                         SEQUENCE LISTING

<110>  Amgen Inc.
 
<120>  Anti-RANKL Antibody Combinations Comprising Cyclin-Dependent 
       Kinase (CDK) Inhibitors

<130>  01017/53978A/PC

<150>  US 62/840,810
<151>  2019-04-30

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  denosumab variable light chain

<400>  1

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Gly Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Phe Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  2
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  denosumab variable heavy chain

<400>  2

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Pro Gly Thr Thr Val Ile Met Ser Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  3
<211>  235
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  denosumab full length light chain

<400>  3

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Arg Gly Arg Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Phe Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Ser Ser Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  4
<211>  467
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  denosumab full length heavy chain

<400>  4

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Gly Ile Thr Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Asp Pro Gly Thr Thr Val Ile Met Ser Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  5
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Light Chain CDR 1

<400>  5

Arg Ala Ser Gln Ser Val Arg Gly Arg Tyr Leu Ala 
1               5                   10          


<210>  6
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Light Chain CDR 2

<400>  6

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  7
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Light Chain CDR 3

<400>  7

Gln Gln Tyr Gly Ser Ser Pro Arg Thr 
1               5                   


<210>  8
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Heavy Chain CDR 1

<400>  8

Ser Tyr Ala Met Ser 
1               5   


<210>  9
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Heavy Chain CDR 2

<400>  9

Gly Ile Thr Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  10
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Heavy Chain CDR 3

<400>  10

Asp Pro Gly Thr Thr Val Ile Met Ser Trp Phe Asp Pro 
1               5                   10              


<210>  11
<211>  2141
<212>  DNA
<213>  Homo sapiens

<400>  11
ggccaaagcc gggctccaag tcggcgcccc acgtcgaggc tccgccgcag cctccggagt       60

tggccgcaga caagaagggg agggagcggg agagggagga gagctccgaa gcgagagggc      120

cgagcgccat gcgccgcgcc agcagagact acaccaagta cctgcgtggc tcggaggaga      180

tgggcggcgg ccccggagcc ccgcacgagg gccccctgca cgccccgccg ccgcctgcgc      240

cgcaccagcc ccccgccgcc tcccgctcca tgttcgtggc cctcctgggg ctggggctgg      300

gccaggttgt ctgcagcgtc gccctgttct tctatttcag agcgcagatg gatcctaata      360

gaatatcaga agatggcact cactgcattt atagaatttt gagactccat gaaaatgcag      420

attttcaaga cacaactctg gagagtcaag atacaaaatt aatacctgat tcatgtagga      480

gaattaaaca ggcctttcaa ggagctgtgc aaaaggaatt acaacatatc gttggatcac      540

agcacatcag agcagagaaa gcgatggtgg atggctcatg gttagatctg gccaagagga      600

gcaagcttga agctcagcct tttgctcatc tcactattaa tgccaccgac atcccatctg      660

gttcccataa agtgagtctg tcctcttggt accatgatcg gggttgggcc aagatctcca      720

acatgacttt tagcaatgga aaactaatag ttaatcagga tggcttttat tacctgtatg      780

ccaacatttg ctttcgacat catgaaactt caggagacct agctacagag tatcttcaac      840

taatggtgta cgtcactaaa accagcatca aaatcccaag ttctcatacc ctgatgaaag      900

gaggaagcac caagtattgg tcagggaatt ctgaattcca tttttattcc ataaacgttg      960

gtggattttt taagttacgg tctggagagg aaatcagcat cgaggtctcc aacccctcct     1020

tactggatcc ggatcaggat gcaacatact ttggggcttt taaagttcga gatatagatt     1080

gagccccagt ttttggagtg ttatgtattt cctggatgtt tggaaacatt ttttaaaaca     1140

agccaagaaa gatgtatata ggtgtgtgag actactaaga ggcatggccc caacggtaca     1200

cgactcagta tccatgctct tgaccttgta gagaacacgc gtatttacct gccagtggga     1260

gatgttagac tcatggtgtg ttacacaatg gtttttaaat tttgtaatga attcctagaa     1320

ttaaaccaga ttggagcaat tacgggttga ccttatgaga aactgcatgt gggctatggg     1380

aggggttggt ccctggtcat gtgccccttc gcagctgaag tggagagggt gtcatctagc     1440

gcaattgaag gatcatctga aggggcaaat tcttttgaat tgttacatca tgctggaacc     1500

tgcaaaaaat actttttcta atgaggagag aaaatatatg tatttttata taatatctaa     1560

agttatattt cagatgtaat gttttctttg caaagtattg taaattatat ttgtgctata     1620

acagacatat ttaactggtg cactttgtaa attccctggg gaaaacttgc agctaaggag     1680

gggaaaaaaa tgttgtttcc taatatcaaa tgcagtatat ttcttcgttc tttttaagtt     1740

aatagatttt ttcagacttg tcaagcctgt gcaaaaaaat taaaatggat gccttgaata     1800

ataagcagga tgttggccac caggtgcctt tcaaatttag aaactaattg actttagaaa     1860

gctgacattg ccaaaaagga tacataatgg gccactgaaa tttgtcaaga gtagttatat     1920

aattgttgaa caggtgtttt tccacaagtg ccgcaaattg tacctttttt tttttttcaa     1980

aatagaaaag ttattagtgg tttatcagca aaaaagtcca attttaattt agtaaatgtt     2040

attttatact gtacaataaa aacattgcct ttgaatgtta attttttggt acaaaaataa     2100

atttatatga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                         2141


<210>  12
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Arg Arg Ala Ser Arg Asp Tyr Thr Lys Tyr Leu Arg Gly Ser Glu 
1               5                   10                  15      


Glu Met Gly Gly Gly Pro Gly Ala Pro His Glu Gly Pro Leu His Ala 
            20                  25                  30          


Pro Pro Pro Pro Ala Pro His Gln Pro Pro Ala Ala Ser Arg Ser Met 
        35                  40                  45              


Phe Val Ala Leu Leu Gly Leu Gly Leu Gly Gln Val Val Cys Ser Val 
    50                  55                  60                  


Ala Leu Phe Phe Tyr Phe Arg Ala Gln Met Asp Pro Asn Arg Ile Ser 
65                  70                  75                  80  


Glu Asp Gly Thr His Cys Ile Tyr Arg Ile Leu Arg Leu His Glu Asn 
                85                  90                  95      


Ala Asp Phe Gln Asp Thr Thr Leu Glu Ser Gln Asp Thr Lys Leu Ile 
            100                 105                 110         


Pro Asp Ser Cys Arg Arg Ile Lys Gln Ala Phe Gln Gly Ala Val Gln 
        115                 120                 125             


Lys Glu Leu Gln His Ile Val Gly Ser Gln His Ile Arg Ala Glu Lys 
    130                 135                 140                 


Ala Met Val Asp Gly Ser Trp Leu Asp Leu Ala Lys Arg Ser Lys Leu 
145                 150                 155                 160 


Glu Ala Gln Pro Phe Ala His Leu Thr Ile Asn Ala Thr Asp Ile Pro 
                165                 170                 175     


Ser Gly Ser His Lys Val Ser Leu Ser Ser Trp Tyr His Asp Arg Gly 
            180                 185                 190         


Trp Ala Lys Ile Ser Asn Met Thr Phe Ser Asn Gly Lys Leu Ile Val 
        195                 200                 205             


Asn Gln Asp Gly Phe Tyr Tyr Leu Tyr Ala Asn Ile Cys Phe Arg His 
    210                 215                 220                 


His Glu Thr Ser Gly Asp Leu Ala Thr Glu Tyr Leu Gln Leu Met Val 
225                 230                 235                 240 


Tyr Val Thr Lys Thr Ser Ile Lys Ile Pro Ser Ser His Thr Leu Met 
                245                 250                 255     


Lys Gly Gly Ser Thr Lys Tyr Trp Ser Gly Asn Ser Glu Phe His Phe 
            260                 265                 270         


Tyr Ser Ile Asn Val Gly Gly Phe Phe Lys Leu Arg Ser Gly Glu Glu 
        275                 280                 285             


Ile Ser Ile Glu Val Ser Asn Pro Ser Leu Leu Asp Pro Asp Gln Asp 
    290                 295                 300                 


Ala Thr Tyr Phe Gly Ala Phe Lys Val Arg Asp Ile Asp 
305                 310                 315         


<210>  13
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Gly Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Phe Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  14
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Pro Gly Thr Thr Val Ile Met Ser Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
    210                 215                 220                 


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  15
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa is Cys or Ser

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is Arg or Lys

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa is Glu or Gly

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa is Ser or Gly

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa is Ser or Asn

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa is Leu or Phe

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  Xaa is Lys or Gln

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa is Thr or Ile

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa is Asp or Asn

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa is Arg, Thr, or Lys

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa is Ser, Arg, or Pro

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa is Tyr, Cys, or Ser

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa is Gly or Cys

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa is absent or Asp

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa is absent or Lys

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa is absent or Thr

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa is Pro, Val or His

<220>
<221>  misc_feature
<222>  (108)..(108)
<223>  Xaa is Pro, Glu, or Thr

<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  Xaa is Ser or Pro

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  Xaa is Glu or Pro

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  Xaa is Phe, Val, or Leu

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  Xaa is Leu or Ala

<220>
<221>  misc_feature
<222>  (120)..(120)
<223>  Xaa is absent or Gly

<220>
<221>  misc_feature
<222>  (151)..(151)
<223>  Xaa is Gln or His

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  Xaa is Gln or Lys

<220>
<221>  misc_feature
<222>  (179)..(179)
<223>  Xaa is Phe or Tyr

<220>
<221>  misc_feature
<222>  (183)..(183)
<223>  Xaa is Tyr or Phe

<220>
<221>  misc_feature
<222>  (192)..(192)
<223>  Xaa is Leu or Val

<220>
<221>  misc_feature
<222>  (210)..(210)
<223>  Xaa is Gly or Ala

<220>
<221>  misc_feature
<222>  (213)..(213)
<223>  Xaa is Ser or Ala

<220>
<221>  misc_feature
<222>  (214)..(214)
<223>  Xaa is Ser or Pro

<220>
<221>  misc_feature
<222>  (222)..(222)
<223>  Xaa is Ala or Thr

<220>
<221>  misc_feature
<222>  (238)..(238)
<223>  Xaa is Gln or Arg

<220>
<221>  misc_feature
<222>  (239)..(239)
<223>  Xaa is Glu or Asp

<220>
<221>  misc_feature
<222>  (241)..(241)
<223>  Xaa is Met or Leu

<220>
<221>  misc_feature
<222>  (280)..(280)
<223>  Xaa is Val or Met

<220>
<221>  misc_feature
<222>  (292)..(292)
<223>  Xaa is Arg or Lys

<220>
<221>  misc_feature
<222>  (302)..(302)
<223>  Xaa is Glu or Gln

<220>
<221>  misc_feature
<222>  (328)..(328)
<223>  Xaa is Leu or Pro

<400>  15

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Xaa Ser Xaa 
1               5                   10                  15      


Ser Thr Ser Xaa Xaa Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Xaa Xaa Gly Thr Xaa Thr 
65                  70                  75                  80  


Tyr Xaa Cys Asn Val Xaa His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Xaa Val Glu Xaa Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Pro Xaa Cys 
            100                 105                 110         


Pro Ala Pro Xaa Xaa Xaa Gly Xaa Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser Xaa Glu Asp Pro Glu Val Xaa Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Xaa Asn Ser Thr Xaa Arg Val Val Ser Val Leu Thr Val Xaa 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Xaa Leu Pro Xaa Xaa Ile Glu Lys Thr Ile Ser Lys Xaa Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Xaa Xaa Glu 
225                 230                 235                 240 


Xaa Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Xaa Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Xaa Leu Thr Val Asp Lys Ser Arg Trp Gln Xaa Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Xaa Gly Lys 
                325                 330 


<210>  16
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  IgG2 Constant HC

<400>  16

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  17
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  IgG1 constant HC

<400>  17

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  18
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  IgG4 constant HC

<400>  18

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  19
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  variable LC

<400>  19
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgta gggccagtca gagtgttcgc ggcaggtact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgtt ttactgtcag cagtatggta gttcacctcg gacgttcggc      300

caagggacca aggtggaaat caaa                                             324


<210>  20
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  variable HC

<400>  20
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaggt attactggga gtggtggtag tacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagatcca      300

gggactacgg tgattatgag ttggttcgac ccctggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  21
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  full length LC

<400>  21
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgta gggccagtca gagtgttcgc ggcaggtact tagcctggta ccagcagaaa      180

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgtt ttactgtcag cagtatggta gttcacctcg gacgttcggc      360

caagggacca aggtggaaat caaacgaact gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      705


<210>  22
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  full length HC

<400>  22
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgtgag       60

gtgcagctgt tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc      120

tgtgcagcct ctggattcac ctttagcagc tatgccatga gctgggtccg ccaggctcca      180

gggaaggggc tggagtgggt ctcaggtatt actgggagtg gtggtagtac atactacgca      240

gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg      300

caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa agatccaggg      360

actacggtga ttatgagttg gttcgacccc tggggccagg gaaccctggt caccgtctcc      420

tcagcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      480

gagagcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag      660

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag      720

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgtggcagg accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg      840

tgcgtggtgg tggacgtgag ccacgaagac cccgaggtcc agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc      960

cgtgtggtca gcgtcctcac cgttgtgcac caggactggc tgaacggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagg cctcccagcc cccatcgaga aaaccatctc caaaaccaaa     1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc     1260

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ctccgggtaa a                                               1401


<210>  23
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  mature LC

<400>  23
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgta gggccagtca gagtgttcgc ggcaggtact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgtt ttactgtcag cagtatggta gttcacctcg gacgttcggc      300

caagggacca aggtggaaat caaacgaact gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  24
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  mature HC

<400>  24
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaggt attactggga gtggtggtag tacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagatcca      300

gggactacgg tgattatgag ttggttcgac ccctggggcc agggaaccct ggtcaccgtc      360

tcctcagcct ccaccaaggg cccatcggtc ttccccctgg cgccctgctc caggagcacc      420

tccgagagca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc tctgaccagc ggcgtgcaca ccttcccagc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcaa cttcggcacc      600

cagacctaca cctgcaacgt agatcacaag cccagcaaca ccaaggtgga caagacagtt      660

gagcgcaaat gttgtgtcga gtgcccaccg tgcccagcac cacctgtggc aggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acgtgcgtgg tggtggacgt gagccacgaa gaccccgagg tccagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccacggg aggagcagtt caacagcacg      900

ttccgtgtgg tcagcgtcct caccgttgtg caccaggact ggctgaacgg caaggagtac      960

aagtgcaagg tctccaacaa aggcctccca gcccccatcg agaaaaccat ctccaaaacc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacacctcc catgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  signal peptide of full length LC of SEQ 3

<400>  25

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  26
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  signal peptide of full length HC of SEQ 4

<400>  26

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  27

Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210>  28
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  28

Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
1               5                   10                  15      


Ser Gln Ser Val Arg Gly Arg Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
            20                  25                  30          


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
        35                  40                  45              


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    50                  55                  60                  


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Phe Tyr Cys 
65                  70                  75                  80  


Gln Gln Tyr Gly Ser Ser Pro Arg Thr Phe Gly Gln Gly Thr Lys Val 
                85                  90                  95      


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
            100                 105                 110         


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
        115                 120                 125             


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
    130                 135                 140                 


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
145                 150                 155                 160 


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
                165                 170                 175     


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
            180                 185                 190         


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
        195                 200                 205     


<210>  29
<211>  616
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu Leu 
1               5                   10                  15      


Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile Ala Pro 
            20                  25                  30          


Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg Cys Cys Asn 
        35                  40                  45              


Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys Thr Thr Thr Ser 
    50                  55                  60                  


Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu Tyr Leu Asp Ser Trp 
65                  70                  75                  80  


Asn Glu Glu Asp Lys Cys Leu Leu His Lys Val Cys Asp Thr Gly Lys 
                85                  90                  95      


Ala Leu Val Ala Val Val Ala Gly Asn Ser Thr Thr Pro Arg Arg Cys 
            100                 105                 110         


Ala Cys Thr Ala Gly Tyr His Trp Ser Gln Asp Cys Glu Cys Cys Arg 
        115                 120                 125             


Arg Asn Thr Glu Cys Ala Pro Gly Leu Gly Ala Gln His Pro Leu Gln 
    130                 135                 140                 


Leu Asn Lys Asp Thr Val Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser 
145                 150                 155                 160 


Asp Ala Phe Ser Ser Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr 
                165                 170                 175     


Phe Leu Gly Lys Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala 
            180                 185                 190         


Val Cys Ser Ser Ser Leu Pro Ala Arg Lys Pro Pro Asn Glu Pro His 
        195                 200                 205             


Val Tyr Leu Pro Gly Leu Ile Ile Leu Leu Leu Phe Ala Ser Val Ala 
    210                 215                 220                 


Leu Val Ala Ala Ile Ile Phe Gly Val Cys Tyr Arg Lys Lys Gly Lys 
225                 230                 235                 240 


Ala Leu Thr Ala Asn Leu Trp His Trp Ile Asn Glu Ala Cys Gly Arg 
                245                 250                 255     


Leu Ser Gly Asp Lys Glu Ser Ser Gly Asp Ser Cys Val Ser Thr His 
            260                 265                 270         


Thr Ala Asn Phe Gly Gln Gln Gly Ala Cys Glu Gly Val Leu Leu Leu 
        275                 280                 285             


Thr Leu Glu Glu Lys Thr Phe Pro Glu Asp Met Cys Tyr Pro Asp Gln 
    290                 295                 300                 


Gly Gly Val Cys Gln Gly Thr Cys Val Gly Gly Gly Pro Tyr Ala Gln 
305                 310                 315                 320 


Gly Glu Asp Ala Arg Met Leu Ser Leu Val Ser Lys Thr Glu Ile Glu 
                325                 330                 335     


Glu Asp Ser Phe Arg Gln Met Pro Thr Glu Asp Glu Tyr Met Asp Arg 
            340                 345                 350         


Pro Ser Gln Pro Thr Asp Gln Leu Leu Phe Leu Thr Glu Pro Gly Ser 
        355                 360                 365             


Lys Ser Thr Pro Pro Phe Ser Glu Pro Leu Glu Val Gly Glu Asn Asp 
    370                 375                 380                 


Ser Leu Ser Gln Cys Phe Thr Gly Thr Gln Ser Thr Val Gly Ser Glu 
385                 390                 395                 400 


Ser Cys Asn Cys Thr Glu Pro Leu Cys Arg Thr Asp Trp Thr Pro Met 
                405                 410                 415     


Ser Ser Glu Asn Tyr Leu Gln Lys Glu Val Asp Ser Gly His Cys Pro 
            420                 425                 430         


His Trp Ala Ala Ser Pro Ser Pro Asn Trp Ala Asp Val Cys Thr Gly 
        435                 440                 445             


Cys Arg Asn Pro Pro Gly Glu Asp Cys Glu Pro Leu Val Gly Ser Pro 
    450                 455                 460                 


Lys Arg Gly Pro Leu Pro Gln Cys Ala Tyr Gly Met Gly Leu Pro Pro 
465                 470                 475                 480 


Glu Glu Glu Ala Ser Arg Thr Glu Ala Arg Asp Gln Pro Glu Asp Gly 
                485                 490                 495     


Ala Asp Gly Arg Leu Pro Ser Ser Ala Arg Ala Gly Ala Gly Ser Gly 
            500                 505                 510         


Ser Ser Pro Gly Gly Gln Ser Pro Ala Ser Gly Asn Val Thr Gly Asn 
        515                 520                 525             


Ser Asn Ser Thr Phe Ile Ser Ser Gly Gln Val Met Asn Phe Lys Gly 
    530                 535                 540                 


Asp Ile Ile Val Val Tyr Val Ser Gln Thr Ser Gln Glu Gly Ala Ala 
545                 550                 555                 560 


Ala Ala Ala Glu Pro Met Gly Arg Pro Val Gln Glu Glu Thr Leu Ala 
                565                 570                 575     


Arg Arg Asp Ser Phe Ala Gly Asn Gly Pro Arg Phe Pro Asp Pro Cys 
            580                 585                 590         


Gly Gly Pro Glu Gly Leu Arg Glu Pro Glu Lys Ala Ser Arg Pro Val 
        595                 600                 605             


Gln Glu Gln Gly Gly Ala Lys Ala 
    610                 615     


<210>  30
<211>  8148
<212>  PRT
<213>  Homo sapiens

<400>  30

Ala Gly Ala Gly Gly Cys Cys Gly Cys Thr Gly Ala Gly Gly Cys Cys 
1               5                   10                  15      


Gly Cys Gly Gly Cys Gly Cys Cys Cys Gly Cys Cys Ala Gly Cys Cys 
            20                  25                  30          


Thr Gly Thr Cys Cys Cys Gly Cys Gly Cys Cys Ala Thr Gly Gly Cys 
        35                  40                  45              


Cys Cys Cys Gly Cys Gly Cys Gly Cys Cys Cys Gly Gly Cys Gly Gly 
    50                  55                  60                  


Cys Gly Cys Cys Gly Cys Cys Cys Gly Cys Thr Gly Thr Thr Cys Gly 
65                  70                  75                  80  


Cys Gly Cys Thr Gly Cys Thr Gly Cys Thr Gly Cys Thr Cys Thr Gly 
                85                  90                  95      


Cys Gly Cys Gly Cys Thr Gly Cys Thr Cys Gly Cys Cys Cys Gly Gly 
            100                 105                 110         


Cys Thr Gly Cys Ala Gly Gly Thr Gly Gly Cys Thr Thr Thr Gly Cys 
        115                 120                 125             


Ala Gly Ala Thr Cys Gly Cys Thr Cys Cys Thr Cys Cys Ala Thr Gly 
    130                 135                 140                 


Thr Ala Cys Cys Ala Gly Thr Gly Ala Gly Ala Ala Gly Cys Ala Thr 
145                 150                 155                 160 


Thr Ala Thr Gly Ala Gly Cys Ala Thr Cys Thr Gly Gly Gly Ala Cys 
                165                 170                 175     


Gly Gly Thr Gly Cys Thr Gly Thr Ala Ala Cys Ala Ala Ala Thr Gly 
            180                 185                 190         


Thr Gly Ala Ala Cys Cys Ala Gly Gly Ala Ala Ala Gly Thr Ala Cys 
        195                 200                 205             


Ala Thr Gly Thr Cys Thr Thr Cys Thr Ala Ala Ala Thr Gly Cys Ala 
    210                 215                 220                 


Cys Thr Ala Cys Thr Ala Cys Cys Thr Cys Thr Gly Ala Cys Ala Gly 
225                 230                 235                 240 


Thr Gly Thr Ala Thr Gly Thr Cys Thr Gly Cys Cys Cys Thr Gly Thr 
                245                 250                 255     


Gly Gly Cys Cys Cys Gly Gly Ala Thr Gly Ala Ala Thr Ala Cys Thr 
            260                 265                 270         


Thr Gly Gly Ala Thr Ala Gly Cys Thr Gly Gly Ala Ala Thr Gly Ala 
        275                 280                 285             


Ala Gly Ala Ala Gly Ala Thr Ala Ala Ala Thr Gly Cys Thr Thr Gly 
    290                 295                 300                 


Cys Thr Gly Cys Ala Thr Ala Ala Ala Gly Thr Thr Thr Gly Thr Gly 
305                 310                 315                 320 


Ala Thr Ala Cys Ala Gly Gly Cys Ala Ala Gly Gly Cys Cys Cys Thr 
                325                 330                 335     


Gly Gly Thr Gly Gly Cys Cys Gly Thr Gly Gly Thr Cys Gly Cys Cys 
            340                 345                 350         


Gly Gly Cys Ala Ala Cys Ala Gly Cys Ala Cys Gly Ala Cys Cys Cys 
        355                 360                 365             


Cys Cys Cys Gly Gly Cys Gly Cys Thr Gly Cys Gly Cys Gly Thr Gly 
    370                 375                 380                 


Cys Ala Cys Gly Gly Cys Thr Gly Gly Gly Thr Ala Cys Cys Ala Cys 
385                 390                 395                 400 


Thr Gly Gly Ala Gly Cys Cys Ala Gly Gly Ala Cys Thr Gly Cys Gly 
                405                 410                 415     


Ala Gly Thr Gly Cys Thr Gly Cys Cys Gly Cys Cys Gly Cys Ala Ala 
            420                 425                 430         


Cys Ala Cys Cys Gly Ala Gly Thr Gly Cys Gly Cys Gly Cys Cys Gly 
        435                 440                 445             


Gly Gly Cys Cys Thr Gly Gly Gly Cys Gly Cys Cys Cys Ala Gly Cys 
    450                 455                 460                 


Ala Cys Cys Cys Gly Thr Thr Gly Cys Ala Gly Cys Thr Cys Ala Ala 
465                 470                 475                 480 


Cys Ala Ala Gly Gly Ala Cys Ala Cys Ala Gly Thr Gly Thr Gly Cys 
                485                 490                 495     


Ala Ala Ala Cys Cys Thr Thr Gly Cys Cys Thr Thr Gly Cys Ala Gly 
            500                 505                 510         


Gly Cys Thr Ala Cys Thr Thr Cys Thr Cys Thr Gly Ala Thr Gly Cys 
        515                 520                 525             


Cys Thr Thr Thr Thr Cys Cys Thr Cys Cys Ala Cys Gly Gly Ala Cys 
    530                 535                 540                 


Ala Ala Ala Thr Gly Cys Ala Gly Ala Cys Cys Cys Thr Gly Gly Ala 
545                 550                 555                 560 


Cys Cys Ala Ala Cys Thr Gly Thr Ala Cys Cys Thr Thr Cys Cys Thr 
                565                 570                 575     


Thr Gly Gly Ala Ala Ala Gly Ala Gly Ala Gly Thr Ala Gly Ala Ala 
            580                 585                 590         


Cys Ala Thr Cys Ala Thr Gly Gly Gly Ala Cys Ala Gly Ala Gly Ala 
        595                 600                 605             


Ala Ala Thr Cys Cys Gly Ala Thr Gly Cys Gly Gly Thr Thr Thr Gly 
    610                 615                 620                 


Cys Ala Gly Thr Thr Cys Thr Thr Cys Thr Cys Thr Gly Cys Cys Ala 
625                 630                 635                 640 


Gly Cys Thr Ala Gly Ala Ala Ala Ala Cys Cys Ala Cys Cys Ala Ala 
                645                 650                 655     


Ala Thr Gly Ala Ala Cys Cys Cys Cys Ala Thr Gly Thr Thr Thr Ala 
            660                 665                 670         


Cys Thr Thr Gly Cys Cys Cys Gly Gly Thr Thr Thr Ala Ala Thr Ala 
        675                 680                 685             


Ala Thr Thr Cys Thr Gly Cys Thr Thr Cys Thr Cys Thr Thr Cys Gly 
    690                 695                 700                 


Cys Gly Thr Cys Thr Gly Thr Gly Gly Cys Cys Cys Thr Gly Gly Thr 
705                 710                 715                 720 


Gly Gly Cys Thr Gly Cys Cys Ala Thr Cys Ala Thr Cys Thr Thr Thr 
                725                 730                 735     


Gly Gly Cys Gly Thr Thr Thr Gly Cys Thr Ala Thr Ala Gly Gly Ala 
            740                 745                 750         


Ala Ala Ala Ala Ala Gly Gly Gly Ala Ala Ala Gly Cys Ala Cys Thr 
        755                 760                 765             


Cys Ala Cys Ala Gly Cys Thr Ala Ala Thr Thr Thr Gly Thr Gly Gly 
    770                 775                 780                 


Cys Ala Cys Thr Gly Gly Ala Thr Cys Ala Ala Thr Gly Ala Gly Gly 
785                 790                 795                 800 


Cys Thr Thr Gly Thr Gly Gly Cys Cys Gly Cys Cys Thr Ala Ala Gly 
                805                 810                 815     


Thr Gly Gly Ala Gly Ala Thr Ala Ala Gly Gly Ala Gly Thr Cys Cys 
            820                 825                 830         


Thr Cys Ala Gly Gly Thr Gly Ala Cys Ala Gly Thr Thr Gly Thr Gly 
        835                 840                 845             


Thr Cys Ala Gly Thr Ala Cys Ala Cys Ala Cys Ala Cys Gly Gly Cys 
    850                 855                 860                 


Ala Ala Ala Cys Thr Thr Thr Gly Gly Thr Cys Ala Gly Cys Ala Gly 
865                 870                 875                 880 


Gly Gly Ala Gly Cys Ala Thr Gly Thr Gly Ala Ala Gly Gly Thr Gly 
                885                 890                 895     


Thr Cys Thr Thr Ala Cys Thr Gly Cys Thr Gly Ala Cys Thr Cys Thr 
            900                 905                 910         


Gly Gly Ala Gly Gly Ala Gly Ala Ala Gly Ala Cys Ala Thr Thr Thr 
        915                 920                 925             


Cys Cys Ala Gly Ala Ala Gly Ala Thr Ala Thr Gly Thr Gly Cys Thr 
    930                 935                 940                 


Ala Cys Cys Cys Ala Gly Ala Thr Cys Ala Ala Gly Gly Thr Gly Gly 
945                 950                 955                 960 


Thr Gly Thr Cys Thr Gly Thr Cys Ala Gly Gly Gly Cys Ala Cys Ala 
                965                 970                 975     


Thr Gly Thr Gly Thr Ala Gly Gly Ala Gly Gly Thr Gly Gly Thr Cys 
            980                 985                 990         


Cys Cys Thr Ala Cys Gly Cys Ala  Cys Ala Ala Gly Gly  Cys Gly Ala 
        995                 1000                 1005             


Ala Gly  Ala Thr Gly Cys Cys  Ala Gly Gly Ala Thr  Gly Cys Thr 
    1010                 1015                 1020             


Cys Thr  Cys Ala Thr Thr Gly  Gly Thr Cys Ala Gly  Cys Ala Ala 
    1025                 1030                 1035             


Gly Ala  Cys Cys Gly Ala Gly  Ala Thr Ala Gly Ala  Gly Gly Ala 
    1040                 1045                 1050             


Ala Gly  Ala Cys Ala Gly Cys  Thr Thr Cys Ala Gly  Ala Cys Ala 
    1055                 1060                 1065             


Gly Ala  Thr Gly Cys Cys Cys  Ala Cys Ala Gly Ala  Ala Gly Ala 
    1070                 1075                 1080             


Thr Gly  Ala Ala Thr Ala Cys  Ala Thr Gly Gly Ala  Cys Ala Gly 
    1085                 1090                 1095             


Gly Cys  Cys Cys Thr Cys Cys  Cys Ala Gly Cys Cys  Cys Ala Cys 
    1100                 1105                 1110             


Ala Gly  Ala Cys Cys Ala Gly  Thr Thr Ala Cys Thr  Gly Thr Thr 
    1115                 1120                 1125             


Cys Cys  Thr Cys Ala Cys Thr  Gly Ala Gly Cys Cys  Thr Gly Gly 
    1130                 1135                 1140             


Ala Ala  Gly Cys Ala Ala Ala  Thr Cys Cys Ala Cys  Ala Cys Cys 
    1145                 1150                 1155             


Thr Cys  Cys Thr Thr Thr Cys  Thr Cys Thr Gly Ala  Ala Cys Cys 
    1160                 1165                 1170             


Cys Cys  Thr Gly Gly Ala Gly  Gly Thr Gly Gly Gly  Gly Gly Ala 
    1175                 1180                 1185             


Gly Ala  Ala Thr Gly Ala Cys  Ala Gly Thr Thr Thr  Ala Ala Gly 
    1190                 1195                 1200             


Cys Cys  Ala Gly Thr Gly Cys  Thr Thr Cys Ala Cys  Gly Gly Gly 
    1205                 1210                 1215             


Gly Ala  Cys Ala Cys Ala Gly  Ala Gly Cys Ala Cys  Ala Gly Thr 
    1220                 1225                 1230             


Gly Gly  Gly Thr Thr Cys Ala  Gly Ala Ala Ala Gly  Cys Thr Gly 
    1235                 1240                 1245             


Cys Ala  Ala Cys Thr Gly Cys  Ala Cys Thr Gly Ala  Gly Cys Cys 
    1250                 1255                 1260             


Cys Cys  Thr Gly Thr Gly Cys  Ala Gly Gly Ala Cys  Thr Gly Ala 
    1265                 1270                 1275             


Thr Thr  Gly Gly Ala Cys Thr  Cys Cys Cys Ala Thr  Gly Thr Cys 
    1280                 1285                 1290             


Cys Thr  Cys Thr Gly Ala Ala  Ala Ala Cys Thr Ala  Cys Thr Thr 
    1295                 1300                 1305             


Gly Cys  Ala Ala Ala Ala Ala  Gly Ala Gly Gly Thr  Gly Gly Ala 
    1310                 1315                 1320             


Cys Ala  Gly Thr Gly Gly Cys  Cys Ala Thr Thr Gly  Cys Cys Cys 
    1325                 1330                 1335             


Gly Cys  Ala Cys Thr Gly Gly  Gly Cys Ala Gly Cys  Cys Ala Gly 
    1340                 1345                 1350             


Cys Cys  Cys Cys Ala Gly Cys  Cys Cys Cys Ala Ala  Cys Thr Gly 
    1355                 1360                 1365             


Gly Gly  Cys Ala Gly Ala Thr  Gly Thr Cys Thr Gly  Cys Ala Cys 
    1370                 1375                 1380             


Ala Gly  Gly Cys Thr Gly Cys  Cys Gly Gly Ala Ala  Cys Cys Cys 
    1385                 1390                 1395             


Thr Cys  Cys Thr Gly Gly Gly  Gly Ala Gly Gly Ala  Cys Thr Gly 
    1400                 1405                 1410             


Thr Gly  Ala Ala Cys Cys Cys  Cys Thr Cys Gly Thr  Gly Gly Gly 
    1415                 1420                 1425             


Thr Thr  Cys Cys Cys Cys Ala  Ala Ala Ala Cys Gly  Thr Gly Gly 
    1430                 1435                 1440             


Ala Cys  Cys Cys Thr Thr Gly  Cys Cys Cys Cys Ala  Gly Thr Gly 
    1445                 1450                 1455             


Cys Gly  Cys Cys Thr Ala Thr  Gly Gly Cys Ala Thr  Gly Gly Gly 
    1460                 1465                 1470             


Cys Cys  Thr Thr Cys Cys Cys  Cys Cys Thr Gly Ala  Ala Gly Ala 
    1475                 1480                 1485             


Ala Gly  Ala Ala Gly Cys Cys  Ala Gly Cys Ala Gly  Gly Ala Cys 
    1490                 1495                 1500             


Gly Gly  Ala Gly Gly Cys Cys  Ala Gly Ala Gly Ala  Cys Cys Ala 
    1505                 1510                 1515             


Gly Cys  Cys Cys Gly Ala Gly  Gly Ala Thr Gly Gly  Gly Gly Cys 
    1520                 1525                 1530             


Thr Gly  Ala Thr Gly Gly Gly  Ala Gly Gly Cys Thr  Cys Cys Cys 
    1535                 1540                 1545             


Ala Ala  Gly Cys Thr Cys Ala  Gly Cys Gly Ala Gly  Gly Gly Cys 
    1550                 1555                 1560             


Ala Gly  Gly Thr Gly Cys Cys  Gly Gly Gly Thr Cys  Thr Gly Gly 
    1565                 1570                 1575             


Ala Ala  Gly Cys Thr Cys Cys  Cys Cys Thr Gly Gly  Thr Gly Gly 
    1580                 1585                 1590             


Cys Cys  Ala Gly Thr Cys Cys  Cys Cys Thr Gly Cys  Ala Thr Cys 
    1595                 1600                 1605             


Thr Gly  Gly Ala Ala Ala Thr  Gly Thr Gly Ala Cys  Thr Gly Gly 
    1610                 1615                 1620             


Ala Ala  Ala Cys Ala Gly Thr  Ala Ala Cys Thr Cys  Cys Ala Cys 
    1625                 1630                 1635             


Gly Thr  Thr Cys Ala Thr Cys  Thr Cys Cys Ala Gly  Cys Gly Gly 
    1640                 1645                 1650             


Gly Cys  Ala Gly Gly Thr Gly  Ala Thr Gly Ala Ala  Cys Thr Thr 
    1655                 1660                 1665             


Cys Ala  Ala Gly Gly Gly Cys  Gly Ala Cys Ala Thr  Cys Ala Thr 
    1670                 1675                 1680             


Cys Gly  Thr Gly Gly Thr Cys  Thr Ala Cys Gly Thr  Cys Ala Gly 
    1685                 1690                 1695             


Cys Cys  Ala Gly Ala Cys Cys  Thr Cys Gly Cys Ala  Gly Gly Ala 
    1700                 1705                 1710             


Gly Gly  Gly Cys Gly Cys Gly  Gly Cys Gly Gly Cys  Gly Gly Cys 
    1715                 1720                 1725             


Thr Gly  Cys Gly Gly Ala Gly  Cys Cys Cys Ala Thr  Gly Gly Gly 
    1730                 1735                 1740             


Cys Cys  Gly Cys Cys Cys Gly  Gly Thr Gly Cys Ala  Gly Gly Ala 
    1745                 1750                 1755             


Gly Gly  Ala Gly Ala Cys Cys  Cys Thr Gly Gly Cys  Gly Cys Gly 
    1760                 1765                 1770             


Cys Cys  Gly Ala Gly Ala Cys  Thr Cys Cys Thr Thr  Cys Gly Cys 
    1775                 1780                 1785             


Gly Gly  Gly Gly Ala Ala Cys  Gly Gly Cys Cys Cys  Gly Cys Gly 
    1790                 1795                 1800             


Cys Thr  Thr Cys Cys Cys Gly  Gly Ala Cys Cys Cys  Gly Thr Gly 
    1805                 1810                 1815             


Cys Gly  Gly Cys Gly Gly Cys  Cys Cys Cys Gly Ala  Gly Gly Gly 
    1820                 1825                 1830             


Gly Cys  Thr Gly Cys Gly Gly  Gly Ala Gly Cys Cys  Gly Gly Ala 
    1835                 1840                 1845             


Gly Ala  Ala Gly Gly Cys Cys  Thr Cys Gly Ala Gly  Gly Cys Cys 
    1850                 1855                 1860             


Gly Gly  Thr Gly Cys Ala Gly  Gly Ala Gly Cys Ala  Ala Gly Gly 
    1865                 1870                 1875             


Cys Gly  Gly Gly Gly Cys Cys  Ala Ala Gly Gly Cys  Thr Thr Gly 
    1880                 1885                 1890             


Ala Gly  Cys Gly Cys Cys Cys  Cys Cys Cys Ala Thr  Gly Gly Cys 
    1895                 1900                 1905             


Thr Gly  Gly Gly Ala Gly Cys  Cys Cys Gly Ala Ala  Gly Cys Thr 
    1910                 1915                 1920             


Cys Gly  Gly Ala Gly Cys Cys  Ala Gly Gly Gly Cys  Thr Cys Gly 
    1925                 1930                 1935             


Cys Gly  Ala Gly Gly Gly Cys  Ala Gly Cys Ala Cys  Cys Gly Cys 
    1940                 1945                 1950             


Ala Gly  Cys Cys Thr Cys Thr  Gly Cys Cys Cys Cys  Ala Gly Cys 
    1955                 1960                 1965             


Cys Cys  Cys Gly Gly Cys Cys  Ala Cys Cys Cys Ala  Gly Gly Gly 
    1970                 1975                 1980             


Ala Thr  Cys Gly Ala Thr Cys  Gly Gly Thr Ala Cys  Ala Gly Thr 
    1985                 1990                 1995             


Cys Gly  Ala Gly Gly Ala Ala  Gly Ala Cys Cys Ala  Cys Cys Cys 
    2000                 2005                 2010             


Gly Gly  Cys Ala Thr Thr Cys  Thr Cys Thr Gly Cys  Cys Cys Ala 
    2015                 2020                 2025             


Cys Thr  Thr Thr Gly Cys Cys  Thr Thr Cys Cys Ala  Gly Gly Ala 
    2030                 2035                 2040             


Ala Ala  Thr Gly Gly Gly Cys  Thr Thr Thr Thr Cys  Ala Gly Gly 
    2045                 2050                 2055             


Ala Ala  Gly Thr Gly Ala Ala  Thr Thr Gly Ala Thr  Gly Ala Gly 
    2060                 2065                 2070             


Gly Ala  Cys Thr Gly Thr Cys  Cys Cys Cys Ala Thr  Gly Cys Cys 
    2075                 2080                 2085             


Cys Ala  Cys Gly Gly Ala Thr  Gly Cys Thr Cys Ala  Gly Cys Ala 
    2090                 2095                 2100             


Gly Cys  Cys Cys Gly Cys Cys  Gly Cys Ala Cys Thr  Gly Gly Gly 
    2105                 2110                 2115             


Gly Cys  Ala Gly Ala Thr Gly  Thr Cys Thr Cys Cys  Cys Cys Thr 
    2120                 2125                 2130             


Gly Cys  Cys Ala Cys Thr Cys  Cys Thr Cys Ala Ala  Ala Cys Thr 
    2135                 2140                 2145             


Cys Gly  Cys Ala Gly Cys Ala  Gly Thr Ala Ala Thr  Thr Thr Gly 
    2150                 2155                 2160             


Thr Gly  Gly Cys Ala Cys Thr  Ala Thr Gly Ala Cys  Ala Gly Cys 
    2165                 2170                 2175             


Thr Ala  Thr Thr Thr Thr Thr  Ala Thr Gly Ala Cys  Thr Ala Thr 
    2180                 2185                 2190             


Cys Cys  Thr Gly Thr Thr Cys  Thr Gly Thr Gly Gly  Gly Gly Gly 
    2195                 2200                 2205             


Gly Gly  Gly Gly Gly Gly Thr  Cys Thr Gly Thr Thr  Thr Thr Cys 
    2210                 2215                 2220             


Cys Cys  Cys Cys Cys Ala Thr  Ala Thr Thr Thr Gly  Thr Ala Thr 
    2225                 2230                 2235             


Thr Cys  Cys Thr Thr Thr Thr  Cys Ala Thr Ala Ala  Cys Thr Thr 
    2240                 2245                 2250             


Thr Thr  Cys Thr Thr Gly Ala  Thr Ala Thr Cys Thr  Thr Thr Cys 
    2255                 2260                 2265             


Cys Thr  Cys Cys Cys Thr Cys  Thr Thr Thr Thr Thr  Thr Ala Ala 
    2270                 2275                 2280             


Thr Gly  Thr Ala Ala Ala Gly  Gly Thr Thr Thr Thr  Cys Thr Cys 
    2285                 2290                 2295             


Ala Ala  Ala Ala Ala Thr Thr  Cys Thr Cys Cys Thr  Ala Ala Ala 
    2300                 2305                 2310             


Gly Gly  Thr Gly Ala Gly Gly  Gly Thr Cys Thr Cys  Thr Thr Thr 
    2315                 2320                 2325             


Cys Thr  Thr Thr Thr Cys Thr  Cys Thr Thr Thr Thr  Cys Cys Thr 
    2330                 2335                 2340             


Thr Thr  Thr Thr Thr Thr Thr  Thr Thr Cys Thr Thr  Thr Thr Thr 
    2345                 2350                 2355             


Thr Thr  Gly Gly Cys Ala Ala  Cys Cys Thr Gly Gly  Cys Thr Cys 
    2360                 2365                 2370             


Thr Gly  Gly Cys Cys Cys Ala  Gly Gly Cys Thr Ala  Gly Ala Gly 
    2375                 2380                 2385             


Thr Gly  Cys Ala Gly Thr Gly  Gly Thr Gly Cys Gly  Ala Thr Thr 
    2390                 2395                 2400             


Ala Thr  Ala Gly Cys Cys Cys  Gly Gly Thr Gly Cys  Ala Gly Cys 
    2405                 2410                 2415             


Cys Thr  Cys Thr Ala Ala Cys  Thr Cys Cys Thr Gly  Gly Gly Cys 
    2420                 2425                 2430             


Thr Cys  Ala Ala Gly Cys Ala  Ala Thr Cys Cys Ala  Ala Gly Thr 
    2435                 2440                 2445             


Gly Ala  Thr Cys Cys Thr Cys  Cys Cys Ala Cys Cys  Thr Cys Ala 
    2450                 2455                 2460             


Ala Cys  Cys Thr Thr Cys Gly  Gly Ala Gly Thr Ala  Gly Cys Thr 
    2465                 2470                 2475             


Gly Gly  Gly Ala Thr Cys Ala  Cys Ala Gly Cys Thr  Gly Cys Ala 
    2480                 2485                 2490             


Gly Gly  Cys Cys Ala Cys Gly  Cys Cys Cys Ala Gly  Cys Thr Thr 
    2495                 2500                 2505             


Cys Cys  Thr Cys Cys Cys Cys  Cys Cys Gly Ala Cys  Thr Cys Cys 
    2510                 2515                 2520             


Cys Cys  Cys Cys Cys Cys Ala  Gly Ala Gly Ala Cys  Ala Cys Gly 
    2525                 2530                 2535             


Gly Thr  Cys Cys Cys Ala Cys  Cys Ala Thr Gly Thr  Thr Ala Cys 
    2540                 2545                 2550             


Cys Cys  Ala Gly Cys Cys Thr  Gly Gly Thr Cys Thr  Cys Ala Ala 
    2555                 2560                 2565             


Ala Cys  Thr Cys Cys Cys Cys  Ala Gly Cys Thr Ala  Ala Ala Gly 
    2570                 2575                 2580             


Cys Ala  Gly Thr Cys Cys Thr  Cys Cys Ala Gly Cys  Cys Thr Cys 
    2585                 2590                 2595             


Gly Gly  Cys Cys Thr Cys Cys  Cys Ala Ala Ala Gly  Thr Ala Cys 
    2600                 2605                 2610             


Thr Gly  Gly Gly Ala Thr Thr  Ala Cys Ala Gly Gly  Cys Gly Thr 
    2615                 2620                 2625             


Gly Ala  Gly Cys Cys Cys Cys  Cys Ala Cys Gly Cys  Thr Gly Gly 
    2630                 2635                 2640             


Cys Cys  Thr Gly Cys Thr Thr  Thr Ala Cys Gly Thr  Ala Thr Thr 
    2645                 2650                 2655             


Thr Thr  Cys Thr Thr Thr Thr  Gly Thr Gly Cys Cys  Cys Cys Thr 
    2660                 2665                 2670             


Gly Cys  Thr Cys Ala Cys Ala  Gly Thr Gly Thr Thr  Thr Thr Ala 
    2675                 2680                 2685             


Gly Ala  Gly Ala Thr Gly Gly  Cys Thr Thr Thr Cys  Cys Cys Ala 
    2690                 2695                 2700             


Gly Thr  Gly Thr Gly Thr Gly  Thr Thr Cys Ala Thr  Thr Gly Thr 
    2705                 2710                 2715             


Ala Ala  Ala Cys Ala Cys Thr  Thr Thr Thr Gly Gly  Gly Ala Ala 
    2720                 2725                 2730             


Ala Gly  Gly Gly Cys Thr Ala  Ala Ala Cys Ala Thr  Gly Thr Gly 
    2735                 2740                 2745             


Ala Gly  Gly Cys Cys Thr Gly  Gly Ala Gly Ala Thr  Ala Gly Thr 
    2750                 2755                 2760             


Thr Gly  Cys Thr Ala Ala Gly  Thr Thr Gly Cys Thr  Ala Gly Gly 
    2765                 2770                 2775             


Ala Ala  Cys Ala Thr Gly Thr  Gly Gly Thr Gly Gly  Gly Ala Cys 
    2780                 2785                 2790             


Thr Thr  Thr Cys Ala Thr Ala  Thr Thr Cys Thr Gly  Ala Ala Ala 
    2795                 2800                 2805             


Ala Ala  Thr Gly Thr Thr Cys  Thr Ala Thr Ala Thr  Thr Cys Thr 
    2810                 2815                 2820             


Cys Ala  Thr Thr Thr Thr Thr  Cys Thr Ala Ala Ala  Ala Gly Ala 
    2825                 2830                 2835             


Ala Ala  Gly Ala Ala Ala Ala  Ala Ala Gly Gly Ala  Ala Ala Cys 
    2840                 2845                 2850             


Cys Cys  Gly Ala Thr Thr Thr  Ala Thr Thr Thr Cys  Thr Cys Cys 
    2855                 2860                 2865             


Thr Gly  Ala Ala Thr Cys Thr  Thr Thr Thr Thr Ala  Ala Gly Thr 
    2870                 2875                 2880             


Thr Thr  Gly Thr Gly Thr Cys  Gly Thr Thr Cys Cys  Thr Thr Ala 
    2885                 2890                 2895             


Ala Gly  Cys Ala Gly Ala Ala  Cys Thr Ala Ala Gly  Cys Thr Cys 
    2900                 2905                 2910             


Ala Gly  Thr Ala Thr Gly Thr  Gly Ala Cys Cys Thr  Thr Ala Cys 
    2915                 2920                 2925             


Cys Cys  Gly Cys Thr Ala Gly  Gly Thr Gly Gly Thr  Thr Ala Ala 
    2930                 2935                 2940             


Thr Thr  Thr Ala Thr Cys Cys  Ala Thr Gly Cys Thr  Gly Gly Cys 
    2945                 2950                 2955             


Ala Gly  Ala Gly Gly Cys Ala  Cys Thr Cys Ala Gly  Gly Thr Ala 
    2960                 2965                 2970             


Cys Thr  Thr Gly Gly Thr Ala  Ala Gly Cys Ala Ala  Ala Thr Thr 
    2975                 2980                 2985             


Thr Cys  Thr Ala Ala Ala Ala  Cys Thr Cys Cys Ala  Ala Gly Thr 
    2990                 2995                 3000             


Thr Gly  Cys Thr Gly Cys Ala  Gly Cys Thr Thr Gly  Gly Cys Ala 
    3005                 3010                 3015             


Thr Thr  Cys Thr Thr Cys Thr  Thr Ala Thr Thr Cys  Thr Ala Gly 
    3020                 3025                 3030             


Ala Gly  Gly Thr Cys Thr Cys  Thr Cys Thr Gly Gly  Ala Ala Ala 
    3035                 3040                 3045             


Ala Gly  Ala Thr Gly Gly Ala  Gly Ala Ala Ala Ala  Thr Gly Ala 
    3050                 3055                 3060             


Ala Cys  Ala Gly Gly Ala Cys  Ala Thr Gly Gly Gly  Gly Cys Thr 
    3065                 3070                 3075             


Cys Cys  Thr Gly Gly Ala Ala  Ala Gly Ala Ala Ala  Gly Gly Gly 
    3080                 3085                 3090             


Cys Cys  Cys Gly Gly Gly Ala  Ala Gly Thr Thr Cys  Ala Ala Gly 
    3095                 3100                 3105             


Gly Ala  Ala Gly Ala Ala Thr  Ala Ala Ala Gly Thr  Thr Gly Ala 
    3110                 3115                 3120             


Ala Ala  Thr Thr Thr Thr Ala  Ala Thr Thr Thr Gly  Cys Ala Thr 
    3125                 3130                 3135             


Thr Thr  Thr Thr Thr Thr Thr  Gly Thr Cys Thr Ala  Gly Ala Thr 
    3140                 3145                 3150             


Ala Ala  Gly Ala Ala Thr Ala  Gly Cys Gly Thr Gly  Ala Ala Thr 
    3155                 3160                 3165             


Ala Gly  Ala Thr Cys Cys Thr  Cys Thr Thr Thr Thr  Ala Thr Thr 
    3170                 3175                 3180             


Cys Gly  Thr Ala Ala Ala Thr  Ala Ala Thr Cys Gly  Thr Gly Cys 
    3185                 3190                 3195             


Ala Thr  Cys Thr Gly Thr Gly  Gly Gly Thr Thr Ala  Gly Cys Cys 
    3200                 3205                 3210             


Thr Thr  Gly Thr Ala Gly Ala  Ala Gly Thr Gly Gly  Ala Ala Ala 
    3215                 3220                 3225             


Ala Cys  Ala Thr Thr Cys Cys  Ala Thr Thr Thr Thr  Cys Cys Ala 
    3230                 3235                 3240             


Ala Thr  Gly Cys Ala Thr Thr  Thr Ala Ala Ala Thr  Gly Thr Ala 
    3245                 3250                 3255             


Ala Ala  Gly Cys Cys Ala Ala  Ala Thr Cys Thr Gly  Cys Ala Thr 
    3260                 3265                 3270             


Gly Thr  Thr Gly Thr Gly Ala  Ala Thr Thr Thr Ala  Ala Gly Ala 
    3275                 3280                 3285             


Ala Ala  Ala Cys Thr Thr Ala  Thr Thr Ala Thr Cys  Cys Thr Ala 
    3290                 3295                 3300             


Ala Ala  Gly Gly Thr Gly Cys  Cys Thr Thr Thr Cys  Thr Cys Thr 
    3305                 3310                 3315             


Thr Gly  Gly Cys Ala Thr Cys  Ala Thr Cys Cys Cys  Gly Cys Thr 
    3320                 3325                 3330             


Thr Gly  Thr Gly Ala Gly Ala  Ala Gly Cys Cys Thr  Ala Gly Ala 
    3335                 3340                 3345             


Gly Gly  Ala Cys Gly Cys Thr  Cys Cys Ala Gly Gly  Thr Gly Gly 
    3350                 3355                 3360             


Ala Ala  Gly Gly Ala Ala Ala  Thr Cys Cys Cys Cys  Thr Gly Gly 
    3365                 3370                 3375             


Gly Thr  Gly Gly Thr Thr Thr  Thr Ala Thr Cys Thr  Thr Thr Thr 
    3380                 3385                 3390             


Gly Thr  Thr Ala Cys Cys Cys  Ala Gly Thr Gly Ala  Gly Cys Ala 
    3395                 3400                 3405             


Cys Thr  Gly Gly Thr Thr Cys  Cys Cys Cys Gly Cys  Ala Ala Ala 
    3410                 3415                 3420             


Thr Ala  Cys Thr Gly Gly Gly  Gly Ala Ala Ala Ala  Gly Cys Ala 
    3425                 3430                 3435             


Ala Ala  Ala Ala Thr Ala Cys  Ala Cys Ala Ala Gly  Cys Ala Ala 
    3440                 3445                 3450             


Gly Thr  Thr Ala Ala Ala Ala  Thr Thr Ala Ala Thr  Thr Thr Thr 
    3455                 3460                 3465             


Gly Cys  Ala Cys Ala Thr Cys  Thr Gly Gly Gly Ala  Gly Gly Thr 
    3470                 3475                 3480             


Thr Ala  Thr Ala Ala Ala Ala  Gly Ala Ala Ala Gly  Cys Ala Cys 
    3485                 3490                 3495             


Thr Ala  Ala Thr Ala Gly Thr  Ala Gly Thr Cys Ala  Cys Thr Gly 
    3500                 3505                 3510             


Cys Cys  Cys Ala Gly Ala Cys  Thr Thr Thr Ala Cys  Thr Gly Gly 
    3515                 3520                 3525             


Cys Cys  Ala Cys Ala Ala Ala  Thr Gly Cys Cys Cys  Ala Gly Cys 
    3530                 3535                 3540             


Thr Gly  Ala Ala Gly Ala Gly  Cys Ala Thr Gly Ala  Cys Thr Gly 
    3545                 3550                 3555             


Thr Gly  Gly Ala Thr Cys Ala  Cys Thr Gly Gly Thr  Thr Thr Thr 
    3560                 3565                 3570             


Thr Cys  Cys Cys Thr Cys Cys  Thr Gly Cys Thr Gly  Gly Ala Ala 
    3575                 3580                 3585             


Ala Thr  Gly Cys Thr Gly Gly  Gly Gly Thr Gly Gly  Thr Ala Gly 
    3590                 3595                 3600             


Cys Gly  Gly Thr Cys Gly Ala  Thr Thr Ala Gly Gly  Ala Thr Thr 
    3605                 3610                 3615             


Thr Thr  Cys Ala Gly Thr Gly  Gly Ala Gly Ala Ala  Gly Cys Ala 
    3620                 3625                 3630             


Cys Ala  Gly Gly Ala Cys Ala  Gly Thr Thr Cys Thr  Gly Thr Ala 
    3635                 3640                 3645             


Ala Thr  Thr Thr Ala Thr Gly  Gly Gly Ala Cys Thr  Cys Cys Thr 
    3650                 3655                 3660             


Thr Ala  Gly Cys Cys Ala Ala  Cys Ala Thr Ala Ala  Ala Gly Ala 
    3665                 3670                 3675             


Ala Cys  Thr Gly Cys Ala Gly  Gly Ala Ala Ala Thr  Ala Ala Cys 
    3680                 3685                 3690             


Thr Gly  Cys Ala Cys Ala Gly  Cys Cys Ala Gly Gly  Ala Gly Gly 
    3695                 3700                 3705             


Ala Thr  Cys Cys Gly Thr Thr  Gly Gly Thr Gly Gly  Gly Ala Ala 
    3710                 3715                 3720             


Thr Thr  Thr Ala Cys Cys Gly  Thr Cys Ala Thr Thr  Cys Cys Thr 
    3725                 3730                 3735             


Gly Cys  Cys Cys Thr Thr Thr  Thr Ala Thr Thr Thr  Ala Ala Cys 
    3740                 3745                 3750             


Ala Thr  Cys Ala Thr Cys Cys  Ala Cys Ala Gly Ala  Gly Ala Gly 
    3755                 3760                 3765             


Ala Thr  Gly Thr Thr Ala Thr  Ala Cys Ala Ala Ala  Thr Gly Gly 
    3770                 3775                 3780             


Ala Gly  Gly Ala Ala Ala Cys  Cys Ala Thr Thr Ala  Thr Ala Cys 
    3785                 3790                 3795             


Cys Thr  Thr Thr Thr Gly Ala  Thr Ala Thr Gly Gly  Ala Ala Thr 
    3800                 3805                 3810             


Ala Thr  Ala Thr Thr Ala Cys  Ala Gly Ala Gly Thr  Thr Ala Cys 
    3815                 3820                 3825             


Ala Gly  Thr Thr Cys Ala Cys  Ala Ala Ala Gly Thr  Ala Gly Ala 
    3830                 3835                 3840             


Ala Thr  Gly Cys Thr Gly Ala  Gly Cys Thr Gly Ala  Ala Ala Ala 
    3845                 3850                 3855             


Cys Cys  Cys Gly Ala Gly Thr  Thr Thr Cys Thr Gly  Cys Thr Gly 
    3860                 3865                 3870             


Thr Gly  Ala Cys Thr Gly Thr  Cys Ala Thr Cys Thr  Cys Ala Cys 
    3875                 3880                 3885             


Thr Gly  Ala Gly Cys Ala Cys  Thr Thr Cys Gly Cys  Thr Thr Thr 
    3890                 3895                 3900             


Thr Cys  Thr Thr Thr Gly Cys  Thr Thr Thr Thr Ala  Thr Thr Thr 
    3905                 3910                 3915             


Thr Thr  Thr Cys Cys Thr Thr  Cys Thr Ala Thr Ala  Ala Ala Ala 
    3920                 3925                 3930             


Ala Gly  Gly Cys Ala Ala Thr  Ala Ala Thr Gly Ala  Thr Ala Ala 
    3935                 3940                 3945             


Thr Thr  Thr Ala Thr Ala Ala  Thr Ala Gly Thr Thr  Thr Cys Cys 
    3950                 3955                 3960             


Cys Thr  Ala Cys Cys Cys Ala  Gly Ala Gly Ala Thr  Ala Thr Thr 
    3965                 3970                 3975             


Ala Gly  Ala Ala Gly Thr Ala  Thr Gly Cys Thr Ala  Cys Ala Gly 
    3980                 3985                 3990             


Thr Gly  Ala Ala Thr Gly Thr  Thr Ala Ala Ala Gly  Thr Ala Cys 
    3995                 4000                 4005             


Cys Thr  Thr Gly Ala Gly Ala  Thr Cys Cys Thr Thr  Ala Ala Ala 
    4010                 4015                 4020             


Thr Cys  Ala Ala Ala Gly Gly  Thr Gly Cys Thr Ala  Thr Ala Thr 
    4025                 4030                 4035             


Ala Cys  Ala Thr Ala Ala Gly  Thr Ala Ala Gly Ala  Cys Thr Cys 
    4040                 4045                 4050             


Thr Ala  Cys Thr Thr Thr Cys  Ala Gly Ala Ala Ala  Ala Ala Gly 
    4055                 4060                 4065             


Gly Thr  Ala Ala Thr Ala Thr  Thr Ala Thr Thr Thr  Cys Cys Thr 
    4070                 4075                 4080             


Gly Cys  Ala Cys Thr Gly Ala  Thr Cys Cys Cys Thr  Ala Cys Thr 
    4085                 4090                 4095             


Ala Ala  Thr Thr Cys Thr Ala  Thr Ala Thr Thr Gly  Ala Thr Cys 
    4100                 4105                 4110             


Cys Ala  Ala Ala Gly Gly Cys  Ala Ala Cys Thr Cys  Ala Ala Thr 
    4115                 4120                 4125             


Gly Cys  Thr Ala Ala Ala Ala  Ala Ala Thr Gly Thr  Ala Thr Ala 
    4130                 4135                 4140             


Gly Ala  Ala Ala Ala Thr Ala  Thr Ala Ala Gly Thr  Cys Thr Gly 
    4145                 4150                 4155             


Thr Gly  Thr Cys Thr Gly Thr  Gly Thr Ala Cys Thr  Gly Thr Ala 
    4160                 4165                 4170             


Gly Ala  Gly Ala Thr Gly Thr  Ala Thr Gly Thr Gly  Ala Cys Ala 
    4175                 4180                 4185             


Ala Gly  Thr Gly Thr Ala Ala  Ala Cys Ala Ala Ala  Ala Thr Gly 
    4190                 4195                 4200             


Ala Ala  Cys Thr Gly Ala Ala  Gly Cys Ala Gly Thr  Ala Ala Thr 
    4205                 4210                 4215             


Gly Ala  Ala Cys Ala Gly Thr  Thr Ala Thr Thr Ala  Gly Gly Gly 
    4220                 4225                 4230             


Gly Gly  Ala Ala Cys Ala Thr  Gly Ala Thr Ala Ala  Ala Gly Ala 
    4235                 4240                 4245             


Gly Ala  Thr Thr Ala Thr Ala  Thr Thr Ala Ala Gly  Cys Thr Thr 
    4250                 4255                 4260             


Ala Thr  Gly Thr Thr Thr Cys  Ala Cys Cys Ala Thr  Ala Ala Ala 
    4265                 4270                 4275             


Ala Thr  Cys Cys Thr Thr Thr  Thr Thr Ala Thr Gly  Gly Cys Thr 
    4280                 4285                 4290             


Thr Ala  Cys Thr Ala Ala Ala  Ala Cys Cys Gly Ala  Gly Cys Thr 
    4295                 4300                 4305             


Cys Ala  Cys Thr Gly Thr Ala  Ala Ala Ala Thr Cys  Ala Thr Gly 
    4310                 4315                 4320             


Ala Thr  Cys Cys Ala Ala Cys  Thr Thr Ala Thr Thr  Gly Cys Thr 
    4325                 4330                 4335             


Ala Ala  Thr Cys Thr Thr Thr  Ala Thr Gly Ala Thr  Ala Thr Gly 
    4340                 4345                 4350             


Cys Thr  Thr Ala Thr Thr Cys  Cys Thr Ala Ala Thr  Cys Thr Thr 
    4355                 4360                 4365             


Thr Ala  Thr Gly Gly Thr Ala  Thr Gly Gly Thr Gly  Thr Cys Ala 
    4370                 4375                 4380             


Ala Cys  Cys Gly Thr Thr Cys  Ala Thr Thr Thr Gly  Thr Ala Thr 
    4385                 4390                 4395             


Cys Thr  Thr Ala Thr Thr Gly  Cys Thr Cys Ala Thr  Thr Cys Cys 
    4400                 4405                 4410             


Cys Thr  Gly Gly Ala Cys Cys  Ala Cys Ala Gly Ala  Cys Thr Ala 
    4415                 4420                 4425             


Gly Gly  Gly Ala Cys Ala Gly  Ala Ala Ala Ala Thr  Ala Cys Thr 
    4430                 4435                 4440             


Thr Gly  Cys Thr Thr Thr Ala  Ala Thr Ala Ala Thr  Ala Thr Ala 
    4445                 4450                 4455             


Thr Ala  Thr Gly Cys Thr Gly  Thr Thr Gly Ala Thr  Thr Thr Cys 
    4460                 4465                 4470             


Ala Cys  Ala Ala Ala Ala Ala  Thr Thr Thr Ala Thr  Thr Ala Ala 
    4475                 4480                 4485             


Ala Ala  Thr Ala Cys Ala Gly  Cys Cys Thr Gly Gly  Gly Thr Ala 
    4490                 4495                 4500             


Cys Cys  Cys Ala Gly Thr Gly  Ala Ala Ala Gly Ala  Gly Cys Thr 
    4505                 4510                 4515             


Gly Ala  Ala Ala Thr Gly Gly  Ala Ala Ala Thr Gly  Gly Ala Gly 
    4520                 4525                 4530             


Thr Ala  Thr Cys Ala Thr Gly  Thr Thr Thr Cys Cys  Thr Ala Cys 
    4535                 4540                 4545             


Thr Cys  Ala Cys Ala Thr Thr  Thr Thr Ala Cys Thr  Cys Ala Gly 
    4550                 4555                 4560             


Cys Thr  Gly Thr Cys Gly Gly  Ala Ala Gly Gly Ala  Ala Gly Ala 
    4565                 4570                 4575             


Ala Thr  Gly Ala Ala Thr Thr  Thr Cys Thr Cys Ala  Ala Gly Ala 
    4580                 4585                 4590             


Gly Cys  Ala Gly Thr Thr Thr  Gly Ala Ala Thr Gly  Thr Gly Thr 
    4595                 4600                 4605             


Thr Ala  Gly Ala Thr Cys Ala  Gly Ala Ala Cys Cys  Thr Thr Cys 
    4610                 4615                 4620             


Ala Thr  Gly Thr Gly Gly Thr  Gly Gly Gly Gly Ala  Ala Ala Ala 
    4625                 4630                 4635             


Thr Gly  Gly Gly Ala Thr Thr  Ala Thr Thr Thr Cys  Ala Gly Thr 
    4640                 4645                 4650             


Gly Thr  Ala Ala Cys Ala Ala  Ala Cys Cys Ala Cys  Cys Cys Ala 
    4655                 4660                 4665             


Ala Ala  Gly Ala Cys Thr Thr  Ala Gly Thr Gly Gly  Cys Thr Thr 
    4670                 4675                 4680             


Ala Ala  Ala Ala Thr Ala Gly  Thr Cys Ala Cys Cys  Ala Thr Thr 
    4685                 4690                 4695             


Gly Gly  Cys Cys Ala Gly Gly  Cys Ala Cys Ala Gly  Cys Gly Gly 
    4700                 4705                 4710             


Thr Thr  Cys Ala Thr Gly Cys  Cys Thr Cys Cys Cys  Ala Gly Thr 
    4715                 4720                 4725             


Gly Cys  Thr Thr Thr Gly Gly  Gly Ala Gly Gly Cys  Cys Ala Ala 
    4730                 4735                 4740             


Gly Gly  Cys Ala Gly Gly Ala  Gly Gly Ala Thr Cys  Ala Cys Thr 
    4745                 4750                 4755             


Thr Gly  Ala Gly Gly Ala Cys  Ala Gly Thr Ala Gly  Thr Thr Ala 
    4760                 4765                 4770             


Gly Ala  Gly Ala Thr Cys Ala  Ala Ala Cys Thr Gly  Gly Gly Cys 
    4775                 4780                 4785             


Ala Ala  Thr Gly Gly Ala Gly  Thr Gly Ala Gly Ala  Cys Cys Thr 
    4790                 4795                 4800             


Cys Gly  Thr Cys Thr Cys Thr  Ala Cys Ala Ala Ala  Ala Ala Ala 
    4805                 4810                 4815             


Thr Ala  Cys Ala Ala Ala Ala  Cys Thr Thr Ala Thr  Cys Thr Gly 
    4820                 4825                 4830             


Gly Gly  Cys Ala Cys Gly Gly  Thr Gly Gly Thr Gly  Thr Gly Cys 
    4835                 4840                 4845             


Ala Cys  Cys Thr Gly Cys Ala  Gly Thr Cys Cys Thr  Gly Gly Cys 
    4850                 4855                 4860             


Thr Ala  Cys Thr Cys Ala Gly  Gly Ala Gly Gly Cys  Thr Gly Ala 
    4865                 4870                 4875             


Gly Gly  Cys Ala Gly Gly Ala  Gly Gly Ala Thr Gly  Cys Thr Thr 
    4880                 4885                 4890             


Gly Ala  Gly Thr Cys Cys Ala  Gly Gly Ala Gly Thr  Thr Cys Ala 
    4895                 4900                 4905             


Ala Gly  Gly Thr Thr Ala Cys  Thr Gly Thr Gly Ala  Gly Cys Thr 
    4910                 4915                 4920             


Thr Thr  Gly Ala Thr Thr Gly  Gly Gly Thr Cys Ala  Gly Thr Gly 
    4925                 4930                 4935             


Cys Ala  Cys Thr Cys Cys Ala  Gly Thr Gly Thr Ala  Ala Ala Ala 
    4940                 4945                 4950             


Ala Ala  Ala Cys Ala Ala Ala  Ala Ala Thr Ala Ala  Ala Ala Ala 
    4955                 4960                 4965             


Cys Cys  Ala Cys Cys Ala Cys  Thr Thr Ala Thr Thr  Thr Ala Gly 
    4970                 4975                 4980             


Cys Thr  Cys Cys Cys Ala Ala  Thr Thr Cys Thr Ala  Thr Gly Gly 
    4985                 4990                 4995             


Gly Thr  Thr Gly Gly Ala Thr  Cys Ala Gly Cys Thr  Thr Gly Gly 
    5000                 5005                 5010             


Gly Thr  Gly Gly Thr Thr Cys  Thr Thr Cys Ala Gly  Gly Cys Cys 
    5015                 5020                 5025             


Thr Gly  Gly Thr Cys Cys Cys  Thr Cys Cys Thr Gly  Gly Cys Cys 
    5030                 5035                 5040             


Thr Gly  Gly Thr Thr Thr Gly  Cys Thr Thr Ala Cys  Cys Cys Ala 
    5045                 5050                 5055             


Thr Thr  Thr Ala Cys Ala Ala  Thr Gly Ala Cys Cys  Cys Gly Gly 
    5060                 5065                 5070             


Cys Thr  Ala Gly Thr Thr Gly  Gly Cys Cys Gly Gly  Gly Cys Cys 
    5075                 5080                 5085             


Ala Gly  Gly Cys Thr Gly Thr  Gly Thr Gly Cys Thr  Cys Thr Cys 
    5090                 5095                 5100             


Cys Ala  Cys Cys Thr Gly Thr  Cys Thr Cys Cys Cys  Ala Thr Cys 
    5105                 5110                 5115             


Cys Thr  Thr Cys Cys Ala Gly  Cys Cys Ala Cys Cys  Thr Ala Gly 
    5120                 5125                 5130             


Cys Thr  Gly Gly Gly Cys Ala  Thr Gly Cys Thr Cys  Thr Cys Ala 
    5135                 5140                 5145             


Thr Gly  Gly Thr Gly Gly Thr  Gly Thr Cys Gly Ala  Gly Cys Cys 
    5150                 5155                 5160             


Thr Gly  Ala Gly Ala Ala Cys  Ala Ala Gly Cys Ala  Gly Ala Ala 
    5165                 5170                 5175             


Ala Cys  Cys Thr Gly Cys Cys  Ala Gly Gly Cys Thr  Thr Cys Thr 
    5180                 5185                 5190             


Thr Gly  Ala Gly Gly Cys Cys  Thr Ala Gly Gly Cys  Thr Cys Thr 
    5195                 5200                 5205             


Ala Ala  Cys Thr Gly Gly Cys  Ala Thr Gly Cys Thr  Gly Thr Cys 
    5210                 5215                 5220             


Ala Cys  Thr Thr Cys Thr Gly  Cys Cys Ala Cys Ala  Thr Thr Cys 
    5225                 5230                 5235             


Thr Gly  Thr Gly Gly Gly Cys  Cys Ala Ala Ala Gly  Cys Ala Gly 
    5240                 5245                 5250             


Gly Thr  Cys Ala Cys Ala Ala  Ala Gly Gly Cys Ala  Gly Cys Cys 
    5255                 5260                 5265             


Cys Ala  Gly Ala Thr Cys Cys  Ala Ala Gly Gly Gly  Ala Thr Gly 
    5270                 5275                 5280             


Gly Gly  Gly Gly Ala Gly Cys  Ala Gly Cys Ala Thr  Ala Thr Cys 
    5285                 5290                 5295             


Cys Cys  Cys Cys Cys Ala Thr  Gly Gly Gly Ala Ala  Gly Ala Gly 
    5300                 5305                 5310             


Thr Thr  Gly Cys Gly Gly Ala  Ala Thr Gly Ala Gly  Ala Gly Gly 
    5315                 5320                 5325             


Gly Thr  Ala Gly Gly Gly Gly  Gly Thr Gly Gly Ala  Cys Ala Cys 
    5330                 5335                 5340             


Ala Cys  Ala Gly Ala Gly Gly  Gly Gly Ala Ala Gly  Ala Thr Gly 
    5345                 5350                 5355             


Gly Cys  Cys Cys Cys Cys Thr  Thr Gly Cys Cys Ala  Thr Cys Thr 
    5360                 5365                 5370             


Gly Thr  Cys Cys Ala Cys Cys  Ala Cys Ala Gly Gly  Gly Cys Ala 
    5375                 5380                 5385             


Cys Thr  Gly Cys Gly Thr Gly  Gly Ala Gly Thr Ala  Ala Ala Ala 
    5390                 5395                 5400             


Thr Gly  Cys Thr Gly Cys Ala  Gly Ala Gly Ala Ala  Gly Ala Gly 
    5405                 5410                 5415             


Thr Gly  Cys Ala Thr Thr Cys  Thr Gly Gly Gly Ala  Ala Ala Ala 
    5420                 5425                 5430             


Ala Ala  Ala Gly Ala Gly Gly  Ala Ala Cys Ala Thr  Ala Thr Cys 
    5435                 5440                 5445             


Cys Cys  Ala Gly Cys Cys Cys  Cys Thr Ala Ala Cys  Cys Ala Gly 
    5450                 5455                 5460             


Thr Gly  Ala Gly Thr Ala Gly  Cys Thr Cys Cys Thr  Thr Cys Thr 
    5465                 5470                 5475             


Cys Thr  Gly Gly Thr Gly Ala  Thr Thr Gly Ala Ala  Thr Thr Cys 
    5480                 5485                 5490             


Cys Cys  Thr Thr Ala Ala Thr  Gly Cys Ala Cys Ala  Gly Cys Ala 
    5495                 5500                 5505             


Cys Thr  Ala Thr Ala Gly Ala  Thr Thr Cys Cys Cys  Ala Cys Ala 
    5510                 5515                 5520             


Ala Thr  Gly Ala Ala Ala Gly  Gly Gly Ala Cys Ala  Cys Cys Cys 
    5525                 5530                 5535             


Ala Cys  Gly Thr Thr Cys Ala  Thr Ala Thr Thr Thr  Ala Ala Gly 
    5540                 5545                 5550             


Thr Gly  Cys Thr Gly Thr Gly  Thr Cys Ala Ala Ala  Ala Thr Thr 
    5555                 5560                 5565             


Cys Thr  Thr Thr Cys Cys Ala  Gly Ala Gly Cys Cys  Ala Ala Ala 
    5570                 5575                 5580             


Thr Ala  Thr Ala Gly Gly Thr  Gly Ala Thr Thr Thr  Gly Gly Gly 
    5585                 5590                 5595             


Ala Ala  Thr Thr Gly Ala Gly  Cys Cys Thr Ala Cys  Thr Gly Thr 
    5600                 5605                 5610             


Ala Cys  Thr Gly Cys Thr Thr  Cys Cys Ala Cys Ala  Thr Thr Cys 
    5615                 5620                 5625             


Cys Thr  Thr Thr Gly Gly Cys  Ala Cys Ala Gly Ala  Ala Ala Ala 
    5630                 5635                 5640             


Cys Thr  Gly Ala Ala Ala Ala  Gly Thr Cys Ala Cys  Ala Ala Cys 
    5645                 5650                 5655             


Thr Thr  Cys Thr Ala Ala Ala  Ala Thr Cys Ala Ala  Gly Ala Ala 
    5660                 5665                 5670             


Ala Ala  Cys Thr Gly Gly Thr  Gly Ala Gly Ala Thr  Ala Cys Cys 
    5675                 5680                 5685             


Thr Thr  Gly Gly Gly Gly Thr  Ala Gly Ala Gly Ala  Ala Ala Cys 
    5690                 5695                 5700             


Cys Thr  Gly Cys Ala Thr Ala  Thr Ala Ala Ala Cys  Ala Gly Ala 
    5705                 5710                 5715             


Thr Ala  Ala Ala Ala Gly Ala  Thr Cys Gly Ala Gly  Thr Gly Thr 
    5720                 5725                 5730             


Thr Cys  Ala Cys Cys Cys Thr  Thr Cys Ala Cys Cys  Thr Cys Ala 
    5735                 5740                 5745             


Gly Cys  Thr Cys Ala Ala Cys  Ala Ala Ala Cys Ala  Ala Ala Cys 
    5750                 5755                 5760             


Thr Cys  Thr Thr Gly Thr Thr  Ala Cys Gly Ala Thr  Thr Ala Thr 
    5765                 5770                 5775             


Ala Cys  Ala Ala Gly Gly Gly  Thr Gly Ala Gly Cys  Thr Thr Gly 
    5780                 5785                 5790             


Ala Gly  Cys Ala Ala Ala Gly  Gly Thr Gly Cys Thr  Gly Thr Cys 
    5795                 5800                 5805             


Thr Thr  Thr Gly Gly Thr Gly  Gly Ala Ala Gly Ala  Ala Ala Cys 
    5810                 5815                 5820             


Gly Thr  Ala Gly Thr Thr Thr  Thr Gly Ala Gly Thr  Thr Gly Thr 
    5825                 5830                 5835             


Thr Thr  Gly Cys Thr Cys Thr  Thr Thr Gly Ala Cys  Ala Gly Thr 
    5840                 5845                 5850             


Cys Thr  Cys Thr Gly Ala Thr  Gly Gly Cys Ala Thr  Gly Thr Gly 
    5855                 5860                 5865             


Ala Gly  Thr Cys Thr Gly Gly  Thr Gly Cys Ala Thr  Thr Gly Cys 
    5870                 5875                 5880             


Thr Gly  Thr Gly Gly Gly Cys  Thr Gly Cys Gly Cys  Thr Gly Gly 
    5885                 5890                 5895             


Gly Cys  Ala Cys Ala Ala Gly  Thr Thr Gly Cys Ala  Thr Ala Ala 
    5900                 5905                 5910             


Cys Cys  Cys Gly Cys Thr Thr  Thr Thr Gly Gly Ala  Ala Gly Ala 
    5915                 5920                 5925             


Gly Gly  Ala Gly Ala Cys Ala  Ala Ala Gly Cys Ala  Thr Thr Cys 
    5930                 5935                 5940             


Ala Ala  Ala Gly Cys Cys Cys  Thr Ala Ala Ala Cys  Ala Cys Thr 
    5945                 5950                 5955             


Cys Thr  Gly Thr Thr Gly Gly  Thr Gly Ala Ala Thr  Cys Ala Thr 
    5960                 5965                 5970             


Cys Ala  Thr Gly Thr Thr Thr  Ala Thr Thr Gly Ala  Gly Thr Gly 
    5975                 5980                 5985             


Thr Gly  Cys Thr Thr Thr Thr  Ala Gly Thr Gly Gly  Cys Ala Gly 
    5990                 5995                 6000             


Gly Gly  Cys Cys Cys Thr Gly  Ala Gly Cys Ala Cys  Cys Thr Gly 
    6005                 6010                 6015             


Gly Gly  Ala Ala Ala Gly Gly  Ala Gly Ala Thr Gly  Ala Gly Gly 
    6020                 6025                 6030             


Ala Gly  Cys Gly Cys Thr Gly  Gly Ala Gly Gly Gly  Thr Thr Cys 
    6035                 6040                 6045             


Gly Gly  Ala Gly Cys Ala Gly  Ala Gly Ala Ala Gly  Ala Cys Gly 
    6050                 6055                 6060             


Ala Gly  Ala Cys Ala Ala Thr  Gly Cys Thr Cys Thr  Gly Cys Thr 
    6065                 6070                 6075             


Cys Cys  Ala Ala Gly Cys Gly  Cys Cys Ala Gly Ala  Gly Gly Ala 
    6080                 6085                 6090             


Gly Gly  Cys Thr Thr Cys Thr  Gly Gly Gly Ala Ala  Gly Gly Gly 
    6095                 6100                 6105             


Gly Cys  Thr Gly Thr Cys Thr  Gly Thr Gly Gly Ala  Ala Thr Thr 
    6110                 6115                 6120             


Thr Cys  Thr Gly Ala Cys Cys  Cys Cys Cys Ala Gly  Ala Gly Cys 
    6125                 6130                 6135             


Cys Cys  Thr Gly Cys Thr Gly  Gly Thr Gly Ala Ala  Gly Thr Cys 
    6140                 6145                 6150             


Thr Thr  Gly Cys Ala Ala Cys  Cys Ala Cys Thr Ala  Ala Ala Gly 
    6155                 6160                 6165             


Cys Thr  Thr Thr Gly Cys Cys  Ala Gly Ala Gly Ala  Ala Gly Ala 
    6170                 6175                 6180             


Gly Gly  Ala Gly Gly Gly Ala  Cys Cys Thr Gly Ala  Cys Ala Cys 
    6185                 6190                 6195             


Thr Gly  Gly Gly Cys Ala Gly  Thr Gly Gly Cys Gly  Gly Thr Gly 
    6200                 6205                 6210             


Cys Cys  Ala Gly Cys Ala Gly  Thr Gly Ala Gly Cys  Ala Cys Ala 
    6215                 6220                 6225             


Gly Gly  Cys Gly Gly Gly Gly  Thr Cys Thr Ala Gly  Gly Thr Gly 
    6230                 6235                 6240             


Gly Gly  Ala Thr Cys Ala Cys  Thr Gly Ala Ala Gly  Cys Cys Ala 
    6245                 6250                 6255             


Ala Gly  Cys Cys Ala Ala Gly  Thr Gly Gly Thr Gly  Cys Ala Gly 
    6260                 6265                 6270             


Gly Gly  Gly Gly Ala Gly Cys  Cys Gly Cys Cys Cys  Thr Gly Gly 
    6275                 6280                 6285             


Ala Cys  Cys Ala Ala Cys Ala  Cys Cys Cys Cys Cys  Ala Thr Gly 
    6290                 6295                 6300             


Gly Cys  Thr Gly Cys Cys Cys  Cys Ala Cys Thr Gly  Cys Gly Gly 
    6305                 6310                 6315             


Ala Ala  Cys Thr Gly Cys Cys  Thr Ala Cys Thr Gly  Cys Gly Gly 
    6320                 6325                 6330             


Cys Ala  Ala Ala Ala Cys Ala  Ala Thr Cys Cys Thr  Ala Thr Gly 
    6335                 6340                 6345             


Thr Cys  Cys Cys Cys Cys Ala  Ala Gly Gly Thr Thr  Thr Cys Ala 
    6350                 6355                 6360             


Ala Cys  Ala Ala Ala Gly Ala  Gly Gly Ala Gly Gly  Ala Cys Cys 
    6365                 6370                 6375             


Gly Ala  Ala Thr Ala Ala Ala  Thr Gly Thr Cys Cys  Cys Ala Gly 
    6380                 6385                 6390             


Thr Gly  Gly Gly Cys Ala Gly  Gly Cys Ala Cys Ala  Cys Cys Cys 
    6395                 6400                 6405             


Ala Cys  Ala Ala Gly Ala Cys  Thr Thr Gly Cys Thr  Gly Cys Thr 
    6410                 6415                 6420             


Cys Cys  Thr Cys Cys Thr Gly  Ala Cys Cys Cys Ala  Cys Cys Cys 
    6425                 6430                 6435             


Gly Cys  Ala Thr Gly Gly Cys  Thr Cys Thr Gly Cys  Ala Cys Ala 
    6440                 6445                 6450             


Gly Cys  Thr Gly Thr Gly Ala  Gly Thr Cys Cys Ala  Gly Thr Thr 
    6455                 6460                 6465             


Thr Thr  Cys Thr Cys Thr Cys  Thr Thr Cys Cys Thr  Ala Cys Cys 
    6470                 6475                 6480             


Thr Cys  Cys Cys Thr Cys Thr  Thr Ala Cys Cys Cys  Ala Gly Thr 
    6485                 6490                 6495             


Thr Ala  Thr Cys Cys Thr Gly  Ala Cys Cys Cys Cys  Ala Gly Gly 
    6500                 6505                 6510             


Gly Thr  Gly Ala Gly Gly Thr  Thr Gly Ala Ala Ala  Cys Thr Cys 
    6515                 6520                 6525             


Ala Thr  Gly Cys Thr Ala Gly  Gly Cys Thr Ala Ala  Cys Ala Thr 
    6530                 6535                 6540             


Cys Thr  Cys Thr Thr Thr Cys  Cys Thr Thr Cys Ala  Thr Cys Cys 
    6545                 6550                 6555             


Cys Ala  Thr Thr Cys Ala Thr  Ala Ala Ala Ala Cys  Thr Gly Gly 
    6560                 6565                 6570             


Cys Ala  Thr Ala Cys Ala Gly  Gly Ala Ala Thr Gly  Thr Thr Thr 
    6575                 6580                 6585             


Thr Ala  Ala Ala Ala Ala Ala  Ala Thr Cys Thr Thr  Thr Ala Ala 
    6590                 6595                 6600             


Gly Ala  Thr Thr Ala Cys Cys  Ala Gly Gly Ala Gly  Thr Ala Thr 
    6605                 6610                 6615             


Ala Ala  Ala Ala Gly Thr Thr  Ala Ala Ala Ala Thr  Gly Ala Cys 
    6620                 6625                 6630             


Ala Ala  Ala Ala Thr Thr Ala  Cys Ala Gly Gly Cys  Cys Thr Gly 
    6635                 6640                 6645             


Thr Thr  Ala Cys Cys Ala Gly  Ala Thr Cys Thr Thr  Cys Gly Thr 
    6650                 6655                 6660             


Ala Cys  Thr Ala Ala Cys Cys  Ala Ala Gly Gly Ala  Gly Cys Thr 
    6665                 6670                 6675             


Gly Gly  Thr Gly Ala Cys Ala  Cys Thr Ala Cys Cys  Cys Thr Cys 
    6680                 6685                 6690             


Thr Thr  Cys Cys Cys Thr Gly  Thr Gly Thr Gly Ala  Thr Ala Gly 
    6695                 6700                 6705             


Ala Ala  Ala Ala Thr Gly Cys  Ala Gly Ala Cys Gly  Thr Thr Thr 
    6710                 6715                 6720             


Thr Gly  Cys Ala Gly Gly Cys  Ala Gly Ala Cys Cys  Thr Gly Gly 
    6725                 6730                 6735             


Thr Thr  Cys Ala Thr Gly Ala  Cys Thr Cys Ala Gly  Cys Gly Cys 
    6740                 6745                 6750             


Thr Gly  Thr Gly Ala Cys Thr  Thr Gly Thr Gly Gly  Ala Cys Thr 
    6755                 6760                 6765             


Thr Ala  Thr Cys Thr Thr Gly  Thr Gly Cys Ala Gly  Cys Thr Ala 
    6770                 6775                 6780             


Cys Ala  Thr Cys Ala Cys Thr  Thr Cys Thr Thr Ala  Gly Cys Cys 
    6785                 6790                 6795             


Thr Thr  Gly Thr Thr Thr Thr  Cys Ala Ala Cys Ala  Thr Gly Cys 
    6800                 6805                 6810             


Gly Thr  Ala Ala Gly Cys Ala  Gly Ala Ala Gly Gly  Thr Ala Cys 
    6815                 6820                 6825             


Thr Ala  Ala Thr Ala Thr Thr  Ala Gly Thr Cys Thr  Thr Thr Ala 
    6830                 6835                 6840             


Gly Gly  Gly Cys Thr Gly Gly  Thr Thr Thr Gly Ala  Gly Gly Ala 
    6845                 6850                 6855             


Thr Gly  Ala Cys Gly Thr Gly  Ala Gly Ala Thr Gly  Ala Gly Ala 
    6860                 6865                 6870             


Gly Ala  Cys Ala Ala Cys Cys  Ala Ala Gly Cys Ala  Cys Thr Cys 
    6875                 6880                 6885             


Ala Cys  Thr Gly Gly Cys Ala  Gly Thr Thr Cys Cys  Thr Ala Gly 
    6890                 6895                 6900             


Ala Ala  Gly Ala Thr Thr Cys  Cys Ala Gly Thr Ala  Gly Thr Ala 
    6905                 6910                 6915             


Gly Ala  Gly Ala Thr Cys Thr  Gly Ala Cys Thr Gly  Thr Cys Cys 
    6920                 6925                 6930             


Thr Ala  Cys Ala Cys Thr Ala  Cys Thr Thr Thr Cys  Cys Cys Thr 
    6935                 6940                 6945             


Cys Cys  Cys Thr Gly Thr Cys  Thr Cys Thr Gly Ala  Cys Ala Cys 
    6950                 6955                 6960             


Thr Thr  Gly Thr Thr Cys Ala  Thr Thr Cys Cys Thr  Gly Gly Gly 
    6965                 6970                 6975             


Cys Thr  Cys Ala Gly Gly Ala  Gly Cys Cys Ala Thr  Cys Thr Cys 
    6980                 6985                 6990             


Ala Gly  Thr Cys Ala Thr Cys  Ala Thr Gly Thr Cys  Gly Gly Ala 
    6995                 7000                 7005             


Cys Cys  Ala Cys Gly Thr Ala  Ala Cys Thr Ala Thr  Ala Ala Cys 
    7010                 7015                 7020             


Cys Ala  Ala Gly Cys Thr Cys  Thr Gly Cys Thr Gly  Cys Cys Cys 
    7025                 7030                 7035             


Ala Cys  Cys Thr Gly Gly Gly  Ala Cys Ala Cys Cys  Thr Thr Cys 
    7040                 7045                 7050             


Cys Cys  Ala Cys Thr Cys Thr  Thr Thr Gly Cys Ala  Ala Cys Thr 
    7055                 7060                 7065             


Ala Gly  Gly Thr Cys Gly Gly  Ala Gly Gly Gly Ala  Cys Gly Cys 
    7070                 7075                 7080             


Ala Cys  Cys Thr Thr Cys Thr  Cys Cys Ala Cys Ala  Gly Thr Thr 
    7085                 7090                 7095             


Gly Ala  Cys Ala Gly Gly Ala  Cys Thr Gly Thr Thr  Ala Thr Gly 
    7100                 7105                 7110             


Gly Thr  Thr Gly Ala Cys Cys  Cys Ala Ala Ala Ala  Gly Thr Thr 
    7115                 7120                 7125             


Gly Thr  Cys Ala Thr Cys Thr  Thr Cys Thr Gly Ala  Cys Ala Thr 
    7130                 7135                 7140             


Gly Ala  Cys Ala Cys Ala Cys  Thr Gly Ala Gly Gly  Gly Ala Ala 
    7145                 7150                 7155             


Gly Thr  Ala Gly Ala Cys Thr  Thr Ala Cys Cys Cys  Ala Ala Thr 
    7160                 7165                 7170             


Ala Thr  Ala Ala Cys Thr Thr  Cys Ala Cys Ala Thr  Thr Ala Thr 
    7175                 7180                 7185             


Ala Cys  Thr Gly Thr Cys Thr  Thr Ala Ala Ala Ala  Gly Ala Cys 
    7190                 7195                 7200             


Thr Ala  Thr Gly Ala Thr Thr  Ala Ala Ala Ala Thr  Gly Gly Gly 
    7205                 7210                 7215             


Cys Ala  Thr Cys Ala Gly Thr  Gly Thr Ala Gly Gly  Cys Ala Ala 
    7220                 7225                 7230             


Cys Ala  Thr Gly Thr Ala Gly  Gly Gly Cys Gly Cys  Ala Ala Ala 
    7235                 7240                 7245             


Gly Ala  Ala Thr Ala Gly Cys  Cys Ala Gly Ala Thr  Gly Thr Gly 
    7250                 7255                 7260             


Ala Ala  Gly Gly Thr Thr Gly  Ala Ala Ala Gly Gly  Cys Thr Ala 
    7265                 7270                 7275             


Thr Gly  Thr Gly Gly Gly Cys  Thr Ala Gly Thr Thr  Thr Gly Thr 
    7280                 7285                 7290             


Cys Ala  Thr Gly Gly Thr Ala  Thr Thr Cys Cys Thr  Gly Gly Thr 
    7295                 7300                 7305             


Gly Cys  Cys Thr Cys Thr Cys  Cys Cys Cys Gly Thr  Thr Thr Gly 
    7310                 7315                 7320             


Gly Gly  Ala Ala Gly Ala Ala  Thr Ala Ala Cys Ala  Cys Ala Thr 
    7325                 7330                 7335             


Thr Gly  Ala Cys Cys Ala Cys  Cys Gly Gly Cys Thr  Cys Ala Gly 
    7340                 7345                 7350             


Ala Gly  Gly Ala Gly Gly Thr  Gly Gly Cys Ala Thr  Thr Ala Thr 
    7355                 7360                 7365             


Ala Gly  Gly Thr Cys Cys Ala  Gly Gly Cys Cys Cys  Cys Thr Thr 
    7370                 7375                 7380             


Cys Ala  Gly Gly Ala Gly Gly  Gly Cys Ala Cys Thr  Gly Gly Ala 
    7385                 7390                 7395             


Gly Thr  Cys Ala Ala Thr Gly  Ala Ala Ala Gly Cys  Thr Thr Thr 
    7400                 7405                 7410             


Thr Gly  Cys Thr Cys Thr Cys  Ala Cys Cys Cys Ala  Gly Gly Cys 
    7415                 7420                 7425             


Thr Cys  Thr Thr Gly Gly Thr  Thr Thr Cys Thr Cys  Ala Cys Gly 
    7430                 7435                 7440             


Gly Gly  Cys Ala Gly Gly Gly  Gly Thr Ala Gly Cys  Cys Cys Ala 
    7445                 7450                 7455             


Gly Gly  Ala Ala Ala Cys Ala  Ala Ala Gly Gly Cys  Thr Gly Thr 
    7460                 7465                 7470             


Ala Thr  Ala Gly Ala Cys Thr  Thr Thr Ala Ala Gly  Thr Cys Gly 
    7475                 7480                 7485             


Thr Gly  Ala Gly Ala Ala Ala  Ala Ala Cys Gly Ala  Cys Ala Thr 
    7490                 7495                 7500             


Thr Cys  Thr Thr Ala Thr Gly  Gly Thr Gly Ala Gly  Gly Cys Thr 
    7505                 7510                 7515             


Cys Thr  Thr Ala Gly Ala Gly  Ala Cys Thr Gly Thr  Cys Thr Cys 
    7520                 7525                 7530             


Cys Ala  Thr Thr Thr Ala Ala  Gly Cys Ala Gly Cys  Ala Gly Cys 
    7535                 7540                 7545             


Ala Gly  Thr Ala Ala Ala Ala  Cys Ala Thr Cys Thr  Thr Ala Cys 
    7550                 7555                 7560             


Cys Cys  Thr Ala Ala Ala Ala  Thr Gly Ala Ala Gly  Ala Ala Gly 
    7565                 7570                 7575             


Cys Ala  Ala Ala Thr Cys Cys  Ala Thr Thr Thr Thr  Thr Ala Thr 
    7580                 7585                 7590             


Thr Gly  Gly Cys Thr Thr Thr  Thr Ala Thr Ala Gly  Cys Cys Thr 
    7595                 7600                 7605             


Cys Thr  Cys Thr Cys Thr Thr  Thr Cys Ala Ala Thr  Gly Ala Cys 
    7610                 7615                 7620             


Ala Ala  Ala Gly Ala Ala Ala  Cys Cys Ala Thr Thr  Ala Ala Ala 
    7625                 7630                 7635             


Ala Thr  Gly Ala Ala Thr Gly  Thr Thr Thr Ala Ala  Ala Gly Thr 
    7640                 7645                 7650             


Thr Cys  Thr Thr Ala Gly Ala  Ala Gly Ala Gly Cys  Thr Thr Thr 
    7655                 7660                 7665             


Cys Thr  Cys Thr Ala Ala Ala  Thr Ala Thr Thr Thr  Ala Cys Thr 
    7670                 7675                 7680             


Cys Thr  Gly Thr Cys Ala Gly  Thr Gly Gly Ala Ala  Ala Ala Ala 
    7685                 7690                 7695             


Thr Ala  Ala Ala Cys Ala Thr  Thr Thr Thr Thr Thr  Ala Cys Ala 
    7700                 7705                 7710             


Thr Cys  Gly Gly Gly Thr Cys  Thr Ala Thr Thr Gly  Ala Gly Thr 
    7715                 7720                 7725             


Thr Thr  Gly Thr Thr Ala Thr  Ala Thr Ala Cys Ala  Gly Thr Ala 
    7730                 7735                 7740             


Ala Ala  Ala Thr Thr Cys Ala  Cys Cys Cys Thr Thr  Thr Thr Thr 
    7745                 7750                 7755             


Ala Gly  Ala Thr Ala Thr Ala  Thr Ala Gly Thr Thr  Thr Thr Ala 
    7760                 7765                 7770             


Thr Gly  Ala Gly Thr Thr Thr  Thr Ala Ala Cys Ala  Ala Ala Ala 
    7775                 7780                 7785             


Ala Thr  Ala Cys Ala Thr Ala  Gly Thr Thr Gly Thr  Gly Thr Ala 
    7790                 7795                 7800             


Ala Cys  Cys Ala Cys Cys Ala  Cys Cys Ala Thr Cys  Ala Cys Ala 
    7805                 7810                 7815             


Ala Thr  Cys Ala Ala Gly Ala  Thr Ala Thr Ala Gly  Ala Ala Thr 
    7820                 7825                 7830             


Ala Thr  Thr Thr Cys Ala Ala  Cys Ala Thr Cys Cys  Cys Ala Ala 
    7835                 7840                 7845             


Ala Gly  Thr Thr Cys Cys Cys  Ala Thr Thr Thr Cys  Cys Cys Thr 
    7850                 7855                 7860             


Thr Thr  Thr Cys Ala Gly Thr  Cys Ala Ala Thr Cys  Cys Cys Thr 
    7865                 7870                 7875             


Thr Cys  Cys Cys Cys Ala Cys  Thr Ala Cys Cys Cys  Cys Thr Ala 
    7880                 7885                 7890             


Gly Cys  Cys Cys Cys Thr Gly  Gly Cys Ala Ala Cys  Cys Ala Thr 
    7895                 7900                 7905             


Thr Ala  Thr Cys Thr Gly Thr  Thr Cys Thr Cys Thr  Cys Thr Thr 
    7910                 7915                 7920             


Cys Cys  Cys Ala Thr Ala Gly  Thr Thr Thr Cys Ala  Cys Cys Thr 
    7925                 7930                 7935             


Thr Thr  Thr Cys Cys Ala Ala  Thr Thr Thr Gly Thr  Cys Gly Thr 
    7940                 7945                 7950             


Gly Thr  Ala Gly Ala Gly Thr  Thr Ala Cys Ala Cys  Ala Gly Cys 
    7955                 7960                 7965             


Thr Cys  Ala Thr Ala Gly Cys  Cys Ala Thr Thr Thr  Gly Ala Gly 
    7970                 7975                 7980             


Thr Cys  Thr Gly Gly Cys Thr  Thr Cys Thr Thr Thr  Cys Cys Ala 
    7985                 7990                 7995             


Cys Ala  Thr Ala Ala Thr Gly  Thr Cys Cys Thr Thr  Gly Ala Gly 
    8000                 8005                 8010             


Ala Thr  Cys Cys Ala Thr Cys  Gly Gly Thr Gly Gly  Gly Thr Ala 
    8015                 8020                 8025             


Cys Ala  Cys Cys Ala Gly Thr  Ala Gly Thr Thr Cys  Cys Ala Thr 
    8030                 8035                 8040             


Thr Thr  Thr Thr Thr Thr Thr  Cys Thr Gly Ala Gly  Thr Ala Gly 
    8045                 8050                 8055             


Thr Ala  Gly Thr Cys Cys Ala  Thr Thr Gly Thr Ala  Thr Gly Gly 
    8060                 8065                 8070             


Ala Thr  Gly Thr Ala Cys Thr  Gly Cys Gly Gly Thr  Thr Thr Ala 
    8075                 8080                 8085             


Thr Thr  Cys Ala Cys Cys Ala  Ala Cys Ala Thr Ala  Thr Gly Gly 
    8090                 8095                 8100             


Gly Thr  Thr Cys Thr Thr Thr  Cys Cys Thr Gly Thr  Thr Thr Gly 
    8105                 8110                 8115             


Gly Gly  Gly Ala Gly Ala Thr  Thr Ala Cys Ala Ala  Ala Thr Ala 
    8120                 8125                 8130             


Ala Ala  Gly Cys Thr Ala Cys  Thr Ala Thr Ala Ala  Ala Ala Ala 
    8135                 8140                 8145             


<210>  31
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Arg Arg Ala Ser Arg Asp Tyr Thr Lys Tyr Leu Arg Gly Ser Glu 
1               5                   10                  15      


Glu Met Gly Gly Gly Pro Gly Ala Pro His Glu Gly Pro Leu His Ala 
            20                  25                  30          


Pro Pro Pro Pro Ala Pro His Gln Pro Pro Ala Ala Ser Arg Ser Met 
        35                  40                  45              


Phe Val Ala Leu Leu Gly Leu Gly Leu Gly Gln Val Val Cys Ser Val 
    50                  55                  60                  


Ala Leu Phe Phe Tyr Phe Arg Ala Gln Met Asp Pro Asn Arg Ile Ser 
65                  70                  75                  80  


Glu Asp Gly Thr His Cys Ile Tyr Arg Ile Leu Arg Leu His Glu Asn 
                85                  90                  95      


Ala Asp Phe Gln Asp Thr Thr Leu Glu Ser Gln Asp Thr Lys Leu Ile 
            100                 105                 110         


Pro Asp Ser Cys Arg Arg Ile Lys Gln Ala Phe Gln Gly Ala Val Gln 
        115                 120                 125             


Lys Glu Leu Gln His Ile Val Gly Ser Gln His Ile Arg Ala Glu Lys 
    130                 135                 140                 


Ala Met Val Asp Gly Ser Trp Leu Asp Leu Ala Lys Arg Ser Lys Leu 
145                 150                 155                 160 


Glu Ala Gln Pro Phe Ala His Leu Thr Ile Asn Ala Thr Asp Ile Pro 
                165                 170                 175     


Ser Gly Ser His Lys Val Ser Leu Ser Ser Trp Tyr His Asp Arg Gly 
            180                 185                 190         


Trp Ala Lys Ile Ser Asn Met Thr Phe Ser Asn Gly Lys Leu Ile Val 
        195                 200                 205             


Asn Gln Asp Gly Phe Tyr Tyr Leu Tyr Ala Asn Ile Cys Phe Arg His 
    210                 215                 220                 


His Glu Thr Ser Gly Asp Leu Ala Thr Glu Tyr Leu Gln Leu Met Val 
225                 230                 235                 240 


Tyr Val Thr Lys Thr Ser Ile Lys Ile Pro Ser Ser His Thr Leu Met 
                245                 250                 255     


Lys Gly Gly Ser Thr Lys Tyr Trp Ser Gly Asn Ser Glu Phe His Phe 
            260                 265                 270         


Tyr Ser Ile Asn Val Gly Gly Phe Phe Lys Leu Arg Ser Gly Glu Glu 
        275                 280                 285             


Ile Ser Ile Glu Val Ser Asn Pro Ser Leu Leu Asp Pro Asp Gln Asp 
    290                 295                 300                 


Ala Thr Tyr Phe Gly Ala Phe Lys Val Arg Asp Ile Asp 
305                 310                 315         


<210>  32
<211>  2201
<212>  DNA
<213>  Homo sapiens

<400>  32
gcccgctcgc ccgcgcgccc caggacccaa agccgggctc caagtcggcg ccccacgtcg       60

aggctccgcc gcagcctccg gagttggccg cagacaagaa ggggagggag cgggagaggg      120

aggagagctc cgaagcgaga gggccgagcg ccatgcgccg cgccagcaga gactacacca      180

agtacctgcg tggctcggag gagatgggcg gcggccccgg agccccgcac gagggccccc      240

tgcacgcccc gccgccgcct gcgccgcacc agccccctgc cgcctcccgc tccatgttcg      300

tggccctcct ggggctgggg ctgggccagg ttgtctgcag cgtcgccctg ttcttctatt      360

tcagagcgca gatggatcct aatagaatat cagaagatgg cactcactgc atttatagaa      420

ttttgagact ccatgaaaat gcagattttc aagacacaac tctggagagt caagatacaa      480

aattaatacc tgattcatgt aggagaatta aacaggcctt tcaaggagct gtgcaaaagg      540

aattacaaca tatcgttgga tcacagcaca tcagagcaga gaaagcgatg gtggatggct      600

catggttaga tctggccaag aggagcaagc ttgaagctca gccttttgct catctcacta      660

ttaatgccac cgacatccca tctggttccc ataaagtgag tctgtcctct tggtaccatg      720

atcggggttg ggccaagatc tccaacatga cttttagcaa tggaaaacta atagttaatc      780

aggatggctt ttattacctg tatgccaaca tttgctttcg acatcatgaa acttcaggag      840

acctagctac agagtatctt caactaatgg tgtacgtcac taaaaccagc atcaaaatcc      900

caagttctca taccctgatg aaaggaggaa gcaccaagta ttggtcaggg aattctgaat      960

tccattttta ttccataaac gttggtggat tttttaagtt acggtctgga gaggaaatca     1020

gcatcgaggt ctccaacccc tccttactgg atccggatca ggatgcaaca tactttgggg     1080

cttttaaagt tcgagatata gattgagccc cagtttttgg agtgttatgt atttcctgga     1140

tgtttggaaa cattttttaa aacaagccaa gaaagatgta tataggtgtg tgagactact     1200

aagaggcatg gccccaacgg tacacgactc agtatccatg ctcttgacct tgtagagaac     1260

acgcgtattt acagccagtg ggagatgtta gactcatggt gtgttacaca atggttttta     1320

aattttgtaa tgaattccta gaattaaacc agattggagc aattacgggg tgaccttatg     1380

agaaactgca tgtgggctat gggaggggtt ggtccctggt catgtgcccc ttcgcagctg     1440

aagtggagag ggtgtcatct agcgcaattg aaggatcatc tgaaggggca aattcttttg     1500

aattgttaca tcatgctgga acctgcaaaa aatacttttt ctaatgagga gagaaaatat     1560

atgtattttt atataatatc taaagttata tttcagatgt aatgttttct ttgcaaagta     1620

ttgtaaatta tatttgtgct atagtatttg attcaaaata tttaaaaatg tcttgctgtt     1680

gacatattta atgttttaaa tgtacagaca tatttaactg gtgcactttg taaattccct     1740

ggggaaaact tgcagctaag gaggggaaaa aaatgttgtt tcctaatatc aaatgcagta     1800

tatttcttcg ttctttttaa gttaatagat tttttcagac ttgtcaagcc tgtgcaaaaa     1860

aattaaaatg gatgccttga ataataagca ggatgttggc caccaggtgc ctttcaaatt     1920

tagaaactaa ttgactttag aaagctgaca ttgccaaaaa ggatacataa tgggccactg     1980

aaatctgtca agagtagtta tataattgtt gaacaggtgt ttttccacaa gtgccgcaaa     2040

ttgtaccttt tttgtttttt caaaatagaa aagttattag tggtttatca gcaaaaaagt     2100

ccaattttaa tttagtaaat gttatcttat actgtacaat aaaaacattg cctttgaatg     2160

ttaatttttt ggtacaaaaa taaatttata tgaaaacctg c                         2201


