                         SEQUENCE LISTING

<110>  Beijing Xuanyi PharmaSciences Co., Ltd.
 
<120>  CD80 VARIANT PROTEINS AND USES THEREOF

<130>  CSPL-009/01WO 332638-2043

<150>  US 62/839,542
<151>  2019-04-26

<160>  85    

<170>  PatentIn version 3.5

<210>  1
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  1

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  3
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  3

Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                165                 170                 175     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220             


<210>  4
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Phe 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro 
                165                 170                 175     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  5
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  5

Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
        35                  40                  45              


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Leu Gly Lys 
225         


<210>  6
<211>  220
<212>  PRT
<213>  Mus musculus

<400>  6

Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
        35                  40                  45              


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
    50                  55                  60                  


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
65                  70                  75                  80  


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
                85                  90                  95      


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
            100                 105                 110         


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
        115                 120                 125             


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
    130                 135                 140                 


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
145                 150                 155                 160 


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn Gly Ser 
                165                 170                 175     


Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
            180                 185                 190         


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
        195                 200                 205             


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  7
<211>  230
<212>  PRT
<213>  Mus musculus

<400>  7

Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
1               5                   10                  15      


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
            20                  25                  30          


Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp 
        35                  40                  45              


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
    50                  55                  60                  


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
65                  70                  75                  80  


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
                85                  90                  95      


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro 
            100                 105                 110         


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
        115                 120                 125             


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
    130                 135                 140                 


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
145                 150                 155                 160 


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
                165                 170                 175     


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
            180                 185                 190         


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
        195                 200                 205             


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
    210                 215                 220                 


Ser Arg Thr Pro Gly Lys 
225                 230 


<210>  8
<211>  302
<212>  PRT
<213>  Mus musculus

<400>  8

Ser Thr Ile Asn Pro Cys Pro Pro Cys Lys Glu Cys His Lys Cys Pro 
1               5                   10                  15      


Ala Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn 
            20                  25                  30          


Ile Lys Asp Val Leu Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    50                  55                  60                  


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
65                  70                  75                  80  


Asp Tyr Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Gln His 
                85                  90                  95      


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ile Lys Gly Leu 
        115                 120                 125             


Val Arg Ala Pro Gln Val Tyr Ile Leu Pro Pro Pro Ala Glu Gln Leu 
    130                 135                 140                 


Ser Arg Lys Asp Val Ser Leu Thr Cys Leu Val Val Gly Phe Asn Pro 
145                 150                 155                 160 


Gly Asp Ile Ser Val Glu Trp Thr Ser Asn Gly His Thr Glu Glu Asn 
                165                 170                 175     


Tyr Lys Asp Thr Ala Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Ile 
            180                 185                 190         


Tyr Ser Lys Leu Asn Met Lys Thr Ser Lys Trp Glu Lys Thr Asp Ser 
        195                 200                 205             


Phe Ser Cys Asn Val Arg His Glu Gly Leu Lys Asn Tyr Tyr Leu Lys 
    210                 215                 220                 


Lys Thr Ile Ser Arg Ser Pro Gly Leu Asp Leu Asp Asp Ile Cys Ala 
225                 230                 235                 240 


Glu Ala Lys Asp Gly Glu Leu Asp Gly Leu Trp Thr Thr Ile Thr Ile 
                245                 250                 255     


Phe Ile Ser Leu Phe Leu Leu Ser Val Cys Tyr Ser Ala Ser Val Thr 
            260                 265                 270         


Leu Phe Lys Val Lys Trp Ile Phe Ser Ser Val Val Glu Leu Lys Gln 
        275                 280                 285             


Lys Ile Ser Pro Asp Tyr Arg Asn Met Ile Gly Gln Gly Ala 
    290                 295                 300         


<210>  9
<211>  295
<212>  PRT
<213>  Mus musculus

<400>  9

Ser Thr Pro Pro Gly Ser Ser Cys Pro Pro Gly Asn Ile Leu Gly Gly 
1               5                   10                  15      


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Ala Leu Met Ile 
            20                  25                  30          


Ser Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Val Ser Glu Asp 
        35                  40                  45              


Asp Pro Asp Val His Val Ser Trp Phe Val Asp Asn Lys Glu Val His 
    50                  55                  60                  


Thr Ala Trp Thr Gln Pro Arg Glu Ala Gln Tyr Asn Ser Thr Phe Arg 
65                  70                  75                  80  


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Arg Gly Lys 
                85                  90                  95      


Glu Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            100                 105                 110         


Arg Thr Ile Ser Lys Pro Lys Gly Arg Ala Gln Thr Pro Gln Val Tyr 
        115                 120                 125             


Thr Ile Pro Pro Pro Arg Glu Gln Met Ser Lys Lys Lys Val Ser Leu 
    130                 135                 140                 


Thr Cys Leu Val Thr Asn Phe Phe Ser Glu Ala Ile Ser Val Glu Trp 
145                 150                 155                 160 


Glu Arg Asn Gly Glu Leu Glu Gln Asp Tyr Lys Asn Thr Pro Pro Ile 
                165                 170                 175     


Leu Asp Ser Asp Gly Thr Tyr Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            180                 185                 190         


Thr Asp Ser Trp Leu Gln Gly Glu Ile Phe Thr Cys Ser Val Val His 
        195                 200                 205             


Glu Ala Leu His Asn His His Thr Gln Lys Asn Leu Ser Arg Ser Pro 
    210                 215                 220                 


Glu Leu Glu Leu Asn Glu Thr Cys Ala Glu Ala Gln Asp Gly Glu Leu 
225                 230                 235                 240 


Asp Gly Leu Trp Thr Thr Ile Thr Ile Phe Ile Ser Leu Phe Leu Leu 
                245                 250                 255     


Ser Val Cys Tyr Ser Ala Ser Val Thr Leu Phe Lys Val Lys Trp Ile 
            260                 265                 270         


Phe Ser Ser Val Val Gln Val Lys Gln Thr Ala Ile Pro Asp Tyr Arg 
        275                 280                 285             


Asn Met Ile Gly Gln Gly Ala 
    290                 295 


<210>  10
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  11
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210>  12
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  13
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  14
<211>  437
<212>  PRT
<213>  Art Seq CD80-Fc fusion protein

<400>  14

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    210                 215                 220                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
225                 230                 235                 240 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                245                 250                 255     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            260                 265                 270         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        275                 280                 285             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    290                 295                 300                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
305                 310                 315                 320 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                325                 330                 335     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
            340                 345                 350         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        355                 360                 365             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    370                 375                 380                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
385                 390                 395                 400 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                405                 410                 415     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            420                 425                 430         


Leu Ser Pro Gly Lys 
        435         


<210>  15
<211>  306
<212>  PRT
<213>  Mus musculus

<400>  15

Met Ala Cys Asn Cys Gln Leu Met Gln Asp Thr Pro Leu Leu Lys Phe 
1               5                   10                  15      


Pro Cys Pro Arg Leu Ile Leu Leu Phe Val Leu Leu Ile Arg Leu Ser 
            20                  25                  30          


Gln Val Ser Ser Asp Val Asp Glu Gln Leu Ser Lys Ser Val Lys Asp 
        35                  40                  45              


Lys Val Leu Leu Pro Cys Arg Tyr Asn Ser Pro His Glu Asp Glu Ser 
    50                  55                  60                  


Glu Asp Arg Ile Tyr Trp Gln Lys His Asp Lys Val Val Leu Ser Val 
65                  70                  75                  80  


Ile Ala Gly Lys Leu Lys Val Trp Pro Glu Tyr Lys Asn Arg Thr Leu 
                85                  90                  95      


Tyr Asp Asn Thr Thr Tyr Ser Leu Ile Ile Leu Gly Leu Val Leu Ser 
            100                 105                 110         


Asp Arg Gly Thr Tyr Ser Cys Val Val Gln Lys Lys Glu Arg Gly Thr 
        115                 120                 125             


Tyr Glu Val Lys His Leu Ala Leu Val Lys Leu Ser Ile Lys Ala Asp 
    130                 135                 140                 


Phe Ser Thr Pro Asn Ile Thr Glu Ser Gly Asn Pro Ser Ala Asp Thr 
145                 150                 155                 160 


Lys Arg Ile Thr Cys Phe Ala Ser Gly Gly Phe Pro Lys Pro Arg Phe 
                165                 170                 175     


Ser Trp Leu Glu Asn Gly Arg Glu Leu Pro Gly Ile Asn Thr Thr Ile 
            180                 185                 190         


Ser Gln Asp Pro Glu Ser Glu Leu Tyr Thr Ile Ser Ser Gln Leu Asp 
        195                 200                 205             


Phe Asn Thr Thr Arg Asn His Thr Ile Lys Cys Leu Ile Lys Tyr Gly 
    210                 215                 220                 


Asp Ala His Val Ser Glu Asp Phe Thr Trp Glu Lys Pro Pro Glu Asp 
225                 230                 235                 240 


Pro Pro Asp Ser Lys Asn Thr Leu Val Leu Phe Gly Ala Gly Phe Gly 
                245                 250                 255     


Ala Val Ile Thr Val Val Val Ile Val Val Ile Ile Lys Cys Phe Cys 
            260                 265                 270         


Lys His Arg Ser Cys Phe Arg Arg Asn Glu Ala Ser Arg Glu Thr Asn 
        275                 280                 285             


Asn Ser Leu Thr Phe Gly Pro Glu Glu Ala Leu Ala Glu Gln Thr Val 
    290                 295                 300                 


Phe Leu 
305     


<210>  16
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S156I-f

<400>  16
ccatcaacac aaccgtgatc caagaccccg aaacag                                 36


<210>  17
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S156I-r

<400>  17
ctgtttcggg gtcttggatc acggttgtgt tgatgg                                 36


<210>  18
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis A165S-f

<400>  18
ccgaaacaga gctctacagc gtgagtagta agctgg                                 36


<210>  19
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis A165S-r

<400>  19
ccagcttact actcacgctg tagagctctg tttcgg                                 36


<210>  20
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S131A-f

<400>  20
atcatctgca gtaccgctgg tgggttccct g                                      31


<210>  21
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S131A-r

<400>  21
cagggaaccc accagcggta ctgcagatga t                                      31


<210>  22
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S156F-f

<400>  22
catcaacaca accgtgttcc aagaccccga aacagagctc tac                         43


<210>  23
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S156F-r

<400>  23
gtttcggggt cttggaacac ggttgtgttg atggcgttga g                           41


<210>  24
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S156R-f

<400>  24
catcaacaca accgtgaggc aagaccccga aacagagctc tac                         43


<210>  25
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S156R-r

<400>  25
gtttcggggt cttgcctcac ggttgtgttg atggcgttga g                           41


<210>  26
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S156E-f

<400>  26
catcaacaca accgtggagc aagaccccga aacagagctc tac                         43


<210>  27
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S156E-r

<400>  27
gtttcggggt cttgctccac ggttgtgttg atggcgttga g                           41


<210>  28
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S156D-f

<400>  28
catcaacaca accgtggacc aagaccccga aacagagctc tac                         43


<210>  29
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S156D-r

<400>  29
gtttcggggt cttggtccac ggttgtgttg atggcgttga g                           41


<210>  30
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S156Q-f

<400>  30
catcaacaca accgtgcagc aagaccccga aacagagctc tac                         43


<210>  31
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S156Q-r

<400>  31
gtttcggggt cttgctgcac ggttgtgttg atggcgttga g                           41


<210>  32
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S131V-f

<400>  32
catctgcagt accgtgggtg ggttccctga gccccatctc                             40


<210>  33
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S131V-r

<400>  33
cagggaaccc acccacggta ctgcagatga ttctcctg                               38


<210>  34
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S131I-f

<400>  34
catctgcagt accatcggtg ggttccctga gccccatctc                             40


<210>  35
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S131I-r

<400>  35
cagggaaccc accgatggta ctgcagatga ttctcctg                               38


<210>  36
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S131F-f

<400>  36
catctgcagt accttcggtg ggttccctga gccccatctc                             40


<210>  37
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S131F-r

<400>  37
cagggaaccc accgaaggta ctgcagatga ttctcctg                               38


<210>  38
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S131R-f

<400>  38
catctgcagt accaggggtg ggttccctga gccccatctc                             40


<210>  39
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S131R-r

<400>  39
cagggaaccc acccctggta ctgcagatga ttctcctg                               38


<210>  40
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S131E-f

<400>  40
catctgcagt accgagggtg ggttccctga gccccatctc                             40


<210>  41
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S131E-r

<400>  41
cagggaaccc accctcggta ctgcagatga ttctcctg                               38


<210>  42
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S131D-f

<400>  42
catctgcagt accgacggtg ggttccctga gccccatctc                             40


<210>  43
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S131D-r

<400>  43
cagggaaccc accgtcggta ctgcagatga ttctcctg                               38


<210>  44
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S131Q-f

<400>  44
catctgcagt acccagggtg ggttccctga gccccatctc                             40


<210>  45
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S131Q-r

<400>  45
cagggaaccc accctgggta ctgcagatga ttctcctg                               38


<210>  46
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis A165V-f

<400>  46
gaaacagagc tctacgtggt gagtagtaag ctggacttta ac                          42


<210>  47
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis A165V-r

<400>  47
cttactactc accacgtaga gctctgtttc ggggtcttg                              39


<210>  48
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis A165I-f

<400>  48
gaaacagagc tctacatcgt gagtagtaag ctggacttta ac                          42


<210>  49
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis A165I-r

<400>  49
cttactactc acgatgtaga gctctgtttc ggggtcttg                              39


<210>  50
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis A165F-f

<400>  50
gaaacagagc tctacttcgt gagtagtaag ctggacttta ac                          42


<210>  51
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis A165F-r

<400>  51
cttactactc acgaagtaga gctctgtttc ggggtcttg                              39


<210>  52
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis A165R-f

<400>  52
gaaacagagc tctacagggt gagtagtaag ctggacttta ac                          42


<210>  53
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis A165R-r

<400>  53
cttactactc accctgtaga gctctgtttc ggggtcttg                              39


<210>  54
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis A165E-f

<400>  54
gaaacagagc tctacgaggt gagtagtaag ctggacttta ac                          42


<210>  55
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis A165E-r

<400>  55
cttactactc acctcgtaga gctctgtttc ggggtcttg                              39


<210>  56
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis A165D-f

<400>  56
gaaacagagc tctacgacgt gagtagtaag ctggacttta ac                          42


<210>  57
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis A165D-r

<400>  57
cttactactc acgtcgtaga gctctgtttc ggggtcttg                              39


<210>  58
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis A165Q-f

<400>  58
gaaacagagc tctaccaggt gagtagtaag ctggacttta ac                          42


<210>  59
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis A165Q-r

<400>  59
cttactactc acctggtaga gctctgtttc ggggtcttg                              39


<210>  60
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis T130A-f

<400>  60
caggagaatc atctgcagtg catctggtgg gttccctgag                             40


<210>  61
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis T130A-r

<400>  61
ctcagggaac ccaccagatg cactgcagat gattctcctg                             40


<210>  62
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S131V-f

<400>  62
gagaatcatc tgcagtaccg ttggtgggtt ccctgagcc                              39


<210>  63
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S131V-r

<400>  63
ggctcaggga acccaccaac ggtactgcag atgattctc                              39


<210>  64
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis L139V-f

<400>  64
gttccctgag ccccatgtta gctggctgga gaacg                                  35


<210>  65
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis L139V-r

<400>  65
cgttctccag ccagctaaca tggggctcag ggaac                                  35


<210>  66
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis V155A-f

<400>  66
caacgccatc aacacaaccg catcccaaga ccccgaaaca g                           41


<210>  67
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis V155A-r

<400>  67
ctgtttcggg gtcttgggat gcggttgtgt tgatggcgtt g                           41


<210>  68
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis V155I-f

<400>  68
caacgccatc aacacaacca tctcccaaga ccccgaaaca g                           41


<210>  69
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis V155I-r

<400>  69
ctgtttcggg gtcttgggag atggttgtgt tgatggcgtt g                           41


<210>  70
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis V155T-f

<400>  70
caacgccatc aacacaacca cctcccaaga ccccgaaaca g                           41


<210>  71
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis V155T-r

<400>  71
ctgtttcggg gtcttgggag gtggttgtgt tgatggcgtt g                           41


<210>  72
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S156A-f

<400>  72
gccatcaaca caaccgtggc acaagacccc gaaacagag                              39


<210>  73
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S156A-r

<400>  73
ctctgtttcg gggtcttgtg ccacggttgt gttgatggc                              39


<210>  74
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis V166A-f

<400>  74
cgaaacagag ctctacgccg caagtagtaa gctggacttt aac                         43


<210>  75
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis V166A-r

<400>  75
gttaaagtcc agcttactac ttgcggcgta gagctctgtt tcg                         43


<210>  76
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis V166L-f

<400>  76
ccgaaacaga gctctacgcc ctcagtagta agctggactt taac                        44


<210>  77
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis V166L-r

<400>  77
gttaaagtcc agcttactac tgagggcgta gagctctgtt tcgg                        44


<210>  78
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis V166T-f

<400>  78
ccgaaacaga gctctacgcc accagtagta agctggactt taac                        44


<210>  79
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis V166T-r

<400>  79
gttaaagtcc agcttactac tggtggcgta gagctctgtt tcgg                        44


<210>  80
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S155A/S156A-f

<400>  80
caacgccatc aacacaaccg cagcacaaga ccccgaaaca gagc                        44


<210>  81
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis S155A/S156A-r

<400>  81
gctctgtttc ggggtcttgt gctgcggttg tgttgatggc gttg                        44


<210>  82
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis V155I/S156A-f

<400>  82
caacgccatc aacacaacca tcgcccaaga ccccgaaaca gagc                        44


<210>  83
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis V155I/S156A-r

<400>  83
gctctgtttc ggggtcttgg gcgatggttg tgttgatggc gttg                        44


<210>  84
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis V155T/S156A-f

<400>  84
caacgccatc aacacaacca ccgcccaaga ccccgaaaca gag                         43


<210>  85
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer for site-directed mutagenesis V155T/S156A-r

<400>  85
ctctgtttcg gggtcttggg cggtggttgt gttgatggcg ttg                         43


