                               SEQUENCE LISTING

<110> ALETA BIOTHERAPEUTICS INC.
 
<120> COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER

<130> 2012106-0090

<140> PCT/US2020/029967
<141> 2020-04-24

<150> 62/839,376
<151> 2019-04-26

<160> 390   

<170> PatentIn version 3.5

<210> 1
<211> 816
<212> DNA
<213> Homo sapiens

<400> 1
cccgaggaac ctctagtggt gaaggtggaa gagggagata acgctgtgct gcagtgcctc       60

aaggggacct cagatggccc cactcagcag ctgacctggt ctcgggagtc cccgcttaaa      120

cccttcttaa aactcagcct ggggctgcca ggcctgggaa tccacatgag gcccctggcc      180

atctggcttt tcatcttcaa cgtctctcaa cagatggggg gcttctacct gtgccagccg      240

gggcccccct ctgagaaggc ctggcagcct ggctggacag tcaatgtgga gggcagcggg      300

gagctgttcc ggtggaatgt ttcggaccta ggtggcctgg gctgtggcct gaagaacagg      360

tcctcagagg gccccagctc cccttccggg aagctcatga gccccaagct gtatgtgtgg      420

gccaaagacc gccctgagat ctgggaggga gagcctccgt gtctcccacc gagggacagc      480

ctgaaccaga gcctcagcca ggacctcacc atggcccctg gctccacact ctggctgtcc      540

tgtggggtac cccctgactc tgtgtccagg ggccccctct cctggaccca tgtgcacccc      600

aaggggccta agtcattgct gagcctagag ctgaaggacg atcgcccggc cagagatatg      660

tgggtaatgg agacgggtct gttgttgccc cgggccacag ctcaagacgc tggaaagtat      720

tattgtcacc gtggcaacct gaccatgtca ttccacctgg agatcactgc tcggccagta      780

ctatggcact ggctgctgag gactggtggc tggaag                                816


<210> 2
<211> 272
<212> PRT
<213> Homo sapiens

<400> 2
Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val 
1               5                   10                  15      


Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr 
            20                  25                  30          


Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly 
        35                  40                  45              


Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe 
    50                  55                  60                  


Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val 
                85                  90                  95      


Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly 
            100                 105                 110         


Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro 
        115                 120                 125             


Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg 
    130                 135                 140                 


Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser 
145                 150                 155                 160 


Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr 
                165                 170                 175     


Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro 
            180                 185                 190         


Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser 
        195                 200                 205             


Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu 
    210                 215                 220                 


Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr 
225                 230                 235                 240 


Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr 
                245                 250                 255     


Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys 
            260                 265                 270         


<210> 3

<400> 3
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<210> 4

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<400> 5
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<400> 6
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<400> 7
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<400> 8
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<210> 9

<400> 9
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<210> 10

<400> 10
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<210> 11

<400> 11
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<210> 12

<400> 12
000


<210> 13

<400> 13
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<210> 14

<400> 14
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<210> 15

<400> 15
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<210> 16

<400> 16
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<210> 17

<400> 17
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<210> 18

<400> 18
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<210> 19

<400> 19
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<210> 20

<400> 20
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<210> 21

<400> 21
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<210> 22

<400> 22
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<400> 23
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<400> 24
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<400> 25
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<210> 26

<400> 26
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<210> 27

<400> 27
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<210> 28

<400> 28
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<400> 29
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<400> 30
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<210> 31

<400> 31
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<400> 32
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<400> 33
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<400> 34
000


<210> 35

<400> 35
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<210> 36

<400> 36
000


<210> 37

<400> 37
000


<210> 38

<400> 38
000


<210> 39

<400> 39
000


<210> 40

<400> 40
000


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<400> 41
000


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<400> 42
000


<210> 43

<400> 43
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<210> 44

<400> 44
000


<210> 45

<400> 45
000


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<400> 46
000


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<400> 47
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<210> 48

<400> 48
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<400> 49
000


<210> 50

<400> 50
000


<210> 51

<400> 51
000


<210> 52

<400> 52
000


<210> 53

<400> 53
000


<210> 54

<400> 54
000


<210> 55

<400> 55
000


<210> 56

<400> 56
000


<210> 57

<400> 57
000


<210> 58

<400> 58
000


<210> 59

<400> 59
000


<210> 60

<400> 60
000


<210> 61

<400> 61
000


<210> 62

<400> 62
000


<210> 63

<400> 63
000


<210> 64

<400> 64
000


<210> 65

<400> 65
000


<210> 66

<400> 66
000


<210> 67

<400> 67
000


<210> 68

<400> 68
000


<210> 69

<400> 69
000


<210> 70

<400> 70
000


<210> 71

<400> 71
000


<210> 72

<400> 72
000


<210> 73

<400> 73
000


<210> 74

<400> 74
000


<210> 75

<400> 75
000


<210> 76

<400> 76
000


<210> 77

<400> 77
000


<210> 78

<400> 78
000


<210> 79

<400> 79
000


<210> 80

<400> 80
000


<210> 81

<400> 81
000


<210> 82

<400> 82
000


<210> 83

<400> 83
000


<210> 84

<400> 84
000


<210> 85

<400> 85
000


<210> 86

<400> 86
000


<210> 87

<400> 87
000


<210> 88

<400> 88
000


<210> 89

<400> 89
000


<210> 90

<400> 90
000


<210> 91

<400> 91
000


<210> 92

<400> 92
000


<210> 93

<400> 93
000


<210> 94

<400> 94
000


<210> 95

<400> 95
000


<210> 96

<400> 96
000


<210> 97

<400> 97
000


<210> 98

<400> 98
000


<210> 99

<400> 99
000


<210> 100

<400> 100
000


<210> 101

<400> 101
000


<210> 102

<400> 102
000


<210> 103

<400> 103
000


<210> 104

<400> 104
000


<210> 105

<400> 105
000


<210> 106

<400> 106
000


<210> 107

<400> 107
000


<210> 108

<400> 108
000


<210> 109

<400> 109
000


<210> 110

<400> 110
000


<210> 111

<400> 111
000


<210> 112

<400> 112
000


<210> 113

<400> 113
000


<210> 114

<400> 114
000


<210> 115

<400> 115
000


<210> 116

<400> 116
000


<210> 117

<400> 117
000


<210> 118

<400> 118
000


<210> 119

<400> 119
000


<210> 120

<400> 120
000


<210> 121

<400> 121
000


<210> 122

<400> 122
000


<210> 123

<400> 123
000


<210> 124

<400> 124
000


<210> 125

<400> 125
000


<210> 126

<400> 126
000


<210> 127

<400> 127
000


<210> 128

<400> 128
000


<210> 129

<400> 129
000


<210> 130

<400> 130
000


<210> 131

<400> 131
000


<210> 132

<400> 132
000


<210> 133

<400> 133
000


<210> 134

<400> 134
000


<210> 135

<400> 135
000


<210> 136

<400> 136
000


<210> 137

<400> 137
000


<210> 138

<400> 138
000


<210> 139

<400> 139
000


<210> 140

<400> 140
000


<210> 141

<400> 141
000


<210> 142

<400> 142
000


<210> 143

<400> 143
000


<210> 144

<400> 144
000


<210> 145

<400> 145
000


<210> 146

<400> 146
000


<210> 147

<400> 147
000


<210> 148

<400> 148
000


<210> 149

<400> 149
000


<210> 150

<400> 150
000


<210> 151

<400> 151
000


<210> 152

<400> 152
000


<210> 153

<400> 153
000


<210> 154

<400> 154
000


<210> 155

<400> 155
000


<210> 156

<400> 156
000


<210> 157

<400> 157
000


<210> 158

<400> 158
000


<210> 159

<400> 159
000


<210> 160

<400> 160
000


<210> 161

<400> 161
000


<210> 162

<400> 162
000


<210> 163

<400> 163
000


<210> 164

<400> 164
000


<210> 165

<400> 165
000


<210> 166

<400> 166
000


<210> 167

<400> 167
000


<210> 168

<400> 168
000


<210> 169

<400> 169
000


<210> 170

<400> 170
000


<210> 171

<400> 171
000


<210> 172

<400> 172
000


<210> 173

<400> 173
000


<210> 174

<400> 174
000


<210> 175

<400> 175
000


<210> 176

<400> 176
000


<210> 177

<400> 177
000


<210> 178

<400> 178
000


<210> 179

<400> 179
000


<210> 180

<400> 180
000


<210> 181

<400> 181
000


<210> 182

<400> 182
000


<210> 183

<400> 183
000


<210> 184

<400> 184
000


<210> 185

<400> 185
000


<210> 186

<400> 186
000


<210> 187

<400> 187
000


<210> 188

<400> 188
000


<210> 189

<400> 189
000


<210> 190

<400> 190
000


<210> 191

<400> 191
000


<210> 192

<400> 192
000


<210> 193

<400> 193
000


<210> 194

<400> 194
000


<210> 195

<400> 195
000


<210> 196

<400> 196
000


<210> 197

<400> 197
000


<210> 198

<400> 198
000


<210> 199

<400> 199
000


<210> 200

<400> 200
000


<210> 201

<400> 201
000


<210> 202

<400> 202
000


<210> 203
<211> 148
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 203
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ala Ile Asn 
            20                  25                  30          


Glu Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              


Glu Leu Val Ala Ala Cys Ala Ser Asp Gly Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Lys Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asp Ala Asn Ser Arg Gly Asn Tyr Tyr Ser Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly Ala Glu 
        115                 120                 125             


Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Ala His His His His His 
    130                 135                 140                 


His Gly Ala Ser 
145             


<210> 204
<211> 148
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 204
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ala Ile Asn 
            20                  25                  30          


Glu Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              


Glu Leu Val Ala Ala Cys Ala Ser Asp Gly Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Lys Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asp Ala Asn Ser Arg Gly Asn Tyr Tyr Ser Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly Ala Glu 
        115                 120                 125             


Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Ala His His His His His 
    130                 135                 140                 


His Gly Ala Ser 
145             


<210> 205
<211> 148
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 205
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ala Ile Asn 
            20                  25                  30          


Glu Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              


Glu Leu Val Ala Ala Cys Ala Ser Asp Gly Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Lys Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asp Ala Asn Ser Arg Gly Asn Tyr Tyr Ser Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly Ala Glu 
        115                 120                 125             


Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Ala His His His His His 
    130                 135                 140                 


His Gly Ala Ser 
145             


<210> 206
<211> 148
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 206
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ala Ile Asn 
            20                  25                  30          


Glu Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              


Glu Leu Val Ala Ala Cys Ala Ser Asp Gly Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Lys Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asp Ala Asn Ser Arg Gly Asn Tyr Tyr Ser Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly Ala Glu 
        115                 120                 125             


Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Ala His His His His His 
    130                 135                 140                 


His Gly Ala Ser 
145             


<210> 207
<211> 148
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 207
Gln Val Gln Leu Gln Gln Phe Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ala Ile Asn 
            20                  25                  30          


Glu Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              


Glu Leu Val Ala Ala Cys Ala Ser Asp Gly Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Lys Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asp Ala Asn Ser Arg Gly Asn Tyr Tyr Ser Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly Ala Glu 
        115                 120                 125             


Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Ala His His His His His 
    130                 135                 140                 


His Gly Ala Ser 
145             


<210> 208
<211> 148
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 208
Gln Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ala Ile Asn 
            20                  25                  30          


Glu Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              


Glu Leu Val Ala Ala Cys Ala Ser Asp Gly Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Lys Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asp Ala Asn Ser Arg Gly Asn Tyr Tyr Ser Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly Ala Glu 
        115                 120                 125             


Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Ala His His His His His 
    130                 135                 140                 


His Gly Ala Ser 
145             


<210> 209
<211> 148
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 209
Gln Val Gln Leu Gln Glu Phe Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ala Ile Asn 
            20                  25                  30          


Glu Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              


Glu Leu Val Ala Ala Cys Ala Ser Asp Gly Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Lys Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asp Ala Asn Ser Arg Gly Asn Tyr Tyr Ser Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly Ala Glu 
        115                 120                 125             


Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Ala His His His His His 
    130                 135                 140                 


His Gly Ala Ser 
145             


<210> 210
<211> 148
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 210
Gln Val Gln Leu Gln Glu Phe Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ala Ile Asn 
            20                  25                  30          


Glu Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              


Glu Leu Val Ala Ala Cys Ala Ser Asp Gly Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Lys Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asp Ala Asn Ser Arg Gly Asn Tyr Tyr Ser Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly Ala Glu 
        115                 120                 125             


Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Ala His His His His His 
    130                 135                 140                 


His Gly Ala Ser 
145             


<210> 211
<211> 148
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 211
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ala Ile Asn 
            20                  25                  30          


Glu Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              


Glu Leu Val Ala Ala Cys Ala Ser Asp Gly Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Lys Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asp Ala Asn Ser Arg Gly Asn Tyr Tyr Ser Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly Ala Glu 
        115                 120                 125             


Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Ala His His His His His 
    130                 135                 140                 


His Gly Ala Ser 
145             


<210> 212
<211> 148
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 212
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Ala Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Ile Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ala Ile Asn 
            20                  25                  30          


Glu Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              


Glu Leu Val Ala Ala Cys Ala Ser Asp Gly Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Lys Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asp Ala Asn Ser Arg Gly Asn Tyr Tyr Ser Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly Ala Glu 
        115                 120                 125             


Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Ala His His His His His 
    130                 135                 140                 


His Gly Ala Ser 
145             


<210> 213
<211> 148
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 213
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ala Ile Asn 
            20                  25                  30          


Glu Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              


Glu Leu Val Ala Ala Cys Ala Ser Asp Gly Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Lys Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asp Ala Asn Ser Arg Gly Asn Tyr Tyr Ser Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly Ala Glu 
        115                 120                 125             


Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Ala His His His His His 
    130                 135                 140                 


His Gly Ala Ser 
145             


<210> 214
<211> 145
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 214
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Val Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Asp Thr Arg Ser Ile Asn 
            20                  25                  30          


Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Cys Ala Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Lys Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Asp 
                85                  90                  95      


Ala Asn Ser Arg Gly Asn Tyr Tyr Ser Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly Ala Glu Gln Lys Leu 
        115                 120                 125             


Ile Ser Glu Glu Asp Leu Gly Ala His His His His His His Gly Ala 
    130                 135                 140                 


Ser 
145 


<210> 215
<211> 145
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 215
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Ile Arg Ser Ile Asn 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Cys Ala Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Lys Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Asp 
                85                  90                  95      


Ala Asn Ser Arg Gly Asn Tyr Tyr Ser Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly Ala Glu Gln Lys Leu 
        115                 120                 125             


Ile Ser Glu Glu Asp Leu Gly Ala His His His His His His Gly Ala 
    130                 135                 140                 


Ser 
145 


<210> 216
<211> 156
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 216
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Asn Ser Gly Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Glu Leu Arg Gly Ser Asp Tyr Tyr Arg Gly Pro Ile Arg Glu 
            100                 105                 110         


Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Ser 
        115                 120                 125             


Gly Pro Gly Gly Gln Gly Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp 
    130                 135                 140                 


Leu Gly Ala His His His His His His Gly Ala Ser 
145                 150                 155     


<210> 217
<211> 156
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 217
Gln Val Gln Leu Gln Glu Ser Gly Gly Ala Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Ser Gly Gly Thr Thr Asp Tyr Ala Thr Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Tyr Arg Leu Arg Ile Thr Val Val Val Thr Pro Asp Glu 
            100                 105                 110         


Tyr His Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Ser 
        115                 120                 125             


Gly Pro Gly Gly Gln Gly Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp 
    130                 135                 140                 


Leu Gly Ala His His His His His His Gly Ala Ser 
145                 150                 155     


<210> 218
<211> 151
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 218
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Trp Asn Gly Gly Gly Thr Tyr Tyr Ala Glu Ser Ile 
    50                  55                  60                  


Val Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Lys Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Lys Leu Val Asp Ser Gly Trp Tyr Ser Ala Tyr Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Thr Ser Gly Pro Gly Gly Gln 
        115                 120                 125             


Gly Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Ala His His 
    130                 135                 140                 


His His His His Gly Ala Ser 
145                 150     


<210> 219
<211> 150
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 219
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ala Thr Ser Asn Val Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Ser Thr Ser Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Asp Trp Ala Thr Glu Gly Tyr Glu Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly 
        115                 120                 125             


Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Ala His His His 
    130                 135                 140                 


His His His Gly Ala Ser 
145                 150 


<210> 220
<211> 144
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 220
Gln Val Gln Leu Gln Ala Phe Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Thr Met Phe Ser Gly Lys 
            20                  25                  30          


Asp Val Asn Trp Leu Arg Gln Ala Pro Gly Lys His Val Glu Val Val 
        35                  40                  45              


Ala Thr Val Ser Ser Asp Gly Gly Thr Asp Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Asn Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Asn Tyr Met Cys His 
                85                  90                  95      


Phe Leu Trp Gly Arg His Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly Ala Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu Gly Ala His His His His His His Gly Ala Ser 
    130                 135                 140                 


<210> 221
<211> 156
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 221
Gln Val Gln Leu Gln Ala Phe Gly Gly Gly Met Val Gln Ala Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asn Asp Ile Ser Gly Ser 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Ala His Leu Gly Ala Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Val Asp Ala Pro Arg Glu Arg Pro Phe Tyr Ile Asp Pro Val Ile 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Arg Asn Lys Met Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Arg Pro Asp Asp Thr Ala Thr Tyr Trp Cys Gly 
                85                  90                  95      


Pro Ser Leu Arg Thr Phe His Gly Arg Glu Trp Tyr Arg Pro Pro Trp 
            100                 105                 110         


Phe Thr Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr Ser 
        115                 120                 125             


Gly Pro Gly Gly Gln Gly Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp 
    130                 135                 140                 


Leu Gly Ala His His His His His His Gly Ala Ser 
145                 150                 155     


<210> 222
<211> 150
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 222
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Met Val 
        35                  40                  45              


Ala Val Val Ser Arg Phe Gly Glu Thr Thr Tyr Thr Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Ile Asn Arg Asn Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Arg Ile Arg Gly Asn Tyr Gly Ser Arg Ile Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly 
        115                 120                 125             


Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Ala His His His 
    130                 135                 140                 


His His His Gly Ala Ser 
145                 150 


<210> 223
<211> 137
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 223
Gln Val Gln Leu Gln Glu Phe Gly Gly Gly Leu Val Gln Leu Gly Gly 
1               5                   10                  15      


Ser Ala Arg Leu Ser Cys Val Val Ser Gly Asn Met Leu Asp Leu Asn 
            20                  25                  30          


Thr Met Ala Trp Tyr Arg Gln Gly Glu Leu Val Ala Ala Leu Gly Ile 
        35                  40                  45              


Ser Thr Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    50                  55                  60                  


Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser 
65                  70                  75                  80  


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Asn Phe Glu Ser 
                85                  90                  95      


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Ser Gly Pro Gly 
            100                 105                 110         


Gly Gln Gly Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Ala 
        115                 120                 125             


His His His His His His Gly Ala Ser 
    130                 135         


<210> 224
<211> 146
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 224
Ala Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Asp Arg Ser Ile Asn 
            20                  25                  30          


Val Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Gly Thr Thr Asn Tyr Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Lys 
                85                  90                  95      


Ala Asp Thr Arg Trp Gly Gly Met Tyr Trp Gly Pro Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly Ala Glu Gln Lys 
        115                 120                 125             


Leu Ile Ser Glu Glu Asp Leu Gly Ala His His His His His His Gly 
    130                 135                 140                 


Ala Ser 
145     


<210> 225
<211> 154
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 225
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Thr Gly Arg Thr Ile Asp Asn Gly 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Ser Gly Gly Ala Thr Phe Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Tyr Arg Phe Thr Ile Ser Arg Asp Asn Val Arg His Thr Leu Asp 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Thr Ile Tyr Phe Cys 
                85                  90                  95      


Ala Ser Arg Arg Gly Val Asp Leu Arg Arg Asn Ser Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Thr Ser Gly Pro 
        115                 120                 125             


Gly Gly Gln Gly Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly 
    130                 135                 140                 


Ala His His His His His His Gly Ala Ser 
145                 150                 


<210> 226

<400> 226
000


<210> 227

<400> 227
000


<210> 228

<400> 228
000


<210> 229

<400> 229
000


<210> 230

<400> 230
000


<210> 231

<400> 231
000


<210> 232

<400> 232
000


<210> 233

<400> 233
000


<210> 234

<400> 234
000


<210> 235

<400> 235
000


<210> 236

<400> 236
000


<210> 237

<400> 237
000


<210> 238

<400> 238
000


<210> 239

<400> 239
000


<210> 240

<400> 240
000


<210> 241

<400> 241
000


<210> 242

<400> 242
000


<210> 243

<400> 243
000


<210> 244

<400> 244
000


<210> 245

<400> 245
000


<210> 246

<400> 246
000


<210> 247

<400> 247
000


<210> 248

<400> 248
000


<210> 249

<400> 249
000


<210> 250

<400> 250
000


<210> 251

<400> 251
000


<210> 252

<400> 252
000


<210> 253

<400> 253
000


<210> 254

<400> 254
000


<210> 255

<400> 255
000


<210> 256

<400> 256
000


<210> 257

<400> 257
000


<210> 258

<400> 258
000


<210> 259

<400> 259
000


<210> 260

<400> 260
000


<210> 261

<400> 261
000


<210> 262

<400> 262
000


<210> 263

<400> 263
000


<210> 264

<400> 264
000


<210> 265

<400> 265
000


<210> 266

<400> 266
000


<210> 267

<400> 267
000


<210> 268

<400> 268
000


<210> 269

<400> 269
000


<210> 270

<400> 270
000


<210> 271

<400> 271
000


<210> 272

<400> 272
000


<210> 273

<400> 273
000


<210> 274

<400> 274
000


<210> 275

<400> 275
000


<210> 276

<400> 276
000


<210> 277

<400> 277
000


<210> 278

<400> 278
000


<210> 279

<400> 279
000


<210> 280

<400> 280
000


<210> 281

<400> 281
000


<210> 282

<400> 282
000


<210> 283

<400> 283
000


<210> 284

<400> 284
000


<210> 285

<400> 285
000


<210> 286

<400> 286
000


<210> 287

<400> 287
000


<210> 288

<400> 288
000


<210> 289

<400> 289
000


<210> 290

<400> 290
000


<210> 291

<400> 291
000


<210> 292

<400> 292
000


<210> 293

<400> 293
000


<210> 294

<400> 294
000


<210> 295

<400> 295
000


<210> 296

<400> 296
000


<210> 297

<400> 297
000


<210> 298

<400> 298
000


<210> 299

<400> 299
000


<210> 300
<211> 1647
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 300
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccaggagga      840

ggtgggtctg gaggtggagg atctggtgga ggtgggtctg gaggaggtgg gtctgacatg      900

gcccaggtgc agctgcagga gagcggcccc ggcctggtga agcccagcga gaccctgagc      960

ctgacctgcg tggtgagcgg cggcagcatc agcagcagca actggtggag ctgggtgagg     1020

cagccccccg gcaagggcct ggagtggatc ggcgagatct accacagcgg cagccccgac     1080

tacaacccca gcctgaagag cagggtgacc atcagcgtgg acaagagcag gaaccagttc     1140

agcctgaagc tgagcagcgt gaccgccgcc gacaccgccg tgtactactg cgccaaggtg     1200

agcaccggcg gcttcttcga ctactggggc cagggcaccc tggtgaccgt gagcagcggc     1260

ggcggcggca gcggcggcgg cggcagcggc ggcggcggca gcgagatcga gctgacccag     1320

agccccagca gcctgagcgc cagcgtgggc gacagggtga ccatcacctg cagggccagc     1380

cagagcatca gcagctacct gaactggtac cagcagaagc ccggcaaggc ccccaagctg     1440

ctgatctacg ccgccagcag cctgcagagc ggcgtgccca gcaggttcag cggcagcggc     1500

agcggcaccg acttcaccct gaccatcagc agcctgcagc ccgaggactt cgccacctac     1560

tactgccagc agagctacag cacccccccc accttcggcc ccggcaccaa ggtggagatc     1620

aagaggaccc accaccacca ccaccac                                         1647


<210> 301
<211> 549
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 301
Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Met Ala Gln Val Gln 
    290                 295                 300                 


Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser 
305                 310                 315                 320 


Leu Thr Cys Val Val Ser Gly Gly Ser Ile Ser Ser Ser Asn Trp Trp 
                325                 330                 335     


Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu 
            340                 345                 350         


Ile Tyr His Ser Gly Ser Pro Asp Tyr Asn Pro Ser Leu Lys Ser Arg 
        355                 360                 365             


Val Thr Ile Ser Val Asp Lys Ser Arg Asn Gln Phe Ser Leu Lys Leu 
    370                 375                 380                 


Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val 
385                 390                 395                 400 


Ser Thr Gly Gly Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                405                 410                 415     


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Glu Ile Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
        435                 440                 445             


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
    450                 455                 460                 


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
465                 470                 475                 480 


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
                485                 490                 495     


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
            500                 505                 510         


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
        515                 520                 525             


Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg Thr His 
    530                 535                 540                 


His His His His His 
545                 


<210> 302
<211> 1377
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 302
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggagcccc tggtggtgaa ggtggaggag ggcgacaccg ccgtgctgcc ctgcctgaag      120

ggcaccagcg acggccccac ccagcagctg acctggagca gggagagccc cctgaagccc      180

ttcctgaagt acagcctggg cgtgcccggc ctgggcgtgc acgtgaggcc cgacgccatc      240

agcgtggtga tcaggaacgt gagccagcag atgggcggct tctacctgtg ccagcccggc      300

ccccccagcg agaaggcctg gcagcccggc tggaccgtga acgtggaggg cagcggcgag      360

ctgttcaggt ggaacgtgag cgacctgggc ggcctgggct gcggcctgaa gaacaggagc      420

agcgagggcc ccagcagccc cagcggcaag ctgatgagcc ccaagctgta cgtgtgggcc      480

aaggacaggc ccgagatctg ggagggcgag cccccctgcc tgccccccag ggacagcctg      540

aaccagagcc tgagccagga cctgaccatg gcccccggca gcaccctgtg gctgagctgc      600

ggcgtgcccc ccgacagcgt gagcaggggc cccctgagct ggacccacgt gcaccccaag      660

ggccccaaga gcctgctgag cctggagctg aaggacgaca ggcccgccag ggagatgatc      720

gtggacgaga ccggcctgct gctgcccagg gccaccgccc aggacgccgg caagtggtac      780

tgcagcaggg gcaacgtgac caccagctac cacctggaga tcaccgccag gcccgtgaag      840

gcccacagcg acctgaggac cggcggctgg aagggaggag gtgggtctgg aggtggagga      900

tctggtggag gtgggtctgg aggaggtgga tcccaggtgc agctgcaagc gtctggggga      960

ggcttggtgc aggctggggg gtctctgaga ctctcctgtg cagcctcagg aagcatcttc     1020

gctattaatg aaatcaatct tatggggtgg taccgccagg ctccagggaa gcagcgcgag     1080

ttggtcgcag cttgtgctag tgatggcaac acatactatg cggactccgt gaagggccga     1140

ttcaccatct ccagagacaa cgccgagaaa acggtgtatc tgcagatgaa caacctgaaa     1200

cctgacgaca cagccgtcta ttactgtgat gcgaattcga gggggaatta ttattcgggc     1260

caggggaccc aggtcaccgt ttcctcaact agtggcccgg gaggccaagg cgcagaacaa     1320

aaactcatct cagaagagga tctgggcgca caccatcacc accatcatgg cgcatct        1377


<210> 303
<211> 459
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 303
Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Thr Ala Val Leu Pro Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Tyr 
    50                  55                  60                  


Ser Leu Gly Val Pro Gly Leu Gly Val His Val Arg Pro Asp Ala Ile 
65                  70                  75                  80  


Ser Val Val Ile Arg Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Glu Met Ile 
225                 230                 235                 240 


Val Asp Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Trp Tyr Cys Ser Arg Gly Asn Val Thr Thr Ser Tyr His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Lys Ala His Ser Asp Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Ala Ser Gly Gly 
305                 310                 315                 320 


Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                325                 330                 335     


Gly Ser Ile Phe Ala Ile Asn Glu Ile Asn Leu Met Gly Trp Tyr Arg 
            340                 345                 350         


Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Cys Ala Ser Asp 
        355                 360                 365             


Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    370                 375                 380                 


Arg Asp Asn Ala Glu Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys 
385                 390                 395                 400 


Pro Asp Asp Thr Ala Val Tyr Tyr Cys Asp Ala Asn Ser Arg Gly Asn 
                405                 410                 415     


Tyr Tyr Ser Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr Ser Gly 
            420                 425                 430         


Pro Gly Gly Gln Gly Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
        435                 440                 445             


Gly Ala His His His His His His Gly Ala Ser 
    450                 455                 


<210> 304
<211> 1290
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 304
atggagtttg ggctgagctg ggttttcctc gttgctcttt ttagaggtgt ccagtgtcag       60

gtgcagctgc aggagtctgg gggaggcttg gtgcaggctg gggggtccct tagactctcc      120

tgtgtagcct ctggaagcat cagaagtatc aatgtcatgg gctggtaccg ccaggctcca      180

gggaagcagc gcgagttggt cgcagcttgt gctagtgatg gcaacacata ctatgcggac      240

tccgtgaagg gccgattcac catctccaga gacaacgccg agaaaacggt gtatctgcag      300

atgaacaacc tgaaacctga cgacacagcc gtctattact gtgatgcgaa ttcgaggggg      360

aattattatt cgggccaggg gacccaggtc accgtttcct caactagtgg cccgggaggc      420

caaggcgcag gaggaggtgg gtctggaggt ggaggatctg gtggaggtgg gtctggagga      480

ggtggatccc ccgaggaacc tctagtggtg aaggtggaag agggagatac cgctgccctg      540

tggtgcctca aggggacctc agatggcccc actcagcagc tgacctggtc tcgggagtcc      600

ccgcttaaac ccttcttaaa atacagcctg ggggtgccag gcctgggagt gcacgtgagg      660

cccgacgcca tcagcgtggt tatccggaac gtctctcaac agatgggggg cttctacctg      720

tgccagccgg ggcccccctc tgagaaggcc tggcagcctg gctggacagt caatgtggag      780

ggcagcgggg agctgttccg gtggaatgtt tcggacctag gtggcctggg ctgtggcctg      840

aagaacaggt cctcagaggg ccccagctcc ccttccggga agctcatgag ccccaagctg      900

tatgtgtggg ccaaagaccg ccctgagatc tgggagggag agcctccgtg tctcccaccg      960

agggacagcc tgaaccagag cctcagccgg gacctcaccg ttgcccctgg ctccacactc     1020

tggctgtcct gtggggtacc ccctgactct gtgtccaggg gccccctctc ctggacccat     1080

gtgcacccca aggggcctaa gtcattgctg agcctagagc tgaaggacga tcgcccggcc     1140

agagatatgt gggtaatggg cacgagcctg atgttgcccc gggccacagc tcaagacgct     1200

ggaaagtggt attgtcaccg tggcaacctg accatgtcat tccacctgga gatcactgct     1260

cggccatcta gacatcatca ccatcaccat                                      1290


<210> 305
<211> 430
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 305
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Ile Arg 
        35                  40                  45              


Ser Ile Asn Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
    50                  55                  60                  


Glu Leu Val Ala Ala Cys Ala Ser Asp Gly Asn Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Lys Thr 
                85                  90                  95      


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Asp Ala Asn Ser Arg Gly Asn Tyr Tyr Ser Gly Gln Gly Thr 
        115                 120                 125             


Gln Val Thr Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly Ala Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
                165                 170                 175     


Thr Ala Ala Leu Trp Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
            180                 185                 190         


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Tyr 
        195                 200                 205             


Ser Leu Gly Val Pro Gly Leu Gly Val His Val Arg Pro Asp Ala Ile 
    210                 215                 220                 


Ser Val Val Ile Arg Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
225                 230                 235                 240 


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
                245                 250                 255     


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
            260                 265                 270         


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
        275                 280                 285             


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
    290                 295                 300                 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
305                 310                 315                 320 


Arg Asp Ser Leu Asn Gln Ser Leu Ser Arg Asp Leu Thr Val Ala Pro 
                325                 330                 335     


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
            340                 345                 350         


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
        355                 360                 365             


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
    370                 375                 380                 


Val Met Gly Thr Ser Leu Met Leu Pro Arg Ala Thr Ala Gln Asp Ala 
385                 390                 395                 400 


Gly Lys Trp Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
                405                 410                 415     


Glu Ile Thr Ala Arg Pro Ser Arg His His His His His His 
            420                 425                 430 


<210> 306
<211> 2085
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 306
atggagtttg ggctgagctg ggttttcctc gttgctcttt ttagaggtgt ccagtgtgac       60

atggcccagg tgcagctgca ggagagcggc cccggcctgg tgaagcccag cgagaccctg      120

agcctgacct gcgtggtgag cggcggcagc atcagcagca gcaactggtg gagctgggtg      180

aggcagcccc ccggcaaggg cctggagtgg atcggcgaga tctaccacag cggcagcccc      240

gactacaacc ccagcctgaa gagcagggtg accatcagcg tggacaagag caggaaccag      300

ttcagcctga agctgagcag cgtgaccgcc gccgacaccg ccgtgtacta ctgcgccaag      360

gtgagcaccg gcggcttctt cgactactgg ggccagggca ccctggtgac cgtgagcagc      420

ggcggcggcg gcagcggcgg cggcggcagc ggcggcggcg gcagcgagat cgagctgacc      480

cagagcccca gcagcctgag cgccagcgtg ggcgacaggg tgaccatcac ctgcagggcc      540

agccagagca tcagcagcta cctgaactgg taccagcaga agcccggcaa ggcccccaag      600

ctgctgatct acgccgccag cagcctgcag agcggcgtgc ccagcaggtt cagcggcagc      660

ggcagcggca ccgacttcac cctgaccatc agcagcctgc agcccgagga cttcgccacc      720

tactactgcc agcagagcta cagcaccccc cccaccttcg gccccggcac caaggtggag      780

atcaagagga ccggcggcgg aggatctggc ggaggtggaa gcggaggcgg aggaagcggt      840

ggcggcggat ctcaggtgca gctgcaggag tctgggggag gcttggtgca ggctgggggg      900

tcccttagac tctcctgtgt agcctctgga agcatcagaa gtatcaatgt catgggctgg      960

taccgccagg ctccagggaa gcagcgcgag ttggtcgcag cttgtgctag tgatggcaac     1020

acatactatg cggactccgt gaagggccga ttcaccatct ccagagacaa cgccgagaaa     1080

acggtgtatc tgcagatgaa caacctgaaa cctgacgaca cagccgtcta ttactgtgat     1140

gcgaattcga gggggaatta ttattcgggc caggggaccc aggtcaccgt ttcctcaact     1200

agtggcccgg gaggccaagg tgcaggagga ggggggtctg ggggtggagg atctggtgga     1260

ggtgggtctg gaggaggtgg atcccccgag gaacctctag tggtgaaggt ggaagaggga     1320

gataccgctg ccctgtggtg cctcaagggg acctcagatg gccccactca gcagctgacc     1380

tggtctcggg agtccccgct taaacccttc ttaaaataca gcctgggggt gccaggcctg     1440

ggagtgcacg tgaggcccga cgccatcagc gtggttatcc ggaacgtctc tcaacagatg     1500

gggggcttct acctgtgcca gccggggccc ccctctgaga aggcctggca gcctggctgg     1560

acagtcaatg tggagggcag cggggagctg ttccggtgga atgtttcgga cctaggtggc     1620

ctgggctgtg gcctgaagaa caggtcctca gagggcccca gctccccttc cgggaagctc     1680

atgagcccca agctgtatgt gtgggccaaa gaccgccctg agatctggga gggagagcct     1740

ccgtgtctcc caccgaggga cagcctgaac cagagcctca gccgggacct caccgttgcc     1800

cctggctcca cactctggct gtcctgtggg gtaccccctg actctgtgtc caggggcccc     1860

ctctcctgga cccatgtgca ccccaagggg cctaagtcat tgctgagcct agagctgaag     1920

gacgatcgcc cggccagaga tatgtgggta atgggcacga gcctgatgtt gccccgggcc     1980

acagctcaag acgctggaaa gtggtattgt caccgtggca acctgaccat gtcattccac     2040

ctggagatca ctgctcggcc atctagacat catcaccatc accat                     2085


<210> 307
<211> 695
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 307
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Asp Met Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Arg Thr Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
        275                 280                 285             


Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu 
    290                 295                 300                 


Ser Cys Val Ala Ser Gly Ser Ile Arg Ser Ile Asn Val Met Gly Trp 
305                 310                 315                 320 


Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Cys Ala 
                325                 330                 335     


Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            340                 345                 350         


Ile Ser Arg Asp Asn Ala Glu Lys Thr Val Tyr Leu Gln Met Asn Asn 
        355                 360                 365             


Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Asp Ala Asn Ser Arg 
    370                 375                 380                 


Gly Asn Tyr Tyr Ser Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr 
385                 390                 395                 400 


Ser Gly Pro Gly Gly Gln Gly Ala Gly Gly Gly Gly Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Glu Glu Pro 
            420                 425                 430         


Leu Val Val Lys Val Glu Glu Gly Asp Thr Ala Ala Leu Trp Cys Leu 
        435                 440                 445             


Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp Ser Arg Glu 
    450                 455                 460                 


Ser Pro Leu Lys Pro Phe Leu Lys Tyr Ser Leu Gly Val Pro Gly Leu 
465                 470                 475                 480 


Gly Val His Val Arg Pro Asp Ala Ile Ser Val Val Ile Arg Asn Val 
                485                 490                 495     


Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly Pro Pro Ser 
            500                 505                 510         


Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu Gly Ser Gly 
        515                 520                 525             


Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu Gly Cys Gly 
    530                 535                 540                 


Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser Gly Lys Leu 
545                 550                 555                 560 


Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro Glu Ile Trp 
                565                 570                 575     


Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser Leu Asn Gln Ser 
            580                 585                 590         


Leu Ser Arg Asp Leu Thr Val Ala Pro Gly Ser Thr Leu Trp Leu Ser 
        595                 600                 605             


Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu Ser Trp Thr 
    610                 615                 620                 


His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu Glu Leu Lys 
625                 630                 635                 640 


Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Gly Thr Ser Leu Met 
                645                 650                 655     


Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Trp Tyr Cys His Arg 
            660                 665                 670         


Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala Arg Pro Ser 
        675                 680                 685             


Arg His His His His His His 
    690                 695 


<210> 308
<211> 3333
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 308
atgaggcttc tggtgcttct ttggggttgc ttgctgttgc ccggttacga agcagacatc       60

cagatgacac agactacatc ctccctgtct gcctctctgg gagacagagt caccatcagt      120

tgcagggcaa gtcaggacat tagtaaatat ttaaattggt atcagcagaa accagatgga      180

actgttaaac tcctgatcta ccatacatca agattacact caggagtccc atcaaggttc      240

agtggcagtg ggtctggaac agattattct ctcaccatta gcaacctgga gcaagaagat      300

attgccactt acttttgcca acaaggtaat acgcttccgt acacgttcgg aggggggact      360

aagttggaaa taacaggagg cggcgggtct ggaggtggag gatctggtgg tggcgggtct      420

ggaggcggcg ggtctgaggt gaaactgcag gagtcaggac ctggcctggt ggcgccctca      480

cagagcctgt ccgtcacatg cactgtctca ggggtctcat tacccgacta tggtgtaagc      540

tggattcgcc agcctccacg aaagggtctg gagtggctgg gagtaatatg gggtagtgaa      600

accacatact acaactcagc tctcaaatcc agactgacca tcatcaagga caactccaag      660

agccaagttt tcttaaaaat gaacagtctg caaactgatg acacagccat ttactactgt      720

gccaaacatt attactacgg tggtagctat gctatggact actggggtca aggaacctca      780

gtcaccgtct cctcagacta caaagacgat gacgacaaga ttgaagttat gtatcctcct      840

ccttacctag acaatgagaa gagcaatgga accattatcc atgtgaaagg gaaacacctt      900

tgtccaagtc ccctatttcc cggaccttct aagccctttt gggtgctggt ggtggttggt      960

ggagtcctgg cttgctatag cttgctagta acagtggcct ttattatttt ctgggtccgc     1020

agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg     1080

cccacccgca agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc     1140

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     1200

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1260

gaactgagag tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac     1320

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1380

cgtggccggg accctgagat ggggggaaag ccgcagagaa ggaagaaccc tcaggaaggc     1440

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1500

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     1560

aaggacacct acgacgccct tcacatgcaa gccctgcccc ctcgccgcgc gaaacgcagc     1620

ggcagcggcg cgaccaactt tagcctgctg aaacaggcgg gcgatgtgga agaaaacccg     1680

ggcccgatgc cacctcctcg cctcctcttc ttcctcctct tcctcacccc catggaagtc     1740

aggcccgagg aacctctagt ggtgaaggtg gaagagggag ataacgctgt gctgcagtgc     1800

ctcaagggga cctcagatgg ccccactcag cagctgacct ggtctcggga gtccccgctt     1860

aaacccttct taaaactcag cctggggctg ccaggcctgg gaatccacat gaggcccctg     1920

gccatctggc ttttcatctt caacgtctct caacagatgg ggggcttcta cctgtgccag     1980

ccggggcccc cctctgagaa ggcctggcag cctggctgga cagtcaatgt ggagggcagc     2040

ggggagctgt tccggtggaa tgtttcggac ctaggtggcc tgggctgtgg cctgaagaac     2100

aggtcctcag agggccccag ctccccttcc gggaagctca tgagccccaa gctgtatgtg     2160

tgggccaaag accgccctga gatctgggag ggagagcctc cgtgtctccc accgagggac     2220

agcctgaacc agagcctcag ccaggacctc accatggccc ctggctccac actctggctg     2280

tcctgtgggg taccccctga ctctgtgtcc cgcggccccc tctcctggac ccatgtgcac     2340

cccaaggggc ctaagtcatt gctgagccta gagctgaagg acgatcgccc ggccagagat     2400

atgtgggtaa tggagacggg tctgttgttg ccccgggcca cagctcaaga cgctggaaag     2460

tattattgtc accgtggcaa cctgaccatg tcattccacc tggagatcac tgctcggcct     2520

ggcggcggcg ggtctggagg tggaggatct ggtggtggcg ggtctggtgg cggcgggtct     2580

gacatggccc aggtgcagct gcaggagagc ggccccggcc tggtgaagcc cagcgagacc     2640

ctgagcctga cctgcgtggt gagcggcggc agcatcagca gcagcaactg gtggagctgg     2700

gtgaggcagc cccccggcaa gggcctggag tggatcggcg agatctacca cagcggcagc     2760

cccgactaca accccagcct gaagagcagg gtgaccatca gcgtggacaa gagcaggaac     2820

cagttcagcc tgaagctgag cagcgtgacc gccgccgaca ccgccgtgta ctactgcgcc     2880

aaggtgagca ccggcggctt cttcgactac tggggccagg gcaccctggt gaccgtgagc     2940

agcggcggcg gcggcagcgg cggcggcggc agcggcggcg gcggcagcga gatcgagctg     3000

acccagagcc ccagcagcct gagcgccagc gtgggcgaca gggtgaccat cacctgcagg     3060

gccagccaga gcatcagcag ctacctgaac tggtaccagc agaagcccgg caaggccccc     3120

aagctgctga tctacgccgc cagcagcctg cagagcggcg tgcccagcag gttcagcggc     3180

agcggcagcg gcaccgactt caccctgacc atcagcagcc tgcagcccga ggacttcgcc     3240

acctactact gccagcagag ctacagcacc ccccccacct tcggccccgg caccaaggtg     3300

gagatcaaga ggacccacca ccaccaccac cac                                  3333


<210> 309
<211> 1111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 309
Met Arg Leu Leu Val Leu Leu Trp Gly Cys Leu Leu Leu Pro Gly Tyr 
1               5                   10                  15      


Glu Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
            20                  25                  30          


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
        35                  40                  45              


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
    50                  55                  60                  


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
                85                  90                  95      


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
            100                 105                 110         


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser 
145                 150                 155                 160 


Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp 
            180                 185                 190         


Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu 
        195                 200                 205             


Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe 
    210                 215                 220                 


Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser Asp Tyr Lys Asp Asp Asp Asp 
            260                 265                 270         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        275                 280                 285             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    290                 295                 300                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
305                 310                 315                 320 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                325                 330                 335     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg 
    370                 375                 380                 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
385                 390                 395                 400 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
                405                 410                 415     


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            420                 425                 430         


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        435                 440                 445             


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    450                 455                 460                 


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
465                 470                 475                 480 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                485                 490                 495     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            500                 505                 510         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        515                 520                 525             


Met Gln Ala Leu Pro Pro Arg Arg Ala Lys Arg Ser Gly Ser Gly Ala 
    530                 535                 540                 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
545                 550                 555                 560 


Gly Pro Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr 
                565                 570                 575     


Pro Met Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu 
            580                 585                 590         


Gly Asp Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro 
        595                 600                 605             


Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu 
    610                 615                 620                 


Lys Leu Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu 
625                 630                 635                 640 


Ala Ile Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe 
                645                 650                 655     


Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly 
            660                 665                 670         


Trp Thr Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val 
        675                 680                 685             


Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu 
    690                 695                 700                 


Gly Pro Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val 
705                 710                 715                 720 


Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu 
                725                 730                 735     


Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met 
            740                 745                 750         


Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser 
        755                 760                 765             


Val Ser Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro 
    770                 775                 780                 


Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp 
785                 790                 795                 800 


Met Trp Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln 
                805                 810                 815     


Asp Ala Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe 
            820                 825                 830         


His Leu Glu Ile Thr Ala Arg Pro Gly Gly Gly Gly Ser Gly Gly Gly 
        835                 840                 845             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Met Ala Gln 
    850                 855                 860                 


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
865                 870                 875                 880 


Leu Ser Leu Thr Cys Val Val Ser Gly Gly Ser Ile Ser Ser Ser Asn 
                885                 890                 895     


Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
            900                 905                 910         


Gly Glu Ile Tyr His Ser Gly Ser Pro Asp Tyr Asn Pro Ser Leu Lys 
        915                 920                 925             


Ser Arg Val Thr Ile Ser Val Asp Lys Ser Arg Asn Gln Phe Ser Leu 
    930                 935                 940                 


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
945                 950                 955                 960 


Lys Val Ser Thr Gly Gly Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
                965                 970                 975     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            980                 985                 990         


Gly Gly Gly Ser Glu Ile Glu Leu  Thr Gln Ser Pro Ser  Ser Leu Ser 
        995                 1000                 1005             


Ala Ser  Val Gly Asp Arg Val  Thr Ile Thr Cys Arg  Ala Ser Gln 
    1010                 1015                 1020             


Ser Ile  Ser Ser Tyr Leu Asn  Trp Tyr Gln Gln Lys  Pro Gly Lys 
    1025                 1030                 1035             


Ala Pro  Lys Leu Leu Ile Tyr  Ala Ala Ser Ser Leu  Gln Ser Gly 
    1040                 1045                 1050             


Val Pro  Ser Arg Phe Ser Gly  Ser Gly Ser Gly Thr  Asp Phe Thr 
    1055                 1060                 1065             


Leu Thr  Ile Ser Ser Leu Gln  Pro Glu Asp Phe Ala  Thr Tyr Tyr 
    1070                 1075                 1080             


Cys Gln  Gln Ser Tyr Ser Thr  Pro Pro Thr Phe Gly  Pro Gly Thr 
    1085                 1090                 1095             


Lys Val  Glu Ile Lys Arg Thr  His His His His His  His 
    1100                 1105                 1110     


<210> 310
<211> 3771
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 310
atgaggcttc tggtgcttct ttggggttgc ttgctgttgc ccggttacga agcagacatc       60

cagatgacac agactacatc ctccctgtct gcctctctgg gagacagagt caccatcagt      120

tgcagggcaa gtcaggacat tagtaaatat ttaaattggt atcagcagaa accagatgga      180

actgttaaac tcctgatcta ccatacatca agattacact caggagtccc atcaaggttc      240

agtggcagtg ggtctggaac agattattct ctcaccatta gcaacctgga gcaagaagat      300

attgccactt acttttgcca acaaggtaat acgcttccgt acacgttcgg aggggggact      360

aagttggaaa taacaggagg cggcgggtct ggaggtggag gatctggtgg tggcgggtct      420

ggaggcggcg ggtctgaggt gaaactgcag gagtcaggac ctggcctggt ggcgccctca      480

cagagcctgt ccgtcacatg cactgtctca ggggtctcat tacccgacta tggtgtaagc      540

tggattcgcc agcctccacg aaagggtctg gagtggctgg gagtaatatg gggtagtgaa      600

accacatact acaactcagc tctcaaatcc agactgacca tcatcaagga caactccaag      660

agccaagttt tcttaaaaat gaacagtctg caaactgatg acacagccat ttactactgt      720

gccaaacatt attactacgg tggtagctat gctatggact actggggtca aggaacctca      780

gtcaccgtct cctcagacta caaagacgat gacgacaaga ttgaagttat gtatcctcct      840

ccttacctag acaatgagaa gagcaatgga accattatcc atgtgaaagg gaaacacctt      900

tgtccaagtc ccctatttcc cggaccttct aagccctttt gggtgctggt ggtggttggt      960

ggagtcctgg cttgctatag cttgctagta acagtggcct ttattatttt ctgggtccgc     1020

agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg     1080

cccacccgca agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc     1140

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     1200

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1260

gaactgagag tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac     1320

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1380

cgtggccggg accctgagat ggggggaaag ccgcagagaa ggaagaaccc tcaggaaggc     1440

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1500

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     1560

aaggacacct acgacgccct tcacatgcaa gccctgcccc ctcgccgcgc gaaacgcagc     1620

ggcagcggcg cgaccaactt tagcctgctg aaacaggcgg gcgatgtgga agaaaacccg     1680

ggcccgatgg agtttgggct gagctgggtt ttcctcgttg ctctttttag aggtgtccag     1740

tgtgacatgg cccaggtgca gctgcaggag agcggccccg gcctggtgaa gcccagcgag     1800

accctgagcc tgacctgcgt ggtgagcggc ggcagcatca gcagcagcaa ctggtggagc     1860

tgggtgaggc agccccccgg caagggcctg gagtggatcg gcgagatcta ccacagcggc     1920

agccccgact acaaccccag cctgaagagc agggtgacca tcagcgtgga caagagcagg     1980

aaccagttca gcctgaagct gagcagcgtg accgccgccg acaccgccgt gtactactgc     2040

gccaaggtga gcaccggcgg cttcttcgac tactggggcc agggcaccct ggtgaccgtg     2100

agcagcggcg gcggcggcag cggcggcggc ggcagcggcg gcggcggcag cgagatcgag     2160

ctgacccaga gccccagcag cctgagcgcc agcgtgggcg acagggtgac catcacctgc     2220

agggccagcc agagcatcag cagctacctg aactggtacc agcagaagcc cggcaaggcc     2280

cccaagctgc tgatctacgc cgccagcagc ctgcagagcg gcgtgcccag caggttcagc     2340

ggcagcggca gcggcaccga cttcaccctg accatcagca gcctgcagcc cgaggacttc     2400

gccacctact actgccagca gagctacagc acccccccca ccttcggccc cggcaccaag     2460

gtggagatca agaggaccgg cggcggagga tctggcggag gtggaagcgg aggcggagga     2520

agcggtggcg gcggatctca ggtgcagctg caggagtctg ggggaggctt ggtgcaggct     2580

ggggggtccc ttagactctc ctgtgtagcc tctggaagca tcagaagtat caatgtcatg     2640

ggctggtacc gccaggctcc agggaagcag cgcgagttgg tcgcagcttg tgctagtgat     2700

ggcaacacat actatgcgga ctccgtgaag ggccgattca ccatctccag agacaacgcc     2760

gagaaaacgg tgtatctgca gatgaacaac ctgaaacctg acgacacagc cgtctattac     2820

tgtgatgcga attcgagggg gaattattat tcgggccagg ggacccaggt caccgtttcc     2880

tcaactagtg gcccgggagg ccaaggtgca ggaggagggg ggtctggggg tggaggatct     2940

ggtggaggtg ggtctggagg aggtggatcc cccgaggaac ctctagtggt gaaggtggaa     3000

gagggagata ccgctgccct gtggtgcctc aaggggacct cagatggccc cactcagcag     3060

ctgacctggt ctcgggagtc cccgcttaaa cccttcttaa aatacagcct gggggtgcca     3120

ggcctgggag tgcacgtgag gcccgacgcc atcagcgtgg ttatccggaa cgtctctcaa     3180

cagatggggg gcttctacct gtgccagccg gggcccccct ctgagaaggc ctggcagcct     3240

ggctggacag tcaatgtgga gggcagcggg gagctgttcc ggtggaatgt ttcggaccta     3300

ggtggcctgg gctgtggcct gaagaacagg tcctcagagg gccccagctc cccttccggg     3360

aagctcatga gccccaagct gtatgtgtgg gccaaagacc gccctgagat ctgggaggga     3420

gagcctccgt gtctcccacc gagggacagc ctgaaccaga gcctcagccg ggacctcacc     3480

gttgcccctg gctccacact ctggctgtcc tgtggggtac cccctgactc tgtgtccagg     3540

ggccccctct cctggaccca tgtgcacccc aaggggccta agtcattgct gagcctagag     3600

ctgaaggacg atcgcccggc cagagatatg tgggtaatgg gcacgagcct gatgttgccc     3660

cgggccacag ctcaagacgc tggaaagtgg tattgtcacc gtggcaacct gaccatgtca     3720

ttccacctgg agatcactgc tcggccatct agacatcatc accatcacca t              3771


<210> 311
<211> 1257
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 311
Met Arg Leu Leu Val Leu Leu Trp Gly Cys Leu Leu Leu Pro Gly Tyr 
1               5                   10                  15      


Glu Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
            20                  25                  30          


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
        35                  40                  45              


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
    50                  55                  60                  


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
                85                  90                  95      


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
            100                 105                 110         


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser 
145                 150                 155                 160 


Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp 
            180                 185                 190         


Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu 
        195                 200                 205             


Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe 
    210                 215                 220                 


Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser Asp Tyr Lys Asp Asp Asp Asp 
            260                 265                 270         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        275                 280                 285             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    290                 295                 300                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
305                 310                 315                 320 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                325                 330                 335     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg 
    370                 375                 380                 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
385                 390                 395                 400 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
                405                 410                 415     


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            420                 425                 430         


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        435                 440                 445             


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    450                 455                 460                 


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
465                 470                 475                 480 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                485                 490                 495     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            500                 505                 510         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        515                 520                 525             


Met Gln Ala Leu Pro Pro Arg Arg Ala Lys Arg Ser Gly Ser Gly Ala 
    530                 535                 540                 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
545                 550                 555                 560 


Gly Pro Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe 
                565                 570                 575     


Arg Gly Val Gln Cys Asp Met Ala Gln Val Gln Leu Gln Glu Ser Gly 
            580                 585                 590         


Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val 
        595                 600                 605             


Ser Gly Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln 
    610                 615                 620                 


Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly 
625                 630                 635                 640 


Ser Pro Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val 
                645                 650                 655     


Asp Lys Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala 
            660                 665                 670         


Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe 
        675                 680                 685             


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    690                 695                 700                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu 
705                 710                 715                 720 


Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
                725                 730                 735     


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
            740                 745                 750         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
        755                 760                 765             


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    770                 775                 780                 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
785                 790                 795                 800 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly 
                805                 810                 815     


Pro Gly Thr Lys Val Glu Ile Lys Arg Thr Gly Gly Gly Gly Ser Gly 
            820                 825                 830         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        835                 840                 845             


Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu 
    850                 855                 860                 


Arg Leu Ser Cys Val Ala Ser Gly Ser Ile Arg Ser Ile Asn Val Met 
865                 870                 875                 880 


Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ala 
                885                 890                 895     


Cys Ala Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            900                 905                 910         


Phe Thr Ile Ser Arg Asp Asn Ala Glu Lys Thr Val Tyr Leu Gln Met 
        915                 920                 925             


Asn Asn Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Asp Ala Asn 
    930                 935                 940                 


Ser Arg Gly Asn Tyr Tyr Ser Gly Gln Gly Thr Gln Val Thr Val Ser 
945                 950                 955                 960 


Ser Thr Ser Gly Pro Gly Gly Gln Gly Ala Gly Gly Gly Gly Ser Gly 
                965                 970                 975     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Glu 
            980                 985                 990         


Glu Pro Leu Val Val Lys Val Glu  Glu Gly Asp Thr Ala  Ala Leu Trp 
        995                 1000                 1005             


Cys Leu  Lys Gly Thr Ser Asp  Gly Pro Thr Gln Gln  Leu Thr Trp 
    1010                 1015                 1020             


Ser Arg  Glu Ser Pro Leu Lys  Pro Phe Leu Lys Tyr  Ser Leu Gly 
    1025                 1030                 1035             


Val Pro  Gly Leu Gly Val His  Val Arg Pro Asp Ala  Ile Ser Val 
    1040                 1045                 1050             


Val Ile  Arg Asn Val Ser Gln  Gln Met Gly Gly Phe  Tyr Leu Cys 
    1055                 1060                 1065             


Gln Pro  Gly Pro Pro Ser Glu  Lys Ala Trp Gln Pro  Gly Trp Thr 
    1070                 1075                 1080             


Val Asn  Val Glu Gly Ser Gly  Glu Leu Phe Arg Trp  Asn Val Ser 
    1085                 1090                 1095             


Asp Leu  Gly Gly Leu Gly Cys  Gly Leu Lys Asn Arg  Ser Ser Glu 
    1100                 1105                 1110             


Gly Pro  Ser Ser Pro Ser Gly  Lys Leu Met Ser Pro  Lys Leu Tyr 
    1115                 1120                 1125             


Val Trp  Ala Lys Asp Arg Pro  Glu Ile Trp Glu Gly  Glu Pro Pro 
    1130                 1135                 1140             


Cys Leu  Pro Pro Arg Asp Ser  Leu Asn Gln Ser Leu  Ser Arg Asp 
    1145                 1150                 1155             


Leu Thr  Val Ala Pro Gly Ser  Thr Leu Trp Leu Ser  Cys Gly Val 
    1160                 1165                 1170             


Pro Pro  Asp Ser Val Ser Arg  Gly Pro Leu Ser Trp  Thr His Val 
    1175                 1180                 1185             


His Pro  Lys Gly Pro Lys Ser  Leu Leu Ser Leu Glu  Leu Lys Asp 
    1190                 1195                 1200             


Asp Arg  Pro Ala Arg Asp Met  Trp Val Met Gly Thr  Ser Leu Met 
    1205                 1210                 1215             


Leu Pro  Arg Ala Thr Ala Gln  Asp Ala Gly Lys Trp  Tyr Cys His 
    1220                 1225                 1230             


Arg Gly  Asn Leu Thr Met Ser  Phe His Leu Glu Ile  Thr Ala Arg 
    1235                 1240                 1245             


Pro Ser  Arg His His His His  His His 
    1250                 1255         


<210> 312
<211> 3054
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 312
atgaggcttc tggtgcttct ttggggttgc ttgctgttgc ccggttacga agcagacatc       60

cagatgacac agactacatc ctccctgtct gcctctctgg gagacagagt caccatcagt      120

tgcagggcaa gtcaggacat tagtaaatat ttaaattggt atcagcagaa accagatgga      180

actgttaaac tcctgatcta ccatacatca agattacact caggagtccc atcaaggttc      240

agtggcagtg ggtctggaac agattattct ctcaccatta gcaacctgga gcaagaagat      300

attgccactt acttttgcca acaaggtaat acgcttccgt acacgttcgg aggggggact      360

aagttggaaa taacaggagg cggcgggtct ggaggtggag gatctggtgg tggcgggtct      420

ggaggcggcg ggtctgaggt gaaactgcag gagtcaggac ctggcctggt ggcgccctca      480

cagagcctgt ccgtcacatg cactgtctca ggggtctcat tacccgacta tggtgtaagc      540

tggattcgcc agcctccacg aaagggtctg gagtggctgg gagtaatatg gggtagtgaa      600

accacatact acaactcagc tctcaaatcc agactgacca tcatcaagga caactccaag      660

agccaagttt tcttaaaaat gaacagtctg caaactgatg acacagccat ttactactgt      720

gccaaacatt attactacgg tggtagctat gctatggact actggggtca aggaacctca      780

gtcaccgtct cctcagacta caaagacgat gacgacaaga ttgaagttat gtatcctcct      840

ccttacctag acaatgagaa gagcaatgga accattatcc atgtgaaagg gaaacacctt      900

tgtccaagtc ccctatttcc cggaccttct aagccctttt gggtgctggt ggtggttggt      960

ggagtcctgg cttgctatag cttgctagta acagtggcct ttattatttt ctgggtccgc     1020

agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg     1080

cccacccgca agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc     1140

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     1200

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1260

gaactgagag tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac     1320

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1380

cgtggccggg accctgagat ggggggaaag ccgcagagaa ggaagaaccc tcaggaaggc     1440

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1500

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     1560

aaggacacct acgacgccct tcacatgcaa gccctgcccc ctcgccgcgc gaaacgcagc     1620

ggcagcggcg cgaccaactt tagcctgctg aaacaggcgg gcgatgtgga agaaaacccg     1680

ggcccgatgc cacctcctcg cctcctcttc ttcctcctct tcctcacccc catggaagtc     1740

aggcccgagg agcccctggt ggtgaaggtg gaggagggcg acaccgccgt gctgccctgc     1800

ctgaagggca ccagcgacgg ccccacccag cagctgacct ggagcaggga gagccccctg     1860

aagcccttcc tgaagtacag cctgggcgtg cccggcctgg gcgtgcacgt gaggcccgac     1920

gccatcagcg tggtgatcag gaacgtgagc cagcagatgg gcggcttcta cctgtgccag     1980

cccggccccc ccagcgagaa ggcctggcag cccggctgga ccgtgaacgt ggagggcagc     2040

ggcgagctgt tcaggtggaa cgtgagcgac ctgggcggcc tgggctgcgg cctgaagaac     2100

aggagcagcg agggccccag cagccccagc ggcaagctga tgagccccaa gctgtacgtg     2160

tgggccaagg acaggcccga gatctgggag ggcgagcccc cctgcctgcc ccccagggac     2220

agcctgaacc agagcctgag ccaggacctg accatggccc ccggcagcac cctgtggctg     2280

agctgcggcg tgccccccga cagcgtgagc aggggccccc tgagctggac ccacgtgcac     2340

cccaagggcc ccaagagcct gctgagcctg gagctgaagg acgacaggcc cgccagggag     2400

atgatcgtgg acgagaccgg cctgctgctg cccagggcca ccgcccagga cgccggcaag     2460

tggtactgca gcaggggcaa cgtgaccacc agctaccacc tggagatcac cgccaggccc     2520

gtgaaggccc acagcgacct gaggaccggc ggctggaagg gaggaggtgg gtctggaggt     2580

ggaggatctg gtggaggtgg gtctggagga ggtggatccc aggtgcagct gcaagcgtct     2640

gggggaggct tggtgcaggc tggggggtct ctgagactct cctgtgcagc ctcaggaagc     2700

atcttcgcta ttaatgaaat caatcttatg gggtggtacc gccaggctcc agggaagcag     2760

cgcgagttgg tcgcagcttg tgctagtgat ggcaacacat actatgcgga ctccgtgaag     2820

ggccgattca ccatctccag agacaacgcc gagaaaacgg tgtatctgca gatgaacaac     2880

ctgaaacctg acgacacagc cgtctattac tgtgatgcga attcgagggg gaattattat     2940

tcgggccagg ggacccaggt caccgtttcc tcaactagtg gcccgggagg ccaaggcgca     3000

gaacaaaaac tcatctcaga agaggatctg ggcgcacacc atcaccacca tcat           3054


<210> 313
<211> 1018
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 313
Met Arg Leu Leu Val Leu Leu Trp Gly Cys Leu Leu Leu Pro Gly Tyr 
1               5                   10                  15      


Glu Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
            20                  25                  30          


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
        35                  40                  45              


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
    50                  55                  60                  


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
                85                  90                  95      


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
            100                 105                 110         


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser 
145                 150                 155                 160 


Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp 
            180                 185                 190         


Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu 
        195                 200                 205             


Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe 
    210                 215                 220                 


Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser Asp Tyr Lys Asp Asp Asp Asp 
            260                 265                 270         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        275                 280                 285             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    290                 295                 300                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
305                 310                 315                 320 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                325                 330                 335     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg 
    370                 375                 380                 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
385                 390                 395                 400 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
                405                 410                 415     


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            420                 425                 430         


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        435                 440                 445             


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    450                 455                 460                 


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
465                 470                 475                 480 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                485                 490                 495     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            500                 505                 510         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        515                 520                 525             


Met Gln Ala Leu Pro Pro Arg Arg Ala Lys Arg Ser Gly Ser Gly Ala 
    530                 535                 540                 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
545                 550                 555                 560 


Gly Pro Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr 
                565                 570                 575     


Pro Met Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu 
            580                 585                 590         


Gly Asp Thr Ala Val Leu Pro Cys Leu Lys Gly Thr Ser Asp Gly Pro 
        595                 600                 605             


Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu 
    610                 615                 620                 


Lys Tyr Ser Leu Gly Val Pro Gly Leu Gly Val His Val Arg Pro Asp 
625                 630                 635                 640 


Ala Ile Ser Val Val Ile Arg Asn Val Ser Gln Gln Met Gly Gly Phe 
                645                 650                 655     


Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly 
            660                 665                 670         


Trp Thr Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val 
        675                 680                 685             


Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu 
    690                 695                 700                 


Gly Pro Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val 
705                 710                 715                 720 


Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu 
                725                 730                 735     


Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met 
            740                 745                 750         


Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser 
        755                 760                 765             


Val Ser Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro 
    770                 775                 780                 


Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Glu 
785                 790                 795                 800 


Met Ile Val Asp Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln 
                805                 810                 815     


Asp Ala Gly Lys Trp Tyr Cys Ser Arg Gly Asn Val Thr Thr Ser Tyr 
            820                 825                 830         


His Leu Glu Ile Thr Ala Arg Pro Val Lys Ala His Ser Asp Leu Arg 
        835                 840                 845             


Thr Gly Gly Trp Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    850                 855                 860                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Ala Ser 
865                 870                 875                 880 


Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                885                 890                 895     


Ala Ser Gly Ser Ile Phe Ala Ile Asn Glu Ile Asn Leu Met Gly Trp 
            900                 905                 910         


Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Cys Ala 
        915                 920                 925             


Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    930                 935                 940                 


Ile Ser Arg Asp Asn Ala Glu Lys Thr Val Tyr Leu Gln Met Asn Asn 
945                 950                 955                 960 


Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Asp Ala Asn Ser Arg 
                965                 970                 975     


Gly Asn Tyr Tyr Ser Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr 
            980                 985                 990         


Ser Gly Pro Gly Gly Gln Gly Ala  Glu Gln Lys Leu Ile  Ser Glu Glu 
        995                 1000                 1005             


Asp Leu  Gly Ala His His His  His His His 
    1010                 1015             


<210> 314
<211> 2976
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 314
atgaggcttc tggtgcttct ttggggttgc ttgctgttgc ccggttacga agcagacatc       60

cagatgacac agactacatc ctccctgtct gcctctctgg gagacagagt caccatcagt      120

tgcagggcaa gtcaggacat tagtaaatat ttaaattggt atcagcagaa accagatgga      180

actgttaaac tcctgatcta ccatacatca agattacact caggagtccc atcaaggttc      240

agtggcagtg ggtctggaac agattattct ctcaccatta gcaacctgga gcaagaagat      300

attgccactt acttttgcca acaaggtaat acgcttccgt acacgttcgg aggggggact      360

aagttggaaa taacaggagg cggcgggtct ggaggtggag gatctggtgg tggcgggtct      420

ggaggcggcg ggtctgaggt gaaactgcag gagtcaggac ctggcctggt ggcgccctca      480

cagagcctgt ccgtcacatg cactgtctca ggggtctcat tacccgacta tggtgtaagc      540

tggattcgcc agcctccacg aaagggtctg gagtggctgg gagtaatatg gggtagtgaa      600

accacatact acaactcagc tctcaaatcc agactgacca tcatcaagga caactccaag      660

agccaagttt tcttaaaaat gaacagtctg caaactgatg acacagccat ttactactgt      720

gccaaacatt attactacgg tggtagctat gctatggact actggggtca aggaacctca      780

gtcaccgtct cctcagacta caaagacgat gacgacaaga ttgaagttat gtatcctcct      840

ccttacctag acaatgagaa gagcaatgga accattatcc atgtgaaagg gaaacacctt      900

tgtccaagtc ccctatttcc cggaccttct aagccctttt gggtgctggt ggtggttggt      960

ggagtcctgg cttgctatag cttgctagta acagtggcct ttattatttt ctgggtccgc     1020

agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg     1080

cccacccgca agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc     1140

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     1200

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1260

gaactgagag tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac     1320

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1380

cgtggccggg accctgagat ggggggaaag ccgcagagaa ggaagaaccc tcaggaaggc     1440

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1500

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     1560

aaggacacct acgacgccct tcacatgcaa gccctgcccc ctcgccgcgc gaaacgcagc     1620

ggcagcggcg cgaccaactt tagcctgctg aaacaggcgg gcgatgtgga agaaaacccg     1680

ggcccgatgg agtttgggct gagctgggtt ttcctcgttg ctctttttag aggtgtccag     1740

tgtcaggtgc agctgcagga gtctggggga ggcttggtgc aggctggggg gtcccttaga     1800

ctctcctgtg tagcctctgg aagcatcaga agtatcaatg tcatgggctg gtaccgccag     1860

gctccaggga agcagcgcga gttggtcgca gcttgtgcta gtgatggcaa cacatactat     1920

gcggactccg tgaagggccg attcaccatc tccagagaca acgccgagaa aacggtgtat     1980

ctgcagatga acaacctgaa acctgacgac acagccgtct attactgtga tgcgaattcg     2040

agggggaatt attattcggg ccaggggacc caggtcaccg tttcctcaac tagtggcccg     2100

ggaggccaag gcgcaggagg aggtgggtct ggaggtggag gatctggtgg aggtgggtct     2160

ggaggaggtg gatcccccga ggaacctcta gtggtgaagg tggaagaggg agataccgct     2220

gccctgtggt gcctcaaggg gacctcagat ggccccactc agcagctgac ctggtctcgg     2280

gagtccccgc ttaaaccctt cttaaaatac agcctggggg tgccaggcct gggagtgcac     2340

gtgaggcccg acgccatcag cgtggttatc cggaacgtct ctcaacagat ggggggcttc     2400

tacctgtgcc agccggggcc cccctctgag aaggcctggc agcctggctg gacagtcaat     2460

gtggagggca gcggggagct gttccggtgg aatgtttcgg acctaggtgg cctgggctgt     2520

ggcctgaaga acaggtcctc agagggcccc agctcccctt ccgggaagct catgagcccc     2580

aagctgtatg tgtgggccaa agaccgccct gagatctggg agggagagcc tccgtgtctc     2640

ccaccgaggg acagcctgaa ccagagcctc agccgggacc tcaccgttgc ccctggctcc     2700

acactctggc tgtcctgtgg ggtaccccct gactctgtgt ccaggggccc cctctcctgg     2760

acccatgtgc accccaaggg gcctaagtca ttgctgagcc tagagctgaa ggacgatcgc     2820

ccggccagag atatgtgggt aatgggcacg agcctgatgt tgccccgggc cacagctcaa     2880

gacgctggaa agtggtattg tcaccgtggc aacctgacca tgtcattcca cctggagatc     2940

actgctcggc catctagaca tcatcaccat caccat                               2976


<210> 315
<211> 992
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 315
Met Arg Leu Leu Val Leu Leu Trp Gly Cys Leu Leu Leu Pro Gly Tyr 
1               5                   10                  15      


Glu Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
            20                  25                  30          


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
        35                  40                  45              


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
    50                  55                  60                  


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
                85                  90                  95      


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
            100                 105                 110         


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser 
145                 150                 155                 160 


Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp 
            180                 185                 190         


Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu 
        195                 200                 205             


Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe 
    210                 215                 220                 


Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser Asp Tyr Lys Asp Asp Asp Asp 
            260                 265                 270         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        275                 280                 285             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    290                 295                 300                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
305                 310                 315                 320 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                325                 330                 335     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg 
    370                 375                 380                 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
385                 390                 395                 400 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
                405                 410                 415     


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            420                 425                 430         


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        435                 440                 445             


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    450                 455                 460                 


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
465                 470                 475                 480 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                485                 490                 495     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            500                 505                 510         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        515                 520                 525             


Met Gln Ala Leu Pro Pro Arg Arg Ala Lys Arg Ser Gly Ser Gly Ala 
    530                 535                 540                 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
545                 550                 555                 560 


Gly Pro Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe 
                565                 570                 575     


Arg Gly Val Gln Cys Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu 
            580                 585                 590         


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser 
        595                 600                 605             


Ile Arg Ser Ile Asn Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
    610                 615                 620                 


Gln Arg Glu Leu Val Ala Ala Cys Ala Ser Asp Gly Asn Thr Tyr Tyr 
625                 630                 635                 640 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu 
                645                 650                 655     


Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala 
            660                 665                 670         


Val Tyr Tyr Cys Asp Ala Asn Ser Arg Gly Asn Tyr Tyr Ser Gly Gln 
        675                 680                 685             


Gly Thr Gln Val Thr Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly 
    690                 695                 700                 


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
705                 710                 715                 720 


Gly Gly Gly Gly Ser Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu 
                725                 730                 735     


Gly Asp Thr Ala Ala Leu Trp Cys Leu Lys Gly Thr Ser Asp Gly Pro 
            740                 745                 750         


Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu 
        755                 760                 765             


Lys Tyr Ser Leu Gly Val Pro Gly Leu Gly Val His Val Arg Pro Asp 
    770                 775                 780                 


Ala Ile Ser Val Val Ile Arg Asn Val Ser Gln Gln Met Gly Gly Phe 
785                 790                 795                 800 


Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly 
                805                 810                 815     


Trp Thr Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val 
            820                 825                 830         


Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu 
        835                 840                 845             


Gly Pro Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val 
    850                 855                 860                 


Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu 
865                 870                 875                 880 


Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu Ser Arg Asp Leu Thr Val 
                885                 890                 895     


Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser 
            900                 905                 910         


Val Ser Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro 
        915                 920                 925             


Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp 
    930                 935                 940                 


Met Trp Val Met Gly Thr Ser Leu Met Leu Pro Arg Ala Thr Ala Gln 
945                 950                 955                 960 


Asp Ala Gly Lys Trp Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe 
                965                 970                 975     


His Leu Glu Ile Thr Ala Arg Pro Ser Arg His His His His His His 
            980                 985                 990         


<210> 316
<211> 3345
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 316
atgaggcttc tggtgcttct ttggggttgc ttgctgttgc ccggttacga agcagacatc       60

cagatgacac agactacatc ctccctgtct gcctctctgg gagacagagt caccatcagt      120

tgcagggcaa gtcaggacat tagtaaatat ttaaattggt atcagcagaa accagatgga      180

actgttaaac tcctgatcta ccatacatca agattacact caggagtccc atcaaggttc      240

agtggcagtg ggtctggaac agattattct ctcaccatta gcaacctgga gcaagaagat      300

attgccactt acttttgcca acaaggtaat acgcttccgt acacgttcgg aggggggact      360

aagttggaaa taacaggagg cggcgggtct ggaggtggag gatctggtgg tggcgggtct      420

ggaggcggcg ggtctgaggt gaaactgcag gagtcaggac ctggcctggt ggcgccctca      480

cagagcctgt ccgtcacatg cactgtctca ggggtctcat tacccgacta tggtgtaagc      540

tggattcgcc agcctccacg aaagggtctg gagtggctgg gagtaatatg gggtagtgaa      600

accacatact acaactcagc tctcaaatcc agactgacca tcatcaagga caactccaag      660

agccaagttt tcttaaaaat gaacagtctg caaactgatg acacagccat ttactactgt      720

gccaaacatt attactacgg tggtagctat gctatggact actggggtca aggaacctca      780

gtcaccgtct cctcagacta caaagacgat gacgacaaga ttgaagttat gtatcctcct      840

ccttacctag acaatgagaa gagcaatgga accattatcc atgtgaaagg gaaacacctt      900

tgtccaagtc ccctatttcc cggaccttct aagccctttt gggtgctggt ggtggttggt      960

ggagtcctgg cttgctatag cttgctagta acagtggcct ttattatttt ctgggtccgc     1020

agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg     1080

cccacccgca agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc     1140

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     1200

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1260

gaactgagag tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac     1320

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1380

cgtggccggg accctgagat ggggggaaag ccgcagagaa ggaagaaccc tcaggaaggc     1440

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1500

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     1560

aaggacacct acgacgccct tcacatgcaa gccctgcccc ctcgccgcgc gaaacgcagc     1620

ggcagcggcg cgaccaactt tagcctgctg aaacaggcgg gcgatgtgga agaaaacccg     1680

ggcccgatgc cacctcctcg cctcctcttc ttcctcctct tcctcacccc catggaagtc     1740

aggcccgagg aacctctagt ggtgaaggtg gaagagggag ataacgctgt gctgcagtgc     1800

ctcaagggga cctcagatgg ccccactcag cagctgacct ggtctcggga gtccccgctt     1860

aaacccttct taaaactcag cctggggctg ccaggcctgg gaatccacat gaggcccctg     1920

gccatctggc ttttcatctt caacgtctct caacagatgg ggggcttcta cctgtgccag     1980

ccggggcccc cctctgagaa ggcctggcag cctggctgga cagtcaatgt ggagggcagc     2040

ggggagctgt tccggtggaa tgtttcggac ctaggtggcc tgggctgtgg cctgaagaac     2100

aggtcctcag agggccccag ctccccttcc gggaagctca tgagccccaa gctgtatgtg     2160

tgggccaaag accgccctga gatctgggag ggagagcctc cgtgtctccc accgagggac     2220

agcctgaacc agagcctcag ccaggacctc accatggccc ctggctccac actctggctg     2280

tcctgtgggg taccccctga ctctgtgtcc cgcggccccc tctcctggac ccatgtgcac     2340

cccaaggggc ctaagtcatt gctgagccta gagctgaagg acgatcgccc ggccagagat     2400

atgtgggtaa tggagacggg tctgttgttg ccccgggcca cagctcaaga cgctggaaag     2460

tattattgtc accgtggcaa cctgaccatg tcattccacc tggagatcac tgctcggcct     2520

ggcggcggcg ggtctggagg tggaggatct ggtggtggcg ggtctggtgg cggcgggtct     2580

gaggtgcagc tggtggagtc tggtggtggt cttgttcaac ctggtggttc tcttcgtctt     2640

tcttgtgctg cttctggttt taatattaaa gatacttata ttcattgggt tcgtcaagct     2700

cctggtaaag gtcttgaatg ggttgctcgt atttatccta ctaatggtta tactcgttat     2760

gctgattctg ttaaaggtcg ttttactatt tctgctgata cttctaaaaa tactgcttat     2820

cttcaaatga actctcttcg tgctgaagat actgctgttt attattgttc tcgttggggt     2880

ggtgatggtt tttatgctat ggattattgg ggtcaaggta ctcttgtcac cgtctcctca     2940

gctagcaccg ggggcggcgg gtctggaggt ggaggatctg gtggcggcgg gtctgacatc     3000

cagatgaccc agtctccttc ttctctttct gcttctgttg gtgatcgtgt tactattact     3060

tgtcgtgctt ctcaagatgt taatactgct gttgcttggt atcaacaaaa acctggtaaa     3120

gctcctaaac ttcttattta ttctgcttct tttctttatt ctggtgttcc ttctcgtttt     3180

tctggttctc gttctggtac tgattttact cttactattt cttctcttca acctgaagat     3240

tttgctactt attattgtca acaacattat actactcctc ctacttttgg tcaaggtacc     3300

aaggtggaga tcaaacgtac gtctagacat catcaccatc accat                     3345


<210> 317
<211> 1115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 317
Met Arg Leu Leu Val Leu Leu Trp Gly Cys Leu Leu Leu Pro Gly Tyr 
1               5                   10                  15      


Glu Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
            20                  25                  30          


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
        35                  40                  45              


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
    50                  55                  60                  


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
                85                  90                  95      


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
            100                 105                 110         


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser 
145                 150                 155                 160 


Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp 
            180                 185                 190         


Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu 
        195                 200                 205             


Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe 
    210                 215                 220                 


Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser Asp Tyr Lys Asp Asp Asp Asp 
            260                 265                 270         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        275                 280                 285             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    290                 295                 300                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
305                 310                 315                 320 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                325                 330                 335     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg 
    370                 375                 380                 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
385                 390                 395                 400 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
                405                 410                 415     


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            420                 425                 430         


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        435                 440                 445             


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    450                 455                 460                 


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
465                 470                 475                 480 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                485                 490                 495     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            500                 505                 510         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        515                 520                 525             


Met Gln Ala Leu Pro Pro Arg Arg Ala Lys Arg Ser Gly Ser Gly Ala 
    530                 535                 540                 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
545                 550                 555                 560 


Gly Pro Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr 
                565                 570                 575     


Pro Met Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu 
            580                 585                 590         


Gly Asp Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro 
        595                 600                 605             


Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu 
    610                 615                 620                 


Lys Leu Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu 
625                 630                 635                 640 


Ala Ile Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe 
                645                 650                 655     


Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly 
            660                 665                 670         


Trp Thr Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val 
        675                 680                 685             


Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu 
    690                 695                 700                 


Gly Pro Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val 
705                 710                 715                 720 


Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu 
                725                 730                 735     


Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met 
            740                 745                 750         


Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser 
        755                 760                 765             


Val Ser Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro 
    770                 775                 780                 


Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp 
785                 790                 795                 800 


Met Trp Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln 
                805                 810                 815     


Asp Ala Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe 
            820                 825                 830         


His Leu Glu Ile Thr Ala Arg Pro Gly Gly Gly Gly Ser Gly Gly Gly 
        835                 840                 845             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
    850                 855                 860                 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
865                 870                 875                 880 


Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp 
                885                 890                 895     


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr 
            900                 905                 910         


Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe 
        915                 920                 925             


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
    930                 935                 940                 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly 
945                 950                 955                 960 


Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
                965                 970                 975     


Thr Val Ser Ser Ala Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            980                 985                 990         


Ser Gly Gly Gly Gly Ser Asp Ile  Gln Met Thr Gln Ser  Pro Ser Ser 
        995                 1000                 1005             


Leu Ser  Ala Ser Val Gly Asp  Arg Val Thr Ile Thr  Cys Arg Ala 
    1010                 1015                 1020             


Ser Gln  Asp Val Asn Thr Ala  Val Ala Trp Tyr Gln  Gln Lys Pro 
    1025                 1030                 1035             


Gly Lys  Ala Pro Lys Leu Leu  Ile Tyr Ser Ala Ser  Phe Leu Tyr 
    1040                 1045                 1050             


Ser Gly  Val Pro Ser Arg Phe  Ser Gly Ser Arg Ser  Gly Thr Asp 
    1055                 1060                 1065             


Phe Thr  Leu Thr Ile Ser Ser  Leu Gln Pro Glu Asp  Phe Ala Thr 
    1070                 1075                 1080             


Tyr Tyr  Cys Gln Gln His Tyr  Thr Thr Pro Pro Thr  Phe Gly Gln 
    1085                 1090                 1095             


Gly Thr  Lys Val Glu Ile Lys  Arg Thr Ser Arg His  His His His 
    1100                 1105                 1110             


His His  
    1115 


<210> 318
<211> 1614
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 318
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg cagcaccggc       60

gacatggccc aggtgcagct gcaggagagc ggccccggcc tggtgaagcc cagcgagacc      120

ctgagcctga cctgcgtggt gagcggcggc agcatcagca gcagcaactg gtggagctgg      180

gtgaggcagc cccccggcaa gggcctggag tggatcggcg agatctacca cagcggcagc      240

cccgactaca accccagcct gaagagcagg gtgaccatca gcgtggacaa gagcaggaac      300

cagttcagcc tgaagctgag cagcgtgacc gccgccgaca ccgccgtgta ctactgcgcc      360

aaggtgagca ccggcggctt cttcgactac tggggccagg gcaccctggt gaccgtgagc      420

agcggcggcg gcggcagcgg cggcggcggc agcggcggcg gcggcagcga gatcgagctg      480

acccagagcc ccagcagcct gagcgccagc gtgggcgaca gggtgaccat cacctgcagg      540

gccagccaga gcatcagcag ctacctgaac tggtaccagc agaagcccgg caaggccccc      600

aagctgctga tctacgccgc cagcagcctg cagagcggcg tgcccagcag gttcagcggc      660

agcggcagcg gcaccgactt caccctgacc atcagcagcc tgcagcccga ggacttcgcc      720

acctactact gccagcagag ctacagcacc ccccccacct tcggccccgg caccaaggtg      780

gagatcaaga ggacctcttc tgactacaaa gacgatgacg acaagattga agttatgtat      840

cctcctcctt acctagacaa tgagaagagc aatggaacca ttatccatgt gaaagggaaa      900

cacctttgtc caagtcccct atttcccgga ccttctaagc ccttttgggt gctggtggtg      960

gttggtggag tcctggcttg ctatagcttg ctagtaacag tggcctttat tattttctgg     1020

gtgaggagta agaggagcag gctcctgcac agtgactaca tgaacatgac tccccgccgc     1080

cccgggccca cccgcaagca ttaccagccc tatgccccac cacgcgactt cgcagcctat     1140

cgctccaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     1200

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     1260

ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta ccagcagggc     1320

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     1380

aagagacgtg gccgggaccc tgagatgggg ggaaagccgc agagaaggaa gaaccctcag     1440

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1500

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1560

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1614


<210> 319
<211> 537
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 319
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Met Ala Gln Val Gln Leu Gln Glu Ser Gly Pro 
            20                  25                  30          


Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser 
        35                  40                  45              


Gly Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser 
65                  70                  75                  80  


Pro Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
                85                  90                  95      


Lys Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
        195                 200                 205             


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro 
                245                 250                 255     


Gly Thr Lys Val Glu Ile Lys Arg Thr Ser Ser Asp Tyr Lys Asp Asp 
            260                 265                 270         


Asp Asp Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
        275                 280                 285             


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
    290                 295                 300                 


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
            340                 345                 350         


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
        355                 360                 365             


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg 
    370                 375                 380                 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
385                 390                 395                 400 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                405                 410                 415     


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
            420                 425                 430         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        435                 440                 445             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    450                 455                 460                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
465                 470                 475                 480 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                485                 490                 495     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            500                 505                 510         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        515                 520                 525             


Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535         


<210> 320
<211> 2100
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 320
atggagtttg ggctgagctg ggttttcctc gttgctcttt ttagaggtgt ccagtgtcag       60

gtgcagctgg tgcagagcgg cgccgaggtg aagaagcccg gcgagagcgt gaaggtgagc      120

tgcaaggcca gcggctacac cttcaccaac tacggcatga actgggtgaa gcaggccccc      180

ggccagggcc tggagtggat gggctggatc aacacctaca ccggcgagcc cacctacgcc      240

gacaagttcc agggcagggt gaccatgacc accgacacca gcaccagcac cgcctacatg      300

gagatcagga acctgggcgg cgacgacacc gccgtgtact actgcgccag gtggagctgg      360

agcgacggct actacgtgta cttcgactac tggggccagg gcaccagcgt gaccgtgagc      420

agcggcggcg gcggcagcgg cggcggcggc agcggcggcg gcggcagcga catcgtgatg      480

acccagagcc ccgacagcct gaccgtgagc ctgggcgaga ggaccaccat caactgcaag      540

agcagccaga gcgtgctgga cagcagcacc aacaagaaca gcctggcctg gtaccagcag      600

aagcccggcc agccccccaa gctgctgctg agctgggcca gcaccaggga gagcggcatc      660

cccgacaggt tcagcggcag cggcagcggc accgacttca ccctgaccat cgacagcccc      720

cagcccgagg acagcgccac ctactactgc cagcagagcg cccacttccc catcaccttc      780

ggccagggca ccaggctgga gatcaaggga ggaggtgggt ctggaggtgg aggatctggt      840

ggaggtgggt ctggaggagg tggatcccag gtgcagctgc aggagtctgg gggaggcttg      900

gtgcaggctg gggggtccct tagactctcc tgtgtagcct ctggaagcat cagaagtatc      960

aatgtcatgg gctggtaccg ccaggctcca gggaagcagc gcgagttggt cgcagcttgt     1020

gctagtgatg gcaacacata ctatgcggac tccgtgaagg gccgattcac catctccaga     1080

gacaacgccg agaaaacggt gtatctgcag atgaacaacc tgaaacctga cgacacagcc     1140

gtctattact gtgatgcgaa ttcgaggggg aattattatt cgggccaggg gacccaggtc     1200

accgtttcct caactagtgg cccgggaggc caaggtgcag gaggaggggg gtctgggggt     1260

ggaggatctg gtggaggtgg gtctggagga ggtggatccc ccgaggaacc tctagtggtg     1320

aaggtggaag agggagatac cgctgccctg tggtgcctca aggggacctc agatggcccc     1380

actcagcagc tgacctggtc tcgggagtcc ccgcttaaac ccttcttaaa atacagcctg     1440

ggggtgccag gcctgggagt gcacgtgagg cccgacgcca tcagcgtggt tatccggaac     1500

gtctctcaac agatgggggg cttctacctg tgccagccgg ggcccccctc tgagaaggcc     1560

tggcagcctg gctggacagt caatgtggag ggcagcgggg agctgttccg gtggaatgtt     1620

tcggacctag gtggcctggg ctgtggcctg aagaacaggt cctcagaggg ccccagctcc     1680

ccttccggga agctcatgag ccccaagctg tatgtgtggg ccaaagaccg ccctgagatc     1740

tgggagggag agcctccgtg tctcccaccg agggacagcc tgaaccagag cctcagccgg     1800

gacctcaccg ttgcccctgg ctccacactc tggctgtcct gtggggtacc ccctgactct     1860

gtgtccaggg gccccctctc ctggacccat gtgcacccca aggggcctaa gtcattgctg     1920

agcctagagc tgaaggacga tcgcccggcc agagatatgt gggtaatggg cacgagcctg     1980

atgttgcccc gggccacagc tcaagacgct ggaaagtggt attgtcaccg tggcaacctg     2040

accatgtcat tccacctgga gatcactgct cggccatcta gacatcatca ccatcaccat     2100


<210> 321
<211> 700
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 321
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala 
65                  70                  75                  80  


Asp Lys Phe Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
145                 150                 155                 160 


Thr Gln Ser Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr 
                165                 170                 175     


Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys 
            180                 185                 190         


Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Leu Ser Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro 
225                 230                 235                 240 


Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe 
                245                 250                 255     


Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
    290                 295                 300                 


Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Ile Arg Ser Ile 
305                 310                 315                 320 


Asn Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
                325                 330                 335     


Val Ala Ala Cys Ala Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
            340                 345                 350         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Lys Thr Val Tyr 
        355                 360                 365             


Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
    370                 375                 380                 


Asp Ala Asn Ser Arg Gly Asn Tyr Tyr Ser Gly Gln Gly Thr Gln Val 
385                 390                 395                 400 


Thr Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly Ala Gly Gly Gly 
                405                 410                 415     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            420                 425                 430         


Ser Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Thr Ala 
        435                 440                 445             


Ala Leu Trp Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu 
    450                 455                 460                 


Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Tyr Ser Leu 
465                 470                 475                 480 


Gly Val Pro Gly Leu Gly Val His Val Arg Pro Asp Ala Ile Ser Val 
                485                 490                 495     


Val Ile Arg Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln 
            500                 505                 510         


Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn 
        515                 520                 525             


Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly 
    530                 535                 540                 


Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser 
545                 550                 555                 560 


Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp 
                565                 570                 575     


Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp 
            580                 585                 590         


Ser Leu Asn Gln Ser Leu Ser Arg Asp Leu Thr Val Ala Pro Gly Ser 
        595                 600                 605             


Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly 
    610                 615                 620                 


Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu 
625                 630                 635                 640 


Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met 
                645                 650                 655     


Gly Thr Ser Leu Met Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys 
            660                 665                 670         


Trp Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile 
        675                 680                 685             


Thr Ala Arg Pro Ser Arg His His His His His His 
    690                 695                 700 


<210> 322
<211> 2035
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 322
atggagtttg ggctgagctg ggttttcctc gttgctcttt ttagaggtgt ccagtgtgac       60

atggcccagg tgcagctgca ggagagcggc cccggcctgg tgaagcccag cgagaccctg      120

agcctgacct gcgtggtgag cggcggcagc atcagcagca gcaactggtg gagctgggtg      180

aggcagcccc ccggcaaggg cctggagtgg atcggcgaga tctaccacag cggcagcccc      240

gactacaacc ccagcctgaa gagcagggtg accatcagcg tggacaagag caggaaccag      300

ttcagcctga agctgagcag cgtgaccgcc gccgacaccg ccgtgtacta ctgcgccaag      360

gtgagcaccg gcggcttctt cgactactgg ggccagggca ccctggtgac cgtgagcagc      420

ggcggcggcg gcagcggcgg cggcggcagc ggcggcggcg gcagcgagat cgagctgacc      480

cagagcccca gcagcctgag cgccagcgtg ggcgacaggg tgaccatcac ctgcagggcc      540

agccagagca tcagcagcta cctgaactgg taccagcaga agcccggcaa ggcccccaag      600

ctgctgatct acgccgccag cagcctgcag agcggcgtgc ccagcaggtt cagcggcagc      660

ggcagcggca ccgacttcac cctgaccatc agcagcctgc agcccgagga cttcgccacc      720

tactactgcc agcagagcta cagcaccccc cccaccttcg gccccggcac caaggtggag      780

atcaagagga ccggcggcgg aggatctggc ggaggtggaa gcggaggcgg aggaagcggt      840

ggcggcggat ctcaggtgca gctgcaggag tctgggggag gcttggtgca ggctgggggg      900

tcccttagac tctcctgtgt agcctctgga agcatcagaa gtatcaatgt catgggctgg      960

taccgccagg ctccagggaa gcagcgcgag ttggtcgcag cttgtgctag tgatggcaac     1020

acatactatg cggactccgt gaagggccga ttcaccatct ccagagacaa cgccgagaaa     1080

acggtgtatc tgcagatgaa caacctgaaa cctgacgaca cagccgtcta ttactgtgat     1140

gcgaattcga gggggaatta ttattcgggc caggggaccc aggtcaccgt ttcctcagga     1200

ggaggggggt ctgggggtgg aggatctggt ggaggtgggt ctggaggagg tggatccccc     1260

gaggaacctc tagtggtgaa ggtggaagag ggagataccg ctgccctgtg gtgcctcaag     1320

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc     1380

ttcttaaaat acagcctggg ggtgccaggc ctgggagtgc acgtgaggcc cgacgccatc     1440

agcgtggtta tccggaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg     1500

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag     1560

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc     1620

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc     1680

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg     1740

aaccagagcc tcagccggga cctcaccgtt gcccctggct ccacactctg gctgtcctgt     1800

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag     1860

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg     1920

gtaatgggca cgagcctgat gttgccccgg gccacagctc aagacgctgg aaagtggtat     1980

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccat          2035


<210> 323
<211> 678
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 323
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Asp Met Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Arg Thr Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
        275                 280                 285             


Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu 
    290                 295                 300                 


Ser Cys Val Ala Ser Gly Ser Ile Arg Ser Ile Asn Val Met Gly Trp 
305                 310                 315                 320 


Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Cys Ala 
                325                 330                 335     


Ser Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            340                 345                 350         


Ile Ser Arg Asp Asn Ala Glu Lys Thr Val Tyr Leu Gln Met Asn Asn 
        355                 360                 365             


Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Asp Ala Asn Ser Arg 
    370                 375                 380                 


Gly Asn Tyr Tyr Ser Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            420                 425                 430         


Thr Ala Ala Leu Trp Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        435                 440                 445             


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Tyr 
    450                 455                 460                 


Ser Leu Gly Val Pro Gly Leu Gly Val His Val Arg Pro Asp Ala Ile 
465                 470                 475                 480 


Ser Val Val Ile Arg Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                485                 490                 495     


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            500                 505                 510         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        515                 520                 525             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    530                 535                 540                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
545                 550                 555                 560 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                565                 570                 575     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Arg Asp Leu Thr Val Ala Pro 
            580                 585                 590         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        595                 600                 605             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    610                 615                 620                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
625                 630                 635                 640 


Val Met Gly Thr Ser Leu Met Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                645                 650                 655     


Gly Lys Trp Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            660                 665                 670         


Glu Ile Thr Ala Arg Pro 
        675             


<210> 324
<211> 1668
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 324
atggagtttg ggctgagctg ggttttcctc gttgctcttt ttagaggtgt ccagtgtcag       60

gtgcagctgg tgcagagcgg cgccgaggtg aagaagcccg gcgagagcgt gaaggtgagc      120

tgcaaggcca gcggctacac cttcaccaac tacggcatga actgggtgaa gcaggccccc      180

ggccagggcc tggagtggat gggctggatc aacacctaca ccggcgagcc cacctacgcc      240

gacaagttcc agggcagggt gaccatgacc accgacacca gcaccagcac cgcctacatg      300

gagatcagga acctgggcgg cgacgacacc gccgtgtact actgcgccag gtggagctgg      360

agcgacggct actacgtgta cttcgactac tggggccagg gcaccagcgt gaccgtgagc      420

agcggcggcg gcggcagcgg cggcggcggc agcggcggcg gcggcagcga catcgtgatg      480

acccagagcc ccgacagcct gaccgtgagc ctgggcgaga ggaccaccat caactgcaag      540

agcagccaga gcgtgctgga cagcagcacc aacaagaaca gcctggcctg gtaccagcag      600

aagcccggcc agccccccaa gctgctgctg agctgggcca gcaccaggga gagcggcatc      660

cccgacaggt tcagcggcag cggcagcggc accgacttca ccctgaccat cgacagcccc      720

cagcccgagg acagcgccac ctactactgc cagcagagcg cccacttccc catcaccttc      780

ggccagggca ccaggctgga gatcaaggga ggaggtgggt ctggaggtgg aggatctggt      840

ggaggtgggt ctggaggagg tggatccccc gaggaacctc tagtggtgaa ggtggaagag      900

ggagataccg ctgccctgtg gtgcctcaag gggacctcag atggccccac tcagcagctg      960

acctggtctc gggagtcccc gcttaaaccc ttcttaaaat acagcctggg ggtgccaggc     1020

ctgggagtgc acgtgaggcc cgacgccatc agcgtggtta tccggaacgt ctctcaacag     1080

atggggggct tctacctgtg ccagccgggg cccccctctg agaaggcctg gcagcctggc     1140

tggacagtca atgtggaggg cagcggggag ctgttccggt ggaatgtttc ggacctaggt     1200

ggcctgggct gtggcctgaa gaacaggtcc tcagagggcc ccagctcccc ttccgggaag     1260

ctcatgagcc ccaagctgta tgtgtgggcc aaagaccgcc ctgagatctg ggagggagag     1320

cctccgtgtc tcccaccgag ggacagcctg aaccagagcc tcagccggga cctcaccgtt     1380

gcccctggct ccacactctg gctgtcctgt ggggtacccc ctgactctgt gtccaggggc     1440

cccctctcct ggacccatgt gcaccccaag gggcctaagt cattgctgag cctagagctg     1500

aaggacgatc gcccggccag agatatgtgg gtaatgggca cgagcctgat gttgccccgg     1560

gccacagctc aagacgctgg aaagtggtat tgtcaccgtg gcaacctgac catgtcattc     1620

cacctggaga tcactgctcg gccatctaga catcatcacc atcaccat                  1668


<210> 325
<211> 556
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 325
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala 
65                  70                  75                  80  


Asp Lys Phe Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
145                 150                 155                 160 


Thr Gln Ser Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr 
                165                 170                 175     


Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys 
            180                 185                 190         


Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Leu Ser Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro 
225                 230                 235                 240 


Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe 
                245                 250                 255     


Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Thr Ala 
    290                 295                 300                 


Ala Leu Trp Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu 
305                 310                 315                 320 


Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Tyr Ser Leu 
                325                 330                 335     


Gly Val Pro Gly Leu Gly Val His Val Arg Pro Asp Ala Ile Ser Val 
            340                 345                 350         


Val Ile Arg Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln 
        355                 360                 365             


Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn 
    370                 375                 380                 


Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly 
385                 390                 395                 400 


Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser 
                405                 410                 415     


Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp 
            420                 425                 430         


Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp 
        435                 440                 445             


Ser Leu Asn Gln Ser Leu Ser Arg Asp Leu Thr Val Ala Pro Gly Ser 
    450                 455                 460                 


Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly 
465                 470                 475                 480 


Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu 
                485                 490                 495     


Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met 
            500                 505                 510         


Gly Thr Ser Leu Met Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys 
        515                 520                 525             


Trp Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile 
    530                 535                 540                 


Thr Ala Arg Pro Ser Arg His His His His His His 
545                 550                 555     


<210> 326
<211> 3696
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 326
atgaggcttc tggtgcttct ttggggttgc ttgctgttgc ccggttacga agcagacatc       60

cagatgacac agactacatc ctccctgtct gcctctctgg gagacagagt caccatcagt      120

tgcagggcaa gtcaggacat tagtaaatat ttaaattggt atcagcagaa accagatgga      180

actgttaaac tcctgatcta ccatacatca agattacact caggagtccc atcaaggttc      240

agtggcagtg ggtctggaac agattattct ctcaccatta gcaacctgga gcaagaagat      300

attgccactt acttttgcca acaaggtaat acgcttccgt acacgttcgg aggggggact      360

aagttggaaa taacaggagg cggcgggtct ggaggtggag gatctggtgg tggcgggtct      420

ggaggcggcg ggtctgaggt gaaactgcag gagtcaggac ctggcctggt ggcgccctca      480

cagagcctgt ccgtcacatg cactgtctca ggggtctcat tacccgacta tggtgtaagc      540

tggattcgcc agcctccacg aaagggtctg gagtggctgg gagtaatatg gggtagtgaa      600

accacatact acaactcagc tctcaaatcc agactgacca tcatcaagga caactccaag      660

agccaagttt tcttaaaaat gaacagtctg caaactgatg acacagccat ttactactgt      720

gccaaacatt attactacgg tggtagctat gctatggact actggggtca aggaacctca      780

gtcaccgtct cctcaattga agttatgtat cctcctcctt acctagacaa tgagaagagc      840

aatggaacca ttatccatgt gaaagggaaa cacctttgtc caagtcccct atttcccgga      900

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      960

ctagtaacag tggcctttat tattttctgg gtccgcagta agaggagcag gctcctgcac     1020

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc     1080

tatgccccac cacgcgactt cgcagcctat cgctccaaac ggggcagaaa gaaactcctg     1140

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1200

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1260

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1320

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1380

ggaaagccgc agagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1440

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1500

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1560

atgcaagccc tgccccctcg ccgcgcgaaa cgcagcggca gcggcgcgac caactttagc     1620

ctgctgaaac aggcgggcga tgtggaagaa aacccgggcc cgatggagtt tgggctgagc     1680

tgggttttcc tcgttgctct ttttagaggt gtccagtgtg acatggccca ggtgcagctg     1740

caggagagcg gccccggcct ggtgaagccc agcgagaccc tgagcctgac ctgcgtggtg     1800

agcggcggca gcatcagcag cagcaactgg tggagctggg tgaggcagcc ccccggcaag     1860

ggcctggagt ggatcggcga gatctaccac agcggcagcc ccgactacaa ccccagcctg     1920

aagagcaggg tgaccatcag cgtggacaag agcaggaacc agttcagcct gaagctgagc     1980

agcgtgaccg ccgccgacac cgccgtgtac tactgcgcca aggtgagcac cggcggcttc     2040

ttcgactact ggggccaggg caccctggtg accgtgagca gcggcggcgg cggcagcggc     2100

ggcggcggca gcggcggcgg cggcagcgag atcgagctga cccagagccc cagcagcctg     2160

agcgccagcg tgggcgacag ggtgaccatc acctgcaggg ccagccagag catcagcagc     2220

tacctgaact ggtaccagca gaagcccggc aaggccccca agctgctgat ctacgccgcc     2280

agcagcctgc agagcggcgt gcccagcagg ttcagcggca gcggcagcgg caccgacttc     2340

accctgacca tcagcagcct gcagcccgag gacttcgcca cctactactg ccagcagagc     2400

tacagcaccc cccccacctt cggccccggc accaaggtgg agatcaagag gaccggcggc     2460

ggaggatctg gcggaggtgg aagcggaggc ggaggaagcg gtggcggcgg atctcaggtg     2520

cagctgcagg agtctggggg aggcttggtg caggctgggg ggtcccttag actctcctgt     2580

gtagcctctg gaagcatcag aagtatcaat gtcatgggct ggtaccgcca ggctccaggg     2640

aagcagcgcg agttggtcgc agcttgtgct agtgatggca acacatacta tgcggactcc     2700

gtgaagggcc gattcaccat ctccagagac aacgccgaga aaacggtgta tctgcagatg     2760

aacaacctga aacctgacga cacagccgtc tattactgtg atgcgaattc gagggggaat     2820

tattattcgg gccaggggac ccaggtcacc gtttcctcag gaggaggggg gtctgggggt     2880

ggaggatctg gtggaggtgg gtctggagga ggtggatccc ccgaggaacc tctagtggtg     2940

aaggtggaag agggagatac cgctgccctg tggtgcctca aggggacctc agatggcccc     3000

actcagcagc tgacctggtc tcgggagtcc ccgcttaaac ccttcttaaa atacagcctg     3060

ggggtgccag gcctgggagt gcacgtgagg cccgacgcca tcagcgtggt tatccggaac     3120

gtctctcaac agatgggggg cttctacctg tgccagccgg ggcccccctc tgagaaggcc     3180

tggcagcctg gctggacagt caatgtggag ggcagcgggg agctgttccg gtggaatgtt     3240

tcggacctag gtggcctggg ctgtggcctg aagaacaggt cctcagaggg ccccagctcc     3300

ccttccggga agctcatgag ccccaagctg tatgtgtggg ccaaagaccg ccctgagatc     3360

tgggagggag agcctccgtg tctcccaccg agggacagcc tgaaccagag cctcagccgg     3420

gacctcaccg ttgcccctgg ctccacactc tggctgtcct gtggggtacc ccctgactct     3480

gtgtccaggg gccccctctc ctggacccat gtgcacccca aggggcctaa gtcattgctg     3540

agcctagagc tgaaggacga tcgcccggcc agagatatgt gggtaatggg cacgagcctg     3600

atgttgcccc gggccacagc tcaagacgct ggaaagtggt attgtcaccg tggcaacctg     3660

accatgtcat tccacctgga gatcactgct cggcca                               3696


<210> 327
<211> 1232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 327
Met Arg Leu Leu Val Leu Leu Trp Gly Cys Leu Leu Leu Pro Gly Tyr 
1               5                   10                  15      


Glu Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
            20                  25                  30          


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
        35                  40                  45              


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
    50                  55                  60                  


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
                85                  90                  95      


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
            100                 105                 110         


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser 
145                 150                 155                 160 


Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp 
            180                 185                 190         


Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu 
        195                 200                 205             


Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe 
    210                 215                 220                 


Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser Ile Glu Val Met Tyr Pro Pro 
            260                 265                 270         


Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys 
        275                 280                 285             


Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
    290                 295                 300                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
305                 310                 315                 320 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                325                 330                 335     


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
            340                 345                 350         


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
        355                 360                 365             


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    370                 375                 380                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
385                 390                 395                 400 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                405                 410                 415     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
            420                 425                 430         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        435                 440                 445             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
    450                 455                 460                 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
465                 470                 475                 480 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
                485                 490                 495     


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
            500                 505                 510         


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Arg 
        515                 520                 525             


Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
    530                 535                 540                 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Phe Gly Leu Ser 
545                 550                 555                 560 


Trp Val Phe Leu Val Ala Leu Phe Arg Gly Val Gln Cys Asp Met Ala 
                565                 570                 575     


Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
            580                 585                 590         


Thr Leu Ser Leu Thr Cys Val Val Ser Gly Gly Ser Ile Ser Ser Ser 
        595                 600                 605             


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
    610                 615                 620                 


Ile Gly Glu Ile Tyr His Ser Gly Ser Pro Asp Tyr Asn Pro Ser Leu 
625                 630                 635                 640 


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Arg Asn Gln Phe Ser 
                645                 650                 655     


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
            660                 665                 670         


Ala Lys Val Ser Thr Gly Gly Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
        675                 680                 685             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    690                 695                 700                 


Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr Gln Ser Pro Ser Ser Leu 
705                 710                 715                 720 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
                725                 730                 735     


Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
            740                 745                 750         


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro 
        755                 760                 765             


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
    770                 775                 780                 


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
785                 790                 795                 800 


Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
                805                 810                 815     


Arg Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            820                 825                 830         


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly 
        835                 840                 845             


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly 
    850                 855                 860                 


Ser Ile Arg Ser Ile Asn Val Met Gly Trp Tyr Arg Gln Ala Pro Gly 
865                 870                 875                 880 


Lys Gln Arg Glu Leu Val Ala Ala Cys Ala Ser Asp Gly Asn Thr Tyr 
                885                 890                 895     


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
            900                 905                 910         


Glu Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr 
        915                 920                 925             


Ala Val Tyr Tyr Cys Asp Ala Asn Ser Arg Gly Asn Tyr Tyr Ser Gly 
    930                 935                 940                 


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
945                 950                 955                 960 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Glu Glu 
                965                 970                 975     


Pro Leu Val Val Lys Val Glu Glu Gly Asp Thr Ala Ala Leu Trp Cys 
            980                 985                 990         


Leu Lys Gly Thr Ser Asp Gly Pro  Thr Gln Gln Leu Thr  Trp Ser Arg 
        995                 1000                 1005             


Glu Ser  Pro Leu Lys Pro Phe  Leu Lys Tyr Ser Leu  Gly Val Pro 
    1010                 1015                 1020             


Gly Leu  Gly Val His Val Arg  Pro Asp Ala Ile Ser  Val Val Ile 
    1025                 1030                 1035             


Arg Asn  Val Ser Gln Gln Met  Gly Gly Phe Tyr Leu  Cys Gln Pro 
    1040                 1045                 1050             


Gly Pro  Pro Ser Glu Lys Ala  Trp Gln Pro Gly Trp  Thr Val Asn 
    1055                 1060                 1065             


Val Glu  Gly Ser Gly Glu Leu  Phe Arg Trp Asn Val  Ser Asp Leu 
    1070                 1075                 1080             


Gly Gly  Leu Gly Cys Gly Leu  Lys Asn Arg Ser Ser  Glu Gly Pro 
    1085                 1090                 1095             


Ser Ser  Pro Ser Gly Lys Leu  Met Ser Pro Lys Leu  Tyr Val Trp 
    1100                 1105                 1110             


Ala Lys  Asp Arg Pro Glu Ile  Trp Glu Gly Glu Pro  Pro Cys Leu 
    1115                 1120                 1125             


Pro Pro  Arg Asp Ser Leu Asn  Gln Ser Leu Ser Arg  Asp Leu Thr 
    1130                 1135                 1140             


Val Ala  Pro Gly Ser Thr Leu  Trp Leu Ser Cys Gly  Val Pro Pro 
    1145                 1150                 1155             


Asp Ser  Val Ser Arg Gly Pro  Leu Ser Trp Thr His  Val His Pro 
    1160                 1165                 1170             


Lys Gly  Pro Lys Ser Leu Leu  Ser Leu Glu Leu Lys  Asp Asp Arg 
    1175                 1180                 1185             


Pro Ala  Arg Asp Met Trp Val  Met Gly Thr Ser Leu  Met Leu Pro 
    1190                 1195                 1200             


Arg Ala  Thr Ala Gln Asp Ala  Gly Lys Trp Tyr Cys  His Arg Gly 
    1205                 1210                 1215             


Asn Leu  Thr Met Ser Phe His  Leu Glu Ile Thr Ala  Arg Pro 
    1220                 1225                 1230         


<210> 328
<211> 275
<212> PRT
<213> Homo sapiens

<400> 328
Met Trp Ile Asp Phe Phe Thr Tyr Ser Ser Met Ser Glu Glu Val Thr 
1               5                   10                  15      


Tyr Ala Asp Leu Gln Phe Gln Asn Ser Ser Glu Met Glu Lys Ile Pro 
            20                  25                  30          


Glu Ile Gly Lys Phe Gly Glu Lys Ala Pro Pro Ala Pro Ser His Val 
        35                  40                  45              


Trp Arg Pro Ala Ala Leu Phe Leu Thr Leu Leu Cys Leu Leu Leu Leu 
    50                  55                  60                  


Ile Gly Leu Gly Val Leu Ala Ser Met Phe His Val Thr Leu Lys Ile 
65                  70                  75                  80  


Glu Met Lys Lys Met Asn Lys Leu Gln Asn Ile Ser Glu Glu Leu Gln 
                85                  90                  95      


Arg Asn Ile Ser Leu Gln Leu Met Ser Asn Met Asn Ile Ser Asn Lys 
            100                 105                 110         


Ile Arg Asn Leu Ser Thr Thr Leu Gln Thr Ile Ala Thr Lys Leu Cys 
        115                 120                 125             


Arg Glu Leu Tyr Ser Lys Glu Gln Glu His Lys Cys Lys Pro Cys Pro 
    130                 135                 140                 


Arg Arg Trp Ile Trp His Lys Asp Ser Cys Tyr Phe Leu Ser Asp Asp 
145                 150                 155                 160 


Val Gln Thr Trp Gln Glu Ser Lys Met Ala Cys Ala Ala Gln Asn Ala 
                165                 170                 175     


Ser Leu Leu Lys Ile Asn Asn Lys Asn Ala Leu Glu Phe Ile Lys Ser 
            180                 185                 190         


Gln Ser Arg Ser Tyr Asp Tyr Trp Leu Gly Leu Ser Pro Glu Glu Asp 
        195                 200                 205             


Ser Thr Arg Gly Met Arg Val Asp Asn Ile Ile Asn Ser Ser Ala Trp 
    210                 215                 220                 


Val Ile Arg Asn Ala Pro Asp Leu Asn Asn Met Tyr Cys Gly Tyr Ile 
225                 230                 235                 240 


Asn Arg Leu Tyr Val Gln Tyr Tyr His Cys Thr Tyr Lys Lys Arg Met 
                245                 250                 255     


Ile Cys Glu Lys Met Ala Asn Pro Val Gln Leu Gly Ser Thr Tyr Phe 
            260                 265                 270         


Arg Glu Ala 
        275 


<210> 329
<211> 275
<212> PRT
<213> Homo sapiens

<400> 329
Met Trp Ile Asp Phe Phe Thr Tyr Ser Ser Met Ser Glu Glu Val Thr 
1               5                   10                  15      


Tyr Ala Asp Leu Gln Phe Gln Asn Ser Ser Glu Met Glu Lys Ile Pro 
            20                  25                  30          


Glu Ile Gly Lys Phe Gly Glu Lys Ala Pro Pro Ala Pro Ser His Val 
        35                  40                  45              


Trp Arg Pro Ala Ala Leu Phe Leu Thr Leu Leu Cys Leu Leu Leu Leu 
    50                  55                  60                  


Ile Gly Leu Gly Val Leu Ala Ser Met Phe His Val Thr Leu Lys Ile 
65                  70                  75                  80  


Glu Met Lys Lys Met Asn Lys Leu Gln Asn Ile Ser Glu Glu Leu Gln 
                85                  90                  95      


Arg Asn Ile Ser Leu Gln Leu Met Ser Asn Met Asn Ile Ser Asn Lys 
            100                 105                 110         


Ile Arg Asn Leu Ser Thr Thr Leu Gln Thr Ile Ala Thr Lys Leu Cys 
        115                 120                 125             


Arg Glu Leu Tyr Ser Lys Glu Gln Glu His Lys Cys Lys Pro Cys Pro 
    130                 135                 140                 


Arg Arg Trp Ile Trp His Lys Asp Ser Cys Tyr Phe Leu Ser Asp Asp 
145                 150                 155                 160 


Val Gln Thr Trp Gln Glu Ser Lys Met Ala Cys Ala Ala Gln Asn Ala 
                165                 170                 175     


Ser Leu Leu Lys Ile Asn Asn Lys Asn Ala Leu Glu Phe Ile Lys Ser 
            180                 185                 190         


Gln Ser Arg Ser Tyr Asp Tyr Trp Leu Gly Leu Ser Pro Glu Glu Asp 
        195                 200                 205             


Ser Thr Arg Gly Met Arg Val Asp Asn Ile Ile Asn Ser Ser Ala Trp 
    210                 215                 220                 


Val Ile Arg Asn Ala Pro Asp Leu Asn Asn Met Tyr Cys Gly Tyr Ile 
225                 230                 235                 240 


Asn Arg Leu Tyr Val Gln Tyr Tyr His Cys Thr Tyr Lys Gln Arg Met 
                245                 250                 255     


Ile Cys Glu Lys Met Ala Asn Pro Val Gln Leu Gly Ser Thr Tyr Phe 
            260                 265                 270         


Arg Glu Ala 
        275 


<210> 330
<211> 1239
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 330
atggagtttg ggctgagctg ggttttcctc gttgctcttt ttagaggtgt ccagtgtcag       60

gtgcagctgc aggagtctgg gggaggcttg gtgcaggctg gggggtccct tagactctcc      120

tgtgtagcct ctggaagcat cagaagtatc aatgtcatgg gctggtaccg ccaggctcca      180

gggaagcagc gcgagttggt cgcagcttgt gctagtgatg gcaacacata ctatgcggac      240

tccgtgaagg gccgattcac catctccaga gacaacgccg agaaaacggt gtatctgcag      300

atgaacaacc tgaaacctga cgacacagcc gtctattact gtgatgcgaa ttcgaggggg      360

aattattatt cgggccaggg gacccaggtc accgtttcct caactagtgg cccgggaggc      420

caaggcgcag actacaaaga cgatgacgac aagattgaag ttatgtatcc tcctccttac      480

ctagacaatg agaagagcaa tggaaccatt atccatgtga aagggaaaca cctttgtcca      540

agtcccctat ttcccggacc ttctaagccc ttttgggtgc tggtggtggt tggtggagtc      600

ctggcttgct atagcttgct agtaacagtg gcctttatta ttttctgggt ccgcagtaag      660

aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc      720

cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctccaaacgg      780

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact      840

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg      900

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc      960

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1020

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac     1080

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1140

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1200

acctacgacg cccttcacat gcaagccctg ccccctcgc                            1239


<210> 331
<211> 413
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 331
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Ile Arg 
        35                  40                  45              


Ser Ile Asn Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
    50                  55                  60                  


Glu Leu Val Ala Ala Cys Ala Ser Asp Gly Asn Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Lys Thr 
                85                  90                  95      


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Asp Ala Asn Ser Arg Gly Asn Tyr Tyr Ser Gly Gln Gly Thr 
        115                 120                 125             


Gln Val Thr Val Ser Ser Thr Ser Gly Pro Gly Gly Gln Gly Ala Asp 
    130                 135                 140                 


Tyr Lys Asp Asp Asp Asp Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr 
145                 150                 155                 160 


Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys 
                165                 170                 175     


His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp 
            180                 185                 190         


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
        195                 200                 205             


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
    210                 215                 220                 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
225                 230                 235                 240 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
                245                 250                 255     


Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            260                 265                 270         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        275                 280                 285             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    290                 295                 300                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
305                 310                 315                 320 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                325                 330                 335     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
            340                 345                 350         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        355                 360                 365             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    370                 375                 380                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
385                 390                 395                 400 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                405                 410             


<210> 332
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 332
Thr Ser Gly Pro Gly Gly Gln Gly Ala 
1               5                   


<210> 333
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 333
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 334
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 334
His His His His His His 
1               5       


<210> 335
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 335
Thr Ser Gly Pro Gly Gly Gln Gly Ala Glu Gln Lys Leu Ile Ser Glu 
1               5                   10                  15      


Glu Asp Leu Gly Ala His His His His His His Gly Ala Ser 
            20                  25                  30  


<210> 336
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 336
Cys Ala Ala Ser Gly Ser Ile Phe Ala Ile Asn Glu Ile 
1               5                   10              


<210> 337
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 337
Cys Val Val Ser Gly Asp Thr Arg Ser Ile 
1               5                   10  


<210> 338
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 338
Cys Val Ala Ser Gly Ser Ile Arg Ser Ile 
1               5                   10  


<210> 339
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 339
Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr Ala 
1               5                   10          


<210> 340
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 340
Cys Ala Ala Ser Gly Leu Thr Phe Ser Asn Tyr Ala 
1               5                   10          


<210> 341
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 341
Cys Ala Ala Ser Gly Phe Ala Phe Asp Asp Tyr Ala 
1               5                   10          


<210> 342
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 342
Cys Val Val Ser Gly Ala Thr Ser Asn Val Asn Ala 
1               5                   10          


<210> 343
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 343
Cys Val Val Ser Gly Thr Met Phe Ser Gly Lys Asp 
1               5                   10          


<210> 344
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 344
Cys Val Ala Ser Gly Asn Asp Ile Ser Gly Ser Ala 
1               5                   10          


<210> 345
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 345
Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn Ala 
1               5                   10          


<210> 346
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 346
Cys Val Val Ser Gly Asn Met Leu Asp Leu Asn Thr 
1               5                   10          


<210> 347
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 347
Gly Ser Asp Arg Ser Ile Asn Val 
1               5               


<210> 348
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 348
Gly Arg Thr Ile Asp Asn Gly Ala 
1               5               


<210> 349
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 349
Val Ala Ala Cys Ala Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210> 350
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 350
Trp Val Ser Asp Ile Asn Ser Gly Gly Gly Ser Thr Asn 
1               5                   10              


<210> 351
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 351
Ala Ile Asn Trp Ser Gly Gly Thr Thr Asp 
1               5                   10  


<210> 352
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 352
Trp Val Ser Ser Ile Ser Trp Asn Gly Gly Gly Thr Tyr 
1               5                   10              


<210> 353
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 353
Leu Val Ala Ala Ile Ser Ser Gly Gly Ser Thr Ser 
1               5                   10          


<210> 354
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 354
Val Ala Thr Val Ser Ser Asp Gly Gly Thr Asp 
1               5                   10      


<210> 355
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 355
Val Ala Val Asp Ala Pro Arg Glu Arg Pro Phe 
1               5                   10      


<210> 356
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 356
Val Ala Val Val Ser Arg Phe Gly Glu Thr Thr 
1               5                   10      


<210> 357
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 357
Leu Val Ala Ala Leu Gly Ile Ser Thr Tyr 
1               5                   10  


<210> 358
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 358
Ile Thr Ser Gly Gly Thr Thr 
1               5           


<210> 359
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 359
Ile Asn Trp Ser Gly Gly Ala Thr 
1               5               


<210> 360
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 360
Asp Ala Asn Ser Arg Gly Asn Tyr Tyr 
1               5                   


<210> 361
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 361
Ala Thr Glu Leu Arg Gly Ser Asp Tyr Tyr Arg Gly Pro Ile Arg Glu 
1               5                   10                  15      


Tyr Ala Tyr 
            


<210> 362
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 362
Ala Ala Ser Tyr Arg Leu Arg Ile Thr Val Val Val Thr Pro Asp Glu 
1               5                   10                  15      


Tyr His Tyr 
            


<210> 363
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 363
Val Lys Leu Val Asp Ser Gly Trp Tyr Ser Ala Tyr Asp Tyr 
1               5                   10                  


<210> 364
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 364
Ala Ala Gln Asp Trp Ala Thr Glu Gly Tyr Glu Tyr Asp Tyr 
1               5                   10                  


<210> 365
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 365
His Phe Leu Trp Gly Arg His Tyr 
1               5               


<210> 366
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 366
Gly Pro Ser Leu Arg Thr Phe His Gly Arg Glu Trp Tyr Arg Pro Pro 
1               5                   10                  15      


Trp Phe Thr Ser 
            20  


<210> 367
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 367
Asn Ala Arg Ile Arg Gly Asn Tyr Gly Ser Arg Ile Asp Tyr 
1               5                   10                  


<210> 368
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 368
Ala Arg Asp Tyr Asn Phe Glu Ser 
1               5               


<210> 369
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 369
Lys Ala Asp Thr Arg Trp Gly Gly Met Tyr 
1               5                   10  


<210> 370
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 370
Ala Ser Arg Arg Gly Val Asp Leu Arg Arg Asn Ser Tyr Glu Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210> 371
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 371
Gly Ser Ile Phe Ala Ile Asn Glu Ile Asn Leu 
1               5                   10      


<210> 372
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 372
Gly Asp Thr Arg Ser Ile Asn Leu 
1               5               


<210> 373
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 373
Gly Ser Ile Arg Ser Ile Asn Val 
1               5               


<210> 374
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 374
Gly Phe Thr Phe Asn Ser Tyr Ala 
1               5               


<210> 375
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 375
Gly Leu Thr Phe Ser Asn Tyr Ala 
1               5               


<210> 376
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 376
Gly Phe Ala Phe Asp Asp Tyr Ala 
1               5               


<210> 377
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 377
Gly Ala Thr Ser Asn Val Asn Ala 
1               5               


<210> 378
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 378
Gly Thr Met Phe Ser Gly Lys Asp 
1               5               


<210> 379
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 379
Gly Asn Asp Ile Ser Gly Ser Ala 
1               5               


<210> 380
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 380
Gly Ser Ile Phe Ser Ile Asn Ala 
1               5               


<210> 381
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 381
Gly Asn Met Leu Asp Leu Asn Thr 
1               5               


<210> 382
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 382
Cys Ala Ser Asp Gly Asn Thr 
1               5           


<210> 383
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 383
Ile Asn Ser Gly Gly Gly Ser Thr 
1               5               


<210> 384
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 384
Ile Asn Trp Ser Gly Gly Thr Thr 
1               5               


<210> 385
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 385
Ile Ser Trp Asn Gly Gly Gly Thr 
1               5               


<210> 386
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 386
Ile Ser Ser Gly Gly Ser Thr 
1               5           


<210> 387
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 387
Val Ser Ser Asp Gly Gly Thr 
1               5           


<210> 388
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 388
Val Asp Ala Pro Arg Glu Arg Pro 
1               5               


<210> 389
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 389
Val Ser Arg Phe Gly Glu Thr 
1               5           


<210> 390
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 390
Leu Gly Ile Ser Thr 
1               5   


