu Ile Ala Ile Ser Ile Phe Ser Ala Asp 
        355                 360                 365             


Arg Pro Asn Val Gln Asp Gln Leu Gln Val Glu Arg Leu Gln His Thr 
    370                 375                 380                 


Tyr Val Glu Ala Leu His Ala Tyr Val Ser Ile His His Pro His Asp 
385                 390                 395                 400 


Arg Leu Met Phe Pro Arg Met Leu Met Lys Leu Val Ser Leu Arg Thr 
                405                 410                 415     


Leu Ser Ser Val His Ser Glu Gln Val Phe Ala Leu Arg Leu Gln Asp 
            420                 425                 430         


Lys Lys Leu Pro Pro Leu Leu Ser Glu Ile Trp Asp Val His Glu 
        435                 440                 445         


<210>  15
<211>  1593
<212>  DNA
<213>  Homo sapiens

<400>  15
atgactcgcg atttcaaacc tggagacctc atcttcgcca agatgaaagg ttatccccat       60

tggccagctc gagtagacga agttcctgat ggagctgtaa agccacccac aaacaaacta      120

cccattttct tttttggaac tcatgagact gcttttttag gaccaaagga tatatttcct      180

tactcagaaa ataaggaaaa gtatggcaaa ccaaataaaa gaaaaggttt taatgaaggt      240

ttatgggaga tagataacaa tccaaaagtg aaattttcaa gtcaacaggc agcaactaaa      300

caatcaaatg catcatctga tgttgaagtt gaagaaaagg aaactagtgt ttcaaaggaa      360

gataccgacc atgaagaaaa agccagcaat gaggatgtga ctaaagcagt tgacataact      420

actccaaaag ctgccagaag ggggagaaag agaaaggcag aaaaacaagt agaaactgag      480

gaggcaggag tagtgacaac agcaacagca tctgttaatc taaaagtgag tcctaaaaga      540

ggacgacctg cagctacaga agtcaagatt ccaaaaccaa gaggcagacc caaaatggta      600

aaacagccct gtccttcaga gagtgacatc attactgaag aggacaaaag taagaaaaag      660

gggcaagagg aaaaacaacc taaaaagcag cctaagaagg atgaagaggg ccagaaggaa      720

gaagataagc caagaaaaga gccggataaa aaagagggga agaaagaagt tgaatcaaaa      780

aggaaaaatt tagctaaaac aggggttact tcaacctccg attctgaaga agaaggagat      840

gatcaagaag gtgaaaagaa gagaaaaggt gggaggaact ttcagactgc tcacagaagg      900

aatatgctga aaggccaaca tgagaaagaa gcagcagatc gaaaacgcaa gcaagaggaa      960

caaatggaaa ctgagcagca gaataaagat gaaggaaaga agccagaagt taagaaagtg     1020

gagaagaagc gagaaacatc aatggattct cgacttcaaa ggatacatgc tgagattaaa     1080

aattcactca aaattgataa tcttgatgtg aacagatgca ttgaggcctt ggatgaactt     1140

gcttcacttc aggtcacaat gcaacaagct cagaaacaca cagagatgat tactacactg     1200

aaaaaaatac ggcgattcaa agttagtcag gtaatcatgg aaaagtctac aatgttgtat     1260

aacaagttta agaacatgtt cttggttggt gaaggagatt ccgtgatcac ccaagtgctg     1320

aataaatctc ttgctgaaca aagacagcat gaggaagcga ataaaaccaa agatcaaggg     1380

aagaaagggc caaacaaaaa gctagagaag gaacaaacag ggtcaaagac tctaaatgga     1440

ggatctgatg ctcaagatgg taatcagcca caacataacg gggagagcaa tgaagacagc     1500

aaagacaacc atgaagccag cacgaagaaa aagccatcca gtgaagagag agagactgaa     1560

atatctctga aggattctac actagataac tag                                  1593


<210>  16
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Thr Arg Asp Phe Lys Pro Gly Asp Leu Ile Phe Ala Lys Met Lys 
1               5                   10                  15      


Gly Tyr Pro His Trp Pro Ala Arg Val Asp Glu Val Pro Asp Gly Ala 
            20                  25                  30          


Val Lys Pro Pro Thr Asn Lys Leu Pro Ile Phe Phe Phe Gly Thr His 
        35                  40                  45              


Glu Thr Ala Phe Leu Gly Pro Lys Asp Ile Phe Pro Tyr Ser Glu Asn 
    50                  55                  60                  


Lys Glu Lys Tyr Gly Lys Pro Asn Lys Arg Lys Gly Phe Asn Glu Gly 
65                  70                  75                  80  


Leu Trp Glu Ile Asp Asn Asn Pro Lys Val Lys Phe Ser Ser Gln Gln 
                85                  90                  95      


Ala Ala Thr Lys Gln Ser Asn Ala Ser Ser Asp Val Glu Val Glu Glu 
            100                 105                 110         


Lys Glu Thr Ser Val Ser Lys Glu Asp Thr Asp His Glu Glu Lys Ala 
        115                 120                 125             


Ser Asn Glu Asp Val Thr Lys Ala Val Asp Ile Thr Thr Pro Lys Ala 
    130                 135                 140                 


Ala Arg Arg Gly Arg Lys Arg Lys Ala Glu Lys Gln Val Glu Thr Glu 
145                 150                 155                 160 


Glu Ala Gly Val Val Thr Thr Ala Thr Ala Ser Val Asn Leu Lys Val 
                165                 170                 175     


Ser Pro Lys Arg Gly Arg Pro Ala Ala Thr Glu Val Lys Ile Pro Lys 
            180                 185                 190         


Pro Arg Gly Arg Pro Lys Met Val Lys Gln Pro Cys Pro Ser Glu Ser 
        195                 200                 205             


Asp Ile Ile Thr Glu Glu Asp Lys Ser Lys Lys Lys Gly Gln Glu Glu 
    210                 215                 220                 


Lys Gln Pro Lys Lys Gln Pro Lys Lys Asp Glu Glu Gly Gln Lys Glu 
225                 230                 235                 240 


Glu Asp Lys Pro Arg Lys Glu Pro Asp Lys Lys Glu Gly Lys Lys Glu 
                245                 250                 255     


Val Glu Ser Lys Arg Lys Asn Leu Ala Lys Thr Gly Val Thr Ser Thr 
            260                 265                 270         


Ser Asp Ser Glu Glu Glu Gly Asp Asp Gln Glu Gly Glu Lys Lys Arg 
        275                 280                 285             


Lys Gly Gly Arg Asn Phe Gln Thr Ala His Arg Arg Asn Met Leu Lys 
    290                 295                 300                 


Gly Gln His Glu Lys Glu Ala Ala Asp Arg Lys Arg Lys Gln Glu Glu 
305                 310                 315                 320 


Gln Met Glu Thr Glu Gln Gln Asn Lys Asp Glu Gly Lys Lys Pro Glu 
                325                 330                 335     


Val Lys Lys Val Glu Lys Lys Arg Glu Thr Ser Met Asp Ser Arg Leu 
            340                 345                 350         


Gln Arg Ile His Ala Glu Ile Lys Asn Ser Leu Lys Ile Asp Asn Leu 
        355                 360                 365             


Asp Val Asn Arg Cys Ile Glu Ala Leu Asp Glu Leu Ala Ser Leu Gln 
    370                 375                 380                 


Val Thr Met Gln Gln Ala Gln Lys His Thr Glu Met Ile Thr Thr Leu 
385                 390                 395                 400 


Lys Lys Ile Arg Arg Phe Lys Val Ser Gln Val Ile Met Glu Lys Ser 
                405                 410                 415     


Thr Met Leu Tyr Asn Lys Phe Lys Asn Met Phe Leu Val Gly Glu Gly 
            420                 425                 430         


Asp Ser Val Ile Thr Gln Val Leu Asn Lys Ser Leu Ala Glu Gln Arg 
        435                 440                 445             


Gln His Glu Glu Ala Asn Lys Thr Lys Asp Gln Gly Lys Lys Gly Pro 
    450                 455                 460                 


Asn Lys Lys Leu Glu Lys Glu Gln Thr Gly Ser Lys Thr Leu Asn Gly 
465                 470                 475                 480 


Gly Ser Asp Ala Gln Asp Gly Asn Gln Pro Gln His Asn Gly Glu Ser 
                485                 490                 495     


Asn Glu Asp Ser Lys Asp Asn His Glu Ala Ser Thr Lys Lys Lys Pro 
            500                 505                 510         


Ser Ser Glu Glu Arg Glu Thr Glu Ile Ser Leu Lys Asp Ser Thr Leu 
        515                 520                 525             


Asp Asn 
    530 


<210>  17
<211>  738
<212>  DNA
<213>  Homo sapiens

<400>  17
ccaggtttga aaggaaaacg tggagacagt ggatcacctg caacctggac aacgagaggc       60

tttgtcttca cccgacacag tcaaaccaca gcaattcctt catgtccaga ggggacagtg      120

ccactctaca gtgggttttc ttttcttttt gtacaaggaa atcaacgagc ccacggacaa      180

gaccttggaa ctcttggcag ctgcctgcag cgatttacca caatgccatt cttattctgc      240

aatgtcaatg atgtatgtaa ttttgcatct cgaaatgatt attcatactg gctgtcaaca      300

ccagctctga tgccaatgaa catggctccc attactggca gagcccttga gccttatata      360

agcagatgca ctgtttgtga aggtcctgcg atcgccatag ccgttcacag ccaaaccact      420

gacattcctc catgtcctca cggctggatt tctctctgga aaggattttc attcatcatg      480

ttcacaagtg caggttctga gggcaccggg caagcactgg cctcccctgg ctcctgcctg      540

gaagaattcc gagccagccc atttctagaa tgtcatggaa gaggaacgtg caactactat      600

tcaaattcct acagtttctg gctggcttca ttaaacccag aaagaatgtt cagaaagcct      660

attccatcaa ctgtgaaagc tggggaatta gaaaaaataa taagtcgctg tcaggtgtgc      720

atgaagaaaa gacactga                                                    738


<210>  18
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  18

Pro Gly Leu Lys Gly Lys Arg Gly Asp Ser Gly Ser Pro Ala Thr Trp 
1               5                   10                  15      


Thr Thr Arg Gly Phe Val Phe Thr Arg His Ser Gln Thr Thr Ala Ile 
            20                  25                  30          


Pro Ser Cys Pro Glu Gly Thr Val Pro Leu Tyr Ser Gly Phe Ser Phe 
        35                  40                  45              


Leu Phe Val Gln Gly Asn Gln Arg Ala His Gly Gln Asp Leu Gly Thr 
    50                  55                  60                  


Leu Gly Ser Cys Leu Gln Arg Phe Thr Thr Met Pro Phe Leu Phe Cys 
65                  70                  75                  80  


Asn Val Asn Asp Val Cys Asn Phe Ala Ser Arg Asn Asp Tyr Ser Tyr 
                85                  90                  95      


Trp Leu Ser Thr Pro Ala Leu Met Pro Met Asn Met Ala Pro Ile Thr 
            100                 105                 110         


Gly Arg Ala Leu Glu Pro Tyr Ile Ser Arg Cys Thr Val Cys Glu Gly 
        115                 120                 125             


Pro Ala Ile Ala Ile Ala Val His Ser Gln Thr Thr Asp Ile Pro Pro 
    130                 135                 140                 


Cys Pro His Gly Trp Ile Ser Leu Trp Lys Gly Phe Ser Phe Ile Met 
145                 150                 155                 160 


Phe Thr Ser Ala Gly Ser Glu Gly Thr Gly Gln Ala Leu Ala Ser Pro 
                165                 170                 175     


Gly Ser Cys Leu Glu Glu Phe Arg Ala Ser Pro Phe Leu Glu Cys His 
            180                 185                 190         


Gly Arg Gly Thr Cys Asn Tyr Tyr Ser Asn Ser Tyr Ser Phe Trp Leu 
        195                 200                 205             


Ala Ser Leu Asn Pro Glu Arg Met Phe Arg Lys Pro Ile Pro Ser Thr 
    210                 215                 220                 


Val Lys Ala Gly Glu Leu Glu Lys Ile Ile Ser Arg Cys Gln Val Cys 
225                 230                 235                 240 


Met Lys Lys Arg His 
                245 


<210>  19
<211>  636
<212>  DNA
<213>  Homo sapiens

<400>  19
atgaggacct tggcttgcct gctgctcctc ggctgcggat acctcgccca tgttctggcc       60

gaggaagccg agatcccccg cgaggtgatc gagaggctgg cccgcagtca gatccacagc      120

atccgggacc tccagcgact cctggagata gactccgtag ggagtgagga ttctttggac      180

accagcctga gagctcacgg ggtccatgcc actaagcatg tgcccgagaa gcggcccctg      240

cccattcgga ggaagagaag catcgaggaa gctgtccccg ctgtctgcaa gaccaggacg      300

gtcatttacg agattcctcg gagtcaggtc gaccccacgt ccgccaactt cctgatctgg      360

cccccgtgcg tggaggtgaa acgctgcacc ggctgctgca acacgagcag tgtcaagtgc      420

cagccctccc gcgtccacca ccgcagcgtc aaggtggcca aggtggaata cgtcaggaag      480

aagccaaaat taaaagaagt ccaggtgagg ttagaggagc atttggagtg cgcctgcgcg      540

accacaagcc tgaatccgga ttatcgggaa gaggacacgg gaaggcctag ggagtcaggt      600

aaaaaacgga aaagaaaaag gttaaaaccc acctaa                                636


<210>  20
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Arg Thr Leu Ala Cys Leu Leu Leu Leu Gly Cys Gly Tyr Leu Ala 
1               5                   10                  15      


His Val Leu Ala Glu Glu Ala Glu Ile Pro Arg Glu Val Ile Glu Arg 
            20                  25                  30          


Leu Ala Arg Ser Gln Ile His Ser Ile Arg Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


Glu Ile Asp Ser Val Gly Ser Glu Asp Ser Leu Asp Thr Ser Leu Arg 
    50                  55                  60                  


Ala His Gly Val His Ala Thr Lys His Val Pro Glu Lys Arg Pro Leu 
65                  70                  75                  80  


Pro Ile Arg Arg Lys Arg Ser Ile Glu Glu Ala Val Pro Ala Val Cys 
                85                  90                  95      


Lys Thr Arg Thr Val Ile Tyr Glu Ile Pro Arg Ser Gln Val Asp Pro 
            100                 105                 110         


Thr Ser Ala Asn Phe Leu Ile Trp Pro Pro Cys Val Glu Val Lys Arg 
        115                 120                 125             


Cys Thr Gly Cys Cys Asn Thr Ser Ser Val Lys Cys Gln Pro Ser Arg 
    130                 135                 140                 


Val His His Arg Ser Val Lys Val Ala Lys Val Glu Tyr Val Arg Lys 
145                 150                 155                 160 


Lys Pro Lys Leu Lys Glu Val Gln Val Arg Leu Glu Glu His Leu Glu 
                165                 170                 175     


Cys Ala Cys Ala Thr Thr Ser Leu Asn Pro Asp Tyr Arg Glu Glu Asp 
            180                 185                 190         


Thr Gly Arg Pro Arg Glu Ser Gly Lys Lys Arg Lys Arg Lys Arg Leu 
        195                 200                 205             


Lys Pro Thr 
    210     


<210>  21
<211>  726
<212>  DNA
<213>  Homo sapiens

<400>  21
atgaatcgct gctgggcgct cttcctgtct ctctgctgct acctgcgtct ggtcagcgcc       60

gagggggacc ccattcccga ggagctttat gagatgctga gtgaccactc gatccgctcc      120

tttgatgatc tccaacgcct gctgcacgga gaccccggag aggaagatgg ggccgagttg      180

gacctgaaca tgacccgctc ccactctgga ggcgagctgg agagcttggc tcgtggaaga      240

aggagcctgg gttccctgac cattgctgag ccggccatga tcgccgagtg caagacgcgc      300

accgaggtgt tcgagatctc ccggcgcctc atagaccgca ccaacgccaa cttcctggtg      360

tggccgccct gtgtggaggt gcagcgctgc tccggctgct gcaacaaccg caacgtgcag      420

tgccgcccca cccaggtgca gctgcgacct gtccaggtga gaaagatcga gattgtgcgg      480

aagaagccaa tctttaagaa ggccacggtg acgctggaag accacctggc atgcaagtgt      540

gagacagtgg cagctgcacg gcctgtgacc cgaagcccgg ggggttccca ggagcagcga      600

gccaaaacgc cccaaactcg ggtgaccatt cggacggtgc gagtccgccg gccccccaag      660

ggcaagcacc ggaaattcaa gcacacgcat gacaagacgg cactgaagga gacccttgga      720

gcctag                                                                 726


<210>  22
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Asn Arg Cys Trp Ala Leu Phe Leu Ser Leu Cys Cys Tyr Leu Arg 
1               5                   10                  15      


Leu Val Ser Ala Glu Gly Asp Pro Ile Pro Glu Glu Leu Tyr Glu Met 
            20                  25                  30          


Leu Ser Asp His Ser Ile Arg Ser Phe Asp Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


His Gly Asp Pro Gly Glu Glu Asp Gly Ala Glu Leu Asp Leu Asn Met 
    50                  55                  60                  


Thr Arg Ser His Ser Gly Gly Glu Leu Glu Ser Leu Ala Arg Gly Arg 
65                  70                  75                  80  


Arg Ser Leu Gly Ser Leu Thr Ile Ala Glu Pro Ala Met Ile Ala Glu 
                85                  90                  95      


Cys Lys Thr Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp 
            100                 105                 110         


Arg Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln 
        115                 120                 125             


Arg Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Pro Thr 
    130                 135                 140                 


Gln Val Gln Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg 
145                 150                 155                 160 


Lys Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu 
                165                 170                 175     


Ala Cys Lys Cys Glu Thr Val Ala Ala Ala Arg Pro Val Thr Arg Ser 
            180                 185                 190         


Pro Gly Gly Ser Gln Glu Gln Arg Ala Lys Thr Pro Gln Thr Arg Val 
        195                 200                 205             


Thr Ile Arg Thr Val Arg Val Arg Arg Pro Pro Lys Gly Lys His Arg 
    210                 215                 220                 


Lys Phe Lys His Thr His Asp Lys Thr Ala Leu Lys Glu Thr Leu Gly 
225                 230                 235                 240 


Ala 
    


<210>  23
<211>  468
<212>  DNA
<213>  Homo sapiens

<400>  23
atggctgaag gggaaatcac caccttcaca gccctgaccg agaagtttaa tctgcctcca       60

gggaattaca agaagcccaa actcctctac tgtagcaacg ggggccactt cctgaggatc      120

cttccggatg gcacagtgga tgggacaagg gacaggagcg accagcacat tcagctgcag      180

ctcagtgcgg aaagcgtggg ggaggtgtat ataaagagta ccgagactgg ccagtacttg      240

gccatggaca ccgacgggct tttatacggc tcacagacac caaatgagga atgtttgttc      300

ctggaaaggc tggaggagaa ccattacaac acctatatat ccaagaagca tgcagagaag      360

aattggtttg ttggcctcaa gaagaatggg agctgcaaac gcggtcctcg gactcactat      420

ggccagaaag caatcttgtt tctccccctg ccagtctctt ctgattaa                   468


<210>  24
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      


Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  


Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  


Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      


Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         


Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             


Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 


<210>  25
<211>  11430
<212>  DNA
<213>  Homo sapiens

<400>  25
atgccaccta atataaactg gaaagaaata atgaaagttg acccagatga cctgccccgt       60

caagaagaac tggcagataa tttattgatt tccttatcca aggtggaagt aaatgagcta      120

aaaagtgaaa agcaagaaaa tgtgatacac cttttcagaa ttactcagtc actaatgaag      180

atgaaagctc aagaagtgga gctggctttg gaagaagtag aaaaagctgg agaagaacaa      240

gcaaaatttg aaaatcaatt aaaaactaaa gtaatgaaac tggaaaatga actggagatg      300

gctcagcagt ctgcaggtgg acgagatact cggtttttac gtaatgaaat ttgccaactt      360

gaaaaacaat tagaacaaaa agatagagaa ttggaggaca tggaaaagga gttggagaaa      420

gagaagaaag ttaatgagca attggctctt cgaaatgagg aggcagaaaa tgaaaacagc      480

aaattaagaa gagagaacaa acgtctaaag aaaaagaatg aacaactttg tcaggatatt      540

attgactacc agaaacaaat agattcacag aaagaaacac ttttatcaag aagaggggaa      600

gacagtgact accgatcaca gttgtctaaa aaaaactatg agcttatcca atatcttgat      660

gaaattcaga ctttaacaga agctaatgag aaaattgaag ttcagaatca agaaatgaga      720

aaaaatttag aagagtctgt acaggaaatg gagaagatga ctgatgaata taatagaatg      780

aaagctattg tgcatcagac agataatgta atagatcagt taaaaaaaga aaacgatcat      840

tatcaacttc aagtgcagga gcttacagat cttctgaaat caaaaaatga agaagatgat      900

ccaattatgg tagctgtcaa tgcaaaagta gaagaatgga agctaatttt gtcttctaaa      960

gatgatgaaa ttattgagta tcagcaaatg ttacataacc taagggagaa acttaagaat     1020

gctcagcttg atgctgataa aagtaatgtt atggctctac agcagggtat acaggaacga     1080

gacagtcaaa ttaagatgct caccgaacaa gtagaacaat atacaaaaga aatggaaaag     1140

aatacttgta ttattgaaga tttgaaaaat gagctccaaa gaaacaaagg tgcttcaacc     1200

ctttctcaac agactcatat gaaaattcag tcaacgttag acattttaaa agagaaaact     1260

aaagaggctg agagaacagc tgaactggct gaggctgatg ctagggaaaa ggataaagaa     1320

ttagttgagg ctctgaagag gttaaaagat tatgaatcgg gagtatatgg tttagaagat     1380

gctgtcgttg aaataaagaa ttgtaaaaac caaattaaaa taagagatcg agagattgaa     1440

atattaacaa aggaaatcaa taaacttgaa ttgaagatca gtgatttcct tgatgaaaat     1500

gaggcactta gagagcgtgt gggccttgaa ccaaagacaa tgattgattt aactgaattt     1560

agaaatagca aacacttaaa acagcagcag tacagagctg aaaaccagat tcttttgaaa     1620

gagattgaaa gtctagagga agaacgactt gatctgaaaa aaaaaattcg tcaaatggct     1680

caagaaagag gaaaaagaag tgcaacttca ggattaacca ctgaggacct gaacctaact     1740

gaaaacattt ctcaaggaga tagaataagt gaaagaaaat tggatttatt gagcctcaaa     1800

aatatgagtg aagcacaatc aaagaatgaa tttctttcaa gagaactaat tgaaaaagaa     1860

agagatttag aaaggagtag gacagtgata gccaaatttc agaataaatt aaaagaatta     1920

gttgaagaaa ataagcaact tgaagaaggt atgaaagaaa tattgcaagc aattaaggaa     1980

atgcagaaag atcctgatgt taaaggagga gaaacatctc taattatccc tagccttgaa     2040

agactagtta atgctataga atcaaagaat gcagaaggaa tctttgatgc gagtctgcat     2100

ttgaaagccc aagttgatca gcttaccgga agaaatgaag aattaagaca ggagctcagg     2160

gaatctcgga aagaggctat aaattattca cagcagttgg caaaagctaa tttaaagata     2220

gaccatcttg aaaaagaaac tagtctttta cgacaatcag aaggatcaaa tgttgttttt     2280

aaaggaattg acttacctga tgggatagca ccatctagtg ccagtatcat taattctcag     2340

aatgaatatt taatacattt gttacaggaa ctagaaaata aagaaaaaaa gttaaagaat     2400

ttagaagatt ctcttgaaga ttacaacaga aaatttgctg taattcgtca tcaacaaagt     2460

ttgttgtata aagaatacct aagtgaaaag gagacctgga aaacagaatc taaaacaata     2520

aaagaggaaa agagaaaact tgaggatcaa gtccaacaag atgctataaa agtaaaagaa     2580

tataataatt tgctcaatgc tcttcagatg gattcggatg aaatgaaaaa aatacttgca     2640

gaaaatagta ggaaaattac tgttttgcaa gtgaatgaaa aatcacttat aaggcaatat     2700

acaaccttag tagaattgga gcgacaactt agaaaagaaa atgagaagca aaagaatgaa     2760

ttgttgtcaa tggaggctga agtttgtgaa aaaattgggt gtttgcaaag atttaaggaa     2820

atggccattt tcaagattgc agctctccaa aaagttgtag ataatagtgt ttctttgtct     2880

gaactagaac tggctaataa acagtacaat gaactgactg ctaagtacag ggacatcttg     2940

caaaaagata atatgcttgt tcaaagaaca agtaacttgg aacacctgga gtgtgaaaac     3000

atctccttaa aagaacaagt ggagtctata aataaagaac tggagattac caaggaaaaa     3060

cttcacacta ttgaacaagc ctgggaacag gaaactaaat taggtaatga atctagcatg     3120

gataaggcaa agaaatcaat aaccaacagt gacattgttt ccatttcaaa aaaaataact     3180

atgctggaaa tgaaggaatt aaatgaaagg cagcgggctg aacattgtca aaaaatgtat     3240

gaacacttac ggacttcgtt aaagcaaatg gaggaacgta attttgaatt ggaaaccaaa     3300

tttgctgagc ttaccaaaat caatttggat gcacagaagg tggaacagat gttaagagat     3360

gaattagctg atagtgtgag caaggcagta agtgatgctg ataggcaacg gattctagaa     3420

ttagagaaga atgaaatgga actaaaagtt gaagtgtcaa aactgagaga gatttctgat     3480

attgccagaa gacaagttga aattttgaat gcacaacaac aatctaggga caaggaagta     3540

gagtccctca gaatgcaact gctagactat caggcacagt ctgatgaaaa gtcgctcatt     3600

gccaagttgc accaacataa tgtctctctt caactgagtg aggctactgc tcttggtaag     3660

ttggagtcaa ttacatctaa actgcagaag atggaggcct acaacttgcg cttagagcag     3720

aaacttgatg aaaaagaaca ggctctctat tatgctcgtt tggagggaag aaacagagca     3780

aaacatctgc gccaaacaat tcagtctcta cgacgacagt ttagtggagc tttacccttg     3840

gcacaacagg aaaagttctc caaaacaatg attcaactac aaaatgacaa acttaagata     3900

atgcaagaaa tgaaaaattc tcaacaagaa catagaaata tggagaacaa aacattggag     3960

atggaattaa aattaaaggg cctggaagag ttaataagca ctttaaagga taccaaagga     4020

gcccaaaagg taatcaactg gcatatgaaa atagaagaac ttcgtcttca agaacttaaa     4080

ctaaatcggg aattagtcaa ggataaagaa gaaataaaat atttgaataa cataatttct     4140

gaatatgaac gtacaatcag cagtcttgaa gaagaaattg tgcaacagaa caagtttcat     4200

gaagaaagac aaatggcctg ggatcaaaga gaagttgacc tggaacgcca actagacatt     4260

tttgaccgtc agcaaaatga aatactaaat gcggcacaaa agtttgaaga agctacagga     4320

tcaatccctg accctagttt gccccttcca aatcaacttg agatcgctct aaggaaaatt     4380

aaggagaaca ttcgaataat tctagaaaca cgggcaactt gcaaatcact agaagagaaa     4440

ctaaaagaga aagaatctgc tttaaggtta gcagaacaaa atatactgtc aagagacaaa     4500

gtaatcaatg aactgaggct tcgattgcct gccactgcag aaagagaaaa gctcatagct     4560

gagctaggca gaaaagagat ggaaccaaaa tctcaccaca cattgaaaat tgctcatcaa     4620

accattgcaa acatgcaagc aaggttaaat caaaaagaag aagtattaaa gaagtatcaa     4680

cgtcttctag aaaaagccag agaggagcaa agagaaattg tgaagaaaca tgaggaagac     4740

cttcatattc ttcatcacag attagaacta caggctgata gttcactaaa taaattcaaa     4800

caaacggctt gggatttaat gaaacagtct cccactccag ttcctaccaa caagcatttt     4860

attcgtctgg ctgagatgga acagacagta gcagaacaag atgactctct ttcctcactc     4920

ttggtcaaac taaagaaagt atcacaagat ttggagagac aaagagaaat cactgaatta     4980

aaagtaaaag aatttgaaaa tatcaaatta cagcttcaag aaaaccatga agatgaagtg     5040

aaaaaagtaa aagcggaagt agaggattta aagtatcttc tggaccagtc acaaaaggag     5100

tcacagtgtt taaaatctga acttcaggct caaaaagaag caaattcaag agctccaaca     5160

actacaatga gaaatctagt agaacggcta aagagccaat tagccttgaa ggagaaacaa     5220

cagaaagcac ttagtcgggc acttttagaa ctccgggcag aaatgacagc agctgctgaa     5280

gaacgtatta tttctgcaac ttctcaaaaa gaggcccatc tcaatgttca acaaatcgtt     5340

gatcgacata ctagagagct aaagacacaa gttgaagatt taaatgaaaa tcttttaaaa     5400

ttgaaagaag cacttaaaac aagtaaaaac agagaaaact cactaactga taatttgaat     5460

gacttaaata atgaactgca aaagaaacaa aaagcctata ataaaatact tagagagaaa     5520

gaggaaattg atcaagagaa tgatgaactg aaaaggcaaa ttaaaagact aaccagtgga     5580

ttacagggca aacccctgac agataataaa caaagtctaa ttgaagaact ccaaaggaaa     5640

gttaaaaaac tagagaacca attagaggga aaggtggagg aagtagacct aaaacctatg     5700

aaagaaaaga atgctaaaga agaattaatt aggtgggaag aaggtaaaaa gtggcaagcc     5760

aaaatagaag gaattcgaaa caagttaaaa gagaaagagg gggaagtctt tactttaaca     5820

aagcagttga atactttgaa ggatcttttt gccaaagccg ataaagagaa acttactttg     5880

cagaggaaac taaaaacaac tggcatgact gttgatcagg ttttgggaat acgagctttg     5940

gagtcagaaa aagaattgga agaattaaaa aagagaaatc ttgacttaga aaatgatata     6000

ttgtatatga gggcccacca agctcttcct cgagattctg ttgtagaaga tttacattta     6060

caaaatagat acctccaaga aaaacttcat gctttagaaa aacagttttc aaaggataca     6120

tattctaagc cttcaatttc aggaatagag tcagatgatc attgtcagag agaacaggag     6180

cttcagaagg aaaacttgaa gttgtcatct gaaaatattg aactgaaatt tcagcttgaa     6240

caagcaaata aagatttgcc aagattaaag aatcaagtca gagatttgaa ggaaatgtgt     6300

gaatttctta agaaagaaaa agcagaagtt cagcggaaac ttggccatgt tagagggtct     6360

ggtagaagtg gaaagacaat cccagaactg gaaaaaacca ttggtttaat gaaaaaagta     6420

gttgaaaaag tccagagaga aaatgaacag ttgaaaaaag catcaggaat attgactagt     6480

gaaaaaatgg ctaatattga gcaggaaaat gaaaaattga aggctgaatt agaaaaactt     6540

aaagctcatc ttgggcatca gttgagcatg cactatgaat ccaagaccaa aggcacagaa     6600

aaaattattg ctgaaaatga aaggcttcgt aaagaactta aaaaagaaac tgatgctgca     6660

gagaaattac ggatagcaaa gaataattta gagatattaa atgagaagat gacagttcaa     6720

ctagaagaga ctggtaagag attgcagttt gcagaaagca gaggtccaca gcttgaaggt     6780

gctgacagta agagctggaa atccattgtg gttacaagaa tgtatgaaac caagttaaaa     6840

gaattggaaa ctgatattgc caaaaaaaat caaagcatta ctgaccttaa acagcttgta     6900

aaagaagcaa cagagagaga acaaaaagtt aacaaataca atgaagacct tgaacaacag     6960

attaagattc ttaaacatgt tcctgaaggt gctgagacag agcaaggcct taaacgggag     7020

cttcaagttc ttagattagc taatcatcag ctggataaag agaaagcaga attaatccat     7080

cagatagaag ctaacaagga ccaaagtgga gctgaaagca ccatacctga tgctgatcaa     7140

ctaaaggaaa aaataaaaga tctagagaca cagctcaaaa tgtcagatct agaaaagcag     7200

catttgaagg aggaaataaa gaagctgaaa aaagaactgg aaaattttga tccttcattt     7260

tttgaagaaa ttgaagatct taagtataat tacaaggaag aagtgaagaa gaatattctc     7320

ttagaagaga aggtaaaaaa actttcagaa caattgggag ttgaattaac tagccctgtt     7380

gctgcttctg aagagtttga agatgaagaa gaaagtcctg atgaaatgga actaaaagtt     7440

gaagtgtcaa aactgagaga gatttctgat attgccagaa gacaagttga aattttgaat     7500

gcacaacaac aatctaggga caaggaagta gagtccctca gaatgcaact gctagactat     7560

caggcacagt ctgatgaaaa gtcgctcatt gccaagttgc accaacataa tgtctctctt     7620

caactgagtg aggctactgc tcttggtaag ttggagtcaa ttacatctaa actgcagaag     7680

atggaggcct acaacttgcg cttagagcag aaacttgatg aaaaagaaca ggctctctat     7740

tatgctcgtt tggagggaag aaacagagca aaacatctgc gccaaacaat tcagtctcta     7800

cgacgacagt ttagtggagc tttacccttg gcacaacagg aaaagttctc caaaacaatg     7860

attcaactac aaaatgacaa acttaagata atgcaagaaa tgaaaaattc tcaacaagaa     7920

catagaaata tggagaacaa aacattggag atggaattaa aattaaaggg cctggaagag     7980

ttaataagca ctttaaagga taccaaagga gcccaaaagg taatcaactg gcatatgaaa     8040

atagaagaac ttcgtcttca agaacttaaa ctaaatcggg aattagtcaa ggataaagaa     8100

gaaataaaat atttgaataa cataatttct gaatatgaac gtacaatcag cagtcttgaa     8160

gaagaaattg tgcaacagaa caagtttcat gaagaaagac aaatggcctg ggatcaaaga     8220

gaagttgacc tggaacgcca actagacatt tttgaccgtc agcaaaatga aatactaaat     8280

gcggcacaaa agtttgaaga agctacagga tcaatccctg accctagttt gccccttcca     8340

aatcaacttg agatcgctct aaggaaaatt aaggagaaca ttcgaataat tctagaaaca     8400

cgggcaactt gcaaatcact agaagagaaa ctaaaagaga aagaatctgc tttaaggtta     8460

gcagaacaaa atatactgtc aagagacaaa gtaatcaatg aactgaggct tcgattgcct     8520

gccactgcag aaagagaaaa gctcatagct gagctaggca gaaaagagat ggaaccaaaa     8580

tctcaccaca cattgaaaat tgctcatcaa accattgcaa acatgcaagc aaggttaaat     8640

caaaaagaag aagtattaaa gaagtatcaa cgtcttctag aaaaagccag agaggagcaa     8700

agagaaattg tgaagaaaca tgaggaagac cttcatattc ttcatcacag attagaacta     8760

caggctgata gttcactaaa taaattcaaa caaacggctt gggatttaat gaaacagtct     8820

cccactccag ttcctaccaa caagcatttt attcgtctgg ctgagatgga acagacagta     8880

gcagaacaag atgactctct ttcctcactc ttggtcaaac taaagaaagt atcacaagat     8940

ttggagagac aaagagaaat cactgaatta aaagtaaaag aatttgaaaa tatcaaatta     9000

cagcttcaag aaaaccatga agatgaagtg aaaaaagtaa aagcggaagt agaggattta     9060

aagtatcttc tggaccagtc acaaaaggag tcacagtgtt taaaatctga acttcaggct     9120

caaaaagaag caaattcaag agctccaaca actacaatga gaaatctagt agaacggcta     9180

aagagccaat tagccttgaa ggagaaacaa cagaaagcac ttagtcgggc acttttagaa     9240

ctccgggcag aaatgacagc agctgctgaa gaacgtatta tttctgcaac ttctcaaaaa     9300

gaggcccatc tcaatgttca acaaatcgtt gatcgacata ctagagagct aaagacacaa     9360

gttgaagatt taaatgaaaa tcttttaaaa ttgaaagaag cacttaaaac aagtaaaaac     9420

agagaaaact cactaactga taatttgaat gacttaaata atgaactgca aaagaaacaa     9480

aaagcctata ataaaatact tagagagaaa gaggaaattg atcaagagaa tgatgaactg     9540

aaaaggcaaa ttaaaagact aaccagtgga ttacagggca aacccctgac agataataaa     9600

caaagtctaa ttgaagaact ccaaaggaaa gttaaaaaac tagagaacca attagaggga     9660

aaggtggagg aagtagacct aaaacctatg aaagaaaaga atgctaaaga agaattaatt     9720

aggtgggaag aaggtaaaaa gtggcaagcc aaaatagaag gaattcgaaa caagttaaaa     9780

gagaaagagg gggaagtctt tactttaaca aagcagttga atactttgaa ggatcttttt     9840

gccaaagccg ataaagagaa acttactttg cagaggaaac taaaaacaac tggcatgact     9900

gttgatcagg ttttgggaat acgagctttg gagtcagaaa aagaattgga agaattaaaa     9960

aagagaaatc ttgacttaga aaatgatata ttgtatatga gggcccacca agctcttcct    10020

cgagattctg ttgtagaaga tttacattta caaaatagat acctccaaga aaaacttcat    10080

gctttagaaa aacagttttc aaaggataca tattctaagc cttcaatttc aggaatagag    10140

tcagatgatc attgtcagag agaacaggag cttcagaagg aaaacttgaa gttgtcatct    10200

gaaaatattg aactgaaatt tcagcttgaa caagcaaata aagatttgcc aagattaaag    10260

aatcaagtca gagatttgaa ggaaatgtgt gaatttctta agaaagaaaa agcagaagtt    10320

cagcggaaac ttggccatgt tagagggtct ggtagaagtg gaaagacaat cccagaactg    10380

gaaaaaacca ttggtttaat gaaaaaagta gttgaaaaag tccagagaga aaatgaacag    10440

ttgaaaaaag catcaggaat attgactagt gaaaaaatgg ctaatattga gcaggaaaat    10500

gaaaaattga aggctgaatt agaaaaactt aaagctcatc ttgggcatca gttgagcatg    10560

cactatgaat ccaagaccaa aggcacagaa aaaattattg ctgaaaatga aaggcttcgt    10620

aaagaactta aaaaagaaac tgatgctgca gagaaattac ggatagcaaa gaataattta    10680

gagatattaa atgagaagat gacagttcaa ctagaagaga ctggtaagag attgcagttt    10740

gcagaaagca gaggtccaca gcttgaaggt gctgacagta agagctggaa atccattgtg    10800

gttacaagaa tgtatgaaac caagttaaaa gaattggaaa ctgatattgc caaaaaaaat    10860

caaagcatta ctgaccttaa acagcttgta aaagaagcaa cagagagaga acaaaaagtt    10920

aacaaataca atgaagacct tgaacaacag attaagattc ttaaacatgt tcctgaaggt    10980

gctgagacag agcaaggcct taaacgggag cttcaagttc ttagattagc taatcatcag    11040

ctggataaag agaaagcaga attaatccat cagatagaag ctaacaagga ccaaagtgga    11100

gctgaaagca ccatacctga tgctgatcaa ctaaaggaaa aaataaaaga tctagagaca    11160

cagctcaaaa tgtcagatct agaaaagcag catttgaagg aggaaataaa gaagctgaaa    11220

aaagaactgg aaaattttga tccttcattt tttgaagaaa ttgaagatct taagtataat    11280

tacaaggaag aagtgaagaa gaatattctc ttagaagaga aggtaaaaaa actttcagaa    11340

caattgggag ttgaattaac tagccctgtt gctgcttctg aagagtttga agatgaagaa    11400

gaaagtcctg ttaatttccc catttactaa                                     11430


<210>  26
<211>  2479
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Asn Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu 
    610                 615                 620                 


Arg Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu 
625                 630                 635                 640 


Val Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln 
                645                 650                 655     


Ala Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr 
            660                 665                 670         


Ser Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser 
        675                 680                 685             


Lys Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln 
    690                 695                 700                 


Val Asp Gln Leu Thr Gly Arg Asn Glu Glu Leu Arg Gln Glu Leu Arg 
705                 710                 715                 720 


Glu Ser Arg Lys Glu Ala Ile Asn Tyr Ser Gln Gln Leu Ala Lys Ala 
                725                 730                 735     


Asn Leu Lys Ile Asp His Leu Glu Lys Glu Thr Ser Leu Leu Arg Gln 
            740                 745                 750         


Ser Glu Gly Ser Asn Val Val Phe Lys Gly Ile Asp Leu Pro Asp Gly 
        755                 760                 765             


Ile Ala Pro Ser Ser Ala Ser Ile Ile Asn Ser Gln Asn Glu Tyr Leu 
    770                 775                 780                 


Ile His Leu Leu Gln Glu Leu Glu Asn Lys Glu Lys Lys Leu Lys Asn 
785                 790                 795                 800 


Leu Glu Asp Ser Leu Glu Asp Tyr Asn Arg Lys Phe Ala Val Ile Arg 
                805                 810                 815     


His Gln Gln Ser Leu Leu Tyr Lys Glu Tyr Leu Ser Glu Lys Glu Thr 
            820                 825                 830         


Trp Lys Thr Glu Ser Lys Thr Ile Lys Glu Glu Lys Arg Lys Leu Glu 
        835                 840                 845             


Asp Gln Val Gln Gln Asp Ala Ile Lys Val Lys Glu Tyr Asn Asn Leu 
    850                 855                 860                 


Leu Asn Ala Leu Gln Met Asp Ser Asp Glu Met Lys Lys Ile Leu Ala 
865                 870                 875                 880 


Glu Asn Ser Arg Lys Ile Thr Val Leu Gln Val Asn Glu Lys Ser Leu 
                885                 890                 895     


Ile Arg Gln Tyr Thr Thr Leu Val Glu Leu Glu Arg Gln Leu Arg Lys 
            900                 905                 910         


Glu Asn Glu Lys Gln Lys Asn Glu Leu Leu Ser Met Glu Ala Glu Val 
        915                 920                 925             


Cys Glu Lys Ile Gly Cys Leu Gln Arg Phe Lys Glu Met Ala Ile Phe 
    930                 935                 940                 


Lys Ile Ala Ala Leu Gln Lys Val Val Asp Asn Ser Val Ser Leu Ser 
945                 950                 955                 960 


Glu Leu Glu Leu Ala Asn Lys Gln Tyr Asn Glu Leu Thr Ala Lys Tyr 
                965                 970                 975     


Arg Asp Ile Leu Gln Lys Asp Asn Met Leu Val Gln Arg Thr Ser Asn 
            980                 985                 990         


Leu Glu His Leu Glu Cys Glu Asn  Ile Ser Leu Lys Glu  Gln Val Glu 
        995                 1000                 1005             


Ser Ile  Asn Lys Glu Leu Glu  Ile Thr Lys Glu Lys  Leu His Thr 
    1010                 1015                 1020             


Ile Glu  Gln Ala Trp Glu Gln  Glu Thr Lys Leu Gly  Asn Glu Ser 
    1025                 1030                 1035             


Ser Met  Asp Lys Ala Lys Lys  Ser Ile Thr Asn Ser  Asp Ile Val 
    1040                 1045                 1050             


Ser Ile  Ser Lys Lys Ile Thr  Met Leu Glu Met Lys  Glu Leu Asn 
    1055                 1060                 1065             


Glu Arg  Gln Arg Ala Glu His  Cys Gln Lys Met Tyr  Glu His Leu 
    1070                 1075                 1080             


Arg Thr  Ser Leu Lys Gln Met  Glu Glu Arg Asn Phe  Glu Leu Glu 
    1085                 1090                 1095             


Thr Lys  Phe Ala Glu Leu Thr  Lys Ile Asn Leu Asp  Ala Gln Lys 
    1100                 1105                 1110             


Val Glu  Gln Met Leu Arg Asp  Glu Leu Ala Asp Ser  Val Ser Lys 
    1115                 1120                 1125             


Ala Val  Ser Asp Ala Asp Arg  Gln Arg Ile Leu Glu  Leu Glu Lys 
    1130                 1135                 1140             


Asn Glu  Met Glu Leu Lys Val  Glu Val Ser Lys Leu  Arg Glu Ile 
    1145                 1150                 1155             


Ser Asp  Ile Ala Arg Arg Gln  Val Glu Ile Leu Asn  Ala Gln Gln 
    1160                 1165                 1170             


Gln Ser  Arg Asp Lys Glu Val  Glu Ser Leu Arg Met  Gln Leu Leu 
    1175                 1180                 1185             


Asp Tyr  Gln Ala Gln Ser Asp  Glu Lys Ser Leu Ile  Ala Lys Leu 
    1190                 1195                 1200             


His Gln  His Asn Val Ser Leu  Gln Leu Ser Glu Ala  Thr Ala Leu 
    1205                 1210                 1215             


Gly Lys  Leu Glu Ser Ile Thr  Ser Lys Leu Gln Lys  Met Glu Ala 
    1220                 1225                 1230             


Tyr Asn  Leu Arg Leu Glu Gln  Lys Leu Asp Glu Lys  Glu Gln Ala 
    1235                 1240                 1245             


Leu Tyr  Tyr Ala Arg Leu Glu  Gly Arg Asn Arg Ala  Lys His Leu 
    1250                 1255                 1260             


Arg Gln  Thr Ile Gln Ser Leu  Arg Arg Gln Phe Ser  Gly Ala Leu 
    1265                 1270                 1275             


Pro Leu  Ala Gln Gln Glu Lys  Phe Ser Lys Thr Met  Ile Gln Leu 
    1280                 1285                 1290             


Gln Asn  Asp Lys Leu Lys Ile  Met Gln Glu Met Lys  Asn Ser Gln 
    1295                 1300                 1305             


Gln Glu  His Arg Asn Met Glu  Asn Lys Thr Leu Glu  Met Glu Leu 
    1310                 1315                 1320             


Lys Leu  Lys Gly Leu Glu Glu  Leu Ile Ser Thr Leu  Lys Asp Thr 
    1325                 1330                 1335             


Lys Gly  Ala Gln Lys Val Ile  Asn Trp His Met Lys  Ile Glu Glu 
    1340                 1345                 1350             


Leu Arg  Leu Gln Glu Leu Lys  Leu Asn Arg Glu Leu  Val Lys Asp 
    1355                 1360                 1365             


Lys Glu  Glu Ile Lys Tyr Leu  Asn Asn Ile Ile Ser  Glu Tyr Glu 
    1370                 1375                 1380             


Arg Thr  Ile Ser Ser Leu Glu  Glu Glu Ile Val Gln  Gln Asn Lys 
    1385                 1390                 1395             


Phe His  Glu Glu Arg Gln Met  Ala Trp Asp Gln Arg  Glu Val Asp 
    1400                 1405                 1410             


Leu Glu  Arg Gln Leu Asp Ile  Phe Asp Arg Gln Gln  Asn Glu Ile 
    1415                 1420                 1425             


Leu Asn  Ala Ala Gln Lys Phe  Glu Glu Ala Thr Gly  Ser Ile Pro 
    1430                 1435                 1440             


Asp Pro  Ser Leu Pro Leu Pro  Asn Gln Leu Glu Ile  Ala Leu Arg 
    1445                 1450                 1455             


Lys Ile  Lys Glu Asn Ile Arg  Ile Ile Leu Glu Thr  Arg Ala Thr 
    1460                 1465                 1470             


Cys Lys  Ser Leu Glu Glu Lys  Leu Lys Glu Lys Glu  Ser Ala Leu 
    1475                 1480                 1485             


Arg Leu  Ala Glu Gln Asn Ile  Leu Ser Arg Asp Lys  Val Ile Asn 
    1490                 1495                 1500             


Glu Leu  Arg Leu Arg Leu Pro  Ala Thr Ala Glu Arg  Glu Lys Leu 
    1505                 1510                 1515             


Ile Ala  Glu Leu Gly Arg Lys  Glu Met Glu Pro Lys  Ser His His 
    1520                 1525                 1530             


Thr Leu  Lys Ile Ala His Gln  Thr Ile Ala Asn Met  Gln Ala Arg 
    1535                 1540                 1545             


Leu Asn  Gln Lys Glu Glu Val  Leu Lys Lys Tyr Gln  Arg Leu Leu 
    1550                 1555                 1560             


Glu Lys  Ala Arg Glu Glu Gln  Arg Glu Ile Val Lys  Lys His Glu 
    1565                 1570                 1575             


Glu Asp  Leu His Ile Leu His  His Arg Leu Glu Leu  Gln Ala Asp 
    1580                 1585                 1590             


Ser Ser  Leu Asn Lys Phe Lys  Gln Thr Ala Trp Asp  Leu Met Lys 
    1595                 1600                 1605             


Gln Ser  Pro Thr Pro Val Pro  Thr Asn Lys His Phe  Ile Arg Leu 
    1610                 1615                 1620             


Ala Glu  Met Glu Gln Thr Val  Ala Glu Gln Asp Asp  Ser Leu Ser 
    1625                 1630                 1635             


Ser Leu  Leu Val Lys Leu Lys  Lys Val Ser Gln Asp  Leu Glu Arg 
    1640                 1645                 1650             


Gln Arg  Glu Ile Thr Glu Leu  Lys Val Lys Glu Phe  Glu Asn Ile 
    1655                 1660                 1665             


Lys Leu  Gln Leu Gln Glu Asn  His Glu Asp Glu Val  Lys Lys Val 
    1670                 1675                 1680             


Lys Ala  Glu Val Glu Asp Leu  Lys Tyr Leu Leu Asp  Gln Ser Gln 
    1685                 1690                 1695             


Lys Glu  Ser Gln Cys Leu Lys  Ser Glu Leu Gln Ala  Gln Lys Glu 
    1700                 1705                 1710             


Ala Asn  Ser Arg Ala Pro Thr  Thr Thr Met Arg Asn  Leu Val Glu 
    1715                 1720                 1725             


Arg Leu  Lys Ser Gln Leu Ala  Leu Lys Glu Lys Gln  Gln Lys Ala 
    1730                 1735                 1740             


Leu Ser  Arg Ala Leu Leu Glu  Leu Arg Ala Glu Met  Thr Ala Ala 
    1745                 1750                 1755             


Ala Glu  Glu Arg Ile Ile Ser  Ala Thr Ser Gln Lys  Glu Ala His 
    1760                 1765                 1770             


Leu Asn  Val Gln Gln Ile Val  Asp Arg His Thr Arg  Glu Leu Lys 
    1775                 1780                 1785             


Thr Gln  Val Glu Asp Leu Asn  Glu Asn Leu Leu Lys  Leu Lys Glu 
    1790                 1795                 1800             


Ala Leu  Lys Thr Ser Lys Asn  Arg Glu Asn Ser Leu  Thr Asp Asn 
    1805                 1810                 1815             


Leu Asn  Asp Leu Asn Asn Glu  Leu Gln Lys Lys Gln  Lys Ala Tyr 
    1820                 1825                 1830             


Asn Lys  Ile Leu Arg Glu Lys  Glu Glu Ile Asp Gln  Glu Asn Asp 
    1835                 1840                 1845             


Glu Leu  Lys Arg Gln Ile Lys  Arg Leu Thr Ser Gly  Leu Gln Gly 
    1850                 1855                 1860             


Lys Pro  Leu Thr Asp Asn Lys  Gln Ser Leu Ile Glu  Glu Leu Gln 
    1865                 1870                 1875             


Arg Lys  Val Lys Lys Leu Glu  Asn Gln Leu Glu Gly  Lys Val Glu 
    1880                 1885                 1890             


Glu Val  Asp Leu Lys Pro Met  Lys Glu Lys Asn Ala  Lys Glu Glu 
    1895                 1900                 1905             


Leu Ile  Arg Trp Glu Glu Gly  Lys Lys Trp Gln Ala  Lys Ile Glu 
    1910                 1915                 1920             


Gly Ile  Arg Asn Lys Leu Lys  Glu Lys Glu Gly Glu  Val Phe Thr 
    1925                 1930                 1935             


Leu Thr  Lys Gln Leu Asn Thr  Leu Lys Asp Leu Phe  Ala Lys Ala 
    1940                 1945                 1950             


Asp Lys  Glu Lys Leu Thr Leu  Gln Arg Lys Leu Lys  Thr Thr Gly 
    1955                 1960                 1965             


Met Thr  Val Asp Gln Val Leu  Gly Ile Arg Ala Leu  Glu Ser Glu 
    1970                 1975                 1980             


Lys Glu  Leu Glu Glu Leu Lys  Lys Arg Asn Leu Asp  Leu Glu Asn 
    1985                 1990                 1995             


Asp Ile  Leu Tyr Met Arg Ala  His Gln Ala Leu Pro  Arg Asp Ser 
    2000                 2005                 2010             


Val Val  Glu Asp Leu His Leu  Gln Asn Arg Tyr Leu  Gln Glu Lys 
    2015                 2020                 2025             


Leu His  Ala Leu Glu Lys Gln  Phe Ser Lys Asp Thr  Tyr Ser Lys 
    2030                 2035                 2040             


Pro Ser  Ile Ser Gly Ile Glu  Ser Asp Asp His Cys  Gln Arg Glu 
    2045                 2050                 2055             


Gln Glu  Leu Gln Lys Glu Asn  Leu Lys Leu Ser Ser  Glu Asn Ile 
    2060                 2065                 2070             


Glu Leu  Lys Phe Gln Leu Glu  Gln Ala Asn Lys Asp  Leu Pro Arg 
    2075                 2080                 2085             


Leu Lys  Asn Gln Val Arg Asp  Leu Lys Glu Met Cys  Glu Phe Leu 
    2090                 2095                 2100             


Lys Lys  Glu Lys Ala Glu Val  Gln Arg Lys Leu Gly  His Val Arg 
    2105                 2110                 2115             


Gly Ser  Gly Arg Ser Gly Lys  Thr Ile Pro Glu Leu  Glu Lys Thr 
    2120                 2125                 2130             


Ile Gly  Leu Met Lys Lys Val  Val Glu Lys Val Gln  Arg Glu Asn 
    2135                 2140                 2145             


Glu Gln  Leu Lys Lys Ala Ser  Gly Ile Leu Thr Ser  Glu Lys Met 
    2150                 2155                 2160             


Ala Asn  Ile Glu Gln Glu Asn  Glu Lys Leu Lys Ala  Glu Leu Glu 
    2165                 2170                 2175             


Lys Leu  Lys Ala His Leu Gly  His Gln Leu Ser Met  His Tyr Glu 
    2180                 2185                 2190             


Ser Lys  Thr Lys Gly Thr Glu  Lys Ile Ile Ala Glu  Asn Glu Arg 
    2195                 2200                 2205             


Leu Arg  Lys Glu Leu Lys Lys  Glu Thr Asp Ala Ala  Glu Lys Leu 
    2210                 2215                 2220             


Arg Ile  Ala Lys Asn Asn Leu  Glu Ile Leu Asn Glu  Lys Met Thr 
    2225                 2230                 2235             


Val Gln  Leu Glu Glu Thr Gly  Lys Arg Leu Gln Phe  Ala Glu Ser 
    2240                 2245                 2250             


Arg Gly  Pro Gln Leu Glu Gly  Ala Asp Ser Lys Ser  Trp Lys Ser 
    2255                 2260                 2265             


Ile Val  Val Thr Arg Met Tyr  Glu Thr Lys Leu Lys  Glu Leu Glu 
    2270                 2275                 2280             


Thr Asp  Ile Ala Lys Lys Asn  Gln Ser Ile Thr Asp  Leu Lys Gln 
    2285                 2290                 2295             


Leu Val  Lys Glu Ala Thr Glu  Arg Glu Gln Lys Val  Asn Lys Tyr 
    2300                 2305                 2310             


Asn Glu  Asp Leu Glu Gln Gln  Ile Lys Ile Leu Lys  His Val Pro 
    2315                 2320                 2325             


Glu Gly  Ala Glu Thr Glu Gln  Gly Leu Lys Arg Glu  Leu Gln Val 
    2330                 2335                 2340             


Leu Arg  Leu Ala Asn His Gln  Leu Asp Lys Glu Lys  Ala Glu Leu 
    2345                 2350                 2355             


Ile His  Gln Ile Glu Ala Asn  Lys Asp Gln Ser Gly  Ala Glu Ser 
    2360                 2365                 2370             


Thr Ile  Pro Asp Ala Asp Gln  Leu Lys Glu Lys Ile  Lys Asp Leu 
    2375                 2380                 2385             


Glu Thr  Gln Leu Lys Met Ser  Asp Leu Glu Lys Gln  His Leu Lys 
    2390                 2395                 2400             


Glu Glu  Ile Lys Lys Leu Lys  Lys Glu Leu Glu Asn  Phe Asp Pro 
    2405                 2410                 2415             


Ser Phe  Phe Glu Glu Ile Glu  Asp Leu Lys Tyr Asn  Tyr Lys Glu 
    2420                 2425                 2430             


Glu Val  Lys Lys Asn Ile Leu  Leu Glu Glu Lys Val  Lys Lys Leu 
    2435                 2440                 2445             


Ser Glu  Gln Leu Gly Val Glu  Leu Thr Ser Pro Val  Ala Ala Ser 
    2450                 2455                 2460             


Glu Glu  Phe Glu Asp Glu Glu  Glu Ser Pro Val Asn  Phe Pro Ile 
    2465                 2470                 2475             


Tyr 
    


<210>  27
<211>  1629
<212>  DNA
<213>  Homo sapiens

<400>  27
atgcctctgc gggatgaaac cctccgagag gtgtgggcct ctgacagtgg gcatgaagaa       60

gaaagcctga gcccggaggc cccgcggcgc cccaaacagc gacccgcccc ggcacagagg      120

ctaaggaaga agaggacgga ggcccccgaa tccccctgcc ccacgggatc caagccccgg      180

aagcccggag ctgggcggac ggggaggccg cgggaggagc cttccccaga cccagcccag      240

gcccgggcgc cgcagacggt ctacgccagg ttcctcaggg accccgaggc caagaagcgc      300

gacccccggg aaacctttct ggtagcccgt gccccagacg cggaggacga ggaggaggag      360

gaagaggagg acgaggagga cgaggaagag gaggcagagg aaaagaaaga gaaaatcctt      420

ctgcctccca agaagcccct gagagagaag agctccgcag acctgaagga gaggagggcc      480

aaggcccagg gcccaagggg agacctggga agccctgacc ccccaccgaa acctctgcgt      540

gttaggaata aggaagctcc agcaggggag gggaccaaga tgagaaagac caagaagaaa      600

gggtctgggg aggccgacaa ggacccctca gggagcccag ccagtgcgag gaagagccca      660

gcagccatgt ttctggttgg ggaaggcagt cctgacaaga aagccctgaa gaagaaaggc      720

actcccaaag gcgcgaggaa ggaggaagaa gaggaggagg aggcagctac ggtgataaag      780

aagagcaatc aaaagggcaa agccaaagga aaaggcaaaa agaaagcgaa ggaggagagg      840

gccccgtctc cccccgtgga ggtggacgaa ccccgggagt ttgtgctccg gcctgccccc      900

cagggccgca cggtgcgctg ccggctgacc cgggacaaaa agggcatgga tcgaggcatg      960

tatccctcct acttcctgca cctggacacg gagaagaagg tgttcctctt ggctggcagg     1020

aaacgaaaac ggagcaagac agccaattac ctcatctcca tcgaccctac caatctgtcc     1080

cgaggagggg agaatttcat cgggaagctg aggtccaacc tcctggggaa ccgcttcacg     1140

gtctttgaca acgggcagaa cccacagcgt gggtacagca ctaatgtggc aagccttcgg     1200

caggagctgg cagctgtgat ctatgaaacc aacgtgctgg gcttccgtgg cccccggcgc     1260

atgaccgtca tcattcctgg catgagtgcg gagaacgaga gggtccccat ccggccccga     1320

aatgctagtg acggcctgct ggtgcgctgg cagaacaaga cgctggagag cctcatagaa     1380

ctgcacaaca agccacctgt ctggaacgat gacagtggct cctacaccct caacttccaa     1440

ggccgggtca cccaggcctc agtcaagaac ttccagattg tccacgctga tgaccccgac     1500

tatatcgtgc tgcagttcgg ccgcgtggcg gaggacgcct tcaccctaga ctaccggtac     1560

ccgctgtgcg ccctgcaggc cttcgccatc gccctctcca gtttcgacgg gaagctggcc     1620

tgcgagtga                                                             1629


<210>  28
<211>  542
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Pro Leu Arg Asp Glu Thr Leu Arg Glu Val Trp Ala Ser Asp Ser 
1               5                   10                  15      


Gly His Glu Glu Glu Ser Leu Ser Pro Glu Ala Pro Arg Arg Pro Lys 
            20                  25                  30          


Gln Arg Pro Ala Pro Ala Gln Arg Leu Arg Lys Lys Arg Thr Glu Ala 
        35                  40                  45              


Pro Glu Ser Pro Cys Pro Thr Gly Ser Lys Pro Arg Lys Pro Gly Ala 
    50                  55                  60                  


Gly Arg Thr Gly Arg Pro Arg Glu Glu Pro Ser Pro Asp Pro Ala Gln 
65                  70                  75                  80  


Ala Arg Ala Pro Gln Thr Val Tyr Ala Arg Phe Leu Arg Asp Pro Glu 
                85                  90                  95      


Ala Lys Lys Arg Asp Pro Arg Glu Thr Phe Leu Val Ala Arg Ala Pro 
            100                 105                 110         


Asp Ala Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu 
        115                 120                 125             


Glu Glu Glu Ala Glu Glu Lys Lys Glu Lys Ile Leu Leu Pro Pro Lys 
    130                 135                 140                 


Lys Pro Leu Arg Glu Lys Ser Ser Ala Asp Leu Lys Glu Arg Arg Ala 
145                 150                 155                 160 


Lys Ala Gln Gly Pro Arg Gly Asp Leu Gly Ser Pro Asp Pro Pro Pro 
                165                 170                 175     


Lys Pro Leu Arg Val Arg Asn Lys Glu Ala Pro Ala Gly Glu Gly Thr 
            180                 185                 190         


Lys Met Arg Lys Thr Lys Lys Lys Gly Ser Gly Glu Ala Asp Lys Asp 
        195                 200                 205             


Pro Ser Gly Ser Pro Ala Ser Ala Arg Lys Ser Pro Ala Ala Met Phe 
    210                 215                 220                 


Leu Val Gly Glu Gly Ser Pro Asp Lys Lys Ala Leu Lys Lys Lys Gly 
225                 230                 235                 240 


Thr Pro Lys Gly Ala Arg Lys Glu Glu Glu Glu Glu Glu Glu Ala Ala 
                245                 250                 255     


Thr Val Ile Lys Lys Ser Asn Gln Lys Gly Lys Ala Lys Gly Lys Gly 
            260                 265                 270         


Lys Lys Lys Ala Lys Glu Glu Arg Ala Pro Ser Pro Pro Val Glu Val 
        275                 280                 285             


Asp Glu Pro Arg Glu Phe Val Leu Arg Pro Ala Pro Gln Gly Arg Thr 
    290                 295                 300                 


Val Arg Cys Arg Leu Thr Arg Asp Lys Lys Gly Met Asp Arg Gly Met 
305                 310                 315                 320 


Tyr Pro Ser Tyr Phe Leu His Leu Asp Thr Glu Lys Lys Val Phe Leu 
                325                 330                 335     


Leu Ala Gly Arg Lys Arg Lys Arg Ser Lys Thr Ala Asn Tyr Leu Ile 
            340                 345                 350         


Ser Ile Asp Pro Thr Asn Leu Ser Arg Gly Gly Glu Asn Phe Ile Gly 
        355                 360                 365             


Lys Leu Arg Ser Asn Leu Leu Gly Asn Arg Phe Thr Val Phe Asp Asn 
    370                 375                 380                 


Gly Gln Asn Pro Gln Arg Gly Tyr Ser Thr Asn Val Ala Ser Leu Arg 
385                 390                 395                 400 


Gln Glu Leu Ala Ala Val Ile Tyr Glu Thr Asn Val Leu Gly Phe Arg 
                405                 410                 415     


Gly Pro Arg Arg Met Thr Val Ile Ile Pro Gly Met Ser Ala Glu Asn 
            420                 425                 430         


Glu Arg Val Pro Ile Arg Pro Arg Asn Ala Ser Asp Gly Leu Leu Val 
        435                 440                 445             


Arg Trp Gln Asn Lys Thr Leu Glu Ser Leu Ile Glu Leu His Asn Lys 
    450                 455                 460                 


Pro Pro Val Trp Asn Asp Asp Ser Gly Ser Tyr Thr Leu Asn Phe Gln 
465                 470                 475                 480 


Gly Arg Val Thr Gln Ala Ser Val Lys Asn Phe Gln Ile Val His Ala 
                485                 490                 495     


Asp Asp Pro Asp Tyr Ile Val Leu Gln Phe Gly Arg Val Ala Glu Asp 
            500                 505                 510         


Ala Phe Thr Leu Asp Tyr Arg Tyr Pro Leu Cys Ala Leu Gln Ala Phe 
        515                 520                 525             


Ala Ile Ala Leu Ser Ser Phe Asp Gly Lys Leu Ala Cys Glu 
    530                 535                 540         


<210>  29
<211>  900
<212>  DNA
<213>  Homo sapiens

<400>  29
atgatggcgt atatgaaccc ggggccccac tattctgtca acgccttggc cctaagtggc       60

cccagtgtgg atctgatgca ccaggctgtg ccctacccaa gcgcccccag gaagcagcgg      120

cgggagcgca ccaccttcac ccggagccaa ctggaggagc tggaggcact gtttgccaag      180

acccagtacc cagacgtcta tgcccgtgag gaggtggctc tgaagatcaa tctgcctgag      240

tccagggttc aggtttggtt caagaaccgg agggctaaat gcaggcagca gcgacagcag      300

cagaaacagc agcagcagcc cccagggggc caggccaagg cccggcctgc caagaggaag      360

gcgggcacgt ccccaagacc ctccacagat gtgtgtccag accctctggg catctcagat      420

tcctacagtc cccctctgcc cggcccctca ggctccccaa ccacggcagt ggccactgtg      480

tccatctgga gcccagcctc agagtcccct ttgcctgagg cgcagcgggc tgggctggtg      540

gcctcagggc cgtctctgac ctccgccccc tatgccatga cctacgcccc ggcctccgct      600

ttctgctctt ccccctccgc ctatgggtct ccgagctcct atttcagcgg cctagacccc      660

tacctttctc ccatggtgcc ccagctaggg ggcccggctc ttagccccct ctctggcccc      720

tccgtgggac cttccctggc ccagtccccc acctccctat caggccagag ctatggcgcc      780

tacagccccg tggatagctt ggaattcaag gaccccacgg gcacctggaa attcacctac      840

aatcccatgg accctctgga ctacaaggat cagagtgcct ggaagtttca gatcttgtag      900


<210>  30
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Met Ala Tyr Met Asn Pro Gly Pro His Tyr Ser Val Asn Ala Leu 
1               5                   10                  15      


Ala Leu Ser Gly Pro Ser Val Asp Leu Met His Gln Ala Val Pro Tyr 
            20                  25                  30          


Pro Ser Ala Pro Arg Lys Gln Arg Arg Glu Arg Thr Thr Phe Thr Arg 
        35                  40                  45              


Ser Gln Leu Glu Glu Leu Glu Ala Leu Phe Ala Lys Thr Gln Tyr Pro 
    50                  55                  60                  


Asp Val Tyr Ala Arg Glu Glu Val Ala Leu Lys Ile Asn Leu Pro Glu 
65                  70                  75                  80  


Ser Arg Val Gln Val Trp Phe Lys Asn Arg Arg Ala Lys Cys Arg Gln 
                85                  90                  95      


Gln Arg Gln Gln Gln Lys Gln Gln Gln Gln Pro Pro Gly Gly Gln Ala 
            100                 105                 110         


Lys Ala Arg Pro Ala Lys Arg Lys Ala Gly Thr Ser Pro Arg Pro Ser 
        115                 120                 125             


Thr Asp Val Cys Pro Asp Pro Leu Gly Ile Ser Asp Ser Tyr Ser Pro 
    130                 135                 140                 


Pro Leu Pro Gly Pro Ser Gly Ser Pro Thr Thr Ala Val Ala Thr Val 
145                 150                 155                 160 


Ser Ile Trp Ser Pro Ala Ser Glu Ser Pro Leu Pro Glu Ala Gln Arg 
                165                 170                 175     


Ala Gly Leu Val Ala Ser Gly Pro Ser Leu Thr Ser Ala Pro Tyr Ala 
            180                 185                 190         


Met Thr Tyr Ala Pro Ala Ser Ala Phe Cys Ser Ser Pro Ser Ala Tyr 
        195                 200                 205             


Gly Ser Pro Ser Ser Tyr Phe Ser Gly Leu Asp Pro Tyr Leu Ser Pro 
    210                 215                 220                 


Met Val Pro Gln Leu Gly Gly Pro Ala Leu Ser Pro Leu Ser Gly Pro 
225                 230                 235                 240 


Ser Val Gly Pro Ser Leu Ala Gln Ser Pro Thr Ser Leu Ser Gly Gln 
                245                 250                 255     


Ser Tyr Gly Ala Tyr Ser Pro Val Asp Ser Leu Glu Phe Lys Asp Pro 
            260                 265                 270         


Thr Gly Thr Trp Lys Phe Thr Tyr Asn Pro Met Asp Pro Leu Asp Tyr 
        275                 280                 285             


Lys Asp Gln Ser Ala Trp Lys Phe Gln Ile Leu 
    290                 295                 


<210>  31
<211>  1155
<212>  DNA
<213>  Homo sapiens

<400>  31
atggatgccg ctctgctcct gaacgtggaa ggggtcaaga aaaccattct gcacgggggc       60

acgggcgagc tcccaaactt catcaccgga tcccgagtga tctttcattt ccgcaccatg      120

aaatgtgatg aggagcggac agtcattgac gacagtcggc aggtgggcca gcccatgcac      180

atcatcatcg gaaacatgtt caagctcgag gtctgggaga tcctgcttac ctccatgcgg      240

gtgcacgagg tggccgagtt ctggtgcgac accatccaca cgggggtcta ccccatccta      300

tcccggagcc tgaggcagat ggcccagggc aaggacccca cagagtggca cgtgcacacg      360

tgcgggctgg ccaacatgtt cgcctaccac acgctgggct acgaggacct ggacgagctg      420

cagaaggagc ctcagcctct ggtctttgtg atcgagctgc tgcaggttga tgccccgagt      480

gattaccaga gggagacctg gaacctgagc aatcatgaga agatgaaggc ggtgcccgtc      540

ctccacggag agggaaatcg gctcttcaag ctgggccgct acgaggaggc ctcttccaag      600

taccaggagg ccatcatctg cctaaggaac ctgcagacca aggagaagcc atgggaggtg      660

cagtggctga agctggagaa gatgatcaat actctgatcc tcaactactg ccagtgcctg      720

ctgaagaagg aggagtacta tgaggtgctg gagcacacca gtgatattct ccggcaccac      780

ccaggcatcg tgaaggccta ctacgtgcgt gcccgggctc acgcagaggt gtggaatgag      840

gccgaggcca aggcggacct ccagaaagtg ctggagctgg agccgtccat gcagaaggcg      900

gtgcgcaggg agctgaggct gctggagaac cgcatggcgg agaagcagga ggaggagcgg      960

ctgcgctgcc ggaacatgct gagccagggt gccacgcagc ctcccgcaga gccacccaca     1020

gagccacccg cacagtcatc cacagagcca cctgcagagc cacccacagc accatctgca     1080

gagctgtccg cagggccccc tgcagagcca gccacagagc cacccccgtc cccagggcac     1140

tcgctgcagc actga                                                      1155


<210>  32
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Asp Ala Ala Leu Leu Leu Asn Val Glu Gly Val Lys Lys Thr Ile 
1               5                   10                  15      


Leu His Gly Gly Thr Gly Glu Leu Pro Asn Phe Ile Thr Gly Ser Arg 
            20                  25                  30          


Val Ile Phe His Phe Arg Thr Met Lys Cys Asp Glu Glu Arg Thr Val 
        35                  40                  45              


Ile Asp Asp Ser Arg Gln Val Gly Gln Pro Met His Ile Ile Ile Gly 
    50                  55                  60                  


Asn Met Phe Lys Leu Glu Val Trp Glu Ile Leu Leu Thr Ser Met Arg 
65                  70                  75                  80  


Val His Glu Val Ala Glu Phe Trp Cys Asp Thr Ile His Thr Gly Val 
                85                  90                  95      


Tyr Pro Ile Leu Ser Arg Ser Leu Arg Gln Met Ala Gln Gly Lys Asp 
            100                 105                 110         


Pro Thr Glu Trp His Val His Thr Cys Gly Leu Ala Asn Met Phe Ala 
        115                 120                 125             


Tyr His Thr Leu Gly Tyr Glu Asp Leu Asp Glu Leu Gln Lys Glu Pro 
    130                 135                 140                 


Gln Pro Leu Val Phe Val Ile Glu Leu Leu Gln Val Asp Ala Pro Ser 
145                 150                 155                 160 


Asp Tyr Gln Arg Glu Thr Trp Asn Leu Ser Asn His Glu Lys Met Lys 
                165                 170                 175     


Ala Val Pro Val Leu His Gly Glu Gly Asn Arg Leu Phe Lys Leu Gly 
            180                 185                 190         


Arg Tyr Glu Glu Ala Ser Ser Lys Tyr Gln Glu Ala Ile Ile Cys Leu 
        195                 200                 205             


Arg Asn Leu Gln Thr Lys Glu Lys Pro Trp Glu Val Gln Trp Leu Lys 
    210                 215                 220                 


Leu Glu Lys Met Ile Asn Thr Leu Ile Leu Asn Tyr Cys Gln Cys Leu 
225                 230                 235                 240 


Leu Lys Lys Glu Glu Tyr Tyr Glu Val Leu Glu His Thr Ser Asp Ile 
                245                 250                 255     


Leu Arg His His Pro Gly Ile Val Lys Ala Tyr Tyr Val Arg Ala Arg 
            260                 265                 270         


Ala His Ala Glu Val Trp Asn Glu Ala Glu Ala Lys Ala Asp Leu Gln 
        275                 280                 285             


Lys Val Leu Glu Leu Glu Pro Ser Met Gln Lys Ala Val Arg Arg Glu 
    290                 295                 300                 


Leu Arg Leu Leu Glu Asn Arg Met Ala Glu Lys Gln Glu Glu Glu Arg 
305                 310                 315                 320 


Leu Arg Cys Arg Asn Met Leu Ser Gln Gly Ala Thr Gln Pro Pro Ala 
                325                 330                 335     


Glu Pro Pro Thr Glu Pro Pro Ala Gln Ser Ser Thr Glu Pro Pro Ala 
            340                 345                 350         


Glu Pro Pro Thr Ala Pro Ser Ala Glu Leu Ser Ala Gly Pro Pro Ala 
        355                 360                 365             


Glu Pro Ala Thr Glu Pro Pro Pro Ser Pro Gly His Ser Leu Gln His 
    370                 375                 380                 


<210>  33
<211>  828
<212>  DNA
<213>  Homo sapiens

<400>  33
atgaccacag agcaggcaag ggggcagcag ggcccaaatc tggccattgg ccgtcagaag       60

ccccctgcgg gggttgtgac tcccaagagt gatgcagagg agcccccgtt gaccaggaag      120

aggagcaaga aggagagggg gctccgaggg tctcgaaagc gcactggcag ctctggggag      180

cagacaggcc ccgaggcccc ggggagcagc aataaccctc ccagcactgg agaggggccg      240

gcgggcgcac cccctgcatc ccctgggccg gcctcttctc gccagtccca ccgacatcgt      300

cctgactccc tgcacgacgc tgctcagagg acatacgggc ccctgctcaa tcgagtcttc      360

gggaaggacc gcgaactggg ccccgaggag ctagacgagc ttcaggccgc cttcgaggag      420

tttgacactg accgtgacgg ctacatcagc caccgggagc tgggtgactg catgcggacc      480

ctgggctaca tgcccaccga gatggagctc ctggaggtct cgcagcacat caagatgcgc      540

atgggcggcc gtgtggactt tgaggagttt gtagaactga taggcccaaa gctgagggag      600

gagacggcgc acatgctggg ggtgcgagag ctgcgcatcg ccttccgaga gtttgacagg      660

gacagggatg gacgaattac ggtggcggag ctgcgggagg cggtaccggc tctgctcggg      720

gagccgctgg cgggtcctga gctggacgag atgctccgag aagtggacct caatggggat      780

ggcaccgtag actttgacga gtttgtgatg atgctctccc gccactga                   828


<210>  34
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Thr Thr Glu Gln Ala Arg Gly Gln Gln Gly Pro Asn Leu Ala Ile 
1               5                   10                  15      


Gly Arg Gln Lys Pro Pro Ala Gly Val Val Thr Pro Lys Ser Asp Ala 
            20                  25                  30          


Glu Glu Pro Pro Leu Thr Arg Lys Arg Ser Lys Lys Glu Arg Gly Leu 
        35                  40                  45              


Arg Gly Ser Arg Lys Arg Thr Gly Ser Ser Gly Glu Gln Thr Gly Pro 
    50                  55                  60                  


Glu Ala Pro Gly Ser Ser Asn Asn Pro Pro Ser Thr Gly Glu Gly Pro 
65                  70                  75                  80  


Ala Gly Ala Pro Pro Ala Ser Pro Gly Pro Ala Ser Ser Arg Gln Ser 
                85                  90                  95      


His Arg His Arg Pro Asp Ser Leu His Asp Ala Ala Gln Arg Thr Tyr 
            100                 105                 110         


Gly Pro Leu Leu Asn Arg Val Phe Gly Lys Asp Arg Glu Leu Gly Pro 
        115                 120                 125             


Glu Glu Leu Asp Glu Leu Gln Ala Ala Phe Glu Glu Phe Asp Thr Asp 
    130                 135                 140                 


Arg Asp Gly Tyr Ile Ser His Arg Glu Leu Gly Asp Cys Met Arg Thr 
145                 150                 155                 160 


Leu Gly Tyr Met Pro Thr Glu Met Glu Leu Leu Glu Val Ser Gln His 
                165                 170                 175     


Ile Lys Met Arg Met Gly Gly Arg Val Asp Phe Glu Glu Phe Val Glu 
            180                 185                 190         


Leu Ile Gly Pro Lys Leu Arg Glu Glu Thr Ala His Met Leu Gly Val 
        195                 200                 205             


Arg Glu Leu Arg Ile Ala Phe Arg Glu Phe Asp Arg Asp Arg Asp Gly 
    210                 215                 220                 


Arg Ile Thr Val Ala Glu Leu Arg Glu Ala Val Pro Ala Leu Leu Gly 
225                 230                 235                 240 


Glu Pro Leu Ala Gly Pro Glu Leu Asp Glu Met Leu Arg Glu Val Asp 
                245                 250                 255     


Leu Asn Gly Asp Gly Thr Val Asp Phe Asp Glu Phe Val Met Met Leu 
            260                 265                 270         


Ser Arg His 
        275 


<210>  35
<211>  714
<212>  DNA
<213>  Homo sapiens

<400>  35
atggccctgc cccccagccc cctggccatg gaatatgtca atgactttga cttgatgaag       60

tttgaggtaa agcgggaacc ctctgagggc cgacctggcc cccctacagc ctcactgggc      120

tccacacctt acagctcagt gcctccttca cccaccttca gtgaaccagg catggtgggg      180

gcaaccgagg gcacccggcc aggcctggag gagctgtact ggctggctac cctgcagcag      240

cagctggggg ctggggaggc attggggctg agtcctgaag aggccatgga gctgctgcag      300

ggtcagggcc cagtccctgt tgatgggccc catggctact acccagggag cccagaggag      360

acaggagccc agcacgtcca gctggcagag cggttttccg acgcggcgct ggtctcgatg      420

tctgtgcggg agctaaaccg gcagctgcgg ggctgcgggc gcgacgaggc gctgcggctg      480

aagcagaggc gccgcacgct gaagaaccgc ggctacgcgc aggcctgtcg ctccaagcgg      540

ctgcagcagc ggcgcgggct ggaggccgag cgcgcccgcc tggccgccca gctggacgcg      600

ctgcgggccg aggtggcccg cctggcccgg gagcgcgatc tctacaaggc tcgctgtgac      660

cggctaacct cgagcggccc cgggtccggg gacccctccc acctcttcct ctga            714


<210>  36
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Leu Pro Pro Ser Pro Leu Ala Met Glu Tyr Val Asn Asp Phe 
1               5                   10                  15      


Asp Leu Met Lys Phe Glu Val Lys Arg Glu Pro Ser Glu Gly Arg Pro 
            20                  25                  30          


Gly Pro Pro Thr Ala Ser Leu Gly Ser Thr Pro Tyr Ser Ser Val Pro 
        35                  40                  45              


Pro Ser Pro Thr Phe Ser Glu Pro Gly Met Val Gly Ala Thr Glu Gly 
    50                  55                  60                  


Thr Arg Pro Gly Leu Glu Glu Leu Tyr Trp Leu Ala Thr Leu Gln Gln 
65                  70                  75                  80  


Gln Leu Gly Ala Gly Glu Ala Leu Gly Leu Ser Pro Glu Glu Ala Met 
                85                  90                  95      


Glu Leu Leu Gln Gly Gln Gly Pro Val Pro Val Asp Gly Pro His Gly 
            100                 105                 110         


Tyr Tyr Pro Gly Ser Pro Glu Glu Thr Gly Ala Gln His Val Gln Leu 
        115                 120                 125             


Ala Glu Arg Phe Ser Asp Ala Ala Leu Val Ser Met Ser Val Arg Glu 
    130                 135                 140                 


Leu Asn Arg Gln Leu Arg Gly Cys Gly Arg Asp Glu Ala Leu Arg Leu 
145                 150                 155                 160 


Lys Gln Arg Arg Arg Thr Leu Lys Asn Arg Gly Tyr Ala Gln Ala Cys 
                165                 170                 175     


Arg Ser Lys Arg Leu Gln Gln Arg Arg Gly Leu Glu Ala Glu Arg Ala 
            180                 185                 190         


Arg Leu Ala Ala Gln Leu Asp Ala Leu Arg Ala Glu Val Ala Arg Leu 
        195                 200                 205             


Ala Arg Glu Arg Asp Leu Tyr Lys Ala Arg Cys Asp Arg Leu Thr Ser 
    210                 215                 220                 


Ser Gly Pro Gly Ser Gly Asp Pro Ser His Leu Phe Leu 
225                 230                 235         


<210>  37
<211>  1041
<212>  DNA
<213>  Homo sapiens

<400>  37
atggcgctac tgaaagtcaa gtttgaccag aagaagcggg tcaagttggc ccaagggctc       60

tggctcatga actggttctc cgtgttggct ggcatcatca tcttcagcct aggactgttc      120

ctgaagattg aactccgaaa gaggagcgat gtgatgaata attctgagag ccattttgtg      180

cccaactcat tgatagggat gggggtgcta tcctgtgtct tcaactcgct ggctgggaag      240

atctgctacg acgccctgga cccagccaag tatgccagat ggaagccctg gctgaagccg      300

tacctggcta tctgtgttct cttcaacatc atcctcttcc ttgtggctct ctgctgcttt      360

ctgcttcggg gctcgctgga gaacaccctg ggccaagggc tcaagaacgg catgaagtac      420

taccgggaca cagacacccc tggcaggtgt ttcatgaaga agaccatcga catgctgcag      480

atcgagttca aatgctgcgg caacaacggt tttcgggact ggtttgagat tcagtggatc      540

agcaatcgct acctggactt ttcctccaaa gaagtcaaag atcgaatcaa gagcaacgtg      600

gatgggcggt acctggtgga cggcgtccct ttcagctgct gcaatcctag ctcgccacgg      660

ccctgcatcc agtatcagat caccaacaac tcagcacact acagttacga ccaccagacg      720

gaggagctca acctgtgggt gcgtggctgc agggctgccc tgctgagcta ctacagcagc      780

ctcatgaact ccatgggtgt cgtcacgctc ctcatttggc tcttcgaggt gaccattaca      840

attgggctgc gctacctaca gacgtcgctg gatggtgtgt ccaaccccga ggaatctgag      900

agcgagagcc agggctggct gctggagagg agcgtgccgg agacctggaa ggcctttctg      960

gagagtgtga agaagctggg caagggcaac caggtggaag ccgagggcgc agacgcaggc     1020

caggccccag aggctggctg a                                               1041


<210>  38
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Leu Leu Lys Val Lys Phe Asp Gln Lys Lys Arg Val Lys Leu 
1               5                   10                  15      


Ala Gln Gly Leu Trp Leu Met Asn Trp Phe Ser Val Leu Ala Gly Ile 
            20                  25                  30          


Ile Ile Phe Ser Leu Gly Leu Phe Leu Lys Ile Glu Leu Arg Lys Arg 
        35                  40                  45              


Ser Asp Val Met Asn Asn Ser Glu Ser His Phe Val Pro Asn Ser Leu 
    50                  55                  60                  


Ile Gly Met Gly Val Leu Ser Cys Val Phe Asn Ser Leu Ala Gly Lys 
65                  70                  75                  80  


Ile Cys Tyr Asp Ala Leu Asp Pro Ala Lys Tyr Ala Arg Trp Lys Pro 
                85                  90                  95      


Trp Leu Lys Pro Tyr Leu Ala Ile Cys Val Leu Phe Asn Ile Ile Leu 
            100                 105                 110         


Phe Leu Val Ala Leu Cys Cys Phe Leu Leu Arg Gly Ser Leu Glu Asn 
        115                 120                 125             


Thr Leu Gly Gln Gly Leu Lys Asn Gly Met Lys Tyr Tyr Arg Asp Thr 
    130                 135                 140                 


Asp Thr Pro Gly Arg Cys Phe Met Lys Lys Thr Ile Asp Met Leu Gln 
145                 150                 155                 160 


Ile Glu Phe Lys Cys Cys Gly Asn Asn Gly Phe Arg Asp Trp Phe Glu 
                165                 170                 175     


Ile Gln Trp Ile Ser Asn Arg Tyr Leu Asp Phe Ser Ser Lys Glu Val 
            180                 185                 190         


Lys Asp Arg Ile Lys Ser Asn Val Asp Gly Arg Tyr Leu Val Asp Gly 
        195                 200                 205             


Val Pro Phe Ser Cys Cys Asn Pro Ser Ser Pro Arg Pro Cys Ile Gln 
    210                 215                 220                 


Tyr Gln Ile Thr Asn Asn Ser Ala His Tyr Ser Tyr Asp His Gln Thr 
225                 230                 235                 240 


Glu Glu Leu Asn Leu Trp Val Arg Gly Cys Arg Ala Ala Leu Leu Ser 
                245                 250                 255     


Tyr Tyr Ser Ser Leu Met Asn Ser Met Gly Val Val Thr Leu Leu Ile 
            260                 265                 270         


Trp Leu Phe Glu Val Thr Ile Thr Ile Gly Leu Arg Tyr Leu Gln Thr 
        275                 280                 285             


Ser Leu Asp Gly Val Ser Asn Pro Glu Glu Ser Glu Ser Glu Ser Glu 
    290                 295                 300                 


Gly Trp Leu Leu Glu Lys Ser Val Pro Glu Thr Trp Lys Ala Phe Leu 
305                 310                 315                 320 


Glu Ser Val Lys Lys Leu Gly Lys Gly Asn Gln Val Glu Ala Glu Gly 
                325                 330                 335     


Ala Gly Ala Gly Gln Ala Pro Glu Ala Gly 
            340                 345     


<210>  39
<211>  1047
<212>  DNA
<213>  Homo sapiens

<400>  39
atgaatggca cagaaggccc taacttctac gtgcccttct ccaatgcgac gggtgtggta       60

cgcagcccct tcgagtaccc acagtactac ctggctgagc catggcagtt ctccatgctg      120

gccgcctaca tgtttctgct gatcgtgctg ggcttcccca tcaacttcct cacgctctac      180

gtcaccgtcc agcacaagaa gctgcgcacg cctctcaact acatcctgct caacctagcc      240

gtggctgacc tcttcatggt cctaggtggc ttcaccagca ccctctacac ctctctgcat      300

ggatacttcg tcttcgggcc cacaggatgc aatttggagg gcttctttgc caccctgggc      360

ggtgaaattg ccctgtggtc cttggtggtc ctggccatcg agcggtacgt ggtggtgtgt      420

aagcccatga gcaacttccg cttcggggag aaccatgcca tcatgggcgt tgccttcacc      480

tgggtcatgg cgctggcctg cgccgcaccc ccactcgccg gctggtccag gtacatcccc      540

gagggcctgc agtgctcgtg tggaatcgac tactacacgc tcaagccgga ggtcaacaac      600

gagtcttttg tcatctacat gttcgtggtc cacttcacca tccccatgat tatcatcttt      660

ttctgctatg ggcagctcgt cttcaccgtc aaggaggccg ctgcccagca gcaggagtca      720

gccaccacac agaaggcaga gaaggaggtc acccgcatgg tcatcatcat ggtcatcgct      780

ttcctgatct gctgggtgcc ctacgccagc gtggcattct acatcttcac ccaccagggc      840

tccaacttcg gtcccatctt catgaccatc ccagcgttct ttgccaagag cgccgccatc      900

tacaaccctg tcatctatat catgatgaac aagcagttcc ggaactgcat gctcaccacc      960

atctgctgcg gcaagaaccc actgggtgac gatgaggcct ctgctaccgt gtccaagacg     1020

gagacgagcc aggtggcccc ggcctaa                                         1047


<210>  40
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Asn Gly Thr Glu Gly Pro Asn Phe Tyr Val Pro Phe Ser Asn Ala 
1               5                   10                  15      


Thr Gly Val Val Arg Ser Pro Phe Glu Tyr Pro Gln Tyr Tyr Leu Ala 
            20                  25                  30          


Glu Pro Trp Gln Phe Ser Met Leu Ala Ala Tyr Met Phe Leu Leu Ile 
        35                  40                  45              


Val Leu Gly Phe Pro Ile Asn Phe Leu Thr Leu Tyr Val Thr Val Gln 
    50                  55                  60                  


His Lys Lys Leu Arg Thr Pro Leu Asn Tyr Ile Leu Leu Asn Leu Ala 
65                  70                  75                  80  


Val Ala Asp Leu Phe Met Val Leu Gly Gly Phe Thr Ser Thr Leu Tyr 
                85                  90                  95      


Thr Ser Leu His Gly Tyr Phe Val Phe Gly Pro Thr Gly Cys Asn Leu 
            100                 105                 110         


Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp Ser Leu 
        115                 120                 125             


Val Val Leu Ala Ile Glu Arg Tyr Val Val Val Cys Lys Pro Met Ser 
    130                 135                 140                 


Asn Phe Arg Phe Gly Glu Asn His Ala Ile Met Gly Val Ala Phe Thr 
145                 150                 155                 160 


Trp Val Met Ala Leu Ala Cys Ala Ala Pro Pro Leu Ala Gly Trp Ser 
                165                 170                 175     


Arg Tyr Ile Pro Glu Gly Leu Gln Cys Ser Cys Gly Ile Asp Tyr Tyr 
            180                 185                 190         


Thr Leu Lys Pro Glu Val Asn Asn Glu Ser Phe Val Ile Tyr Met Phe 
        195                 200                 205             


Val Val His Phe Thr Ile Pro Met Ile Ile Ile Phe Phe Cys Tyr Gly 
    210                 215                 220                 


Gln Leu Val Phe Thr Val Lys Glu Ala Ala Ala Gln Gln Gln Glu Ser 
225                 230                 235                 240 


Ala Thr Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Ile Ile 
                245                 250                 255     


Met Val Ile Ala Phe Leu Ile Cys Trp Val Pro Tyr Ala Ser Val Ala 
            260                 265                 270         


Phe Tyr Ile Phe Thr His Gln Gly Ser Asn Phe Gly Pro Ile Phe Met 
        275                 280                 285             


Thr Ile Pro Ala Phe Phe Ala Lys Ser Ala Ala Ile Tyr Asn Pro Val 
    290                 295                 300                 


Ile Tyr Ile Met Met Asn Lys Gln Phe Arg Asn Cys Met Leu Thr Thr 
305                 310                 315                 320 


Ile Cys Cys Gly Lys Asn Pro Leu Gly Asp Asp Glu Ala Ser Ala Thr 
                325                 330                 335     


Val Ser Lys Thr Glu Thr Ser Gln Val Ala Pro Ala 
            340                 345             


<210>  41
<211>  3000
<212>  DNA
<213>  Homo sapiens

<400>  41
atggggccgg ccccgctgcc gctgctgctg ggcctcttcc tccccgcgct ctggcgtaga       60

gctatcactg aggcaaggga agaagccaag ccttacccgc tattcccggg accttttcca      120

gggagcctgc aaactgacca cacaccgctg ttatcccttc ctcacgccag tgggtaccag      180

cctgccttga tgttttcacc aacccagcct ggaagaccac atacaggaaa cgtagccatt      240

ccccaggtga cctctgtcga atcaaagccc ctaccgcctc ttgccttcaa acacacagtt      300

ggacacataa tactttctga acataaaggt gtcaaattta attgctcaat cagtgtacct      360

aatatatacc aggacaccac aatttcttgg tggaaagatg ggaaggaatt gcttggggca      420

catcatgcaa ttacacagtt ttatccagat gatgaagtta cagcaataat cgcttccttc      480

agcataacca gtgtgcagcg ttcagacaat gggtcgtata tctgtaagat gaaaataaac      540

aatgaagaga tcgtgtctga tcccatctac atcgaagtac aaggacttcc tcactttact      600

aagcagcctg agagcatgaa tgtcaccaga aacacagcct tcaacctcac ctgtcaggct      660

gtgggcccgc ctgagcccgt caacattttc tgggttcaaa acagtagccg tgttaacgaa      720

cagcctgaaa aatccccctc cgtgctaact gttccaggcc tgacggagat ggcggtcttc      780

agttgtgagg cccacaatga caaagggctg accgtgtcca agggagtgca gatcaacatc      840

aaagcaattc cctccccacc aactgaagtc agcatccgta acagcactgc acacagcatt      900

ctgatctcct gggttcctgg ttttgatgga tactccccgt tcaggaattg cagcattcag      960

gtcaaggaag ctgatccgct gagtaatggc tcagtcatga tttttaacac ctctgcctta     1020

ccacatctgt accaaatcaa gcagctgcaa gccctggcta attacagcat tggtgtttcc     1080

tgcatgaatg aaataggctg gtctgcagtg agcccttgga ttctagccag cacgactgaa     1140

ggagccccat cagtagcacc tttaaatgtc actgtgtttc tgaatgaatc tagtgataat     1200

gtggacatca gatggatgaa gcctccgact aagcagcagg atggagaact ggtgggctac     1260

cggatatccc acgtgtggca gagtgcaggg atttccaaag agctcttgga ggaagttggc     1320

cagaatggca gccgagctcg gatctctgtt caagtccaca atgctacgtg cacagtgagg     1380

attgcagccg tcaccagagg gggagttggg cccttcagtg atccagtgaa aatatttatc     1440

cctgcacacg gttgggtaga ttatgccccc tcttcaactc cggcgcctgg caacgcagat     1500

cctgtgctca tcatctttgg ctgcttttgt ggatttattt tgattgggtt gattttatac     1560

atctccttgg ccatcagaaa aagagtccag gagacaaagt ttgggaatgc attcacagag     1620

gaggattctg aattagtggt gaattatata gcaaagaaat ccttctgtcg gcgagccatt     1680

gaacttacct tacatagctt gggagtcagt gaggaactac aaaataaact agaagatgtt     1740

gtgattgaca ggaatcttct aattcttgga aaaattctgg gtgaaggaga gtttgggtct     1800

gtaatggaag gaaatcttaa gcaggaagat gggacctctc tgaaagtggc agtgaagacc     1860

atgaagttgg acaactcttc acagcgggag atcgaggagt ttctcagtga ggcagcgtgc     1920

atgaaagact tcagccaccc aaatgtcatt cgacttctag gtgtgtgtat agaaatgagc     1980

tctcaaggca tcccaaagcc catggtaatt ttacccttca tgaaatacgg ggacctgcat     2040

acttacttac tttattcccg attggagaca ggaccaaagc atattcctct gcagacacta     2100

ttgaagttca tggtggatat tgccctggga atggagtatc tgagcaacag gaattttctt     2160

catcgagatt tagctgctcg aaactgcatg ttgcgagatg acatgactgt ctgtgttgcg     2220

gacttcggcc tctctaagaa gatttacagt ggcgattatt accgccaagg ccgcattgct     2280

aagatgcctg ttaaatggat cgccatagaa agtcttgcag accgagtcta cacaagtaaa     2340

agtgatgtgt gggcatttgg cgtgaccatg tgggaaatag ctacgcgggg aatgactccc     2400

tatcctgggg tccagaacca tgagatgtat gactatcttc tccatggcca caggttgaag     2460

cagcccgaag actgcctgga tgaactgtat gaaataatgt actcttgctg gagaaccgat     2520

cccttagacc gccccacctt ttcagtattg aggctgcagc tagaaaaact cttagaaagt     2580

ttgcctgacg ttcggaacca agcagacgtt atttacgtca atacacagtt gctggagagc     2640

tctgagggcc tggcccaggg ctccaccctt gctccactgg acttgaacat cgaccctgac     2700

tctataattg cctcctgcac tccccgcgct gccatcagtg tggtcacagc agaagttcat     2760

gacagcaaac ctcatgaagg acggtacatc ctgaatgggg gcagtgagga atgggaagat     2820

ctgacttctg ccccctctgc tgcagtcaca gctgaaaaga acagtgtttt accgggggag     2880

agacttgtta ggaatggggt ctcctggtcc cattcgagca tgctgccctt gggaagctca     2940

ttgcccgatg aacttttgtt tgctgacgac tcctcagaag gctcagaagt cctgatgtga     3000


<210>  42
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Gly Pro Ala Pro Leu Pro Leu Leu Leu Gly Leu Phe Leu Pro Ala 
1               5                   10                  15      


Leu Trp Arg Arg Ala Ile Thr Glu Ala Arg Glu Glu Ala Lys Pro Tyr 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Phe Pro Gly Ser Leu Gln Thr Asp His Thr 
        35                  40                  45              


Pro Leu Leu Ser Leu Pro His Ala Ser Gly Tyr Gln Met Gly Pro Ala 
    50                  55                  60                  


Pro Leu Pro Leu Leu Leu Gly Leu Phe Leu Pro Ala Leu Trp Arg Arg 
65                  70                  75                  80  


Ala Ile Thr Glu Ala Arg Glu Glu Ala Lys Pro Tyr Pro Leu Phe Pro 
                85                  90                  95      


Gly Pro Phe Pro Gly Ser Leu Gln Thr Asp His Thr Pro Leu Leu Ser 
            100                 105                 110         


Leu Pro His Ala Ser Gly Tyr Gln 
        115                 120 


<210>  43
<211>  1218
<212>  DNA
<213>  Homo sapiens

<400>  43
atggcagcca gcgggaagac cagcaagtcc gaaccgaacc atgttatctt caagaagatc       60

tcccgggaca aatcggtgac catctacctg gggaacagag actacataga ccatgtcagc      120

caagtccagc ctgtggatgg tgtcgtgttg gttgatcctg atcttgtgaa gggaaagaaa      180

gtgtatgtca ctctgacctg cgccttccgc tatggccaag aggacattga cgtgatcggc      240

ttgaccttcc gcagggacct gtacttctcc cgggtccagg tgtatcctcc tgtgggggcc      300

gcgagcaccc ccacaaaact gcaagagagc ctgcttaaaa agctggggag caacacgtac      360

ccctttctcc tgacgtttcc tgactacttg ccctgttcag tgatgttgca gccagctcca      420

caagattcag ggaagtcctg tggggttgac tttgaggtca aagcattcgc cacagacagc      480

accgatgccg aagaggacaa aatccccaag aagagctccg tgcgattact gatccgcaaa      540

gtacagcatg ccccacttga gatgggtccc cagccccgag ctgaggcggc ctggcagttc      600

ttcatgtctg acaagcccct gcaccttgcg gtctctctca acaaagagat ctatttccat      660

ggggagccca tccctgtgac cgtgactgtc accaataaca cagagaagac cgtgaagaag      720

attaaagcat tcgtggaaca ggtggccaat gtggttctct actcgagtga ttattacgtc      780

aagcccgtgg ctatggagga agcgcaagaa aaagtgccac caaacagcac tttgaccaag      840

acgctgacgc tgctgccctt gctggctaac aatcgagaaa ggagaggcat tgccctggat      900

gggaaaatca agcacgagga cacaaacctt gcctccagca ccatcattaa ggagggcata      960

gaccggaccg tcctgggaat cctggtgtct taccagatca aggtgaagct cacagtgtca     1020

ggctttctgg gagagctcac ctccagtgaa gtcgccactg aggtcccatt ccgcctcatg     1080

caccctcagc ctgaggaccc agctaaggaa agttatcagg atgcaaattt agtttttgag     1140

gagtttgctc gccataatct gaaagatgca ggagaagctg aggaggggaa gagagacaag     1200

aatgacgttg atgagtga                                                   1218


<210>  44
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Ala Ser Gly Lys Thr Ser Lys Ser Glu Pro Asn His Val Ile 
1               5                   10                  15      


Phe Lys Lys Ile Ser Arg Asp Lys Ser Val Thr Ile Tyr Leu Gly Asn 
            20                  25                  30          


Arg Asp Tyr Ile Asp His Val Ser Gln Val Gln Pro Val Asp Gly Val 
        35                  40                  45              


Val Leu Val Asp Pro Asp Leu Val Lys Gly Lys Lys Val Tyr Val Thr 
    50                  55                  60                  


Leu Thr Cys Ala Phe Arg Tyr Gly Gln Glu Asp Ile Asp Val Ile Gly 
65                  70                  75                  80  


Leu Thr Phe Arg Arg Asp Leu Tyr Phe Ser Arg Val Gln Val Tyr Pro 
                85                  90                  95      


Pro Val Gly Ala Ala Ser Thr Pro Thr Lys Leu Gln Glu Ser Leu Leu 
            100                 105                 110         


Lys Lys Leu Gly Ser Asn Thr Tyr Pro Phe Leu Leu Thr Phe Pro Asp 
        115                 120                 125             


Tyr Leu Pro Cys Ser Val Met Leu Gln Pro Ala Pro Gln Asp Ser Gly 
    130                 135                 140                 


Lys Ser Cys Gly Val Asp Phe Glu Val Lys Ala Phe Ala Thr Asp Ser 
145                 150                 155                 160 


Thr Asp Ala Glu Glu Asp Lys Ile Pro Lys Lys Ser Ser Val Arg Leu 
                165                 170                 175     


Leu Ile Arg Lys Val Gln His Ala Pro Leu Glu Met Gly Pro Gln Pro 
            180                 185                 190         


Arg Ala Glu Ala Ala Trp Gln Phe Phe Met Ser Asp Lys Pro Leu His 
        195                 200                 205             


Leu Ala Val Ser Leu Asn Lys Glu Ile Tyr Phe His Gly Glu Pro Ile 
    210                 215                 220                 


Pro Val Thr Val Thr Val Thr Asn Asn Thr Glu Lys Thr Val Lys Lys 
225                 230                 235                 240 


Ile Lys Ala Phe Val Glu Gln Val Ala Asn Val Val Leu Tyr Ser Ser 
                245                 250                 255     


Asp Tyr Tyr Val Lys Pro Val Ala Met Glu Glu Ala Gln Glu Lys Val 
            260                 265                 270         


Pro Pro Asn Ser Thr Leu Thr Lys Thr Leu Thr Leu Leu Pro Leu Leu 
        275                 280                 285             


Ala Asn Asn Arg Glu Arg Arg Gly Ile Ala Leu Asp Gly Lys Ile Lys 
    290                 295                 300                 


His Glu Asp Thr Asn Leu Ala Ser Ser Thr Ile Ile Lys Glu Gly Ile 
305                 310                 315                 320 


Asp Arg Thr Val Leu Gly Ile Leu Val Ser Tyr Gln Ile Lys Val Lys 
                325                 330                 335     


Leu Thr Val Ser Gly Phe Leu Gly Glu Leu Thr Ser Ser Glu Val Ala 
            340                 345                 350         


Thr Glu Val Pro Phe Arg Leu Met His Pro Gln Pro Glu Asp Pro Ala 
        355                 360                 365             


Lys Glu Ser Tyr Gln Asp Ala Asn Leu Val Phe Glu Glu Phe Ala Arg 
    370                 375                 380                 


His Asn Leu Lys Asp Ala Gly Glu Ala Glu Glu Gly Lys Arg Asp Lys 
385                 390                 395                 400 


Asn Asp Val Asp Glu 
                405 


<210>  45
<211>  6860
<212>  DNA
<213>  Homo sapiens

<400>  45
atgggcttcg tgagacagat acagcttttg ctctggaaga actggaccct gcggaaaagg       60

caaaagattc gctttgtggt ggaactcgtg tggcctttat ctttatttct ggtcttgatc      120

tggttaagga atgccaaccc actctacagc catcatgaat gccatttccc caacaaggcg      180

atgccctcag caggaatgct gccgtggctc caggggatct tctgcaatgt gaacaatccc      240

tgttttcaaa gccccacccc aggagaatct cctggaattg tgtcaaacta taacaactcc      300

atcttggcaa gggtatatcg agattttcaa gaactcctca tgaatgcacc agagagccag      360

caccttggcc gtatttggac agagctacac atcttgtccc aattcatgga caccctccgg      420

actcacccgg agagaattgc aggaagagga atacgaataa gggatatctt gaaagatgaa      480

gaaacactga cactatttct cattaaaaac atcggcctgt ctgactcagt ggtctacctt      540

ctgatcaact ctcaagtccg tccagagcag ttcgctcatg gagtcccgga cctggcgctg      600

aaggacatcg cctgcagcga ggccctcctg gagcgcttca tcatcttcag ccagagacgc      660

ggggcaaaga cggtgcgcta tgccctgtgc tccctctccc agggcaccct acagtggata      720

gaagacactc tgtatgccaa cgtggacttc ttcaagctct tccgtgtgct tcccacactc      780

ctagacagcc gttctcaagg tatcaatctg agatcttggg gaggaatatt atctgatatg      840

tcaccaagaa ttcaagagtt tatccatcgg ccgagtatgc aggacttgct gtgggtgacc      900

aggcccctca tgcagaatgg tggtccagag acctttacaa agctgatggg catcctgtct      960

gacctcctgt gtggctaccc cgagggaggt ggctctcggg tgctctcctt caactggtat     1020

gaagacaata actataaggc ctttctgggg attgactcca caaggaagga tcctatctat     1080

tcttatgaca gaagaacaac atccttttgt aatgcattga tccagagcct ggagtcaaat     1140

cctttaacca aaatcgcttg gagggcggca aagcctttgc tgatgggaaa aatcctgtac     1200

actcctgatt cacctgcagc acgaaggata ctgaagaatg ccaactcaac ttttgaagaa     1260

ctggaacacg ttaggaagtt ggtcaaagcc tgggaagaag tagggcccca gatctggtac     1320

ttctttgaca acagcacaca gatgaacatg atcagagata ccctggggaa cccaacagta     1380

aaagactttt tgaataggca gcttggtgaa gaaggtatta ctgctgaagc catcctaaac     1440

ttcctctaca agggccctcg ggaaagccag gctgacgaca tggccaactt cgactggagg     1500

gacatattta acatcactga tcgcaccctc cgcctggtca atcaatacct ggagtgcttg     1560

gtcctggata agtttgaaag ctacaatgat gaaactcagc tcacccaacg tgccctctct     1620

ctactggagg aaaacatgtt ctgggccgga gtggtattcc ctgacatgta tccctggacc     1680

agctctctac caccccacgt gaagtataag atccgaatgg acatagacgt ggtggagaaa     1740

accaataaga ttaaagacag gtattgggat tctggtccca gagctgatcc cgtggaagat     1800

ttccggtaca tctggggcgg gtttgcctat ctgcaggaca tggttgaaca ggggatcaca     1860

aggagccagg tgcaggcgga ggctccagtt ggaatctacc tccagcagat gccctacccc     1920

tgcttcgtgg acgattcttt catgatcatc ctgaaccgct gtttccctat cttcatggtg     1980

ctggcatgga tctactctgt ctccatgact gtgaagagca tcgtcttgga gaaggagttg     2040

cgactgaagg agaccttgaa aaatcagggt gtctccaatg cagtgatttg gtgtacctgg     2100

ttcctggaca gcttctccat catgtcgatg agcatcttcc tcctgacgat attcatcatg     2160

catggaagaa tcctacatta cagcgaccca ttcatcctct tcctgttctt gttggctttc     2220

tccactgcca ccatcatgct gtgctttctg ctcagcacct tcttctccaa ggccagtctg     2280

gcagcagcct gtagtggtgt catctatttc accctctacc tgccacacat cctgtgcttc     2340

gcctggcagg accgcatgac cgctgagctg aagaaggctg tgagcttact gtctccggtg     2400

gcatttggat ttggcactga gtacctggtt cgctttgaag agcaaggcct ggggctgcag     2460

tggagcaaca tcgggaacag tcccacggaa ggggacgaat tcagcttcct gctgtccatg     2520

cagatgatgc tccttgatgc tgctgtctat ggcttactcg cttggtacct tgatcaggtg     2580

tttccaggag actatggaac cccacttcct tggtactttc ttctacaaga gtcgtattgg     2640

cttggcggtg aagggtgttc aaccagagaa gaaagagccc tggaaaagac cgagccccta     2700

acagaggaaa cggaggatcc agagcaccca gaaggaatac acgactcctt ctttgaacgt     2760

gagcatccag ggtgggttcc tggggtatgc gtgaagaatc tggtaaagat ttttgagccc     2820

tgtggccggc cagctgtgga ccgtctgaac atcaccttct acgagaacca gatcaccgca     2880

ttcctgggcc acaatggagc tgggaaaacc accaccttgt ccatcctgac gggtctgttg     2940

ccaccaacct ctgggactgt gctcgttggg ggaagggaca ttgaaaccag cctggatgca     3000

gtccggcaga gccttggcat gtgtccacag cacaacatcc tgttccacca cctcacggtg     3060

gctgagcaca tgctgttcta tgcccagctg aaaggaaagt cccaggagga ggcccagctg     3120

gagatggaag ccatgttgga ggacacaggc ctccaccaca agcggaatga agaggctcag     3180

gacctatcag gtggcatgca gagaaagctg tcggttgcca ttgcctttgt gggagatgcc     3240

aaggtggtga ttctggacga acccacctct ggggtggacc cttactcgag acgctcaatc     3300

tgggatctgc tcctgaagta tcgctcaggc agaaccatca tcatgtccac tcaccacatg     3360

gacgaggccg acctccttgg ggaccgcatt gccatcattg cccagggaag gctctactgc     3420

tcaggcaccc atgggcttcg tgagacagat acagcttttg ctctggaaga actggaccct     3480

gcggaaaagg caaaagattc gctttgtggt ggaactcgtg tggcctttat ctttatttct     3540

ggtcttgatc tggttaagga atgccaaccc actctacagc catcatgaat gccatttccc     3600

caacaaggcg atgccctcag caggaatgct gccgtggctc caggggatct tctgcaatgt     3660

gaacaatccc tgttttcaaa gccccacccc aggagaatct cctggaattg tgtcaaacta     3720

taacaactcc atcttggcaa gggtatatcg agattttcaa gaactcctca tgaatgcacc     3780

agagagccag caccttggcc gtatttggac agagctacac atcttgtccc aattcatgga     3840

caccctccgg actcacccgg agagaattgc aggaagagga atacgaataa gggatatctt     3900

gaaagatgaa gaaacactga cactatttct cattaaaaac atcggcctgt ctgactcagt     3960

ggtctacctt ctgatcaact ctcaagtccg tccagagcag ttcgctcatg gagtcccgga     4020

cctggcgctg aaggacatcg cctgcagcga ggccctcctg gagcgcttca tcatcttcag     4080

ccagagacgc ggggcaaaga cggtgcgcta tgccctgtgc tccctctccc agggcaccct     4140

acagtggata gaagacactc tgtatgccaa cgtggacttc ttcaagctct tccgtgtgct     4200

tcccacactc ctagacagcc gttctcaagg tatcaatctg agatcttggg gaggaatatt     4260

atctgatatg tcaccaagaa ttcaagagtt tatccatcgg ccgagtatgc aggacttgct     4320

gtgggtgacc aggcccctca tgcagaatgg tggtccagag acctttacaa agctgatggg     4380

catcctgtct gacctcctgt gtggctaccc cgagggaggt ggctctcggg tgctctcctt     4440

caactggtat gaagacaata actataaggc ctttctgggg attgactcca caaggaagga     4500

tcctatctat tcttatgaca gaagaacaac atccttttgt aatgcattga tccagagcct     4560

ggagtcaaat cctttaacca aaatcgcttg gagggcggca aagcctttgc tgatgggaaa     4620

aatcctgtac actcctgatt cacctgcagc acgaaggata ctgaagaatg ccaactcaac     4680

ttttgaagaa ctggaacacg ttaggaagtt ggtcaaagcc tgggaagaag tagggcccca     4740

gatctggtac ttctttgaca acagcacaca gatgaacatg atcagagata ccctggggaa     4800

cccaacagta aaagactttt tgaataggca gcttggtgaa gaaggtatta ctgctgaagc     4860

catcctaaac ttcctctaca agggccctcg ggaaagccag gctgacgaca tggccaactt     4920

cgactggagg gacatattta acatcactga tcgcaccctc cgcctggtca atcaatacct     4980

ggagtgcttg gtcctggata agtttgaaag ctacaatgat gaaactcagc tcacccaacg     5040

tgccctctct ctactggagg aaaacatgtt ctgggccgga gtggtattcc ctgacatgta     5100

tccctggacc agctctctac caccccacgt gaagtataag atccgaatgg acatagacgt     5160

ggtggagaaa accaataaga ttaaagacag gtattgggat tctggtccca gagctgatcc     5220

cgtggaagat ttccggtaca tctggggcgg gtttgcctat ctgcaggaca tggttgaaca     5280

ggggatcaca aggagccagg tgcaggcgga ggctccagtt ggaatctacc tccagcagat     5340

gccctacccc tgcttcgtgg acgattcttt catgatcatc ctgaaccgct gtttccctat     5400

cttcatggtg ctggcatgga tctactctgt ctccatgact gtgaagagca tcgtcttgga     5460

gaaggagttg cgactgaagg agaccttgaa aaatcagggt gtctccaatg cagtgatttg     5520

gtgtacctgg ttcctggaca gcttctccat catgtcgatg agcatcttcc tcctgacgat     5580

attcatcatg catggaagaa tcctacatta cagcgaccca ttcatcctct tcctgttctt     5640

gttggctttc tccactgcca ccatcatgct gtgctttctg ctcagcacct tcttctccaa     5700

ggccagtctg gcagcagcct gtagtggtgt catctatttc accctctacc tgccacacat     5760

cctgtgcttc gcctggcagg accgcatgac cgctgagctg aagaaggctg tgagcttact     5820

gtctccggtg gcatttggat ttggcactga gtacctggtt cgctttgaag agcaaggcct     5880

ggggctgcag tggagcaaca tcgggaacag tcccacggaa ggggacgaat tcagcttcct     5940

gctgtccatg cagatgatgc tccttgatgc tgctgtctat ggcttactcg cttggtacct     6000

tgatcaggtg tttccaggag actatggaac cccacttcct tggtactttc ttctacaaga     6060

gtcgtattgg cttggcggtg aagggtgttc aaccagagaa gaaagagccc tggaaaagac     6120

cgagccccta acagaggaaa cggaggatcc agagcaccca gaaggaatac acgactcctt     6180

ctttgaacgt gagcatccag ggtgggttcc tggggtatgc gtgaagaatc tggtaaagat     6240

ttttgagccc tgtggccggc cagctgtgga ccgtctgaac atcaccttct acgagaacca     6300

gatcaccgca ttcctgggcc acaatggagc tgggaaaacc accaccttgt ccatcctgac     6360

gggtctgttg ccaccaacct ctgggactgt gctcgttggg ggaagggaca ttgaaaccag     6420

cctggatgca gtccggcaga gccttggcat gtgtccacag cacaacatcc tgttccacca     6480

cctcacggtg gctgagcaca tgctgttcta tgcccagctg aaaggaaagt cccaggagga     6540

ggcccagctg gagatggaag ccatgttgga ggacacaggc ctccaccaca agcggaatga     6600

agaggctcag gacctatcag gtggcatgca gagaaagctg tcggttgcca ttgcctttgt     6660

gggagatgcc aaggtggtga ttctggacga acccacctct ggggtggacc cttactcgag     6720

acgctcaatc tgggatctgc tcctgaagta tcgctcaggc agaaccatca tcatgtccac     6780

tcaccacatg gacgaggccg acctccttgg ggaccgcatt gccatcattg cccagggaag     6840

gctctactgc tcaggcaccc                                                 6860


<210>  46
<211>  2273
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          


Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              


Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      


Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         


Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             


Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 


Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 


Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     


Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         


His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             


Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 


Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 


Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     


Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         


Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             


His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 


Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 


Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     


Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         


Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             


Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 


Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 


Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     


Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         


Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             


Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 


Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 


Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     


Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         


Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             


Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 


Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 


Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     


Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         


Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             


Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 


Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 


Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     


Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         


Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             


Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 


Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 


His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     


Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         


Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             


Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 


Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 


Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     


Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         


Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             


Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 


Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 


Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     


Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         


Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             


Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 


Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 


Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     


Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         


Asp Ile Glu Thr Ser Leu Asp Ala  Val Arg Gln Ser Leu  Gly Met Cys 
        995                 1000                 1005             


Pro Gln  His Asn Ile Leu Phe  His His Leu Thr Val  Ala Glu His 
    1010                 1015                 1020             


Met Leu  Phe Tyr Ala Gln Leu  Lys Gly Lys Ser Gln  Glu Glu Ala 
    1025                 1030                 1035             


Gln Leu  Glu Met Glu Ala Met  Leu Glu Asp Thr Gly  Leu His His 
    1040                 1045                 1050             


Lys Arg  Asn Glu Glu Ala Gln  Asp Leu Ser Gly Gly  Met Gln Arg 
    1055                 1060                 1065             


Lys Leu  Ser Val Ala Ile Ala  Phe Val Gly Asp Ala  Lys Val Val 
    1070                 1075                 1080             


Ile Leu  Asp Glu Pro Thr Ser  Gly Val Asp Pro Tyr  Ser Arg Arg 
    1085                 1090                 1095             


Ser Ile  Trp Asp Leu Leu Leu  Lys Tyr Arg Ser Gly  Arg Thr Ile 
    1100                 1105                 1110             


Ile Met  Ser Thr His His Met  Asp Glu Ala Asp Leu  Leu Gly Asp 
    1115                 1120                 1125             


Arg Ile  Ala Ile Ile Ala Gln  Gly Arg Leu Tyr Cys  Ser Gly Thr 
    1130                 1135                 1140             


Pro Leu  Phe Leu Lys Asn Cys  Phe Gly Thr Gly Leu  Tyr Leu Thr 
    1145                 1150                 1155             


Leu Val  Arg Lys Met Lys Asn  Ile Gln Ser Gln Arg  Lys Gly Ser 
    1160                 1165                 1170             


Glu Gly  Thr Cys Ser Cys Ser  Ser Lys Gly Phe Ser  Thr Thr Cys 
    1175                 1180                 1185             


Pro Ala  His Val Asp Asp Leu  Thr Pro Glu Gln Val  Leu Asp Gly 
    1190                 1195                 1200             


Asp Val  Asn Glu Leu Met Asp  Val Val Leu His His  Val Pro Glu 
    1205                 1210                 1215             


Ala Lys  Leu Val Glu Cys Ile  Gly Gln Glu Leu Ile  Phe Leu Leu 
    1220                 1225                 1230             


Pro Asn  Lys Asn Phe Lys His  Arg Ala Tyr Ala Ser  Leu Phe Arg 
    1235                 1240                 1245             


Glu Leu  Glu Glu Thr Leu Ala  Asp Leu Gly Leu Ser  Ser Phe Gly 
    1250                 1255                 1260             


Ile Ser  Asp Thr Pro Leu Glu  Glu Ile Phe Leu Lys  Val Thr Glu 
    1265                 1270                 1275             


Asp Ser  Asp Ser Gly Pro Leu  Phe Ala Gly Gly Ala  Gln Gln Lys 
    1280                 1285                 1290             


Arg Glu  Asn Val Asn Pro Arg  His Pro Cys Leu Gly  Pro Arg Glu 
    1295                 1300                 1305             


Lys Ala  Gly Gln Thr Pro Gln  Asp Ser Asn Val Cys  Ser Pro Gly 
    1310                 1315                 1320             


Ala Pro  Ala Ala His Pro Glu  Gly Gln Pro Pro Pro  Glu Pro Glu 
    1325                 1330                 1335             


Cys Pro  Gly Pro Gln Leu Asn  Thr Gly Thr Gln Leu  Val Leu Gln 
    1340                 1345                 1350             


His Val  Gln Ala Leu Leu Val  Lys Arg Phe Gln His  Thr Ile Arg 
    1355                 1360                 1365             


Ser His  Lys Asp Phe Leu Ala  Gln Ile Val Leu Pro  Ala Thr Phe 
    1370                 1375                 1380             


Val Phe  Leu Ala Leu Met Leu  Ser Ile Val Ile Pro  Pro Phe Gly 
    1385                 1390                 1395             


Glu Tyr  Pro Ala Leu Thr Leu  His Pro Trp Ile Tyr  Gly Gln Gln 
    1400                 1405                 1410             


Tyr Thr  Phe Phe Ser Met Asp  Glu Pro Gly Ser Glu  Gln Phe Thr 
    1415                 1420                 1425             


Val Leu  Ala Asp Val Leu Leu  Asn Lys Pro Gly Phe  Gly Asn Arg 
    1430                 1435                 1440             


Cys Leu  Lys Glu Gly Trp Leu  Pro Glu Tyr Pro Cys  Gly Asn Ser 
    1445                 1450                 1455             


Thr Pro  Trp Lys Thr Pro Ser  Val Ser Pro Asn Ile  Thr Gln Leu 
    1460                 1465                 1470             


Phe Gln  Lys Gln Lys Trp Thr  Gln Val Asn Pro Ser  Pro Ser Cys 
    1475                 1480                 1485             


Arg Cys  Ser Thr Arg Glu Lys  Leu Thr Met Leu Pro  Glu Cys Pro 
    1490                 1495                 1500             


Glu Gly  Ala Gly Gly Leu Pro  Pro Pro Gln Arg Thr  Gln Arg Ser 
    1505                 1510                 1515             


Thr Glu  Ile Leu Gln Asp Leu  Thr Asp Arg Asn Ile  Ser Asp Phe 
    1520                 1525                 1530             


Leu Val  Lys Thr Tyr Pro Ala  Leu Ile Arg Ser Ser  Leu Lys Ser 
    1535                 1540                 1545             


Lys Phe  Trp Val Asn Glu Gln  Arg Tyr Gly Gly Ile  Ser Ile Gly 
    1550                 1555                 1560             


Gly Lys  Leu Pro Val Val Pro  Ile Thr Gly Glu Ala  Leu Val Gly 
    1565                 1570                 1575             


Phe Leu  Ser Asp Leu Gly Arg  Ile Met Asn Val Ser  Gly Gly Pro 
    1580                 1585                 1590             


Ile Thr  Arg Glu Ala Ser Lys  Glu Ile Pro Asp Phe  Leu Lys His 
    1595                 1600                 1605             


Leu Glu  Thr Glu Asp Asn Ile  Lys Val Trp Phe Asn  Asn Lys Gly 
    1610                 1615                 1620             


Trp His  Ala Leu Val Ser Phe  Leu Asn Val Ala His  Asn Ala Ile 
    1625                 1630                 1635             


Leu Arg  Ala Ser Leu Pro Lys  Asp Arg Ser Pro Glu  Glu Tyr Gly 
    1640                 1645                 1650             


Ile Thr  Val Ile Ser Gln Pro  Leu Asn Leu Thr Lys  Glu Gln Leu 
    1655                 1660                 1665             


Ser Glu  Ile Thr Val Leu Thr  Thr Ser Val Asp Ala  Val Val Ala 
    1670                 1675                 1680             


Ile Cys  Val Ile Phe Ser Met  Ser Phe Val Pro Ala  Ser Phe Val 
    1685                 1690                 1695             


Leu Tyr  Leu Ile Gln Glu Arg  Val Asn Lys Ser Lys  His Leu Gln 
    1700                 1705                 1710             


Phe Ile  Ser Gly Val Ser Pro  Thr Thr Tyr Trp Val  Thr Asn Phe 
    1715                 1720                 1725             


Leu Trp  Asp Ile Met Asn Tyr  Ser Val Ser Ala Gly  Leu Val Val 
    1730                 1735                 1740             


Gly Ile  Phe Ile Gly Phe Gln  Lys Lys Ala Tyr Thr  Ser Pro Glu 
    1745                 1750                 1755             


Asn Leu  Pro Ala Leu Val Ala  Leu Leu Leu Leu Tyr  Gly Trp Ala 
    1760                 1765                 1770             


Val Ile  Pro Met Met Tyr Pro  Ala Ser Phe Leu Phe  Asp Val Pro 
    1775                 1780                 1785             


Ser Thr  Ala Tyr Val Ala Leu  Ser Cys Ala Asn Leu  Phe Ile Gly 
    1790                 1795                 1800             


Ile Asn  Ser Ser Ala Ile Thr  Phe Ile Leu Glu Leu  Phe Glu Asn 
    1805                 1810                 1815             


Asn Arg  Thr Leu Leu Arg Phe  Asn Ala Val Leu Arg  Lys Leu Leu 
    1820                 1825                 1830             


Ile Val  Phe Pro His Phe Cys  Leu Gly Arg Gly Leu  Ile Asp Leu 
    1835                 1840                 1845             


Ala Leu  Ser Gln Ala Val Thr  Asp Val Tyr Ala Arg  Phe Gly Glu 
    1850                 1855                 1860             


Glu His  Ser Ala Asn Pro Phe  His Trp Asp Leu Ile  Gly Lys Asn 
    1865                 1870                 1875             


Leu Phe  Ala Met Val Val Glu  Gly Val Val Tyr Phe  Leu Leu Thr 
    1880                 1885                 1890             


Leu Leu  Val Gln Arg His Phe  Phe Leu Ser Gln Trp  Ile Ala Glu 
    1895                 1900                 1905             


Pro Thr  Lys Glu Pro Ile Val  Asp Glu Asp Asp Asp  Val Ala Glu 
    1910                 1915                 1920             


Glu Arg  Gln Arg Ile Ile Thr  Gly Gly Asn Lys Thr  Asp Ile Leu 
    1925                 1930                 1935             


Arg Leu  His Glu Leu Thr Lys  Ile Tyr Pro Gly Thr  Ser Ser Pro 
    1940                 1945                 1950             


Ala Val  Asp Arg Leu Cys Val  Gly Val Arg Pro Gly  Glu Cys Phe 
    1955                 1960                 1965             


Gly Leu  Leu Gly Val Asn Gly  Ala Gly Lys Thr Thr  Thr Phe Lys 
    1970                 1975                 1980             


Met Leu  Thr Gly Asp Thr Thr  Val Thr Ser Gly Asp  Ala Thr Val 
    1985                 1990                 1995             


Ala Gly  Lys Ser Ile Leu Thr  Asn Ile Ser Glu Val  His Gln Asn 
    2000                 2005                 2010             


Met Gly  Tyr Cys Pro Gln Phe  Asp Ala Ile Asp Glu  Leu Leu Thr 
    2015                 2020                 2025             


Gly Arg  Glu His Leu Tyr Leu  Tyr Ala Arg Leu Arg  Gly Val Pro 
    2030                 2035                 2040             


Ala Glu  Glu Ile Glu Lys Val  Ala Asn Trp Ser Ile  Lys Ser Leu 
    2045                 2050                 2055             


Gly Leu  Thr Val Tyr Ala Asp  Cys Leu Ala Gly Thr  Tyr Ser Gly 
    2060                 2065                 2070             


Gly Asn  Lys Arg Lys Leu Ser  Thr Ala Ile Ala Leu  Ile Gly Cys 
    2075                 2080                 2085             


Pro Pro  Leu Val Leu Leu Asp  Glu Pro Thr Thr Gly  Met Asp Pro 
    2090                 2095                 2100             


Gln Ala  Arg Arg Met Leu Trp  Asn Val Ile Val Ser  Ile Ile Arg 
    2105                 2110                 2115             


Glu Gly  Arg Ala Val Val Leu  Thr Ser His Ser Met  Glu Glu Cys 
    2120                 2125                 2130             


Glu Ala  Leu Cys Thr Arg Leu  Ala Ile Met Val Lys  Gly Ala Phe 
    2135                 2140                 2145             


Arg Cys  Met Gly Thr Ile Gln  His Leu Lys Ser Lys  Phe Gly Asp 
    2150                 2155                 2160             


Gly Tyr  Ile Val Thr Met Lys  Ile Lys Ser Pro Lys  Asp Asp Leu 
    2165                 2170                 2175             


Leu Pro  Asp Leu Asn Pro Val  Glu Gln Phe Phe Gln  Gly Asn Phe 
    2180                 2185                 2190             


Pro Gly  Ser Val Gln Arg Glu  Arg His Tyr Asn Met  Leu Gln Phe 
    2195                 2200                 2205             


Gln Val  Ser Ser Ser Ser Leu  Ala Arg Ile Phe Gln  Leu Leu Leu 
    2210                 2215                 2220             


Ser His  Lys Asp Ser Leu Leu  Ile Glu Glu Tyr Ser  Val Thr Gln 
    2225                 2230                 2235             


Thr Thr  Leu Asp Gln Val Phe  Val Asn Phe Ala Lys  Gln Gln Thr 
    2240                 2245                 2250             


Glu Ser  His Asp Leu Pro Leu  His Pro Arg Ala Ala  Gly Ala Ser 
    2255                 2260                 2265             


Arg Gln  Ala Gln Asp 
    2270             


<210>  47
<211>  2430
<212>  DNA
<213>  Homo sapiens

<400>  47
atgtttaaat cgctgacaaa agtcaacaag gtgaagccta taggagagaa caatgagaat       60

gaacaaagtt ctcgtcggaa tgaagaaggc tctcacccaa gtaatcagtc tcagcaaacc      120

acagcacagg aagaaaacaa aggtgaagag aaatctctca aaaccaagtc aactccagtc      180

acgtctgaag agccacacac caacatacaa gacaaactct ccaagaaaaa ttcctctgga      240

gatctgacca caaaccctga ccctcaaaat gcagcagaac caactggaac agtgccagag      300

cagaaggaaa tggaccccgg gaaagaaggt ccaaacagcc cacaaaacaa accgcctgca      360

gctcctgtta taaatgagta tgccgatgcc cagctacaca acctggtgaa aagaatgcgt      420

caaagaacag ccctctacaa gaaaaagttg gtagagggag atctctcctc acccgaagcc      480

agcccacaaa ctgcaaagcc cacggctgta ccaccagtaa aagaaagcga tgataagcca      540

acagaacatt actacaggct gttgtggttc aaagtcaaaa agatgccttt aacagagtac      600

ttaaagcgaa ttaaacttcc aaacagcata gattcataca cagatcgact ctatctcctg      660

tggctcttgc ttgtcactct tgcctataac tggaactgct gttttatacc actgcgcctc      720

gtcttcccat atcaaaccgc agacaacata cactactggc ttattgcgga catcatatgt      780

gatatcatct acctttatga tatgctattt atccagccca gactccagtt tgtaagagga      840

ggagacataa tagtggattc aaatgagcta aggaaacact acaggacttc tacaaaattt      900

cagttggatg tcgcatcaat aataccattt gatatttgct acctcttctt tgggtttaat      960

ccaatgttta gagcaaatag gatgttaaag tacacttcat tttttgaatt taatcatcac     1020

ctagagtcta taatggacaa agcatatatc tacagagtta ttcgaacaac tggatacttg     1080

ctgtttattc tgcacattaa tgcctgtgtt tattactggg cttcaaacta tgaaggaatt     1140

ggcactacta gatgggtgta tgatggggaa ggaaacgagt atctgagatg ttattattgg     1200

gcagttcgaa ctttaattac cattggtggc cttccagaac cacaaacttt atttgaaatt     1260

gtttttcaac tcttgaattt tttttctgga gtttttgtgt tctccagttt aattggtcag     1320

atgagagatg tgattggagc agctacagcc aatcagaact acttccgcgc ctgcatggat     1380

gacaccattg cctacatgaa caattactcc attcctaaac ttgtgcaaaa gcgagttcgg     1440

acttggtatg aatatacatg ggactctcaa agaatgctag atgagtctga tttgcttaag     1500

accctaccaa ctacggtcca gttagccctc gccattgatg tgaacttcag catcatcagc     1560

aaagtcgact tgttcaaggg ttgtgataca cagatgattt atgacatgtt gctaagattg     1620

aaatccgttc tctatttgcc tggtgacttt gtctgcaaaa agggagaaat tggcaaggaa     1680

atgtatatca tcaagcatgg agaagtccaa gttcttggag gccctgatgg tactaaagtt     1740

ctggttactc tgaaagctgg gtcggtgttt ggagaaatca gccttctagc agcaggagga     1800

ggaaaccgtc gaactgccaa tgtggtggcc cacgggtttg ccaatctttt aactctagac     1860

aaaaagaccc tccaagaaat tctagtgcat tatccagatt ctgaaaggat cctcatgaag     1920

aaagccagag tgcttttaaa gcagaaggct aagaccgcag aagcaacccc tccaagaaaa     1980

gatcttgccc tcctcttccc accgaaagaa gagacaccca aactgtttaa aactctccta     2040

ggaggcacag gaaaagcaag tcttgcaaga ctactcaaat tgaagcgaga gcaagcagct     2100

cagaagaaag aaaattctga aggaggagag gaagaaggaa aagaaaatga agataaacaa     2160

aaagaaaatg aagataaaca aaaagaaaat gaagataaag gaaaagaaaa tgaagataaa     2220

gataaaggaa gagagccaga agagaagcca ctggacagac ctgaatgtac agcaagtcct     2280

attgcagtgg aggaagaacc ccactcagtt agaaggacag ttttacccag agggacttct     2340

cgtcaatcac tcattatcag catggctcct tctgctgagg gcggagaaga ggttcttact     2400

attgaagtca aagaaaaggc taagcaataa                                      2430


<210>  48
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  48

Lys Ser Val Leu Tyr Leu Pro Gly Asp Phe Val Cys Lys Lys Gly Glu 
1               5                   10                  15      


Ile Gly Lys Glu Met Tyr Ile Ile Lys His Gly Glu Val Gln Val Leu 
            20                  25                  30          


Gly Gly Pro Asp Gly Thr Lys Val Leu Val Thr Leu Lys Ala Gly Ser 
        35                  40                  45              


Val Phe Gly Glu Ile Ser Leu Leu Ala Ala Gly Gly Gly Asn Arg Arg 
    50                  55                  60                  


Thr Ala Asn Val Val Ala His Gly Phe Ala Asn Leu Leu Thr Leu Asp 
65                  70                  75                  80  


Lys Lys Thr Leu Gln Glu Ile Leu Val His Tyr Pro Asp Ser Glu Arg 
                85                  90                  95      


Ile Leu Met Lys Lys Ala Arg Val Leu Leu Lys Gln Lys Ala Lys Thr 
            100                 105                 110         


Ala Glu Ala Thr Pro Pro Arg Lys Asp Leu Ala Leu Leu Phe Pro Pro 
        115                 120                 125             


Lys Glu Glu Thr Pro Lys Leu Phe Lys Thr Leu Leu Gly Gly Thr Gly 
    130                 135                 140                 


Lys Ala Ser Leu Ala Arg Leu Leu Lys Leu Lys Arg Glu Gln Ala Ala 
145                 150                 155                 160 


Gln Lys Lys Glu Asn Ser Glu Gly Gly Glu Glu Glu Gly Lys Glu Asn 
                165                 170                 175     


Glu Asp Lys Gln Lys Glu Asn Glu Asp Lys Gln Lys Glu Asn Glu Asp 
            180                 185                 190         


Lys Gly Lys Glu Asn Glu Asp Lys Asp Lys Gly Arg Glu Pro Glu Glu 
        195                 200                 205             


Lys Pro Leu Asp Arg Pro Glu Cys Thr Ala Ser Pro Ile Ala Val Glu 
    210                 215                 220                 


Glu Glu Pro His Ser Val Arg Arg Thr Val Leu Pro Arg Gly Thr Ser 
225                 230                 235                 240 


Arg Gln Ser Leu Ile Ile Ser Met Ala Pro Ser Ala Glu Gly Gly Glu 
                245                 250                 255     


Glu Val Leu Thr Ile Glu Val Lys Glu Lys Ala Lys Gln Lys Ser Val 
            260                 265                 270         


Leu Tyr Leu Pro Gly Asp Phe Val Cys Lys Lys Gly Glu Ile Gly Lys 
        275                 280                 285             


Glu Met Tyr Ile Ile Lys His Gly Glu Val Gln Val Leu Gly Gly Pro 
    290                 295                 300                 


Asp Gly Thr Lys Val Leu Val Thr Leu Lys Ala Gly Ser Val Phe Gly 
305                 310                 315                 320 


Glu Ile Ser Leu Leu Ala Ala Gly Gly Gly Asn Arg Arg Thr Ala Asn 
                325                 330                 335     


Val Val Ala His Gly Phe Ala Asn Leu Leu Thr Leu Asp Lys Lys Thr 
            340                 345                 350         


Leu Gln Glu Ile Leu Val His Tyr Pro Asp Ser Glu Arg Ile Leu Met 
        355                 360                 365             


Lys Lys Ala Arg Val Leu Leu Lys Gln Lys Ala Lys Thr Ala Glu Ala 
    370                 375                 380                 


Thr Pro Pro Arg Lys Asp Leu Ala Leu Leu Phe Pro Pro Lys Glu Glu 
385                 390                 395                 400 


Thr Pro Lys Leu Phe Lys Thr Leu Leu Gly Gly Thr Gly Lys Ala Ser 
                405                 410                 415     


Leu Ala Arg Leu Leu Lys Leu Lys Arg Glu Gln Ala Ala Gln Lys Lys 
            420                 425                 430         


Glu Asn Ser Glu Gly Gly Glu Glu Glu Gly Lys Glu Asn Glu Asp Lys 
        435                 440                 445             


Gln Lys Glu Asn Glu Asp Lys Gln Lys Glu Asn Glu Asp Lys Gly Lys 
    450                 455                 460                 


Glu Asn Glu Asp Lys Asp Lys Gly Arg Glu Pro Glu Glu Lys Pro Leu 
465                 470                 475                 480 


Asp Arg Pro Glu Cys Thr Ala Ser Pro Ile Ala Val Glu Glu Glu Pro 
                485                 490                 495     


His Ser Val Arg Arg Thr Val Leu Pro Arg Gly Thr Ser Arg Gln Ser 
            500                 505                 510         


Leu Ile Ile Ser Met Ala Pro Ser Ala Glu Gly Gly Glu Glu Val Leu 
        515                 520                 525             


Thr Ile Glu Val Lys Glu Lys Ala Lys Gln 
    530                 535             


<210>  49
<211>  666
<212>  DNA
<213>  Homo sapiens

<400>  49
atgtcggact ctgaggagga gagccaggac cggcaactga aaatcgtcgt gctgggggac       60

ggcgcctccg ggaagacctc cttaactacg tgttttgctc aagaaacttt tgggaaacag      120

tacaaacaaa ctataggact ggatttcttt ttgagaagga taacattgcc aggaaacttg      180

aatgttaccc ttcaaatttg ggatatagga gggcagacaa taggaggcaa aatgttggat      240

aaatatatct atggagcaca gggagtcctc ttggtatatg atattacaaa ttatcaaagc      300

tttgagaatt tagaagattg gtatactgtg gtgaagaaag tgagcgagga gtcagaaact      360

cagccactgg ttgccttggt aggcaataaa attgatttgg agcatatgcg aacaataaaa      420

cctgaaaaac acttacggtt ttgccaggaa aatggtttta gtagccactt tgtctcagcc      480

aagacaggag actctgtctt cctgtgcttt cagaaagttg ctgctgaaat ccttgggatc      540

aaattaaaca aagcagaaat agaacagtca cagagggtgg tgaaggcaga tattgtaaac      600

tacaaccagg aacctatgtc aaggactgtt aaccctccta gaagctctat gtgtgcagtt      660

cagtga                                                                 666


<210>  50
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ser Asp Ser Glu Glu Glu Ser Gln Asp Arg Gln Leu Lys Ile Val 
1               5                   10                  15      


Val Leu Gly Asp Gly Ala Ser Gly Lys Thr Ser Leu Thr Thr Cys Phe 
            20                  25                  30          


Ala Gln Glu Thr Phe Gly Lys Gln Tyr Lys Gln Thr Ile Gly Leu Asp 
        35                  40                  45              


Phe Phe Leu Arg Arg Ile Thr Leu Pro Gly Asn Leu Asn Val Thr Leu 
    50                  55                  60                  


Gln Ile Trp Asp Ile Gly Gly Gln Thr Ile Gly Gly Lys Met Leu Asp 
65                  70                  75                  80  


Lys Tyr Ile Tyr Gly Ala Gln Gly Val Leu Leu Val Tyr Asp Ile Thr 
                85                  90                  95      


Asn Tyr Gln Ser Phe Glu Asn Leu Glu Asp Trp Tyr Thr Val Val Lys 
            100                 105                 110         


Lys Val Ser Glu Glu Ser Glu Thr Gln Pro Leu Val Ala Leu Val Gly 
        115                 120                 125             


Asn Lys Ile Asp Leu Glu His Met Arg Thr Ile Lys Pro Glu Lys His 
    130                 135                 140                 


Leu Arg Phe Cys Gln Glu Asn Gly Phe Ser Ser His Phe Val Ser Ala 
145                 150                 155                 160 


Lys Thr Gly Asp Ser Val Phe Leu Cys Phe Gln Lys Val Ala Ala Glu 
                165                 170                 175     


Ile Leu Gly Ile Lys Leu Asn Lys Ala Glu Ile Glu Gln Ser Gln Arg 
            180                 185                 190         


Val Val Lys Ala Asp Ile Val Asn Tyr Asn Gln Glu Pro Met Ser Arg 
        195                 200                 205             


Thr Val Asn Pro Pro Arg Ser Ser Met Cys Ala Val Gln 
    210                 215                 220     


<210>  51
<211>  945
<212>  DNA
<213>  Homo sapiens

<400>  51
atggggctcc tggactcgga gccgggtagt gtcctaaacg tagtgtccac ggcactcaac       60

gacacggtag agttctaccg ctggacctgg tccatcgcag ataagcgtgt ggaaaattgg      120

cctctgatgc agtctccttg gcctacacta agtataagca ctctttatct cctgtttgtg      180

tggctgggtc caaaatggat gaaggaccga gaaccttttc agatgcgtct agtgctcatt      240

atctataatt ttgggatggt tttgcttaac ctctttatct tcagagagtt attcatggga      300

tcatataatg cgggatatag ctatatttgc cagagtgtgg attattctaa taatgttcat      360

gaagtcagga tagctgctgc tctgtggtgg tactttgtat ctaaaggagt tgagtatttg      420

gacacagtgt tttttattct gagaaagaaa aacaaccaag tttctttcct tcatgtgtat      480

catcactgta cgatgtttac cttgtggtgg attggaatta agtgggttgc aggaggacaa      540

gcattttttg gagcccagtt gaattccttt atccatgtga ttatgtactc atactatggg      600

ttaactgcat ttggcccatg gattcagaaa tatctttggt ggaaacgata cctgactatg      660

ttgcaactga ttcaattcca tgtgaccatt gggcacacgg cactgtctct ttacactgac      720

tgccccttcc ccaaatggat gcactgggct ctaattgcct atgcaatcag cttcatattt      780

ctctttctta acttctacat tcggacatac aaagagccta agaaaccaaa agctggaaaa      840

acagccatga atggtatttc agcaaatggt gtgagcaaat cagaaaaaca actcatgata      900

gaaaatggaa aaaagcagaa aaatggaaaa gcaaaaggag attaa                      945


<210>  52
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Gly Leu Leu Asp Ser Glu Pro Gly Ser Val Leu Asn Val Val Ser 
1               5                   10                  15      


Thr Ala Leu Asn Asp Thr Val Glu Phe Tyr Arg Trp Thr Trp Ser Ile 
            20                  25                  30          


Ala Asp Lys Arg Val Glu Asn Trp Pro Leu Met Gln Ser Pro Trp Pro 
        35                  40                  45              


Thr Leu Ser Ile Ser Thr Leu Tyr Leu Leu Phe Val Trp Leu Gly Pro 
    50                  55                  60                  


Lys Trp Met Lys Asp Arg Glu Pro Phe Gln Met Arg Leu Val Leu Ile 
65                  70                  75                  80  


Ile Tyr Asn Phe Gly Met Val Leu Leu Asn Leu Phe Ile Phe Arg Glu 
                85                  90                  95      


Leu Phe Met Gly Ser Tyr Asn Ala Gly Tyr Ser Tyr Ile Cys Gln Ser 
            100                 105                 110         


Val Asp Tyr Ser Asn Asn Val His Glu Val Arg Ile Ala Ala Ala Leu 
        115                 120                 125             


Trp Trp Tyr Phe Val Ser Lys Gly Val Glu Tyr Leu Asp Thr Val Phe 
    130                 135                 140                 


Phe Ile Leu Arg Lys Lys Asn Asn Gln Val Ser Phe Leu His Val Tyr 
145                 150                 155                 160 


His His Cys Thr Met Phe Thr Leu Trp Trp Ile Gly Ile Lys Trp Val 
                165                 170                 175     


Ala Gly Gly Gln Ala Phe Phe Gly Ala Gln Leu Asn Ser Phe Ile His 
            180                 185                 190         


Val Ile Met Tyr Ser Tyr Tyr Gly Leu Thr Ala Phe Gly Pro Trp Ile 
        195                 200                 205             


Gln Lys Tyr Leu Trp Trp Lys Arg Tyr Leu Thr Met Leu Gln Leu Ile 
    210                 215                 220                 


Gln Phe His Val Thr Ile Gly His Thr Ala Leu Ser Leu Tyr Thr Asp 
225                 230                 235                 240 


Cys Pro Phe Pro Lys Trp Met His Trp Ala Leu Ile Ala Tyr Ala Ile 
                245                 250                 255     


Ser Phe Ile Phe Leu Phe Leu Asn Phe Tyr Ile Arg Thr Tyr Lys Glu 
            260                 265                 270         


Pro Lys Lys Pro Lys Ala Gly Lys Thr Ala Met Asn Gly Ile Ser Ala 
        275                 280                 285             


Asn Gly Val Ser Lys Ser Glu Lys Gln Leu Met Ile Glu Asn Gly Lys 
    290                 295                 300                 


Lys Gln Lys Asn Gly Lys Ala Lys Gly Asp 
305                 310                 


<210>  53
<211>  3459
<212>  DNA
<213>  Homo sapiens

<400>  53
atgagggagc cggaagagct gatgcccgat tcgggtgctg tgtttacatt tgggaaaagt       60

aaatttgctg aaaataatcc cggtaaattc tggtttaaaa atgatgtccc tgtacatctt      120

tcatgtggag atgaacattc tgctgttgtt accggaaata ataaacttta catgtttggc      180

agtaacaact ggggtcagtt aggattagga tcaaagtcag ccatcagcaa gccaacatgt      240

gtcaaagctc taaaacctga aaaagtgaaa ttagctgcct gtggaaggaa ccacaccctg      300

gtgtcaacag aaggaggcaa tgtatatgca actggtggaa ataatgaagg acagttgggg      360

cttggtgaca ccgaagaaag aaacactttt catgtaatta gcttttttac atccgagcat      420

aagattaagc agctgtctgc tggatctaat acttcagctg ccctaactga ggatggaaga      480

ctttttatgt ggggtgacaa ttccgaaggg caaattggtt taaaaaatgt aagtaatgtc      540

tgtgtccctc agcaagtgac cattgggaaa cctgtctcct ggatctcttg tggatattac      600

cattcagctt ttgtaacaac agatggtgag ctatatgtgt ttggagaacc tgagaatggg      660

aagttaggtc ttcccaatca gctcctgggc aatcacagaa caccccagct ggtgtctgaa      720

attccggaga aggtgatcca agtagcctgt ggtggagagc atactgtggt tctcacggag      780

aatgctgtgt atacctttgg gctgggacaa tttggtcagc tgggtcttgg cacttttctt      840

tttgaaactt cagaacccaa agtcattgag aatattaggg atcaaacaat aagttatatt      900

tcttgtggag aaaatcacac agctttgata acagatatcg gccttatgta tacttttgga      960

gatggtcgcc acggaaaatt aggacttgga ctggagaatt ttaccaatca cttcattcct     1020

actttgtgct ctaatttttt gaggtttata gttaaattgg ttgcttgtgg tggatgtcac     1080

atggtagttt ttgctgctcc tcatcgtggt gtggcaaaag aaattgaatt cgatgaaata     1140

aatgatactt gcttatctgt ggcgactttt ctgccgtata gcagtttaac ctcaggaaat     1200

gtactgcaga ggactctatc agcacgtatg cggcgaagag agagggagag gtctccagat     1260

tctttttcaa tgaggagaac actacctcca atagaaggga ctcttggcct ttctgcttgt     1320

tttctcccca attcagtctt tccacgatgt tctgagagaa acctccaaga gagtgtctta     1380

tctgaacagg acctcatgca gccagaggaa ccagattatt tgctagatga aatgaccaaa     1440

gaagcagaga tagataattc ttcaactgta gaaagccttg gagaaactac tgatatctta     1500

aacatgacac acatcatgag cctgaattcc aatgaaaagt cattaaaatt atcaccagtt     1560

cagaaacaaa agaaacaaca aacaattggg gaactgacgc aggatacagc tcttactgaa     1620

aacgatgata gtgatgaata tgaagaaatg tcagaaatga aagaagggaa agcatgtaaa     1680

caacatgtgt cacaagggat tttcatgacg cagccagcta cgactatcga agcattttca     1740

gatgaggaag tagagatccc agaggagaag gaaggagcag aggattcaaa aggaaatgga     1800

atagaggagc aagaggtaga agcaaatgag gaaaatgtga aggtgcatgg aggaagaaag     1860

gagaaaacag agatcctatc agatgacctt acagacaaag cagaggtgag tgaaggcaag     1920

gcaaaatcag tgggagaagc agaggatggg cctgaaggta gaggggatgg aacctgtgag     1980

gaaggtagtt caggagcaga acactggcaa gatgaggaga gggagaaggg ggagaaagac     2040

aagggtagag gagaaatgga gaggccagga gagggagaga aggaactagc agagaaggaa     2100

gaatggaaga agagggatgg ggaagagcag gagcaaaagg agagggagca gggccatcag     2160

aaggaaagaa accaagagat ggaggaggga ggggaggagg agcatggaga aggagaagaa     2220

gaggagggag acagagaaga ggaagaagag aaggagggag aagggaaaga ggaaggagaa     2280

ggggaagaag tggagggaga acgtgaaaag gaggaaggag agaggaaaaa ggaggaaaga     2340

gcggggaagg aggagaaagg agaggaagaa ggagaccaag gagaggggga agaggaggaa     2400

acagagggga gaggggagga aaaagaggag ggaggggaag tagagggagg ggaagtagag     2460

gaggggaaag gagagaggga agaggaagag gaggagggtg agggggaaga ggaggaaggg     2520

gagggggaag aggaggaagg ggagggggaa gaggaggaag gagaagggaa aggggaggaa     2580

gaaggggaag aaggagaagg ggaggaagaa ggggaggaag gagaagggga gggggaagag     2640

gaggaaggag aaggggaggg agaagaggaa ggagaagggg agggagaaga ggaggaagga     2700

gaaggggagg gagaagagga aggagaaggg gagggagaag aggaggaagg agaagggaaa     2760

ggggaggagg aaggagagga aggagaaggg gagggggaag aggaggaagg agaaggggaa     2820

ggggaggatg gagaagggga gggggaagag gaggaaggag aatgggaggg ggaagaggag     2880

gaaggagaag gggaggggga agaggaagga gaaggggaag gggaggaagg agaaggggag     2940

ggggaagagg aggaaggaga aggggagggg gaagaggagg aaggggaaga agaaggggag     3000

gaagaaggag agggagagga agaaggggag ggagaagggg aggaagaaga ggaaggggaa     3060

gtggaagggg aggtggaagg ggaggaagga gagggggaag gagaggaaga ggaaggagag     3120

gaggaaggag aagaaaggga aaaggagggg gaaggagaag aaaacaggag gaacagagaa     3180

gaggaggagg aagaagaggg gaagtatcag gagacaggcg aagaagagaa tgaaaggcag     3240

gatggagagg agtacaaaaa agtgagcaaa ataaaaggat ctgtgaaata tggcaaacat     3300

aaaacatatc aaaaaaagtc agttactaac acacagggaa atgggaaaga gcagaggtcc     3360

aaaatgccag tccagtcaaa acgactttta aaaaacgggc catcaggttc caaaaagttc     3420

tggaataatg tattaccaca ttacttggaa ttgaagtaa                            3459


<210>  54
<211>  1020
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Arg Glu Pro Glu Glu Leu Met Pro Asp Ser Gly Ala Val Phe Thr 
1               5                   10                  15      


Phe Gly Lys Ser Lys Phe Ala Glu Asn Asn Pro Gly Lys Phe Trp Phe 
            20                  25                  30          


Lys Asn Asp Val Pro Val His Leu Ser Cys Gly Asp Glu His Ser Ala 
        35                  40                  45              


Val Val Thr Gly Asn Asn Lys Leu Tyr Met Phe Gly Ser Asn Asn Trp 
    50                  55                  60                  


Gly Gln Leu Gly Leu Gly Ser Lys Ser Ala Ile Ser Lys Pro Thr Cys 
65                  70                  75                  80  


Val Lys Ala Leu Lys Pro Glu Lys Val Lys Leu Ala Ala Cys Gly Arg 
                85                  90                  95      


Asn His Thr Leu Val Ser Thr Glu Gly Gly Asn Val Tyr Ala Thr Gly 
            100                 105                 110         


Gly Asn Asn Glu Gly Gln Leu Gly Leu Gly Asp Thr Glu Glu Arg Asn 
        115                 120                 125             


Thr Phe His Val Ile Ser Phe Phe Thr Ser Glu His Lys Ile Lys Gln 
    130                 135                 140                 


Leu Ser Ala Gly Ser Asn Thr Ser Ala Ala Leu Thr Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Phe Met Trp Gly Asp Asn Ser Glu Gly Gln Ile Gly Leu Lys Asn 
                165                 170                 175     


Val Ser Asn Val Cys Val Pro Gln Gln Val Thr Ile Gly Lys Pro Val 
            180                 185                 190         


Ser Trp Ile Ser Cys Gly Tyr Tyr His Ser Ala Phe Val Thr Thr Asp 
        195                 200                 205             


Gly Glu Leu Tyr Val Phe Gly Glu Pro Glu Asn Gly Lys Leu Gly Leu 
    210                 215                 220                 


Pro Asn Gln Leu Leu Gly Asn His Arg Thr Pro Gln Leu Val Ser Glu 
225                 230                 235                 240 


Ile Pro Glu Lys Val Ile Gln Val Ala Cys Gly Gly Glu His Thr Val 
                245                 250                 255     


Val Leu Thr Glu Asn Ala Val Tyr Thr Phe Gly Leu Gly Gln Phe Gly 
            260                 265                 270         


Gln Leu Gly Leu Gly Thr Phe Leu Phe Glu Thr Ser Glu Pro Lys Val 
        275                 280                 285             


Ile Glu Asn Ile Arg Asp Gln Thr Ile Ser Tyr Ile Ser Cys Gly Glu 
    290                 295                 300                 


Asn His Thr Ala Leu Ile Thr Asp Ile Gly Leu Met Tyr Thr Phe Gly 
305                 310                 315                 320 


Asp Gly Arg His Gly Lys Leu Gly Leu Gly Leu Glu Asn Phe Thr Asn 
                325                 330                 335     


His Phe Ile Pro Thr Leu Cys Ser Asn Phe Leu Arg Phe Ile Val Lys 
            340                 345                 350         


Leu Val Ala Cys Gly Gly Cys His Met Val Val Phe Ala Ala Pro His 
        355                 360                 365             


Arg Gly Val Ala Lys Glu Ile Glu Phe Asp Glu Ile Asn Asp Thr Cys 
    370                 375                 380                 


Leu Ser Val Ala Thr Phe Leu Pro Tyr Ser Ser Leu Thr Ser Gly Asn 
385                 390                 395                 400 


Val Leu Gln Arg Thr Leu Ser Ala Arg Met Arg Arg Arg Glu Arg Glu 
                405                 410                 415     


Arg Ser Pro Asp Ser Phe Ser Met Arg Arg Thr Leu Pro Pro Ile Glu 
            420                 425                 430         


Gly Thr Leu Gly Leu Ser Ala Cys Phe Leu Pro Asn Ser Val Phe Pro 
        435                 440                 445             


Arg Cys Ser Glu Arg Asn Leu Gln Glu Ser Val Leu Ser Glu Gln Asp 
    450                 455                 460                 


Leu Met Gln Pro Glu Glu Pro Asp Tyr Leu Leu Asp Glu Met Thr Lys 
465                 470                 475                 480 


Glu Ala Glu Ile Asp Asn Ser Ser Thr Val Glu Ser Leu Gly Glu Thr 
                485                 490                 495     


Thr Asp Ile Leu Asn Met Thr His Ile Met Ser Leu Asn Ser Asn Glu 
            500                 505                 510         


Lys Ser Leu Lys Leu Ser Pro Val Gln Lys Gln Lys Lys Gln Gln Thr 
        515                 520                 525             


Ile Gly Glu Leu Thr Gln Asp Thr Ala Leu Thr Glu Asn Asp Asp Ser 
    530                 535                 540                 


Asp Glu Tyr Glu Glu Met Ser Glu Met Lys Glu Gly Lys Ala Cys Lys 
545                 550                 555                 560 


Gln His Val Ser Gln Gly Ile Phe Met Thr Gln Pro Ala Thr Thr Ile 
                565                 570                 575     


Glu Ala Phe Ser Asp Glu Glu Val Gly Asn Asp Thr Gly Gln Val Gly 
            580                 585                 590         


Pro Gln Ala Asp Thr Asp Gly Glu Gly Leu Gln Lys Glu Val Tyr Arg 
        595                 600                 605             


His Glu Asn Asn Asn Gly Val Asp Gln Leu Asp Ala Lys Glu Ile Glu 
    610                 615                 620                 


Lys Glu Ser Asp Gly Gly His Ser Gln Lys Glu Ser Glu Ala Glu Glu 
625                 630                 635                 640 


Ile Asp Ser Glu Lys Glu Thr Lys Leu Ala Glu Ile Ala Gly Met Lys 
                645                 650                 655     


Asp Leu Arg Glu Arg Glu Lys Ser Thr Lys Lys Met Ser Pro Phe Phe 
            660                 665                 670         


Gly Asn Leu Pro Asp Arg Gly Met Asn Thr Glu Ser Glu Glu Asn Lys 
        675                 680                 685             


Asp Phe Val Lys Lys Arg Glu Ser Cys Lys Gln Asp Val Ile Phe Asp 
    690                 695                 700                 


Ser Glu Arg Glu Ser Val Glu Lys Pro Asp Ser Tyr Met Glu Gly Ala 
705                 710                 715                 720 


Ser Glu Ser Gln Gln Gly Ile Ala Asp Gly Phe Gln Gln Pro Glu Ala 
                725                 730                 735     


Ile Glu Phe Ser Ser Gly Glu Lys Glu Asp Asp Glu Val Glu Thr Asp 
            740                 745                 750         


Gln Asn Ile Arg Tyr Gly Arg Lys Leu Ile Glu Gln Gly Asn Glu Lys 
        755                 760                 765             


Glu Thr Lys Pro Ile Ile Ser Lys Ser Met Ala Lys Tyr Asp Phe Lys 
    770                 775                 780                 


Cys Asp Arg Leu Ser Glu Ile Pro Glu Glu Lys Glu Gly Ala Glu Asp 
785                 790                 795                 800 


Ser Lys Gly Asn Gly Ile Glu Glu Gln Glu Val Glu Ala Asn Glu Glu 
                805                 810                 815     


Asn Val Lys Val His Gly Gly Arg Lys Glu Lys Thr Glu Ile Leu Ser 
            820                 825                 830         


Asp Asp Leu Thr Asp Lys Ala Glu Asp His Glu Phe Ser Lys Thr Glu 
        835                 840                 845             


Glu Leu Lys Leu Glu Asp Val Asp Glu Glu Ile Asn Ala Glu Asn Val 
    850                 855                 860                 


Glu Ser Lys Lys Lys Thr Val Gly Asp Asp Glu Ser Val Pro Thr Gly 
865                 870                 875                 880 


Tyr His Ser Lys Thr Glu Gly Ala Glu Arg Thr Asn Asp Asp Ser Ser 
                885                 890                 895     


Ala Glu Thr Ile Glu Lys Lys Glu Lys Ala Asn Leu Glu Glu Arg Ala 
            900                 905                 910         


Ile Cys Glu Tyr Asn Glu Asn Pro Lys Gly Tyr Met Leu Asp Asp Ala 
        915                 920                 925             


Asp Ser Ser Ser Leu Glu Ile Leu Glu Asn Ser Glu Thr Thr Pro Ser 
    930                 935                 940                 


Lys Asp Met Lys Lys Thr Lys Lys Ile Phe Leu Phe Lys Arg Val Pro 
945                 950                 955                 960 


Ser Ile Asn Gln Lys Ile Val Lys Asn Asn Asn Glu Pro Leu Pro Glu 
                965                 970                 975     


Ile Lys Ser Ile Gly Asp Gln Ile Ile Leu Lys Ser Asp Asn Lys Asp 
            980                 985                 990         


Ala Asp Gln Asn His Met Ser Gln  Asn His Gln Asn Ile  Pro Pro Thr 
        995                 1000                 1005             


Asn Thr  Glu Arg Arg Ser Lys  Ser Cys Thr Ile Leu  
    1010                 1015                 1020 


<210>  55
<211>  1053
<212>  DNA
<213>  Homo sapiens

<400>  55
atgggggctg gggccagtgc tgaggagaag cactccaggg agctggaaaa gaagctgaaa       60

gaggacgctg agaaggatgc tcgaaccgtg aagctgctgc ttctgggtgc cggtgagtcc      120

gggaagagca ccatcgtcaa gcagatgaag attatccacc aggacgggta ctcgctggaa      180

gagtgcctcg agtttatcgc catcatctac ggcaacacgt tgcagtccat cctggccatc      240

gtacgcgcca tgaccacact caacatccag tacggagact ctgcacgcca ggacgacgcc      300

cggaagctga tgcacatggc agacactatc gaggagggca cgatgcccaa ggagatgtcg      360

gacatcatcc agcggctgtg gaaggactcc ggtatccagg cctgttttga gcgcgcctcg      420

gagtaccagc tcaacgactc ggcgggctac tacctctccg acctggagcg cctggtaacc      480

ccgggctacg tgcccaccga gcaggacgtg ctgcgctcgc gagtcaagac cactggcatc      540

atcgagacgc agttctcctt caaggatctc aacttccgga tgttcgatgt gggcgggcag      600

cgctcggagc gcaagaagtg gatccactgc ttcgagggcg tgacctgcat catcttcatc      660

gcggcgctga gcgcctacga catggtgcta gtggaggacg acgaagtgaa ccgcatgcac      720

gagagcctgc acctgttcaa cagcatctgc aaccaccgct acttcgccac gacgtccatc      780

gtgctcttcc ttaacaagaa ggacgtcttc ttcgagaaga tcaagaaggc gcacctcagc      840

atctgtttcc cggactacga tggacccaac acctacgagg acgccggcaa ctacatcaag      900

gtgcagttcc tcgagctcaa catgcggcgc gacgtgaagg agatctattc ccacatgacg      960

tgcgccaccg acacgcagaa cgtcaaattt gtcttcgacg ctgtcaccga catcatcatc     1020

aaggagaacc tcaaagactg tggcctcttc tga                                  1053


<210>  56
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Gly Ala Gly Ala Ser Ala Glu Glu Lys His Ser Arg Glu Leu Glu 
1               5                   10                  15      


Lys Lys Leu Lys Glu Asp Ala Glu Lys Asp Ala Arg Thr Val Lys Leu 
            20                  25                  30          


Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln 
        35                  40                  45              


Met Lys Ile Ile His Gln Asp Gly Tyr Ser Leu Glu Glu Cys Leu Glu 
    50                  55                  60                  


Phe Ile Ala Ile Ile Tyr Gly Asn Thr Leu Gln Ser Ile Leu Ala Ile 
65                  70                  75                  80  


Val Arg Ala Met Thr Thr Leu Asn Ile Gln Tyr Gly Asp Ser Ala Arg 
                85                  90                  95      


Gln Asp Asp Ala Arg Lys Leu Met His Met Ala Asp Thr Ile Glu Glu 
            100                 105                 110         


Gly Thr Met Pro Lys Glu Met Ser Asp Ile Ile Gln Arg Leu Trp Lys 
        115                 120                 125             


Asp Ser Gly Ile Gln Ala Cys Phe Glu Arg Ala Ser Glu Tyr Gln Leu 
    130                 135                 140                 


Asn Asp Ser Ala Gly Tyr Tyr Leu Ser Asp Leu Glu Arg Leu Val Thr 
145                 150                 155                 160 


Pro Gly Tyr Val Pro Thr Glu Gln Asp Val Leu Arg Ser Arg Val Lys 
                165                 170                 175     


Thr Thr Gly Ile Ile Glu Thr Gln Phe Ser Phe Lys Asp Leu Asn Phe 
            180                 185                 190         


Arg Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg Lys Lys Trp Ile 
        195                 200                 205             


His Cys Phe Glu Gly Val Thr Cys Ile Ile Phe Ile Ala Ala Leu Ser 
    210                 215                 220                 


Ala Tyr Asp Met Val Leu Val Glu Asp Asp Glu Val Asn Arg Met His 
225                 230                 235                 240 


Glu Ser Leu His Leu Phe Asn Ser Ile Cys Asn His Arg Tyr Phe Ala 
                245                 250                 255     


Thr Thr Ser Ile Val Leu Phe Leu Asn Lys Lys Asp Val Phe Phe Glu 
            260                 265                 270         


Lys Ile Lys Lys Ala His Leu Ser Ile Cys Phe Pro Asp Tyr Asp Gly 
        275                 280                 285             


Pro Asn Thr Tyr Glu Asp Ala Gly Asn Tyr Ile Lys Val Gln Phe Leu 
    290                 295                 300                 


Glu Leu Asn Met Arg Arg Asp Val Lys Glu Ile Tyr Ser His Met Thr 
305                 310                 315                 320 


Cys Ala Thr Asp Thr Gln Asn Val Lys Phe Val Phe Asp Ala Val Thr 
                325                 330                 335     


Asp Ile Ile Ile Lys Glu Asn Leu Lys Asp Cys Gly Leu Phe 
            340                 345                 350 


<210>  57
<211>  2583
<212>  DNA
<213>  Homo sapiens

<400>  57
atgggcgagg tgacagcaga ggaggtggag aagttcctgg actcgaatat tggctttgcc       60

aaacagtact acaacctcca ctaccgggcc aagctcatct ccgacctcct tggggccaag      120

gaggctgccg tggacttcag caactaccac tccccgagca gcatggagga gagcgaaatc      180

atctttgatc tcctgcggga ctttcaggag aatttacaga cagagaaatg catcttcaat      240

gtcatgaaga agctgtgctt cctcctgcag gcagaccgca tgagcctgtt catgtaccgg      300

acccgcaatg gcatcgcaga gctggccacc aggcttttca atgtccacaa ggatgctgtc      360

ctcgaggact gcctggtgat gcccgaccaa gagatcgtct tccctttgga catgggcatc      420

gtgggccatg tcgcacactc taagaagatt gctaacgtcc ccaacacaga ggaggatgag      480

catttctgtg actttgtgga catcctcaca gagtacaaga ccaagaacat cttggcttcc      540

cccataatga atgggaagga tgtggtggcc ataatcatgg ctgtgaataa agtggatgga      600

tcccacttca ccaagagaga tgaagagatt cttctcaagt acctcaattt tgcaaatcta      660

atcatgaagg tgtaccacct gagttacctg cacaactgtg aaactcgacg tggccagata      720

ctgctgtggt ctgggagcaa agtctttgaa gaacttacgg acatcgaacg acagttccac      780

aaagccctgt acacagtccg tgctttcctc aactgtgaca gatactctgt gggtctctta      840

gacatgacca agcagaagga attttttgat gtgtggccgg ttctgatggg tgaagttcca      900

ccttactctg gtcccaggac tccggatgga agagaaatta acttttacaa ggtcattgac      960

tacatcctgc atggcaaaga ggacatcaaa gtcatcccga atccacctcc tgaccattgg     1020

gctttagtaa gcggtctccc agcttatgtt gcccagaatg gcctgatttg caacatcatg     1080

aatgcgcctg cggaggactt ttttgcattt cagaaagaac ctctggatga gtctggatgg     1140

atgattaaaa atgtgctttc aatgccgatt gtgaacaaga aggaagaaat tgttggagtg     1200

gccacatttt acaatcgtaa agatgggaag ccctttgatg aaatggatga gacgctcatg     1260

gagtctttga ctcaatttct gggctggtct gtcttaaatc ctgacaccta tgagtcaatg     1320

aataaacttg aaaataggaa ggatattttc caggacatag taaaatatca tgtgaagtgt     1380

gacaatgaag aaattcagaa aatcttgaaa accagagagg tgtatgggaa ggagccatgg     1440

gagtgtgagg aagaggagct ggctgagatc ctgcaagcgg agctgccaga tgcagataaa     1500

tacgaaatta ataaatttca cttcagtgac ttacccctaa cagaactgga gctggtaaaa     1560

tgtggaatac agatgtatta tgagctcaaa gtggtggata aatttcacat tccacaagag     1620

gccctggtgc ggttcatgta ctccctgagt aagggctacc gcaagatcac ctaccacaac     1680

tggcggcacg gcttcaacgt ggggcagacc atgttctccc tgctggtgac gggaaagctg     1740

aagcgctact tcacggacct agaggccttg gccatggtca ctgctgcttt ctgccatgac     1800

attgaccaca gaggcaccaa taacctctac cagatgaaat cccagaaccc actggccaag     1860

ctccatgggt cctctatctt ggaaagacac cacttggagt ttggcaaaac actgctcaga     1920

gacgagagcc tgaatatctt tcaaaacctc aatcgtcgac agcatgagca tgccatccac     1980

atgatggaca ttgcaatcat tgccacagac ctcgccctgt atttcaagaa gaggacgatg     2040

ttccaaaaga tcgtggatca gtctaagaca tatgagagtg aacaggagtg gacacagtac     2100

atgatgctgg agcagacacg gaaggaaatc gttatggcca tgatgatgac cgcctgtgat     2160

ctctcagcca tcaccaaacc ctgggaggtg cagagccagg tagctctgct ggtggctgct     2220

gaattctggg aacaaggtga cctggagcgc acggtgctgc aacagaatcc cattcccatg     2280

atggacagaa acaaagcaga tgaactccct aagcttcaag tcggcttcat tgactttgtt     2340

tgcaccttcg tctacaagga attctcccgt ttccacgagg agatcacccc aatgttggac     2400

gggatcacca acaatcgcaa ggagtggaag gcgcttgctg atgagtacga tgccaagatg     2460

aaggtgcagg aggagaagaa gcagaaacag cagtcggcca agtcagcagc cgcaggaaat     2520

cagccggggg gaaaccccag cccagggggt gcaactacat ccaagtcctg ctgcatccag     2580

taa                                                                   2583


<210>  58
<211>  860
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Gly Glu Val Thr Ala Glu Glu Val Glu Lys Phe Leu Asp Ser Asn 
1               5                   10                  15      


Ile Gly Phe Ala Lys Gln Tyr Tyr Asn Leu His Tyr Arg Ala Lys Leu 
            20                  25                  30          


Ile Ser Asp Leu Leu Gly Ala Lys Glu Ala Ala Val Asp Phe Ser Asn 
        35                  40                  45              


Tyr His Ser Pro Ser Ser Met Glu Glu Ser Glu Ile Ile Phe Asp Leu 
    50                  55                  60                  


Leu Arg Asp Phe Gln Glu Asn Leu Gln Thr Glu Lys Cys Ile Phe Asn 
65                  70                  75                  80  


Val Met Lys Lys Leu Cys Phe Leu Leu Gln Ala Asp Arg Met Ser Leu 
                85                  90                  95      


Phe Met Tyr Arg Thr Arg Asn Gly Ile Ala Glu Leu Ala Thr Arg Leu 
            100                 105                 110         


Phe Asn Val His Lys Asp Ala Val Leu Glu Asp Cys Leu Val Met Pro 
        115                 120                 125             


Asp Gln Glu Ile Val Phe Pro Leu Asp Met Gly Ile Val Gly His Val 
    130                 135                 140                 


Ala His Ser Lys Lys Ile Ala Asn Val Pro Asn Thr Glu Glu Asp Glu 
145                 150                 155                 160 


His Phe Cys Asp Phe Val Asp Ile Leu Thr Glu Tyr Lys Thr Lys Asn 
                165                 170                 175     


Ile Leu Ala Ser Pro Ile Met Asn Gly Lys Asp Val Val Ala Ile Ile 
            180                 185                 190         


Met Ala Val Asn Lys Val Asp Gly Ser His Phe Thr Lys Arg Asp Glu 
        195                 200                 205             


Glu Ile Leu Leu Lys Tyr Leu Asn Phe Ala Asn Leu Ile Met Lys Val 
    210                 215                 220                 


Tyr His Leu Ser Tyr Leu His Asn Cys Glu Thr Arg Arg Gly Gln Ile 
225                 230                 235                 240 


Leu Leu Trp Ser Gly Ser Lys Val Phe Glu Glu Leu Thr Asp Ile Glu 
                245                 250                 255     


Arg Gln Phe His Lys Ala Leu Tyr Thr Val Arg Ala Phe Leu Asn Cys 
            260                 265                 270         


Asp Arg Tyr Ser Val Gly Leu Leu Asp Met Thr Lys Gln Lys Glu Phe 
        275                 280                 285             


Phe Asp Val Trp Pro Val Leu Met Gly Glu Val Pro Pro Tyr Ser Gly 
    290                 295                 300                 


Pro Arg Thr Pro Asp Gly Arg Glu Ile Asn Phe Tyr Lys Val Ile Asp 
305                 310                 315                 320 


Tyr Ile Leu His Gly Lys Glu Asp Ile Lys Val Ile Pro Asn Pro Pro 
                325                 330                 335     


Pro Asp His Trp Ala Leu Val Ser Gly Leu Pro Ala Tyr Val Ala Gln 
            340                 345                 350         


Asn Gly Leu Ile Cys Asn Ile Met Asn Ala Pro Ala Glu Asp Phe Phe 
        355                 360                 365             


Ala Phe Gln Lys Glu Pro Leu Asp Glu Ser Gly Trp Met Ile Lys Asn 
    370                 375                 380                 


Val Leu Ser Met Pro Ile Val Asn Lys Lys Glu Glu Ile Val Gly Val 
385                 390                 395                 400 


Ala Thr Phe Tyr Asn Arg Lys Asp Gly Lys Pro Phe Asp Glu Met Asp 
                405                 410                 415     


Glu Thr Leu Met Glu Ser Leu Thr Gln Phe Leu Gly Trp Ser Val Leu 
            420                 425                 430         


Asn Pro Asp Thr Tyr Glu Ser Met Asn Lys Leu Glu Asn Arg Lys Asp 
        435                 440                 445             


Ile Phe Gln Asp Ile Val Lys Tyr His Val Lys Cys Asp Asn Glu Glu 
    450                 455                 460                 


Ile Gln Lys Ile Leu Lys Thr Arg Glu Val Tyr Gly Lys Glu Pro Trp 
465                 470                 475                 480 


Glu Cys Glu Glu Glu Glu Leu Ala Glu Ile Leu Gln Ala Glu Leu Pro 
                485                 490                 495     


Asp Ala Asp Lys Tyr Glu Ile Asn Lys Phe His Phe Ser Asp Leu Pro 
            500                 505                 510         


Leu Thr Glu Leu Glu Leu Val Lys Cys Gly Ile Gln Met Tyr Tyr Glu 
        515                 520                 525             


Leu Lys Val Val Asp Lys Phe His Ile Pro Gln Glu Ala Leu Val Arg 
    530                 535                 540                 


Phe Met Tyr Ser Leu Ser Lys Gly Tyr Arg Lys Ile Thr Tyr His Asn 
545                 550                 555                 560 


Trp Arg His Gly Phe Asn Val Gly Gln Thr Met Phe Ser Leu Leu Val 
                565                 570                 575     


Thr Gly Lys Leu Lys Arg Tyr Phe Thr Asp Leu Glu Ala Leu Ala Met 
            580                 585                 590         


Val Thr Ala Ala Phe Cys His Asp Ile Asp His Arg Gly Thr Asn Asn 
        595                 600                 605             


Leu Tyr Gln Met Lys Ser Gln Asn Pro Leu Ala Lys Leu His Gly Ser 
    610                 615                 620                 


Ser Ile Leu Glu Arg His His Leu Glu Phe Gly Lys Thr Leu Leu Arg 
625                 630                 635                 640 


Asp Glu Ser Leu Asn Ile Phe Gln Asn Leu Asn Arg Arg Gln His Glu 
                645                 650                 655     


His Ala Ile His Met Met Asp Ile Ala Ile Ile Ala Thr Asp Leu Ala 
            660                 665                 670         


Leu Tyr Phe Lys Lys Arg Thr Met Phe Gln Lys Ile Val Asp Gln Ser 
        675                 680                 685             


Lys Thr Tyr Glu Ser Glu Gln Glu Trp Thr Gln Tyr Met Met Leu Glu 
    690                 695                 700                 


Gln Thr Arg Lys Glu Ile Val Met Ala Met Met Met Thr Ala Cys Asp 
705                 710                 715                 720 


Leu Ser Ala Ile Thr Lys Pro Trp Glu Val Gln Ser Gln Val Ala Leu 
                725                 730                 735     


Leu Val Ala Ala Glu Phe Trp Glu Gln Gly Asp Leu Glu Arg Thr Val 
            740                 745                 750         


Leu Gln Gln Asn Pro Ile Pro Met Met Asp Arg Asn Lys Ala Asp Glu 
        755                 760                 765             


Leu Pro Lys Leu Gln Val Gly Phe Ile Asp Phe Val Cys Thr Phe Val 
    770                 775                 780                 


Tyr Lys Glu Phe Ser Arg Phe His Glu Glu Ile Thr Pro Met Leu Asp 
785                 790                 795                 800 


Gly Ile Thr Asn Asn Arg Lys Glu Trp Lys Ala Leu Ala Asp Glu Tyr 
                805                 810                 815     


Asp Ala Lys Met Lys Val Gln Glu Glu Lys Lys Gln Lys Gln Gln Ser 
            820                 825                 830         


Ala Lys Ser Ala Ala Ala Gly Asn Gln Pro Gly Gly Asn Pro Ser Pro 
        835                 840                 845             


Gly Gly Ala Thr Thr Ser Lys Ser Cys Cys Ile Gln 
    850                 855                 860 


<210>  59
<211>  2565
<212>  DNA
<213>  Homo sapiens

<400>  59
atgagcctca gtgaggagca ggcccggagc tttctggacc agaaccccga ttttgcccgc       60

cagtactttg ggaagaaact gagccctgag aatgtggccg cggcctgcga ggacgggtgc      120

ccgccggact gcgacagcct ccgggacctc tgccaggtgg aggagagcac ggcgctgctg      180

gagctggtgc aggatatgca ggagagcatc aacatggagc gcgtggtctt caaggtcctg      240

cggcgcctct gcaccctcct gcaggccgac cgctgcagcc tcttcatgta ccgccagcgc      300

aacggcgtgg ccgagctggc caccaggctt ttcagcgtgc agccggacag cgtcctggag      360

gactgcctgg tgccccccga ctccgagatc gtcttcccac tggacatcgg ggtcgtgggc      420

cacgtggctc agaccaaaaa gatggtgaac gtcgaggacg tggccgagtg ccctcacttc      480

agctcatttg ctgacgagct cactgactac aagacaaaga atatgctggc cacacccatc      540

atgaatggca aagacgtcgt ggcggtgatc atggcagtga acaagctcaa cggcccattc      600

ttcaccagcg aagacgaaga tgtgttcttg aagtacctga attttgccac gttgtacctg      660

aagatctatc acctgagcta cctccacaac tgcgagacgc gccgcggcca ggtgctgctg      720

tggtcggcca acaaggtgtt tgaggagctg acggacatcg agaggcagtt ccacaaggcc      780

ttctacacgg tgcgggccta cctcaactgc gagcggtact ccgtgggcct cctggacatg      840

accaaggaga aggaattttt tgacgtgtgg tctgtgctga tgggagagtc ccagccgtac      900

tcgggcccac gcacgcctga tggccgggaa attgtcttct acaaagtgat cgactacgtc      960

ctccacggca aggaggagat caaggtcatt cccacaccct cagccgatca ctgggccctg     1020

gccagcggcc ttccaagcta cgtggcagaa agcggcttta tttgtaacat catgaatgct     1080

tccgctgacg aaatgttcaa atttcaggaa ggggccctgg acgactccgg gtggctcatc     1140

aagaatgtgc tgtccatgcc catcgtcaac aagaaggagg agattgtggg agtcgccaca     1200

ttttacaaca ggaaagacgg gaagcccttt gacgaacagg acgaggttct catggagtcc     1260

ctgacacagt tcctgggctg gtcagtgatg aacaccgaca cctacgacaa gatgaacaag     1320

ctggagaacc gcaaggacat cgcacaggac atggtccttt accacgtgaa gtgcgacagg     1380

gacgagatcc agctcatcct gccaaccaga gcgcgcctgg ggaaggagcc tgctgactgc     1440

gatgaggacg agctgggcga aatcctgaag gaggagctgc cagggcccac cacatttgac     1500

atctacgaat tccacttctc tgacctggag tgcaccgaac tggacctggt caaatgtggc     1560

atccagatgt actacgagct gggcgtggtc cgaaagttcc agatccccca ggaggtcctg     1620

gtgcggttcc tgttctccat cagcaaaggg taccggagaa tcacctacca caactggcgc     1680

cacggcttca acgtggccca gacgatgttc acgctgctca tgaccggcaa actgaagagc     1740

tactacacgg acctggaggc cttcgccatg gtgacagccg gcctgtgcca tgacatcgac     1800

caccgcggca ccaacaacct gtaccagatg aagtcccaga accccttggc taagctccac     1860

ggctcctcga ttttggagcg gcaccacctg gagtttggga agttcctgct ctcggaggag     1920

accctgaaca tctaccagaa cctgaaccgg cggcagcacg agcacgtgat ccacctgatg     1980

gacatcgcca tcatcgccac ggacctggcc ctgtacttca agaagagagc gatgtttcag     2040

aagatcgtgg atgagtccaa gaactaccag gacaagaaga gctgggtgga gtacctgtcc     2100

ctggagacga cccggaagga gatcgtcatg gccatgatga tgacagcctg cgacctgtct     2160

gccatcacca agccctggga agtccagagc aaggtcgcac ttctcgtggc tgctgagttc     2220

tgggagcaag gtgacttgga aaggacagtc ttggatcagc agcccattcc tatgatggac     2280

cggaacaagg cggccgagct ccccaagctg caagtgggct tcatcgactt cgtgtgcaca     2340

ttcgtgtaca aggagttctc tcgtttccac gaagagatcc tgcccatgtt cgaccgactg     2400

cagaacaata ggaaagagtg gaaggcgctg gctgatgagt atgaggccaa agtgaaggct     2460

ctggaggaga aggaggagga ggagagggtg gcagccaaga aagtaggcac agaaatttgc     2520

aatggcggcc cagcacccaa gtcttcaacc tgctgtatcc tgtga                     2565


<210>  60
<211>  854
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ser Leu Ser Glu Glu Gln Ala Arg Ser Phe Leu Asp Gln Asn Pro 
1               5                   10                  15      


Asp Phe Ala Arg Gln Tyr Phe Gly Lys Lys Leu Ser Pro Glu Asn Val 
            20                  25                  30          


Ala Ala Ala Cys Glu Asp Gly Cys Pro Pro Asp Cys Asp Ser Leu Arg 
        35                  40                  45              


Asp Leu Cys Gln Val Glu Glu Ser Thr Ala Leu Leu Glu Leu Val Gln 
    50                  55                  60                  


Asp Met Gln Glu Ser Ile Asn Met Glu Arg Val Val Phe Lys Val Leu 
65                  70                  75                  80  


Arg Arg Leu Cys Thr Leu Leu Gln Ala Asp Arg Cys Ser Leu Phe Met 
                85                  90                  95      


Tyr Arg Gln Arg Asn Gly Val Ala Glu Leu Ala Thr Arg Leu Phe Ser 
            100                 105                 110         


Val Gln Pro Asp Ser Val Leu Glu Asp Cys Leu Val Pro Pro Asp Ser 
        115                 120                 125             


Glu Ile Val Phe Pro Leu Asp Ile Gly Val Val Gly His Val Ala Gln 
    130                 135                 140                 


Thr Lys Lys Met Val Asn Val Glu Asp Val Ala Glu Cys Pro His Phe 
145                 150                 155                 160 


Ser Ser Phe Ala Asp Glu Leu Thr Asp Tyr Lys Thr Lys Asn Met Leu 
                165                 170                 175     


Ala Thr Pro Ile Met Asn Gly Lys Asp Val Val Ala Val Ile Met Ala 
            180                 185                 190         


Val Asn Lys Leu Asn Gly Pro Phe Phe Thr Ser Glu Asp Glu Asp Val 
        195                 200                 205             


Phe Leu Lys Tyr Leu Asn Phe Ala Thr Leu Tyr Leu Lys Ile Tyr His 
    210                 215                 220                 


Leu Ser Tyr Leu His Asn Cys Glu Thr Arg Arg Gly Gln Val Leu Leu 
225                 230                 235                 240 


Trp Ser Ala Asn Lys Val Phe Glu Glu Leu Thr Asp Ile Glu Arg Gln 
                245                 250                 255     


Phe His Lys Ala Phe Tyr Thr Val Arg Ala Tyr Leu Asn Cys Glu Arg 
            260                 265                 270         


Tyr Ser Val Gly Leu Leu Asp Met Thr Lys Glu Lys Glu Phe Phe Asp 
        275                 280                 285             


Val Trp Ser Val Leu Met Gly Glu Ser Gln Pro Tyr Ser Gly Pro Arg 
    290                 295                 300                 


Thr Pro Asp Gly Arg Glu Ile Val Phe Tyr Lys Val Ile Asp Tyr Val 
305                 310                 315                 320 


Leu His Gly Lys Glu Glu Ile Lys Val Ile Pro Thr Pro Ser Ala Asp 
                325                 330                 335     


His Trp Ala Leu Ala Ser Gly Leu Pro Ser Tyr Val Ala Glu Ser Gly 
            340                 345                 350         


Phe Ile Cys Asn Ile Met Asn Ala Ser Ala Asp Glu Met Phe Lys Phe 
        355                 360                 365             


Gln Glu Gly Ala Leu Asp Asp Ser Gly Trp Leu Ile Lys Asn Val Leu 
    370                 375                 380                 


Ser Met Pro Ile Val Asn Lys Lys Glu Glu Ile Val Gly Val Ala Thr 
385                 390                 395                 400 


Phe Tyr Asn Arg Lys Asp Gly Lys Pro Phe Asp Glu Gln Asp Glu Val 
                405                 410                 415     


Leu Met Glu Ser Leu Thr Gln Phe Leu Gly Trp Ser Val Met Asn Thr 
            420                 425                 430         


Asp Thr Tyr Asp Lys Met Asn Lys Leu Glu Asn Arg Lys Asp Ile Ala 
        435                 440                 445             


Gln Asp Met Val Leu Tyr His Val Lys Cys Asp Arg Asp Glu Ile Gln 
    450                 455                 460                 


Leu Ile Leu Pro Thr Arg Ala Arg Leu Gly Lys Glu Pro Ala Asp Cys 
465                 470                 475                 480 


Asp Glu Asp Glu Leu Gly Glu Ile Leu Lys Glu Glu Leu Pro Gly Pro 
                485                 490                 495     


Thr Thr Phe Asp Ile Tyr Glu Phe His Phe Ser Asp Leu Glu Cys Thr 
            500                 505                 510         


Glu Leu Asp Leu Val Lys Cys Gly Ile Gln Met Tyr Tyr Glu Leu Gly 
        515                 520                 525             


Val Val Arg Lys Phe Gln Ile Pro Gln Glu Val Leu Val Arg Phe Leu 
    530                 535                 540                 


Phe Ser Ile Ser Lys Gly Tyr Arg Arg Ile Thr Tyr His Asn Trp Arg 
545                 550                 555                 560 


His Gly Phe Asn Val Ala Gln Thr Met Phe Thr Leu Leu Met Thr Gly 
                565                 570                 575     


Lys Leu Lys Ser Tyr Tyr Thr Asp Leu Glu Ala Phe Ala Met Val Thr 
            580                 585                 590         


Ala Gly Leu Cys His Asp Ile Asp His Arg Gly Thr Asn Asn Leu Tyr 
        595                 600                 605             


Gln Met Lys Ser Gln Asn Pro Leu Ala Lys Leu His Gly Ser Ser Ile 
    610                 615                 620                 


Leu Glu Arg His His Leu Glu Phe Gly Lys Phe Leu Leu Ser Glu Glu 
625                 630                 635                 640 


Thr Leu Asn Ile Tyr Gln Asn Leu Asn Arg Arg Gln His Glu His Val 
                645                 650                 655     


Ile His Leu Met Asp Ile Ala Ile Ile Ala Thr Asp Leu Ala Leu Tyr 
            660                 665                 670         


Phe Lys Lys Arg Ala Met Phe Gln Lys Ile Val Asp Glu Ser Lys Asn 
        675                 680                 685             


Tyr Gln Asp Lys Lys Ser Trp Val Glu Tyr Leu Ser Leu Glu Thr Thr 
    690                 695                 700                 


Arg Lys Glu Ile Val Met Ala Met Met Met Thr Ala Cys Asp Leu Ser 
705                 710                 715                 720 


Ala Ile Thr Lys Pro Trp Glu Val Gln Ser Lys Val Ala Leu Leu Val 
                725                 730                 735     


Ala Ala Glu Phe Trp Glu Gln Gly Asp Leu Glu Arg Thr Val Leu Asp 
            740                 745                 750         


Gln Gln Pro Ile Pro Met Met Asp Arg Asn Lys Ala Ala Glu Leu Pro 
        755                 760                 765             


Lys Leu Gln Val Gly Phe Ile Asp Phe Val Cys Thr Phe Val Tyr Lys 
    770                 775                 780                 


Glu Phe Ser Arg Phe His Glu Glu Ile Leu Pro Met Phe Asp Arg Leu 
785                 790                 795                 800 


Gln Asn Asn Arg Lys Glu Trp Lys Ala Leu Ala Asp Glu Tyr Glu Ala 
                805                 810                 815     


Lys Val Lys Ala Leu Glu Glu Lys Glu Glu Glu Glu Arg Val Ala Ala 
            820                 825                 830         


Lys Lys Val Gly Thr Glu Ile Cys Asn Gly Gly Pro Ala Pro Lys Ser 
        835                 840                 845             


Ser Thr Cys Cys Ile Leu 
    850                 


<210>  61
<211>  2166
<212>  DNA
<213>  Homo sapiens

<400>  61
atgctgctgc ctgtgttcac cctgaaactg cgccacaaaa tcagcccccg aatggtggcc       60

atagggcgct acgacgggac tcacccgtgc ctggcggccg ccacccaaac gggcaaggtt      120

tttattcata atcctcatac acggaaccag catgtcagtg catccagggt cttccagagc      180

cccctggaat ctgatgtttc tcttctcagc attaaccagg cagtcagctg tctgactgca      240

ggcgtattga accctgagct tggctatgat gcccttttag tggggacaca gactaatctt      300

ttggcttatg atgtctacaa taattcggat ttgttctaca gagaggtagc agatggggca      360

aatgcaattg tgctggggac attgggagac atttcttccc ctcttgcgat tattggtggc      420

aattgtgctc tgcaaggttt caatcatgaa ggaagtgatc tcttttggac ggttactgga      480

gacaatgtta attccttggc cttgtgtgac tttgatggtg atggaaagaa agagcttctt      540

gttggatctg aggattttga tatccgagtt tttaaggaag atgagattgt ggcagaaatg      600

acagaaacag agatagtcac ctctctttgt cccatgtatg gcagtcgatt tggttatgcc      660

ctttccaatg gcacagttgg agtttatgac aaaacatccc gatactggag aattaaatcg      720

aaaaatcatg ccatgagcat tcatgctttt gaccttaatt ctgatggagt gaatgaactg      780

ataactggtt ggtccaatgg gaaggttgat gctcgaagtg accgaactgg ggaggtcatc      840

tttaaggaca atttttcttc tgcaattgcc ggtgtggtag agggagatta ccggatggat      900

ggccacatac agttaatctg ctgctcagtg gatggggaaa tccggggcta cctgcctggc      960

acggctgaga tgaggggcaa cctcatggac accagtgcag agcaggacct gatccgagag     1020

ctgagtcaga agaagcagaa tctgttgctg gaactccgta actatgagga aaatgccaag     1080

gctgaattgg ccagtccact gaacgaggct gatgggcatc ggggcataat cccagccaat     1140

accaggctcc acaccacgct ctcagtcagc ctggggaatg agacccaaac tgctcataca     1200

gaattacgca tttccacttc taatgacacc atcatccgag cagtattgat ttttgcagaa     1260

ggaattttta caggtgaaag ccacgtggta catcccagca ttcacaacct ctccagttcc     1320

atctgcatcc ctattgtgcc tcccaaagat gtccctgtgg atctgcactt gaaggcattc     1380

gtgggttaca gaagcagcac ccagtttcat gtatttgaat cgacaagaca gctccctcga     1440

ttctccatgt atgcgctgac cagcctggac cctgccagtg agccaatcag ttatgttaac     1500

tttaccattg cagaacgggc acagagggtt gttgtatggc tcggtcagaa ctttctgtta     1560

ccagaagaca ctcacattca gaatgctcca tttcaagtgt gtttcacatc tttacggaat     1620

ggcggccacc tgcatataaa aataaaactt agtggagaga tcactataaa tactgatgat     1680

attgatttgg ctggtgatat catccagtca atggcatcat tttttgctat tgaagacctt     1740

caagtagaag cggattttcc tgtctatttt gaggaattac gaaaggtgct agttaaggtg     1800

gatgaatatc attcagtgca tcagaagctc agtgctgata tggctgatca ttctaatttg     1860

atccgaagtt tgctggtcgg agctgaggat gctcgtctga tgagggacat gaaaacaatg     1920

aagagtcgtt atatggaact ctatgacctt aatagagact tgctaaatgg atataaaatt     1980

cgctgtaaca atcacacaga gctgttggga aacctcaaag cagtaaatca agcaattcaa     2040

agagcaggtc gtctgcgggt tggaaaacca aagaaccagg tgatcactgc ttgtcgggat     2100

gcaattcgaa gcaataacat caacacactg ttcaaaatca tgcgagtggg gacagcttct     2160

tcctag                                                                2166


<210>  62
<211>  721
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Leu Leu Pro Val Phe Thr Leu Lys Leu Arg His Lys Ile Ser Pro 
1               5                   10                  15      


Arg Met Val Ala Ile Gly Arg Tyr Asp Gly Thr His Pro Cys Leu Ala 
            20                  25                  30          


Ala Ala Thr Gln Thr Gly Lys Val Phe Ile His Asn Pro His Thr Arg 
        35                  40                  45              


Asn Gln His Val Ser Ala Ser Arg Val Phe Gln Ser Pro Leu Glu Ser 
    50                  55                  60                  


Asp Val Ser Leu Leu Asn Ile Asn Gln Ala Val Ser Cys Leu Thr Ala 
65                  70                  75                  80  


Gly Val Leu Asn Pro Glu Leu Gly Tyr Asp Ala Leu Leu Val Gly Thr 
                85                  90                  95      


Gln Thr Asn Leu Leu Ala Tyr Asp Val Tyr Asn Asn Ser Asp Leu Phe 
            100                 105                 110         


Tyr Arg Glu Val Ala Asp Gly Ala Asn Ala Ile Val Leu Gly Thr Leu 
        115                 120                 125             


Gly Asp Ile Ser Ser Pro Leu Ala Ile Ile Gly Gly Asn Cys Ala Leu 
    130                 135                 140                 


Gln Gly Phe Asn His Glu Gly Ser Asp Leu Phe Trp Thr Val Thr Gly 
145                 150                 155                 160 


Asp Asn Val Asn Ser Leu Ala Leu Cys Asp Phe Asp Gly Asp Gly Lys 
                165                 170                 175     


Lys Glu Leu Leu Val Gly Ser Glu Asp Phe Asp Ile Arg Val Phe Lys 
            180                 185                 190         


Glu Asp Glu Ile Val Ala Glu Met Thr Glu Thr Glu Ile Val Thr Ser 
        195                 200                 205             


Leu Cys Pro Met Tyr Gly Ser Arg Phe Gly Tyr Ala Leu Ser Asn Gly 
    210                 215                 220                 


Thr Val Gly Val Tyr Asp Lys Thr Ser Arg Tyr Trp Arg Ile Lys Ser 
225                 230                 235                 240 


Lys Asn His Ala Met Ser Ile His Ala Phe Asp Leu Asn Ser Asp Gly 
                245                 250                 255     


Val Asn Glu Leu Ile Thr Gly Trp Ser Asn Gly Lys Val Asp Ala Arg 
            260                 265                 270         


Ser Asp Arg Thr Gly Glu Val Ile Phe Lys Asp Asn Phe Ser Ser Ala 
        275                 280                 285             


Ile Ala Gly Val Val Glu Gly Asp Tyr Arg Met Asp Gly His Ile Gln 
    290                 295                 300                 


Leu Ile Cys Cys Ser Val Asp Gly Glu Ile Arg Gly Tyr Leu Pro Gly 
305                 310                 315                 320 


Thr Ala Glu Met Arg Gly Asn Leu Met Asp Thr Ser Ala Glu Gln Asp 
                325                 330                 335     


Leu Ile Arg Glu Leu Ser Gln Lys Lys Gln Asn Leu Leu Leu Glu Leu 
            340                 345                 350         


Arg Asn Tyr Glu Glu Asn Ala Lys Ala Glu Leu Ala Ser Pro Leu Asn 
        355                 360                 365             


Glu Ala Asp Gly His Arg Gly Ile Ile Pro Ala Asn Thr Arg Leu His 
    370                 375                 380                 


Thr Thr Leu Ser Val Ser Leu Gly Asn Glu Thr Gln Thr Ala His Thr 
385                 390                 395                 400 


Glu Leu Arg Ile Ser Thr Ser Asn Asp Thr Ile Ile Arg Ala Val Leu 
                405                 410                 415     


Ile Phe Ala Glu Gly Ile Phe Thr Gly Glu Ser His Val Val His Pro 
            420                 425                 430         


Ser Ile His Asn Leu Ser Ser Ser Ile Cys Ile Pro Ile Val Pro Pro 
        435                 440                 445             


Lys Asp Val Pro Val Asp Leu His Leu Lys Ala Phe Val Gly Tyr Arg 
    450                 455                 460                 


Ser Ser Thr Gln Phe His Val Phe Glu Ser Thr Arg Gln Leu Pro Arg 
465                 470                 475                 480 


Phe Ser Met Tyr Ala Leu Thr Ser Leu Asp Pro Ala Ser Glu Pro Ile 
                485                 490                 495     


Ser Tyr Val Asn Phe Thr Ile Ala Glu Arg Ala Gln Arg Val Val Val 
            500                 505                 510         


Trp Leu Gly Gln Asn Phe Leu Leu Pro Glu Asp Thr His Ile Gln Asn 
        515                 520                 525             


Ala Pro Phe Gln Val Cys Phe Thr Ser Leu Arg Asn Gly Gly His Leu 
    530                 535                 540                 


His Ile Lys Ile Lys Leu Ser Gly Glu Ile Thr Ile Asn Thr Asp Asp 
545                 550                 555                 560 


Ile Asp Leu Ala Gly Asp Ile Ile Gln Ser Met Ala Ser Phe Phe Ala 
                565                 570                 575     


Ile Glu Asp Leu Gln Val Glu Ala Asp Phe Pro Val Tyr Phe Glu Glu 
            580                 585                 590         


Leu Arg Lys Val Leu Val Lys Val Asp Glu Tyr His Ser Val His Gln 
        595                 600                 605             


Lys Leu Ser Ala Asp Met Ala Asp His Ser Asn Leu Ile Arg Ser Leu 
    610                 615                 620                 


Leu Val Gly Ala Glu Asp Ala Arg Leu Met Arg Asp Met Lys Thr Met 
625                 630                 635                 640 


Lys Ser Arg Tyr Met Glu Leu Tyr Asp Leu Asn Arg Asp Leu Leu Asn 
                645                 650                 655     


Gly Tyr Lys Ile Arg Cys Asn Asn His Thr Glu Leu Leu Gly Asn Leu 
            660                 665                 670         


Lys Ala Val Asn Gln Ala Ile Gln Arg Ala Gly Arg Leu Arg Val Gly 
        675                 680                 685             


Lys Pro Lys Asn Gln Val Ile Thr Ala Cys Arg Asp Ala Ile Arg Ser 
    690                 695                 700                 


Asn Asn Ile Asn Thr Leu Phe Lys Ile Met Arg Val Gly Thr Ala Ser 
705                 710                 715                 720 


Ser 
    


<210>  63
<211>  1560
<212>  DNA
<213>  Homo sapiens

<400>  63
atggctgagg agagagtcgc gacgagaact caatttcctg tatctactga gtctcaaaaa       60

ccccggcaga aaaaagctcc agagtttcct attttggaga agcagaactg gttgattcat      120

cttcattata tccggaaaga ttatgaagcc tgcaaggctg ttatcaaaga acagcttcaa      180

gagactcagg gattgtgtga atatgctatc tatgtccaag cattgatatt tcgcctagaa      240

ggaaatatcc aagaatccct agaactcttc cagacatgtg cagttcttag tcctcagagt      300

gctgataacc tcaagcaggt ggccagatct ttatttcttt tgggaaaaca taaagctgcc      360

attgaagtat ataatgaagc agctaaactc aaccagaaag attgggagat cagccataac      420

ctaggagttt gctacatata cctgaagcag ttcaacaagg cacaagacca gttgcacaat      480

gccctgaatc ttaataggca cgatctgact tatataatgc tggggaagat ccacttgctg      540

gagggagact tggacaaggc cattgaagtc tacaagaaag cagtggagtt ctcaccagaa      600

aatacagagc ttcttacaac tttaggatta ctctacttac agctcggcat ttaccagaag      660

gcatttgaac atcttggcaa tgcactgact tatgacccta ccaactacaa ggccatcttg      720

gcagcaggca gcatgatgca gacccacggg gactttgatg ttgccctcac caaatacaga      780

gttgtggctt gtgctgttcc agaaagtcct ccactctgga ataacattgg aatgtgtttc      840

tttggcaaga agaaatatgt ggcggccatc agctgcctga aacgagccaa ctacttggca      900

ccctttgatt ggaagattct gtataatttg ggccttgtcc atttgaccat gcagcagtat      960

gcatcagctt ttcattttct cagtgcggcc atcaacttcc agccaaagat gggggagctc     1020

tacatgctct tggcagtggc tctgaccaat ctggaagata tagaaaatgc caagagagcc     1080

tacgcagaag cagtccacct ggataagtgt aaccctttag taaacctgaa ctatgctgtg     1140

ctgctgtaca accagggcga gaagaagaac gccctggccc aatatcagga gatggagaag     1200

aaagtcagcc tactcaagga caatagctct ctggaatttg actctgagat ggtggagatg     1260

gctcagaagt tgggagctgc tctccaggtt ggggaggcac tggtctggac caaaccagtt     1320

aaagatccca aatcaaagca ccagaccact tcaaccagca aacctgccag tttccagcag     1380

cctctgggct ctaatcaagc tctaggacag gcaatgtctt cagcagctgc atacaggacg     1440

ctcccctcag gtgctggagg aacatcccag ttcacaaagc ccccatctct tcctctggag     1500

ccagagcctg cggtggaatc aagtccaact gaaacatcag aacaaataag agagaaataa     1560


<210>  64
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Ala Glu Glu Arg Val Ala Thr Arg Thr Gln Phe Pro Val Ser Thr 
1               5                   10                  15      


Glu Ser Gln Lys Pro Arg Gln Lys Lys Ala Pro Glu Phe Pro Ile Leu 
            20                  25                  30          


Glu Lys Gln Asn Trp Leu Ile His Leu His Tyr Ile Arg Lys Asp Tyr 
        35                  40                  45              


Glu Ala Cys Lys Ala Val Ile Lys Glu Gln Leu Gln Glu Thr Gln Gly 
    50                  55                  60                  


Leu Cys Glu Tyr Ala Ile Tyr Val Gln Ala Leu Ile Phe Arg Leu Glu 
65                  70                  75                  80  


Gly Asn Ile Gln Glu Ser Leu Glu Leu Phe Gln Thr Cys Ala Val Leu 
                85                  90                  95      


Ser Pro Gln Ser Ala Asp Asn Leu Lys Gln Val Ala Arg Ser Leu Phe 
            100                 105                 110         


Leu Leu Gly Lys His Lys Ala Ala Ile Glu Val Tyr Asn Glu Ala Ala 
        115                 120                 125             


Lys Leu Asn Gln Lys Asp Trp Glu Ile Ser His Asn Leu Gly Val Cys 
    130                 135                 140                 


Tyr Ile Tyr Leu Lys Gln Phe Asn Lys Ala Gln Asp Gln Leu His Asn 
145                 150                 155                 160 


Ala Leu Asn Leu Asn Arg His Asp Leu Thr Tyr Ile Met Leu Gly Lys 
                165                 170                 175     


Ile His Leu Leu Glu Gly Asp Leu Asp Lys Ala Ile Glu Val Tyr Lys 
            180                 185                 190         


Lys Ala Val Glu Phe Ser Pro Glu Asn Thr Glu Leu Leu Thr Thr Leu 
        195                 200                 205             


Gly Leu Leu Tyr Leu Gln Leu Gly Ile Tyr Gln Lys Ala Phe Glu His 
    210                 215                 220                 


Leu Gly Asn Ala Leu Thr Tyr Asp Pro Thr Asn Tyr Lys Ala Ile Leu 
225                 230                 235                 240 


Ala Ala Gly Ser Met Met Gln Thr His Gly Asp Phe Asp Val Ala Leu 
                245                 250                 255     


Thr Lys Tyr Arg Val Val Ala Cys Ala Val Pro Glu Ser Pro Pro Leu 
            260                 265                 270         


Trp Asn Asn Ile Gly Met Cys Phe Phe Gly Lys Lys Lys Tyr Val Ala 
        275                 280                 285             


Ala Ile Ser Cys Leu Lys Arg Ala Asn Tyr Leu Ala Pro Phe Asp Trp 
    290                 295                 300                 


Lys Ile Leu Tyr Asn Leu Gly Leu Val His Leu Thr Met Gln Gln Tyr 
305                 310                 315                 320 


Ala Ser Ala Phe His Phe Leu Ser Ala Ala Ile Asn Phe Gln Pro Lys 
                325                 330                 335     


Met Gly Glu Leu Tyr Met Leu Leu Ala Val Ala Leu Thr Asn Leu Glu 
            340                 345                 350         


Asp Ile Glu Asn Ala Lys Arg Ala Tyr Ala Glu Ala Val His Leu Asp 
        355                 360                 365             


Lys Cys Asn Pro Leu Val Asn Leu Asn Tyr Ala Val Leu Leu Tyr Asn 
    370                 375                 380                 


Gln Gly Glu Lys Lys Asn Ala Leu Ala Gln Tyr Gln Glu Met Glu Lys 
385                 390                 395                 400 


Lys Val Ser Leu Leu Lys Asp Asn Ser Ser Leu Glu Phe Asp Ser Glu 
                405                 410                 415     


Met Val Glu Met Ala Gln Lys Leu Gly Ala Ala Leu Gln Val Gly Glu 
            420                 425                 430         


Ala Leu Val Trp Thr Lys Pro Val Lys Asp Pro Lys Ser Lys His Gln 
        435                 440                 445             


Thr Thr Ser Thr Ser Lys Pro Ala Ser Phe Gln Gln Pro Leu Gly Ser 
    450                 455                 460                 


Asn Gln Ala Leu Gly Gln Ala Met Ser Ser Ala Ala Ala Tyr Arg Thr 
465                 470                 475                 480 


Leu Pro Ser Gly Ala Gly Gly Thr Ser Gln Phe Thr Lys Pro Pro Ser 
                485                 490                 495     


Leu Pro Leu Glu Pro Glu Pro Ala Val Glu Ser Ser Pro Thr Glu Thr 
            500                 505                 510         


Ser Glu Gln Ile Arg Glu Lys 
        515                 


<210>  65
<211>  6648
<212>  DNA
<213>  Homo sapiens

<400>  65
atggtgattc ttcagcaggg ggaccatgtg tggatggacc tgagattggg gcaggagttc       60

gacgtgccca tcggggcggt ggtgaagctc tgcgactctg ggcaggtcca ggtggtggat      120

gatgaagaca atgaacactg gatctctccg cagaacgcaa cgcacatcaa gcctatgcac      180

cccacgtcgg tccacggcgt ggaggacatg atccgcctgg gggacctcaa cgaggcgggc      240

atcttgcgca acctgcttat ccgctaccgg gaccacctca tctacacgta tacgggctcc      300

atcctggtgg ctgtgaaccc ctaccagctg ctctccatct actcgccaga gcacatccgc      360

cagtatacca acaagaagat tggggagatg cccccccaca tctttgccat tgctgacaac      420

tgctacttca acatgaaacg caacagccga gaccagtgct gcatcatcag tggggaatct      480

ggggccggga agacggagag cacaaagctg atcctgcagt tcctggcagc catcagtggg      540

cagcactcgt ggattgagca gcaggtcttg gaggccaccc ccattctgga agcatttggg      600

aatgccaaga ccatccgcaa tgacaactca agccgtttcg gaaagtacat cgacatccac      660

ttcaacaagc ggggcgccat cgagggcgcg aagattgagc agtacctgct ggaaaagtca      720

cgtgtctgtc gccaggccct ggatgaaagg aactaccacg tgttctactg catgctggag      780

ggtatgagtg aggatcagaa gaagaagctg ggcttgggcc aggcctctga ctacaactac      840

ttggccatgg gtaactgcat aacctgtgag ggccgggtgg acagccagga gtacgccaac      900

atccgctccg ccatgaaggt gctcatgttc actgacaccg agaactggga gatctcgaag      960

ctcctggctg ccatcctgca cctgggcaac ctgcagtatg aggcacgcac atttgaaaac     1020

ctggatgcct gtgaggttct cttctcccca tcgctggcca cagctgcatc cctgcttgag     1080

gtgaaccccc cagacctgat gagctgcctg actagccgca ccctcatcac ccgcggggag     1140

acggtgtcca ccccactgag cagggaacag gcactggacg tgcgcgacgc cttcgtaaag     1200

gggatctacg ggcggctgtt cgtgtggatt gtggacaaga tcaacgcagc aatttacaag     1260

cctccctccc aggatgtgaa gaactctcgc aggtccatcg gcctcctgga catctttggg     1320

tttgagaact ttgctgtgaa cagctttgag cagctctgca tcaacttcgc caatgagcac     1380

ctgcagcagt tctttgtgcg gcacgtgttc aagctggagc aggaggaata tgacctggag     1440

agcattgact ggctgcacat cgagttcact gacaaccagg atgccctgga catgattgcc     1500

aacaagccca tgaacatcat ctccctcatc gatgaggaga gcaagttccc caagggcaca     1560

gacaccacca tgttacacaa gctgaactcc cagcacaagc tcaacgccaa ctacatcccc     1620

cccaagaaca accatgagac ccagtttggc atcaaccatt ttgcaggcat cgtctactat     1680

gagacccaag gcttcctgga gaagaaccga gacaccctgc atggggacat tatccagctg     1740

gtccactcct ccaggaacaa gttcatcaag cagatcttcc aggccgatgt cgccatgggc     1800

gccgagacca ggaagcgctc gcccacactt agcagccagt tcaagcggtc actggagctg     1860

ctgatgcgca cgctgggtgc ctgccagccc ttctttgtgc gatgcatcaa gcccaatgag     1920

ttcaagaagc ccatgctgtt cgaccggcac ctgtgcgtgc gccagctgcg gtactcagga     1980

atgatggaga ccatccgaat ccgccgagct ggctacccca tccgctacag cttcgtagag     2040

tttgtggagc ggtaccgtgt gctgctgcca ggtgtgaagc cggcctacaa gcagggcgac     2100

ctccgcggga cttgccagcg catggctgag gctgtgctgg gcacccacga tgactggcag     2160

ataggcaaaa ccaagatctt tctgaaggac caccatgaca tgctgctgga agtggagcgg     2220

gacaaagcca tcaccgacag agtcatcctc cttcagaaag tcatccgggg attcaaagac     2280

aggtctaact ttctgaagct gaagaacgct gccacactga tccagaggca ctggcggggt     2340

cacaactgta ggaagaacta cgggctgatg cgtctgggct tcctgcggct gcaggccctg     2400

caccgctccc ggaagctgca ccagcagtac cgcctggccc gccagcgcat catccagttc     2460

caggcccgct gccgcgccta tctggtgcgc aaggccttcc gccaccgcct ctgggctgtg     2520

ctcaccgtgc aggcctatgc ccggggcatg atcgcccgca ggctgcacca acgcctcagg     2580

gctgagtatc tgtggcgcct cgaggctgag aaaatgcggc tggcggagga agagaagctt     2640

cggaaggaga tgagcgccaa gaaggccaag gaggaggccg agcgcaagca tcaggagcgc     2700

ctggcccagc tggctcgtga ggacgctgag cgggagctga aggagaagga ggccgctcgg     2760

cggaagaagg agctcctgga gcagatggaa agggcccgcc atgagcctgt caatcactca     2820

gacatggtgg acaagatgtt tggcttcctg gggacttcag gtggcctgcc aggccaggag     2880

ggccaggcac ctagtggctt tgaggacctg gagcgagggc ggagggagat ggtggaggag     2940

gacctggatg cagccctgcc cctgcctgac gaggatgagg aggacctctc tgagtataaa     3000

tttgccaagt tcgcggccac ctacttccag gggacaacca cgcactccta cacccggcgg     3060

ccactcaaac agccactgct ctaccatgac gacgagggtg accagctggc agccctggcg     3120

gtctggatca ccatcctccg cttcatgggg gacctccctg agcccaagta ccacacagcc     3180

atgagtgatg gcagtgagaa gatccctgtg atgaccaaga tttatgagac cctgggcaag     3240

aagacgtaca agagggagct gcaggccctg cagggcgagg gcgaggccca gctccccgag     3300

ggccagaaga agagcagtgt gaggcacaag ctggtgcatt tgactctgaa aaagaagtcc     3360

aagctcacag aggaggtgac caagaggctg catgacgggg agtccacagt gcagggcaac     3420

agcatgctgg aggaccggcc cacctccaac ctggagaagc tgcacttcat catcggcaat     3480

ggcatcctgc ggccagcact ccgggacgag atctactgcc agatcagcaa gcagctgacc     3540

cacaacccct ccaagagcag ctatgcccgg ggctggattc tcgtgtctct ctgcgtgggc     3600

tgtttcgccc cctccgagaa gtttgtcaag tacctgcgga acttcatcca cgggggcccg     3660

cccggctacg ccccgtactg tgaggagcgc ctgagaagga cctttgtcaa tgggacacgg     3720

acacagccgc ccagctggct ggagctgcag gccaccaagt ccaagaagcc aatcatgttg     3780

cccgtgacat tcatggatgg gaccaccaag accctgctga cggactcggc aaccacggcc     3840

aaggagctct gcaacgcgct ggccgacaag atctctctca aggaccggtt cgggttctcc     3900

ctctacattg ccctgtttga caaggtgtcc tccctgggca gcggcagtga ccacgtcatg     3960

gacgccatct cccagtgcga gcagtacgcc aaggagcagg gcgcccagga gcgcaacgcc     4020

ccctggaggc tcttcttccg caaagaggtc ttcacgccct ggcacagccc ctccgaggac     4080

aacgtggcca ccaacctcat ctaccagcag gtggtgcgag gagtcaagtt tggggagtac     4140

aggtgtgaga aggaggacga cctggctgag ctggcctccc agcagtactt tgtagactat     4200

ggctctgaga tgatcctgga gcgcctcctg aacctcgtgc ccacctacat ccccgaccgc     4260

gagatcacgc ccctgaagac gctggagaag tgggcccagc tggccatcgc cgcccacaag     4320

aaggggattt atgcccagag gagaactgat gcccagaagg tcaaagagga tgtggtcagt     4380

tatgcccgct tcaagtggcc cttgctcttc tccaggtttt atgaagccta caaattctca     4440

ggccccagtc tccccaagaa cgacgtcatc gtggccgtca actggacggg tgtgtacttt     4500

gtggatgagc aggagcaggt acttctggag ctgtccttcc cagagatcat ggccgtgtcc     4560

agcagcaggg agtgccgtgt ctggctctca ctgggctgct ctgatcttgg ctgtgctgcg     4620

cctcactcag gctgggcagg actgaccccg gcggggccct gttctccgtg ttggtcctgc     4680

aggggagcga aaacgacggc ccccagcttc acgctggcca ccatcaaggg ggacgaatac     4740

accttcacct ccagcaatgc tgaggacatt cgtgacctgg tggtcacctt cctagagggg     4800

ctccggaaga gatctaagta tgttgtggcc ctgcaggata accccaaccc cgcaggcgag     4860

gagtcaggct tcctcagctt tgccaaggga gacctcatca tcctggacca tgacacgggc     4920

gagcaggtca tgaactcggg ctgggccaac ggcatcaatg agaggaccaa gcagcgtggg     4980

gacttcccca ccgacagtgt gtacgtcatg cccactgtca ccatgccacc gcgggagatt     5040

gtggccctgg tcaccatgac tcccgatcag aggcaggacg ttgtccggct cttgcagctg     5100

cgaacggcgg agcccgaggt gcgtgccaag ccctacacgc tggaggagtt ttcctatgac     5160

tacttcaggc ccccacccaa gcacacgctg agccgtgtca tggtgtccaa ggcccgaggc     5220

aaggaccggc tgtggagcca cacgcgggaa ccgctcaagc aggcgctgct caagaagctc     5280

ctgggcagtg aggagctctc gcaggaggcc tgcctggcct tcattgctgt gctcaagtac     5340

atgggcgact acccgtccaa gaggacacgc tccgtcaacg agctcaccga ccagatcttt     5400

gagggtcccc tgaaagccga gcccctgaag gacgaggcat atgtgcagat cctgaagcag     5460

ctgaccgaca accacatcag gtacagcgag gagcggggtt gggagctgct ctggctgtgc     5520

acgggccttt tcccacccag caacatcctc ctgccccacg tgcagcgctt cctgcagtcc     5580

cgaaagcact gcccactcgc catcgactgc ctgcaacggc tccagaaagc cctgagaaac     5640

gggtcccgga agtaccctcc gcacctggtg gaggtggagg ccatccagca caagaccacc     5700

cagattttcc acaaagtcta cttccctgat gacactgacg aggccttcga agtggagtcc     5760

agcaccaagg ccaaggactt ctgccagaac atcgccacca ggctgctcct caagtcctca     5820

gagggattca gcctctttgt caaaattgca gacaaggtcc tcagcgttcc tgagaatgac     5880

ttcttctttg actttgttcg acacttgaca gactggataa agaaagctcg gcccatcaag     5940

gacggaattg tgccctcact cacctaccag gtgttcttca tgaagaagct gtggaccacc     6000

acggtgccag ggaaggatcc catggccgat tccatcttcc actattacca ggagttgccc     6060

aagtatctcc gaggctacca caagtgcacg cgggaggagg tgctgcagct gggggcgctg     6120

atctacaggg tcaagttcga ggaggacaag tcctacttcc ccagcatccc caagctgctg     6180

cgggagctgg tgccccagga ccttatccgg caggtctcac ctgatgactg gaagcggtcc     6240

atcgtcgcct acttcaacaa gcacgcaggg aagtccaagg aggaggccaa gctggccttc     6300

ctgaagctca tcttcaagtg gcccaccttt ggctcagcct tcttcgaggt gaagcaaact     6360

acggagccaa acttccctga gatcctccta attgccatca acaagtatgg ggtcagcctc     6420

atcgatccca aaacgaagga tatcctcacc actcatccct tcaccaagat ctccaactgg     6480

agcagcggca acacctactt ccacatcacc attgggaact tggtgcgcgg gagcaaactg     6540

ctctgcgaga cgtcactggg ctacaagatg gatgacctcc tgacttccta cattagccag     6600

atgctcacag ccatgagcaa acagcggggc tccaggagcg gcaagtga                  6648


<210>  66
<211>  2215
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Val Ile Leu Gln Gln Gly Asp His Val Trp Met Asp Leu Arg Leu 
1               5                   10                  15      


Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp 
            20                  25                  30          


Ser Gly Gln Val Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile 
        35                  40                  45              


Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val 
    50                  55                  60                  


His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser 
            100                 105                 110         


Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly 
        115                 120                 125             


Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn 
    130                 135                 140                 


Met Lys Arg Asn Ser Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg 
    210                 215                 220                 


Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Leu Asp Glu Arg Asn Tyr His Val Phe Tyr 
                245                 250                 255     


Cys Met Leu Glu Gly Met Ser Glu Asp Gln Lys Lys Lys Leu Gly Leu 
            260                 265                 270         


Gly Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr 
        275                 280                 285             


Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Leu Gly Asn Leu Gln Tyr Glu Ala Arg 
                325                 330                 335     


Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu 
            340                 345                 350         


Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser 
        355                 360                 365             


Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr 
    370                 375                 380                 


Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Asp Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys Asn Ser Arg Arg Ser 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Ala Val Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu 
465                 470                 475                 480 


Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Asp Ala Leu 
                485                 490                 495     


Asp Met Ile Ala Asn Lys Pro Met Asn Ile Ile Ser Leu Ile Asp Glu 
            500                 505                 510         


Glu Ser Lys Phe Pro Lys Gly Thr Asp Thr Thr Met Leu His Lys Leu 
        515                 520                 525             


Asn Ser Gln His Lys Leu Asn Ala Asn Tyr Ile Pro Pro Lys Asn Asn 
    530                 535                 540                 


His Glu Thr Gln Phe Gly Ile Asn His Phe Ala Gly Ile Val Tyr Tyr 
545                 550                 555                 560 


Glu Thr Gln Gly Phe Leu Glu Lys Asn Arg Asp Thr Leu His Gly Asp 
                565                 570                 575     


Ile Ile Gln Leu Val His Ser Ser Arg Asn Lys Phe Ile Lys Gln Ile 
            580                 585                 590         


Phe Gln Ala Asp Val Ala Met Gly Ala Glu Thr Arg Lys Arg Ser Pro 
        595                 600                 605             


Thr Leu Ser Ser Gln Phe Lys Arg Ser Leu Glu Leu Leu Met Arg Thr 
    610                 615                 620                 


Leu Gly Ala Cys Gln Pro Phe Phe Val Arg Cys Ile Lys Pro Asn Glu 
625                 630                 635                 640 


Phe Lys Lys Pro Met Leu Phe Asp Arg His Leu Cys Val Arg Gln Leu 
                645                 650                 655     


Arg Tyr Ser Gly Met Met Glu Thr Ile Arg Ile Arg Arg Ala Gly Tyr 
            660                 665                 670         


Pro Ile Arg Tyr Ser Phe Val Glu Phe Val Glu Arg Tyr Arg Val Leu 
        675                 680                 685             


Leu Pro Gly Val Lys Pro Ala Tyr Lys Gln Gly Asp Leu Arg Gly Thr 
    690                 695                 700                 


Cys Gln Arg Met Ala Glu Ala Val Leu Gly Thr His Asp Asp Trp Gln 
705                 710                 715                 720 


Ile Gly Lys Thr Lys Ile Phe Leu Lys Asp His His Asp Met Leu Leu 
                725                 730                 735     


Glu Val Glu Arg Asp Lys Ala Ile Thr Asp Arg Val Ile Leu Leu Gln 
            740                 745                 750         


Lys Val Ile Arg Gly Phe Lys Asp Arg Ser Asn Phe Leu Lys Leu Lys 
        755                 760                 765             


Asn Ala Ala Thr Leu Ile Gln Arg His Trp Arg Gly His Asn Cys Arg 
    770                 775                 780                 


Lys Asn Tyr Gly Leu Met Arg Leu Gly Phe Leu Arg Leu Gln Ala Leu 
785                 790                 795                 800 


His Arg Ser Arg Lys Leu His Gln Gln Tyr Arg Leu Ala Arg Gln Arg 
                805                 810                 815     


Ile Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr Leu Val Arg Lys Ala 
            820                 825                 830         


Phe Arg His Arg Leu Trp Ala Val Leu Thr Val Gln Ala Tyr Ala Arg 
        835                 840                 845             


Gly Met Ile Ala Arg Arg Leu His Gln Arg Leu Arg Ala Glu Tyr Leu 
    850                 855                 860                 


Trp Arg Leu Glu Ala Glu Lys Met Arg Leu Ala Glu Glu Glu Lys Leu 
865                 870                 875                 880 


Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu Glu Ala Glu Arg Lys 
                885                 890                 895     


His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu Asp Ala Glu Arg Glu 
            900                 905                 910         


Leu Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys Glu Leu Leu Glu Gln 
        915                 920                 925             


Met Glu Arg Ala Arg His Glu Pro Val Asn His Ser Asp Met Val Asp 
    930                 935                 940                 


Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly Leu Pro Gly Gln Glu 
945                 950                 955                 960 


Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu Arg Gly Arg Arg Glu 
                965                 970                 975     


Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro Leu Pro Asp Glu Asp 
            980                 985                 990         


Glu Glu Asp Leu Ser Glu Tyr Lys  Phe Ala Lys Phe Ala  Ala Thr Tyr 
        995                 1000                 1005             


Phe Gln  Gly Thr Thr Thr His  Ser Tyr Thr Arg Arg  Pro Leu Lys 
    1010                 1015                 1020             


Gln Pro  Leu Leu Tyr His Asp  Asp Glu Gly Asp Gln  Leu Ala Ala 
    1025                 1030                 1035             


Leu Ala  Val Trp Ile Thr Ile  Leu Arg Phe Met Gly  Asp Leu Pro 
    1040                 1045                 1050             


Glu Pro  Lys Tyr His Thr Ala  Met Ser Asp Gly Ser  Glu Lys Ile 
    1055                 1060                 1065             


Pro Val  Met Thr Lys Ile Tyr  Glu Thr Leu Gly Lys  Lys Thr Tyr 
    1070                 1075                 1080             


Lys Arg  Glu Leu Gln Ala Leu  Gln Gly Glu Gly Glu  Ala Gln Leu 
    1085                 1090                 1095             


Pro Glu  Gly Gln Lys Lys Ser  Ser Val Arg His Lys  Leu Val His 
    1100                 1105                 1110             


Leu Thr  Leu Lys Lys Lys Ser  Lys Leu Thr Glu Glu  Val Thr Lys 
    1115                 1120                 1125             


Arg Leu  His Asp Gly Glu Ser  Thr Val Gln Gly Asn  Ser Met Leu 
    1130                 1135                 1140             


Glu Asp  Arg Pro Thr Ser Asn  Leu Glu Lys Leu His  Phe Ile Ile 
    1145                 1150                 1155             


Gly Asn  Gly Ile Leu Arg Pro  Ala Leu Arg Asp Glu  Ile Tyr Cys 
    1160                 1165                 1170             


Gln Ile  Ser Lys Gln Leu Thr  His Asn Pro Ser Lys  Ser Ser Tyr 
    1175                 1180                 1185             


Ala Arg  Gly Trp Ile Leu Val  Ser Leu Cys Val Gly  Cys Phe Ala 
    1190                 1195                 1200             


Pro Ser  Glu Lys Phe Val Lys  Tyr Leu Arg Asn Phe  Ile His Gly 
    1205                 1210                 1215             


Gly Pro  Pro Gly Tyr Ala Pro  Tyr Cys Glu Glu Arg  Leu Arg Arg 
    1220                 1225                 1230             


Thr Phe  Val Asn Gly Thr Arg  Thr Gln Pro Pro Ser  Trp Leu Glu 
    1235                 1240                 1245             


Leu Gln  Ala Thr Lys Ser Lys  Lys Pro Ile Met Leu  Pro Val Thr 
    1250                 1255                 1260             


Phe Met  Asp Gly Thr Thr Lys  Thr Leu Leu Thr Asp  Ser Ala Thr 
    1265                 1270                 1275             


Thr Ala  Lys Glu Leu Cys Asn  Ala Leu Ala Asp Lys  Ile Ser Leu 
    1280                 1285                 1290             


Lys Asp  Arg Phe Gly Phe Ser  Leu Tyr Ile Ala Leu  Phe Asp Lys 
    1295                 1300                 1305             


Val Ser  Ser Leu Gly Ser Gly  Ser Asp His Val Met  Asp Ala Ile 
    1310                 1315                 1320             


Ser Gln  Cys Glu Gln Tyr Ala  Lys Glu Gln Gly Ala  Gln Glu Arg 
    1325                 1330                 1335             


Asn Ala  Pro Trp Arg Leu Phe  Phe Arg Lys Glu Val  Phe Thr Pro 
    1340                 1345                 1350             


Trp His  Ser Pro Ser Glu Asp  Asn Val Ala Thr Asn  Leu Ile Tyr 
    1355                 1360                 1365             


Gln Gln  Val Val Arg Gly Val  Lys Phe Gly Glu Tyr  Arg Cys Glu 
    1370                 1375                 1380             


Lys Glu  Asp Asp Leu Ala Glu  Leu Ala Ser Gln Gln  Tyr Phe Val 
    1385                 1390                 1395             


Asp Tyr  Gly Ser Glu Met Ile  Leu Glu Arg Leu Leu  Asn Leu Val 
    1400                 1405                 1410             


Pro Thr  Tyr Ile Pro Asp Arg  Glu Ile Thr Pro Leu  Lys Thr Leu 
    1415                 1420                 1425             


Glu Lys  Trp Ala Gln Leu Ala  Ile Ala Ala His Lys  Lys Gly Ile 
    1430                 1435                 1440             


Tyr Ala  Gln Arg Arg Thr Asp  Ala Gln Lys Val Lys  Glu Asp Val 
    1445                 1450                 1455             


Val Ser  Tyr Ala Arg Phe Lys  Trp Pro Leu Leu Phe  Ser Arg Phe 
    1460                 1465                 1470             


Tyr Glu  Ala Tyr Lys Phe Ser  Gly Pro Ser Leu Pro  Lys Asn Asp 
    1475                 1480                 1485             


Val Ile  Val Ala Val Asn Trp  Thr Gly Val Tyr Phe  Val Asp Glu 
    1490                 1495                 1500             


Gln Glu  Gln Val Leu Leu Glu  Leu Ser Phe Pro Glu  Ile Met Ala 
    1505                 1510                 1515             


Val Ser  Ser Ser Arg Glu Cys  Arg Val Trp Leu Ser  Leu Gly Cys 
    1520                 1525                 1530             


Ser Asp  Leu Gly Cys Ala Ala  Pro His Ser Gly Trp  Ala Gly Leu 
    1535                 1540                 1545             


Thr Pro  Ala Gly Pro Cys Ser  Pro Cys Trp Ser Cys  Arg Gly Ala 
    1550                 1555                 1560             


Lys Thr  Thr Ala Pro Ser Phe  Thr Leu Ala Thr Ile  Lys Gly Asp 
    1565                 1570                 1575             


Glu Tyr  Thr Phe Thr Ser Ser  Asn Ala Glu Asp Ile  Arg Asp Leu 
    1580                 1585                 1590             


Val Val  Thr Phe Leu Glu Gly  Leu Arg Lys Arg Ser  Lys Tyr Val 
    1595                 1600                 1605             


Val Ala  Leu Gln Asp Asn Pro  Asn Pro Ala Gly Glu  Glu Ser Gly 
    1610                 1615                 1620             


Phe Leu  Ser Phe Ala Lys Gly  Asp Leu Ile Ile Leu  Asp His Asp 
    1625                 1630                 1635             


Thr Gly  Glu Gln Val Met Asn  Ser Gly Trp Ala Asn  Gly Ile Asn 
    1640                 1645                 1650             


Glu Arg  Thr Lys Gln Arg Gly  Asp Phe Pro Thr Asp  Ser Val Tyr 
    1655                 1660                 1665             


Val Met  Pro Thr Val Thr Met  Pro Pro Arg Glu Ile  Val Ala Leu 
    1670                 1675                 1680             


Val Thr  Met Thr Pro Asp Gln  Arg Gln Asp Val Val  Arg Leu Leu 
    1685                 1690                 1695             


Gln Leu  Arg Thr Ala Glu Pro  Glu Val Arg Ala Lys  Pro Tyr Thr 
    1700                 1705                 1710             


Leu Glu  Glu Phe Ser Tyr Asp  Tyr Phe Arg Pro Pro  Pro Lys His 
    1715                 1720                 1725             


Thr Leu  Ser Arg Val Met Val  Ser Lys Ala Arg Gly  Lys Asp Arg 
    1730                 1735                 1740             


Leu Trp  Ser His Thr Arg Glu  Pro Leu Lys Gln Ala  Leu Leu Lys 
    1745                 1750                 1755             


Lys Leu  Leu Gly Ser Glu Glu  Leu Ser Gln Glu Ala  Cys Leu Ala 
    1760                 1765                 1770             


Phe Ile  Ala Val Leu Lys Tyr  Met Gly Asp Tyr Pro  Ser Lys Arg 
    1775                 1780                 1785             


Thr Arg  Ser Val Asn Glu Leu  Thr Asp Gln Ile Phe  Glu Gly Pro 
    1790                 1795                 1800             


Leu Lys  Ala Glu Pro Leu Lys  Asp Glu Ala Tyr Val  Gln Ile Leu 
    1805                 1810                 1815             


Lys Gln  Leu Thr Asp Asn His  Ile Arg Tyr Ser Glu  Glu Arg Gly 
    1820                 1825                 1830             


Trp Glu  Leu Leu Trp Leu Cys  Thr Gly Leu Phe Pro  Pro Ser Asn 
    1835                 1840                 1845             


Ile Leu  Leu Pro His Val Gln  Arg Phe Leu Gln Ser  Arg Lys His 
    1850                 1855                 1860             


Cys Pro  Leu Ala Ile Asp Cys  Leu Gln Arg Leu Gln  Lys Ala Leu 
    1865                 1870                 1875             


Arg Asn  Gly Ser Arg Lys Tyr  Pro Pro His Leu Val  Glu Val Glu 
    1880                 1885                 1890             


Ala Ile  Gln His Lys Thr Thr  Gln Ile Phe His Lys  Val Tyr Phe 
    1895                 1900                 1905             


Pro Asp  Asp Thr Asp Glu Ala  Phe Glu Val Glu Ser  Ser Thr Lys 
    1910                 1915                 1920             


Ala Lys  Asp Phe Cys Gln Asn  Ile Ala Thr Arg Leu  Leu Leu Lys 
    1925                 1930                 1935             


Ser Ser  Glu Gly Phe Ser Leu  Phe Val Lys Ile Ala  Asp Lys Val 
    1940                 1945                 1950             


Leu Ser  Val Pro Glu Asn Asp  Phe Phe Phe Asp Phe  Val Arg His 
    1955                 1960                 1965             


Leu Thr  Asp Trp Ile Lys Lys  Ala Arg Pro Ile Lys  Asp Gly Ile 
    1970                 1975                 1980             


Val Pro  Ser Leu Thr Tyr Gln  Val Phe Phe Met Lys  Lys Leu Trp 
    1985                 1990                 1995             


Thr Thr  Thr Val Pro Gly Lys  Asp Pro Met Ala Asp  Ser Ile Phe 
    2000                 2005                 2010             


His Tyr  Tyr Gln Glu Leu Pro  Lys Tyr Leu Arg Gly  Tyr His Lys 
    2015                 2020                 2025             


Cys Thr  Arg Glu Glu Val Leu  Gln Leu Gly Ala Leu  Ile Tyr Arg 
    2030                 2035                 2040             


Val Lys  Phe Glu Glu Asp Lys  Ser Tyr Phe Pro Ser  Ile Pro Lys 
    2045                 2050                 2055             


Leu Leu  Arg Glu Leu Val Pro  Gln Asp Leu Ile Arg  Gln Val Ser 
    2060                 2065                 2070             


Pro Asp  Asp Trp Lys Arg Ser  Ile Val Ala Tyr Phe  Asn Lys His 
    2075                 2080                 2085             


Ala Gly  Lys Ser Lys Glu Glu  Ala Lys Leu Ala Phe  Leu Lys Leu 
    2090                 2095                 2100             


Ile Phe  Lys Trp Pro Thr Phe  Gly Ser Ala Phe Phe  Glu Val Lys 
    2105                 2110                 2115             


Gln Thr  Thr Glu Pro Asn Phe  Pro Glu Ile Leu Leu  Ile Ala Ile 
    2120                 2125                 2130             


Asn Lys  Tyr Gly Val Ser Leu  Ile Asp Pro Lys Thr  Lys Asp Ile 
    2135                 2140                 2145             


Leu Thr  Thr His Pro Phe Thr  Lys Ile Ser Asn Trp  Ser Ser Gly 
    2150                 2155                 2160             


Asn Thr  Tyr Phe His Ile Thr  Ile Gly Asn Leu Val  Arg Gly Ser 
    2165                 2170                 2175             


Lys Leu  Leu Cys Glu Thr Ser  Leu Gly Tyr Lys Met  Asp Asp Leu 
    2180                 2185                 2190             


Leu Thr  Ser Tyr Ile Ser Gln  Met Leu Thr Ala Met  Ser Lys Gln 
    2195                 2200                 2205             


Arg Gly  Ser Arg Ser Gly Lys  
    2210                 2215 


<210>  67
<211>  10065
<212>  DNA
<213>  Homo sapiens

<400>  67
atggggcgcc atgttgccac cagctgccac gtggcctggc ttttggtgct gatctctgga       60

tgctggggcc aggtgaaccg gctgcccttc ttcaccaacc acttctttga tacatacctg      120

ctgatcagcg aggacacgcc tgtgggttct tctgtgaccc agttgctggc ccaagacatg      180

gacaatgacc ccctggtgtt tggcgtgtct ggggaggagg cctctcgctt ctttgcagtg      240

gagcctgaca ctggcgtggt gtggctccgg cagccactgg acagagagac caagtcagag      300

ttcaccgtgg agttctctgt cagcgaccac cagggggtga tcacacggaa ggtgaacatc      360

caggttgggg atgtgaatga caacgcgccc acatttcaca atcagcccta cagcgtccgc      420

atccctgaga atacaccagt ggggacgccc atcttcatcg tgaatgccac agaccccgac      480

ttgggggcag ggggcagcgt cctctactcc ttccagcccc cctcccaatt cttcgccatt      540

gacagcgccc gcggtatcgt cacagtgatc cgggagctgg actacgagac cacacaggcc      600

taccagctca cggtcaacgc cacagatcaa gacaagacca ggcctctgtc caccctggcc      660

aacttggcca tcatcatcac agatgtccag gacatggacc ccatcttcat caacctgcct      720

tacagcacca acatctacga gcattctcct ccgggcacga cggtgcgcat catcaccgcc      780

atagaccagg ataaaggacg tccccggggc attggctaca ccatcgtttc agggaatacc      840

aacagcatct ttgccctgga ctacatcagc ggagtgctga ccttgaatgg cctgctggac      900

cgggagaacc ccctgtacag ccatggcttc atcctgactg tgaagggcac ggagctgaac      960

gatgaccgca ccccatctga cgctacagtc accacgacct tcaatatcct ggttattgac     1020

atcaatgaca atgccccgga gttcaacagc tccgagtaca gcgtggccat cactgagctg     1080

gcacaggtcg gctttgccct tccactcttc atccaggtgg tggacaagga tgagaatttg     1140

ggcctgaaca gcatgtttga ggtgtacttg gtggggaaca actcccacca cttcatcatc     1200

tccccgacct ccgtccaggg gaaggcggac attcgtattc gggtggccat cccactggac     1260

tacgagaccg tggaccgcta cgactttgat ctctttgcca atgagagtgt gcctgaccat     1320

gtgggctatg ccaaggtgaa gatcactctc atcaatgaaa atgacaaccg gcccatcttc     1380

agccagccac tgtacaacat cagcctgtac gagaacgtca ccgtggggac ctctgtgctg     1440

acagtcctgg caactgacaa tgatgcaggc acctttgggg aagtcagcta cttcttcagt     1500

gatgaccctg acaggttctc gctggacaag gacacgggac tcatcatgct gattgccagg     1560

ctggactatg agctcatcca gcgcttcacc ctgacgatca ttgcccggga cgggggcggc     1620

gaggagacca caggccgggt caggatcaat gtgttggatg tcaacgacaa cgtgcccacc     1680

ttccagaagg atgcctacgt gggtgctctg cgggagaacg agccttctgt cacacagctg     1740

gtgcggctcc gggcaacaga tgaagactcc cctcccaaca accagatcac ctacagcatt     1800

gtcagtgcat ctgcctttgg cagctacttc gacatcagcc tgtacgaggg ctatggagtg     1860

atcagcgtca gtcgccccct ggattatgaa cagatatcca atgggctgat ttatctgacg     1920

gtcatggcca tggatgctgg caacccccct ctcaacagca ccgtccctgt caccatcgag     1980

gtgtttgatg agaatgacaa ccctcccacc ttcagcaagc ccgcctactt cgtctccgtg     2040

gtggagaaca tcatggcagg agccacggtg ctgttcctga atgccacaga cctggaccgc     2100

tcccgggagt acggccagga gtccatcatc tactccttgg aaggctccac ccagtttcgg     2160

atcaatgccc gctcagggga aatcaccacc acgtctctgc ttgaccgaga gaccaagtct     2220

gaatacatcc tcatcgttcg cgcagtggac gggggtgtgg gccacaacca gaaaactggc     2280

atcgccaccg taaacatcac cctcctggac atcaatgaca accaccccac gtggaaggac     2340

gcaccctact acatcaacct ggtggagatg acccctccag actctgatgt gaccacggtg     2400

gtggctgttg acccagacct gggggagaat ggcaccctgg tgtacagcat ccagccaccc     2460

aacaagttct acagcctcaa cagcaccacg ggcaagatcc gcaccaccca cgccatgctg     2520

gaccgggaga accccgaccc ccatgaggcc gagctgatgc gcaaaatcgt cgtctctgtt     2580

actgactgtg gcaggccccc tctgaaagcc accagcagtg ccacagtgtt tgtgaacctc     2640

ttggatctca atgacaatga ccccaccttt cagaacctgc cttttgtggc cgaggtgctt     2700

gaaggcatcc cggcgggggt ctccatctac caagtggtgg ccatcgacct cgatgagggc     2760

ctgaacggcc tggtgtccta ccgcatgccg gtgggcatgc cccgcatgga cttcctcatc     2820

aacagcagca gcggcgtggt ggtcaccacc accgagctgg accgcgagcg catcgcggag     2880

taccagctgc gggtggtggc cagtgatgca ggcacgccca ccaagagctc caccagcacg     2940

ctcaccatcc atgtgctgga tgtgaacgac gagacgccca ccttcttccc ggccgtgtac     3000

aatgtgtctg tgtccgagga cgtgccacgc gagttccggg tggtctggct gaactgcacg     3060

gacaacgacg tgggcctcaa tgcagagctc agctacttca tcacaggtgg caacgtggat     3120

gggaagttca gcgtgggtta ccgcgatgcc gttgtgagaa ccgtggtggg cctggaccgg     3180

gagaccacag ccgcctacat gctcatcctg gaggccatcg acaacggccc tgtagggaag     3240

cgacacacgg gcacagccac cgtgttcgtc actgtcctgg atgtgaatga caaccggccc     3300

atctttctgc agagcagcta tgaggccagc gtccctgagg acatccctga aggccacagc     3360

atcttgcagc tgaaagccac ggacgcagat gagggcgagt ttgggcgtgt gtggtaccgc     3420

atcctccatg gtaaccatgg caacaacttc cggatccatg tcagcaatgg gctcctgatg     3480

cgagggcccc ggcccctgga ccgggagcgg aactcatccc acgtgctgat agtggaggcc     3540

tacaaccacg acctgggccc catgcggagc tccgtcaggg tgattgtgta cgtggaggac     3600

atcaacgatg aggcccccgt gttcacacag cagcagtaca gccgtctggg gcttcgagag     3660

accgcaggca ttggaacgtc agtcatcgtg gtccaagcca cagaccgaga ctctggggat     3720

ggtggcctgg tgaactaccg catcctgtcg ggcgcagagg ggaagtttga gattgacgag     3780

agcacagggc ttatcatcac cgtgaattac ctggactacg agaccaagac cagctacatg     3840

atgaatgtgt cggccactga ccaggccccg cccttcaacc agggcttctg cagcgtctac     3900

atcactctgc tcaacgagct ggacgaggcc gtgcagttct ccaatgcctc atacgaggct     3960

gccatcctgg agaatctggc actgggtact gagattgtgc gggtccaggc ctactccatc     4020

gacaacctca accaaatcac gtaccgcttc aacgcctaca ccagcaccca ggccaaagcc     4080

ctcttcaaga tagacgccat cacgggtgtg atcacagtcc agggcctggt ggaccgtgag     4140

aagggcgact tctatacctt gacagtggtg gcagatgacg gcggccccaa ggtggactcc     4200

accgtgaagg tctacatcac tgtgctggac gagaatgaca acagcccccg gtttgacttc     4260

acctccgact cggcggtcag catacccgag gactgccctg tgggccagcg agtggctact     4320

gtcaaggcct gggaccctga tgctggcagc aatgggcagg tggtcttctc cctggcctct     4380

ggcaacatcg cgggggcctt tgagatcgtc accaccaatg actccattgg cgaagtgttt     4440

gtggccaggc ccctggacag agaagagctg gatcactaca tcctccaggt tgtggcttct     4500

gaccgaggca cccctccacg gaagaaggac cacatcctgc aggtgaccat cctggacatc     4560

aatgacaacc ctccagtcat cgagagcccc tttggataca atgtcagtgt gaatgagaac     4620

gtgggtggag gtactgctgt ggtccaggtg agagccactg accgtgacat cgggatcaac     4680

agtgttctgt cctactacat caccgagggc aacaaggaca tggccttccg catggaccgc     4740

atcagcggtg agatcgccac acggcctgcc ccgcctgacc gcgagcgcca gagcttctac     4800

cacctggtgg ccactgtgga ggacgagggc accccaaccc tgtcggccac cacgcacgtg     4860

tacgtgacca ttgtggatga gaatgataac gcgcccatgt tccagcagcc ccactatgag     4920

gtgctgctgg atgagggccc agacacgctc aacaccagcc tcatcaccat ccaggcactg     4980

gacctggatg agggtcccaa cggcacagtc acctatgcca tcgtcgcagg caacatcgtc     5040

aacaccttcc gcatcgacag acacatgggt gtcatcactg ctgccaaaga gctggactac     5100

gagatcagcc acggccgcta caccctgatc gtcactgcca cagaccagtg ccccatctta     5160

tcccaccgcc tcacctctac caccacggtg cttgtgaatg tgaatgacat caacgacaat     5220

gtgcctacct tcccccggga ctatgaggga ccatttgaag tcactgaggg ccagccgggg     5280

cccagagtgt ggaccttcct ggcccatgac cgagactcag gacccaacgg gcaggtggag     5340

tacagcatca tggatggaga ccctctgggg gagtttgtga tctctcctgt ggagggggtg     5400

ctaagggtcc ggaaggacgt ggagctggac cgggagacca tcgccttcta caacctgacc     5460

atctgtgccc gtgaccgggg gatgccccca ctcagctcca caatgctggt ggggatccgg     5520

gtgctggaca tcaacgacaa cgaccctgtg ctgctgaacc tgcccatgaa catcaccatc     5580

agcgagaaca gccctgtctc cagctttgtc gcccatgtcc tggccagtga cgctgacagt     5640

ggctgcaatg cacgcctcac cttcaacatc actgcgggca accgcgagcg ggccttcttc     5700

atcaatgcca cgacagggat cgtcactgtg aaccggcccc tggaccgcga gcggatccca     5760

gagtacaagc tgaccatttc tgtgaaggac aacccggaga atccacgcat agccaggagg     5820

gattatgact tgcttctgat cttcctttct gatgagaatg acaaccaccc cctcttcact     5880

aaaagcacct accaggcaga ggtgatggaa aactctcccg ctggcacccc tctcacggtg     5940

ctcaatgggc ccatcctggc cctggatgca gaccaagaca tctacgccgt ggtgacctac     6000

cagctgctgg gtgcccagag tggcctcttt gacatcaaca gcagcaccgg tgtggtgacc     6060

gtgaggtcag gtgtcatcat tgaccgggag gcattctcgc cacccatcct ggagctgctg     6120

ctgctggctg aggacatcgg gctgctcaac agcacggccc acctgctcat caccatcctg     6180

gatgacaatg acaaccggcc cacctttagc cctgccaccc tcactgtcca tctgctagag     6240

aactgcccgc ctggattctc agtccttcaa gtcacagcca cagatgagga cagtggcctc     6300

aatggggagc tggtctaccg aatagaagct ggggctcagg accgcttcct cattcatctg     6360

gtcaccgggg tcatccgtgt tggtaatgcc accatcgaca gagaggagca ggagtcctac     6420

aggctaacgg tggtggccac cgaccggggc accgttcctc tctcgggcac agccattgtc     6480

accattctga tcgatgacat caatgactcc cgccccgagt tcctcaaccc catccagaca     6540

gtgagcgtgc tggagtcggc tgagccaggc actgtcattg ccaatatcac ggccattgac     6600

cacgacctca acccaaagct agagtaccac attgtcggca ttgtggccaa ggacgacact     6660

gatcgcctgg tgcccaacca ggaggacgcc tttgctgtga atatcaacac aggatctgta     6720

atggtgaagt cccccatgaa tcgggagctg gttgccacct atgaggtcac tctctcagtg     6780

attgacaatg ccagcgacct accagagcgc tctgtcagtg tgccaaatgc caagctgact     6840

gtcaacgtcc tggacgtcaa tgacaatacg ccccagttca agccctttgg gatcacctac     6900

tacatggagc ggatcctgga gggggccacc cctgggacca cactcattgc tgtggcagcc     6960

gtggaccctg acaagggcct taatgggctg gtcacctaca ccctgctgga cctggtgccc     7020

ccagggtatg tccagctgga ggactcctcg gcagggaagg tcattgccaa ccggacagtg     7080

gactacgagg aggtgcactg gctcaacttt accgtgaggg cctcagacaa cgggtccccg     7140

ccccgggcag ctgagatccc tgtctacctg gaaatcgtgg acatcaatga caacaacccc     7200

atctttgacc agccctccta ccaggaggct gtctttgagg atgtgcctgt gggcacaatc     7260

atcctgacag tcactgccac tgatgctgac tcaggcaact ttgcactcat tgagtacagc     7320

cttggagatg gagagagcaa gtttgccatc aaccccacca cgggtgacat ctatgtgctg     7380

tcttctctgg accgggagaa gaaggaccac tatatcctga ctgccttggc caaagacaac     7440

cctggggatg tagccagcaa ccgtcgcgaa aattcagtgc aggtggtgat ccaagtgctg     7500

gatgtcaatg actgccggcc acagttctcc aagccccagt tcagcacaag cgtgtatgag     7560

aatgagccgg cgggcacctc ggtcatcacc atgatggcca ctgaccagga tgaaggtccc     7620

aatggagagt tgacctactc acttgagggc cctggcgtgg aggccttcca tgtggacatg     7680

gactcgggct tggtgaccac acagcggcca ctgcagtcct acgagaagtt cagtctgacc     7740

gtggtggcca cagatggtgg agagccccca ctctggggca ccaccatgct cctggtggag     7800

gtcatcgacg tcaatgacaa ccgccctgtc tttgtgcgcc cacccaacgg caccatcctc     7860

cacatcagag aggagatccc gctgcgctcc aacgtgtacg aggtctacgc cacggacaag     7920

gatgagggcc tcaacggggc ggtgcgctac agcttcctga agactgcggg caaccgggac     7980

tgggagttct tcatcatcga cccaatcagc ggcctcatcc agactgctca gcgcctggac     8040

cgcgagtcgc aggcggtgta cagcctcatc ttggtggcca gcgacctggg ccagccagtg     8100

ccatacgaga ctatgcagcc gctgcaggtg gccctggagg acatcgatga caacgaaccc     8160

cttttcgtga ggcctccaaa aggcagcccc cagtaccagc tgctgacagt gcctgagcac     8220

tcaccacgcg gcaccctcgt gggcaacgtg acaggcgcag tggatgcaga tgagggcccc     8280

aacgcgatcg tgtactactt catcgcagcc ggcaacgaag agaagaactt ccatctgcag     8340

cccgatgggt gtctgctggt gctgcgggac ctggaccggg agcgagaagc catcttctcc     8400

ttcatcgtca aggcctccag caatcgcagc tggacacctc cccgtggacc ctccccaacc     8460

ctcgacctgg ttgctgacct cacactgcag gaggtgcgcg ttgtgctaga ggacatcaac     8520

gaccagccac cacgcttcac caaggctgag tacactgcag gggtggccac cgacgccaag     8580

gtgggctcag agttgatcca ggtgctggcc ctggatgcag acattggcaa caacagcctt     8640

gtcttctaca gcattctggc catccactac ttccgggccc ttgccaacga ctctgaagat     8700

gtgggccagg tcttcaccat ggggagcatg gacggcattc tgcgcacctt cgacctcttc     8760

atggcctaca gccccggcta cttcgtggtg gacattgtgg cccgagacct ggcaggccac     8820

aacgacacgg ccatcatcgg catctacatc ctgagggacg accagcgcgt caagatcgtc     8880

attaacgaga tccccgaccg tgtgcgcggc ttcgaggagg agttcatcca cctgctctcc     8940

aacatcactg gggccattgt caatactgac aatgtgcagt tccatgtgga caagaagggc     9000

cgggtgaact ttgcgcagac agaactgctt atccacgtgg tgaaccgcga taccaaccgc     9060

atcctggacg tggaccgggt gatccagatg atcgatgaga acaaggagca gctacggaat     9120

cttttccgga actacaacgt cctggacgtg cagcctgcca tctctgtccg gctgccggat     9180

gacatgtctg ccctgcagat ggcgatcatc gtcctggcta tcctcctgtt cctggccgcc     9240

atgctctttg tcctcatgaa ctggtactac aggactgtac acaagaggaa gctcaaggcc     9300

attgtggctg gctcagctgg gaatcgtggc ttcatcgaca tcatggacat gcctaacacc     9360

aacaagtact cctttgatgg agccaaccct gtgtggctgg atcccttctg tcggaacctg     9420

gagctggccg cccaggcgga gcatgaggat gacctaccgg agaacctgag tgagatcgcc     9480

gacctgtgga acagccccac gcgcacccat ggaacttttg ggcgtgagcc agcagctgtc     9540

aagcctgatg atgaccgata cctgcgggct gccatccagg agtatgacaa cattgccaag     9600

ctgggccaga tcattcgtga ggggccaatc aagggctcgc tgctgaaggt ggtcctggag     9660

gattacctgc ggctcaaaaa gctctttgca cagcggatgg tgcaaaaagc ctcctcctgc     9720

cactcctcca tctctgagct gatacagact gagctggacg aggagccagg agaccacagc     9780

ccagggcagg gtagcctgcg cttccgccac aagccaccag tggagctcaa ggggcccgat     9840

gggatccatg tggtgcacgg cagcacgggc acgctgctgg ccaccgacct caacagcctg     9900

cccgaggaag accagaaggg cctgggccgc tcgctggaga cgctgaccgc tgccgaggcc     9960

actgccttcg agcgcaacgc ccgcacagaa tccgccaaat ccacacccct gcacaaactt    10020

cgcgacgtga tcatggagac ccccctggag atcacagagc tgtga                    10065


<210>  68
<211>  3354
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val 
1               5                   10                  15      


Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr 
            20                  25                  30          


Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val 
        35                  40                  45              


Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro 
    50                  55                  60                  


Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val 
65                  70                  75                  80  


Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu 
                85                  90                  95      


Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly 
            100                 105                 110         


Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn 
        115                 120                 125             


Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn 
    130                 135                 140                 


Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln 
                165                 170                 175     


Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu 
            180                 185                 190         


Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr 
        195                 200                 205             


Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile 
    210                 215                 220                 


Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro 
225                 230                 235                 240 


Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg 
                245                 250                 255     


Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly 
            260                 265                 270         


Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr 
        275                 280                 285             


Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro 
    290                 295                 300                 


Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn 
305                 310                 315                 320 


Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile 
                325                 330                 335     


Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu 
            340                 345                 350         


Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro 
        355                 360                 365             


Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser 
    370                 375                 380                 


Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile 
385                 390                 395                 400 


Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala 
                405                 410                 415     


Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe 
            420                 425                 430         


Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile 
        435                 440                 445             


Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu 
    450                 455                 460                 


Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu 
465                 470                 475                 480 


Thr Val Leu Ala Thr Asp Asn Asp Ala Gly Thr Phe Gly Glu Val Ser 
                485                 490                 495     


Tyr Phe Phe Ser Asp Asp Pro Asp Arg Phe Ser Leu Asp Lys Asp Thr 
            500                 505                 510         


Gly Leu Ile Met Leu Ile Ala Arg Leu Asp Tyr Glu Leu Ile Gln Arg 
        515                 520                 525             


Phe Thr Leu Thr Ile Ile Ala Arg Asp Gly Gly Gly Glu Glu Thr Thr 
    530                 535                 540                 


Gly Arg Val Arg Ile Asn Val Leu Asp Val Asn Asp Asn Val Pro Thr 
545                 550                 555                 560 


Phe Gln Lys Asp Ala Tyr Val Gly Ala Leu Arg Glu Asn Glu Pro Ser 
                565                 570                 575     


Val Thr Gln Leu Val Arg Leu Arg Ala Thr Asp Glu Asp Ser Pro Pro 
            580                 585                 590         


Asn Asn Gln Ile Thr Tyr Ser Ile Val Ser Ala Ser Ala Phe Gly Ser 
        595                 600                 605             


Tyr Phe Asp Ile Ser Leu Tyr Glu Gly Tyr Gly Val Ile Ser Val Ser 
    610                 615                 620                 


Arg Pro Leu Asp Tyr Glu Gln Ile Ser Asn Gly Leu Ile Tyr Leu Thr 
625                 630                 635                 640 


Val Met Ala Met Asp Ala Gly Asn Pro Pro Leu Asn Ser Thr Val Pro 
                645                 650                 655     


Val Thr Ile Glu Val Phe Asp Glu Asn Asp Asn Pro Pro Thr Phe Ser 
            660                 665                 670         


Lys Pro Ala Tyr Phe Val Ser Val Val Glu Asn Ile Met Ala Gly Ala 
        675                 680                 685             


Thr Val Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu Tyr 
    690                 695                 700                 


Gly Gln Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr Gln Phe Arg 
705                 710                 715                 720 


Ile Asn Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu Leu Asp Arg 
                725                 730                 735     


Glu Thr Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val Asp Gly Gly 
            740                 745                 750         


Val Gly His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn Ile Thr Leu 
        755                 760                 765             


Leu Asp Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala Pro Tyr Tyr 
    770                 775                 780                 


Ile Asn Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val Thr Thr Val 
785                 790                 795                 800 


Val Ala Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu Val Tyr Ser 
                805                 810                 815     


Ile Gln Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr Thr Gly Lys 
            820                 825                 830         


Ile Arg Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro Asp Pro His 
        835                 840                 845             


Glu Ala Glu Leu Met Arg Lys Ile Val Val Ser Val Thr Asp Cys Gly 
    850                 855                 860                 


Arg Pro Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe Val Asn Leu 
865                 870                 875                 880 


Leu Asp Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu Pro Phe Val 
                885                 890                 895     


Ala Glu Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile Tyr Gln Val 
            900                 905                 910         


Val Ala Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val Ser Tyr Arg 
        915                 920                 925             


Met Pro Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn Ser Ser Ser 
    930                 935                 940                 


Gly Val Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg Ile Ala Glu 
945                 950                 955                 960 


Tyr Gln Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro Thr Lys Ser 
                965                 970                 975     


Ser Thr Ser Thr Leu Thr Ile His Val Leu Asp Val Asn Asp Glu Thr 
            980                 985                 990         


Pro Thr Phe Phe Pro Ala Val Tyr  Asn Val Ser Val Ser  Glu Asp Val 
        995                 1000                 1005             


Pro Arg  Glu Phe Arg Val Val  Trp Leu Asn Cys Thr  Asp Asn Asp 
    1010                 1015                 1020             


Val Gly  Leu Asn Ala Glu Leu  Ser Tyr Phe Ile Thr  Gly Gly Asn 
    1025                 1030                 1035             


Val Asp  Gly Lys Phe Ser Val  Gly Tyr Arg Asp Ala  Val Val Arg 
    1040                 1045                 1050             


Thr Val  Val Gly Leu Asp Arg  Glu Thr Thr Ala Ala  Tyr Met Leu 
    1055                 1060                 1065             


Ile Leu  Glu Ala Ile Asp Asn  Gly Pro Val Gly Lys  Arg His Thr 
    1070                 1075                 1080             


Gly Thr  Ala Thr Val Phe Val  Thr Val Leu Asp Val  Asn Asp Asn 
    1085                 1090                 1095             


Arg Pro  Ile Phe Leu Gln Ser  Ser Tyr Glu Ala Ser  Val Pro Glu 
    1100                 1105                 1110             


Asp Ile  Pro Glu Gly His Ser  Ile Leu Gln Leu Lys  Ala Thr Asp 
    1115                 1120                 1125             


Ala Asp  Glu Gly Glu Phe Gly  Arg Val Trp Tyr Arg  Ile Leu His 
    1130                 1135                 1140             


Gly Asn  His Gly Asn Asn Phe  Arg Ile His Val Ser  Asn Gly Leu 
    1145                 1150                 1155             


Leu Met  Arg Gly Pro Arg Pro  Leu Asp Arg Glu Arg  Asn Ser Ser 
    1160                 1165                 1170             


His Val  Leu Ile Val Glu Ala  Tyr Asn His Asp Leu  Gly Pro Met 
    1175                 1180                 1185             


Arg Ser  Ser Val Arg Val Ile  Val Tyr Val Glu Asp  Ile Asn Asp 
    1190                 1195                 1200             


Glu Ala  Pro Val Phe Thr Gln  Gln Gln Tyr Ser Arg  Leu Gly Leu 
    1205                 1210                 1215             


Arg Glu  Thr Ala Gly Ile Gly  Thr Ser Val Ile Val  Val Gln Ala 
    1220                 1225                 1230             


Thr Asp  Arg Asp Ser Gly Asp  Gly Gly Leu Val Asn  Tyr Arg Ile 
    1235                 1240                 1245             


Leu Ser  Gly Ala Glu Gly Lys  Phe Glu Ile Asp Glu  Ser Thr Gly 
    1250                 1255                 1260             


Leu Ile  Ile Thr Val Asn Tyr  Leu Asp Tyr Glu Thr  Lys Thr Ser 
    1265                 1270                 1275             


Tyr Met  Met Asn Val Ser Ala  Thr Asp Gln Ala Pro  Pro Phe Asn 
    1280                 1285                 1290             


Gln Gly  Phe Cys Ser Val Tyr  Ile Thr Leu Leu Asn  Glu Leu Asp 
    1295                 1300                 1305             


Glu Ala  Val Gln Phe Ser Asn  Ala Ser Tyr Glu Ala  Ala Ile Leu 
    1310                 1315                 1320             


Glu Asn  Leu Ala Leu Gly Thr  Glu Ile Val Arg Val  Gln Ala Tyr 
    1325                 1330                 1335             


Ser Ile  Asp Asn Leu Asn Gln  Ile Thr Tyr Arg Phe  Asn Ala Tyr 
    1340                 1345                 1350             


Thr Ser  Thr Gln Ala Lys Ala  Leu Phe Lys Ile Asp  Ala Ile Thr 
    1355                 1360                 1365             


Gly Val  Ile Thr Val Gln Gly  Leu Val Asp Arg Glu  Lys Gly Asp 
    1370                 1375                 1380             


Phe Tyr  Thr Leu Thr Val Val  Ala Asp Asp Gly Gly  Pro Lys Val 
    1385                 1390                 1395             


Asp Ser  Thr Val Lys Val Tyr  Ile Thr Val Leu Asp  Glu Asn Asp 
    1400                 1405                 1410             


Asn Ser  Pro Arg Phe Asp Phe  Thr Ser Asp Ser Ala  Val Ser Ile 
    1415                 1420                 1425             


Pro Glu  Asp Cys Pro Val Gly  Gln Arg Val Ala Thr  Val Lys Ala 
    1430                 1435                 1440             


Trp Asp  Pro Asp Ala Gly Ser  Asn Gly Gln Val Val  Phe Ser Leu 
    1445                 1450                 1455             


Ala Ser  Gly Asn Ile Ala Gly  Ala Phe Glu Ile Val  Thr Thr Asn 
    1460                 1465                 1470             


Asp Ser  Ile Gly Glu Val Phe  Val Ala Arg Pro Leu  Asp Arg Glu 
    1475                 1480                 1485             


Glu Leu  Asp His Tyr Ile Leu  Gln Val Val Ala Ser  Asp Arg Gly 
    1490                 1495                 1500             


Thr Pro  Pro Arg Lys Lys Asp  His Ile Leu Gln Val  Thr Ile Leu 
    1505                 1510                 1515             


Asp Ile  Asn Asp Asn Pro Pro  Val Ile Glu Ser Pro  Phe Gly Tyr 
    1520                 1525                 1530             


Asn Val  Ser Val Asn Glu Asn  Val Gly Gly Gly Thr  Ala Val Val 
    1535                 1540                 1545             


Gln Val  Arg Ala Thr Asp Arg  Asp Ile Gly Ile Asn  Ser Val Leu 
    1550                 1555                 1560             


Ser Tyr  Tyr Ile Thr Glu Gly  Asn Lys Asp Met Ala  Phe Arg Met 
    1565                 1570                 1575             


Asp Arg  Ile Ser Gly Glu Ile  Ala Thr Arg Pro Ala  Pro Pro Asp 
    1580                 1585                 1590             


Arg Glu  Arg Gln Ser Phe Tyr  His Leu Val Ala Thr  Val Glu Asp 
    1595                 1600                 1605             


Glu Gly  Thr Pro Thr Leu Ser  Ala Thr Thr His Val  Tyr Val Thr 
    1610                 1615                 1620             


Ile Val  Asp Glu Asn Asp Asn  Ala Pro Met Phe Gln  Gln Pro His 
    1625                 1630                 1635             


Tyr Glu  Val Leu Leu Asp Glu  Gly Pro Asp Thr Leu  Asn Thr Ser 
    1640                 1645                 1650             


Leu Ile  Thr Ile Gln Ala Leu  Asp Leu Asp Glu Gly  Pro Asn Gly 
    1655                 1660                 1665             


Thr Val  Thr Tyr Ala Ile Val  Ala Gly Asn Ile Val  Asn Thr Phe 
    1670                 1675                 1680             


Arg Ile  Asp Arg His Met Gly  Val Ile Thr Ala Ala  Lys Glu Leu 
    1685                 1690                 1695             


Asp Tyr  Glu Ile Ser His Gly  Arg Tyr Thr Leu Ile  Val Thr Ala 
    1700                 1705                 1710             


Thr Asp  Gln Cys Pro Ile Leu  Ser His Arg Leu Thr  Ser Thr Thr 
    1715                 1720                 1725             


Thr Val  Leu Val Asn Val Asn  Asp Ile Asn Asp Asn  Val Pro Thr 
    1730                 1735                 1740             


Phe Pro  Arg Asp Tyr Glu Gly  Pro Phe Glu Val Thr  Glu Gly Gln 
    1745                 1750                 1755             


Pro Gly  Pro Arg Val Trp Thr  Phe Leu Ala His Asp  Arg Asp Ser 
    1760                 1765                 1770             


Gly Pro  Asn Gly Gln Val Glu  Tyr Ser Ile Met Asp  Gly Asp Pro 
    1775                 1780                 1785             


Leu Gly  Glu Phe Val Ile Ser  Pro Val Glu Gly Val  Leu Arg Val 
    1790                 1795                 1800             


Arg Lys  Asp Val Glu Leu Asp  Arg Glu Thr Ile Ala  Phe Tyr Asn 
    1805                 1810                 1815             


Leu Thr  Ile Cys Ala Arg Asp  Arg Gly Met Pro Pro  Leu Ser Ser 
    1820                 1825                 1830             


Thr Met  Leu Val Gly Ile Arg  Val Leu Asp Ile Asn  Asp Asn Asp 
    1835                 1840                 1845             


Pro Val  Leu Leu Asn Leu Pro  Met Asn Ile Thr Ile  Ser Glu Asn 
    1850                 1855                 1860             


Ser Pro  Val Ser Ser Phe Val  Ala His Val Leu Ala  Ser Asp Ala 
    1865                 1870                 1875             


Asp Ser  Gly Cys Asn Ala Arg  Leu Thr Phe Asn Ile  Thr Ala Gly 
    1880                 1885                 1890             


Asn Arg  Glu Arg Ala Phe Phe  Ile Asn Ala Thr Thr  Gly Ile Val 
    1895                 1900                 1905             


Thr Val  Asn Arg Pro Leu Asp  Arg Glu Arg Ile Pro  Glu Tyr Lys 
    1910                 1915                 1920             


Leu Thr  Ile Ser Val Lys Asp  Asn Pro Glu Asn Pro  Arg Ile Ala 
    1925                 1930                 1935             


Arg Arg  Asp Tyr Asp Leu Leu  Leu Ile Phe Leu Ser  Asp Glu Asn 
    1940                 1945                 1950             


Asp Asn  His Pro Leu Phe Thr  Lys Ser Thr Tyr Gln  Ala Glu Val 
    1955                 1960                 1965             


Met Glu  Asn Ser Pro Ala Gly  Thr Pro Leu Thr Val  Leu Asn Gly 
    1970                 1975                 1980             


Pro Ile  Leu Ala Leu Asp Ala  Asp Gln Asp Ile Tyr  Ala Val Val 
    1985                 1990                 1995             


Thr Tyr  Gln Leu Leu Gly Ala  Gln Ser Gly Leu Phe  Asp Ile Asn 
    2000                 2005                 2010             


Ser Ser  Thr Gly Val Val Thr  Val Arg Ser Gly Val  Ile Ile Asp 
    2015                 2020                 2025             


Arg Glu  Ala Phe Ser Pro Pro  Ile Leu Glu Leu Leu  Leu Leu Ala 
    2030                 2035                 2040             


Glu Asp  Ile Gly Leu Leu Asn  Ser Thr Ala His Leu  Leu Ile Thr 
    2045                 2050                 2055             


Ile Leu  Asp Asp Asn Asp Asn  Arg Pro Thr Phe Ser  Pro Ala Thr 
    2060                 2065                 2070             


Leu Thr  Val His Leu Leu Glu  Asn Cys Pro Pro Gly  Phe Ser Val 
    2075                 2080                 2085             


Leu Gln  Val Thr Ala Thr Asp  Glu Asp Ser Gly Leu  Asn Gly Glu 
    2090                 2095                 2100             


Leu Val  Tyr Arg Ile Glu Ala  Gly Ala Gln Asp Arg  Phe Leu Ile 
    2105                 2110                 2115             


His Leu  Val Thr Gly Val Ile  Arg Val Gly Asn Ala  Thr Ile Asp 
    2120                 2125                 2130             


Arg Glu  Glu Gln Glu Ser Tyr  Arg Leu Thr Val Val  Ala Thr Asp 
    2135                 2140                 2145             


Arg Gly  Thr Val Pro Leu Ser  Gly Thr Ala Ile Val  Thr Ile Leu 
    2150                 2155                 2160             


Ile Asp  Asp Ile Asn Asp Ser  Arg Pro Glu Phe Leu  Asn Pro Ile 
    2165                 2170                 2175             


Gln Thr  Val Ser Val Leu Glu  Ser Ala Glu Pro Gly  Thr Val Ile 
    2180                 2185                 2190             


Ala Asn  Ile Thr Ala Ile Asp  His Asp Leu Asn Pro  Lys Leu Glu 
    2195                 2200                 2205             


Tyr His  Ile Val Gly Ile Val  Ala Lys Asp Asp Thr  Asp Arg Leu 
    2210                 2215                 2220             


Val Pro  Asn Gln Glu Asp Ala  Phe Ala Val Asn Ile  Asn Thr Gly 
    2225                 2230                 2235             


Ser Val  Met Val Lys Ser Pro  Met Asn Arg Glu Leu  Val Ala Thr 
    2240                 2245                 2250             


Tyr Glu  Val Thr Leu Ser Val  Ile Asp Asn Ala Ser  Asp Leu Pro 
    2255                 2260                 2265             


Glu Arg  Ser Val Ser Val Pro  Asn Ala Lys Leu Thr  Val Asn Val 
    2270                 2275                 2280             


Leu Asp  Val Asn Asp Asn Thr  Pro Gln Phe Lys Pro  Phe Gly Ile 
    2285                 2290                 2295             


Thr Tyr  Tyr Met Glu Arg Ile  Leu Glu Gly Ala Thr  Pro Gly Thr 
    2300                 2305                 2310             


Thr Leu  Ile Ala Val Ala Ala  Val Asp Pro Asp Lys  Gly Leu Asn 
    2315                 2320                 2325             


Gly Leu  Val Thr Tyr Thr Leu  Leu Asp Leu Val Pro  Pro Gly Tyr 
    2330                 2335                 2340             


Val Gln  Leu Glu Asp Ser Ser  Ala Gly Lys Val Ile  Ala Asn Arg 
    2345                 2350                 2355             


Thr Val  Asp Tyr Glu Glu Val  His Trp Leu Asn Phe  Thr Val Arg 
    2360                 2365                 2370             


Ala Ser  Asp Asn Gly Ser Pro  Pro Arg Ala Ala Glu  Ile Pro Val 
    2375                 2380                 2385             


Tyr Leu  Glu Ile Val Asp Ile  Asn Asp Asn Asn Pro  Ile Phe Asp 
    2390                 2395                 2400             


Gln Pro  Ser Tyr Gln Glu Ala  Val Phe Glu Asp Val  Pro Val Gly 
    2405                 2410                 2415             


Thr Ile  Ile Leu Thr Val Thr  Ala Thr Asp Ala Asp  Ser Gly Asn 
    2420                 2425                 2430             


Phe Ala  Leu Ile Glu Tyr Ser  Leu Gly Asp Gly Glu  Ser Lys Phe 
    2435                 2440                 2445             


Ala Ile  Asn Pro Thr Thr Gly  Asp Ile Tyr Val Leu  Ser Ser Leu 
    2450                 2455                 2460             


Asp Arg  Glu Lys Lys Asp His  Tyr Ile Leu Thr Ala  Leu Ala Lys 
    2465                 2470                 2475             


Asp Asn  Pro Gly Asp Val Ala  Ser Asn Arg Arg Glu  Asn Ser Val 
    2480                 2485                 2490             


Gln Val  Val Ile Gln Val Leu  Asp Val Asn Asp Cys  Arg Pro Gln 
    2495                 2500                 2505             


Phe Ser  Lys Pro Gln Phe Ser  Thr Ser Val Tyr Glu  Asn Glu Pro 
    2510                 2515                 2520             


Ala Gly  Thr Ser Val Ile Thr  Met Met Ala Thr Asp  Gln Asp Glu 
    2525                 2530                 2535             


Gly Pro  Asn Gly Glu Leu Thr  Tyr Ser Leu Glu Gly  Pro Gly Val 
    2540                 2545                 2550             


Glu Ala  Phe His Val Asp Met  Asp Ser Gly Leu Val  Thr Thr Gln 
    2555                 2560                 2565             


Arg Pro  Leu Gln Ser Tyr Glu  Lys Phe Ser Leu Thr  Val Val Ala 
    2570                 2575                 2580             


Thr Asp  Gly Gly Glu Pro Pro  Leu Trp Gly Thr Thr  Met Leu Leu 
    2585                 2590                 2595             


Val Glu  Val Ile Asp Val Asn  Asp Asn Arg Pro Val  Phe Val Arg 
    2600                 2605                 2610             


Pro Pro  Asn Gly Thr Ile Leu  His Ile Arg Glu Glu  Ile Pro Leu 
    2615                 2620                 2625             


Arg Ser  Asn Val Tyr Glu Val  Tyr Ala Thr Asp Lys  Asp Glu Gly 
    2630                 2635                 2640             


Leu Asn  Gly Ala Val Arg Tyr  Ser Phe Leu Lys Thr  Ala Gly Asn 
    2645                 2650                 2655             


Arg Asp  Trp Glu Phe Phe Ile  Ile Asp Pro Ile Ser  Gly Leu Ile 
    2660                 2665                 2670             


Gln Thr  Ala Gln Arg Leu Asp  Arg Glu Ser Gln Ala  Val Tyr Ser 
    2675                 2680                 2685             


Leu Ile  Leu Val Ala Ser Asp  Leu Gly Gln Pro Val  Pro Tyr Glu 
    2690                 2695                 2700             


Thr Met  Gln Pro Leu Gln Val  Ala Leu Glu Asp Ile  Asp Asp Asn 
    2705                 2710                 2715             


Glu Pro  Leu Phe Val Arg Pro  Pro Lys Gly Ser Pro  Gln Tyr Gln 
    2720                 2725                 2730             


Leu Leu  Thr Val Pro Glu His  Ser Pro Arg Gly Thr  Leu Val Gly 
    2735                 2740                 2745             


Asn Val  Thr Gly Ala Val Asp  Ala Asp Glu Gly Pro  Asn Ala Ile 
    2750                 2755                 2760             


Val Tyr  Tyr Phe Ile Ala Ala  Gly Asn Glu Glu Lys  Asn Phe His 
    2765                 2770                 2775             


Leu Gln  Pro Asp Gly Cys Leu  Leu Val Leu Arg Asp  Leu Asp Arg 
    2780                 2785                 2790             


Glu Arg  Glu Ala Ile Phe Ser  Phe Ile Val Lys Ala  Ser Ser Asn 
    2795                 2800                 2805             


Arg Ser  Trp Thr Pro Pro Arg  Gly Pro Ser Pro Thr  Leu Asp Leu 
    2810                 2815                 2820             


Val Ala  Asp Leu Thr Leu Gln  Glu Val Arg Val Val  Leu Glu Asp 
    2825                 2830                 2835             


Ile Asn  Asp Gln Pro Pro Arg  Phe Thr Lys Ala Glu  Tyr Thr Ala 
    2840                 2845                 2850             


Gly Val  Ala Thr Asp Ala Lys  Val Gly Ser Glu Leu  Ile Gln Val 
    2855                 2860                 2865             


Leu Ala  Leu Asp Ala Asp Ile  Gly Asn Asn Ser Leu  Val Phe Tyr 
    2870                 2875                 2880             


Ser Ile  Leu Ala Ile His Tyr  Phe Arg Ala Leu Ala  Asn Asp Ser 
    2885                 2890                 2895             


Glu Asp  Val Gly Gln Val Phe  Thr Met Gly Ser Met  Asp Gly Ile 
    2900                 2905                 2910             


Leu Arg  Thr Phe Asp Leu Phe  Met Ala Tyr Ser Pro  Gly Tyr Phe 
    2915                 2920                 2925             


Val Val  Asp Ile Val Ala Arg  Asp Leu Ala Gly His  Asn Asp Thr 
    2930                 2935                 2940             


Ala Ile  Ile Gly Ile Tyr Ile  Leu Arg Asp Asp Gln  Arg Val Lys 
    2945                 2950                 2955             


Ile Val  Ile Asn Glu Ile Pro  Asp Arg Val Arg Gly  Phe Glu Glu 
    2960                 2965                 2970             


Glu Phe  Ile His Leu Leu Ser  Asn Ile Thr Gly Ala  Ile Val Asn 
    2975                 2980                 2985             


Thr Asp  Asn Val Gln Phe His  Val Asp Lys Lys Gly  Arg Val Asn 
    2990                 2995                 3000             


Phe Ala  Gln Thr Glu Leu Leu  Ile His Val Val Asn  Arg Asp Thr 
    3005                 3010                 3015             


Asn Arg  Ile Leu Asp Val Asp  Arg Val Ile Gln Met  Ile Asp Glu 
    3020                 3025                 3030             


Asn Lys  Glu Gln Leu Arg Asn  Leu Phe Arg Asn Tyr  Asn Val Leu 
    3035                 3040                 3045             


Asp Val  Gln Pro Ala Ile Ser  Val Arg Leu Pro Asp  Asp Met Ser 
    3050                 3055                 3060             


Ala Leu  Gln Met Ala Ile Ile  Val Leu Ala Ile Leu  Leu Phe Leu 
    3065                 3070                 3075             


Ala Ala  Met Leu Phe Val Leu  Met Asn Trp Tyr Tyr  Arg Thr Val 
    3080                 3085                 3090             


His Lys  Arg Lys Leu Lys Ala  Ile Val Ala Gly Ser  Ala Gly Asn 
    3095                 3100                 3105             


Arg Gly  Phe Ile Asp Ile Met  Asp Met Pro Asn Thr  Asn Lys Tyr 
    3110                 3115                 3120             


Ser Phe  Asp Gly Ala Asn Pro  Val Trp Leu Asp Pro  Phe Cys Arg 
    3125                 3130                 3135             


Asn Leu  Glu Leu Ala Ala Gln  Ala Glu His Glu Asp  Asp Leu Pro 
    3140                 3145                 3150             


Glu Asn  Leu Ser Glu Ile Ala  Asp Leu Trp Asn Ser  Pro Thr Arg 
    3155                 3160                 3165             


Thr His  Gly Thr Phe Gly Arg  Glu Pro Ala Ala Val  Lys Pro Asp 
    3170                 3175                 3180             


Asp Asp  Arg Tyr Leu Arg Ala  Ala Ile Gln Glu Tyr  Asp Asn Ile 
    3185                 3190                 3195             


Ala Lys  Leu Gly Gln Ile Ile  Arg Glu Gly Pro Ile  Lys Gly Ser 
    3200                 3205                 3210             


Leu Leu  Lys Val Val Leu Glu  Asp Tyr Leu Arg Leu  Lys Lys Leu 
    3215                 3220                 3225             


Phe Ala  Gln Arg Met Val Gln  Lys Ala Ser Ser Cys  His Ser Ser 
    3230                 3235                 3240             


Ile Ser  Glu Leu Ile Gln Thr  Glu Leu Asp Glu Glu  Pro Gly Asp 
    3245                 3250                 3255             


His Ser  Pro Gly Gln Gly Ser  Leu Arg Phe Arg His  Lys Pro Pro 
    3260                 3265                 3270             


Val Glu  Leu Lys Gly Pro Asp  Gly Ile His Val Val  His Gly Ser 
    3275                 3280                 3285             


Thr Gly  Thr Leu Leu Ala Thr  Asp Leu Asn Ser Leu  Pro Glu Glu 
    3290                 3295                 3300             


Asp Gln  Lys Gly Leu Gly Arg  Ser Leu Glu Thr Leu  Thr Ala Ala 
    3305                 3310                 3315             


Glu Ala  Thr Ala Phe Glu Arg  Asn Ala Arg Thr Glu  Ser Ala Lys 
    3320                 3325                 3330             


Ser Thr  Pro Leu His Lys Leu  Arg Asp Val Ile Met  Glu Thr Pro 
    3335                 3340                 3345             


Leu Glu  Ile Thr Glu Leu 
    3350                 


<210>  69
<211>  699
<212>  DNA
<213>  Homo sapiens

<400>  69
atgccaagcc aacagaagaa aatcattttt tgcatggccg gagtgttcag ttttgcatgt       60

gccctcggag ttgtgacagc cttggggaca ccgttgtgga tcaaagccac tgtcctctgc      120

aaaacgggag ctctgctcgt caatgcctca gggcaggagc tggacaagtt tatgggtgaa      180

atgcagtacg ggcttttcca cggagagggt gtgaggcagt gtgggttggg agcaaggccc      240

tttcggttct cattttttcc agatttgctc aaagcaatcc cagtgagcat ccacgtcaat      300

gtcattctct tctctgccat ccttattgtg ttaaccatgg tggggacagc cttcttcatg      360

tacaatgctt ttggaaaacc ttttgaaact ctgcatggtc ccctagggct gtaccttttg      420

agcttcattt caggctcctg tggctgtctt gtcatgatat tgtttgcctc tgaagtgaaa      480

atccatcacc tctcagaaaa aattgcaaat tataaagaag ggacttatgt ctacaaaacg      540

caaagtgaaa aatataccac ctcattctgg gtcattttct tttgcttttt tgttcatttt      600

ctgaatgggc tcctaatacg acttgctgga tttcagttcc cttttgcaaa atctaaagac      660

gcagaaacaa ctaatgtagc tgcagatcta atgtactga                             699


<210>  70
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Pro Ser Gln Gln Lys Lys Ile Ile Phe Cys Met Ala Gly Val Phe 
1               5                   10                  15      


Ser Phe Ala Cys Ala Leu Gly Val Val Thr Ala Leu Gly Thr Pro Leu 
            20                  25                  30          


Trp Ile Lys Ala Thr Val Leu Cys Lys Thr Gly Ala Leu Leu Val Asn 
        35                  40                  45              


Ala Ser Gly Gln Glu Leu Asp Lys Phe Met Gly Glu Met Gln Tyr Gly 
    50                  55                  60                  


Leu Phe His Gly Glu Gly Val Arg Gln Cys Gly Leu Gly Ala Arg Pro 
65                  70                  75                  80  


Phe Arg Phe Ser Phe Phe Pro Asp Leu Leu Lys Ala Ile Pro Val Ser 
                85                  90                  95      


Ile His Val Asn Val Ile Leu Phe Ser Ala Ile Leu Ile Val Leu Thr 
            100                 105                 110         


Met Val Gly Thr Ala Phe Phe Met Tyr Asn Ala Phe Gly Lys Pro Phe 
        115                 120                 125             


Glu Thr Leu His Gly Pro Leu Gly Leu Tyr Leu Leu Ser Phe Ile Ser 
    130                 135                 140                 


Gly Ser Cys Gly Cys Leu Val Met Ile Leu Phe Ala Ser Glu Val Lys 
145                 150                 155                 160 


Ile His His Leu Ser Glu Lys Ile Ala Asn Tyr Lys Glu Gly Thr Tyr 
                165                 170                 175     


Val Tyr Lys Thr Gln Ser Glu Lys Tyr Thr Thr Ser Phe Trp Val Ile 
            180                 185                 190         


Phe Phe Cys Phe Phe Val His Phe Leu Asn Gly Leu Leu Ile Arg Leu 
        195                 200                 205             


Ala Gly Phe Gln Phe Pro Phe Ala Lys Ser Lys Asp Ala Glu Thr Thr 
    210                 215                 220                 


Asn Val Ala Ala Asp Leu Met Tyr 
225                 230         


<210>  71
<211>  2211
<212>  DNA
<213>  Adeno-associated virus-1

<400>  71
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg atccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210>  72
<211>  2208
<212>  DNA
<213>  adeno-associated virus 2

<400>  72
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  73
<211>  2175
<212>  DNA
<213>  Adeno-associated virus 5

<400>  73
atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag       60

tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa      120

gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga      180

ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag      240

cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag      300

gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc      360

aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc      420

ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc      480

aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc      540

ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca      600

ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc      660

gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc      720

agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc      780

aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc      840

cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg      900

tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc      960

accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag     1020

ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc     1080

tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc     1140

gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac     1200

aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt     1260

cagaacctgt tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc     1320

acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc     1380

tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg     1440

gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg     1500

agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc     1560

tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc     1620

acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc     1680

gtggcgtaca acgtcggcgg gcagatggcc accaacaacc agagctccac cactgccccc     1740

gcgaccggca cgtacaacct ccaggaaatc gtgcccggca gcgtgtggat ggagagggac     1800

gtgtacctcc aaggacccat ctgggccaag atcccagaga cgggggcgca ctttcacccc     1860

tctccggcca tgggcggatt cggactcaaa cacccaccgc ccatgatgct catcaagaac     1920

acgcctgtgc ccggaaatat caccagcttc tcggacgtgc ccgtcagcag cttcatcacc     1980

cagtacagca ccgggcaggt caccgtggag atggagtggg agctcaagaa ggaaaactcc     2040

aagaggtgga acccagagat ccagtacaca aacaactaca acgaccccca gtttgtggac     2100

tttgccccgg acagcaccgg ggaatacaga accaccagac ctatcggaac ccgatacctt     2160

acccgacccc tttaa                                                      2175


<210>  74
<211>  2217
<212>  DNA
<213>  Adeno-associated virus 8

<400>  74
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgca gcagcaaaac acggctcctc aaattggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctgtaa        2217


