                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Song, Wenchao
       Miwa, Takashi
       Gullipalli, Damodar
       Sato, Sayaka
       Tsui, Ping
       Zhu, Yingjie
       Zhu, Xihua
 
<120>  BI-FUNCTIONAL HUMANIZED ANTI-C5 ANTIBODIES AND FACTOR H FUSION 
       PROTEINS AND USES THEREOF

<130>  046483-6180-00WO

<150>  US 62/837,853
<151>  2019-04-24

<160>  84    

<170>  PatentIn version 3.5

<210>  1
<211>  482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VH-11801

<400>  1
cagcatatga tcagtgtcct ctccaaagtc cttgaacata gactctaacc atggactgga       60

cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag gttcagctgg      120

tgcagtctgg agctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggctt      180

ctggatacac aatcacagac tacaatttgg actgggtgcg acaggcccct ggacaagggc      240

ttgagtggat gggagatatt agtcctaact atggttatac tatctacaac cagaaattca      300

aggacagagt caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga      360

gcctgagatc tgacgacacg gccgtgtatt actgtgcgag aagggacatt cgttactccg      420

gtaattccta caaatggtac ttcgatgtct ggggccaagg gacaatggtc accgtctctt      480

ca                                                                     482


<210>  2
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VH-11801 (amino acid)

<400>  2

Met Asp Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile 
        35                  40                  45              


Thr Asp Tyr Asn Leu Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Ser Pro Asn Tyr Gly Tyr Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys 
        115                 120                 125             


Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 Humanized 2G1 VH-11801 (amino acid)

<400>  3

Gly Tyr Thr Ile Thr Asp Tyr Asn Leu Asp 
1               5                   10  


<210>  4
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 Humanized 2G1 VH-11801 (amino acid)

<400>  4

Asp Ile Ser Pro Asn Tyr Gly Tyr Thr Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 Humanized 2G1 VH-11801 (amino acid)

<400>  5

Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys Trp Tyr Phe Asp Val 
1               5                   10                  15      


<210>  6
<211>  428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VL-1901

<400>  6
gtcagagccc tggggaggaa ctgctcagtt aggacccaga gggaaccatg gaagccccag       60

ctcagcttct cttcctcctg ctactctggc tcccagatac caccggagac atccagttga      120

cccagtctcc atccttcctg tctgcatctg taggagacag agtcaccatc acttgcagga      180

caagtaagag cataagcaaa tatttagcct ggtatcagca aaaaccaggg aaagccccta      240

agctcctgat ctattctgga tccaccttgc aatctggggt cccatcaagg ttcagcggca      300

gtggatctgg gacagaattc actctcacaa tcagcagcct gcagcctgaa gattttgcaa      360

cttattactg tcaacaacat aatgaatacc cgtacacgtt tggccagggg accaagctgg      420

agatcaaa                                                               428


<210>  7
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VL-1901 (amino acid)

<400>  7

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Lys Ser 
        35                  40                  45              


Ile Ser Lys Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asn 
            100                 105                 110         


Glu Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 Humanized 2G1 VL-1901 (amino acid)

<400>  8

Arg Thr Ser Lys Ser Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 Humanized 2G1 VL-1901 (amino acid)

<400>  9

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 Humanized 2G1 VL-1901 (amino acid)

<400>  10

Gln Gln His Asn Glu Tyr Pro Tyr Thr 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 Humanized 2G1 VL-1901 variant (Q->H mutation in CDR3) (amino
       acid)

<400>  11

His Gln His Asn Glu Tyr Pro Tyr Thr 
1               5                   


<210>  12
<211>  428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VL-1901 variant (Q->H mutation in CDR3)

<400>  12
gtcagagccc tggggaggaa ctgctcagtt aggacccaga gggaaccatg gaagccccag       60

ctcagcttct cttcctcctg ctactctggc tcccagatac caccggagac atccagttga      120

cccagtctcc atccttcctg tctgcatctg taggagacag agtcaccatc acttgcagga      180

caagtaagag cataagcaaa tatttagcct ggtatcagca aaaaccaggg aaagccccta      240

agctcctgat ctattctgga tccaccttgc aatctggggt cccatcaagg ttcagcggca      300

gtggatctgg gacagaattc actctcacaa tcagcagcct gcagcctgaa gattttgcaa      360

cttattactg tcatcaacat aatgaatacc cgtacacgtt tggccagggg accaagctgg      420

agatcaaa                                                               428


<210>  13
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VL-1901 variant (Q->H mutation in CDR3) (amino 
       acid)

<400>  13

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Lys Ser 
        35                  40                  45              


Ile Ser Lys Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln His Asn 
            100                 105                 110         


Glu Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 Humanized 2G1 VL-1901 variant (T->H mutation in CDR1) (amino
       acid)

<400>  14

Arg His Ser Lys Ser Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  15
<211>  428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VL-1901 variant (T->H mutation in CDR1)

<400>  15
gtcagagccc tggggaggaa ctgctcagtt aggacccaga gggaaccatg gaagccccag       60

ctcagcttct cttcctcctg ctactctggc tcccagatac caccggagac atccagttga      120

cccagtctcc atccttcctg tctgcatctg taggagacag agtcaccatc acttgcaggc      180

atagtaagag cataagcaaa tatttagcct ggtatcagca aaaaccaggg aaagccccta      240

agctcctgat ctattctgga tccaccttgc aatctggggt cccatcaagg ttcagcggca      300

gtggatctgg gacagaattc actctcacaa tcagcagcct gcagcctgaa gattttgcaa      360

cttattactg tcaacaacat aatgaatacc cgtacacgtt tggccagggg accaagctgg      420

agatcaaa                                                               428


<210>  16
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VL-1901 variant (T->H mutation in CDR1) (amino 
       acid)

<400>  16

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg His Ser Lys Ser 
        35                  40                  45              


Ile Ser Lys Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asn 
            100                 105                 110         


Glu Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 Humanized 2G1 VH-11801 variant (I->H mutation in CDR1) 
       (amino acid)

<400>  17

Arg His Ser Lys Ser Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  18
<211>  482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VH-11801 variant (I->H mutation in CDR1)

<400>  18
cagcatatga tcagtgtcct ctccaaagtc cttgaacata gactctaacc atggactgga       60

cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag gttcagctgg      120

tgcagtctgg agctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggctt      180

ctggatacac acatacagac tacaatttgg actgggtgcg acaggcccct ggacaagggc      240

ttgagtggat gggagatatt agtcctaact atggttatac tatctacaac cagaaattca      300

aggacagagt caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga      360

gcctgagatc tgacgacacg gccgtgtatt actgtgcgag aagggacatt cgttactccg      420

gtaattccta caaatggtac ttcgatgtct ggggccaagg gacaatggtc accgtctctt      480

ca                                                                     482


<210>  19
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VH-11801 variant (I->H mutation in CDR1) (amino 
       acid)

<400>  19

Met Asp Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr His 
        35                  40                  45              


Thr Asp Tyr Asn Leu Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Ser Pro Asn Tyr Gly Tyr Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys 
        115                 120                 125             


Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 Humanized 2G1 VH-11801 variant (N->H mutation in CDR1) 
       (amino acid)

<400>  20

Gly Tyr Thr Ile Thr Asp Tyr His Leu Asp 
1               5                   10  


<210>  21
<211>  481
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VH-11801 variant (N->H mutation in CDR1)

<400>  21
cagcatatga tcagtgtcct ctccaaagtc cttgaacata gactctaacc atggactgga       60

cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag gttcagctgg      120

tgcagtctgg agctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggctt      180

ctggatacac aatcacagac taccatttgg actgggtgcg acaggcccct ggacaagggc      240

ttgagtggat gggagatatt agtcctaact atggttatac tatctacaac cagaaattca      300

aggacagagt caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga      360

gcctgagatc tgacgacacg gccgtgtatt actgtgcgag aagggacatt cgttactccg      420

gtaattccta caaatggtac ttcgatgtct ggggccaagg gacaatggtc accgtctctt      480

c                                                                      481


<210>  22
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VH-11801 variant (N->H mutation in CDR1) (amino 
       acid)

<400>  22

Met Asp Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile 
        35                  40                  45              


Thr Asp Tyr His Leu Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Ser Pro Asn Tyr Gly Tyr Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys 
        115                 120                 125             


Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 Humanized 2G1 VL-1901 variant (Y->H mutation in CDR1) (amino
       acid)

<400>  23

Arg Thr Ser Lys Ser Ile Ser Lys His Leu Ala 
1               5                   10      


<210>  24
<211>  428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VL-1901 variant (Y->H mutation in CDR1)

<400>  24
gtcagagccc tggggaggaa ctgctcagtt aggacccaga gggaaccatg gaagccccag       60

ctcagcttct cttcctcctg ctactctggc tcccagatac caccggagac atccagttga      120

cccagtctcc atccttcctg tctgcatctg taggagacag agtcaccatc acttgcagga      180

caagtaagag cataagcaaa catttagcct ggtatcagca aaaaccaggg aaagccccta      240

agctcctgat ctattctgga tccaccttgc aatctggggt cccatcaagg ttcagcggca      300

gtggatctgg gacagaattc actctcacaa tcagcagcct gcagcctgaa gattttgcaa      360

cttattactg tcaacaacat aatgaatacc cgtacacgtt tggccagggg accaagctgg      420

agatcaaa                                                               428


<210>  25
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VL-1901 variant (Y->H mutation in CDR1) (amino 
       acid)

<400>  25

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Lys Ser 
        35                  40                  45              


Ile Ser Lys His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asn 
            100                 105                 110         


Glu Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 Humanized 2G1 VH-11801 variant (Y->H mutation in CDR2)

<400>  26

Asp Ile Ser Pro Asn His Gly Tyr Thr Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  27
<211>  482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VH-11801 variant (Y->H mutation in CDR2)

<400>  27
cagcatatga tcagtgtcct ctccaaagtc cttgaacata gactctaacc atggactgga       60

cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag gttcagctgg      120

tgcagtctgg agctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggctt      180

ctggatacac aatcacagac tacaatttgg actgggtgcg acaggcccct ggacaagggc      240

ttgagtggat gggagatatt agtcctaacc atggttatac tatctacaac cagaaattca      300

aggacagagt caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga      360

gcctgagatc tgacgacacg gccgtgtatt actgtgcgag aagggacatt cgttactccg      420

gtaattccta caaatggtac ttcgatgtct ggggccaagg gacaatggtc accgtctctt      480

ca                                                                     482


<210>  28
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VH-11801 variant (Y->H mutation in CDR2) (amino 
       acid)

<400>  28

Met Asp Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile 
        35                  40                  45              


Thr Asp Tyr Asn Leu Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Ser Pro Asn His Gly Tyr Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys 
        115                 120                 125             


Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 Humanized 2G1 VL-1901 variant (E->H mutation in CDR3) (amino
       acid)

<400>  29

Gln Gln His Asn His Tyr Pro Tyr Thr 
1               5                   


<210>  30
<211>  428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VL-1901 variant (E->H mutation in CDR3)

<400>  30
gtcagagccc tggggaggaa ctgctcagtt aggacccaga gggaaccatg gaagccccag       60

ctcagcttct cttcctcctg ctactctggc tcccagatac caccggagac atccagttga      120

cccagtctcc atccttcctg tctgcatctg taggagacag agtcaccatc acttgcagga      180

caagtaagag cataagcaaa tatttagcct ggtatcagca aaaaccaggg aaagccccta      240

agctcctgat ctattctgga tccaccttgc aatctggggt cccatcaagg ttcagcggca      300

gtggatctgg gacagaattc actctcacaa tcagcagcct gcagcctgaa gattttgcaa      360

cttattactg tcaacaacat aatcattacc cgtacacgtt tggccagggg accaagctgg      420

agatcaaa                                                               428


<210>  31
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VL-1901 variant (E->H mutation in CDR3) (amino 
       acid)

<400>  31

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Lys Ser 
        35                  40                  45              


Ile Ser Lys Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asn 
            100                 105                 110         


His Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  32
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 Constant Heavy chain region (amino acid)

<400>  32

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Pro Gly Lys 
                325         


<210>  33
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 Constant Heavy chain region with S228P mutation (amino
       acid)

<400>  33

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Pro Gly Lys 
                325         


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 Humanized 2G1 VH-11801 variant (T->H mutation in CDR2)

<400>  34

Asp Ile Ser Pro Asn Tyr Gly Tyr His Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  35
<211>  482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VH-11801 variant (T->H mutation in CDR2)

<400>  35
cagcatatga tcagtgtcct ctccaaagtc cttgaacata gactctaacc atggactgga       60

cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag gttcagctgg      120

tgcagtctgg agctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggctt      180

ctggatacac aatcacagac tacaatttgg actgggtgcg acaggcccct ggacaagggc      240

ttgagtggat gggagatatt agtcctaact atggttatca tatctacaac cagaaattca      300

aggacagagt caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga      360

gcctgagatc tgacgacacg gccgtgtatt actgtgcgag aagggacatt cgttactccg      420

gtaattccta caaatggtac ttcgatgtct ggggccaagg gacaatggtc accgtctctt      480

ca                                                                     482


<210>  36
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 2G1 VH-11801 variant (T->H mutation in CDR2) (amino 
       acid)

<400>  36

Met Asp Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile 
        35                  40                  45              


Thr Asp Tyr Asn Leu Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Ser Pro Asn Tyr Gly Tyr His Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys 
        115                 120                 125             


Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 IWW-VH (amino acid)

<400>  37

Gly Tyr Thr Ile Thr Asp Tyr His Ile Asp 
1               5                   10  


<210>  38
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 IWW-VH (amino acid)

<400>  38

Asp Ile Ser Trp Asn Tyr Gly Tyr Thr Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  39
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 IWW-VH (amino acid)

<400>  39

Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys Trp Tyr Phe Asp Trp 
1               5                   10                  15      


<210>  40
<211>  482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IWW-VH

<400>  40
cagcatatga tcagtgtcct ctccaaagtc cttgaacata gactctaacc atggactgga       60

cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag gttcagctgg      120

tgcagtctgg agctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggctt      180

ctggatacac aatcacagac taccatatcg actgggtgcg acaggcccct ggacaagggc      240

ttgagtggat gggagatatt agttggaact atggttatac tatctacaac cagaaattca      300

aggacagagt caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga      360

gcctgagatc tgacgacacg gccgtgtatt actgtgcgag aagggacatt cgttactccg      420

gtaattccta caaatggtac ttcgattggt ggggccaagg gacaatggtc accgtctctt      480

ca                                                                     482


<210>  41
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IWW-VH (amino acid)

<400>  41

Met Asp Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile 
        35                  40                  45              


Thr Asp Tyr His Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Ser Trp Asn Tyr Gly Tyr Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys 
        115                 120                 125             


Trp Tyr Phe Asp Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 IFW-VH (amino acid)

<400>  42

Gly Tyr Thr Ile Thr Asp Tyr His Ile Asp 
1               5                   10  


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 IFW-VH (amino acid)

<400>  43

Asp Ile Ser Phe Asn Tyr Gly Tyr Thr Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  44
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 IFW-VH (amino acid)

<400>  44

Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys Trp Tyr Phe Asp Trp 
1               5                   10                  15      


<210>  45
<211>  482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IFW-VH

<400>  45
cagcatatga tcagtgtcct ctccaaagtc cttgaacata gactctaacc atggactgga       60

cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag gttcagctgg      120

tgcagtctgg agctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggctt      180

ctggatacac aatcacagac taccatatcg actgggtgcg acaggcccct ggacaagggc      240

ttgagtggat gggagatatt agtttcaact atggttatac tatctacaac cagaaattca      300

aggacagagt caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga      360

gcctgagatc tgacgacacg gccgtgtatt actgtgcgag aagggacatt cgttactccg      420

gtaattccta caaatggtac ttcgattggt ggggccaagg gacaatggtc accgtctctt      480

ca                                                                     482


<210>  46
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFW-VH (amino acid)

<400>  46

Met Asp Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile 
        35                  40                  45              


Thr Asp Tyr His Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Ser Phe Asn Tyr Gly Tyr Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys 
        115                 120                 125             


Trp Tyr Phe Asp Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 FME-VH (amino acid)

<400>  47

Gly Tyr Thr Ile Thr Asp Tyr His Phe Asp 
1               5                   10  


<210>  48
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 FME-VH (amino acid)

<400>  48

Asp Ile Ser Met Asn Tyr Gly Tyr Thr Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 FME-VH (amino acid)

<400>  49

Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys Trp Tyr Phe Asp Glu 
1               5                   10                  15      


<210>  50
<211>  482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FME-VH

<400>  50
cagcatatga tcagtgtcct ctccaaagtc cttgaacata gactctaacc atggactgga       60

cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag gttcagctgg      120

tgcagtctgg agctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggctt      180

ctggatacac aatcacagac taccatttcg actgggtgcg acaggcccct ggacaagggc      240

ttgagtggat gggagatatt agtatgaact atggttatac tatctacaac cagaaattca      300

aggacagagt caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga      360

gcctgagatc tgacgacacg gccgtgtatt actgtgcgag aagggacatt cgttactccg      420

gtaattccta caaatggtac ttcgatgagt ggggccaagg gacaatggtc accgtctctt      480

ca                                                                     482


<210>  51
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FME-VH (amino acid)

<400>  51

Met Asp Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile 
        35                  40                  45              


Thr Asp Tyr His Phe Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Ser Met Asn Tyr Gly Tyr Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys 
        115                 120                 125             


Trp Tyr Phe Asp Glu Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  52
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 FMW-VH (amino acid)

<400>  52

Gly Tyr Thr Ile Thr Asp Tyr His Phe Asp 
1               5                   10  


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 FMW-VH (amino acid)

<400>  53

Asp Ile Ser Met Asn Tyr Gly Tyr Thr Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  54
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 FMW-VH (amino acid)

<400>  54

Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys Trp Tyr Phe Asp Trp 
1               5                   10                  15      


<210>  55
<211>  482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FMW-VH

<400>  55
cagcatatga tcagtgtcct ctccaaagtc cttgaacata gactctaacc atggactgga       60

cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag gttcagctgg      120

tgcagtctgg agctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggctt      180

ctggatacac aatcacagac taccatttcg actgggtgcg acaggcccct ggacaagggc      240

ttgagtggat gggagatatt agtatgaact atggttatac tatctacaac cagaaattca      300

aggacagagt caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga      360

gcctgagatc tgacgacacg gccgtgtatt actgtgcgag aagggacatt cgttactccg      420

gtaattccta caaatggtac ttcgattggt ggggccaagg gacaatggtc accgtctctt      480

ca                                                                     482


<210>  56
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMW-VH (amino acid)

<400>  56

Met Asp Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile 
        35                  40                  45              


Thr Asp Tyr His Phe Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Ser Met Asn Tyr Gly Tyr Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys 
        115                 120                 125             


Trp Tyr Phe Asp Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  57
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 FMEH-VH (amino acid)

<400>  57

Asp Ile Ser Met Asn Tyr Gly Tyr His Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  58
<211>  482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FMEH-VH

<400>  58
cagcatatga tcagtgtcct ctccaaagtc cttgaacata gactctaacc atggactgga       60

cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag gttcagctgg      120

tgcagtctgg agctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggctt      180

ctggatacac aatcacagac taccatttcg actgggtgcg acaggcccct ggacaagggc      240

ttgagtggat gggagatatt agtatgaact atggttatca tatctacaac cagaaattca      300

aggacagagt caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga      360

gcctgagatc tgacgacacg gccgtgtatt actgtgcgag aagggacatt cgttactccg      420

gtaattccta caaatggtac ttcgatgagt ggggccaagg gacaatggtc accgtctctt      480

ca                                                                     482


<210>  59
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMEH-VH (amino acid)

<400>  59

Met Asp Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile 
        35                  40                  45              


Thr Asp Tyr His Phe Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Ser Met Asn Tyr Gly Tyr His Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys 
        115                 120                 125             


Trp Tyr Phe Asp Glu Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  60
<211>  984
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG4 Fc PLA domain mutation

<400>  60
gctagcacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc accatgccca gcacctgagt tcctgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaggctc accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gctgcatgag gctctgcacg cccactacac acagaagagc      960

ctctccctgt ctctgggtaa atga                                             984


<210>  61
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 Fc PLA domain mutation (amino acid)

<400>  61

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Leu His Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  62
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 IWWH-VH (amino acid)

<400>  62

Asp Ile Ser Trp Asn Tyr Gly Tyr His Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  63
<211>  482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IWWH-VH

<400>  63
cagcatatga tcagtgtcct ctccaaagtc cttgaacata gactctaacc atggactgga       60

cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag gttcagctgg      120

tgcagtctgg agctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggctt      180

ctggatacac aatcacagac taccatatcg actgggtgcg acaggcccct ggacaagggc      240

ttgagtggat gggagatatt agttggaact atggttatca tatctacaac cagaaattca      300

aggacagagt caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga      360

gcctgagatc tgacgacacg gccgtgtatt actgtgcgag aagggacatt cgttactccg      420

gtaattccta caaatggtac ttcgattggt ggggccaagg gacaatggtc accgtctctt      480

ca                                                                     482


<210>  64
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IWWH-VH (amino acid)

<400>  64

Met Asp Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile 
        35                  40                  45              


Thr Asp Tyr His Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Ser Trp Asn Tyr Gly Tyr His Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys 
        115                 120                 125             


Trp Tyr Phe Asp Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  65
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 IFWH-VH (amino acid)

<400>  65

Asp Ile Ser Phe Asn Tyr Gly Tyr His Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  66
<211>  482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IFWH-VH

<400>  66
cagcatatga tcagtgtcct ctccaaagtc cttgaacata gactctaacc atggactgga       60

cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag gttcagctgg      120

tgcagtctgg agctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggctt      180

ctggatacac aatcacagac taccatatcg actgggtgcg acaggcccct ggacaagggc      240

ttgagtggat gggagatatt agtttcaact atggttatca tatctacaac cagaaattca      300

aggacagagt caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga      360

gcctgagatc tgacgacacg gccgtgtatt actgtgcgag aagggacatt cgttactccg      420

gtaattccta caaatggtac ttcgattggt ggggccaagg gacaatggtc accgtctctt      480

ca                                                                     482


<210>  67
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFWH-VH (amino acid)

<400>  67

Met Asp Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile 
        35                  40                  45              


Thr Asp Tyr His Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Ser Phe Asn Tyr Gly Tyr His Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys 
        115                 120                 125             


Trp Tyr Phe Asp Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  68
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 FMWH-VH (amino acid)

<400>  68

Asp Ile Ser Met Asn Tyr Gly Tyr His Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  69
<211>  482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FMWH-VH

<400>  69
cagcatatga tcagtgtcct ctccaaagtc cttgaacata gactctaacc atggactgga       60

cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag gttcagctgg      120

tgcagtctgg agctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggctt      180

ctggatacac aatcacagac taccatttcg actgggtgcg acaggcccct ggacaagggc      240

ttgagtggat gggagatatt agtatgaact atggttatca tatctacaac cagaaattca      300

aggacagagt caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga      360

gcctgagatc tgacgacacg gccgtgtatt actgtgcgag aagggacatt cgttactccg      420

gtaattccta caaatggtac ttcgattggt ggggccaagg gacaatggtc accgtctctt      480

ca                                                                     482


<210>  70
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMWH-VH (amino acid)

<400>  70

Met Asp Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile 
        35                  40                  45              


Thr Asp Tyr His Phe Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Ser Met Asn Tyr Gly Tyr His Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys 
        115                 120                 125             


Trp Tyr Phe Asp Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  71
<211>  2384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH sequence of FMEH-IgG4PLA-FH1-5

<400>  71
cagcatatga tcagtgtcct ctccaaagtc cttgaacata gactctaacc atggactgga       60

cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag gttcagctgg      120

tgcagtctgg agctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggctt      180

ctggatacac aatcacagac taccatttcg actgggtgcg acaggcccct ggacaagggc      240

ttgagtggat gggagatatt agtatgaact atggttatca tatctacaac cagaaattca      300

aggacagagt caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga      360

gcctgagatc tgacgacacg gccgtgtatt actgtgcgag aagggacatt cgttactccg      420

gtaattccta caaatggtac ttcgatgagt ggggccaagg gacaatggtc accgtctctt      480

cagctagcac caagggccca tcggtcttcc ccctggcgcc ctgctccagg agcacctccg      540

agagcacagc cgccctgggc tgcctggtca aggactactt ccccgaaccg gtgacggtgt      600

cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc ctacagtcct      660

caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg ggcacgaaga      720

cctacacctg caacgtagat cacaagccca gcaacaccaa ggtggacaag agagttgagt      780

ccaaatatgg tcccccatgc ccaccatgcc cagcacctga gttcctgggg ggaccatcag      840

tcttcctgtt ccccccaaaa cccaaggaca ctctcatgat ctcccggacc cctgaggtca      900

cgtgcgtggt ggtggacgtg agccaggaag accccgaggt ccagttcaac tggtacgtgg      960

atggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagttc aacagcacgt     1020

accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaacggc aaggagtaca     1080

agtgcaaggt ctccaacaaa ggcctcccgt cctccatcga gaaaaccatc tccaaagcca     1140

aagggcagcc ccgagagcca caggtgtaca ccctgccccc atcccaggag gagatgacca     1200

agaaccaggt cagcctgacc tgcctggtca aaggcttcta ccccagcgac atcgccgtgg     1260

agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc gtgctggact     1320

ccgacggctc cttcttcctc tacagcaggc tcaccgtgga caagagcagg tggcaggagg     1380

ggaatgtctt ctcatgctcc gtgctgcatg aggctctgca cgcccactac acacagaaga     1440

gcctctccct gtctctgggt aaagaggatt gtaatgaact gcctccaaga aggaacacag     1500

aaattttgac cgggtcctgg tccgatcaaa cctaccctga aggaactcaa gctatataca     1560

agtgcagacc tggttataga tcactgggca acattatcat ggtatgtcgc aaaggagaat     1620

gggtggctct gaatcccctc agaaaatgcc agaaacggcc atgtggacac cccggcgata     1680

ccccattcgg gacatttacc ttgactggag gcaatgtatt cgagtatggc gtgaaagctg     1740

tctatacctg taacgaaggt taccaattgt tgggagaaat aaattacaga gaatgtgata     1800

ccgatggatg gaccaacgat attcccatat gcgaggttgt taagtgcttg cctgtcactg     1860

caccagaaaa cgggaaaatc gtatctagcg caatggagcc agaccgcgaa taccatttcg     1920

ggcaggcagt gaggtttgtt tgcaattccg gttataagat agaaggggat gaggagatgc     1980

actgtagcga cgatggtttt tggtccaagg aaaagcccaa gtgcgtcgaa ataagttgca     2040

agtcacctga cgtcataaac gggagcccca tatcccaaaa gataatttac aaggagaacg     2100

aacgatttca atataagtgt aatatggggt atgaatactc cgagagaggt gatgccgtct     2160

gtaccgaaag tggatggcga ccactcccct catgcgaaga gaagtcctgt gataatccat     2220

acatccctaa tggtgattat tccccccttc gaataaagca tcggacagga gacgagatca     2280

catatcagtg tcgcaacgga ttctatccag ccaccagagg caacactgca aagtgtacat     2340

ctacaggatg gatacctgcc ccacgatgta ccttgaagcc ctga                      2384


<210>  72
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence of FMEH-IgG4PLA-FH1-5  (amino acid)

<400>  72

Met Asp Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile 
        35                  40                  45              


Thr Asp Tyr His Phe Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Ser Met Asn Tyr Gly Tyr His Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys 
        115                 120                 125             


Trp Tyr Phe Asp Glu Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
    210                 215                 220                 


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            340                 345                 350         


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Leu His Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Leu Gly Lys Glu Asp Cys Asn Glu Leu Pro Pro Arg 
465                 470                 475                 480 


Arg Asn Thr Glu Ile Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro 
                485                 490                 495     


Glu Gly Thr Gln Ala Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu 
            500                 505                 510         


Gly Asn Ile Ile Met Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn 
        515                 520                 525             


Pro Leu Arg Lys Cys Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr 
    530                 535                 540                 


Pro Phe Gly Thr Phe Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly 
545                 550                 555                 560 


Val Lys Ala Val Tyr Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu 
                565                 570                 575     


Ile Asn Tyr Arg Glu Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro 
            580                 585                 590         


Ile Cys Glu Val Val Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly 
        595                 600                 605             


Lys Ile Val Ser Ser Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly 
    610                 615                 620                 


Gln Ala Val Arg Phe Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp 
625                 630                 635                 640 


Glu Glu Met His Cys Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro 
                645                 650                 655     


Lys Cys Val Glu Ile Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser 
            660                 665                 670         


Pro Ile Ser Gln Lys Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr 
        675                 680                 685             


Lys Cys Asn Met Gly Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys 
    690                 695                 700                 


Thr Glu Ser Gly Trp Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys 
705                 710                 715                 720 


Asp Asn Pro Tyr Ile Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys 
                725                 730                 735     


His Arg Thr Gly Asp Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr 
            740                 745                 750         


Pro Ala Thr Arg Gly Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile 
        755                 760                 765             


Pro Ala Pro Arg Cys Thr Leu Lys Pro 
    770                 775         


<210>  73
<211>  752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL sequence of FMEH-IgG4-FH1-5

<400>  73
gtcagagccc tggggaggaa ctgctcagtt aggacccaga gggaaccatg gaagccccag       60

ctcagcttct cttcctcctg ctactctggc tcccagatac caccggagac atccagttga      120

cccagtctcc atccttcctg tctgcatctg taggagacag agtcaccatc acttgcagga      180

caagtaagag cataagcaaa catttagcct ggtatcagca aaaaccaggg aaagccccta      240

agctcctgat ctattctgga tccaccttgc aatctggggt cccatcaagg ttcagcggca      300

gtggatctgg gacagaattc actctcacaa tcagcagcct gcagcctgaa gattttgcaa      360

cttattactg tcaacaacat aatgaatacc cgtacacgtt tggccagggg accaagctgg      420

agatcaaacg tacggtggct gcaccatctg tcttcatctt cccgccatct gatgagcagt      480

tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc agagaggcca      540

aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag agtgtcacag      600

agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg agcaaagcag      660

actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg agctcgcccg      720

tcacaaagag cttcaacagg ggagagtgtt ag                                    752


<210>  74
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence of FMEH-IgG4-FH1-5 (amino acid)

<400>  74

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Lys Ser 
        35                  40                  45              


Ile Ser Lys His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asn 
            100                 105                 110         


Glu Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  75
<211>  2384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH sequence of IWWH-IgG4PLA-FH1-5

<400>  75
cagcatatga tcagtgtcct ctccaaagtc cttgaacata gactctaacc atggactgga       60

cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag gttcagctgg      120

tgcagtctgg agctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggctt      180

ctggatacac aatcacagac taccatatcg actgggtgcg acaggcccct ggacaagggc      240

ttgagtggat gggagatatt agttggaact atggttatca tatctacaac cagaaattca      300

aggacagagt caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga      360

gcctgagatc tgacgacacg gccgtgtatt actgtgcgag aagggacatt cgttactccg      420

gtaattccta caaatggtac ttcgattggt ggggccaagg gacaatggtc accgtctctt      480

cagctagcac caagggccca tcggtcttcc ccctggcgcc ctgctccagg agcacctccg      540

agagcacagc cgccctgggc tgcctggtca aggactactt ccccgaaccg gtgacggtgt      600

cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc ctacagtcct      660

caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg ggcacgaaga      720

cctacacctg caacgtagat cacaagccca gcaacaccaa ggtggacaag agagttgagt      780

ccaaatatgg tcccccatgc ccaccatgcc cagcacctga gttcctgggg ggaccatcag      840

tcttcctgtt ccccccaaaa cccaaggaca ctctcatgat ctcccggacc cctgaggtca      900

cgtgcgtggt ggtggacgtg agccaggaag accccgaggt ccagttcaac tggtacgtgg      960

atggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagttc aacagcacgt     1020

accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaacggc aaggagtaca     1080

agtgcaaggt ctccaacaaa ggcctcccgt cctccatcga gaaaaccatc tccaaagcca     1140

aagggcagcc ccgagagcca caggtgtaca ccctgccccc atcccaggag gagatgacca     1200

agaaccaggt cagcctgacc tgcctggtca aaggcttcta ccccagcgac atcgccgtgg     1260

agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc gtgctggact     1320

ccgacggctc cttcttcctc tacagcaggc tcaccgtgga caagagcagg tggcaggagg     1380

ggaatgtctt ctcatgctcc gtgctgcatg aggctctgca cgcccactac acacagaaga     1440

gcctctccct gtctctgggt aaagaggatt gtaatgaact gcctccaaga aggaacacag     1500

aaattttgac cgggtcctgg tccgatcaaa cctaccctga aggaactcaa gctatataca     1560

agtgcagacc tggttataga tcactgggca acattatcat ggtatgtcgc aaaggagaat     1620

gggtggctct gaatcccctc agaaaatgcc agaaacggcc atgtggacac cccggcgata     1680

ccccattcgg gacatttacc ttgactggag gcaatgtatt cgagtatggc gtgaaagctg     1740

tctatacctg taacgaaggt taccaattgt tgggagaaat aaattacaga gaatgtgata     1800

ccgatggatg gaccaacgat attcccatat gcgaggttgt taagtgcttg cctgtcactg     1860

caccagaaaa cgggaaaatc gtatctagcg caatggagcc agaccgcgaa taccatttcg     1920

ggcaggcagt gaggtttgtt tgcaattccg gttataagat agaaggggat gaggagatgc     1980

actgtagcga cgatggtttt tggtccaagg aaaagcccaa gtgcgtcgaa ataagttgca     2040

agtcacctga cgtcataaac gggagcccca tatcccaaaa gataatttac aaggagaacg     2100

aacgatttca atataagtgt aatatggggt atgaatactc cgagagaggt gatgccgtct     2160

gtaccgaaag tggatggcga ccactcccct catgcgaaga gaagtcctgt gataatccat     2220

acatccctaa tggtgattat tccccccttc gaataaagca tcggacagga gacgagatca     2280

catatcagtg tcgcaacgga ttctatccag ccaccagagg caacactgca aagtgtacat     2340

ctacaggatg gatacctgcc ccacgatgta ccttgaagcc ctga                      2384


<210>  76
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence of IWWH-IgG4PLA-FH1-5 (amino acid)

<400>  76

Met Asp Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile 
        35                  40                  45              


Thr Asp Tyr His Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Ser Trp Asn Tyr Gly Tyr His Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys 
        115                 120                 125             


Trp Tyr Phe Asp Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
    210                 215                 220                 


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            340                 345                 350         


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Leu His Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Leu Gly Lys Glu Asp Cys Asn Glu Leu Pro Pro Arg 
465                 470                 475                 480 


Arg Asn Thr Glu Ile Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro 
                485                 490                 495     


Glu Gly Thr Gln Ala Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu 
            500                 505                 510         


Gly Asn Ile Ile Met Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn 
        515                 520                 525             


Pro Leu Arg Lys Cys Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr 
    530                 535                 540                 


Pro Phe Gly Thr Phe Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly 
545                 550                 555                 560 


Val Lys Ala Val Tyr Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu 
                565                 570                 575     


Ile Asn Tyr Arg Glu Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro 
            580                 585                 590         


Ile Cys Glu Val Val Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly 
        595                 600                 605             


Lys Ile Val Ser Ser Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly 
    610                 615                 620                 


Gln Ala Val Arg Phe Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp 
625                 630                 635                 640 


Glu Glu Met His Cys Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro 
                645                 650                 655     


Lys Cys Val Glu Ile Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser 
            660                 665                 670         


Pro Ile Ser Gln Lys Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr 
        675                 680                 685             


Lys Cys Asn Met Gly Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys 
    690                 695                 700                 


Thr Glu Ser Gly Trp Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys 
705                 710                 715                 720 


Asp Asn Pro Tyr Ile Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys 
                725                 730                 735     


His Arg Thr Gly Asp Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr 
            740                 745                 750         


Pro Ala Thr Arg Gly Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile 
        755                 760                 765             


Pro Ala Pro Arg Cys Thr Leu Lys Pro 
    770                 775         


<210>  77
<211>  2384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH sequence of IFWH-IgG4PLA-FH1-5

<400>  77
cagcatatga tcagtgtcct ctccaaagtc cttgaacata gactctaacc atggactgga       60

cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag gttcagctgg      120

tgcagtctgg agctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggctt      180

ctggatacac aatcacagac taccatatcg actgggtgcg acaggcccct ggacaagggc      240

ttgagtggat gggagatatt agtttcaact atggttatca tatctacaac cagaaattca      300

aggacagagt caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga      360

gcctgagatc tgacgacacg gccgtgtatt actgtgcgag aagggacatt cgttactccg      420

gtaattccta caaatggtac ttcgattggt ggggccaagg gacaatggtc accgtctctt      480

cagctagcac caagggccca tcggtcttcc ccctggcgcc ctgctccagg agcacctccg      540

agagcacagc cgccctgggc tgcctggtca aggactactt ccccgaaccg gtgacggtgt      600

cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc ctacagtcct      660

caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg ggcacgaaga      720

cctacacctg caacgtagat cacaagccca gcaacaccaa ggtggacaag agagttgagt      780

ccaaatatgg tcccccatgc ccaccatgcc cagcacctga gttcctgggg ggaccatcag      840

tcttcctgtt ccccccaaaa cccaaggaca ctctcatgat ctcccggacc cctgaggtca      900

cgtgcgtggt ggtggacgtg agccaggaag accccgaggt ccagttcaac tggtacgtgg      960

atggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagttc aacagcacgt     1020

accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaacggc aaggagtaca     1080

agtgcaaggt ctccaacaaa ggcctcccgt cctccatcga gaaaaccatc tccaaagcca     1140

aagggcagcc ccgagagcca caggtgtaca ccctgccccc atcccaggag gagatgacca     1200

agaaccaggt cagcctgacc tgcctggtca aaggcttcta ccccagcgac atcgccgtgg     1260

agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc gtgctggact     1320

ccgacggctc cttcttcctc tacagcaggc tcaccgtgga caagagcagg tggcaggagg     1380

ggaatgtctt ctcatgctcc gtgctgcatg aggctctgca cgcccactac acacagaaga     1440

gcctctccct gtctctgggt aaagaggatt gtaatgaact gcctccaaga aggaacacag     1500

aaattttgac cgggtcctgg tccgatcaaa cctaccctga aggaactcaa gctatataca     1560

agtgcagacc tggttataga tcactgggca acattatcat ggtatgtcgc aaaggagaat     1620

gggtggctct gaatcccctc agaaaatgcc agaaacggcc atgtggacac cccggcgata     1680

ccccattcgg gacatttacc ttgactggag gcaatgtatt cgagtatggc gtgaaagctg     1740

tctatacctg taacgaaggt taccaattgt tgggagaaat aaattacaga gaatgtgata     1800

ccgatggatg gaccaacgat attcccatat gcgaggttgt taagtgcttg cctgtcactg     1860

caccagaaaa cgggaaaatc gtatctagcg caatggagcc agaccgcgaa taccatttcg     1920

ggcaggcagt gaggtttgtt tgcaattccg gttataagat agaaggggat gaggagatgc     1980

actgtagcga cgatggtttt tggtccaagg aaaagcccaa gtgcgtcgaa ataagttgca     2040

agtcacctga cgtcataaac gggagcccca tatcccaaaa gataatttac aaggagaacg     2100

aacgatttca atataagtgt aatatggggt atgaatactc cgagagaggt gatgccgtct     2160

gtaccgaaag tggatggcga ccactcccct catgcgaaga gaagtcctgt gataatccat     2220

acatccctaa tggtgattat tccccccttc gaataaagca tcggacagga gacgagatca     2280

catatcagtg tcgcaacgga ttctatccag ccaccagagg caacactgca aagtgtacat     2340

ctacaggatg gatacctgcc ccacgatgta ccttgaagcc ctga                      2384


<210>  78
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence of IFWH-IgG4PLA-FH1-5 (amino acid)

<400>  78

Met Asp Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile 
        35                  40                  45              


Thr Asp Tyr His Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Ser Phe Asn Tyr Gly Tyr His Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys 
        115                 120                 125             


Trp Tyr Phe Asp Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
    210                 215                 220                 


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            340                 345                 350         


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Leu His Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Leu Gly Lys Glu Asp Cys Asn Glu Leu Pro Pro Arg 
465                 470                 475                 480 


Arg Asn Thr Glu Ile Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro 
                485                 490                 495     


Glu Gly Thr Gln Ala Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu 
            500                 505                 510         


Gly Asn Ile Ile Met Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn 
        515                 520                 525             


Pro Leu Arg Lys Cys Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr 
    530                 535                 540                 


Pro Phe Gly Thr Phe Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly 
545                 550                 555                 560 


Val Lys Ala Val Tyr Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu 
                565                 570                 575     


Ile Asn Tyr Arg Glu Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro 
            580                 585                 590         


Ile Cys Glu Val Val Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly 
        595                 600                 605             


Lys Ile Val Ser Ser Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly 
    610                 615                 620                 


Gln Ala Val Arg Phe Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp 
625                 630                 635                 640 


Glu Glu Met His Cys Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro 
                645                 650                 655     


Lys Cys Val Glu Ile Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser 
            660                 665                 670         


Pro Ile Ser Gln Lys Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr 
        675                 680                 685             


Lys Cys Asn Met Gly Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys 
    690                 695                 700                 


Thr Glu Ser Gly Trp Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys 
705                 710                 715                 720 


Asp Asn Pro Tyr Ile Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys 
                725                 730                 735     


His Arg Thr Gly Asp Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr 
            740                 745                 750         


Pro Ala Thr Arg Gly Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile 
        755                 760                 765             


Pro Ala Pro Arg Cys Thr Leu Lys Pro 
    770                 775         


<210>  79
<211>  2384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH sequence of FMWH-IgG4PLA-FH1-5

<400>  79
cagcatatga tcagtgtcct ctccaaagtc cttgaacata gactctaacc atggactgga       60

cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag gttcagctgg      120

tgcagtctgg agctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggctt      180

ctggatacac aatcacagac taccatttcg actgggtgcg acaggcccct ggacaagggc      240

ttgagtggat gggagatatt agtatgaact atggttatca tatctacaac cagaaattca      300

aggacagagt caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga      360

gcctgagatc tgacgacacg gccgtgtatt actgtgcgag aagggacatt cgttactccg      420

gtaattccta caaatggtac ttcgattggt ggggccaagg gacaatggtc accgtctctt      480

cagctagcac caagggccca tcggtcttcc ccctggcgcc ctgctccagg agcacctccg      540

agagcacagc cgccctgggc tgcctggtca aggactactt ccccgaaccg gtgacggtgt      600

cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc ctacagtcct      660

caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg ggcacgaaga      720

cctacacctg caacgtagat cacaagccca gcaacaccaa ggtggacaag agagttgagt      780

ccaaatatgg tcccccatgc ccaccatgcc cagcacctga gttcctgggg ggaccatcag      840

tcttcctgtt ccccccaaaa cccaaggaca ctctcatgat ctcccggacc cctgaggtca      900

cgtgcgtggt ggtggacgtg agccaggaag accccgaggt ccagttcaac tggtacgtgg      960

atggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagttc aacagcacgt     1020

accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaacggc aaggagtaca     1080

agtgcaaggt ctccaacaaa ggcctcccgt cctccatcga gaaaaccatc tccaaagcca     1140

aagggcagcc ccgagagcca caggtgtaca ccctgccccc atcccaggag gagatgacca     1200

agaaccaggt cagcctgacc tgcctggtca aaggcttcta ccccagcgac atcgccgtgg     1260

agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc gtgctggact     1320

ccgacggctc cttcttcctc tacagcaggc tcaccgtgga caagagcagg tggcaggagg     1380

ggaatgtctt ctcatgctcc gtgctgcatg aggctctgca cgcccactac acacagaaga     1440

gcctctccct gtctctgggt aaagaggatt gtaatgaact gcctccaaga aggaacacag     1500

aaattttgac cgggtcctgg tccgatcaaa cctaccctga aggaactcaa gctatataca     1560

agtgcagacc tggttataga tcactgggca acattatcat ggtatgtcgc aaaggagaat     1620

gggtggctct gaatcccctc agaaaatgcc agaaacggcc atgtggacac cccggcgata     1680

ccccattcgg gacatttacc ttgactggag gcaatgtatt cgagtatggc gtgaaagctg     1740

tctatacctg taacgaaggt taccaattgt tgggagaaat aaattacaga gaatgtgata     1800

ccgatggatg gaccaacgat attcccatat gcgaggttgt taagtgcttg cctgtcactg     1860

caccagaaaa cgggaaaatc gtatctagcg caatggagcc agaccgcgaa taccatttcg     1920

ggcaggcagt gaggtttgtt tgcaattccg gttataagat agaaggggat gaggagatgc     1980

actgtagcga cgatggtttt tggtccaagg aaaagcccaa gtgcgtcgaa ataagttgca     2040

agtcacctga cgtcataaac gggagcccca tatcccaaaa gataatttac aaggagaacg     2100

aacgatttca atataagtgt aatatggggt atgaatactc cgagagaggt gatgccgtct     2160

gtaccgaaag tggatggcga ccactcccct catgcgaaga gaagtcctgt gataatccat     2220

acatccctaa tggtgattat tccccccttc gaataaagca tcggacagga gacgagatca     2280

catatcagtg tcgcaacgga ttctatccag ccaccagagg caacactgca aagtgtacat     2340

ctacaggatg gatacctgcc ccacgatgta ccttgaagcc ctga                      2384


<210>  80
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence of FMWH-IgG4PLA-FH1-5 (amino acid)

<400>  80

Met Asp Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile 
        35                  40                  45              


Thr Asp Tyr His Phe Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Ser Met Asn Tyr Gly Tyr His Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ile Arg Tyr Ser Gly Asn Ser Tyr Lys 
        115                 120                 125             


Trp Tyr Phe Asp Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
    210                 215                 220                 


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            340                 345                 350         


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Leu His Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Leu Gly Lys Glu Asp Cys Asn Glu Leu Pro Pro Arg 
465                 470                 475                 480 


Arg Asn Thr Glu Ile Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro 
                485                 490                 495     


Glu Gly Thr Gln Ala Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu 
            500                 505                 510         


Gly Asn Ile Ile Met Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn 
        515                 520                 525             


Pro Leu Arg Lys Cys Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr 
    530                 535                 540                 


Pro Phe Gly Thr Phe Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly 
545                 550                 555                 560 


Val Lys Ala Val Tyr Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu 
                565                 570                 575     


Ile Asn Tyr Arg Glu Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro 
            580                 585                 590         


Ile Cys Glu Val Val Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly 
        595                 600                 605             


Lys Ile Val Ser Ser Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly 
    610                 615                 620                 


Gln Ala Val Arg Phe Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp 
625                 630                 635                 640 


Glu Glu Met His Cys Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro 
                645                 650                 655     


Lys Cys Val Glu Ile Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser 
            660                 665                 670         


Pro Ile Ser Gln Lys Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr 
        675                 680                 685             


Lys Cys Asn Met Gly Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys 
    690                 695                 700                 


Thr Glu Ser Gly Trp Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys 
705                 710                 715                 720 


Asp Asn Pro Tyr Ile Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys 
                725                 730                 735     


His Arg Thr Gly Asp Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr 
            740                 745                 750         


Pro Ala Thr Arg Gly Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile 
        755                 760                 765             


Pro Ala Pro Arg Cys Thr Leu Lys Pro 
    770                 775         


<210>  81
<211>  1231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid sequence of P08603-1; Human Complement Factor H 
       Isoform 1, precursor

<400>  81

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     


<210>  82
<211>  1213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid sequence of P08603-1; Human Complement Factor H 
       Isoform 1

<400>  82

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     


Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         


Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             


Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 


Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu 
305                 310                 315                 320 


Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser 
                325                 330                 335     


Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp 
            340                 345                 350         


His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu 
        355                 360                 365             


Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr 
    370                 375                 380                 


Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro 
385                 390                 395                 400 


Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn 
                405                 410                 415     


Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys Ser Lys 
            420                 425                 430         


Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln Tyr Thr 
        435                 440                 445             


Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly Tyr Val 
    450                 455                 460                 


Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys Asp Gly 
465                 470                 475                 480 


Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro Val Phe 
                485                 490                 495     


Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu Asn Asp 
            500                 505                 510         


Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr Gly Ser 
        515                 520                 525             


Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp Leu Pro 
    530                 535                 540                 


Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val His Leu 
545                 550                 555                 560 


Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val Leu Lys 
                565                 570                 575     


Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser Val Gln 
            580                 585                 590         


Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys Glu Gln 
        595                 600                 605             


Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn Val Lys 
    610                 615                 620                 


Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu Tyr Tyr 
625                 630                 635                 640 


Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln Cys Val 
                645                 650                 655     


Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu Ser Thr 
            660                 665                 670         


Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu Ser Ser 
        675                 680                 685             


Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser Glu Ser 
    690                 695                 700                 


Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly Val Trp 
705                 710                 715                 720 


Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys Cys Lys 
                725                 730                 735     


Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys Lys Glu 
            740                 745                 750         


Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly 
        755                 760                 765             


Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu Val Asn 
    770                 775                 780                 


Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro 
785                 790                 795                 800 


Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys 
                805                 810                 815     


Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu 
            820                 825                 830         


Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu 
        835                 840                 845             


Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn 
    850                 855                 860                 


Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser 
865                 870                 875                 880 


Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr 
                885                 890                 895     


Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro 
            900                 905                 910         


Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser 
        915                 920                 925             


Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly 
    930                 935                 940                 


Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp 
945                 950                 955                 960 


Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser 
                965                 970                 975     


Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala 
            980                 985                 990         


Gly Glu Gln Val Thr Tyr Thr Cys  Ala Thr Tyr Tyr Lys  Met Asp Gly 
        995                 1000                 1005             


Ala Ser  Asn Val Thr Cys Ile  Asn Ser Arg Trp Thr  Gly Arg Pro 
    1010                 1015                 1020             


Thr Cys  Arg Asp Thr Ser Cys  Val Asn Pro Pro Thr  Val Gln Asn 
    1025                 1030                 1035             


Ala Tyr  Ile Val Ser Arg Gln  Met Ser Lys Tyr Pro  Ser Gly Glu 
    1040                 1045                 1050             


Arg Val  Arg Tyr Gln Cys Arg  Ser Pro Tyr Glu Met  Phe Gly Asp 
    1055                 1060                 1065             


Glu Glu  Val Met Cys Leu Asn  Gly Asn Trp Thr Glu  Pro Pro Gln 
    1070                 1075                 1080             


Cys Lys  Asp Ser Thr Gly Lys  Cys Gly Pro Pro Pro  Pro Ile Asp 
    1085                 1090                 1095             


Asn Gly  Asp Ile Thr Ser Phe  Pro Leu Ser Val Tyr  Ala Pro Ala 
    1100                 1105                 1110             


Ser Ser  Val Glu Tyr Gln Cys  Gln Asn Leu Tyr Gln  Leu Glu Gly 
    1115                 1120                 1125             


Asn Lys  Arg Ile Thr Cys Arg  Asn Gly Gln Trp Ser  Glu Pro Pro 
    1130                 1135                 1140             


Lys Cys  Leu His Pro Cys Val  Ile Ser Arg Glu Ile  Met Glu Asn 
    1145                 1150                 1155             


Tyr Asn  Ile Ala Leu Arg Trp  Thr Ala Lys Gln Lys  Leu Tyr Ser 
    1160                 1165                 1170             


Arg Thr  Gly Glu Ser Val Glu  Phe Val Cys Lys Arg  Gly Tyr Arg 
    1175                 1180                 1185             


Leu Ser  Ser Arg Ser His Thr  Leu Arg Thr Thr Cys  Trp Asp Gly 
    1190                 1195                 1200             


Lys Leu  Glu Tyr Pro Thr Cys  Ala Lys Arg 
    1205                 1210             


<210>  83
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid sequence of P08603-2; Human Complement Factor H 
       Isoform 2, precursor

<400>  83

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe Thr 
        435                 440                 445             


Leu 
    


<210>  84
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid sequence of P08603-2; Human Complement Factor H 
       Isoform 2

<400>  84

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     


Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         


Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             


Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 


Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu 
305                 310                 315                 320 


Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser 
                325                 330                 335     


Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp 
            340                 345                 350         


His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu 
        355                 360                 365             


Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr 
    370                 375                 380                 


Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro 
385                 390                 395                 400 


Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn 
                405                 410                 415     


Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe Thr Leu 
            420                 425                 430     


