﻿               SEQUENCE LISTING

<110> UNIVERSITÉ CATHOLIQUE DE LOUVAIN
      SONVEAUX Pierre
      FRÉDÉRICK Raphaël
      THABAULT Léopold
      BRISSON Lucie
      COPETTI Tamara

<120> LACTATE DEHYDROGENASE INHIBITOR POLYPEPTIDES FOR USE IN THE TREATMENT OF CANCER

<130> CV-483/PCT

<150> EP20161569.7
<151> 2020-03-06
<150> EP19172347.7
<151> 2019-05-02

<160> 68

<170> BiSSAP 1.3.6

<210> 1
<211> 332
<212> PRT
<213> Homo sapiens


<220> 
<223> hLDHA subunit

<400> 1
Met Ala Thr Leu Lys Asp Gln Leu Ile Tyr Asn Leu Leu Lys Glu Glu 
1               5                   10                  15      
Gln Thr Pro Gln Asn Lys Ile Thr Val Val Gly Val Gly Ala Val Gly 
            20                  25                  30          
Met Ala Cys Ala Ile Ser Ile Leu Met Lys Asp Leu Ala Asp Glu Leu 
        35                  40                  45              
Ala Leu Val Asp Val Ile Glu Asp Lys Leu Lys Gly Glu Met Met Asp 
    50                  55                  60                  
Leu Gln His Gly Ser Leu Phe Leu Arg Thr Pro Lys Ile Val Ser Gly 
65                  70                  75                  80  
Lys Asp Tyr Asn Val Thr Ala Asn Ser Lys Leu Val Ile Ile Thr Ala 
                85                  90                  95      
Gly Ala Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln Arg 
            100                 105                 110         
Asn Val Asn Ile Phe Lys Phe Ile Ile Pro Asn Val Val Lys Tyr Ser 
        115                 120                 125             
Pro Asn Cys Lys Leu Leu Ile Val Ser Asn Pro Val Asp Ile Leu Thr 
    130                 135                 140                 
Tyr Val Ala Trp Lys Ile Ser Gly Phe Pro Lys Asn Arg Val Ile Gly 
145                 150                 155                 160 
Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Gly Glu 
                165                 170                 175     
Arg Leu Gly Val His Pro Leu Ser Cys His Gly Trp Val Leu Gly Glu 
            180                 185                 190         
His Gly Asp Ser Ser Val Pro Val Trp Ser Gly Met Asn Val Ala Gly 
        195                 200                 205             
Val Ser Leu Lys Thr Leu His Pro Asp Leu Gly Thr Asp Lys Asp Lys 
    210                 215                 220                 
Glu Gln Trp Lys Glu Val His Lys Gln Val Val Glu Ser Ala Tyr Glu 
225                 230                 235                 240 
Val Ile Lys Leu Lys Gly Tyr Thr Ser Trp Ala Ile Gly Leu Ser Val 
                245                 250                 255     
Ala Asp Leu Ala Glu Ser Ile Met Lys Asn Leu Arg Arg Val His Pro 
            260                 265                 270         
Val Ser Thr Met Ile Lys Gly Leu Tyr Gly Ile Lys Asp Asp Val Phe 
        275                 280                 285             
Leu Ser Val Pro Cys Ile Leu Gly Gln Asn Gly Ile Ser Asp Leu Val 
    290                 295                 300                 
Lys Val Thr Leu Thr Ser Glu Glu Glu Ala Arg Leu Lys Lys Ser Ala 
305                 310                 315                 320 
Asp Thr Leu Trp Gly Ile Gln Lys Glu Leu Gln Phe 
                325                 330         

<210> 2
<211> 334
<212> PRT
<213> Homo sapiens


<220> 
<223> hLDHB subunit

<400> 2
Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu 
1               5                   10                  15      
Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val 
            20                  25                  30          
Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu 
        35                  40                  45              
Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met 
    50                  55                  60                  
Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala 
65                  70                  75                  80  
Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr 
                85                  90                  95      
Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln 
            100                 105                 110         
Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr 
        115                 120                 125             
Ser Pro Asp Cys Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu 
    130                 135                 140                 
Thr Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile 
145                 150                 155                 160 
Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala 
                165                 170                 175     
Glu Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly 
            180                 185                 190         
Glu His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala 
        195                 200                 205             
Gly Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp 
    210                 215                 220                 
Ser Glu Asn Trp Lys Glu Val His Lys Met Val Val Glu Ser Ala Tyr 
225                 230                 235                 240 
Glu Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser 
                245                 250                 255     
Val Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His 
            260                 265                 270         
Pro Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val 
        275                 280                 285             
Phe Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val 
    290                 295                 300                 
Ile Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser 
305                 310                 315                 320 
Ala Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu 
                325                 330                 

<210> 3
<211> 312
<212> PRT
<213> Artificial Sequence


<220> 
<223> hLDHAtr

<400> 3
Asn Lys Ile Thr Val Val Gly Val Gly Ala Val Gly Met Ala Cys Ala 
1               5                   10                  15      
Ile Ser Ile Leu Met Lys Asp Leu Ala Asp Glu Leu Ala Leu Val Asp 
            20                  25                  30          
Val Ile Glu Asp Lys Leu Lys Gly Glu Met Met Asp Leu Gln His Gly 
        35                  40                  45              
Ser Leu Phe Leu Arg Thr Pro Lys Ile Val Ser Gly Lys Asp Tyr Asn 
    50                  55                  60                  
Val Thr Ala Asn Ser Lys Leu Val Ile Ile Thr Ala Gly Ala Arg Gln 
65                  70                  75                  80  
Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln Arg Asn Val Asn Ile 
                85                  90                  95      
Phe Lys Phe Ile Ile Pro Asn Val Val Lys Tyr Ser Pro Asn Cys Lys 
            100                 105                 110         
Leu Leu Ile Val Ser Asn Pro Val Asp Ile Leu Thr Tyr Val Ala Trp 
        115                 120                 125             
Lys Ile Ser Gly Phe Pro Lys Asn Arg Val Ile Gly Ser Gly Cys Asn 
    130                 135                 140                 
Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Gly Glu Arg Leu Gly Val 
145                 150                 155                 160 
His Pro Leu Ser Cys His Gly Trp Val Leu Gly Glu His Gly Asp Ser 
                165                 170                 175     
Ser Val Pro Val Trp Ser Gly Met Asn Val Ala Gly Val Ser Leu Lys 
            180                 185                 190         
Thr Leu His Pro Asp Leu Gly Thr Asp Lys Asp Lys Glu Gln Trp Lys 
        195                 200                 205             
Glu Val His Lys Gln Val Val Glu Ser Ala Tyr Glu Val Ile Lys Leu 
    210                 215                 220                 
Lys Gly Tyr Thr Ser Trp Ala Ile Gly Leu Ser Val Ala Asp Leu Ala 
225                 230                 235                 240 
Glu Ser Ile Met Lys Asn Leu Arg Arg Val His Pro Val Ser Thr Met 
                245                 250                 255     
Ile Lys Gly Leu Tyr Gly Ile Lys Asp Asp Val Phe Leu Ser Val Pro 
            260                 265                 270         
Cys Ile Leu Gly Gln Asn Gly Ile Ser Asp Leu Val Lys Val Thr Leu 
        275                 280                 285             
Thr Ser Glu Glu Glu Ala Arg Leu Lys Lys Ser Ala Asp Thr Leu Trp 
    290                 295                 300                 
Gly Ile Gln Lys Glu Leu Gln Phe 
305                 310         

<210> 4
<211> 314
<212> PRT
<213> Artificial Sequence


<220> 
<223> hLDHBtr

<400> 4
Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val Gly Met Ala Cys 
1               5                   10                  15      
Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu Leu Ala Leu Val 
            20                  25                  30          
Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met Asp Leu Gln His 
        35                  40                  45              
Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala Asp Lys Asp Tyr 
    50                  55                  60                  
Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr Ala Gly Val Arg 
65                  70                  75                  80  
Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln Arg Asn Val Asn 
                85                  90                  95      
Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr Ser Pro Asp Cys 
            100                 105                 110         
Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu Thr Tyr Val Thr 
        115                 120                 125             
Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile Gly Ser Gly Cys 
    130                 135                 140                 
Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala Glu Lys Leu Gly 
145                 150                 155                 160 
Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly Glu His Gly Asp 
                165                 170                 175     
Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala Gly Val Ser Leu 
            180                 185                 190         
Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp Ser Glu Asn Trp 
        195                 200                 205             
Lys Glu Val His Lys Met Val Val Glu Ser Ala Tyr Glu Val Ile Lys 
    210                 215                 220                 
Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser Val Ala Asp Leu 
225                 230                 235                 240 
Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His Pro Val Ser Thr 
                245                 250                 255     
Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val Phe Leu Ser Leu 
            260                 265                 270         
Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val Ile Asn Gln Lys 
        275                 280                 285             
Leu Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser Ala Asp Thr Leu 
    290                 295                 300                 
Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu 
305                 310                 

<210> 5
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> X represents any amino acid residue, preferentially selected from
      the group consisting of amino acid residues A, G, K and C

<220> 
<223> LBX

<220> 
<221> SITE
<222> 2
<223> X represents C, T or S

<220> 
<221> SITE
<222> 3
<223> X represents C, L, A, T, cpA (cyclopropyl-L-alanine), chG
      (L-cyclohexylglycine), chA (cyclohexyl-L-alanine) or mlL
      (γ-methyl-L-leucine)

<220> 
<221> SITE
<222> 4
<223> X represents any amino acid residue, preferentially a positively
      charged or neutral amino acid residue, preferentially selected
      from the group consisting of amino acid residues K, C, A and Aib
      (2-aminoisobutyric acid), and more preferentially amino acid K

<220> 
<221> SITE
<222> 5
<223> X represents any amino acid residue, preferentially a negatively
      or positively charged or neutral amino acid residue,
      preferentially selected from the group consisting of amino acid
      residues E, D, K, A and C, and more preferentially amino acid E

<220> 
<221> SITE
<222> 6
<223> X represents any amino acid residue, preferentially a negatively
      or positively charged or neutral amino acid residue, preferential
      ly selected fr om the group consisting of amino acid residues E,
      K, Q, A, Aib (2-am inoisobutyric acid) and C, and more preferent

<220> 
<221> SITE
<222> 7
<223> X represents C, L, I, cpA (cyclopropyl-L-alanine), chG
      (L-cyclohexylglycine), chA (cyclohexyl-L-alanine) or mlL
      (γ-methyl-L-leucine)

<220> 
<221> SITE
<222> 8
<223> X represents C, I or G

<400> 5
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               

<210> 6
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> LB19

<400> 6
Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu Ala 
1               5                   10                  15      
Thr Val Pro 
            

<210> 7
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> LB13

<400> 7
Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu 
1               5                   10              

<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> LB8

<400> 8
Ala Thr Leu Lys Glu Lys Leu Ile 
1               5               

<210> 9
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> LB8-A2

<400> 9
Ala Thr Ala Lys Glu Lys Leu Ile 
1               5               

<210> 10
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> LB8-A3

<400> 10
Ala Thr Leu Ala Glu Lys Leu Ile 
1               5               

<210> 11
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> LB8-A4

<400> 11
Ala Thr Leu Lys Ala Lys Leu Ile 
1               5               

<210> 12
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> LB8-A5

<400> 12
Ala Thr Leu Lys Glu Ala Leu Ile 
1               5               

<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> LB8-A7

<400> 13
Ala Thr Leu Lys Glu Lys Leu Ala 
1               5               

<210> 14
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> MOD_RES
<222> 1
<223> ACETYLATION

<220> 
<223> Ac-LB8

<400> 14
Ala Thr Leu Lys Glu Lys Leu Ile 
1               5               

<210> 15
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> LB8-A3-A5

<400> 15
Ala Thr Leu Ala Glu Ala Leu Ile 
1               5               

<210> 16
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> LB8-G1

<400> 16
Gly Thr Leu Lys Glu Lys Leu Ile 
1               5               

<210> 17
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> LB8-G8

<400> 17
Ala Thr Leu Lys Glu Lys Leu Gly 
1               5               

<210> 18
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> LB8-Aib1

<220> 
<221> MOD_RES
<222> 4
<223> aib

<220> 
<221> MOD_RES
<222> 4
<223> Aib

<400> 18
Ala Thr Leu Xaa Glu Lys Leu Ile 
1               5               

<210> 19
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> LB8-Aib2

<220> 
<221> MOD_RES
<222> 6
<223> Aib

<400> 19
Ala Thr Leu Lys Glu Xaa Leu Ile 
1               5               

<210> 20
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> LB8-Aib3

<220> 
<221> MOD_RES
<222> 4
<223> Aib

<220> 
<221> MOD_RES
<222> 6
<223> Aib

<400> 20
Ala Thr Leu Xaa Glu Xaa Leu Ile 
1               5               

<210> 21
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> LA19

<400> 21
Ala Thr Leu Lys Asp Gln Leu Ile Tyr Asn Leu Leu Lys Glu Glu Gln 
1               5                   10                  15      
Thr Pro Gln 
            

<210> 22
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> LA8

<400> 22
Ala Thr Leu Lys Asp Gln Leu Ile 
1               5               

<210> 23
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> LB8-A1

<400> 23
Ala Ala Leu Lys Glu Lys Leu Ile 
1               5               

<210> 24
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> LB8-A6

<400> 24
Ala Thr Leu Lys Glu Lys Ala Ile 
1               5               

<210> 25
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> LB8-AL7

<400> 25
Ala Thr Leu Lys Glu Lys Leu 
1               5           

<210> 26
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<221> MOD_RES
<222> 1
<223> ACETYLATION

<220> 
<223> LBc

<220> 
<221> MOD_RES
<222> 7
<223> AMIDATION

<400> 26
Leu Ile Ala Pro Val Ala Glu 
1               5           

<210> 27
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<221> MOD_RES
<222> 1
<223> ACETYLATION

<220> 
<223> LB8-AcTI7

<400> 27
Thr Leu Lys Glu Lys Leu Ile 
1               5           

<210> 28
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> LB8-TI7

<400> 28
Thr Leu Lys Glu Lys Leu Ile 
1               5           

<210> 29
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> LB8-G3

<400> 29
Ala Thr Gly Lys Glu Lys Leu Ile 
1               5               

<210> 30
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> VS-142-BisAlk (linker: α, α’ bisbromoxylene)

<400> 30
Ala Cys Leu Lys Glu Cys Leu Ile 
1               5               

<210> 31
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> LT018 (linker: α, α’ bisbromoxylene)

<400> 31
Cys Thr Leu Lys Cys Lys Leu Ile 
1               5               

<210> 32
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> LT020 (linker: α, α’ bisbromoxylene)

<400> 32
Ala Thr Leu Lys Cys Lys Leu Ile Cys 
1               5                   

<210> 33
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> LT021 (linker: α, α’ bisbromoxylene)

<400> 33
Ala Cys Thr Leu Lys Cys Lys Leu Ile 
1               5                   

<210> 34
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> LT022 (linker: α, α’ bisbromoxylene)

<400> 34
Cys Ala Thr Leu Cys Glu Lys Leu Ile 
1               5                   

<210> 35
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CB-09 (linker: α, α’ bisbromoxylene)

<400> 35
Ala Thr Cys Lys Glu Lys Cys Ile 
1               5               

<210> 36
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antennapedia Penetratin CCP

<400> 36
Arg Gln Ile Lys Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15  

<210> 37
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> TAT CCP

<400> 37
Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      

<210> 38
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> SynB1 CCP

<400> 38
Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      
Gly Arg 
        

<210> 39
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> SynB3 CCP

<400> 39
Arg Arg Leu Ser Tyr Ser Arg Arg Arg Phe 
1               5                   10  

<210> 40
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> PTD-4 CCP

<400> 40
Pro Ile Arg Arg Arg Lys Lys Leu Arg Arg Leu Lys 
1               5                   10          

<210> 41
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> PTD-5 CCP

<400> 41
Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          

<210> 42
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> FHV Coat-(35-49) CCP

<400> 42
Arg Arg Arg Arg Asn Arg Thr Arg Arg Asn Arg Arg Arg Val Arg 
1               5                   10                  15  

<210> 43
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> BMV Gag-(7-25) CCP

<400> 43
Lys Met Thr Arg Ala Gln Arg Arg Ala Ala Ala Arg Arg Asn Arg Trp 
1               5                   10                  15      
Thr Ala Arg 
            

<210> 44
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> HTLV-II Rex-(4-16) CCP

<400> 44
Thr Arg Arg Gln Arg Thr Arg Arg Ala Arg Arg Asn Arg 
1               5                   10              

<210> 45
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> D-Tat CCP

<400> 45
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              

<210> 46
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> R9-Tat CCP

<400> 46
Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Pro Pro Gln 
1               5                   10              

<210> 47
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Transportan CCP

<400> 47
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      
Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          

<210> 48
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> MAP CCP

<400> 48
Lys Leu Ala Leu Lys Leu Ala Leu Lys Leu Ala Leu Ala Leu Lys Leu 
1               5                   10                  15      
Ala 
    

<210> 49
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> SBP CCP

<400> 49
Met Gly Leu Gly Leu His Leu Leu Val Leu Ala Ala Ala Leu Gln Gly 
1               5                   10                  15      
Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          

<210> 50
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> FBP CCP

<400> 50
Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      
Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          

<210> 51
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> MPG CCP

<400> 51
Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      
Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          

<210> 52
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> MPG(ΔNLS) CCP

<400> 52
Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      
Ala Trp Ser Gln Pro Lys Ser Lys Arg Lys Val 
            20                  25          

<210> 53
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> PEP-1 CCP

<400> 53
Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      
Lys Lys Arg Lys Val 
            20      

<210> 54
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> PEP-2 CCP

<400> 54
Lys Glu Thr Trp Phe Glu Thr Trp Phe Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      
Lys Lys Arg Lys Val 
            20      

<210> 55
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> MP1 (linker: m-benzyl)

<400> 55
Cys Thr Leu Lys Cys Lys Leu Ile 
1               5               

<210> 56
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> MP2 (linker: m-benzyl)

<400> 56
Ala Cys Thr Leu Lys Cys Lys Leu Ile 
1               5                   

<210> 57
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> MP3 (linker: m-benzyl)

<400> 57
Ala Cys Leu Lys Glu Cys Leu Ile 
1               5               

<210> 58
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> MP4 (linker: m-benzyl)

<400> 58
Ala Thr Leu Lys Cys Lys Leu Ile Cys 
1               5                   

<210> 59
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> MP5 (linker: m-benzyl)

<400> 59
Ala Thr Leu Lys Glu Cys Leu Ile Ala Cys 
1               5                   10  

<210> 60
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> MP6 (linker: m-benzyl)

<400> 60
Cys Ala Thr Leu Cys Glu Lys Leu Ile 
1               5                   

<210> 61
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> MP7 (linker: p-tetrafluorophenyl)

<400> 61
Cys Thr Leu Lys Cys Lys Leu Ile 
1               5               

<210> 62
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> MP8 (linker: o-benzyl)

<400> 62
Cys Thr Leu Lys Cys Lys Leu Ile 
1               5               

<210> 63
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> MP9 (linker: p-benzyl)

<400> 63
Cys Thr Leu Lys Cys Lys Leu Ile 
1               5               

<210> 64
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> MOD_RES
<222> 1
<223> amino acid residue 1 acetylated ACETYLATION

<220> 
<223> MP10 (linker: Lactam bridge K1-D5)

<400> 64
Lys Thr Leu Lys Asp Lys Leu Ile 
1               5               

<210> 65
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> MP11 (linker: Lactam bridge Nter-E5)

<400> 65
Ala Thr Leu Lys Glu Lys Leu Ile 
1               5               

<210> 66
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> MP12 (linker: Lactam bridge K6-Cter)

<400> 66
Ala Thr Leu Lys Glu Lys Leu Ile 
1               5               

<210> 67
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CT-44 (linker: p-tetrafluorophenyl)

<220> 
<221> VARIANT
<222> 3
<223> X represents mlL (γ-methyl-L-leucine)

<400> 67
Cys Thr Xaa Lys Cys Lys Leu Ile 
1               5               

<210> 68
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CT-45 (linker: p-tetrafluorophenyl)

<220> 
<221> VARIANT
<222> 7
<223> X represents cpA (cyclopropyl-L-alanine)

<400> 68
Cys Thr Leu Lys Cys Lys Xaa Ile 
1               5               

