                         SEQUENCE LISTING

<110>  The Hospital for Sick Children
 
<120>  DETECTION OF BIOMARKERS ASSOCIATED WITH BRUGADA SYNDROME

<130>  H8313075PCT

<140>  PCT CA2020/050578
<141>  2020-05-01

<150>  US 62/842124
<151>  2019-05-02

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Cys Asp Asp Glu Glu Thr Thr Ala Leu Val Cys Asp Asn Gly Ser 
1               5                   10                  15      


Gly Leu Val Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
            20                  25                  30          


Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
        35                  40                  45              


Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
    50                  55                  60                  


Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
65                  70                  75                  80  


Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu 
                85                  90                  95      


Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
            100                 105                 110         


Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
        115                 120                 125             


Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
    130                 135                 140                 


Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
145                 150                 155                 160 


Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                165                 170                 175     


Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
            180                 185                 190         


Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
        195                 200                 205             


Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
    210                 215                 220                 


Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
225                 230                 235                 240 


Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                245                 250                 255     


Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
            260                 265                 270         


Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
        275                 280                 285             


Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Leu Ser Gly Gly 
    290                 295                 300                 


Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
305                 310                 315                 320 


Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                325                 330                 335     


Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
            340                 345                 350         


Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ala Gly 
        355                 360                 365             


Pro Ser Ile Val His Arg Lys Cys Phe 
    370                 375         


<210>  2
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Cys Asp Glu Asp Glu Thr Thr Ala Leu Val Cys Asp Asn Gly Ser 
1               5                   10                  15      


Gly Leu Val Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
            20                  25                  30          


Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
        35                  40                  45              


Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
    50                  55                  60                  


Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
65                  70                  75                  80  


Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu 
                85                  90                  95      


Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
            100                 105                 110         


Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
        115                 120                 125             


Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
    130                 135                 140                 


Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
145                 150                 155                 160 


Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                165                 170                 175     


Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
            180                 185                 190         


Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
        195                 200                 205             


Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
    210                 215                 220                 


Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
225                 230                 235                 240 


Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                245                 250                 255     


Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
            260                 265                 270         


Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
        275                 280                 285             


Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Met Ser Gly Gly 
    290                 295                 300                 


Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
305                 310                 315                 320 


Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                325                 330                 335     


Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
            340                 345                 350         


Thr Phe Gln Gln Met Trp Ile Thr Lys Gln Glu Tyr Asp Glu Ala Gly 
        355                 360                 365             


Pro Ser Ile Val His Arg Lys Cys Phe 
    370                 375         


<210>  3
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Thr Thr Cys Ser Arg Gln Phe Thr Ser Ser Ser Ser Met Lys Gly 
1               5                   10                  15      


Ser Cys Gly Ile Gly Gly Gly Ile Gly Gly Gly Ser Ser Arg Ile Ser 
            20                  25                  30          


Ser Val Leu Ala Gly Gly Ser Cys Arg Ala Pro Ser Thr Tyr Gly Gly 
        35                  40                  45              


Gly Leu Ser Val Ser Ser Ser Arg Phe Ser Ser Gly Gly Ala Cys Gly 
    50                  55                  60                  


Leu Gly Gly Gly Tyr Gly Gly Gly Phe Ser Ser Ser Ser Ser Ser Phe 
65                  70                  75                  80  


Gly Ser Gly Phe Gly Gly Gly Tyr Gly Gly Gly Leu Gly Ala Gly Leu 
                85                  90                  95      


Gly Gly Gly Phe Gly Gly Gly Phe Ala Gly Gly Asp Gly Leu Leu Val 
            100                 105                 110         


Gly Ser Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser 
        115                 120                 125             


Tyr Leu Asp Lys Val Arg Ala Leu Glu Glu Ala Asn Ala Asp Leu Glu 
    130                 135                 140                 


Val Lys Ile Arg Asp Trp Tyr Gln Arg Gln Arg Pro Ala Glu Ile Lys 
145                 150                 155                 160 


Asp Tyr Ser Pro Tyr Phe Lys Thr Ile Glu Asp Leu Arg Asn Lys Ile 
                165                 170                 175     


Leu Thr Ala Thr Val Asp Asn Ala Asn Val Leu Leu Gln Ile Asp Asn 
            180                 185                 190         


Ala Arg Leu Ala Ala Asp Asp Phe Arg Thr Lys Tyr Glu Thr Glu Leu 
        195                 200                 205             


Asn Leu Arg Met Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Val 
    210                 215                 220                 


Leu Asp Glu Leu Thr Leu Ala Arg Ala Asp Leu Glu Met Gln Ile Glu 
225                 230                 235                 240 


Ser Leu Lys Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu Glu Glu 
                245                 250                 255     


Met Asn Ala Leu Arg Gly Gln Val Gly Gly Asp Val Asn Val Glu Met 
            260                 265                 270         


Asp Ala Ala Pro Gly Val Asp Leu Ser Arg Ile Leu Asn Glu Met Arg 
        275                 280                 285             


Asp Gln Tyr Glu Lys Met Ala Glu Lys Asn Arg Lys Asp Ala Glu Glu 
    290                 295                 300                 


Trp Phe Phe Thr Lys Thr Glu Glu Leu Asn Arg Glu Val Ala Thr Asn 
305                 310                 315                 320 


Ser Glu Leu Val Gln Ser Gly Lys Ser Glu Ile Ser Glu Leu Arg Arg 
                325                 330                 335     


Thr Met Gln Asn Leu Glu Ile Glu Leu Gln Ser Gln Leu Ser Met Lys 
            340                 345                 350         


Ala Ser Leu Glu Asn Ser Leu Glu Glu Thr Lys Gly Arg Tyr Cys Met 
        355                 360                 365             


Gln Leu Ala Gln Ile Gln Glu Met Ile Gly Ser Val Glu Glu Gln Leu 
    370                 375                 380                 


Ala Gln Leu Arg Cys Glu Met Glu Gln Gln Asn Gln Glu Tyr Lys Ile 
385                 390                 395                 400 


Leu Leu Asp Val Lys Thr Arg Leu Glu Gln Glu Ile Ala Thr Tyr Arg 
                405                 410                 415     


Arg Leu Leu Glu Gly Glu Asp Ala His Leu Ser Ser Ser Gln Phe Ser 
            420                 425                 430         


Ser Gly Ser Gln Ser Ser Arg Asp Val Thr Ser Ser Ser Arg Gln Ile 
        435                 440                 445             


Arg Thr Lys Val Met Asp Val His Asp Gly Lys Val Val Ser Thr His 
    450                 455                 460                 


Glu Gln Val Leu Arg Thr Lys Asn 
465                 470         


<210>  4
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Asp Trp Ser Ala Leu Gly Lys Leu Leu Asp Lys Val Gln Ala 
1               5                   10                  15      


Tyr Ser Thr Ala Gly Gly Lys Val Trp Leu Ser Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Ile Leu Leu Leu Gly Thr Ala Val Glu Ser Ala Trp Gly Asp Glu 
        35                  40                  45              


Gln Ser Ala Phe Arg Cys Asn Thr Gln Gln Pro Gly Cys Glu Asn Val 
    50                  55                  60                  


Cys Tyr Asp Lys Ser Phe Pro Ile Ser His Val Arg Phe Trp Val Leu 
65                  70                  75                  80  


Gln Ile Ile Phe Val Ser Val Pro Thr Leu Leu Tyr Leu Ala His Val 
                85                  90                  95      


Phe Tyr Val Met Arg Lys Glu Glu Lys Leu Asn Lys Lys Glu Glu Glu 
            100                 105                 110         


Leu Lys Val Ala Gln Thr Asp Gly Val Asn Val Asp Met His Leu Lys 
        115                 120                 125             


Gln Ile Glu Ile Lys Lys Phe Lys Tyr Gly Ile Glu Glu His Gly Lys 
    130                 135                 140                 


Val Lys Met Arg Gly Gly Leu Leu Arg Thr Tyr Ile Ile Ser Ile Leu 
145                 150                 155                 160 


Phe Lys Ser Ile Phe Glu Val Ala Phe Leu Leu Ile Gln Trp Tyr Ile 
                165                 170                 175     


Tyr Gly Phe Ser Leu Ser Ala Val Tyr Thr Cys Lys Arg Asp Pro Cys 
            180                 185                 190         


Pro His Gln Val Asp Cys Phe Leu Ser Arg Pro Thr Glu Lys Thr Ile 
        195                 200                 205             


Phe Ile Ile Phe Met Leu Val Val Ser Leu Val Ser Leu Ala Leu Asn 
    210                 215                 220                 


Ile Ile Glu Leu Phe Tyr Val Phe Phe Lys Gly Val Lys Asp Arg Val 
225                 230                 235                 240 


Lys Gly Lys Ser Asp Pro Tyr His Ala Thr Ser Gly Ala Leu Ser Pro 
                245                 250                 255     


Ala Lys Asp Cys Gly Ser Gln Lys Tyr Ala Tyr Phe Asn Gly Cys Ser 
            260                 265                 270         


Ser Pro Thr Ala Pro Leu Ser Pro Met Ser Pro Pro Gly Tyr Lys Leu 
        275                 280                 285             


Val Thr Gly Asp Arg Asn Asn Ser Ser Cys Arg Asn Tyr Asn Lys Gln 
    290                 295                 300                 


Ala Ser Glu Gln Asn Trp Ala Asn Tyr Ser Ala Glu Gln Asn Arg Met 
305                 310                 315                 320 


Gly Gln Ala Gly Ser Thr Ile Ser Asn Ser His Ala Gln Pro Phe Asp 
                325                 330                 335     


Phe Pro Asp Asp Asn Gln Asn Ser Lys Lys Leu Ala Ala Gly His Glu 
            340                 345                 350         


Leu Gln Pro Leu Ala Ile Val Asp Gln Arg Pro Ser Ser Arg Ala Ser 
        355                 360                 365             


Ser Arg Ala Ser Ser Arg Pro Arg Pro Asp Asp Leu Glu Ile 
    370                 375                 380         


