                         SEQUENCE LISTING

<110>  Celgene Corporation
       Vu, Minh Diem
       Cho, Younhee
 
<120>  OPTIMIZED SPECIES

<130>  298068-00325

<150>  US 62/838,660
<151>  2019-04-25

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC anti-BCMA VH/anti-CD3 VL crossmab

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asn 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Pro Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Leu Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Glu Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Glu Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu 
225                 230                 235                 240 


Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr 
                245                 250                 255     


Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro 
            260                 265                 270         


Gly Gln Ala Phe Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro 
        275                 280                 285             


Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
    290                 295                 300                 


Leu Thr Leu Ser Gly Ala Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
305                 310                 315                 320 


Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu 
                325                 330                 335     


Thr Val Leu Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
            340                 345                 350         


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
        355                 360                 365             


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
    370                 375                 380                 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
385                 390                 395                 400 


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                405                 410                 415     


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
            420                 425                 430         


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
        435                 440                 445             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
    450                 455                 460                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
465                 470                 475                 480 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                485                 490                 495     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            500                 505                 510         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        515                 520                 525             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    530                 535                 540                 


Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile 
545                 550                 555                 560 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                565                 570                 575     


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
            580                 585                 590         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        595                 600                 605             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    610                 615                 620                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
625                 630                 635                 640 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                645                 650                 655     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 665                 670     


<210>  2
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC'' anti-CD3 VH/Kappa crossmab

<400>  2

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230         


<210>  3
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC' anti-BCMA

<400>  3

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asn 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Pro Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Leu Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Glu Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Glu Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  4
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC''' and LC''''' anti-BCMA

<400>  4

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asp Glu 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile His Ser Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ala Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Tyr Pro Pro 
                85                  90                  95      


Asp Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Arg Lys Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  5
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC anti-BCMA VH/anti-CD3 VL crossmab with signal

<400>  5

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Asn Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Ser Gly Pro Gly Ser Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Val Leu Gly Trp Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    130                 135                 140                 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
145                 150                 155                 160 


Gly Cys Leu Val Glu Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        195                 200                 205             


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
    210                 215                 220                 


Ser Asn Thr Lys Val Asp Glu Lys Val Glu Pro Lys Ser Cys Asp Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu 
                245                 250                 255     


Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
            260                 265                 270         


Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln 
        275                 280                 285             


Glu Lys Pro Gly Gln Ala Phe Arg Gly Leu Ile Gly Gly Thr Asn Lys 
    290                 295                 300                 


Arg Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
305                 310                 315                 320 


Lys Ala Ala Leu Thr Leu Ser Gly Ala Gln Pro Glu Asp Glu Ala Glu 
                325                 330                 335     


Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly 
            340                 345                 350         


Thr Lys Leu Thr Val Leu Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        355                 360                 365             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    370                 375                 380                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
385                 390                 395                 400 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                405                 410                 415     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            420                 425                 430         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        435                 440                 445             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    450                 455                 460                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
465                 470                 475                 480 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                485                 490                 495     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            500                 505                 510         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        515                 520                 525             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    530                 535                 540                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
545                 550                 555                 560 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu 
                565                 570                 575     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            580                 585                 590         


Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        595                 600                 605             


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    610                 615                 620                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
625                 630                 635                 640 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                645                 650                 655     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            660                 665                 670         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        675                 680                 685             


Gly Lys 
    690 


<210>  6
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC'' anti-CD3 VH/Kappa crossmab with signal

<400>  6

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val 
        115                 120                 125             


Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
145                 150                 155                 160 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
                165                 170                 175     


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
            180                 185                 190         


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
        195                 200                 205             


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
    210                 215                 220                 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
225                 230                 235                 240 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                245                 250     


<210>  7
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC' anti-BCMA with signal

<400>  7

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Asn Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Ser Gly Pro Gly Ser Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Val Leu Gly Trp Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    130                 135                 140                 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
145                 150                 155                 160 


Gly Cys Leu Val Glu Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        195                 200                 205             


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
    210                 215                 220                 


Ser Asn Thr Lys Val Asp Glu Lys Val Glu Pro Lys Ser Cys Asp Lys 
225                 230                 235                 240 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
        355                 360                 365             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser 
    370                 375                 380                 


Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460                 


Lys 
465 


<210>  8
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC''' and LC'''' anti-BCMA with signal

<400>  8

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu 
            20                  25                  30          


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        35                  40                  45              


Ser Asp Glu Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile His Ser Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ala Ile Ser 
                85                  90                  95      


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly 
            100                 105                 110         


Tyr Pro Pro Asp Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Arg 
    130                 135                 140                 


Lys Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA CDRH1 CC-93269

<400>  9

Asp Asn Ala Met Gly 
1               5   


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA CDRH2 CC-93269

<400>  10

Ala Ile Ser Gly Pro Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA CDRH3 CC-93269

<400>  11

Val Leu Gly Trp Phe Asp Tyr 
1               5           


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA CDRL1 CC-93269

<400>  12

Arg Ala Ser Gln Ser Val Ser Asp Glu Tyr Leu Ser 
1               5                   10          


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA CDRL2 CC-93269

<400>  13

Ser Ala Ser Thr Arg Ala Thr 
1               5           


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA CDRL3 CC-93269

<400>  14

Gln Gln Tyr Gly Tyr Pro Pro Asp Phe Thr 
1               5                   10  


<210>  15
<211>  2171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC anti-BCMA VH/anti-CD3 VL crossmab whole precursor DNA

<400>  15
cactataggg cgaattgaag gaaggccgtc aaggccgcat aagcttgcca ccatgggctg       60

gtcctgcatc atcctgtttc tggtggctac cgccaccggt gtgcattccg aggtgcagct      120

gctggaatct ggcggcggac tggtgcagcc tggcggatct ctgagactgt cttgtgccgc      180

ctccggcttc accttctccg acaacgctat gggctgggtg cgacaggctc ctggcaaggg      240

actggaatgg gtgtccgcca tctccggccc tggctcctct acctactacg ccgactccgt      300

gaagggccgg ttcaccatct cccgggacaa ctccaagaac accctgtacc tgcagatgaa      360

ctccctgcgg gccgaggaca ccgccgtgta ctactgtgct aaggtgctgg gatggttcga      420

ctactggggc cagggcaccc tcgtgaccgt gtcctctgct agcaccaagg gcccctccgt      480

gtttcctctg gccccttcca gcaagtccac ctctggcgga acagccgctc tgggctgcct      540

ggtggaagat tacttccccg agcccgtgac agtgtcttgg aactctggcg ccctgacctc      600

cggcgtgcac acctttccag ctgtgctgca gtcctccggc ctgtactccc tgtcctccgt      660

cgtgactgtg ccctccagct ctctgggcac ccagacctac atctgcaacg tgaaccacaa      720

gccctccaac accaaggtgg acgagaaggt ggaacccaag tcctgcgacg gcggaggcgg      780

atcaggtggc ggaggatctc aggctgtcgt gacccaggaa ccctccctga ctgtgtctcc      840

tggcggcacc gtgaccctga cctgtggatc ttctaccggc gctgtgacca cctccaacta      900

cgccaactgg gtgcaggaaa agcccggcca ggccttcaga ggactgatcg gcggcaccaa      960

caagagagcc cctggcaccc ctgccagatt ctccggttct ctgctgggcg gcaaggccgc     1020

tctgactctg tctggtgctc agcctgagga cgaggctgag tactactgcg ccctgtggta     1080

ctccaacctg tgggtgttcg gcggtggcac caagctgacc gtgctgtcca gcgcttccac     1140

caagggaccc agtgtgttcc cactggcccc cagctccaag tctacatccg gcggtactgc     1200

tgccctggga tgtctcgtga aggactactt tcctgagcct gtgaccgtgt catggaatag     1260

cggcgctctg acaagcggag tgcatacctt ccctgccgtg ctgcagagca gcggcctgta     1320

tagcctgagc agcgtcgtga ccgtgccttc ctctagcctg ggcacacaga catatatctg     1380

taatgtgaat cataagccca gtaataccaa agtggataag aaagtggaac ctaagagctg     1440

cgataagacc cacacctgtc ccccctgtcc tgcccctgaa gctgctggtg gccctagcgt     1500

gttcctgttc cccccaaagc ctaaggacac cctgatgatc tcccggaccc ccgaagtgac     1560

ctgcgtggtg gtggatgtgt cccacgagga ccctgaagtg aagttcaatt ggtacgtgga     1620

cggcgtggaa gtgcacaacg ccaagaccaa gcctagagag gaacagtaca actccaccta     1680

ccgggtggtg tccgtgctga cagtgctgca tcaggactgg ctgaacggca aagagtacaa     1740

gtgcaaggtg tccaacaagg ccctgggcgc tcccatcgaa aagaccatct ccaaggccaa     1800

gggccagccc cgggaacccc aggtgtacac actgccccct tgccgggatg agctgaccaa     1860

gaaccaggtg tccctgtggt gcctcgtgaa aggcttctac ccctccgata tcgccgtgga     1920

atgggagagc aacggccagc ccgagaacaa ctataagacc accccccctg tgctggactc     1980

cgacggctca ttcttcctgt acagcaagct gactgtggac aagtcccggt ggcagcaggg     2040

caacgtgttc tcctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc     2100

cctgtccctg agccccggca aatgagaatt cctgggcctc atgggccttc ctttcactgc     2160

ccgctttcca g                                                          2171


<210>  16
<211>  866
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC'' anti-CD3 VH/Kappa crossmab whole precursor DNA

<400>  16
cgaattggcg gaaggccgtc aaggccacgt gtcttgtcca gagctcaagc ttgccaccat       60

gggctggtcc tgcatcatcc tgtttctggt ggctaccgcc accggtgtgc attcggaagt      120

gcagctgctg gaatccggcg gaggactggt gcagcctggc ggatctctga gactgtcttg      180

tgccgcctcc ggcttcacct tctccaccta cgccatgaac tgggtgcgac aggctcctgg      240

caagggcctg gaatgggtgt cccggatcag atccaagtac aacaactacg ccacctacta      300

cgccgactcc gtgaagggcc ggttcaccat ctctcgggac gactccaaga acaccctgta      360

cctgcagatg aactccctgc gggccgagga caccgccgtg tactattgtg tgcggcacgg      420

caacttcggc aactcctatg tgtcttggtt tgcctactgg ggccagggca ccctcgtgac      480

cgtgtcatct gctagcgtgg ccgctccctc cgtgttcatc ttcccacctt ccgacgagca      540

gctgaagtcc ggcaccgctt ctgtcgtgtg cctgctgaac aacttctacc cccgcgaggc      600

caaggtgcag tggaaggtgg acaacgccct gcagtccggc aacagccagg aatccgtgac      660

cgagcaggac tccaaggaca gcacctactc cctgtcctcc accctgaccc tgtccaaggc      720

cgactacgag aagcacaagg tgtacgcctg cgaagtgacc caccagggcc tgtctagccc      780

cgtgaccaag tctttcaacc ggggcgagtg ctgagaattc ggtacctgga gcacaagact      840

ggcctcatgg gccttccgct cactgc                                           866


<210>  17
<211>  1496
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC' anti-BCMA whole precursor DNA

<400>  17
cactataggg cgaattgaag gaaggccgtc aaggccgcat aagcttgcca ccatgggctg       60

gtcctgcatc atcctgtttc tggtggctac cgccaccggt gtgcattccg aggtgcagct      120

gctggaatct ggcggcggac tggtgcagcc tggcggatct ctgagactgt cttgtgccgc      180

ctccggcttc accttctccg acaacgctat gggctgggtg cgacaggctc ctggcaaggg      240

actggaatgg gtgtccgcca tctccggccc tggctcctct acctactacg ccgactccgt      300

gaagggccgg ttcaccatct cccgggacaa ctccaagaac accctgtacc tgcagatgaa      360

ctccctgcgg gccgaggaca ccgccgtgta ctactgtgct aaggtgctgg gatggttcga      420

ctactggggc cagggcaccc tcgtgaccgt gtcctctgct agcaccaagg gcccctccgt      480

gtttcctctg gccccttcca gcaagtccac ctctggcgga acagccgctc tgggctgcct      540

ggtggaagat tacttccccg agcccgtgac agtgtcttgg aactctggcg ccctgacctc      600

cggcgtgcac acctttccag ctgtgctgca gtcctccggc ctgtactccc tgtcctccgt      660

cgtgactgtg ccctccagct ctctgggcac ccagacctac atctgcaacg tgaaccacaa      720

gccctccaac accaaggtgg acgagaaggt ggaacccaag tcctgcgaca agacccacac      780

ctgtccccct tgtcctgccc ctgaagctgc tggcggccct agcgtgttcc tgttcccccc      840

aaagcctaag gacaccctga tgatctcccg gacccccgaa gtgacctgcg tggtggtgga      900

tgtgtcccac gaggaccctg aagtgaagtt caattggtac gtggacggcg tggaagtgca      960

caacgccaag accaagccta gagaggaaca gtacaactcc acctaccggg tggtgtccgt     1020

gctgaccgtg ctgcatcagg actggctgaa cggcaaagag tacaagtgca aggtgtccaa     1080

caaggccctg ggcgctccca tcgaaaagac catctccaag gccaagggcc agccccggga     1140

acctcaagtg tgcaccctgc cccctagcag ggacgagctg accaagaacc aggtgtccct     1200

gagctgcgct gtgaagggct tctacccctc cgatatcgcc gtggaatggg agagcaacgg     1260

ccagcccgag aacaactata agaccacccc ccctgtgctg gactccgacg gctcattctt     1320

cctggtgtcc aagctgacag tggacaagtc ccggtggcag cagggcaacg tgttctcctg     1380

ctccgtgatg cacgaggccc tgcacaacca ctacacccag aagtccctgt ccctgtctcc     1440

cggcaaatga gaattcctgg gcctcatggg ccttcctttc actgcccgct ttccag         1496


<210>  18
<211>  818
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC''' and LC'''' anti-BCMA whole precursor DNA

<400>  18
cgaattggcg gaaggccgtc aaggccacgt gtcttgtcca gagctcaagc ttgccaccat       60

gggctggtcc tgcatcatcc tgtttctggt ggctaccgcc accggtgtgc attccgaaat      120

cgtgctgacc cagtcccccg gcaccctgtc actgtctcca ggcgagagag ccaccctgtc      180

ctgcagagcc tcccagtccg tgtccgacga gtacctgtcc tggtatcagc agaagcccgg      240

ccaggccccc agactgctga tccactctgc ctctaccaga gccaccggca tccctgacag      300

attctccggc tctggctccg gcaccgattt caccctggcc atctctcggc tggaacccga      360

ggacttcgcc gtgtactact gccagcagta cggctacccc cccgacttca cctttggcca      420

gggcaccaag gtggaaatca agcgtacggt ggccgctccc tccgtgttca tcttccctcc      480

atccgaccgg aagctgaagt ctggcaccgc ctctgtcgtg tgcctgctga acaacttcta      540

cccccgcgag gccaaggtgc agtggaaggt ggacaacgcc ctgcagtccg gcaactccca      600

ggaatccgtg accgagcagg actccaagga cagcacctac tccctgtcct ccaccctgac      660

cctgtccaag gccgactacg agaagcacaa ggtgtacgcc tgcgaagtga cccaccaggg      720

cctgtctagc cccgtgacca agtctttcaa ccggggcgag tgctgagaat tcggtacctg      780

gagcacaaga ctggcctcat gggccttccg ctcactgc                              818


<210>  19
<211>  2073
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC anti-BCMA VH/anti-CD3 VL crossmab coding precursor DNA with 
       signal and termination codon

<400>  19
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccaccggtgt gcattccgag       60

gtgcagctgc tggaatctgg cggcggactg gtgcagcctg gcggatctct gagactgtct      120

tgtgccgcct ccggcttcac cttctccgac aacgctatgg gctgggtgcg acaggctcct      180

ggcaagggac tggaatgggt gtccgccatc tccggccctg gctcctctac ctactacgcc      240

gactccgtga agggccggtt caccatctcc cgggacaact ccaagaacac cctgtacctg      300

cagatgaact ccctgcgggc cgaggacacc gccgtgtact actgtgctaa ggtgctggga      360

tggttcgact actggggcca gggcaccctc gtgaccgtgt cctctgctag caccaagggc      420

ccctccgtgt ttcctctggc cccttccagc aagtccacct ctggcggaac agccgctctg      480

ggctgcctgg tggaagatta cttccccgag cccgtgacag tgtcttggaa ctctggcgcc      540

ctgacctccg gcgtgcacac ctttccagct gtgctgcagt cctccggcct gtactccctg      600

tcctccgtcg tgactgtgcc ctccagctct ctgggcaccc agacctacat ctgcaacgtg      660

aaccacaagc cctccaacac caaggtggac gagaaggtgg aacccaagtc ctgcgacggc      720

ggaggcggat caggtggcgg aggatctcag gctgtcgtga cccaggaacc ctccctgact      780

gtgtctcctg gcggcaccgt gaccctgacc tgtggatctt ctaccggcgc tgtgaccacc      840

tccaactacg ccaactgggt gcaggaaaag cccggccagg ccttcagagg actgatcggc      900

ggcaccaaca agagagcccc tggcacccct gccagattct ccggttctct gctgggcggc      960

aaggccgctc tgactctgtc tggtgctcag cctgaggacg aggctgagta ctactgcgcc     1020

ctgtggtact ccaacctgtg ggtgttcggc ggtggcacca agctgaccgt gctgtccagc     1080

gcttccacca agggacccag tgtgttccca ctggccccca gctccaagtc tacatccggc     1140

ggtactgctg ccctgggatg tctcgtgaag gactactttc ctgagcctgt gaccgtgtca     1200

tggaatagcg gcgctctgac aagcggagtg cataccttcc ctgccgtgct gcagagcagc     1260

ggcctgtata gcctgagcag cgtcgtgacc gtgccttcct ctagcctggg cacacagaca     1320

tatatctgta atgtgaatca taagcccagt aataccaaag tggataagaa agtggaacct     1380

aagagctgcg ataagaccca cacctgtccc ccctgtcctg cccctgaagc tgctggtggc     1440

cctagcgtgt tcctgttccc cccaaagcct aaggacaccc tgatgatctc ccggaccccc     1500

gaagtgacct gcgtggtggt ggatgtgtcc cacgaggacc ctgaagtgaa gttcaattgg     1560

tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ctagagagga acagtacaac     1620

tccacctacc gggtggtgtc cgtgctgaca gtgctgcatc aggactggct gaacggcaaa     1680

gagtacaagt gcaaggtgtc caacaaggcc ctgggcgctc ccatcgaaaa gaccatctcc     1740

aaggccaagg gccagccccg ggaaccccag gtgtacacac tgcccccttg ccgggatgag     1800

ctgaccaaga accaggtgtc cctgtggtgc ctcgtgaaag gcttctaccc ctccgatatc     1860

gccgtggaat gggagagcaa cggccagccc gagaacaact ataagaccac cccccctgtg     1920

ctggactccg acggctcatt cttcctgtac agcaagctga ctgtggacaa gtcccggtgg     1980

cagcagggca acgtgttctc ctgctccgtg atgcacgagg ccctgcacaa ccactacacc     2040

cagaagtccc tgtccctgag ccccggcaaa tga                                  2073


<210>  20
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC'' anti-CD3 VH/Kappa crossmab coding precursor DNA with signal 
       and termination codon

<400>  20
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccaccggtgt gcattcggaa       60

gtgcagctgc tggaatccgg cggaggactg gtgcagcctg gcggatctct gagactgtct      120

tgtgccgcct ccggcttcac cttctccacc tacgccatga actgggtgcg acaggctcct      180

ggcaagggcc tggaatgggt gtcccggatc agatccaagt acaacaacta cgccacctac      240

tacgccgact ccgtgaaggg ccggttcacc atctctcggg acgactccaa gaacaccctg      300

tacctgcaga tgaactccct gcgggccgag gacaccgccg tgtactattg tgtgcggcac      360

ggcaacttcg gcaactccta tgtgtcttgg tttgcctact ggggccaggg caccctcgtg      420

accgtgtcat ctgctagcgt ggccgctccc tccgtgttca tcttcccacc ttccgacgag      480

cagctgaagt ccggcaccgc ttctgtcgtg tgcctgctga acaacttcta cccccgcgag      540

gccaaggtgc agtggaaggt ggacaacgcc ctgcagtccg gcaacagcca ggaatccgtg      600

accgagcagg actccaagga cagcacctac tccctgtcct ccaccctgac cctgtccaag      660

gccgactacg agaagcacaa ggtgtacgcc tgcgaagtga cccaccaggg cctgtctagc      720

cccgtgacca agtctttcaa ccggggcgag tgctga                                756


<210>  21
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC' anti-BCMA coding precursor DNA with signal and termination 
       codon

<400>  21
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccaccggtgt gcattccgag       60

gtgcagctgc tggaatctgg cggcggactg gtgcagcctg gcggatctct gagactgtct      120

tgtgccgcct ccggcttcac cttctccgac aacgctatgg gctgggtgcg acaggctcct      180

ggcaagggac tggaatgggt gtccgccatc tccggccctg gctcctctac ctactacgcc      240

gactccgtga agggccggtt caccatctcc cgggacaact ccaagaacac cctgtacctg      300

cagatgaact ccctgcgggc cgaggacacc gccgtgtact actgtgctaa ggtgctggga      360

tggttcgact actggggcca gggcaccctc gtgaccgtgt cctctgctag caccaagggc      420

ccctccgtgt ttcctctggc cccttccagc aagtccacct ctggcggaac agccgctctg      480

ggctgcctgg tggaagatta cttccccgag cccgtgacag tgtcttggaa ctctggcgcc      540

ctgacctccg gcgtgcacac ctttccagct gtgctgcagt cctccggcct gtactccctg      600

tcctccgtcg tgactgtgcc ctccagctct ctgggcaccc agacctacat ctgcaacgtg      660

aaccacaagc cctccaacac caaggtggac gagaaggtgg aacccaagtc ctgcgacaag      720

acccacacct gtcccccttg tcctgcccct gaagctgctg gcggccctag cgtgttcctg      780

ttccccccaa agcctaagga caccctgatg atctcccgga cccccgaagt gacctgcgtg      840

gtggtggatg tgtcccacga ggaccctgaa gtgaagttca attggtacgt ggacggcgtg      900

gaagtgcaca acgccaagac caagcctaga gaggaacagt acaactccac ctaccgggtg      960

gtgtccgtgc tgaccgtgct gcatcaggac tggctgaacg gcaaagagta caagtgcaag     1020

gtgtccaaca aggccctggg cgctcccatc gaaaagacca tctccaaggc caagggccag     1080

ccccgggaac ctcaagtgtg caccctgccc cctagcaggg acgagctgac caagaaccag     1140

gtgtccctga gctgcgctgt gaagggcttc tacccctccg atatcgccgt ggaatgggag     1200

agcaacggcc agcccgagaa caactataag accacccccc ctgtgctgga ctccgacggc     1260

tcattcttcc tggtgtccaa gctgacagtg gacaagtccc ggtggcagca gggcaacgtg     1320

ttctcctgct ccgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgtcc     1380

ctgtctcccg gcaaatga                                                   1398


<210>  22
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC''' and LC'''' anti-BCMA coding precursor DNA with signal and 
       termination codon

<400>  22
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccaccggtgt gcattccgaa       60

atcgtgctga cccagtcccc cggcaccctg tcactgtctc caggcgagag agccaccctg      120

tcctgcagag cctcccagtc cgtgtccgac gagtacctgt cctggtatca gcagaagccc      180

ggccaggccc ccagactgct gatccactct gcctctacca gagccaccgg catccctgac      240

agattctccg gctctggctc cggcaccgat ttcaccctgg ccatctctcg gctggaaccc      300

gaggacttcg ccgtgtacta ctgccagcag tacggctacc cccccgactt cacctttggc      360

cagggcacca aggtggaaat caagcgtacg gtggccgctc cctccgtgtt catcttccct      420

ccatccgacc ggaagctgaa gtctggcacc gcctctgtcg tgtgcctgct gaacaacttc      480

tacccccgcg aggccaaggt gcagtggaag gtggacaacg ccctgcagtc cggcaactcc      540

caggaatccg tgaccgagca ggactccaag gacagcacct actccctgtc ctccaccctg      600

accctgtcca aggccgacta cgagaagcac aaggtgtacg cctgcgaagt gacccaccag      660

ggcctgtcta gccccgtgac caagtctttc aaccggggcg agtgctga                   708


<210>  23
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA VH CC-93269

<400>  23

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asn 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Pro Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Leu Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  24
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA VL CC-93269

<400>  24

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asp Glu 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile His Ser Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ala Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Tyr Pro Pro 
                85                  90                  95      


Asp Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  25
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 VH

<400>  25

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  26
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 VL

<400>  26

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  27
<211>  2013
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC anti-BCMA VH/anti-CD3 VL crossmab coding DNA

<400>  27
gaggtgcagc tgctggaatc tggcggcgga ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc gacaacgcta tgggctgggt gcgacaggct      120

cctggcaagg gactggaatg ggtgtccgcc atctccggcc ctggctcctc tacctactac      180

gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc taaggtgctg      300

ggatggttcg actactgggg ccagggcacc ctcgtgaccg tgtcctctgc tagcaccaag      360

ggcccctccg tgtttcctct ggccccttcc agcaagtcca cctctggcgg aacagccgct      420

ctgggctgcc tggtggaaga ttacttcccc gagcccgtga cagtgtcttg gaactctggc      480

gccctgacct ccggcgtgca cacctttcca gctgtgctgc agtcctccgg cctgtactcc      540

ctgtcctccg tcgtgactgt gccctccagc tctctgggca cccagaccta catctgcaac      600

gtgaaccaca agccctccaa caccaaggtg gacgagaagg tggaacccaa gtcctgcgac      660

ggcggaggcg gatcaggtgg cggaggatct caggctgtcg tgacccagga accctccctg      720

actgtgtctc ctggcggcac cgtgaccctg acctgtggat cttctaccgg cgctgtgacc      780

acctccaact acgccaactg ggtgcaggaa aagcccggcc aggccttcag aggactgatc      840

ggcggcacca acaagagagc ccctggcacc cctgccagat tctccggttc tctgctgggc      900

ggcaaggccg ctctgactct gtctggtgct cagcctgagg acgaggctga gtactactgc      960

gccctgtggt actccaacct gtgggtgttc ggcggtggca ccaagctgac cgtgctgtcc     1020

agcgcttcca ccaagggacc cagtgtgttc ccactggccc ccagctccaa gtctacatcc     1080

ggcggtactg ctgccctggg atgtctcgtg aaggactact ttcctgagcc tgtgaccgtg     1140

tcatggaata gcggcgctct gacaagcgga gtgcatacct tccctgccgt gctgcagagc     1200

agcggcctgt atagcctgag cagcgtcgtg accgtgcctt cctctagcct gggcacacag     1260

acatatatct gtaatgtgaa tcataagccc agtaatacca aagtggataa gaaagtggaa     1320

cctaagagct gcgataagac ccacacctgt cccccctgtc ctgcccctga agctgctggt     1380

ggccctagcg tgttcctgtt ccccccaaag cctaaggaca ccctgatgat ctcccggacc     1440

cccgaagtga cctgcgtggt ggtggatgtg tcccacgagg accctgaagt gaagttcaat     1500

tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcctagaga ggaacagtac     1560

aactccacct accgggtggt gtccgtgctg acagtgctgc atcaggactg gctgaacggc     1620

aaagagtaca agtgcaaggt gtccaacaag gccctgggcg ctcccatcga aaagaccatc     1680

tccaaggcca agggccagcc ccgggaaccc caggtgtaca cactgccccc ttgccgggat     1740

gagctgacca agaaccaggt gtccctgtgg tgcctcgtga aaggcttcta cccctccgat     1800

atcgccgtgg aatgggagag caacggccag cccgagaaca actataagac caccccccct     1860

gtgctggact ccgacggctc attcttcctg tacagcaagc tgactgtgga caagtcccgg     1920

tggcagcagg gcaacgtgtt ctcctgctcc gtgatgcacg aggccctgca caaccactac     1980

acccagaagt ccctgtccct gagccccggc aaa                                  2013


<210>  28
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC'' anti-CD3 VH/Kappa crossmab coding DNA

<400>  28
gaagtgcagc tgctggaatc cggcggagga ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc acctacgcca tgaactgggt gcgacaggct      120

cctggcaagg gcctggaatg ggtgtcccgg atcagatcca agtacaacaa ctacgccacc      180

tactacgccg actccgtgaa gggccggttc accatctctc gggacgactc caagaacacc      240

ctgtacctgc agatgaactc cctgcgggcc gaggacaccg ccgtgtacta ttgtgtgcgg      300

cacggcaact tcggcaactc ctatgtgtct tggtttgcct actggggcca gggcaccctc      360

gtgaccgtgt catctgctag cgtggccgct ccctccgtgt tcatcttccc accttccgac      420

gagcagctga agtccggcac cgcttctgtc gtgtgcctgc tgaacaactt ctacccccgc      480

gaggccaagg tgcagtggaa ggtggacaac gccctgcagt ccggcaacag ccaggaatcc      540

gtgaccgagc aggactccaa ggacagcacc tactccctgt cctccaccct gaccctgtcc      600

aaggccgact acgagaagca caaggtgtac gcctgcgaag tgacccacca gggcctgtct      660

agccccgtga ccaagtcttt caaccggggc gagtgc                                696


<210>  29
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC' Coding DNA

<400>  29
gaggtgcagc tgctggaatc tggcggcgga ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc gacaacgcta tgggctgggt gcgacaggct      120

cctggcaagg gactggaatg ggtgtccgcc atctccggcc ctggctcctc tacctactac      180

gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc taaggtgctg      300

ggatggttcg actactgggg ccagggcacc ctcgtgaccg tgtcctctgc tagcaccaag      360

ggcccctccg tgtttcctct ggccccttcc agcaagtcca cctctggcgg aacagccgct      420

ctgggctgcc tggtggaaga ttacttcccc gagcccgtga cagtgtcttg gaactctggc      480

gccctgacct ccggcgtgca cacctttcca gctgtgctgc agtcctccgg cctgtactcc      540

ctgtcctccg tcgtgactgt gccctccagc tctctgggca cccagaccta catctgcaac      600

gtgaaccaca agccctccaa caccaaggtg gacgagaagg tggaacccaa gtcctgcgac      660

aagacccaca cctgtccccc ttgtcctgcc cctgaagctg ctggcggccc tagcgtgttc      720

ctgttccccc caaagcctaa ggacaccctg atgatctccc ggacccccga agtgacctgc      780

gtggtggtgg atgtgtccca cgaggaccct gaagtgaagt tcaattggta cgtggacggc      840

gtggaagtgc acaacgccaa gaccaagcct agagaggaac agtacaactc cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcatcag gactggctga acggcaaaga gtacaagtgc      960

aaggtgtcca acaaggccct gggcgctccc atcgaaaaga ccatctccaa ggccaagggc     1020

cagccccggg aacctcaagt gtgcaccctg ccccctagca gggacgagct gaccaagaac     1080

caggtgtccc tgagctgcgc tgtgaagggc ttctacccct ccgatatcgc cgtggaatgg     1140

gagagcaacg gccagcccga gaacaactat aagaccaccc cccctgtgct ggactccgac     1200

ggctcattct tcctggtgtc caagctgaca gtggacaagt cccggtggca gcagggcaac     1260

gtgttctcct gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg     1320

tccctgtctc ccggcaaa                                                   1338


<210>  30
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC''' and LC'''' anti-BCMA coding DNA

<400>  30
gaaatcgtgc tgacccagtc ccccggcacc ctgtcactgt ctccaggcga gagagccacc       60

ctgtcctgca gagcctccca gtccgtgtcc gacgagtacc tgtcctggta tcagcagaag      120

cccggccagg cccccagact gctgatccac tctgcctcta ccagagccac cggcatccct      180

gacagattct ccggctctgg ctccggcacc gatttcaccc tggccatctc tcggctggaa      240

cccgaggact tcgccgtgta ctactgccag cagtacggct acccccccga cttcaccttt      300

ggccagggca ccaaggtgga aatcaagcgt acggtggccg ctccctccgt gttcatcttc      360

cctccatccg accggaagct gaagtctggc accgcctctg tcgtgtgcct gctgaacaac      420

ttctaccccc gcgaggccaa ggtgcagtgg aaggtggaca acgccctgca gtccggcaac      480

tcccaggaat ccgtgaccga gcaggactcc aaggacagca cctactccct gtcctccacc      540

ctgaccctgt ccaaggccga ctacgagaag cacaaggtgt acgcctgcga agtgacccac      600

cagggcctgt ctagccccgt gaccaagtct ttcaaccggg gcgagtgc                   648


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 CDRH1

<400>  31

Thr Tyr Ala Met Asn 
1               5   


<210>  32
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 CDRH2

<400>  32

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  33
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 CDRH3

<400>  33

His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  


<210>  34
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 CDRL1

<400>  34

Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 CDRL2

<400>  35

Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 CDRL3

<400>  36

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  37
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 
    50                  55                  60                  


Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile 
65                  70                  75                  80  


Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu 
                85                  90                  95      


Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu 
            100                 105                 110         


Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys 
        115                 120                 125             


Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe 
    130                 135                 140                 


Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys 
145                 150                 155                 160 


Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu 
                165                 170                 175     


Ile Glu Lys Ser Ile Ser Ala Arg 
            180                 


<210>  38
<211>  207
<212>  PRT
<213>  Homo Sapiens

<400>  38

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


