                         SEQUENCE LISTING

<110>  Sanofi/Regeneron
 
<120>  METHODS OF DIAGNOSIS AND TREATMENT OF RHEUMATOID ARTHRITIS

<130>  705212 SA9-264

<140>  US62/837793
<141>  2019-04-24

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Arg Asp Ser Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  2
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain complementarity determining region 1

<400>  3

Arg Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain complementarity determining region 2

<400>  4

Ile Ser Trp Asn Ser Gly Arg Ile 
1               5               


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain complementarity determining region 3

<400>  5

Ala Lys Gly Arg Asp Ser Phe Asp Ile 
1               5                   


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain complementarity determining region 1

<400>  6

Gln Gly Ile Ser Ser Trp 
1               5       


<210>  7
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain complementarity determining region 2

<400>  7

Gly Ala Ser 
1           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain complementarity determining region 3

<400>  8

Gln Gln Ala Asn Ser Phe Pro Tyr Thr 
1               5                   


<210>  9
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Arg Asp Ser Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  10
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  11
<211>  675
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRP transcript variant 2 cDNA sequence (GenBank reference: 
       NP_001315986.1)

<400>  11
atggagaagc tgttgtgttt cttggtcttg accagcctct ctcatgcttt tggccagaca       60

gacatgtcga ggaaggcttt tgtgtttccc aaagagtcgg atacttccta tgtatccctc      120

aaagcaccgt taacgaagcc tctcaaagcc ttcactgtgt gcctccactt ctacacggaa      180

ctgtcctcga cccgtgggta cagtattttc tcgtatgcca ccaagagaca agacaatgag      240

attctcatat tttggtctaa ggatatagga tacagtttta cagtgggtgg gtctgaaata      300

ttattcgagg ttcctgaagt cacagtagct ccagtacaca tttgtacaag ctgggagtcc      360

gcctcaggga tcgtggagtt ctgggtagat gggaagccca gggtgaggaa gagtctgaag      420

aagggataca ctgtgggggc agaagcaagc atcatcttgg ggcaggagca ggattccttc      480

ggtgggaact ttgaaggaag ccagtccctg gtgggagaca ttggaaatgt gaacatgtgg      540

gactttgtgc tgtcaccaga tgagattaac accatctatc ttggcgggcc cttcagtcct      600

aatgtcctga actggcgggc actgaagtat gaagtgcaag gcgaagtgtt caccaaaccc      660

cagctgtggc cctga                                                       675


<210>  12
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRP peptide sequence

<400>  12

Met Glu Lys Leu Leu Cys Phe Leu Val Leu Thr Ser Leu Ser His Ala 
1               5                   10                  15      


Phe Gly Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu 
            20                  25                  30          


Ser Asp Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu 
        35                  40                  45              


Lys Ala Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr 
    50                  55                  60                  


Arg Gly Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu 
65                  70                  75                  80  


Ile Leu Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly 
                85                  90                  95      


Gly Ser Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val 
            100                 105                 110         


His Ile Cys Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp 
        115                 120                 125             


Val Asp Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr 
    130                 135                 140                 


Val Gly Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe 
145                 150                 155                 160 


Gly Gly Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn 
                165                 170                 175     


Val Asn Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile 
            180                 185                 190         


Tyr Leu Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu 
        195                 200                 205             


Lys Tyr Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro 
    210                 215                 220                 


<210>  13
<211>  2020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRP genomic DNA sequence (GenBank reference: NG_013007.1)

<400>  13
gactggattc agagactcaa acaatgttat tgaggcatgg tctatctctc agctctactc       60

gtgagtcaag gatggtgtat tagttggttt tcacactgct gtaaagaact acctgagtat      120

gggtaattta taaacaaaag aaattttaaa tgaacttaca gttccacatg tttggggagg      180

actcatgaaa cttacaatca tggtggaagg tgaaggggaa gcaggcattt tcttcacaag      240

gcagcaggag agagacagtg tgagtggggg actgccaagc acttttattt aaatcatcag      300

acctagtgag aactcattat catgagcaca gcatgggcaa aactacctcc acgatccaat      360

cttctcccac catgtccctc cctcaactca tggggattac aatttgagat gacatttggg      420

tgggaacaca gaaccaaacc atatcattcc acctctggct cctccaaaat atcatgttct      480

tttcacattt caaaaccaat cataccttcc caacagtcac ccaaacttaa ctcatttcag      540

cattaactca aaagtccaag tctaaagttc catctgagaa aaggcaagtc acttctgcct      600

attagcctag taaaataaaa aacaagttag ttacttccaa gatacagtgg gggtataggc      660

attgggtaaa tggtcctgtt tgaaatggga gaaattggcc aaaacaaagg ggccacaggc      720

cccatgtaaa tccaaaatct ggcaggacac tcatgaaatc ttaaagctcc aaaataatct      780

cctttgattc tttgtctcac atccagggca tgctgatgca agcggtaggc ttccatggcc      840

ttgggtagct ccatacttgt ggctcttcag ggtacagccc ctgtggctgc tttcacaggc      900

tggcattgaa cacttgcaag cttttctaag cacaaggtgc aaactgtcag tggttctacc      960

attctgggat ctggaggaca gtggccctct tctcacagat ccactaggca gtgccccagt     1020

ggggactctg tgtggagact ccaaccccac atttccctgc tgcattgccc tagtagaggt     1080

tttctgtgag ggctccatgc ctgcagaaga cttctgcctg aacatccagg tgtttccata     1140

catcttctga aatctagaca gaaactccca aagctcaact cttgtcttct gtgcatctgc     1200

accctcaaca ctacttggaa gccaccaagg cttggggctt gtgccctctg aagcaatggc     1260

ctgagctata tacattgccc ccttttagcc atggctggag ccgcagcagc tggcacacag     1320

ggtgccatgt tcctgggctg cacagagcag cggggccctg ggcctggccc atgataccat     1380

tttttcctcc taggcttttg gacctctgat gggaggggct gccatgaaga tcttctgaaa     1440

tgacctgaag acattttcct cattgttttg gctatcaaca ttcatctcct cattacttat     1500

gcaaatttct gcagccagct tgaatttttc cccagaaaat gggtttttct tttctaccac     1560

atggtcaggc tgcacatttt ccaaactttt atgctccctt tcccttttaa acataagttc     1620

caatttcaga tcatctcttt gtgaacacat atgattgtat gttttcagaa aaagccaggt     1680

cacttcttga atgctttggt gcttagaaat ttcttaagca ccaaagcatt caagaaatca     1740

tgtctcttaa gttaaaagtt ccacagatct ctagggcatg ggcaaaatgc caccattgtc     1800

tttgctaaaa catagaaaga gtgaccttta ctcccgtttc caataagttc ctcatctcca     1860

tctaaggaca cctctgcatg aacttcattt tccatatcac tatcagcatt ttggtcaaaa     1920

ccattcaaca aaactcagga agttccaagc ttttccacat cttcctgtct tctcctgagc     1980

cctccaaact cttccagcct ctgcccctag ttggttccaa                           2020


<210>  14
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP-3 peptide sequence

<400>  14

Met Lys Ser Leu Pro Ile Leu Leu Leu Leu Cys Val Ala Val Cys Ser 
1               5                   10                  15      


Ala Tyr Pro Leu Asp Gly Ala Ala Arg Gly Glu Asp Thr Ser Met Asn 
            20                  25                  30          


Leu Val Gln Lys Tyr Leu Glu Asn Tyr Tyr Asp Leu Lys Lys Asp Val 
        35                  40                  45              


Lys Gln Phe Val Arg Arg Lys Asp Ser Gly Pro Val Val Lys Lys Ile 
    50                  55                  60                  


Arg Glu Met Gln Lys Phe Leu Gly Leu Glu Val Thr Gly Lys Leu Asp 
65                  70                  75                  80  


Ser Asp Thr Leu Glu Val Met Arg Lys Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val Gly His Phe Arg Thr Phe Pro Gly Ile Pro Lys Trp Arg Lys Thr 
            100                 105                 110         


His Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Lys Asp 
        115                 120                 125             


Ala Val Asp Ser Ala Val Glu Lys Ala Leu Lys Val Trp Glu Glu Val 
    130                 135                 140                 


Thr Pro Leu Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met 
145                 150                 155                 160 


Ile Ser Phe Ala Val Arg Glu His Gly Asp Phe Tyr Pro Phe Asp Gly 
                165                 170                 175     


Pro Gly Asn Val Leu Ala His Ala Tyr Ala Pro Gly Pro Gly Ile Asn 
            180                 185                 190         


Gly Asp Ala His Phe Asp Asp Asp Glu Gln Trp Thr Lys Asp Thr Thr 
        195                 200                 205             


Gly Thr Asn Leu Phe Leu Val Ala Ala His Glu Ile Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Phe His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr 
225                 230                 235                 240 


His Ser Leu Thr Asp Leu Thr Arg Phe Arg Leu Ser Gln Asp Asp Ile 
                245                 250                 255     


Asn Gly Ile Gln Ser Leu Tyr Gly Pro Pro Pro Asp Ser Pro Glu Thr 
            260                 265                 270         


Pro Leu Val Pro Thr Glu Pro Val Pro Pro Glu Pro Gly Thr Pro Ala 
        275                 280                 285             


Asn Cys Asp Pro Ala Leu Ser Phe Asp Ala Val Ser Thr Leu Arg Gly 
    290                 295                 300                 


Glu Ile Leu Ile Phe Lys Asp Arg His Phe Trp Arg Lys Ser Leu Arg 
305                 310                 315                 320 


Lys Leu Glu Pro Glu Leu His Leu Ile Ser Ser Phe Trp Pro Ser Leu 
                325                 330                 335     


Pro Ser Gly Val Asp Ala Ala Tyr Glu Val Thr Ser Lys Asp Leu Val 
            340                 345                 350         


Phe Ile Phe Lys Gly Asn Gln Phe Trp Ala Ile Arg Gly Asn Glu Val 
        355                 360                 365             


Arg Ala Gly Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr 
    370                 375                 380                 


Val Arg Lys Ile Asp Ala Ala Ile Ser Asp Lys Glu Lys Asn Lys Thr 
385                 390                 395                 400 


Tyr Phe Phe Val Glu Asp Lys Tyr Trp Arg Phe Asp Glu Lys Arg Asn 
                405                 410                 415     


Ser Met Glu Pro Gly Phe Pro Lys Gln Ile Ala Glu Asp Phe Pro Gly 
            420                 425                 430         


Ile Asp Ser Lys Ile Asp Ala Val Phe Glu Glu Phe Gly Phe Phe Tyr 
        435                 440                 445             


Phe Phe Thr Gly Ser Ser Gln Leu Glu Phe Asp Pro Asn Ala Lys Lys 
    450                 455                 460                 


Val Thr His Thr Leu Lys Ser Asn Ser Trp Leu Asn Cys 
465                 470                 475         


<210>  15
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MMP-3 cDNA sequence

<400>  15
atgaagagtc ttccaatcct actgttgctg tgcgtggcag tttgctcagc ctatccattg       60

gatggagctg caaggggtga ggacaccagc atgaaccttg ttcagaaata tctagaaaac      120

tactacgacc tcaaaaaaga tgtgaaacag tttgttagga gaaaggacag tggtcctgtt      180

gttaaaaaaa tccgagaaat gcagaagttc cttggattgg aggtgacggg gaagctggac      240

tccgacactc tggaggtgat gcgcaagccc aggtgtggag ttcctgatgt tggtcacttc      300

agaacctttc ctggcatccc gaagtggagg aaaacccacc ttacatacag gattgtgaat      360

tatacaccag atttgccaaa agatgctgtt gattctgctg ttgagaaagc tctgaaagtc      420

tgggaagagg tgactccact cacattctcc aggctgtatg aaggagaggc tgatataatg      480

atctcttttg cagttagaga acatggagac ttttaccctt ttgatggacc tggaaatgtt      540

ttggcccatg cctatgcccc tgggccaggg attaatggag atgcccactt tgatgatgat      600

gaacaatgga caaaggatac aacagggacc aatttatttc tcgttgctgc tcatgaaatt      660

ggccactccc tgggtctctt tcactcagcc aacactgaag ctttgatgta cccactctat      720

cactcactca cagacctgac tcggttccgc ctgtctcaag atgatataaa tggcattcag      780

tccctctatg gacctccccc tgactcccct gagacccccc tggtacccac ggaacctgtc      840

cctccagaac ctgggacgcc agccaactgt gatcctgctt tgtcctttga tgctgtcagc      900

actctgaggg gagaaatcct gatctttaaa gacaggcact tttggcgcaa atccctcagg      960

aagcttgaac ctgaattgca tttgatctct tcattttggc catctcttcc ttcaggcgtg     1020

gatgccgcat atgaagttac tagcaaggac ctcgttttca tttttaaagg aaatcaattc     1080

tgggctatca gaggaaatga ggtacgagct ggatacccaa gaggcatcca caccctaggt     1140

ttccctccaa ccgtgaggaa aatcgatgca gccatttctg ataaggaaaa gaacaaaaca     1200

tatttctttg tagaggacaa atactggaga tttgatgaga agagaaattc catggagcca     1260

ggctttccca agcaaatagc tgaagacttt ccagggattg actcaaagat tgatgctgtt     1320

tttgaagaat ttgggttctt ttatttcttt actggatctt cacagttgga gtttgaccca     1380

aatgcaaaga aagtgacaca cactttgaag agtaacagct ggcttaattg ttga           1434


<210>  16
<211>  1822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MMP-3 mRNA sequence (GenBank reference: NM_002422.5)

<400>  16
acaaggaggc aggcaagaca gcaaggcata gagacaacat agagctaagt aaagccagtg       60

gaaatgaaga gtcttccaat cctactgttg ctgtgcgtgg cagtttgctc agcctatcca      120

ttggatggag ctgcaagggg tgaggacacc agcatgaacc ttgttcagaa atatctagaa      180

aactactacg acctcaaaaa agatgtgaaa cagtttgtta ggagaaagga cagtggtcct      240

gttgttaaaa aaatccgaga aatgcagaag ttccttggat tggaggtgac ggggaagctg      300

gactccgaca ctctggaggt gatgcgcaag cccaggtgtg gagttcctga tgttggtcac      360

ttcagaacct ttcctggcat cccgaagtgg aggaaaaccc accttacata caggattgtg      420

aattatacac cagatttgcc aaaagatgct gttgattctg ctgttgagaa agctctgaaa      480

gtctgggaag aggtgactcc actcacattc tccaggctgt atgaaggaga ggctgatata      540

atgatctctt ttgcagttag agaacatgga gacttttacc cttttgatgg acctggaaat      600

gttttggccc atgcctatgc ccctgggcca gggattaatg gagatgccca ctttgatgat      660

gatgaacaat ggacaaagga tacaacaggg accaatttat ttctcgttgc tgctcatgaa      720

attggccact ccctgggtct ctttcactca gccaacactg aagctttgat gtacccactc      780

tatcactcac tcacagacct gactcggttc cgcctgtctc aagatgatat aaatggcatt      840

cagtccctct atggacctcc ccctgactcc cctgagaccc ccctggtacc cacggaacct      900

gtccctccag aacctgggac gccagccaac tgtgatcctg ctttgtcctt tgatgctgtc      960

agcactctga ggggagaaat cctgatcttt aaagacaggc acttttggcg caaatccctc     1020

aggaagcttg aacctgaatt gcatttgatc tcttcatttt ggccatctct tccttcaggc     1080

gtggatgccg catatgaagt tactagcaag gacctcgttt tcatttttaa aggaaatcaa     1140

ttctgggcta tcagaggaaa tgaggtacga gctggatacc caagaggcat ccacacccta     1200

ggtttccctc caaccgtgag gaaaatcgat gcagccattt ctgataagga aaagaacaaa     1260

acatatttct ttgtagagga caaatactgg agatttgatg agaagagaaa ttccatggag     1320

ccaggctttc ccaagcaaat agctgaagac tttccaggga ttgactcaaa gattgatgct     1380

gtttttgaag aatttgggtt cttttatttc tttactggat cttcacagtt ggagtttgac     1440

ccaaatgcaa agaaagtgac acacactttg aagagtaaca gctggcttaa ttgttgaaag     1500

agatatgtag aaggcacaat atgggcactt taaatgaagc taataattct tcacctaagt     1560

ctctgtgaat tgaaatgttc gttttctcct gcctgtgctg tgactcgagt cacactcaag     1620

ggaacttgag cgtgaatctg tatcttgccg gtcattttta tgttattaca gggcattcaa     1680

atgggctgct gcttagcttg caccttgtca catagagtga tctttcccaa gagaagggga     1740

agcactcgtg tgcaacagac aagtgactgt atctgtgtag actatttgct tatttaataa     1800

agacgatttg tcagttattt ta                                              1822


<210>  17
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL13 peptide sequence (GenBank reference: NP_006410.1)

<400>  17

Met Lys Phe Ile Ser Thr Ser Leu Leu Leu Met Leu Leu Val Ser Ser 
1               5                   10                  15      


Leu Ser Pro Val Gln Gly Val Leu Glu Val Tyr Tyr Thr Ser Leu Arg 
            20                  25                  30          


Cys Arg Cys Val Gln Glu Ser Ser Val Phe Ile Pro Arg Arg Phe Ile 
        35                  40                  45              


Asp Arg Ile Gln Ile Leu Pro Arg Gly Asn Gly Cys Pro Arg Lys Glu 
    50                  55                  60                  


Ile Ile Val Trp Lys Lys Asn Lys Ser Ile Val Cys Val Asp Pro Gln 
65                  70                  75                  80  


Ala Glu Trp Ile Gln Arg Met Met Glu Val Leu Arg Lys Arg Ser Ser 
                85                  90                  95      


Ser Thr Leu Pro Val Pro Val Phe Lys Arg Lys Ile Pro 
            100                 105                 


<210>  18
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CXCL13 cDNA sequence (GenBank reference: NP_006410.1)

<400>  18
atgaagttca tctcgacatc tctgcttctc atgctgctgg tcagcagcct ctctccagtc       60

caaggtgttc tggaggtcta ttacacaagc ttgaggtgta gatgtgtcca agagagctca      120

gtctttatcc ctagacgctt cattgatcga attcaaatct tgccccgtgg gaatggttgt      180

ccaagaaaag aaatcatagt ctggaagaag aacaagtcaa ttgtgtgtgt ggaccctcaa      240

gctgaatgga tacaaagaat gatggaagta ttgagaaaaa gaagttcttc aactctacca      300

gttccagtgt ttaagagaaa gattccctga                                       330


<210>  19
<211>  1219
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CXCL13 genomic DNA sequence (GenBank reference: NM_006419.2)

<400>  19
gagaagatgt ttgaaaaaac tgactctgct aatgagcctg gactcagagc tcaagtctga       60

actctacctc cagacagaat gaagttcatc tcgacatctc tgcttctcat gctgctggtc      120

agcagcctct ctccagtcca aggtgttctg gaggtctatt acacaagctt gaggtgtaga      180

tgtgtccaag agagctcagt ctttatccct agacgcttca ttgatcgaat tcaaatcttg      240

ccccgtggga atggttgtcc aagaaaagaa atcatagtct ggaagaagaa caagtcaatt      300

gtgtgtgtgg accctcaagc tgaatggata caaagaatga tggaagtatt gagaaaaaga      360

agttcttcaa ctctaccagt tccagtgttt aagagaaaga ttccctgatg ctgatatttc      420

cactaagaac acctgcattc ttcccttatc cctgctctgg attttagttt tgtgcttagt      480

taaatctttt ccaggaaaaa gaacttcccc atacaaataa gcatgagact atgtaaaaat      540

aaccttgcag aagctgatgg ggcaaactca agcttcttca ctcacagcac cctatataca      600

cttggagttt gcattcttat tcatcaggga ggaaagtttc tttgaaaata gttattcagt      660

tataagtaat acaggattat tttgattata tacttgttgt ttaatgttta aaatttctta      720

gaaaacaatg gaatgagaat ttaagcctca aatttgaaca tgtggcttga attaagaaga      780

aaattatggc atatattaaa agcaggcttc tatgaaagac tcaaaaagct gcctgggagg      840

cagatggaac ttgagcctgt caagaggcaa aggaatccat gtagtagata tcctctgctt      900

aaaaactcac tacggaggag aattaagtcc tacttttaaa gaatttcttt ataaaattta      960

ctgtctaaga ttaatagcat tcgaagatcc ccagacttca tagaatactc agggaaagca     1020

tttaaagggt gatgtacaca tgtatccttt cacacatttg ccttgacaaa cttctttcac     1080

tcacatcttt ttcactgact ttttttgtgg ggggcggggc cggggggact ctggtatcta     1140

attctttaat gattcctata aatctaatga cattcaataa agttgagcaa acattttact     1200

taaaaaaaaa aaaaaaaaa                                                  1219


<210>  20
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Serum amyloid A peptide sequence (GenBank reference: AAB24060.1)

<400>  20

Met Arg Leu Phe Thr Gly Ile Val Phe Cys Ser Leu Val Met Gly Val 
1               5                   10                  15      


Thr Ser Glu Ser Trp Arg Ser Phe Phe Lys Glu Ala Leu Gln Gly Val 
            20                  25                  30          


Gly Asp Met Gly Arg Ala Tyr Trp Asp Ile Met Ile Ser Asn His Gln 
        35                  40                  45              


Asn Ser Asn Arg Tyr Leu Tyr Ala Arg Gly Asn Tyr Asp Ala Ala Gln 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Lys Leu Ile Ser Arg Ser Arg 
65                  70                  75                  80  


Val Tyr Leu Gln Gly Leu Ile Asp Tyr Tyr Leu Phe Gly Asn Ser Ser 
                85                  90                  95      


Thr Val Leu Glu Asp Ser Lys Ser Asn Glu Lys Ala Glu Glu Trp Gly 
            100                 105                 110         


Arg Ser Gly Lys Asp Pro Asp Arg Phe Arg Pro Asp Gly Leu Pro Lys 
        115                 120                 125             


Lys Tyr 
    130 


<210>  21
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Serum amyloid A cDNA sequence (GenBank reference: AAB24060.1)

<400>  21
atgaggcttt tcacaggcat tgttttctgc tccttggtca tgggagtcac cagtgaaagc       60

tggcgttcgt ttttcaagga ggctctccaa ggggttgggg acatgggcag agcctattgg      120

gacataatga tatccaatca ccaaaattca aacagatatc tctatgctcg gggaaactat      180

gatgctgccc aaagaggacc tgggggtgtc tgggctgcta aactcatcag ccgttccagg      240

gtctatcttc agggattaat agactactat ttatttggaa acagcagcac tgtattggag      300

gactcgaagt ccaacgagaa agctgaggaa tggggccgga gtggcaaaga ccccgaccgc      360

ttcagacctg acggcctgcc taagaaatac tga                                   393


<210>  22
<211>  614
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Serum amyloid A mRNA sequence (GenBank reference: M81349.1)

<400>  22
tatagctcca cggccagaag ataccagcag ctctgccttt actgaaattt cagctggaga       60

aaggtccaca gcacaatgag gcttttcaca ggcattgttt tctgctcctt ggtcatggga      120

gtcaccagtg aaagctggcg ttcgtttttc aaggaggctc tccaaggggt tggggacatg      180

ggcagagcct attgggacat aatgatatcc aatcaccaaa attcaaacag atatctctat      240

gctcggggaa actatgatgc tgcccaaaga ggacctgggg gtgtctgggc tgctaaactc      300

atcagccgtt ccagggtcta tcttcaggga ttaatagact actatttatt tggaaacagc      360

agcactgtat tggaggactc gaagtccaac gagaaagctg aggaatgggg ccggagtggc      420

aaagaccccg accgcttcag acctgacggc ctgcctaaga aatactgagc ttcctgctcc      480

tctgctctca gggaaactgg gctgtgagcc acacacttct ccccccagac agggacacag      540

ggtcactgag ctttgtgtcc ccaggaactg gtatagggca cctagaggtg ttcaataaat      600

gtttgtcaaa ttga                                                        614


<210>  23
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sICAM-1 peptide sequence (GenBank reference: NP_000192.2)

<400>  23

Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
1               5                   10                  15      


Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 
            20                  25                  30          


Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 
        35                  40                  45              


Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 
    50                  55                  60                  


Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 
65                  70                  75                  80  


Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 
                85                  90                  95      


Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 
            100                 105                 110         


Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly 
        115                 120                 125             


Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala 
    130                 135                 140                 


Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu 
145                 150                 155                 160 


Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg 
                165                 170                 175     


Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu 
            180                 185                 190         


Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln 
        195                 200                 205             


Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro 
    210                 215                 220                 


Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp 
225                 230                 235                 240 


Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp 
                245                 250                 255     


Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala 
            260                 265                 270         


Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu 
        275                 280                 285             


Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr 
    290                 295                 300                 


Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro 
305                 310                 315                 320 


Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro 
                325                 330                 335     


Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro 
            340                 345                 350         


Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser 
        355                 360                 365             


Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys 
    370                 375                 380                 


Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu 
385                 390                 395                 400 


Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr 
                405                 410                 415     


Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu 
            420                 425                 430         


Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr 
        435                 440                 445             


Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly 
    450                 455                 460                 


Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu 
465                 470                 475                 480 


Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala 
                485                 490                 495     


Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr 
            500                 505                 510         


Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln 
        515                 520                 525             


Ala Thr Pro Pro 
    530         


<210>  24
<211>  1598
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sICAM-1 cDNA sequence (GenBank reference: NP_000192.2)

<400>  24
atggctccca gcagcccccg gcccgcgctg cccgcactcc tggtcctgct cggggctctg       60

ttcccaggac ctggcaatgc ccagacatct gtgtccccct caaaagtcat cctgccccgg      120

ggaggctccg tgctggtgac tgcagcacct cctgtgacca gcccaagttg ttgggcatag      180

agaccccgtt gcctaaaaag gagttgctcc tgcctgggaa caaccggaag gtgtatgaac      240

tgagcaatgt gcaagaagat agccaaccaa tgtgctattc aaactgccct gatgggcagt      300

caacagctaa aaccttcctc accgtgtact ggactccaga acgggtggaa ctggcacccc      360

tcccctcttg gcagccagtg ggcaagaacc ttaccctacg ctgccaggtg gagggtgggg      420

caccccgggc caacctcacc gtggtgctgc tccgtgggga gaaggagctg aaacgggagc      480

cagctgtggg ggagcccgct gaggtcacga ccacggtgct ggtgaggaga gatcaccatg      540

gagccaattt ctcgtgccgc actgaactgg acctgcggcc ccaagggctg gagctgtttg      600

agaacacctc ggccccctac cagctccaga cctttgtcct gccagcgact cccccacaac      660

ttgtcagccc ccgggtccta gaggtggaca cgcaggggac cgtggtctgt tccctggacg      720

ggctgttccc agtctcggag gcccaggtcc acctggcact gggggaccag aggttgaacc      780

ccacagtcac ctatggcaac gactccttct cggccaaggc ctcagtcagt gtgaccgcag      840

aggacgaggg cacccagcgg ctgacgtgtg cagtaatact ggggaaccag agccaggaga      900

cactgcagac agtgaccatc tacagctttc cggcgcccaa cgtgattctg acgaagccag      960

aggtctcaga agggaccgag gtgacagtga agtgtgaggc ccaccctaga gccaaggtga     1020

cgctgaatgg ggttccagcc cagccactgg gcccgagggc ccagctcctg ctgaaggcca     1080

ccccagagga caacgggcgc agcttctcct gctctgcaac cctggaggtg gccggccagc     1140

ttatacacaa gaaccagacc cgggagcttc gtgtcctgta tggcccccga ctggacgaga     1200

gggattgtcc gggaaactgg acgtggccag aaaattccca gcagactcca atgtgccagg     1260

cttgggggaa cccattgccc gagctcaagt gtctaaagga tggcactttc ccactgccca     1320

tcggggaatc agtgactgtc actcgagatc ttgagggcac ctacctctgt cgggccagga     1380

gcactcaagg ggaggtcacc cgcaaggtga ccgtgaatgt gctctccccc cggtatgaga     1440

ttgtcatcat cactgtggta gcagccgcag tcataatggg cactgcaggc ctcagcacgt     1500

acctctataa ccgccagcgg aagatcaaga aatacagact acaacaggcc caaaaaggga     1560

cccccatgaa accgaacaca caagccacgc ctccctga                             1598


<210>  25
<211>  2967
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sICAM-1 mRNA sequence (GenBank reference: NM_000201.3)

<400>  25
gagctcctct gctactcaga gttgcaacct cagcctcgct atggctccca gcagcccccg       60

gcccgcgctg cccgcactcc tggtcctgct cggggctctg ttcccaggac ctggcaatgc      120

ccagacatct gtgtccccct caaaagtcat cctgccccgg ggaggctccg tgctggtgac      180

atgcagcacc tcctgtgacc agcccaagtt gttgggcata gagaccccgt tgcctaaaaa      240

ggagttgctc ctgcctggga acaaccggaa ggtgtatgaa ctgagcaatg tgcaagaaga      300

tagccaacca atgtgctatt caaactgccc tgatgggcag tcaacagcta aaaccttcct      360

caccgtgtac tggactccag aacgggtgga actggcaccc ctcccctctt ggcagccagt      420

gggcaagaac cttaccctac gctgccaggt ggagggtggg gcaccccggg ccaacctcac      480

cgtggtgctg ctccgtgggg agaaggagct gaaacgggag ccagctgtgg gggagcccgc      540

tgaggtcacg accacggtgc tggtgaggag agatcaccat ggagccaatt tctcgtgccg      600

cactgaactg gacctgcggc cccaagggct ggagctgttt gagaacacct cggcccccta      660

ccagctccag acctttgtcc tgccagcgac tcccccacaa cttgtcagcc cccgggtcct      720

agaggtggac acgcagggga ccgtggtctg ttccctggac gggctgttcc cagtctcgga      780

ggcccaggtc cacctggcac tgggggacca gaggttgaac cccacagtca cctatggcaa      840

cgactccttc tcggccaagg cctcagtcag tgtgaccgca gaggacgagg gcacccagcg      900

gctgacgtgt gcagtaatac tggggaacca gagccaggag acactgcaga cagtgaccat      960

ctacagcttt ccggcgccca acgtgattct gacgaagcca gaggtctcag aagggaccga     1020

ggtgacagtg aagtgtgagg cccaccctag agccaaggtg acgctgaatg gggttccagc     1080

ccagccactg ggcccgaggg cccagctcct gctgaaggcc accccagagg acaacgggcg     1140

cagcttctcc tgctctgcaa ccctggaggt ggccggccag cttatacaca agaaccagac     1200

ccgggagctt cgtgtcctgt atggcccccg actggacgag agggattgtc cgggaaactg     1260

gacgtggcca gaaaattccc agcagactcc aatgtgccag gcttggggga acccattgcc     1320

cgagctcaag tgtctaaagg atggcacttt cccactgccc atcggggaat cagtgactgt     1380

cactcgagat cttgagggca cctacctctg tcgggccagg agcactcaag gggaggtcac     1440

ccgcaaggtg accgtgaatg tgctctcccc ccggtatgag attgtcatca tcactgtggt     1500

agcagccgca gtcataatgg gcactgcagg cctcagcacg tacctctata accgccagcg     1560

gaagatcaag aaatacagac tacaacaggc ccaaaaaggg acccccatga aaccgaacac     1620

acaagccacg cctccctgaa cctatcccgg gacagggcct cttcctcggc cttcccatat     1680

tggtggcagt ggtgccacac tgaacagagt ggaagacata tgccatgcag ctacacctac     1740

cggccctggg acgccggagg acagggcatt gtcctcagtc agatacaaca gcatttgggg     1800

ccatggtacc tgcacaccta aaacactagg ccacgcatct gatctgtagt cacatgacta     1860

agccaagagg aaggagcaag actcaagaca tgattgatgg atgttaaagt ctagcctgat     1920

gagaggggaa gtggtggggg agacatagcc ccaccatgag gacatacaac tgggaaatac     1980

tgaaacttgc tgcctattgg gtatgctgag gccccacaga cttacagaag aagtggccct     2040

ccatagacat gtgtagcatc aaaacacaaa ggcccacact tcctgacgga tgccagcttg     2100

ggcactgctg tctactgacc ccaacccttg atgatatgta tttattcatt tgttatttta     2160

ccagctattt attgagtgtc ttttatgtag gctaaatgaa cataggtctc tggcctcacg     2220

gagctcccag tcctaatcac attcaaggtc accaggtaca gttgtacagg ttgtacactg     2280

caggagagtg cctggcaaaa agatcaaatg gggctgggac ttctcattgg ccaacctgcc     2340

tttccccaga aggagtgatt tttctatcgg cacaaaagca ctatatggac tggtaatggt     2400

tacaggttca gagattaccc agtgaggcct tattcctccc ttccccccaa aactgacacc     2460

tttgttagcc acctccccac ccacatacat ttctgccagt gttcacaatg acactcagcg     2520

gtcatgtctg gacatgagtg cccagggaat atgcccaagc tatgccttgt cctcttgtcc     2580

tgtttgcatt tcactgggag cttgcactat gcagctccag tttcctgcag tgatcagggt     2640

cctgcaagca gtggggaagg gggccaaggt attggaggac tccctcccag ctttggaagc     2700

ctcatccgcg tgtgtgtgtg tgtgtatgtg tagacaagct ctcgctctgt cacccaggct     2760

ggagtgcagt ggtgcaatca tggttcactg cagtcttgac cttttgggct caagtgatcc     2820

tcccacctca gcctcctgag tagctgggac cataggctca caacaccaca cctggcaaat     2880

ttgatttttt ttttttttcc agagacgggg tctcgcaaca ttgcccagac ttcctttgtg     2940

ttagttaata aagctttctc aactgcc                                         2967


