                         SEQUENCE LISTING

<110>  THE CHILDREN'S HOSPITAL OF PHILADELPHIA
 
<120>  CRISPR/CAS9 GENE EDITING OF ATXN2 FOR THE TREATMENT OF 
       SPINOCEREBALLAR ATAXIA TYPE 2

<130>  CHOP.P0027WO

<140>  not yet known
<141>  2020-04-24

<150>  US 62/839,336
<151>  2019-04-26

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligo

<400>  1
gccaatgtcc gcaagcccgg                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligo

<400>  2
ccgccctccg atgcgctcag                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligo

<400>  3
gcgagactcg gtggccaccg                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligo

<400>  4
accaaaacag tctgaggcgg                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligo

<400>  5
gtcgccgcga ccaccgagga                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligo

<400>  6
ggtcgccgcg accaccgagg                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligo

<400>  7
gtgacccgcc gggctacccg                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligo

<400>  8
gcccaccccg ggtagcccgg                                                   20


<210>  9
<211>  1307
<212>  PRT
<213>  Acidaminococcus

<400>  9

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  10
<211>  1228
<212>  PRT
<213>  Lachnospiraceae

<400>  10

Ala Ala Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile 
            20                  25                  30          


Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr 
        35                  40                  45              


Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn 
    50                  55                  60                  


Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser 
65                  70                  75                  80  


Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu 
                85                  90                  95      


Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly 
            100                 105                 110         


Ala Ala Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile 
        115                 120                 125             


Leu Pro Glu Ala Ala Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser 
    130                 135                 140                 


Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu 
145                 150                 155                 160 


Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys 
                165                 170                 175     


Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu 
            180                 185                 190         


Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu 
        195                 200                 205             


Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu 
    210                 215                 220                 


Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala 
225                 230                 235                 240 


Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu 
                245                 250                 255     


Asn Glu Tyr Ile Asn Leu Tyr Asn Ala Lys Thr Lys Gln Ala Leu Pro 
            260                 265                 270         


Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu 
        275                 280                 285             


Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val 
    290                 295                 300                 


Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys 
305                 310                 315                 320 


Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly 
                325                 330                 335     


Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile 
            340                 345                 350         


Phe Gly Glu Trp Asn Leu Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp 
        355                 360                 365             


Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp 
    370                 375                 380                 


Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln 
385                 390                 395                 400 


Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys 
                405                 410                 415     


Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser 
            420                 425                 430         


Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys 
        435                 440                 445             


Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val 
    450                 455                 460                 


Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu 
465                 470                 475                 480 


Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp 
                485                 490                 495     


Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val 
            500                 505                 510         


Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn 
        515                 520                 525             


Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg 
    530                 535                 540                 


Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp 
545                 550                 555                 560 


Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn 
                565                 570                 575     


Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys 
            580                 585                 590         


Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn 
        595                 600                 605             


Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys 
    610                 615                 620                 


Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe 
625                 630                 635                 640 


Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe 
                645                 650                 655     


Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg 
            660                 665                 670         


Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys 
        675                 680                 685             


Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln 
    690                 695                 700                 


Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu 
705                 710                 715                 720 


His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln 
                725                 730                 735     


Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu 
            740                 745                 750         


Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn 
        755                 760                 765             


Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val 
    770                 775                 780                 


Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro 
785                 790                 795                 800 


Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu 
                805                 810                 815     


Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile 
            820                 825                 830         


Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys 
        835                 840                 845             


Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe 
    850                 855                 860                 


Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys 
865                 870                 875                 880 


Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn 
                885                 890                 895     


Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile 
            900                 905                 910         


Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu 
        915                 920                 925             


Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr 
    930                 935                 940                 


Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp 
945                 950                 955                 960 


Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln 
                965                 970                 975     


Ile Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly 
            980                 985                 990         


Phe Ile Phe Tyr Ile Pro Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser 
        995                 1000                 1005             


Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala 
    1010                 1015                 1020             


Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp Arg Ile  Met Tyr Val 
    1025                 1030                 1035             


Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu Asp Tyr  Lys Asn Phe 
    1040                 1045                 1050             


Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys Trp Lys  Leu Tyr Ser 
    1055                 1060                 1065             


Tyr Gly  Asn Arg Ile Arg Ile  Phe Ala Ala Ala Lys  Lys Asn Asn 
    1070                 1075                 1080             


Val Phe  Ala Trp Glu Glu Val  Cys Leu Thr Ser Ala  Tyr Lys Glu 
    1085                 1090                 1095             


Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln Gln Gly  Asp Ile Arg 
    1100                 1105                 1110             


Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala Phe Tyr  Ser Ser Phe 
    1115                 1120                 1125             


Met Ala  Leu Met Ser Leu Met  Leu Gln Met Arg Asn  Ser Ile Thr 
    1130                 1135                 1140             


Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser Pro Val  Lys Asn Ser 
    1145                 1150                 1155             


Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr Glu Ala  Gln Glu Asn 
    1160                 1165                 1170             


Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile 
    1175                 1180                 1185             


Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln Phe Lys  Lys Ala Glu 
    1190                 1195                 1200             


Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala Ile Ser  Asn Lys Glu 
    1205                 1210                 1215             


Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys 
    1220                 1225             


<210>  11
<211>  41
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Syntheic peptide

<400>  11

Arg Met Arg Lys Phe Lys Asn Lys Gly Lys Asp Thr Ala Glu Leu Arg 
1               5                   10                  15      


Arg Arg Arg Val Glu Val Ser Val Glu Leu Arg Lys Ala Lys Lys Asp 
            20                  25                  30          


Glu Gln Ile Leu Lys Arg Arg Asn Val 
        35                  40      


<210>  12
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Syntheic peptide

<400>  12

Val Ser Arg Lys Arg Pro Arg Pro 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Syntheic peptide

<400>  13

Pro Pro Lys Lys Ala Arg Glu Asp 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Syntheic peptide

<400>  14

Pro Gln Pro Lys Lys Lys Pro Leu 
1               5               


<210>  15
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Syntheic peptide

<400>  15

Ser Ala Leu Ile Lys Lys Lys Lys Lys Met Ala Pro 
1               5                   10          


<210>  16
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Syntheic peptide

<400>  16

Asp Arg Leu Arg Arg 
1               5   


<210>  17
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Syntheic peptide

<400>  17

Lys Gln Lys Lys Arg Lys 
1               5       


<210>  18
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Syntheic peptide

<400>  18

Arg Lys Leu Lys Lys Lys Ile Lys Lys Leu 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Syntheic peptide

<400>  19

Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg 
1               5                   10  


<210>  20
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Syntheic peptide

<400>  20

Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys 
1               5                   10                  15      


Lys Ser Lys Lys 
            20  


<210>  21
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Syntheic peptide

<400>  21

Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys 
1               5                   10                  15      


Lys 
    


<210>  22
<211>  1313
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Arg Ser Ala Ala Ala Ala Pro Arg Ser Pro Ala Val Ala Thr Glu 
1               5                   10                  15      


Ser Arg Arg Phe Ala Ala Ala Arg Trp Pro Gly Trp Arg Ser Leu Gln 
            20                  25                  30          


Arg Pro Ala Arg Arg Ser Gly Arg Gly Gly Gly Gly Ala Ala Pro Gly 
        35                  40                  45              


Pro Tyr Pro Ser Ala Ala Pro Pro Pro Pro Gly Pro Gly Pro Pro Pro 
    50                  55                  60                  


Ser Arg Gln Ser Ser Pro Pro Ser Ala Ser Asp Cys Phe Gly Ser Asn 
65                  70                  75                  80  


Gly Asn Gly Gly Gly Ala Phe Arg Pro Gly Ser Arg Arg Leu Leu Gly 
                85                  90                  95      


Leu Gly Gly Pro Pro Arg Pro Phe Val Val Leu Leu Leu Pro Leu Ala 
            100                 105                 110         


Ser Pro Gly Ala Pro Pro Ala Ala Pro Thr Arg Ala Ser Pro Leu Gly 
        115                 120                 125             


Ala Arg Ala Ser Pro Pro Arg Ser Gly Val Ser Leu Ala Arg Pro Ala 
    130                 135                 140                 


Pro Gly Cys Pro Arg Pro Ala Cys Glu Pro Val Tyr Gly Pro Leu Thr 
145                 150                 155                 160 


Met Ser Leu Lys Pro Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                165                 170                 175     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Ala 
            180                 185                 190         


Ala Ala Asn Val Arg Lys Pro Gly Gly Ser Gly Leu Leu Ala Ser Pro 
        195                 200                 205             


Ala Ala Ala Pro Ser Pro Ser Ser Ser Ser Val Ser Ser Ser Ser Ala 
    210                 215                 220                 


Thr Ala Pro Ser Ser Val Val Ala Ala Thr Ser Gly Gly Gly Arg Pro 
225                 230                 235                 240 


Gly Leu Gly Arg Gly Arg Asn Ser Asn Lys Gly Leu Pro Gln Ser Thr 
                245                 250                 255     


Ile Ser Phe Asp Gly Ile Tyr Ala Asn Met Arg Met Val His Ile Leu 
            260                 265                 270         


Thr Ser Val Val Gly Ser Lys Cys Glu Val Gln Val Lys Asn Gly Gly 
        275                 280                 285             


Ile Tyr Glu Gly Val Phe Lys Thr Tyr Ser Pro Lys Cys Asp Leu Val 
    290                 295                 300                 


Leu Asp Ala Ala His Glu Lys Ser Thr Glu Ser Ser Ser Gly Pro Lys 
305                 310                 315                 320 


Arg Glu Glu Ile Met Glu Ser Ile Leu Phe Lys Cys Ser Asp Phe Val 
                325                 330                 335     


Val Val Gln Phe Lys Asp Met Asp Ser Ser Tyr Ala Lys Arg Asp Ala 
            340                 345                 350         


Phe Thr Asp Ser Ala Ile Ser Ala Lys Val Asn Gly Glu His Lys Glu 
        355                 360                 365             


Lys Asp Leu Glu Pro Trp Asp Ala Gly Glu Leu Thr Ala Asn Glu Glu 
    370                 375                 380                 


Leu Glu Ala Leu Glu Asn Asp Val Ser Asn Gly Trp Asp Pro Asn Asp 
385                 390                 395                 400 


Met Phe Arg Tyr Asn Glu Glu Asn Tyr Gly Val Val Ser Thr Tyr Asp 
                405                 410                 415     


Ser Ser Leu Ser Ser Tyr Thr Val Pro Leu Glu Arg Asp Asn Ser Glu 
            420                 425                 430         


Glu Phe Leu Lys Arg Glu Ala Arg Ala Asn Gln Leu Ala Glu Glu Ile 
        435                 440                 445             


Glu Ser Ser Ala Gln Tyr Lys Ala Arg Val Ala Leu Glu Asn Asp Asp 
    450                 455                 460                 


Arg Ser Glu Glu Glu Lys Tyr Thr Ala Val Gln Arg Asn Ser Ser Glu 
465                 470                 475                 480 


Arg Glu Gly His Ser Ile Asn Thr Arg Glu Asn Lys Tyr Ile Pro Pro 
                485                 490                 495     


Gly Gln Arg Asn Arg Glu Val Ile Ser Trp Gly Ser Gly Arg Gln Asn 
            500                 505                 510         


Ser Pro Arg Met Gly Gln Pro Gly Ser Gly Ser Met Pro Ser Arg Ser 
        515                 520                 525             


Thr Ser His Thr Ser Asp Phe Asn Pro Asn Ser Gly Ser Asp Gln Arg 
    530                 535                 540                 


Val Val Asn Gly Gly Val Pro Trp Pro Ser Pro Cys Pro Ser Pro Ser 
545                 550                 555                 560 


Ser Arg Pro Pro Ser Arg Tyr Gln Ser Gly Pro Asn Ser Leu Pro Pro 
                565                 570                 575     


Arg Ala Ala Thr Pro Thr Arg Pro Pro Ser Arg Pro Pro Ser Arg Pro 
            580                 585                 590         


Ser Arg Pro Pro Ser His Pro Ser Ala His Gly Ser Pro Ala Pro Val 
        595                 600                 605             


Ser Thr Met Pro Lys Arg Met Ser Ser Glu Gly Pro Pro Arg Met Ser 
    610                 615                 620                 


Pro Lys Ala Gln Arg His Pro Arg Asn His Arg Val Ser Ala Gly Arg 
625                 630                 635                 640 


Gly Ser Ile Ser Ser Gly Leu Glu Phe Val Ser His Asn Pro Pro Ser 
                645                 650                 655     


Glu Ala Ala Thr Pro Pro Val Ala Arg Thr Ser Pro Ser Gly Gly Thr 
            660                 665                 670         


Trp Ser Ser Val Val Ser Gly Val Pro Arg Leu Ser Pro Lys Thr His 
        675                 680                 685             


Arg Pro Arg Ser Pro Arg Gln Asn Ser Ile Gly Asn Thr Pro Ser Gly 
    690                 695                 700                 


Pro Val Leu Ala Ser Pro Gln Ala Gly Ile Ile Pro Thr Glu Ala Val 
705                 710                 715                 720 


Ala Met Pro Ile Pro Ala Ala Ser Pro Thr Pro Ala Ser Pro Ala Ser 
                725                 730                 735     


Asn Arg Ala Val Thr Pro Ser Ser Glu Ala Lys Asp Ser Arg Leu Gln 
            740                 745                 750         


Asp Gln Arg Gln Asn Ser Pro Ala Gly Asn Lys Glu Asn Ile Lys Pro 
        755                 760                 765             


Asn Glu Thr Ser Pro Ser Phe Ser Lys Ala Glu Asn Lys Gly Ile Ser 
    770                 775                 780                 


Pro Val Val Ser Glu His Arg Lys Gln Ile Asp Asp Leu Lys Lys Phe 
785                 790                 795                 800 


Lys Asn Asp Phe Arg Leu Gln Pro Ser Ser Thr Ser Glu Ser Met Asp 
                805                 810                 815     


Gln Leu Leu Asn Lys Asn Arg Glu Gly Glu Lys Ser Arg Asp Leu Ile 
            820                 825                 830         


Lys Asp Lys Ile Glu Pro Ser Ala Lys Asp Ser Phe Ile Glu Asn Ser 
        835                 840                 845             


Ser Ser Asn Cys Thr Ser Gly Ser Ser Lys Pro Asn Ser Pro Ser Ile 
    850                 855                 860                 


Ser Pro Ser Ile Leu Ser Asn Thr Glu His Lys Arg Gly Pro Glu Val 
865                 870                 875                 880 


Thr Ser Gln Gly Val Gln Thr Ser Ser Pro Ala Cys Lys Gln Glu Lys 
                885                 890                 895     


Asp Asp Lys Glu Glu Lys Lys Asp Ala Ala Glu Gln Val Arg Lys Ser 
            900                 905                 910         


Thr Leu Asn Pro Asn Ala Lys Glu Phe Asn Pro Arg Ser Phe Ser Gln 
        915                 920                 925             


Pro Lys Pro Ser Thr Thr Pro Thr Ser Pro Arg Pro Gln Ala Gln Pro 
    930                 935                 940                 


Ser Pro Ser Met Val Gly His Gln Gln Pro Thr Pro Val Tyr Thr Gln 
945                 950                 955                 960 


Pro Val Cys Phe Ala Pro Asn Met Met Tyr Pro Val Pro Val Ser Pro 
                965                 970                 975     


Gly Val Gln Pro Leu Tyr Pro Ile Pro Met Thr Pro Met Pro Val Asn 
            980                 985                 990         


Gln Ala Lys Thr Tyr Arg Ala Val  Pro Asn Met Pro Gln  Gln Arg Gln 
        995                 1000                 1005             


Asp Gln  His His Gln Ser Ala  Met Met His Pro Ala  Ser Ala Ala 
    1010                 1015                 1020             


Gly Pro  Pro Ile Ala Ala Thr  Pro Pro Ala Tyr Ser  Thr Gln Tyr 
    1025                 1030                 1035             


Val Ala  Tyr Ser Pro Gln Gln  Phe Pro Asn Gln Pro  Leu Val Gln 
    1040                 1045                 1050             


His Val  Pro His Tyr Gln Ser  Gln His Pro His Val  Tyr Ser Pro 
    1055                 1060                 1065             


Val Ile  Gln Gly Asn Ala Arg  Met Met Ala Pro Pro  Thr His Ala 
    1070                 1075                 1080             


Gln Pro  Gly Leu Val Ser Ser  Ser Ala Thr Gln Tyr  Gly Ala His 
    1085                 1090                 1095             


Glu Gln  Thr His Ala Met Tyr  Ala Cys Pro Lys Leu  Pro Tyr Asn 
    1100                 1105                 1110             


Lys Glu  Thr Ser Pro Ser Phe  Tyr Phe Ala Ile Ser  Thr Gly Ser 
    1115                 1120                 1125             


Leu Ala  Gln Gln Tyr Ala His  Pro Asn Ala Thr Leu  His Pro His 
    1130                 1135                 1140             


Thr Pro  His Pro Gln Pro Ser  Ala Thr Pro Thr Gly  Gln Gln Gln 
    1145                 1150                 1155             


Ser Gln  His Gly Gly Ser His  Pro Ala Pro Ser Pro  Val Gln His 
    1160                 1165                 1170             


His Gln  His Gln Ala Ala Gln  Ala Leu His Leu Ala  Ser Pro Gln 
    1175                 1180                 1185             


Gln Gln  Ser Ala Ile Tyr His  Ala Gly Leu Ala Pro  Thr Pro Pro 
    1190                 1195                 1200             


Ser Met  Thr Pro Ala Ser Asn  Thr Gln Ser Pro Gln  Asn Ser Phe 
    1205                 1210                 1215             


Pro Ala  Ala Gln Gln Thr Val  Phe Thr Ile His Pro  Ser His Val 
    1220                 1225                 1230             


Gln Pro  Ala Tyr Thr Asn Pro  Pro His Met Ala His  Val Pro Gln 
    1235                 1240                 1245             


Ala His  Val Gln Ser Gly Met  Val Pro Ser His Pro  Thr Ala His 
    1250                 1255                 1260             


Ala Pro  Met Met Leu Met Thr  Thr Gln Pro Pro Gly  Gly Pro Gln 
    1265                 1270                 1275             


Ala Ala  Leu Ala Gln Ser Ala  Leu Gln Pro Ile Pro  Val Ser Thr 
    1280                 1285                 1290             


Thr Ala  His Phe Pro Tyr Met  Thr His Pro Ser Val  Gln Ala His 
    1295                 1300                 1305             


His Gln  Gln Gln Leu 
    1310             


<210>  23
<211>  4712
<212>  DNA
<213>  Homo sapiens

<400>  23
acccccgaga aagcaaccca gcgcgccgcc cgctcctcac gtgtccctcc cggccccggg       60

gccacctcac gttctgcttc cgtctgaccc ctccgacttc cggtaaagag tccctatccg      120

cacctccgct cccacccggc gcctcggcgc gcccgccctc cgatgcgctc agcggccgca      180

gctcctcgga gtcccgcggt ggccaccgag tctcgccgct tcgccgcagc caggtggccc      240

gggtggcgct cgctccagcg gccggcgcgg cggagcgggc ggggcggcgg tggcgcggcc      300

ccgggaccgt atccctccgc cgcccctccc ccgcccggcc ccggcccccc tccctcccgg      360

cagagctcgc ctccctccgc ctcagactgt tttggtagca acggcaacgg cggcggcgcg      420

tttcggcccg gctcccggcg gctccttggt ctcggcgggc ctccccgccc cttcgtcgtc      480

ctccttctcc ccctcgccag cccgggcgcc cctccggccg cgccaacccg cgcctccccg      540

ctcggcgccc gcgcgtcccc gccgcgttcc ggcgtctcct tggcgcgccc ggctcccggc      600

tgtccccgcc cggcgtgcga gccggtgtat gggcccctca ccatgtcgct gaagccccag      660

cagcagcagc agcagcagca gcagcagcag cagcagcaac agcagcagca gcagcagcag      720

cagcagccgc cgcccgcggc tgccaatgtc cgcaagcccg gcggcagcgg ccttctagcg      780

tcgcccgccg ccgcgccttc gccgtcctcg tcctcggtct cctcgtcctc ggccacggct      840

ccctcctcgg tggtcgcggc gacctccggc ggcgggaggc ccggcctggg cagaggtcga      900

aacagtaaca aaggactgcc tcagtctacg atttcttttg atggaatcta tgcaaatatg      960

aggatggttc atatacttac atcagttgtt ggctccaaat gtgaagtaca agtgaaaaat     1020

ggaggtatat atgaaggagt ttttaaaact tacagtccga agtgtgattt ggtacttgat     1080

gccgcacatg agaaaagtac agaatccagt tcggggccga aacgtgaaga aataatggag     1140

agtattttgt tcaaatgttc agactttgtt gtggtacagt ttaaagatat ggactccagt     1200

tatgcaaaaa gagatgcttt tactgactct gctatcagtg ctaaagtgaa tggcgaacac     1260

aaagagaagg acctggagcc ctgggatgca ggtgaactca cagccaatga ggaacttgag     1320

gctttggaaa atgacgtatc taatggatgg gatcccaatg atatgtttcg atataatgaa     1380

gaaaattatg gtgtagtgtc tacgtatgat agcagtttat cttcgtatac agtgccctta     1440

gaaagagata actcagaaga atttttaaaa cgggaagcaa gggcaaacca gttagcagaa     1500

gaaattgagt caagtgccca gtacaaagct cgagtggccc tggaaaatga tgataggagt     1560

gaggaagaaa aatacacagc agttcagaga aattccagtg aacgtgaggg gcacagcata     1620

aacactaggg aaaataaata tattcctcct ggacaaagaa atagagaagt catatcctgg     1680

ggaagtggga gacagaattc accgcgtatg ggccagcctg gatcgggctc catgccatca     1740

agatccactt ctcacacttc agatttcaac ccgaattctg gttcagacca aagagtagtt     1800

aatggaggtg ttccctggcc atcgccttgc ccatctcctt cctctcgccc accttctcgc     1860

taccagtcag gtcccaactc tcttccacct cgggcagcca cccctacacg gccgccctcc     1920

aggcccccct cgcggccatc cagacccccg tctcacccct ctgctcatgg ttctccagct     1980

cctgtctcta ctatgcctaa acgcatgtct tcagaagggc ctccaaggat gtccccaaag     2040

gcccagcgac atcctcgaaa tcacagagtt tctgctggga ggggttccat atccagtggc     2100

ctagaatttg tatcccacaa cccacccagt gaagcagcta ctcctccagt agcaaggacc     2160

agtccctcgg ggggaacgtg gtcatcagtg gtcagtgggg ttccaagatt atcccctaaa     2220

actcatagac ccaggtctcc cagacagaac agtattggaa atacccccag tgggccagtt     2280

cttgcttctc cccaagctgg tattattcca actgaagctg ttgccatgcc tattccagct     2340

gcatctccta cgcctgctag tcctgcatcg aacagagctg ttaccccttc tagtgaggct     2400

aaagattcca ggcttcaaga tcagaggcag aactctcctg cagggaataa agaaaatatt     2460

aaacccaatg aaacatcacc tagcttctca aaagctgaaa acaaaggtat atcaccagtt     2520

gtttctgaac atagaaaaca gattgatgat ttaaagaaat ttaagaatga ttttaggtta     2580

cagccaagtt ctacttctga atctatggat caactactaa acaaaaatag agagggagaa     2640

aaatcaagag atttgatcaa agacaaaatt gaaccaagtg ctaaggattc tttcattgaa     2700

aatagcagca gcaactgtac cagtggcagc agcaagccga atagccccag catttcccct     2760

tcaatactta gtaacacgga gcacaagagg ggacctgagg tcacttccca aggggttcag     2820

acttccagcc cagcatgtaa acaagagaaa gacgataagg aagagaagaa agacgcagct     2880

gagcaagtta ggaaatcaac attgaatccc aatgcaaagg agttcaaccc acgttccttc     2940

tctcagccaa agccttctac taccccaact tcacctcggc ctcaagcaca acctagccca     3000

tctatggtgg gtcatcaaca gccaactcca gtttatactc agcctgtttg ttttgcacca     3060

aatatgatgt atccagtccc agtgagccca ggcgtgcaac ctttataccc aatacctatg     3120

acgcccatgc cagtgaatca agccaagaca tatagagcag taccaaatat gccccaacag     3180

cggcaagacc agcatcatca gagtgccatg atgcacccag cgtcagcagc gggcccaccg     3240

attgcagcca ccccaccagc ttactccacg caatatgttg cctacagtcc tcagcagttc     3300

ccaaatcagc cccttgttca gcatgtgcca cattatcagt ctcagcatcc tcatgtctat     3360

agtcctgtaa tacagggtaa tgctagaatg atggcaccac caacacacgc ccagcctggt     3420

ttagtatctt cttcagcaac tcagtacggg gctcatgagc agacgcatgc gatgtatgca     3480

tgtcccaaat taccatacaa caaggagaca agcccttctt tctactttgc catttccacg     3540

ggctcccttg ctcagcagta tgcgcaccct aacgctaccc tgcacccaca tactccacac     3600

cctcagcctt cagctacccc cactggacag cagcaaagcc aacatggtgg aagtcatcct     3660

gcacccagtc ctgttcagca ccatcagcac caggccgccc aggctctcca tctggccagt     3720

ccacagcagc agtcagccat ttaccacgcg gggcttgcgc caactccacc ctccatgaca     3780

cctgcctcca acacgcagtc gccacagaat agtttcccag cagcacaaca gactgtcttt     3840

acgatccatc cttctcacgt tcagccggcg tataccaacc caccccacat ggcccacgta     3900

cctcaggctc atgtacagtc aggaatggtt ccttctcatc caactgccca tgcgccaatg     3960

atgctaatga cgacacagcc acccggcggt ccccaggccg ccctcgctca aagtgcacta     4020

cagcccattc cagtctcgac aacagcgcat ttcccctata tgacgcaccc ttcagtacaa     4080

gcccaccacc aacagcagtt gtaaggctgc cctggaggaa ccgaaaggcc aaattccctc     4140

ctcccttcta ctgcttctac caactggaag cacagaaaac tagaatttca tttattttgt     4200

ttttaaaata tatatgttga tttcttgtaa catccaatag gaatgctaac agttcacttg     4260

cagtggaaga tacttggacc gagtagaggc atttaggaac ttgggggcta ttccataatt     4320

ccatatgctg tttcagagtc ccgcaggtac cccagctctg cttgccgaaa ctggaagtta     4380

tttatttttt aataaccctt gaaagtcatg aacacatcag ctagcaaaag aagtaacaag     4440

agtgattctt gctgctatta ctgctaaaaa aaaaaaaaaa aaaaaatcaa gacttggaac     4500

gcccttttac taaacttgac aaagtttcag taaattctta ccgtcaaact gacggattat     4560

tatttataaa tcaagtttga tgaggtgatc actgtctaca gtggttcaac ttttaagtta     4620

agggaaaaac ttttactttg tagataatat aaaataaaaa cttaaaaaaa atttaaaaaa     4680

taaaaaaagt tttaaaaact gaaaaaaaaa aa                                   4712


<210>  24
<211>  1073
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Arg Met Val His Ile Leu Thr Ser Val Val Gly Ser Lys Cys Glu 
1               5                   10                  15      


Val Gln Val Lys Asn Gly Gly Ile Tyr Glu Gly Val Phe Lys Thr Tyr 
            20                  25                  30          


Ser Pro Lys Cys Asp Leu Val Leu Asp Ala Ala His Glu Lys Ser Thr 
        35                  40                  45              


Glu Ser Ser Ser Gly Pro Lys Arg Glu Glu Ile Met Glu Ser Ile Leu 
    50                  55                  60                  


Phe Lys Cys Ser Asp Phe Val Val Val Gln Phe Lys Asp Met Asp Ser 
65                  70                  75                  80  


Ser Tyr Ala Lys Arg Asp Ala Phe Thr Asp Ser Ala Ile Ser Ala Lys 
                85                  90                  95      


Val Asn Gly Glu His Lys Glu Lys Asp Leu Glu Pro Trp Asp Ala Gly 
            100                 105                 110         


Glu Leu Thr Ala Asn Glu Glu Leu Glu Ala Leu Glu Asn Asp Val Ser 
        115                 120                 125             


Asn Gly Trp Asp Pro Asn Asp Met Phe Arg Tyr Asn Glu Glu Asn Tyr 
    130                 135                 140                 


Gly Val Val Ser Thr Tyr Asp Ser Ser Leu Ser Ser Tyr Thr Val Pro 
145                 150                 155                 160 


Leu Glu Arg Asp Asn Ser Glu Glu Phe Leu Lys Arg Glu Ala Arg Ala 
                165                 170                 175     


Asn Gln Leu Ala Glu Glu Ile Glu Ser Ser Ala Gln Tyr Lys Ala Arg 
            180                 185                 190         


Val Ala Leu Glu Asn Asp Asp Arg Ser Glu Glu Glu Lys Tyr Thr Ala 
        195                 200                 205             


Val Gln Arg Asn Ser Ser Glu Arg Glu Gly His Ser Ile Asn Thr Arg 
    210                 215                 220                 


Glu Asn Lys Tyr Ile Pro Pro Gly Gln Arg Asn Arg Glu Val Ile Ser 
225                 230                 235                 240 


Trp Gly Ser Gly Arg Gln Asn Ser Pro Arg Met Gly Gln Pro Gly Ser 
                245                 250                 255     


Gly Ser Met Pro Ser Arg Ser Thr Ser His Thr Ser Asp Phe Asn Pro 
            260                 265                 270         


Asn Ser Gly Ser Asp Gln Arg Val Val Asn Gly Gly Val Pro Trp Pro 
        275                 280                 285             


Ser Pro Cys Pro Ser Pro Ser Ser Arg Pro Pro Ser Arg Tyr Gln Ser 
    290                 295                 300                 


Gly Pro Asn Ser Leu Pro Pro Arg Ala Ala Thr Pro Thr Arg Pro Pro 
305                 310                 315                 320 


Ser Arg Pro Pro Ser Arg Pro Ser Arg Pro Pro Ser His Pro Ser Ala 
                325                 330                 335     


His Gly Ser Pro Ala Pro Val Ser Thr Met Pro Lys Arg Met Ser Ser 
            340                 345                 350         


Glu Gly Pro Pro Arg Met Ser Pro Lys Ala Gln Arg His Pro Arg Asn 
        355                 360                 365             


His Arg Val Ser Ala Gly Arg Gly Ser Ile Ser Ser Gly Leu Glu Phe 
    370                 375                 380                 


Val Ser His Asn Pro Pro Ser Glu Ala Ala Thr Pro Pro Val Ala Arg 
385                 390                 395                 400 


Thr Ser Pro Ser Gly Gly Thr Trp Ser Ser Val Val Ser Gly Val Pro 
                405                 410                 415     


Arg Leu Ser Pro Lys Thr His Arg Pro Arg Ser Pro Arg Gln Asn Ser 
            420                 425                 430         


Ile Gly Asn Thr Pro Ser Gly Pro Val Leu Ala Ser Pro Gln Ala Gly 
        435                 440                 445             


Ile Ile Pro Thr Glu Ala Val Ala Met Pro Ile Pro Ala Ala Ser Pro 
    450                 455                 460                 


Thr Pro Ala Ser Pro Ala Ser Asn Arg Ala Val Thr Pro Ser Ser Glu 
465                 470                 475                 480 


Ala Lys Asp Ser Arg Leu Gln Asp Gln Arg Gln Asn Ser Pro Ala Gly 
                485                 490                 495     


Asn Lys Glu Asn Ile Lys Pro Asn Glu Thr Ser Pro Ser Phe Ser Lys 
            500                 505                 510         


Ala Glu Asn Lys Gly Ile Ser Pro Val Val Ser Glu His Arg Lys Gln 
        515                 520                 525             


Ile Asp Asp Leu Lys Lys Phe Lys Asn Asp Phe Arg Leu Gln Pro Ser 
    530                 535                 540                 


Ser Thr Ser Glu Ser Met Asp Gln Leu Leu Asn Lys Asn Arg Glu Gly 
545                 550                 555                 560 


Glu Lys Ser Arg Asp Leu Ile Lys Asp Lys Ile Glu Pro Ser Ala Lys 
                565                 570                 575     


Asp Ser Phe Ile Glu Asn Ser Ser Ser Asn Cys Thr Ser Gly Ser Ser 
            580                 585                 590         


Lys Pro Asn Ser Pro Ser Ile Ser Pro Ser Ile Leu Ser Asn Thr Glu 
        595                 600                 605             


His Lys Arg Gly Pro Glu Val Thr Ser Gln Gly Val Gln Thr Ser Ser 
    610                 615                 620                 


Pro Ala Cys Lys Gln Glu Lys Asp Asp Lys Glu Glu Lys Lys Asp Ala 
625                 630                 635                 640 


Ala Glu Gln Val Arg Lys Ser Thr Leu Asn Pro Asn Ala Lys Glu Phe 
                645                 650                 655     


Asn Pro Arg Ser Phe Ser Gln Pro Lys Pro Ser Thr Thr Pro Thr Ser 
            660                 665                 670         


Pro Arg Pro Gln Ala Gln Pro Ser Pro Ser Met Val Gly His Gln Gln 
        675                 680                 685             


Pro Thr Pro Val Tyr Thr Gln Pro Val Cys Phe Ala Pro Asn Met Met 
    690                 695                 700                 


Tyr Pro Val Pro Val Ser Pro Gly Val Gln Pro Leu Tyr Pro Ile Pro 
705                 710                 715                 720 


Met Thr Pro Met Pro Val Asn Gln Ala Lys Thr Tyr Arg Ala Val Pro 
                725                 730                 735     


Asn Met Pro Gln Gln Arg Gln Asp Gln His His Gln Ser Ala Met Met 
            740                 745                 750         


His Pro Ala Ser Ala Ala Gly Pro Pro Ile Ala Ala Thr Pro Pro Ala 
        755                 760                 765             


Tyr Ser Thr Gln Tyr Val Ala Tyr Ser Pro Gln Gln Phe Pro Asn Gln 
    770                 775                 780                 


Pro Leu Val Gln His Val Pro His Tyr Gln Ser Gln His Pro His Val 
785                 790                 795                 800 


Tyr Ser Pro Val Ile Gln Gly Asn Ala Arg Met Met Ala Pro Pro Thr 
                805                 810                 815     


His Ala Gln Pro Gly Leu Val Ser Ser Ser Ala Thr Gln Tyr Gly Ala 
            820                 825                 830         


His Glu Gln Thr His Ala Met Tyr Ala Cys Pro Lys Leu Pro Tyr Asn 
        835                 840                 845             


Lys Glu Thr Ser Pro Ser Phe Tyr Phe Ala Ile Ser Thr Gly Ser Leu 
    850                 855                 860                 


Ala Gln Gln Tyr Ala His Pro Asn Ala Thr Leu His Pro His Thr Pro 
865                 870                 875                 880 


His Pro Gln Pro Ser Ala Thr Pro Thr Gly Gln Gln Gln Ser Gln His 
                885                 890                 895     


Gly Gly Ser His Pro Ala Pro Ser Pro Val Gln His His Gln His Gln 
            900                 905                 910         


Ala Ala Gln Ala Leu His Leu Ala Ser Pro Gln Gln Gln Ser Ala Ile 
        915                 920                 925             


Tyr His Ala Gly Leu Ala Pro Thr Pro Pro Ser Met Thr Pro Ala Ser 
    930                 935                 940                 


Asn Thr Gln Ser Pro Gln Asn Ser Phe Pro Ala Ala Gln Gln Thr Val 
945                 950                 955                 960 


Phe Thr Ile His Pro Ser His Val Gln Pro Ala Tyr Thr Asn Pro Pro 
                965                 970                 975     


His Met Ala His Val Pro Gln Cys Ala Ser Glu Ala Leu Ala Arg Cys 
            980                 985                 990         


Gly Leu Glu Met Arg Leu Ser Trp  Ile Tyr Leu Ser Glu  Gly Tyr Leu 
        995                 1000                 1005             


Ala His  Val Gln Ser Gly Met  Val Pro Ser His Pro  Thr Ala His 
    1010                 1015                 1020             


Ala Pro  Met Met Leu Met Thr  Thr Gln Pro Pro Gly  Gly Pro Gln 
    1025                 1030                 1035             


Ala Ala  Leu Ala Gln Ser Ala  Leu Gln Pro Ile Pro  Val Ser Thr 
    1040                 1045                 1050             


Thr Ala  His Phe Pro Tyr Met  Thr His Pro Ser Val  Gln Ala His 
    1055                 1060                 1065             


His Gln  Gln Gln Leu 
    1070             


<210>  25
<211>  3993
<212>  DNA
<213>  Homo sapiens

<400>  25
cccgagaaag caacccagcg cgccgcccgc tcctcacgtg tccctcccgg ccccggggcc       60

acctcacgtt ctgcttccgt ctgacccctc cgacttccga ggtcgaaaca gtaacaaagg      120

actgcctcag tctacgattt cttttgatgg aatctatgca aatatgagga tggttcatat      180

acttacatca gttgttggct ccaaatgtga agtacaagtg aaaaatggag gtatatatga      240

aggagttttt aaaacttaca gtccgaagtg tgatttggta cttgatgccg cacatgagaa      300

aagtacagaa tccagttcgg ggccgaaacg tgaagaaata atggagagta ttttgttcaa      360

atgttcagac tttgttgtgg tacagtttaa agatatggac tccagttatg caaaaagaga      420

tgcttttact gactctgcta tcagtgctaa agtgaatggc gaacacaaag agaaggacct      480

ggagccctgg gatgcaggtg aactcacagc caatgaggaa cttgaggctt tggaaaatga      540

cgtatctaat ggatgggatc ccaatgatat gtttcgatat aatgaagaaa attatggtgt      600

agtgtctacg tatgatagca gtttatcttc gtatacagtg cccttagaaa gagataactc      660

agaagaattt ttaaaacggg aagcaagggc aaaccagtta gcagaagaaa ttgagtcaag      720

tgcccagtac aaagctcgag tggccctgga aaatgatgat aggagtgagg aagaaaaata      780

cacagcagtt cagagaaatt ccagtgaacg tgaggggcac agcataaaca ctagggaaaa      840

taaatatatt cctcctggac aaagaaatag agaagtcata tcctggggaa gtgggagaca      900

gaattcaccg cgtatgggcc agcctggatc gggctccatg ccatcaagat ccacttctca      960

cacttcagat ttcaacccga attctggttc agaccaaaga gtagttaatg gaggtgttcc     1020

ctggccatcg ccttgcccat ctccttcctc tcgcccacct tctcgctacc agtcaggtcc     1080

caactctctt ccacctcggg cagccacccc tacacggccg ccctccaggc ccccctcgcg     1140

gccatccaga cccccgtctc acccctctgc tcatggttct ccagctcctg tctctactat     1200

gcctaaacgc atgtcttcag aagggcctcc aaggatgtcc ccaaaggccc agcgacatcc     1260

tcgaaatcac agagtttctg ctgggagggg ttccatatcc agtggcctag aatttgtatc     1320

ccacaaccca cccagtgaag cagctactcc tccagtagca aggaccagtc cctcgggggg     1380

aacgtggtca tcagtggtca gtggggttcc aagattatcc cctaaaactc atagacccag     1440

gtctcccaga cagaacagta ttggaaatac ccccagtggg ccagttcttg cttctcccca     1500

agctggtatt attccaactg aagctgttgc catgcctatt ccagctgcat ctcctacgcc     1560

tgctagtcct gcatcgaaca gagctgttac cccttctagt gaggctaaag attccaggct     1620

tcaagatcag aggcagaact ctcctgcagg gaataaagaa aatattaaac ccaatgaaac     1680

atcacctagc ttctcaaaag ctgaaaacaa aggtatatca ccagttgttt ctgaacatag     1740

aaaacagatt gatgatttaa agaaatttaa gaatgatttt aggttacagc caagttctac     1800

ttctgaatct atggatcaac tactaaacaa aaatagagag ggagaaaaat caagagattt     1860

gatcaaagac aaaattgaac caagtgctaa ggattctttc attgaaaata gcagcagcaa     1920

ctgtaccagt ggcagcagca agccgaatag ccccagcatt tccccttcaa tacttagtaa     1980

cacggagcac aagaggggac ctgaggtcac ttcccaaggg gttcagactt ccagcccagc     2040

atgtaaacaa gagaaagacg ataaggaaga gaagaaagac gcagctgagc aagttaggaa     2100

atcaacattg aatcccaatg caaaggagtt caacccacgt tccttctctc agccaaagcc     2160

ttctactacc ccaacttcac ctcggcctca agcacaacct agcccatcta tggtgggtca     2220

tcaacagcca actccagttt atactcagcc tgtttgtttt gcaccaaata tgatgtatcc     2280

agtcccagtg agcccaggcg tgcaaccttt atacccaata cctatgacgc ccatgccagt     2340

gaatcaagcc aagacatata gagcagtacc aaatatgccc caacagcggc aagaccagca     2400

tcatcagagt gccatgatgc acccagcgtc agcagcgggc ccaccgattg cagccacccc     2460

accagcttac tccacgcaat atgttgccta cagtcctcag cagttcccaa atcagcccct     2520

tgttcagcat gtgccacatt atcagtctca gcatcctcat gtctatagtc ctgtaataca     2580

gggtaatgct agaatgatgg caccaccaac acacgcccag cctggtttag tatcttcttc     2640

agcaactcag tacggggctc atgagcagac gcatgcgatg tatgcatgtc ccaaattacc     2700

atacaacaag gagacaagcc cttctttcta ctttgccatt tccacgggct cccttgctca     2760

gcagtatgcg caccctaacg ctaccctgca cccacatact ccacaccctc agccttcagc     2820

tacccccact ggacagcagc aaagccaaca tggtggaagt catcctgcac ccagtcctgt     2880

tcagcaccat cagcaccagg ccgcccaggc tctccatctg gccagtccac agcagcagtc     2940

agccatttac cacgcggggc ttgcgccaac tccaccctcc atgacacctg cctccaacac     3000

gcagtcgcca cagaatagtt tcccagcagc acaacagact gtctttacga tccatccttc     3060

tcacgttcag ccggcgtata ccaacccacc ccacatggcc cacgtacctc agtgcgccag     3120

tgaggctctg gcaaggtgtg ggctagagat gcgactcagt tggatctatc tctcagaagg     3180

ctaccttgct catgtacagt caggaatggt tccttctcat ccaactgccc atgcgccaat     3240

gatgctaatg acgacacagc cacccggcgg tccccaggcc gccctcgctc aaagtgcact     3300

acagcccatt ccagtctcga caacagcgca tttcccctat atgacgcacc cttcagtaca     3360

agcccaccac caacagcagt tgtaaggctg ccctggagga accgaaaggc caaattccct     3420

cctcccttct actgcttcta ccaactggaa gcacagaaaa ctagaatttc atttattttg     3480

tttttaaaat atatatgttg atttcttgta acatccaata ggaatgctaa cagttcactt     3540

gcagtggaag atacttggac cgagtagagg catttaggaa cttgggggct attccataat     3600

tccatatgct gtttcagagt cccgcaggta ccccagctct gcttgccgaa actggaagtt     3660

atttattttt taataaccct tgaaagtcat gaacacatca gctagcaaaa gaagtaacaa     3720

gagtgattct tgctgctatt actgctaaaa aaaaaaaaaa aaaaaaatca agacttggaa     3780

cgccctttta ctaaacttga caaagtttca gtaaattctt accgtcaaac tgacggatta     3840

ttatttataa atcaagtttg atgaggtgat cactgtctac agtggttcaa cttttaagtt     3900

aagggaaaaa cttttacttt gtagataata taaaataaaa acttaaaaaa aatttaaaaa     3960

ataaaaaaag ttttaaaaac tgaaaaaaaa aaa                                  3993


<210>  26
<211>  1006
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Arg Met Val His Ile Leu Thr Ser Val Val Cys Asp Leu Val Leu 
1               5                   10                  15      


Asp Ala Ala His Glu Lys Ser Thr Glu Ser Ser Ser Gly Pro Lys Arg 
            20                  25                  30          


Glu Glu Ile Met Glu Ser Ile Leu Phe Lys Cys Ser Asp Phe Val Val 
        35                  40                  45              


Val Gln Phe Lys Asp Met Asp Ser Ser Tyr Ala Lys Arg Asp Ala Phe 
    50                  55                  60                  


Thr Asp Ser Ala Ile Ser Ala Lys Val Asn Gly Glu His Lys Glu Lys 
65                  70                  75                  80  


Asp Leu Glu Pro Trp Asp Ala Gly Glu Leu Thr Ala Asn Glu Glu Leu 
                85                  90                  95      


Glu Ala Leu Glu Asn Asp Val Ser Asn Gly Trp Asp Pro Asn Asp Met 
            100                 105                 110         


Phe Arg Tyr Asn Glu Glu Asn Tyr Gly Val Val Ser Thr Tyr Asp Ser 
        115                 120                 125             


Ser Leu Ser Ser Tyr Thr Val Pro Leu Glu Arg Asp Asn Ser Glu Glu 
    130                 135                 140                 


Phe Leu Lys Arg Glu Ala Arg Ala Asn Gln Leu Ala Glu Glu Ile Glu 
145                 150                 155                 160 


Ser Ser Ala Gln Tyr Lys Ala Arg Val Ala Leu Glu Asn Asp Asp Arg 
                165                 170                 175     


Ser Glu Glu Glu Lys Tyr Thr Ala Val Gln Arg Asn Ser Ser Glu Arg 
            180                 185                 190         


Glu Gly His Ser Ile Asn Thr Arg Glu Asn Lys Tyr Ile Pro Pro Gly 
        195                 200                 205             


Gln Arg Asn Arg Glu Val Ile Ser Trp Gly Ser Gly Arg Gln Asn Ser 
    210                 215                 220                 


Pro Arg Met Gly Gln Pro Gly Ser Gly Ser Met Pro Ser Arg Ser Thr 
225                 230                 235                 240 


Ser His Thr Ser Asp Phe Asn Pro Asn Ser Gly Ser Asp Gln Arg Val 
                245                 250                 255     


Val Asn Gly Gly Val Pro Trp Pro Ser Pro Cys Pro Ser Pro Ser Ser 
            260                 265                 270         


Arg Pro Pro Ser Arg Tyr Gln Ser Gly Pro Asn Ser Leu Pro Pro Arg 
        275                 280                 285             


Ala Ala Thr Pro Thr Arg Pro Pro Ser Arg Pro Pro Ser Arg Pro Ser 
    290                 295                 300                 


Arg Pro Pro Ser His Pro Ser Ala His Gly Ser Pro Ala Pro Val Ser 
305                 310                 315                 320 


Thr Met Pro Lys Arg Met Ser Ser Glu Gly Pro Pro Arg Met Ser Pro 
                325                 330                 335     


Lys Ala Gln Arg His Pro Arg Asn His Arg Val Ser Ala Gly Arg Gly 
            340                 345                 350         


Ser Ile Ser Ser Gly Leu Glu Phe Val Ser His Asn Pro Pro Ser Glu 
        355                 360                 365             


Ala Ala Thr Pro Pro Val Ala Arg Thr Ser Pro Ser Gly Gly Thr Trp 
    370                 375                 380                 


Ser Ser Val Val Ser Gly Val Pro Arg Leu Ser Pro Lys Thr His Arg 
385                 390                 395                 400 


Pro Arg Ser Pro Arg Gln Asn Ser Ile Gly Asn Thr Pro Ser Gly Pro 
                405                 410                 415     


Val Leu Ala Ser Pro Gln Ala Gly Ile Ile Pro Thr Glu Ala Val Ala 
            420                 425                 430         


Met Pro Ile Pro Ala Ala Ser Pro Thr Pro Ala Ser Pro Ala Ser Asn 
        435                 440                 445             


Arg Ala Val Thr Pro Ser Ser Glu Ala Lys Asp Ser Arg Leu Gln Asp 
    450                 455                 460                 


Gln Arg Gln Asn Ser Pro Ala Gly Asn Lys Glu Asn Ile Lys Pro Asn 
465                 470                 475                 480 


Glu Thr Ser Pro Ser Phe Ser Lys Ala Glu Asn Lys Gly Ile Ser Pro 
                485                 490                 495     


Val Val Ser Glu His Arg Lys Gln Ile Asp Asp Leu Lys Lys Phe Lys 
            500                 505                 510         


Asn Asp Phe Arg Leu Gln Pro Ser Ser Thr Ser Glu Ser Met Asp Gln 
        515                 520                 525             


Leu Leu Asn Lys Asn Arg Glu Gly Glu Lys Ser Arg Asp Leu Ile Lys 
    530                 535                 540                 


Asp Lys Ile Glu Pro Ser Ala Lys Asp Ser Phe Ile Glu Asn Ser Ser 
545                 550                 555                 560 


Ser Asn Cys Thr Ser Gly Ser Ser Lys Pro Asn Ser Pro Ser Ile Ser 
                565                 570                 575     


Pro Ser Ile Leu Ser Asn Thr Glu His Lys Arg Gly Pro Glu Val Thr 
            580                 585                 590         


Ser Gln Gly Val Gln Thr Ser Ser Pro Ala Cys Lys Gln Glu Lys Asp 
        595                 600                 605             


Asp Lys Glu Glu Lys Lys Asp Ala Ala Glu Gln Val Arg Lys Ser Thr 
    610                 615                 620                 


Leu Asn Pro Asn Ala Lys Glu Phe Asn Pro Arg Ser Phe Ser Gln Pro 
625                 630                 635                 640 


Lys Pro Ser Thr Thr Pro Thr Ser Pro Arg Pro Gln Ala Gln Pro Ser 
                645                 650                 655     


Pro Ser Met Val Gly His Gln Gln Pro Thr Pro Val Tyr Thr Gln Pro 
            660                 665                 670         


Val Cys Phe Ala Pro Asn Met Met Tyr Pro Val Pro Val Ser Pro Gly 
        675                 680                 685             


Val Gln Pro Leu Tyr Pro Ile Pro Met Thr Pro Met Pro Val Asn Gln 
    690                 695                 700                 


Ala Lys Thr Tyr Arg Ala Val Pro Asn Met Pro Gln Gln Arg Gln Asp 
705                 710                 715                 720 


Gln His His Gln Ser Ala Met Met His Pro Ala Ser Ala Ala Gly Pro 
                725                 730                 735     


Pro Ile Ala Ala Thr Pro Pro Ala Tyr Ser Thr Gln Tyr Val Ala Tyr 
            740                 745                 750         


Ser Pro Gln Gln Phe Pro Asn Gln Pro Leu Val Gln His Val Pro His 
        755                 760                 765             


Tyr Gln Ser Gln His Pro His Val Tyr Ser Pro Val Ile Gln Gly Asn 
    770                 775                 780                 


Ala Arg Met Met Ala Pro Pro Thr His Ala Gln Pro Gly Leu Val Ser 
785                 790                 795                 800 


Ser Ser Ala Thr Gln Tyr Gly Ala His Glu Gln Thr His Ala Met Tyr 
                805                 810                 815     


Val Ser Thr Gly Ser Leu Ala Gln Gln Tyr Ala His Pro Asn Ala Thr 
            820                 825                 830         


Leu His Pro His Thr Pro His Pro Gln Pro Ser Ala Thr Pro Thr Gly 
        835                 840                 845             


Gln Gln Gln Ser Gln His Gly Gly Ser His Pro Ala Pro Ser Pro Val 
    850                 855                 860                 


Gln His His Gln His Gln Ala Ala Gln Ala Leu His Leu Ala Ser Pro 
865                 870                 875                 880 


Gln Gln Gln Ser Ala Ile Tyr His Ala Gly Leu Ala Pro Thr Pro Pro 
                885                 890                 895     


Ser Met Thr Pro Ala Ser Asn Thr Gln Ser Pro Gln Asn Ser Phe Pro 
            900                 905                 910         


Ala Ala Gln Gln Thr Val Phe Thr Ile His Pro Ser His Val Gln Pro 
        915                 920                 925             


Ala Tyr Thr Asn Pro Pro His Met Ala His Val Pro Gln Ala His Val 
    930                 935                 940                 


Gln Ser Gly Met Val Pro Ser His Pro Thr Ala His Ala Pro Met Met 
945                 950                 955                 960 


Leu Met Thr Thr Gln Pro Pro Gly Gly Pro Gln Ala Ala Leu Ala Gln 
                965                 970                 975     


Ser Ala Leu Gln Pro Ile Pro Val Ser Thr Thr Ala His Phe Pro Tyr 
            980                 985                 990         


Met Thr His Pro Ser Val Gln Ala  His His Gln Gln Gln  Leu 
        995                 1000                 1005     


<210>  27
<211>  3755
<212>  DNA
<213>  Homo sapiens

<400>  27
cccgagaaag caacccagcg cgccgcccgc tcctcacgtg tccctcccgg ccccggggcc       60

acctcacgtt ctgcttccgt ctgacccctc cgacttccga tttcttttga tggaatctat      120

gcaaatatga ggatggttca tatacttaca tcagttgttt gtgatttggt acttgatgcc      180

gcacatgaga aaagtacaga atccagttcg gggccgaaac gtgaagaaat aatggagagt      240

attttgttca aatgttcaga ctttgttgtg gtacagttta aagatatgga ctccagttat      300

gcaaaaagag atgcttttac tgactctgct atcagtgcta aagtgaatgg cgaacacaaa      360

gagaaggacc tggagccctg ggatgcaggt gaactcacag ccaatgagga acttgaggct      420

ttggaaaatg acgtatctaa tggatgggat cccaatgata tgtttcgata taatgaagaa      480

aattatggtg tagtgtctac gtatgatagc agtttatctt cgtatacagt gcccttagaa      540

agagataact cagaagaatt tttaaaacgg gaagcaaggg caaaccagtt agcagaagaa      600

attgagtcaa gtgcccagta caaagctcga gtggccctgg aaaatgatga taggagtgag      660

gaagaaaaat acacagcagt tcagagaaat tccagtgaac gtgaggggca cagcataaac      720

actagggaaa ataaatatat tcctcctgga caaagaaata gagaagtcat atcctgggga      780

agtgggagac agaattcacc gcgtatgggc cagcctggat cgggctccat gccatcaaga      840

tccacttctc acacttcaga tttcaacccg aattctggtt cagaccaaag agtagttaat      900

ggaggtgttc cctggccatc gccttgccca tctccttcct ctcgcccacc ttctcgctac      960

cagtcaggtc ccaactctct tccacctcgg gcagccaccc ctacacggcc gccctccagg     1020

cccccctcgc ggccatccag acccccgtct cacccctctg ctcatggttc tccagctcct     1080

gtctctacta tgcctaaacg catgtcttca gaagggcctc caaggatgtc cccaaaggcc     1140

cagcgacatc ctcgaaatca cagagtttct gctgggaggg gttccatatc cagtggccta     1200

gaatttgtat cccacaaccc acccagtgaa gcagctactc ctccagtagc aaggaccagt     1260

ccctcggggg gaacgtggtc atcagtggtc agtggggttc caagattatc ccctaaaact     1320

catagaccca ggtctcccag acagaacagt attggaaata cccccagtgg gccagttctt     1380

gcttctcccc aagctggtat tattccaact gaagctgttg ccatgcctat tccagctgca     1440

tctcctacgc ctgctagtcc tgcatcgaac agagctgtta ccccttctag tgaggctaaa     1500

gattccaggc ttcaagatca gaggcagaac tctcctgcag ggaataaaga aaatattaaa     1560

cccaatgaaa catcacctag cttctcaaaa gctgaaaaca aaggtatatc accagttgtt     1620

tctgaacata gaaaacagat tgatgattta aagaaattta agaatgattt taggttacag     1680

ccaagttcta cttctgaatc tatggatcaa ctactaaaca aaaatagaga gggagaaaaa     1740

tcaagagatt tgatcaaaga caaaattgaa ccaagtgcta aggattcttt cattgaaaat     1800

agcagcagca actgtaccag tggcagcagc aagccgaata gccccagcat ttccccttca     1860

atacttagta acacggagca caagagggga cctgaggtca cttcccaagg ggttcagact     1920

tccagcccag catgtaaaca agagaaagac gataaggaag agaagaaaga cgcagctgag     1980

caagttagga aatcaacatt gaatcccaat gcaaaggagt tcaacccacg ttccttctct     2040

cagccaaagc cttctactac cccaacttca cctcggcctc aagcacaacc tagcccatct     2100

atggtgggtc atcaacagcc aactccagtt tatactcagc ctgtttgttt tgcaccaaat     2160

atgatgtatc cagtcccagt gagcccaggc gtgcaacctt tatacccaat acctatgacg     2220

cccatgccag tgaatcaagc caagacatat agagcagtac caaatatgcc ccaacagcgg     2280

caagaccagc atcatcagag tgccatgatg cacccagcgt cagcagcggg cccaccgatt     2340

gcagccaccc caccagctta ctccacgcaa tatgttgcct acagtcctca gcagttccca     2400

aatcagcccc ttgttcagca tgtgccacat tatcagtctc agcatcctca tgtctatagt     2460

cctgtaatac agggtaatgc tagaatgatg gcaccaccaa cacacgccca gcctggttta     2520

gtatcttctt cagcaactca gtacggggct catgagcaga cgcatgcgat gtatgtttcc     2580

acgggctccc ttgctcagca gtatgcgcac cctaacgcta ccctgcaccc acatactcca     2640

caccctcagc cttcagctac ccccactgga cagcagcaaa gccaacatgg tggaagtcat     2700

cctgcaccca gtcctgttca gcaccatcag caccaggccg cccaggctct ccatctggcc     2760

agtccacagc agcagtcagc catttaccac gcggggcttg cgccaactcc accctccatg     2820

acacctgcct ccaacacgca gtcgccacag aatagtttcc cagcagcaca acagactgtc     2880

tttacgatcc atccttctca cgttcagccg gcgtatacca acccacccca catggcccac     2940

gtacctcagg ctcatgtaca gtcaggaatg gttccttctc atccaactgc ccatgcgcca     3000

atgatgctaa tgacgacaca gccacccggc ggtccccagg ccgccctcgc tcaaagtgca     3060

ctacagccca ttccagtctc gacaacagcg catttcccct atatgacgca cccttcagta     3120

caagcccacc accaacagca gttgtaaggc tgccctggag gaaccgaaag gccaaattcc     3180

ctcctccctt ctactgcttc taccaactgg aagcacagaa aactagaatt tcatttattt     3240

tgtttttaaa atatatatgt tgatttcttg taacatccaa taggaatgct aacagttcac     3300

ttgcagtgga agatacttgg accgagtaga ggcatttagg aacttggggg ctattccata     3360

attccatatg ctgtttcaga gtcccgcagg taccccagct ctgcttgccg aaactggaag     3420

ttatttattt tttaataacc cttgaaagtc atgaacacat cagctagcaa aagaagtaac     3480

aagagtgatt cttgctgcta ttactgctaa aaaaaaaaaa aaaaaaaaat caagacttgg     3540

aacgcccttt tactaaactt gacaaagttt cagtaaattc ttaccgtcaa actgacggat     3600

tattatttat aaatcaagtt tgatgaggtg atcactgtct acagtggttc aacttttaag     3660

ttaagggaaa aacttttact ttgtagataa tataaaataa aaacttaaaa aaaatttaaa     3720

aaataaaaaa agttttaaaa actgaaaaaa aaaaa                                3755


<210>  28
<211>  67
<212>  DNA
<213>  Homo sapiens

<400>  28
cagcagccgc cgcccgcggc tgccaatgtc cgcaagcccg gcggcagcgg ccttctagcg       60

tcgcccg                                                                 67


<210>  29
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Edited gene sequence

<400>  29
cagcagccgc cgcccgcggc tgccaatgtc cgcaagcctt ctagcgtcgc ccg              53


<210>  30
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Edited gene sequence

<400>  30
cagcagccgc cgcccgcggc tgccaatgtc ccggcggcag cggccttcta ggcgtcgccc       60

g                                                                       61


<210>  31
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Edited gene sequence

<400>  31
cagcagccgc cgcccgcctt ctagcgtcgc ccg                                    33


<210>  32
<211>  88
<212>  DNA
<213>  Homo sapiens

<400>  32
gcgcccgccc tccgatgcgc tcagcggccg cagctccgcg gctgccaatg tccgcaagcc       60

cggcggcagc ggccttctag cgtcgccc                                          88


<210>  33
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Edited gene sequence

<400>  33
gcgcccgccc tccgatgcgc tccggcggca gcggccttct agcgtcgccc                  50


<210>  34
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Edited gene sequence

<400>  34
gcgcccgccc tccgatgcgc tcggcggcag cggccttcta gcgtcgccc                   49


<210>  35
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Edited gene sequence

<400>  35
gcgcccggcg gcagcggcct tctagcgtcg ccc                                    33


<210>  36
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Edited gene sequence

<400>  36
gcgcccgccc tccgatgcgc tcggcggcag cggccttcta gcgtcgccc                   49


<210>  37
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Edited gene sequence

<400>  37
gcgcccgccc tccgatgcgc tggcggcagc ggccttctag cgtcgccc                    48


<210>  38
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Edited gene sequence

<400>  38
cgcgcccgcc ctccgatgcg ctccggcggc agcggccttc tagcgtcgcc cg               52


<210>  39
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Edited gene sequence

<400>  39
cgcgcccgcc ctccgatgcg ctcggcggca gcggccttct agcgtcgccc g                51


<210>  40
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Edited gene sequence

<400>  40
cgcgcccgcc ctccgatgcg ctggcggcag cggccttcta gcgtcgcccg                  50


<210>  41
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  41
gcttctctcc tgtcctccac accag                                             25


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  42
ccatcgccgc tacccgagaa c                                                 21


<210>  43
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  43
tcgtcctcgg tctcctcgtc c                                                 21


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  44
actggcatgg gcgtcatagg                                                   20


<210>  45
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  45
gcccacgtac ctcagtg                                                      17


<210>  46
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  46
aggtagcctt ctgagagata ga                                                22


<210>  47
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic probe

<400>  47
caaggtgtgg gctagagatg cgac                                              24


<210>  48
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  48
agcctggttt agtatcttct tcag                                              24


<210>  49
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  49
gcgttagggt gcgcata                                                      17


<210>  50
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic probe

<400>  50
atgcgatgta tgtttccacg ggct                                              24


